Douglas Falls MD

Department of Cell Biology
Associate Professor, Emeritus

(404) 435-3954
dfalls@emory.edu

Academic Appointment

Associate Professor, Medical Educator and Service Track, Department of Cell Biology, Emory University School of Medicine

Education

Degrees

MD from St. Louis University - Cum Laude

Research

Focus

Molecular mechanisms of synapse formation; cell biology of transmembrane signaling proteins; functions and signaling modalities of neuregulin protein isoforms; nervous system progenitor cell biology [Note: I am not currently actively engaged in laboratory research]

Publications

Type III neuregulin-1 promotes oligodendrocyte myelination.
Glia Volume: 56 Page(s): 284 - 293
02/01/2008 Authors: Taveggia C; Thaker P; Petrylak A; Caporaso GL; Toews A; Falls DL; Einheber S; Salzer JL
Subventricular zone neuronal progenitors undergo multiple divisions and retract their processes prior to each cytokinesis.
Eur J Neurosci Volume: 26 Page(s): 593 - 604
08/01/2007 Authors: Coskun V; Falls DL; Lane R; Czirok A; Luskin MB
Antigen-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by HCl pretreatment.
J Neurosci Volume: 27 Page(s): 5837 - 5844
05/30/2007 Authors: Tang X; Falls DL; Li X; Lane T; Luskin MB
Neuregulin-1 type III determines the ensheathment fate of axons.
Neuron Volume: 47 Page(s): 681 - 694
09/01/2005 Authors: Taveggia C; Zanazzi G; Petrylak A; Yano H; Rosenbluth J; Einheber S; Xu X; Esper RM; Loeb JA; Shrager P
Dasm1: a receptor that shapes neuronal dendrites and turns on silent synapses?
Sci STKE Volume: 2005 Page(s): pe10
03/08/2005 Authors: Falls DL
Neuregulins: functions, forms, and signaling strategies.
Exp Cell Res Volume: 284 Page(s): 14 - 30
03/10/2003 Authors: Falls DL
Neuregulins and the neuromuscular system: 10 years of answers and questions.
J Neurocytol Volume: 32 Page(s): 619 - 647
01/01/2003 Authors: Falls DL
Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton.
Rev Neurosci Volume: 14 Page(s): 233 - 240
01/01/2003 Authors: Meng Y; Zhang Y; Tregoubov V; Falls DL; Jia Z
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.
Neuron Volume: 35 Page(s): 121 - 133
07/03/2002 Authors: Meng Y; Zhang Y; Tregoubov V; Janus C; Cruz L; Jackson M; Lu WY; MacDonald JF; Wang JY; Falls DL
The N-terminal region of neuregulin-1 proteins determines cell-surface accumulation in neurons
MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 28A - 28A
11/01/2001 Authors: Falls DL; Wang JY
Neuregulin-1 proteins in rat brain and transfected cells are localized to lipid rafts.
J Neurochem Volume: 77 Page(s): 1 - 12
04/01/2001 Authors: Frenzel KE; Falls DL
The N-terminal region of neuregulin isoforms determines the accumulation of cell surface and released neuregulin ectodomain.
J Biol Chem Volume: 276 Page(s): 2841 - 2851
01/26/2001 Authors: Wang JY; Miller SJ; Falls DL
A protein kinase from neutrophils that specifically recognizes Ser-3 in cofilin.
J Biol Chem Volume: 275 Page(s): 2869 - 2876
01/28/2000 Authors: Lian JP; Marks PG; Wang JY; Falls DL; Badwey JA
LIM kinase 1 accumulates in presynaptic terminals during synapse maturation.
J Comp Neurol Volume: 416 Page(s): 319 - 334
01/17/2000 Authors: Wang JY; Wigston DJ; Rees HD; Levey AI; Falls DL
LIM Kinase 1 is concentrated in adult presynaptic terminals.
MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 231A - 231A
11/01/1999 Authors: Falls DL; Wang JY; Wigston DJ; Rees HD; Levey AI
Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.
J Biol Chem Volume: 273 Page(s): 20525 - 20534
08/07/1998 Authors: Wang JY; Frenzel KE; Wen D; Falls DL
The neuregulin cytoplasmic domain associates with two non-receptor protein kinases
MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 54 - 54
12/01/1996 Authors: Wang J; Thomas K; Wen D; Falls D
Trophic interactions at developing synapses.
Prog Clin Biol Res Volume: 390 Page(s): 173 - 190
01/01/1994 Authors: Fischbach GD; Aratake H; Corfas G; Falls DL; Goodearl A; Rosen KM
ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.
Cell Volume: 72 Page(s): 801 - 815
03/12/1993 Authors: Falls DL; Rosen KM; Corfas G; Lane WS; Fischbach GD
ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein.
Proc Natl Acad Sci U S A Volume: 90 Page(s): 1624 - 1628
02/15/1993 Authors: Corfas G; Falls DL; Fischbach GD
A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.
Proc Natl Acad Sci U S A Volume: 88 Page(s): 7664 - 7668
09/01/1991 Authors: Harris DA; Falls DL; Johnson FA; Fischbach GD
Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor.
Proc Natl Acad Sci U S A Volume: 88 Page(s): 7669 - 7673
09/01/1991 Authors: Martinou JC; Falls DL; Fischbach GD; Merlie JP
Mr 42,000 ARIA: a protein that may regulate the accumulation of acetylcholine receptors at developing chick neuromuscular junctions.
Cold Spring Harb Symp Quant Biol Volume: 55 Page(s): 397 - 406
01/01/1990 Authors: Falls DL; Harris DA; Johnson FA; Morgan MM; Corfas G; Fischbach GD
Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor.
Nature Volume: 337 Page(s): 173 - 176
01/12/1989 Authors: Harris DA; Falls DL; Fischbach GD
Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit.
Proc Natl Acad Sci U S A Volume: 85 Page(s): 1983 - 1987
03/01/1988 Authors: Harris DA; Falls DL; Dill-Devor RM; Fischbach GD
A QUANTITATIVE STUDY OF THE BRANCHING PATTERN OF T-CELL PROCESSES IN HIRUDO MEDICINALIS
Volume: 161 Page(s): 342 - 343
01/01/1981 Authors: FALLS DL; MACAGNO ER

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Douglas Falls MD

Academic Appointment

Education

Degrees

Research

Focus

Publications