Dorothy Lerit Ph.D.
Overview
Our research interests include understanding how centrosome activity is regulated in space and time, how individual centrosomes are differentially regulated within single cells, and how centrosome regulation contributes to cell and animal viability.
Academic Appointment
- Associate Professor, Department of Cell Biology, Emory University School of Medicine
Education
Degrees
- Ph.D., Molecular Biology from Princeton University
- B.S., Biology from University of Massachusetts
Research
Focus
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Centrosomes in development and disease
Defects in centrosome regulation are associated with developmental disorders and disease, such as microcephaly, sterility, ciliopathy, and cancer. We take an interdisciplinary approach to investigate mechanisms of centrosome regulation within pluripotent cells (e.g., stem cells and embryos) to model the etiology of centrosome-associated pathophysiologies.
Publications
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The PCM scaffold enables RNA localization to centrosomes.
Mol Biol Cell Volume: 36 Page(s): ar75
06/01/2025 Authors: Fang J; Tian W; Quintanilla MA; Beach JR; Lerit DA -
Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model.
G3 (Bethesda) Volume: 15
05/08/2025 Authors: Adebambo TH; Medina-Flores F; Zhang S; Lerit DA -
Visualization of the Cytoskeleton in Fixed Drosophila Embryos.
Curr Protoc Volume: 5 Page(s): e70145
05/01/2025 Authors: Fang J; Brockett JS; Tian W; Hua Y; Gavis ER; Lerit DA -
Centrocortin potentiates co-translational localization of its mRNA to the centrosome via dynein.
bioRxiv
08/09/2024 Authors: Zein-Sabatto H; Brockett JS; Jin L; Husbands CA; Lee J; Fang J; Buehler J; Bullock SL; Lerit DA -
Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model.
08/07/2024 Authors: Adebambo TH; Flores MFM; Zhang SL; Lerit DA -
A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila.
Genetics Volume: 226
04/03/2024 Authors: Brockett JS; Manalo T; Zein-Sabatto H; Lee J; Fang J; Chu P; Feng H; Patil D; Davidson P; Ogan K -
The PCM scaffold enables RNA localization to centrosomes.
bioRxiv
01/14/2024 Authors: Fang J; Tian W; Quintanilla MA; Beach JR; Lerit DA -
Colorimetric Synchronization of Drosophila Larvae.
Curr Protoc Volume: 3 Page(s): e924
10/01/2023 Authors: Hailstock T; Terry D; Wardwell-Ozgo J; Robinson BV; Moberg KH; Lerit DA -
Analysis of factors required for Centrocortin mRNA localization to centrosomes in Drosophila embryos
Volume: 34 Page(s): 505 - 505
02/01/2023 Authors: Husbands C; Zein-Sabatto H; Lerit DA -
Identifying mechanisms underlying Orb2-dependent regulation of neural stem cell centrosome asymmetry
Volume: 34 Page(s): 645 - 646
02/01/2023 Authors: Buehler J; Lerit DA