Publications

• OGA mutant aberrantly hydrolyzes O-GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy.
  Proc Natl Acad Sci U S A Volume: 121 Page(s): e2320867121
  06/11/2024 Authors: Hu C-W; Wang A; Fan D; Worth M; Chen Z; Huang J; Xie J; Macdonald J; Li L; Jiang J
• TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
  J Mol Cell Biol Volume: 15
  08/03/2023 Authors: Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y
• Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.
  Acta Pharmacol Sin Volume: 43 Page(s): 2419 - 2428
  09/01/2022 Authors: Shu C; Zheng X; Wuhafu A; Cicka D; Doyle S; Niu Q; Fan D; Qian K; Ivanov AA; Du Y
• Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
  Cell Volume: 185 Page(s): 1974 - 1985.e12
  05/26/2022 Authors: Mo X; Niu Q; Ivanov AA; Tsang YH; Tang C; Shu C; Li Q; Qian K; Wahafu A; Doyle SP
• Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
  Bioorg Med Chem Volume: 45 Page(s): 116324
  09/01/2021 Authors: Yang X; Fan D; Troha AH; Ahn HM; Qian K; Liang B; Du Y; Fu H; Ivanov AA
• Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.
  Int J Biol Macromol Volume: 169 Page(s): 51 - 59
  02/01/2021 Authors: Kositzke A; Fan D; Wang A; Li H; Worth M; Jiang J
• Targeted covalent inhibition of O-GlcNAc transferase in cells.
  Chem Commun (Camb) Volume: 55 Page(s): 13291 - 13294
  10/31/2019 Authors: Worth M; Hu C-W; Li H; Fan D; Estevez A; Zhu D; Wang A; Jiang J
• Aglycone Ebselen and -d-Xyloside Primed Glycosaminoglycans Co-contribute to Ebselen -d-Xyloside-Induced Cytotoxicity.
  J Med Chem Volume: 61 Page(s): 2937 - 2948
  04/12/2018 Authors: Tang Y; Zhang S; Chang Y; Fan D; Agostini AD; Zhang L; Jiang T
• Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
  Nat Chem Biol Volume: 13 Page(s): 1267 - 1273
  12/01/2017 Authors: Hu C-W; Worth M; Fan D; Li B; Li H; Lu L; Zhong X; Lin Z; Wei L; Ge Y
• Distributive O-GlcNAcylation on the Highly Repetitive C-Terminal Domain of RNA Polymerase II.
  Biochemistry Volume: 55 Page(s): 1149 - 1158
  02/23/2016 Authors: Lu L; Fan D; Hu C-W; Worth M; Ma Z-X; Jiang J
• Exploring stereoselectivity of 3-indolyl cyclopent[b]indoles: a parallel synthesis and anti-EGFR study on human cancer cells.
  Eur J Med Chem Volume: 74 Page(s): 533 - 540
  03/03/2014 Authors: Fan D; Sun W; Qiu P; Wu Z; Li Y; Wan S; Jiang T; Zhang L