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Profile

David Guidot MD

  • Department of Medicine
    Professor
  • (404) 712-2970
  • dguidot@emory.edu
  • Emory University
    Medicine/Division of Pulmonary, Allergy, Critical Care & Sleep Medicine
    615 Michael Street, Suite 205
Head shot of David Guidot

Overview

Dr. Guidot completed undergraduate and medical school education at the University of Michigan, obtaining his MD in 1984. He trained in Internal Medicine at the University of Minnesota from 1984-1987 and then served an additional year as Chief Medical Resident. After his chief residency, he moved to the University of Colorado for clinical and research fellowship training in Pulmonary & Critical Care Medicine from 1988-1992 where he worked in the laboratories of John Repine and Joe McCord. After three years as Assistant Professor at Colorado, he was recruited to Emory University in 1995 by Dr. Roland Ingram and started an independent research laboratory at the Atlanta VA Medical Center. In 1999, he was promoted to Associate Professor of Medicine with tenure, and in 2006 was promoted to the rank of Professor of Medicine with tenure. He has served in numerous leadership positions since joining the Emory faculty, including Pulmonary Section Chief at the VA, Director of the Pulmonary and Critical Care Medicine Fellowship Training Program, and Associate Division Director for Research. In 2009, he became Division Director and in 2010 was appointed as the Jeffrey R. Pine Chaired Professor of Medicine through the generous endowment of the Amos family.

Dr. Guidot has focused his research on the mechanisms by which chronic insults such as alcohol abuse and HIV infection cause oxidative stress and render individuals susceptible to pneumonia and acute lung injury. He has been continuously funded by extramural sources including the NIH for three decades and directs a large multidisciplinary research program that spans experimental laboratory studies to clinical trials. He is a dedicated mentor who has trained more than twenty-five post-doctoral MD and PhD fellows, many of whom remain in academic careers, and has directed an NIH T32 training program since 2002. He has also mentored multiple junior faculty investigators on their NIH- or VA-funded career development awards. In addition to his research and administrative activities, he continues to see patients and supervise students, residents and fellows at Grady Memorial Hospital.

Academic Appointment

  • Professor of Medicine with tenure, Division of Pulmonary, Allergy & Critical Care Medicine, Emory University

Education

Degrees

  • BS from University of Michigan
  • MD from University of Michigan

Research

Focus

  • My research focus is identifying mechanisms by which oxidative stress injures the lung. Currently, a significant aspect of this work involves the study of how chronic alcohol ingestion and/or HIV-1 perturbs the homeostasis of the critical antioxidant, glutathione, and how glutathione depletion leads to an array of cellular defects that render the lung susceptible to acute edematous injury and infection. More recently, we have focused on the roles of zinc depletion and down-regulation of the transcription factor Nrf2

Publications

  • Ethanol-exposed lung fibroblasts cause airway epithelial barrier dysfunction.
    Alcohol Clin Exp Res (Hoboken) Volume: 47 Page(s): 1839 - 1849
    10/01/2023 Authors: Sueblinvong V; Fan X; Hart C; Molina S; Koval M; Guidot DM
  • MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
    Shock Volume: 59 Page(s): 612 - 620
    04/01/2023 Authors: Chihade DB; Smith P; Swift DA; Otani S; Zhang W; Chen C-W; Jeffers LA; Liang Z; Shimazui T; Burd EM
  • Alcohol impairs recognition and uptake of Mycobacterium tuberculosis by suppressing toll-like receptor 2 expression.
    Alcohol Clin Exp Res Volume: 46 Page(s): 2214 - 2224
    12/01/2022 Authors: Wigger GW; Khani D; Ahmed M; Sayegh L; Auld SC; Fan X; Guidot DM; Staitieh BS
  • Chronic Alcohol Exposure Impairs Alveolar Macrophage Effector Function and Heme Oxygenase-1 Expression in Response to Mycobacterium Tuberculosis
    Volume: 205
    05/01/2022 Authors: Wigger GW; Khani D; Auld S; Fan X; Guidot DM; Staitieh BS
  • ARDS - Paradigms Lost and Found.
    Am J Med Sci Volume: 362 Page(s): 535 - 536
    12/01/2021 Authors: Guidot DM
  • Alcohol impairs alveolar macrophages responses to Mycobacterium tuberculosis
    Volume: 203
    05/01/2021 Authors: Sayegh L; Ahmed M; Fan X; Auld S; Guidot DM; Staitieh BS
  • ALCOHOL IMPAIRS ALVEOLAR MACROPHAGES RESPONSES TO MYCOBACTERIUM TUBERCULOSIS
    Volume: 69 Page(s): 458 - 458
    02/01/2021 Authors: Sayegh L; Ahmed M; Fan X; Auld SC; Guidot D; Staitieh BS
  • HIV Impairs Alveolar Macrophage Function via MicroRNA-144-Induced Suppression of Nrf2.
    Am J Med Sci Volume: 361 Page(s): 90 - 97
    01/01/2021 Authors: Fan X; Murray SC; Staitieh BS; Spearman P; Guidot DM
  • HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
    Sci Rep Volume: 10 Page(s): 11696
    07/16/2020 Authors: Almodovar S; Wade BE; Porter KM; Smith JM; Lopez-Astacio RA; Bijli K; Kang B-Y; Cribbs SK; Guidot DM; Molehin D
  • CHRONIC ALCOHOL INGESTION INDUCES CIRCADIAN DYSREGULATION OF PROFIBROTIC GENES IN THE MURINE LUNG
    Volume: 44 Page(s): 48 - 48
    06/01/2020 Authors: Stephens D; Fan X; Staitieh B; Guidot DM; Sueblinvong V
  • ALCOHOL INDUCES CIRCADIAN DYSREGULATION OF PROFIBROTIC GENES IN THE MURINE LUNG
    Volume: 68 Page(s): 667 - 667
    02/01/2020 Authors: Stephens D; Fan X; Staitieh BS; Guidot D; Sueblinvong V
  • Type-2 Cannabinoid Receptors Maintain Epithelial Barrier in Aspirin-Exacerbated Respiratory Disease
    Volume: 145 Page(s): AB148 - AB148
    02/01/2020 Authors: Levy J; Watkins L; Mashburn S; Roland L; Battle M; Molina S; Wise S; DelGaudio J; Moore B; Guidot D
  • RAT ALVEOLAR MACROPHAGE MMP-9 IS INCREASED BY HIV AND DECREASED BY ACTIVATION OF ANTIOXIDANT DEFENSES
    Volume: 68 Page(s): 668 - 668
    02/01/2020 Authors: Cook C; Murray SC; Fan X; Roth AT; Guidot D; Staitieh BS
  • CHRONIC ALCOHOL INGESTION IMPAIRS MITOCHONDRIAL BIOENERGETICS IN RAT ALVEOLAR MACROPHAGES
    Volume: 68 Page(s): 667 - 668
    02/01/2020 Authors: Khani D; Ahmed M; Fan X; Yeligar S; Guidot D; Staitieh BS
  • Rat Alveolar Macrophage MMP-9 Is Increased by HIV and Decreased by Activation of Antioxidant Defenses
    Volume: 201
    01/01/2020 Authors: Murray SC; Cook CP; Fan X; Roth A; Guidot DM; Staitieh BS
  • HIV-Induced MiR144 Impairs Alveolar Macrophage Function by Targeting Nrf2 in HIV-1 Transgenic Rats
    Volume: 201
    01/01/2020 Authors: Fan X; Murray SC; Staitieh BS; Spearman P; Guidot DM
  • Lung Transplantation and Donor-Specific Antigens: Clinical and Serologic Factors Associated with Survival and Allograft Dysfunction
    Volume: 201
    01/01/2020 Authors: Guidot DM; Ghosh S; Madala N; Varghese J; Banga A; Bollineni S; Joerns JO; Lawrence A; Mohanka M; Zhu C
  • Correction: Chronic Alcohol Ingestion Increases Mortality and Organ Injury in a Murine Model of Septic Peritonitis.
    PLoS One Volume: 15 Page(s): e0239568
    01/01/2020 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
  • Human Immunodeficiency Virus (HIV) Protease Inhibitors Associated with Pulmonary Function Abnormalities Among Atlanta Women's Interagency HIV Study (WIHS) Participants
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 201
    01/01/2020 Authors: Terry C; Mehta C; Sheth A; Ofotokun I; Staitieh BS; Guidot DM; Cribbs SK
  • SSCI Presidential Symposium Presented at the 2019 Southern Regional Meeting: HIV-Mediated Tissue Injury in the Era of Anti-Retroviral Therapy.
    Am J Med Sci Volume: 358 Page(s): 375
    12/01/2019 Authors: Guidot DM
  • POEMS SYNDROME PRESENTING AS HYPOXIC RESPIRATORY FAILURE WITH PLEURAL EFFUSIONS
    Volume: 156 Page(s): 878A - 878A
    10/01/2019 Authors: Guidot D
  • Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling.
    Cell Death Dis Volume: 10 Page(s): 580
    08/02/2019 Authors: Yuan Z; Petree JR; Lee FE-H; Fan X; Salaita K; Guidot DM; Sadikot RT
  • MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats.
    Am J Physiol Cell Physiol Volume: 317 Page(s): C390 - C397
    08/01/2019 Authors: Kukoyi AT; Fan X; Staitieh BS; Hybertson BM; Gao B; McCord JM; Guidot DM
  • Alcohol-Induced Interleukin-17 Expression Causes Murine Lung Fibroblast-to-Myofibroblast Transdifferentiation via Thy-1 Down-Regulation.
    Alcohol Clin Exp Res Volume: 43 Page(s): 1427 - 1438
    07/01/2019 Authors: Neveu WA; Staitieh BS; Mills ST; Guidot DM; Sueblinvong V
  • HIV-1 Protein gp120 Induces Mouse Lung Fibroblast-to-Myofibroblast Transdifferentiation via CXCR4 Activation.
    Am J Med Sci Volume: 357 Page(s): 483 - 491
    06/01/2019 Authors: Marts LT; Guidot DM; Sueblinvong V
  • Pseudomonas aeruginosa accentuates inflammatory responses under HIV infection through TREM-1 activation
    Volume: 33
    04/01/2019 Authors: Yuan Z; Fan X; Maurice NM; Bedi B; Guidot DM; Sadikot RT
  • MATRIX METALLOPROTEINASE-9 IS ENHANCED BY INTERFERON GAMMA AND HIV-1 TRANSGENE EXPRESSION IN RAT ALVEOLAR MACROPHAGES
    Volume: 67 Page(s): 554 - 555
    02/01/2019 Authors: Roth AT; Ahmed M; Auld SC; Fan X; Guidot D; Staitieh BS
  • MICRORNA-144 MEDIATES ALVEOLAR MACROPHAGE DYSFUNCTION IN HIV-1 TRANSGENIC RATS
    Volume: 67 Page(s): 552 - 553
    02/01/2019 Authors: Murray SC; Fan X; Guidot D
  • HIV-1 TRANSGENE EXPRESSION INDUCES PROSTANOID SIGNALING DYSFUNCTION IN RAT ALVEOLAR MACROPHAGES
    Volume: 67 Page(s): 543 - 544
    02/31/2019 Authors: Cook C; Cribbs SK; Ahmed M; Fan X; Guidot D; Staitieh BS
  • HIV-RELATED VIRAL PROTEIN EXPOSURE IMPAIRS ALVEOLAR MACROPHAGE MITOCHRONDRIAL FUNCTION
    Volume: 67 Page(s): 615 - 616
    02/01/2019 Authors: Smirnova N; Yeligar S; Ahmed M; Fan X; Guidot D; Staitieh BS
  • ANTIOXIDANTS IMPROVE LUNG IMMUNITY AS WELL AS T-CELL PROLIFERATION AND ACTIVATION PROFILES IN HIV-1 IMMUNE NON-RESPONDERS
    Volume: 67 Page(s): 612 - 612
    02/01/2019 Authors: Ahmed M; Cribbs SK; Staitieh BS; Brown L; Paiardini M; King C; Marconi V; Guidot D
  • HIV-1 Transgene Expression Alters Prostanoid Signaling in Rat Alveolar Macrophages
    Volume: 199
    01/01/2019 Authors: Cook C; Cribbs SK; Ahmed M; Fan X; Guidot DM; Staitieh BS
  • HIV-Related Viral Proteins Impair Mitochondrial Function in Rat Alveolar Macrophages
    Volume: 199
    01/01/2019 Authors: Smirnova N; Yeligar SM; Ahmed M; Fan X; Guidot DM; Staitieh BS
  • HIV-Related Viral Proteins and Interferon Gamma Both Enhance Matrix Metalloproteinase-9 Expression in Rat Alveolar Macrophages
    Volume: 199
    01/01/2019 Authors: Kukoyi A; Roth AT; Ahmed M; Auld SC; Fan X; Guidot DM; Staitieh BS
  • MicroRNA-144 Mediates Alveolar Macrophage Dysfunction in HIV-1 Transgenic Rats
    Volume: 199
    01/01/2019 Authors: Murray S; Fan X; Staitieh BS; Guidot DM
  • Ex Vivo Vitamin D Stimulation of Alveolar Macrophage Phagocytosis Index in People Living with HIV, Stratified by Smoking Status
    Volume: 199
    01/01/2019 Authors: Han J; Cribbs SK; Guidot DM; Tangpricha V; Martin GS; Brown LS
  • Do UC What I See? The Role of Eosinophils in Ulcerative Colitis Associated Airway Disease: A Discussion of Pathophysiology and Treatment Options
    Volume: 199
    01/01/2019 Authors: Greer MK; Kaltz E; Guidot DM
  • Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study.
    Int Forum Allergy Rhinol Volume: 8 Page(s): 1184 - 1189
    10/01/2018 Authors: Corrado A; Battle M; Wise SK; Lee FE-H; Guidot DM; DelGaudio JM; Molina SA; Levy JM
  • Chronic Alcohol Ingestion Impairs Rat Alveolar Macrophage Phagocytosis via Disruption of RAGE Signaling.
    Am J Med Sci Volume: 355 Page(s): 497 - 505
    05/01/2018 Authors: Staitieh BS; Egea EE; Fan X; Amah A; Guidot DM
  • miR144 Regulates Nrf2 Expression In Primary Alveolar Epithelial Cells Derived From HIV-1 Transgenic Rats
    Volume: 32
    04/01/2018 Authors: Fan X; Staitieh BB; Raynor R; Kukoyi A; Guidot DM
  • HIV-1 ENVELOPE PROTEIN GP120 AUGMENTS MARKERS OF MYOFIBROBLASTIC DIFFERENTIATION IN MOUSE LUNG FIBROBLASTS
    Volume: 66 Page(s): 596 - 597
    02/01/2018 Authors: Marts L; Guidot D; Sueblinvong V
  • TH17 CYTOKINE PRODUCTION INDUCED BY ALCOHOL EXPOSURE CONTRIBUTES TO MYOFIBROBLAST DEVELOPMENT
    Volume: 66 Page(s): 595 - 595
    02/01/2018 Authors: Neveu WA; Marts L; Guidot D; Sueblinvong V
  • HIV MODULATES PROSTANOID RECEPTOR EXPRESSION IN ALVEOLAR MACROPHAGES
    Volume: 66 Page(s): 539 - 540
    02/01/2018 Authors: Knott EP; Cribbs SK; Kukoyi A; Fan X; Guidot D; Staitieh BS
  • HIV TRANSGENE EXPRESSION INCREASES MATRIX METALLOPROTEINASE 9 IN RAT ALVEOLAR MACROPHAGES
    Volume: 66 Page(s): 594 - 594
    02/01/2018 Authors: Roth AT; Fan X; Kukoyi A; Auld SC; Guidot D; Staitieh BS
  • HIV-1 Envelope Protein gp120 Induces Fibroblast-to-Myofibroblast Transdifferentiation in Mouse Lung Fibroblasts
    Volume: 197
    01/01/2018 Authors: Marts L; Guidot DM; Sueblinvong V
  • HIV Impairs Prostanoid Receptor Expression in Alveolar Macrophages
    Volume: 197
    01/01/2018 Authors: Knott E; Cribbs SK; Kukoyi A; Fan X; Guidot DM; Staitieh BS
  • Exosomal Micro RNAs Shuttling from HIV Viral Protein-Treated Macrophages Disrupt Tight Junction Barrier Integrity and Mitochondrial Biogenesis of Alveolar Epithelial Cells
    Volume: 197
    01/01/2018 Authors: Yuan Z; Fan X; Maurice NM; Bedi B; Guidot DM; Sadikot RT
  • HIV Transgene Expression Increases Matrix Metalloproteinase-9 in Rat Alveolar Macrophages
    Volume: 197
    01/01/2018 Authors: Kukoyi A; Roth AT; Ahmed M; Fan X; Auld SC; Guidot DM; Staitieh BS
  • Dysregulation of Alveolar Macrophage PPAR, NADPH Oxidases, and TGF1 in Otherwise Healthy HIV-Infected Individuals.
    AIDS Res Hum Retroviruses Volume: 33 Page(s): 1018 - 1026
    10/01/2017 Authors: Yeligar SM; Ward JM; Harris FL; Brown LAS; Guidot DM; Cribbs SK
  • HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages.
    J Leukoc Biol Volume: 102 Page(s): 517 - 525
    08/01/2017 Authors: Staitieh BS; Ding L; Neveu WA; Spearman P; Guidot DM; Fan X
  • 2017 Founders' Medal Acceptance.
    Am J Med Sci Volume: 354 Page(s): 78 - 80
    07/01/2017 Authors: Guidot DM
  • Pulmonary Innate Immune Dysfunction in Human Immunodeficiency Virus.
    Am J Respir Cell Mol Biol Volume: 56 Page(s): 563 - 567
    05/01/2017 Authors: Staitieh BS; Egea EE; Guidot DM
  • HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1.
    Sci Rep Volume: 7 Page(s): 42028
    02/09/2017 Authors: Yuan Z; Fan X; Staitieh B; Bedi C; Spearman P; Guidot DM; Sadikot RT
  • MITOCHONDRIAL FUNCTION IN ALVEOLAR MACROPHAGES IS IMPAIRED IN HIV-1 TRANSGENIC RATS VIA A PPAR gamma-DEPENDENT PATHWAY
    Volume: 65 Page(s): 616 - 616
    02/01/2017 Authors: Staitieh B; Grunwell J; Fan X; Guidot D; Yeligar S
  • TAT SIGNIFICANTLY IMPAIRS ANTIOXIDANT AND INNATE IMMUNE DEFENSES IN ALVEOLAR MACROPHAGES
    Volume: 65 Page(s): 559 - 559
    02/01/2017 Authors: Kukoyi A; Staitieh B; Fan X; Guidot D
  • ZINC AND S-ADENOSYLMETHIONINE MEDIATE LUNG INFLAMMATORY CYTOKINES IN OTHERWISE HEALTHY HIV-1-INFECTED INDIVIDUALS
    Volume: 65 Page(s): 614 - 614
    02/01/2017 Authors: Hazariwala V; Guidot D; Brown L; Harris F; Haber M; Cribbs SK
  • ACTIVATION OF NRF2 ATTENUATES MIR-21 AND RESTORES SMAD7 EXPRESSION IN ALCOHOL-EXPOSED LUNG FIBROBLASTS
    Volume: 65 Page(s): 570 - 571
    02/01/2017 Authors: Marts L; Green D; Guidot D; Sueblinvong V
  • ACTIVATION OF NRF2 ATTENUATES MIR-21 AND RESTORES SMAD7 EXPRESSION IN ALCOHOL-EXPOSED LUNG FIBROBLASTS
    Volume: 65 Page(s): 561 - 561
    02/01/2017 Authors: Marts L; Green D; Guidot D; Sueblinvong V
  • Mitochondrial Function In Alveolar Macrophages Is Impaired In Hiv-1 Transgenic Rats Via A Ppar-gamma-Dependent Pathway
    Volume: 195
    01/01/2017 Authors: Staitieh BS; Grunwell JR; Fan X; Guidot DM; Yeligar SM
  • Alcohol and the Lung.
    Alcohol Res Volume: 38 Page(s): 243 - 254
    01/01/2017 Authors: Mehta AJ; Guidot DM
  • The Hiv-1 Trans-Activator Of Transcription (tat) Protein Significantly Impairs Antioxidant And Innate Immune Defenses In Alveolar Macrophages
    Volume: 195
    01/01/2017 Authors: Kukoyi AT; Staitieh BS; Fan X; Guidot DM
  • Activation Of Nrf2 Appears To Prevent Alcohol-Mediated Induction Of Tgf beta 1 By Suppressing Mir-21 And Restoring Smad7 Expression
    Volume: 195
    01/01/2017 Authors: Marts L; Green DE; Mills S; Murphy T; Guidot DM; Sueblinvong V
  • Hiv-Related Proteins Prolong Macrophage Survival Through Induction Of Triggering Receptor Expressed On Myeloid Cells-1
    Volume: 195
    01/01/2017 Authors: Yuan Z; Fan X; Staitieh BS; Bedi B; Spearman P; Guidot DM; Sadikot RT
  • Maternal Alcohol Use During Pregnancy and Associated Morbidities in Very Low Birth Weight Newborns.
    Am J Med Sci Volume: 352 Page(s): 368 - 375
    10/01/2016 Authors: Gauthier TW; Guidot DM; Kelleman MS; McCracken CE; Brown LAS
  • Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis.
    Alcohol Clin Exp Res Volume: 40 Page(s): 1846 - 1856
    09/01/2016 Authors: Sueblinvong V; Mills ST; Neujahr DC; Go Y-M; Jones DP; Guidot DM
  • Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions.
    Nat Commun Volume: 7 Page(s): 12276
    07/25/2016 Authors: Schlingmann B; Overgaard CE; Molina SA; Lynn KS; Mitchell LA; Dorsainvil White S; Mattheyses AL; Guidot DM; Capaldo CT; Koval M
  • Only Jesus Can Call My Son.
    Am J Med Sci Volume: 351 Page(s): 623 - 624
    06/01/2016 Authors: Guidot DM
  • ALCOHOL INDUCES LUNG FIBROBLAST SENESCENCE VIA INDUCTION OF DNMTS.
    Volume: 64 Page(s): 679 - 679
    02/01/2016 Authors: Neveu WA; Mills ST; Guidot DM; Sueblinvong V
  • HIV-1 TRANSGENE EXPRESSION IMPAIRS THE RESPONSE OF ALVEOLAR MACROPHAGES TO EXOGENOUS OXIDATIVE STRESS
    Volume: 64 Page(s): 628 - 628
    02/01/2016 Authors: Ramonell R; Egea E; Fan X; Staitieh B; Guidot DM
  • HIV-1 TRANSGENE EXPRESSION IMPAIRS THE RESPONSE OF ALVEOLAR MACROPHAGES TO EXOGENOUS OXIDATIVE STRESS
    Volume: 64 Page(s): 637 - 637
    02/01/2016 Authors: Ramonell R; Egea E; Fan X; Staitieh B; Guidot DM
  • HIV-RELATED VIRAL PROTEINS IMPAIR NRF2 FUNCTION AND INCREASE OXIDATIVE STRESS IN ALVEOLAR MACROPHAGES
    Volume: 64 Page(s): 679 - 679
    02/01/2016 Authors: Egea E; Fan X; Staitieh B; Guidot DM
  • ALVEOLAR MACROPHAGES FROM HIV-1 TRANSGENIC RATS DEMONSTRATE ABNORMAL BUT REVERSIBLE POLARIZATION
    Volume: 64 Page(s): 678 - 678
    02/01/2016 Authors: Staitieh B; Egea E; Fan X; Neveu WA; Guidot DM
  • Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection.
    Microbiome Volume: 4 Page(s): 3
    01/20/2016 Authors: Cribbs SK; Uppal K; Li S; Jones DP; Huang L; Tipton L; Fitch A; Greenblatt RM; Kingsley L; Guidot DM
  • Maternal Alcohol Use And Associated Bpd/death In The Very Low Birthweight Newborn
    Volume: 193
    01/01/2016 Authors: Gauthier TW; Guidot DM; McCracken CE; Kelleman MS; Brown LS
  • Dietary Supplementation With S-Adenosylmethionine And Zinc Attenuates Hiv-Induced Alveolar Macrophage Phagocytic Dysfunction
    Volume: 193
    01/01/2016 Authors: Yeligar SM; Cribbs SK; Guidot DM; Brown LS
  • Antagonistic Interactions Between Tgf beta 1 And Nrf2 In The Alveolar Epithelium Of Hiv-1 Transgenic Rats
    Volume: 193
    01/01/2016 Authors: Fan X; Staitieh B; Raynor R; Guidot DM
  • Hiv-Related Viral Proteins Impair Nrf2 Function And Increase Oxidative Stress In Alveolar Macrophages
    Volume: 193
    01/01/2016 Authors: Egea E; Fan X; Staitieh B; Guidot DM
  • Hiv-Related Viral Proteins Reversibly Impair Gm-Csf Receptor beta Expression In Alveolar Macrophages
    Volume: 193
    01/01/2016 Authors: Staitieh B; Fan X; Egea E; Neveu WA; Guidot DM
  • Activation of Alveolar Macrophages with Interferon- Promotes Antioxidant Defenses via the Nrf2-ARE Pathway.
    J Clin Cell Immunol Volume: 6
    10/01/2015 Authors: Staitieh BS; Egea EE; Fan X; Azih N; Neveu W; Guidot DM
  • Only Jesus Can Call My Son.
    Am J Med Sci
    08/04/2015 Authors: Guidot DM
  • Presentation of the 2015 Founders' Medal Award.
    Am J Med Sci Volume: 350 Page(s): 6 - 8
    07/01/2015 Authors: Guidot DM
  • Presentation of the 2015 Founders' Medal Award.
    Am J Med Sci Volume: 350 Page(s): 6 - 8
    07/01/2015 Authors: Guidot DM
  • The relative balance of GM-CSF and TGF-1 regulates lung epithelial barrier function.
    Am J Physiol Lung Cell Mol Physiol Volume: 308 Page(s): L1212 - L1223
    06/15/2015 Authors: Overgaard CE; Schlingmann B; Dorsainvil White S; Ward C; Fan X; Swarnakar S; Brown LAS; Guidot DM; Koval M
  • Nrf2 regulates PU.1 expression and activity in the alveolar macrophage.
    Am J Physiol Lung Cell Mol Physiol Volume: 308 Page(s): L1086 - L1093
    05/15/2015 Authors: Staitieh BS; Fan X; Neveu W; Guidot DM
  • Alveolar barrier function in alcoholic lung syndrome is impaired by tight junction destabilization.
    Ann Am Thorac Soc Volume: 12 Suppl 1 Page(s): S75 - S76
    03/01/2015 Authors: Schlingmann BL; Ward C; Molina SA; Overgaard CE; Guidot DM; Koval M
  • The role of donor chronic alcohol abuse in the development of primary graft dysfunction in lung transplant recipients.
    Am J Med Sci Volume: 349 Page(s): 117 - 123
    02/01/2015 Authors: Pelaez A; Mitchell PO; Shah NS; Force SD; Elon L; Brown LAS; Guidot DM
  • PU.1 REGULATES NRF2 IN THE ALVEOLAR MACROPHAGE
    Volume: 63 Page(s): 450 - 450
    02/01/2015 Authors: Staitieh B; Fan X; Neveu WA; Guidot DM
  • Tgf beta 1 Regulates Lung Fibroblast-To-Myofibroblast Transdifferentiation By Thy-1 Methylation
    Volume: 191
    01/01/2015 Authors: Neveu W; Mills T; Staitieh B; Guidot DM; Sueblinvong V
  • Nuclear Over-Expression Of Thioredoxin-1 Protects Against Alcohol-Induced Lung Fibroblast-Myofibroblast Transdifferentiation
    Volume: 191
    01/01/2015 Authors: Sueblinvong V; Mills ST; Guidot DM
  • Hiv-1 Decreases Nrf2/anti-Oxidant Response Element (are) Activity And Phagocytic Function In Alveolar Macrophages
    Volume: 191
    01/01/2015 Authors: Fan X; Staitieh B; Neveu W; Ding L; Raynor R; Spearman P; Guidot DM
  • Hiv Infection Induces Nadph Oxidase Expression In Alveolar Macrophages Of Otherwise Healthy Subjects
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 191
    01/01/2015 Authors: Yeligar SM; Guidot DM; Brown LS; Cribbs SK
  • Alveolar Macrophages From Hiv Transgenic Rats Are Skewed Toward M2 Polarization But Are Stimulated To M1 Polarization By Gm-Csf
    Volume: 191
    01/01/2015 Authors: Staitieh B; Fan X; Neveu W; Guidot DM
  • Treatment With S-Adenosylmethionine And Zinc Restores Nrf2 And Nrf2-Antioxidant Response Element-Dependent Gene Expression In Alcohol-Treated Alveolar Macrophages In Vitro
    Volume: 191
    01/01/2015 Authors: Mehta AJ; Guidot DM
  • Pu.1 Regulates Nrf2 In The Alveolar Macrophage
    Volume: 191
    01/01/2015 Authors: Staitieh B; Fan X; Neveu W; Guidot DM
  • Correction: Placental Fatty Acid Ethyl Esters Are Elevated with Maternal Alcohol Use in Pregnancies Complicated by Prematurity.
    PLoS One Volume: 10 Page(s): e0136366
    01/01/2015 Authors: Gauthier TW; Mohan SS; Gross TS; Harris FL; Guidot DM; Brown LAS
  • Placental Fatty Acid ethyl esters are elevated with maternal alcohol use in pregnancies complicated by prematurity.
    PLoS One Volume: 10 Page(s): e0126552
    01/01/2015 Authors: Gauthier TW; Mohan SS; Gross TS; Harris FL; Guidot DM; Brown LAS
  • NF-B inhibitors impair lung epithelial tight junctions in the absence of inflammation.
    Tissue Barriers Volume: 3 Page(s): e982424
    01/01/2015 Authors: Ward C; Schlingmann B; Stecenko AA; Guidot DM; Koval M
  • Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages.
    AIDS Res Hum Retroviruses Volume: 31 Page(s): 64 - 70
    01/01/2015 Authors: Cribbs SK; Lennox J; Caliendo AM; Brown LA; Guidot DM
  • Noninfectious pulmonary complications of human immunodeficiency virus infection.
    Am J Med Sci Volume: 348 Page(s): 502 - 511
    12/01/2014 Authors: Staitieh B; Guidot DM
  • Donor alcohol abuse and lung injury following allograft transplantation: a cautionary tale but also a call to action.
    Alcohol Clin Exp Res Volume: 38 Page(s): 2695 - 2696
    11/01/2014 Authors: Guidot DM
  • TGF1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts.
    Alcohol Clin Exp Res Volume: 38 Page(s): 2731 - 2742
    11/01/2014 Authors: Sueblinvong V; Tseng V; Smith T; Saghafi R; Mills ST; Neujahr DC; Guidot DM
  • Nuclear over-expression of thioredoxin-1 protects against alcohol-induced lung fibroblast-myofibroblast transdifferentiation
    Volume: 48 Page(s): 734 - 734
    11/01/2014 Authors: Sueblinvong V; Mills ST; Guidot DM
  • Presentation of the 2014 Founders' Medal Award.
    Am J Med Sci Volume: 348 Page(s): 6 - 7
    07/01/2014 Authors: Guidot DM
  • Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1-infected subjects from controls.
    AIDS Res Hum Retroviruses Volume: 30 Page(s): 579 - 585
    06/01/2014 Authors: Cribbs SK; Park Y; Guidot DM; Martin GS; Brown LA; Lennox J; Jones DP
  • Claudin-5 increases alveolar permeability in alcoholic lung syndrome by destabilizing claudin-18/zonula occludens-1 interactions
    FASEB JOURNAL Volume: 28
    04/01/2014 Authors: Schlingmann B; Ward C; Molina S; Overgaard C; Guidot D; Koval M
  • Claudin-5 destabilizes claudin-18/zonula occludens-1 interactions in alveolar epithelial cells and decreases alveolar barrier function during alcoholic lung syndrome
    ACTA PHYSIOLOGICA Volume: 210 Page(s): 58 - 60
    03/01/2014 Authors: Schlingmann B; Ward C; Molina S; Overgaard C; Guidot D; Koval M
  • HEALTHY HIV-INFECTED INDIVIDUALS HARBOR HIV IN THEIR ALVEOLAR MACROPHAGES
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 62 Page(s): 511 - 511
    02/01/2014 Authors: Cribbs SK; Lennox J; Caliendo A; Brown L; Guidot D
  • Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice.
    Alcohol Clin Exp Res Volume: 38 Page(s): 336 - 343
    02/01/2014 Authors: Sueblinvong V; Kerchberger VE; Saghafi R; Mills ST; Fan X; Guidot DM
  • THE DEFENSE PATHWAYS ACTIVATED BY THE TRANSCRIPTION FACTORS NRF2 AND PU.1 APPEAR TO BE COORDINATELY REGULATED IN THE ALVEOLAR MACROPHAGE
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 62 Page(s): 542 - 543
    02/01/2014 Authors: Staitieh B; Fan X; Guidot D
  • HIV-RELATED PROTEINS INHIBIT THE NRF2/ARE SIGNALING PATHWAY IN ALVEOLAR MACROPHAGES
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 62 Page(s): 499 - 500
    02/01/2014 Authors: Singh M; Fan X; Guidot D
  • HEALTHY HIV-INFECTED INDIVIDUALS HARBOR HIV IN THEIR ALVEOLAR MACROPHAGES
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 62 Page(s): 542 - 542
    02/01/2014 Authors: Cribbs SK; Lennox J; Caliendo A; Brown L; Guidot D
  • Transforming Growth Factor beta 1-Induced Epigenetic Modification Of Thy-1 In Primary Lung Fibroblasts
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 189
    01/01/2014 Authors: Neveu W; Sueblinvong V; Guidot DM
  • Atf3 Expression Correlates With Chronic But Not Acute Alcohol-Mediated Suppression Of Nrf2-Are Activity By Tgf beta 1
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 189
    01/01/2014 Authors: Tseng V; Guidot DM; Sueblinvong V
  • Nrf2 And Pu. 1 Are Coordinately Regulated In The Alveolar Macrophage
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 189
    01/01/2014 Authors: Staitieh B; Fan X; Guidot DM
  • Hiv Infection And Smoking Compound Alveolar Oxidative Stress
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 189
    01/01/2014 Authors: Cribbs SK; Wongtrakool C; Brown L; Guidot DM; Crothers KA
  • Hiv Infection Induces Dysregulation Of Ppar-gamma And Tgf-beta In Alveolar Macrophages Of Otherwise Healthy Subjects
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 189
    01/01/2014 Authors: Yeligar SM; Guidot DM; Brown LS; Cribbs SK
  • Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations
    Volume: 14 Page(s): 7 - 10
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Disruption in the Dynamic Balance Between Transforming Growth Factor-beta and Granulocyte/Macrophage Colony-Stimulating Factor Signaling Within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function
    Volume: 14 Page(s): 155 - 171
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Alcohol Use Disorders and the Lung A Clinical and Pathophysiological Approach Preface
    Volume: 14 Page(s): V - VI
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury.
    Adv Biosci Biotechnol Volume: 5 Page(s): 19 - 30
    01/01/2014 Authors: Sueblinvong V; Neveu WA; Neujahr DC; Mills ST; Rojas M; Roman J; Guidot DM
  • Anti-retroviral therapy is associated with decreased alveolar glutathione levels even in healthy HIV-infected individuals.
    PLoS One Volume: 9 Page(s): e88630
    01/01/2014 Authors: Cribbs SK; Guidot DM; Martin GS; Lennox J; Brown LA
  • Alcohol-Mediated Zinc Deficiency Within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung
    Volume: 14 Page(s): 173 - 184
    01/01/2014 Authors: Mehta AJ; Guidot DM
  • Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction.
    Am J Respir Crit Care Med Volume: 188 Page(s): 716 - 723
    09/15/2013 Authors: Mehta AJ; Yeligar SM; Elon L; Brown LA; Guidot DM
  • Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.
    Am J Physiol Lung Cell Mol Physiol Volume: 305 Page(s): L267 - L277
    08/01/2013 Authors: Fan X; Staitieh BS; Jensen JS; Mould KJ; Greenberg JA; Joshi PC; Koval M; Guidot DM
  • REDUCTIONS TO GENES INVOLVED IN OXIDATIVE PHOSPHORYLATION ARE IMPROVED IN MUSCLES FROM ALCOHOL-FED MICE PROVIDED FREE ACCESS TO RUNNING WHEELS
    Volume: 37 Page(s): 56A - 56A
    06/01/2013 Authors: Otis JS; Dekeyser GJ; Guidot DM
  • Nicotinic acetylcholine receptors are sensors for ethanol in lung fibroblasts.
    Alcohol Clin Exp Res Volume: 37 Page(s): 914 - 923
    06/01/2013 Authors: Ritzenthaler JD; Roser-Page S; Guidot DM; Roman J
  • Alcohol ingestion disrupts alveolar epithelial barrier function by activation of macrophage-derived transforming growth factor beta1.
    Respir Res Volume: 14 Page(s): 39
    04/02/2013 Authors: Curry-McCoy TV; Venado A; Guidot DM; Joshi PC
  • Alcohol causes alveolar epithelial oxidative stress by inhibiting the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element signaling pathway.
    Am J Respir Cell Mol Biol Volume: 48 Page(s): 511 - 517
    04/01/2013 Authors: Jensen JS; Fan X; Guidot DM
  • Zinc supplementation increases expression of transcription factors PU.1, KLF4, and Nrf2 in the lungs of alcohol-fed rats
    FASEB JOURNAL Volume: 27
    04/01/2013 Authors: Joshi PC; Fan X; Koval M; Guidot DM
  • Chronic alcohol ingestion in rats decreases Krppel-like factor 4 expression and intracellular zinc in the lung.
    Alcohol Clin Exp Res Volume: 37 Page(s): 361 - 371
    03/01/2013 Authors: Curry-McCoy TV; Guidot DM; Joshi PC
  • HIV-MEDIATED INHIBITION OF PU.1 GENE EXPRESSION IN THE ALVEOLAR EPITHELIUM DOES NOT APPEAR TO BE MEDIATED BY NRF2
    Volume: 61 Page(s): 439 - 439
    02/01/2013 Authors: Staitieh B; Fan X; Guidot D
  • ALCOHOL INDUCES LUNG FIBROBLAST OXIDATIVE STRESS VIA TRANSFORMING GROWTH FACTOR-beta 1 ACTIVATION AND NRF2 SUPPRESSION
    Volume: 61 Page(s): 480 - 480
    02/01/2013 Authors: Sueblinvong V; Saghafi R; Mills S; Fan X; Guidot D
  • Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development.
    Pulm Circ Volume: 3 Page(s): 58 - 67
    01/01/2013 Authors: Porter KM; Walp ER; Elms SC; Raynor R; Mitchell PO; Guidot DM; Sutliff RL
  • Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.
    PLoS One Volume: 8 Page(s): e62792
    01/01/2013 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
  • Metabolomic Profiles In Bronchoalveolar Lavage Fluid Differentiate Otherwise Healthy Hiv-1-Infected Subjects From Healthy Controls
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
    01/01/2013 Authors: Cribbs SK; Park Y; Guidot DM; Martin GS; Jones D
  • Hiv-Mediated Inhibition Of Pu.1 Gene Expression In The Alveolar Epithelium Does Not Appear To Be Mediated By Nrf2
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
    01/01/2013 Authors: Staitieh B; Fan X; Guidot DM
  • A Prospective Observational Study Of Vitamin D And Hospital-Acquired Infections In A Medical Intensive Care Unit
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
    01/01/2013 Authors: Kempker JA; West KG; Alvarez JA; Siwamogsatham O; Ziegler TR; Tangpricha V; Guidot DM; Martin GS
  • Alcohol-Induced Oxidative Stress In Lung Fibroblasts Appears To Involve An Imbalance Between Nrf2 And Thioredoxin-1 In The Nuclear Compartment
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
    01/01/2013 Authors: Staitieh B; Saghafi R; Mills ST; Fan X; Guidot DM; Sueblinvong V
  • Predisposition for disrepair in the aged lung.
    Am J Med Sci Volume: 344 Page(s): 41 - 51
    07/01/2012 Authors: Sueblinvong V; Neujahr DC; Mills ST; Roser-Page S; Ritzenthaler JD; Guidot D; Rojas M; Roman J
  • Recruitment and retention in academic medicine--what junior faculty and trainees want department chairs to know.
    Am J Med Sci Volume: 344 Page(s): 24 - 27
    07/01/2012 Authors: Kubiak NT; Guidot DM; Trimm RF; Kamen DL; Roman J
  • THE PULMONARY COMPLICATIONS OF ALCOHOL ABUSE: COMMON AND DEADLY
    Volume: 36 Page(s): 344A - 344A
    06/01/2012 Authors: Guidot DM; Joshi PC; Mehta AJ; Brown LS
  • Increased claudin-5 increases lung epithelial permeability and is associated with disruption of tight junction assembly
    FASEB JOURNAL Volume: 26
    04/01/2012 Authors: Overgaard C; Mitchell LA; Ward C; Guidot DM; Koval M
  • Alcohol abuse, the alveolar macrophage and pneumonia.
    Am J Med Sci Volume: 343 Page(s): 244 - 247
    03/01/2012 Authors: Mehta AJ; Guidot DM
  • CHRONIC ALCOHOL INGESTION ENHANCES LUNG FIBROSIS FOLLOWING BLEOMYCIN-INDUCED LUNG INJURY IN MICE
    Volume: 60 Page(s): 452 - 452
    01/01/2012 Authors: Kerchberger VE; Fan X; Saghafi R; Mills T; Sueblinvong V; Guidot D
  • TREATMENT WITH SULFORAPHANE, AN ACTIVATOR OF NRF2, PREVENTS ALCOHOL-INDUCED TRANSFORMING GROWTH FACTOR-beta 1 EXPRESSION IN MOUSE FIBROBLASTS
    Volume: 60 Page(s): 422 - 422
    01/01/2012 Authors: Saghafi R; Fan X; Mills T; Guidot D; Sueblinvong V
  • HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung.
    AIDS Res Ther Volume: 8 Page(s): 36
    10/06/2011 Authors: Joshi PC; Guidot DM
  • Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
    Alcohol Clin Exp Res Volume: 35 Page(s): 1866 - 1875
    10/01/2011 Authors: Fan X; Joshi PC; Koval M; Guidot DM
  • Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats.
    Alcohol Clin Exp Res Volume: 35 Page(s): 1519 - 1528
    08/01/2011 Authors: Mehta AJ; Joshi PC; Fan X; Brown LAS; Ritzenthaler JD; Roman J; Guidot DM
  • GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR AND TRANSFORMING GROWTH FACTOR beta HAVE OPPOSING EFFECTS ON LUNG EPITHELIAL BARRIER FUNCTION
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 35 Page(s): 177A - 177A
    06/01/2011 Authors: Overgaard CE; Ward C; Guidot DM; Koval M
  • ALCOHOL-INDUCED CROSSTALK BETWEEN THE IMMUNE AND THE REDOX SYSTEMS IN ALVEOLAR MACROPHAGES: IMPACT OF ZINC SUPPLEMENTATION
    Volume: 35 Page(s): 177A - 177A
    06/01/2011 Authors: Joshi PC; Guidot DM
  • CHRONIC ALCOHOL ABUSE DRIVES P27KIP1 AND REDD1 EXPRESSION IN ATROPHIED PLANTARIS MUSCLES FROM OTHERWISE HEALTHY AND HIV-1 TRANSGENIC RATS
    Volume: 35 Page(s): 52A - 52A
    06/01/2011 Authors: Clary CR; Guidot DM; Otis JS
  • ALCOHOL-MEDIATED ALVEOLAR BARRIER DYSFUNCTION IS MEDIATED BY THE NRF2-REGULATED ANTIOXIDANT RESPONSE ELEMENT
    Volume: 35 Page(s): 50A - 50A
    06/01/2011 Authors: Jensen JS; Fan X; Guidot DM
  • ALCOHOL MODULATES THE EXPRESSION AND DNA BINDING OF KRUPPEL-LIKE TRANSCRIPTION FACTOR 4 IN ALVEOLAR CELLS
    Volume: 35 Page(s): 177A - 177A
    06/01/2011 Authors: Curry-McCoy TV; Guidot DM; Joshi PC
  • CHRONIC ALCOHOL INGESTION AND/OR HIV-1 TRANSGENE EXPRESSION DECREASES NRF2 EXPRESSION IN ALVEOLAR EPITHELIAL CELLS
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 35 Page(s): 178A - 178A
    06/01/2011 Authors: Fan X; Joshi PC; Raynor R; Mills ST; Koval M; Guidot DM
  • Linda Lucetta "Lindy" Wolfenden, MD, 1970-2010 IN MEMORIAM
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES Volume: 341 Page(s): 339 - 339
    05/01/2011 Authors: Guidot D
  • Alcohol-mediated decrease in Kruppel-like transcription factor 4 (KLF4) and its effects on zinc levels in alveolar cells
    Volume: 25
    04/01/2011 Authors: Curry-McCoy TV; Guidot DM; Joshi PC
  • Activation of membrane TGF beta 1 on alveolar macrophages by co-cultured alcohol primed alveolar epithelial cells
    Volume: 186
    04/01/2011 Authors: Joshi P; Venado A; Curry-McCoy T; Guidot D
  • Alcohol-induced alterations of alveolar macrophage transforming growth factor beta 1 (TGF beta 1) levels decrease epithelial barrier function
    Volume: 25
    04/01/2011 Authors: Curry-McCoy TV; Guidot DM; Joshi PC
  • UP-REGULATION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS APPEARS TO MEDIATE ALCOHOL-INDUCED ALVEOLAR MACROPHAGE IMMUNE DYSFUNCTION
    Volume: 59 Page(s): 529 - 529
    02/01/2011 Authors: Co C; Quintero D; Guidot D
  • THE HIV-1 VIRAL PROTEIN gp120 INCREASES ALVEOLAR EPITHELIAL PERMEABILITY THROUGH DOWN-REGULATION OF Nrf2
    Volume: 59 Page(s): 469 - 470
    02/01/2011 Authors: Mould K; Fan X; Guidot D
  • THE HIV-1 VIRAL PROTEIN GP120 INCREASES ALVEOLAR EPITHELIAL PERMEABILITY THROUGH DOWN-REGULATION OF NRF2
    Volume: 59 Page(s): 497 - 497
    02/01/2011 Authors: Mould K; Fan X; Guidot D
  • ALCOHOL-INDUCED OXIDATIVE STRESS AND EPITHELIAL BARRIER DYSFUNCTION APPEARS TO BE MEDIATED BY INHIBITING EXPRESSION OF NRF2, THE TRANSCRIPTION FACTOR THAT ACTIVATES THE ANTIOXIDANT RESPONSE ELEMENT
    Volume: 59 Page(s): 529 - 530
    02/01/2011 Authors: Jensen S; Fan X; Guidot D
  • EPITHELIAL-MACROPHAGE CELLULAR INTERACTION IS ESSENTIAL FOR ACTIVATION OF GROWTH FACTOR-beta 1 IN THE ALCOHOLIC LUNG
    Volume: 59 Page(s): 527 - 527
    02/01/2011 Authors: Venado A; Joshi P; Guidot D
  • Activation Of The NRF2/ARE Pathway Protects Against Oxidative Stress And Alveolar Epithelial Barrier Dysfunction In HIV-1 Transgenic Rats
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 183
    01/01/2011 Authors: Fan X; Joshi PC; Koval M; Guidot DM
  • Up-Regulation Of The Receptor For Advanced Glycation End-Products Appears To Mediate Alcohol-Induced Alveolar Macrophage Immune Dysfunction
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 183
    01/01/2011 Authors: Co CG; Quintero DA; Guidot DM
  • Role Of Thy-1 Negative Fibroblasts In Bleomycin-Induced Fibrosis In Senescent Murine Lungs
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 183
    01/01/2011 Authors: Sueblinvong V; Neujahr DC; Guidot D; Roman J; Rojas M
  • Hiv Infection Decreases Alveolar Macrophage Function, Alters Zinc Bioavailability And Increases Oxidative Stress Even In Otherwise Healthy Individuals
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 183
    01/01/2011 Authors: Cribbs SK; Martin GS; Brown LA; Joshi PC; Guidot DM
  • Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 13848 - 13853
    08/03/2010 Authors: Vikulina T; Fan X; Yamaguchi M; Roser-Page S; Zayzafoon M; Guidot DM; Ofotokun I; Weitzmann MN
  • A sigh of relief about treating influenza in individuals with alcohol-use disorders?
    Alcohol Clin Exp Res Volume: 34 Page(s): 1432
    08/01/2010 Authors: Guidot DM
  • Alcoholic Myopathy: The Effects Of Glutathione Replacement Therapy In A Rat Model Of Abstinence
    Volume: 42 Page(s): 824 - 824
    05/01/2010 Authors: Otis JS; Guidot DM
  • Receptor for advanced glycation end products in donor lungs is associated with primary graft dysfunction after lung transplantation.
    Am J Transplant Volume: 10 Page(s): 900 - 907
    04/01/2010 Authors: Pelaez A; Force SD; Gal AA; Neujahr DC; Ramirez AM; Naik PM; Quintero DA; Pileggi AV; Easley KA; Echeverry R
  • HIV-1-related proteins decrease Nrf2 expression and alter tight junction protein localization in the plasma membranes of cultured alveolar epithelial cells
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Fan X; Joshi P; Koval M; Guidot DM
  • CHRONIC ALCOHOL INGESTION INCREASES EXPRESSION OF THE RECEPTOR FOR ADVANCE GLYCATION END (RAGE) PRODUCTS IN RAT ALVEOLAR MACROPHAGES
    Volume: 58 Page(s): 492 - 492
    02/01/2010 Authors: Quintero DA; Joshi P; Guidot D
  • MESENCHYMAL STEM CELLS MODULATE THE SYSTEMIC INFLAMMATORY RESPONSE TO ENDOTOXEMIA IN ALCOHOL-FED MICE
    Volume: 58 Page(s): 492 - 492
    02/01/2010 Authors: Co C; Guidot D; Rojas M
  • Focus on the lung.
    Alcohol Res Health Volume: 33 Page(s): 219 - 228
    01/01/2010 Authors: Quintero D; Guidot DM
  • EXPRESSION PROFILE OF ZINC TRANSPORTERS AND METALLOTHIONEIN IN THE ALVEOLAR MACROPHAGE AND ITS MODULATION BY ZINC AND ALCOHOL
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 181
    01/01/2010 Authors: Kempker J; Joshi PC; Guidot DM
  • RAGE KNOCK-OUT MICE ARE PROTECTED FROM ALCOHOL-INDUCED IMPAIRMENT OF ALVEOLAR MACROPHAGE PHAGOCYTIC FUNCTION
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 181
    01/01/2010 Authors: Quintero DB; Guidot DM
  • Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence.
    Alcohol Alcohol Volume: 45 Page(s): 495 - 500
    01/01/2010 Authors: Otis JS; Guidot DM
  • Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.
    Alcohol Clin Exp Res Volume: 33 Page(s): 1450 - 1459
    08/01/2009 Authors: Otis JS; Guidot DM
  • Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats.
    Am J Respir Cell Mol Biol Volume: 41 Page(s): 207 - 216
    08/01/2009 Authors: Joshi PC; Mehta A; Jabber WS; Fan X; Guidot DM
  • PROCYSTEINE STIMULATES EXPRESSION OF KEY ANABOLIC FACTORS IN PLANTARIS MUSCLES FROM ALCOHOL-FED RATS
    Volume: 33 Page(s): 278A - 278A
    06/01/2009 Authors: Otis JS; Guidot DM
  • OXIDATIVE STRESS AND ALVEOLAR MACROPHAGE DYSFUNCTION IN THE ALCOHOLIC LUNG
    Volume: 33 Page(s): 289A - 289A
    06/01/2009 Authors: Guidot DM; Mehta AJ; Brown LAS; Joshi PC
  • Chronic alcohol ingestion alters zinc homeostasis along the gut-pulmonary axis and decreases bacterial clearance in the lung
    JOURNAL OF IMMUNOLOGY Volume: 182
    04/01/2009 Authors: Joshi PC; Mehta A; Guidot DM
  • IL-6 family members are sensitive to alcohol-induced oxidant stress in rat plantaris muscles
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Otis JS; Guidot DM
  • Alcohol primes the airway for increased interleukin-13 signaling.
    Alcohol Clin Exp Res Volume: 33 Page(s): 505 - 513
    03/01/2009 Authors: Mitchell PO; Jensen JS; Ritzenthaler JD; Roman J; Pelaez A; Guidot DM
  • HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction.
    AIDS Res Ther Volume: 6 Page(s): 1
    02/04/2009 Authors: Lassiter C; Fan X; Joshi PC; Jacob BA; Sutliff RL; Jones DP; Koval M; Guidot DM
  • Chronic Alcohol Ingestion Decreases Protein Expression of the Receptor for Advanced Glycation End Products in the Rat Lung.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 179
    01/01/2009 Authors: Quintero D; Mitchell PO; Guidot DM
  • Receptor for Advanced Glycation End Products (RAGE) Levels Are Increased in Donor Lungs That Develop Primary Graft Dysfunction Post-Transplantation.
    Volume: 9 Page(s): 290 - 290
    01/01/2009 Authors: Pelaez A; Force SD; Lawrence EC; Ramirez AM; Neujahr DC; Gal AA; Quintero DA; Easley KA; Guidot DM; Mitchell PO
  • ZINC SUPPLEMENTATION IMPROVES SEVERITY OF KLEBSIELLA PNEUMONIAE PNEUMONIA IN THE SETTING OF CHRONIC ALCOHOL INGESTION IN RATS
    Volume: 57 Page(s): 387 - 388
    01/01/2009 Authors: Mehta AJ; Joshi PC; Guidot DM
  • Zinc Supplementation Restores GM-CSF Signaling in the Alveolar Macrophage and Facilitates Clearance of Klebsiella pneumoniae in the Lungs of Alcohol-Fed Rats
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 179
    01/01/2009 Authors: Mehta AJ; Joshi PC; Fan X; Guidot DM
  • CHRONIC ALCOHOL EXPOSURE MODULATES EXPRESSION OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN THE RAT LUNG
    Volume: 57 Page(s): 388 - 388
    01/01/2009 Authors: Quintero D; Pelaez A; Mitchell PO; Guidot DM
  • HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis.
    Am J Respir Cell Mol Biol Volume: 39 Page(s): 218 - 226
    08/01/2008 Authors: Joshi PC; Raynor R; Fan X; Guidot DM
  • Chronic alcohol ingestion in rats decreases zinc bioavailability in the alveolar space
    Volume: 32 Page(s): 225A - 225A
    06/01/2008 Authors: Mehta AJ; Guidot DM; Joshi PC
  • Alcohol augments the impairment of tight junction protein expression and increases permeability in the lung eipthelium of HIV-1 transgenic rats
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 32 Page(s): 224A - 224A
    06/01/2008 Authors: Fan X; Lassiter C; Joshi PC; Koval M; Guidot DM
  • Alcohol primes the airway for increased interleukin-13 signaling and epithelial-mesenchymal transition
    Volume: 32 Page(s): 225A - 225A
    06/01/2008 Authors: Mitchell PO; Jensen JS; Guidot DM
  • Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
    Am J Physiol Heart Circ Physiol Volume: 294 Page(s): H2792 - H2804
    06/01/2008 Authors: Kline ER; Kleinhenz DJ; Liang B; Dikalov S; Guidot DM; Hart CM; Jones DP; Sutliff RL
  • Chronic alcohol ingestion induces several factors associated with skeletal muscle protein degradation in HIV-1 transgenic rats
    Volume: 32 Page(s): 223A - 223A
    06/01/2008 Authors: Otis JS; Guidot DM
  • Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats.
    AIDS Res Ther Volume: 5 Page(s): 8
    04/25/2008 Authors: Otis JS; Ashikhmin YI; Brown LAS; Guidot DM
  • Claudin-5 decreases alveolar epithelial barrier function
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Findley MK; Ward C; Smith T; Guidot DM; Margulies SS; Koval MH
  • HIV-1 transgenic expression in rats alters tight junction protein expression and increases permeability in the lung epithelium
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Fan X; Lassiter C; Joshi PC; Koval M; Guidot DM
  • The expression of zinc transporters and metallothionein is decreased in the intestinal and alveolar epithelium of chronic alcohol-fed rats
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Joshi PC; Guidot DM
  • Na,K-ATPase expression is increased in the lungs of alcohol-fed rats.
    Alcohol Clin Exp Res Volume: 32 Page(s): 699 - 705
    04/01/2008 Authors: Otis JS; Mitchell PO; Kershaw CD; Joshi PC; Guidot DM
  • Zinc deficiency suppresses alveolar macrophage function in in vivo models of both chronic alcohol ingestion and HIV-1 transgenic expression
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Joshi PC; Guidot DM
  • Evidence of epithelial to mesenchymal transition associated with airway remodeling after experimental and clinical lung transplantation
    Volume: 27 Page(s): S250 - S250
    02/01/2008 Authors: Mitchell PO; Naik PM; Neujahr DC; Force SD; Ramirez AM; Gal AA; Lawrence EC; Guidot DM; Pelaez A
  • Prevalence of alcohol use disorders among patients admitted to the medical intensive care unit
    Volume: 56 Page(s): 450 - 450
    01/01/2008 Authors: Prout M; Guidot D; Martin G
  • Alcoholic lung disease.
    Alcohol Res Health Volume: 31 Page(s): 66 - 75
    01/01/2008 Authors: Kershaw CD; Guidot DM
  • Zinc supplementation improves alveolar macrophage immune function in the alcoholic rat lung
    Volume: 56 Page(s): 449 - 449
    01/01/2008 Authors: Melita AJ; Joshi P; Guidot D
  • Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat.
    Alcohol Clin Exp Res Volume: 32 Page(s): 148 - 154
    01/01/2008 Authors: Kleinhenz DJ; Sutliff RL; Polikandriotis JA; Walp ER; Dikalov SI; Guidot DM; Hart CM
  • Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.
    Muscle Nerve Volume: 36 Page(s): 842 - 848
    12/01/2007 Authors: Otis JS; Brown LAS; Guidot DM
  • Alcohol ingestion by donors amplifies experimental airway disease after heterotopic transplantation.
    Am J Respir Crit Care Med Volume: 176 Page(s): 1161 - 1168
    12/01/2007 Authors: Mitchell PO; Guidot DM
  • Alcohol abuse and acute lung injury: can we target therapy?
    Expert Rev Respir Med Volume: 1 Page(s): 197 - 207
    10/01/2007 Authors: Prout M; Martin GS; Drexler K; Brown LAS; Guidot DM
  • Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats.
    Alcohol Volume: 41 Page(s): 371 - 379
    08/01/2007 Authors: Fernandez AL; Koval M; Fan X; Guidot DM
  • Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.
    Alcohol Volume: 41 Page(s): 317 - 324
    08/01/2007 Authors: Brown LAS; Ritzenthaler JD; Guidot DM; Roman J
  • Alcohol-induced oxidative stress may stimulate the atrogin-1/TGF beta 1 pathway and initiate the onset of alcoholic myopathy
    Volume: 31 Page(s): 93A - 93A
    06/01/2007 Authors: Otis JS; Brown LAS; Guidot DM
  • Oxidative stress downregulates expression of GM-CSF receptor on the alcoholic alveolar macrophages: Role of transforming growth factor beta
    Volume: 31 Page(s): 95A - 95A
    06/01/2007 Authors: Joshi PC; Brown LAS; Guidot DM
  • Alcohol induces atrogin-1, an E3 ligase implicated in muscle atrophy, in the myocardium of HIV-1 transgenic and wild type rats
    Volume: 31 Page(s): 93A - 93A
    06/01/2007 Authors: Ashikhmin YI; Otis JS; Guidot DM
  • Alcohol ingestion by donors amplifies experimental obliterative bronchiolitis in a rat model of lung transplantation
    Volume: 31 Page(s): 219A - 219A
    06/01/2007 Authors: Mitchell PO; Guidot DM
  • Alterations in alveolar epithelial tight junctions induced by chronic alcohol ingestion
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 31 Page(s): 94A - 94A
    06/01/2007 Authors: Johnson LN; Fernandez AL; Joshi PC; Guidot DM; Koval M
  • Increased glutathione availability rescues alveolar macrophage function in the rat model of chronic ethanol ingestion
    Volume: 31 Page(s): 310A - 310A
    06/01/2007 Authors: Brown LAS; Tang SM; Guidot DM; Gauthier TW
  • Alcohol-induced oxidant stress alters occludin expression and myosin light chain phosphorylation in the lung epithelium
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 31 Page(s): 94A - 94A
    06/01/2007 Authors: Fan X; Raynor R; Mills ST; Koval M; Guidot DM
  • The alcoholic lung: epidemiology, pathophysiology, and potential therapies.
    Am J Physiol Lung Cell Mol Physiol Volume: 292 Page(s): L813 - L823
    04/01/2007 Authors: Joshi PC; Guidot DM
  • Immunorestorative effect of intranasal granulocyte/macrophage colony stimulating factor (GM-CSF) on alcoholic lung macrophages is mediated through local release of zinc
    JOURNAL OF IMMUNOLOGY Volume: 178
    04/01/2007 Authors: Joshi PC; Guidot DM
  • Impact of zinc deficiency on the alveolar epithelial barrier function
    Volume: 21 Page(s): A170 - A170
    04/01/2007 Authors: Joshi PC; Jabber W; Guidot DM
  • Atrogin-1 and IGF-1 mRNA expressions are altered in plantaris muscles from Human Immunodeficiency Virus-1 (HIV) transgenic rats fed an alcohol diet
    Volume: 21 Page(s): A946 - A946
    04/01/2007 Authors: Otis JS; Guidot DM
  • Chronic alcohol ingestion by donors amplifies obliterative bronchiolitis in a rodent model of lung transplantation
    JOURNAL OF HEART AND LUNG TRANSPLANTATION Volume: 26 Page(s): S197 - S197
    02/01/2007 Authors: Mitchell PO; Guidot DM
  • Zinc supplementation improves alveolar epithelial barrier function in the alcoholic rat lung.
    Volume: 55 Page(s): S288 - S288
    01/01/2007 Authors: Jaber WS; Joshi PC; Guidot DM
  • Hiv-1 transgenic expression in rats impairs alveolar epithelial barrier function.
    Volume: 55 Page(s): S289 - S289
    01/01/2007 Authors: Lassiter C; Joshi PC; Giudot DM
  • Modulation of the interleukin-13 signaling pathway in the rat alcoholic lung.
    Volume: 55 Page(s): S289 - S289
    01/01/2007 Authors: Jensen IS; Mitchell PO; Guidot DM
  • GM-CSF receptor expression and signaling is decreased in lungs of ethanol-fed rats.
    Am J Physiol Lung Cell Mol Physiol Volume: 291 Page(s): L1150 - L1158
    12/01/2006 Authors: Joshi PC; Applewhite L; Mitchell PO; Fernainy K; Roman J; Eaton DC; Guidot DM
  • Integrating acute lung injury and regulation of alveolar fluid clearance.
    Am J Physiol Lung Cell Mol Physiol Volume: 291 Page(s): L301 - L306
    09/01/2006 Authors: Guidot DM; Folkesson HG; Jain L; Sznajder JI; Pittet J-F; Matthay MA
  • Dampened GM-CSF signaling and impaired innate immune function in alveolar macrophages in the alcoholic lung
    Volume: 39 Page(s): 114 - 114
    06/01/2006 Authors: Guidot DM; Joshi PC; Brown LA; Eaton D-AC; Roman J
  • Chronic ethanol ingestion exacerbates redox stress and lung epithelial dysfunction in HIV-1 transgenic rats.
    Volume: 30 Page(s): 67A - 67A
    06/01/2006 Authors: Jacob BA; Lassiter CC; Brown LAS; Sutliff R; Guidot DM
  • Chronic ethanol ingestion by donors predisposes the lung to injury in a rat model of lung transplantation.
    Volume: 30 Page(s): 224A - 224A
    06/01/2006 Authors: Mitchell PO; Guidot DM
  • Granulocyte/macrophage colony-stimulating factor receptors are expressed throughout the lung epithelium in rats and are decreased in the alveolar space by chronic ethanol ingestion.
    Volume: 30 Page(s): 73A - 73A
    06/01/2006 Authors: Guidot DM; Femainy K; Joshi PC; Roman J
  • IHV-1 transgenic expression exacerbates ethanol-induced changes in GM-CSF receptor beta expression in the alveolar macrophage
    Volume: 176 Page(s): S80 - S81
    04/01/2006 Authors: Joshi P; Lassiter C; Guidot D
  • Cytokines and alcohol.
    Alcohol Clin Exp Res Volume: 30 Page(s): 720 - 730
    04/01/2006 Authors: Crews FT; Bechara R; Brown LA; Guidot DM; Mandrekar P; Oak S; Qin L; Szabo G; Wheeler M; Zou J
  • Alterations in alveolar epithelial tight junctions induced by chronic ethanol ingestion
    FASEB JOURNAL Volume: 20 Page(s): A751 - A751
    03/06/2006 Authors: Koval M; Fernandez AL; Joshi PC; Guidot DM
  • Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung.
    Am J Respir Cell Mol Biol Volume: 34 Page(s): 314 - 319
    03/01/2006 Authors: Polikandriotis JA; Rupnow HL; Elms SC; Clempus RE; Campbell DJ; Sutliff RL; Brown LAS; Guidot DM; Hart CM
  • HIV-1 transgenic expression in rats impairs alveolar epithelial barrier function.
    Volume: 54 Page(s): S297 - S297
    01/01/2006 Authors: Lassiter CC; Joshi PC; Brown LAS; Guidot DM
  • Effect of chronic ethanol ingestion by rats on lung tight junction proteins.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 54 Page(s): S310 - S310
    01/01/2006 Authors: Fernandez AL; Koval MH; Joshi PC; Werner KP; Guidot DM
  • Ischemia-reperfusion injury is increased in ethanol-fed donor rats following 2 hours of ischemia in an isolated perfused lung model.
    Volume: 54 Page(s): S309 - S309
    01/01/2006 Authors: Kershaw CD; Garcia RC; Guidot DM
  • Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage (vol 175, pg 6837, 2005)
    JOURNAL OF IMMUNOLOGY Volume: 175 Page(s): 8439 - 8439
    12/15/2005 Authors: Joshi PC; Applewhite L; Ritzenthaler JD; Roman J; Fernandez AL; Eaton DC; Brown LAS; Guidot DM
  • Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage.
    J Immunol Volume: 175 Page(s): 6837 - 6845
    11/15/2005 Authors: Joshi PC; Applewhite L; Ritzenthaler JD; Roman J; Fernandez AL; Eaton DC; Brown LAS; Guidot DM
  • Angiotensin II mediates glutathione depletion, transforming growth factor-beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung.
    Am J Physiol Lung Cell Mol Physiol Volume: 289 Page(s): L363 - L370
    09/01/2005 Authors: Bechara RI; Pelaez A; Palacio A; Joshi PC; Hart CM; Brown LAS; Raynor R; Guidot DM
  • Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats.
    Alcohol Clin Exp Res Volume: 29 Page(s): 1457 - 1465
    08/01/2005 Authors: Kamat PP; Slutsky A; Zhang H; Bechara RI; Brown LAS; Garcia RC; Joshi PC; Kershaw CD; Guidot DM
  • Alcohol abuse and acute lung injury: epidemiology and pathophysiology of a recently recognized association.
    J Investig Med Volume: 53 Page(s): 235 - 245
    07/01/2005 Authors: Guidot DM; Hart CM
  • The effects of chronic ethanol ingestion on rat alveolar macrophage expression of the granulocyte/macrophage colony-stimulating factor receptor and PU.1
    Volume: 36 Page(s): 130 - 130
    06/01/2005 Authors: Joshi PC; Brown LAS; Guidot DM
  • Impaired cytokine regulation renders the alcoholic lung susceptible to injury from both aberrant immune activation and immune suppression
    Volume: 29 Page(s): 193A - 193A
    05/01/2005 Authors: Guidot D; Bechara R; Brown L
  • Ethanol stimulates the expression of fibronectin in lung fibroblasts via kinase-dependent signals that activate CREB.
    Am J Physiol Lung Cell Mol Physiol Volume: 288 Page(s): L975 - L987
    05/01/2005 Authors: Roman J; Ritzenthaler JD; Bechara R; Brown LA; Guidot D
  • Chronic ethanol ingestion up-regulates active sodium transport in the lung.
    Volume: 29 Page(s): 144A - 144A
    05/01/2005 Authors: Garcia RC; Kershaw CD; Guidot DM
  • Chronic ethanol ingestion alters superoxide production in the lung by a renin-angiotensin system-dependent pathway.
    Volume: 29 Page(s): 52A - 52A
    05/01/2005 Authors: Polikandriotie JA; Rupnow HL; Brown LAS; Guidot DM; Hart CM
  • Granulocyte-macrophage colony-stimulating factor receptor expression is decreased in macrophages of ethanol-fed rats.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 53 Page(s): S327 - S327
    01/01/2005 Authors: Fernandez AL; Joshi PC; Guidot DM
  • The renin angiotensin system mediates chronic ethanol-induced increases in superoxide production and NADPH oxidase expression in the lung.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 53 Page(s): S287 - S287
    01/01/2005 Authors: Polikandriots JA; Rupnow HL; Sutliff RL; Brown LS; Guidot DM; Hart CM
  • Granulocyte-macrophage colony-stimulating factor treatment decreases sepsis-mediated acute lung injury in ethanol-fed rats.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 53 Page(s): S327 - S327
    01/01/2005 Authors: Kershaw C; Pelaez A; Guidot DM
  • Influenza virus inhibits ENaC and lung fluid clearance.
    Am J Physiol Lung Cell Mol Physiol Volume: 287 Page(s): L366 - L373
    08/01/2004 Authors: Chen X-J; Seth S; Yue G; Kamat P; Compans RW; Guidot D; Brown LA; Eaton DC; Jain L
  • Alcohol and alveolar epithelial dysfunction.
    Volume: 28 Page(s): 70A - 70A
    08/01/2004 Authors: Guidot D
  • Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung.
    Am J Respir Crit Care Med Volume: 170 Page(s): 188 - 194
    07/15/2004 Authors: Bechara RI; Brown LAS; Roman J; Joshi PC; Guidot DM
  • Alveolar macrophage dysfunction in the alcoholic rat lung is associated with impaired granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling.
    Volume: 28 Page(s): 129A - 129A
    05/01/2004 Authors: Applewhite L; Brown LAS; Garcia R; Joshi PC; Guidot DM
  • Granulocyte/macrophage colony-stimulating factor (GM-CSF) restores bacterial phagocytosis in alveolar macrophages from ethenol-fed rats.
    Volume: 28 Page(s): 37A - 37A
    05/01/2004 Authors: Kamat PP; Brown LAS; Garcia R; Joshi P; Guidot DM
  • Ethanol induces alveolar type II cells to deposit a matrix that promotes monocyte activation
    Volume: 28 Page(s): 123A - 123A
    05/01/2004 Authors: Roman J; Ritzenthaler JD; Guidot DM; Brown LAS
  • Granulocyte/macrophage colony-stimulating factor treatment improves alveolar epithelial barrier function in alcoholic rat lung.
    Am J Physiol Lung Cell Mol Physiol Volume: 286 Page(s): L106 - L111
    01/01/2004 Authors: Pelaez A; Bechara RI; Joshi PC; Brown LAS; Guidot DM
  • Angiotensin II inhibition improves alveolar epithelial barrier function in the alcoholic rat lung.
    Volume: 52 Page(s): S317 - S317
    01/01/2004 Authors: Palacio AF; Pelaez A; Joshi PC; Guidot DM; Bechara R
  • Effects of chronic ethanol ingestion on NADPH oxidase expression in the lung in vivo.
    Volume: 52 Page(s): S317 - S317
    01/01/2004 Authors: Rupnow HL; Clempus RE; Greindling KK; Brown LS; Guidot DM; Hart CM
  • Chronic ethanol ingestion impairs granulocyte-macrhophage colony stimulating factor (GM-CSF) signaling in the rat lung.
    Volume: 52 Page(s): S317 - S318
    01/01/2004 Authors: Pelaez A; Brown LS; Joshi PC; Applewhite L; Bechara RI; Guidot DM
  • Chronic ethanol ingestion impairs bacterial phagocytosis by alveolar macrophages during mechanical ventilation in a rat model.
    Volume: 52 Page(s): S317 - S317
    01/01/2004 Authors: Kamat PP; Bechara RI; Brown LS; Guidot DM
  • Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells.
    Alcohol Clin Exp Res Volume: 27 Page(s): 1006 - 1014
    06/01/2003 Authors: Bechara RI; Brown LAS; Eaton DC; Roman J; Guidot DM
  • Pulmonary alveolar proteinosis mimicking idiopathic pulmonary fibrosis.
    Ann Diagn Pathol Volume: 7 Page(s): 82 - 86
    04/01/2003 Authors: Arbiser ZK; Guidot DM; Pine JR; Giltman LI; Gal AA
  • Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock.
    Crit Care Med Volume: 31 Page(s): 869 - 877
    03/01/2003 Authors: Moss M; Parsons PE; Steinberg KP; Hudson LD; Guidot DM; Burnham EL; Eaton S; Cotsonis GA
  • Mechanisms of alcohol-induced tissue injury.
    Alcohol Clin Exp Res Volume: 27 Page(s): 563 - 575
    03/01/2003 Authors: Molina PE; Hoek JB; Nelson S; Guidot DM; Lang CH; Wands JR; Crawford JM
  • Chronic ethanol ingestion impairs alveolar macrophage immune function in vitro,and cytokine release during mechanical ventilation ex vivo.
    Volume: 51 Page(s): S279 - S279
    02/01/2003 Authors: Kamat PP; Brown LS; Slutsky A; Guidot DM; Bechara RI
  • Chronic ethanol ingestion impairs alveolar macrophage immune function in vitro, and cytokine release during mechanical ventilation ex vivo.
    Volume: 51 Page(s): S293 - S294
    02/01/2003 Authors: Kamat PP; Brown LS; Slutsky A; Guidot DM; Bechara RI
  • Chronic ethanol ingestion in rats increases apical sodium channel-dependent alveolar liquid clearance, which may compensate for ethanol-induced alveolar epithelial permeability.
    Volume: 51 Page(s): S269 - S269
    02/01/2003 Authors: Kamat PP; Jain L; Eaton DC; Bechara RI; Guidot DM
  • Chronic ethanol ingestion, via angiotensin II, causes oxidative stress and induces expression of transforming growth factor beta in the rat lung: A proposed mechanism for alcohol-mediated lung injury.
    Volume: 51 Page(s): S294 - S294
    02/01/2003 Authors: Bechara RI; Brown LS; Guidot DM
  • Chronic ethanol ingestion increases susceptibility to acute lung injury: role of oxidative stress and tissue remodeling.
    Chest Volume: 122 Page(s): 309S - 314S
    12/01/2002 Authors: Guidot DM; Roman J
  • Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats.
    Alcohol Clin Exp Res Volume: 26 Page(s): 1245 - 1251
    08/01/2002 Authors: Velasquez A; Bechara RI; Lewis JF; Malloy J; McCaig L; Brown LAS; Guidot DM
  • GeneChip microarray analyses to study chronic alcoholism-induced lung inflammation.
    Volume: 16 Page(s): A181 - A181
    03/20/2002 Authors: Bowman M; Patel V; Hite R; Smith K; Culpepper C; Mudumbi K; Guidot D; Polavarapu R
  • Molecular pathology and clinical aspects of alcohol-induced tissue injury.
    Alcohol Clin Exp Res Volume: 26 Page(s): 120 - 128
    01/01/2002 Authors: Molina PE; McClain C; Valla D; Guidot D; Diehl AM; Lang CH; Neuman M
  • Chronic ethanol ingestion potentiates TNF-alpha-mediated oxidative stress and apoptosis in rat type II cells.
    Am J Physiol Lung Cell Mol Physiol Volume: 281 Page(s): L377 - L386
    08/01/2001 Authors: Brown LA; Harris FL; Guidot DM
  • Effect of chronic ethanol ingestion on alveolar type II cell: glutathione and inflammatory mediator-induced apoptosis.
    Alcohol Clin Exp Res Volume: 25 Page(s): 1078 - 1085
    07/01/2001 Authors: Brown LA; Harris FL; Bechara R; Guidot DM
  • Chronic ethanol ingestion decreases glutathione and increases protein in the epithelial lining fluid of rats.
    FASEB JOURNAL Volume: 15 Page(s): A859 - A859
    03/08/2001 Authors: Brown LAS; Moss M; Guidot DM
  • Ethanol ingestion, via glutathione depletion, impairs alveolar epithelial function and renders the lung susceptible to acute injury during oxidative stress
    Volume: 336 Page(s): 174 - 185
    01/01/2001 Authors: Guidot DM; Moss M; Brown LAS
  • Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats.
    Alcohol Clin Exp Res Volume: 24 Page(s): 1070 - 1076
    07/01/2000 Authors: Guidot DM; Brown LA
  • Diabetic patients have a decreased incidence of acute respiratory distress syndrome.
    Crit Care Med Volume: 28 Page(s): 2187 - 2192
    07/01/2000 Authors: Moss M; Guidot DM; Steinberg KP; Duhon GF; Treece P; Wolken R; Hudson LD; Parsons PE
  • Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.
    Am J Physiol Lung Cell Mol Physiol Volume: 279 Page(s): L127 - L135
    07/01/2000 Authors: Guidot DM; Modelska K; Lois M; Jain L; Moss IM; Pittet JF; Brown LA
  • The effects of chronic alcohol abuse on pulmonary glutathione homeostasis.
    Am J Respir Crit Care Med Volume: 161 Page(s): 414 - 419
    02/01/2000 Authors: Moss M; Guidot DM; Wong-Lambertina M; Ten Hoor T; Perez RL; Brown LA
  • Ethanol ingestion, via mitochondrial depletion of glutathione, renders the alveolar epithelium susceptible to apoptosis.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 48 Page(s): 154A - 154A
    01/01/2000 Authors: Bechara R; Velasquez A; Brown LA; Guidot DM
  • Ethanol ingestion alters extracellular matrix remodeling in rat lungs.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 48 Page(s): 128A - 128A
    01/01/2000 Authors: Bechara R; Velasquez A; Lois M; Brown LA; Roman J; Guidot DM
  • Chronic ethanol ingestion alters surfactant composition and increases acute lung injury in septic rats.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 48 Page(s): 173A - 173A
    01/01/2000 Authors: Velasquez A; Brown LA; Lewis JF; Malloy J; McCaig LA; Guidot DM
  • Mitochondrial antioxidant function is a potential mechanism for organ differences in interleukin-1-mediated tolerance to oxidative injury.
    Am J Med Sci Volume: 318 Page(s): 308 - 315
    11/01/1999 Authors: Guidot DM; Kitlowski AD; Hybertson BM; Repine JE
  • Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia.
    Am J Respir Crit Care Med Volume: 160 Page(s): 1354 - 1360
    10/01/1999 Authors: Lois M; Brown LA; Moss IM; Roman J; Guidot DM
  • Ethanol ingestion impairs alveolar epithelial glutathione homeostasis and function, and predisposes to endotoxin-mediated acute lung injury.
    Chest Volume: 116 Page(s): 82S
    07/01/1999 Authors: Guidot D; Moss M; Holguin F; Lois M; Brown L
  • The effect of chronic alcohol abuse on the incidence of ARDS and the severity of the multiple organ dysfunction syndrome in adults with septic shock: an interim and multivariate analysis.
    Chest Volume: 116 Page(s): 97S - 98S
    07/01/1999 Authors: Moss M; Steinberg KP; Guidot DM; Duhon GF; Treece P; Wolken R; Hudson LD; Parsons PE
  • Maternal ethanol ingestion decreases fetal lung glutathione and surfactant homeostasis.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 159 Page(s): A153 - A153
    03/01/1999 Authors: Brown LAS; Harris FL; Guidot DM; Gauthier TW
  • Glutathione levels are decreased in the alveolar lining fluid of the lung from patients with cirrhosis.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 159 Page(s): A376 - A376
    03/01/1999 Authors: TenHoor TL; Brown LAS; Guidot DM; Moss M
  • Alcohol consumption of greater than three times per week is associated with an increased proportionate mortality ratio from the acute respiratory distress syndrome (ARDS).
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 159 Page(s): A717 - A717
    03/01/1999 Authors: Ten Hoor TL; Mannino DM; Guidot DM; Moss M
  • Ethanol ingestion impairs alveolar epithelial barrier function in rats.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 159 Page(s): A594 - A594
    03/01/1999 Authors: Lois M; Moss IM; Modelska K; Brown LS; Jain L; Pittet JF; Guidot DM
  • Endotoxin pretreatment in vivo increases the mitochondrial respiratory capacity in rat hepatocytes.
    Arch Biochem Biophys Volume: 354 Page(s): 9 - 17
    06/01/1998 Authors: Guidot DM
  • Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats.
    J Clin Invest Volume: 101 Page(s): 761 - 768
    02/15/1998 Authors: Holguin F; Moss I; Brown LA; Guidot DM
  • Ethanol ingestion increases gelatinase activity and acute edematous injury in lungs isolated from endotoxin-treated rats.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 16A - 16A
    01/01/1998 Authors: Lois M; Roman J; Moss IM; Guidot DM
  • Does increased mitochondrial biogenesis explain the phenomenon of acquired tolerance to oxidative stress?
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 17A - 17A
    01/01/1998 Authors: Guidot DM
  • Ethanol ingestion decreases alveolar type II cell mitochondrial glutathione levels and impairs surfactant secretion and viability in vitro: A proposed mechanism by which chronic alcoholism predisposes to acute lung injury.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 17A - 17A
    01/01/1998 Authors: Holguin F; Moss IM; Brown LS; Guidot DM
  • Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs.
    Am J Physiol Volume: 273 Page(s): L957 - L966
    11/01/1997 Authors: Guidot DM; Bursten SL; Rice GC; Chaney RB; Singer JW; Repine AJ; Hybertson BM; Repine JE
  • Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs.
    Am J Physiol Lung Cell Mol Physiol Volume: 273 Page(s): L957 - L966
    11/01/1997 Authors: Guidot DM; Bursten SL; Rice GC; Chaney RB; Singer JW; Repine AJ; Hybertson BM; Repine JE
  • Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs.
    Am J Physiol Volume: 271 Page(s): L225 - L229
    08/01/1996 Authors: Guidot DM; Hybertson BM; Kitlowski RP; Repine JE
  • Endotoxin treatment increases lung mitochondrial scavenging of extramitochondrial superoxide in hyperoxia-exposed rats.
    Arch Biochem Biophys Volume: 326 Page(s): 266 - 270
    02/15/1996 Authors: Guidot DM
  • In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase.
    Chem Biol Volume: 2 Page(s): 741 - 750
    11/01/1995 Authors: Smith D; Kirschenheuter GP; Charlton J; Guidot DM; Repine JE
  • Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism.
    J Clin Invest Volume: 96 Page(s): 1131 - 1136
    08/01/1995 Authors: Guidot DM; Repine JE; Kitlowski AD; Flores SC; Nelson SK; Wright RM; McCord JM
  • INHALED NITRIC-OXIDE PREVENTS NEUTROPHIL-MEDIATED, OXYGEN RADICAL-DEPENDENT LEAK IN ISOLATED RAT LUNGS
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY Volume: 269 Page(s): L2 - L5
    07/01/1995 Authors: GUIDOT DM; REPINE MJ; HYBERTSON BM; REPINE JE
  • Inhaled nitric oxide prevents neutrophil-mediated, oxygen radical-dependent leak in isolated rat lungs.
    Am J Physiol Volume: 269 Page(s): L2 - L5
    07/01/1995 Authors: Guidot DM; Repine MJ; Hybertson BM; Repine JE
  • Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice.
    J Exp Med Volume: 181 Page(s): 569 - 575
    02/01/1995 Authors: Abraham E; Bursten S; Shenkar R; Allbee J; Tuder R; Woodson P; Guidot DM; Rice G; Singer JW; Repine JE
  • Interleukin-1 treatment increases neutrophils but not antioxidant enzyme activity or resistance to ischemia-reperfusion injury in rat kidneys.
    Inflammation Volume: 18 Page(s): 537 - 545
    10/01/1994 Authors: Guidot DM; Linas SL; Repine MJ; Shanley PF; Fisher HS; Repine JE
  • Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
    Proc Natl Acad Sci U S A Volume: 91 Page(s): 8156 - 8159
    08/16/1994 Authors: Guidot DM; Repine MJ; Westcott JY; Repine JE
  • INTRINSIC NEUTROPHIL NADPH OXIDASE AND 5-LIPOXYGENASE ACTIVITY ARE BOTH REQUIRED FOR INTERLEUKIN-8-MEDIATED INJURY IN ISOLATED-PERFUSED RAT LUNGS
    CLINICAL RESEARCH Volume: 42 Page(s): A145 - A145
    04/01/1994 Authors: GUIDOT DM; REPINE MJ; WESTCOTT JY; REPINE JE
  • INHIBITION OF LYSOPHOSPHATIDIC ACID ACYL TRANSFERASE (LPAAT) ACTIVITY BY CT1501R SUPPRESSES NEUTROPHIL ADHERENCE AND CHEMOTAXIS IN-VITRO AND DECREASES INTERLEUKIN-8 (IL-8)-INDUCED INJURY IN ISOLATED RAT LUNGS PERFUSED WITH HUMAN NEUTROPHILS
    CLINICAL RESEARCH Volume: 42 Page(s): A145 - A145
    04/01/1994 Authors: GUIDOT DM; RICE GC; SINGER JW; BURSTEN S; BIANCO JA; ABRAHAM E; REPINE JE
  • Intratracheal but not intravascular interleukin-1 causes acute edematous injury in isolated neutrophil-perfused rat lungs through an oxygen radical-mediated mechanism.
    J Lab Clin Med Volume: 123 Page(s): 605 - 609
    04/01/1994 Authors: Guidot DM; Stevens EE; Repine MJ; Lucca-Broco AE; Repine JE
  • A DUAL ROLE FOR ELECTRON-TRANSPORT IN CELLULAR OXIDANT-ANTIOXIDANT BALANCE - MITOCHONDRIAL RESPIRATION PRODUCES SUPEROXIDE IN HYPEROXIA BUT SCAVENGES EXTRAMITOCHONDRIAL SUPEROXIDE IN NORMOXIA
    CLINICAL RESEARCH Volume: 42 Page(s): A145 - A145
    04/01/1994 Authors: GUIDOT DM; MCCORD JM; REPINE JE
  • Interleukin-1-induced tolerance to IL-1-induced oxidative lung injury in rats.
    Chest Volume: 105 Page(s): 86S
    03/01/1994 Authors: Guidot D; Repine JE
  • NEUTROPHIL-DERIVED NADPH OXIDASE AND LIPOXYGENASE PRODUCTS MEDIATE DAMAGE IN ISOLATED NEUTROPHIL-PERFUSED RAT LUNGS GIVEN INTERLEUKIN-8 (IL-8) INTRATRACHEALLY
    CLINICAL RESEARCH Volume: 42 Page(s): A5 - A5
    02/01/1994 Authors: REPINE MJ; GUIDOT DM; REPINE JE
  • Absence of electron transport (Rho 0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo.
    J Biol Chem Volume: 268 Page(s): 26699 - 26703
    12/15/1993 Authors: Guidot DM; McCord JM; Wright RM; Repine JE
  • MITOCHONDRIAL RESPIRATION PRODUCES SUPEROXIDE IN HYPEROXIA BUT SCAVENGES EXTRAMITOCHONDRIAL SUPEROXIDE IN NORMOXIA - A DUAL ROLE FOR ELECTRON-TRANSPORT IN CELLULAR OXIDANT-ANTIOXIDANT BALANCE
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 15 Page(s): 540 - 540
    11/01/1993 Authors: GUIDOT DM; REPINE JE; MCCORD JM
  • NEUTROPHIL-DERIVED OXYGEN RADICALS CONTRIBUTE TO ACUTE EDEMATOUS INJURY IN ISOLATED RAT LUNGS GIVEN INTERLEUKIN-1 INTRATRACHEALLY
    CLINICAL RESEARCH Volume: 41 Page(s): A282 - A282
    04/01/1993 Authors: GUIDOT DM; REPINE JE
  • Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity.
    Proc Natl Acad Sci U S A Volume: 89 Page(s): 3362 - 3366
    04/15/1992 Authors: Terada LS; Guidot DM; Leff JA; Willingham IR; Hanley ME; Piermattei D; Repine JE
  • MITOCHONDRIAL RESPIRATION PRODUCES SUPEROXIDE DURING HYPEROXIA BUT SCAVENGES SUPEROXIDE DURING NORMOXIA - EVIDENCE FOR A NOVEL DUAL ROLE FOR ELECTRON-TRANSPORT IN CELLULAR OXIDANT-ANTIOXIDANT BALANCE
    CLINICAL RESEARCH Volume: 40 Page(s): A305 - A305
    04/01/1992 Authors: GUIDOT DM; WRIGHT RM; MCCORD JM; REPINE JE
  • Tungsten treatment prevents tumor necrosis factor-induced injury of brain endothelial cells.
    Inflammation Volume: 16 Page(s): 13 - 19
    02/01/1992 Authors: Terada LS; Willingham IR; Guidot DM; Shibao GN; Kindt GW; Repine JE
  • GENETICALLY ENGINEERED ABSENCE OF MITOCHONDRIAL ELECTRON-TRANSPORT ALLOWS GROWTH OF A MANGANESE SUPEROXIDE-DISMUTASE (MN-SOD) DEFICIENT YEAST IN HYPEROXIA
    CLINICAL RESEARCH Volume: 39 Page(s): A332 - A332
    04/01/1991 Authors: GUIDOT DM; WRIGHT RM; REPINE JE
  • GENETICALLY ENGINEERED ABSENCE OF MITOCHONDRIAL ELECTRON-TRANSPORT ALLOWS GROWTH OF A MANGANESE SUPEROXIDE-DISMUTASE (MN-SOD) DEFICIENT YEAST IN HYPEROXIA
    CLINICAL RESEARCH Volume: 39 Page(s): A107 - A107
    02/01/1991 Authors: GUIDOT DM; WRIGHT RM; REPINE JE
  • Inactivation of xanthine oxidase by hydrogen peroxide involves site-directed hydroxyl radical formation.
    Free Radic Biol Med Volume: 10 Page(s): 61 - 68
    01/01/1991 Authors: Terada LS; Leff JA; Guidot DM; Willingham IR; Repine JE
  • Metals inhibit riboflavin-catalyzed generation of superoxide anion in vitro.
    Inflammation Volume: 14 Page(s): 217 - 221
    04/01/1990 Authors: Terada LS; Leff JA; Guidot DN; Shibao GA; Repine JE
  • Differential Expression of ATF3 and TGF1 During Alcoholic Lung Oxidative Stress
    American Journal of Respiratory and Critical Care Medicine Volume: 2014;189:A3405
    Authors: Tseng V; Sueblinvong V; Guidot DM
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