Publications

• Nigral volume loss in prodromal, early, and moderate Parkinson's disease.
  NPJ Parkinsons Dis Volume: 11 Page(s): 181
  06/21/2025 Authors: Langley J; Hwang KS; Huddleston DE; Hu XP; Parkinsons Progression Marker Initiative
• Nigral volume loss in prodromal, early, and moderate Parkinson's disease.
  medRxiv
  03/21/2025 Authors: Langley J; Hwang KS; Huddleston DE; Hu XP
• IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study.
  Neurol Neuroimmunol Neuroinflamm Volume: 11 Page(s): e200311
  11/01/2024 Authors: Postuma R; Vorasoot N; St Louis EK; Pelletier A; Lim MM; Elliott J; Gagnon J-F; Gan-Or Z; Forsberg LK; Fields JA
• Concerns with the new biological research criteria for synucleinopathy.
  Lancet Neurol Volume: 23 Page(s): 659 - 660
  07/01/2024 Authors: Boeve BF; Davis AA; Ju Y-E; Kantarci K; Singer W; Videnovic A; NAPS co-investigators
• Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium.
  Sleep Volume: 47
  06/13/2024 Authors: Elliott JE; Ligman BR; Bryant-Ekstrand MD; Keil AT; Powers K; Olivo C; Neilson LE; Postuma RB; Pelletier A; Gagnon J-F
• Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium.
  Neurology Volume: 102 Page(s): e208008
  02/13/2024 Authors: Choudhury P; Lee-Iannotti JK; Busicescu AO; Rangan P; Fantini ML; Avidan AY; Bliwise DL; Criswell SR; During EH; Elliott JE
• Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder.
  Neurology Volume: 101 Page(s): e2545 - e2559
  12/12/2023 Authors: Elliott JE; Bryant-Ekstrand MD; Keil AT; Ligman BR; Lim MM; Zitser J; During EH; Gagnon J-F; St Louis EK; Fields JA
• Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson's disease with freezing of gait.
  medRxiv
  07/06/2023 Authors: Huddleston DE; Chen X; Hwang K; Langley J; Tripathi R; Tucker K; McKay JL; Hu X; Factor SA
• Baseline characteristics of the North American prodromal Synucleinopathy cohort.
  Ann Clin Transl Neurol Volume: 10 Page(s): 520 - 535
  04/01/2023 Authors: Elliott JE; Lim MM; Keil AT; Postuma RB; Pelletier A; Gagnon J-F; St Louis EK; Forsberg LK; Fields JA; Huddleston DE
• Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson's disease with freezing of gait.
  Front Dement Volume: 2 Page(s): 1215505
  01/01/2023 Authors: Huddleston DE; Chen X; Hwang K; Langley J; Tripathi R; Tucker K; McKay JL; Hu X; Factor SA
• In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.
  PLoS One Volume: 18 Page(s): e0282684
  01/01/2023 Authors: Hwang KS; Langley J; Tripathi R; Hu XP; Huddleston DE
• North American prodromal synucleinopathy consortium: baseline characteristics in 251 patients with REM sleep behavior disorder
  Volume: 31
  10/01/2022 Authors: Elliott J; Lim M; Keil A; Avidan A; Bliwise D; Gagnon J-F; Howell M; Huddleston D; McLeland J; Postuma R
• Imaging Neuromelanin and Iron Pathology In Vivo in Neurodegenerative Parkinsonism
  Volume: 92 Page(s): S128 - S129
  10/01/2022 Authors: Huddleston D; Langley J; Chen X; John S; Littrell K; Tucker K; Hu X
• Impact of Locus Coeruleus and Its Projections on Memory and Aging.
  Brain Connect Volume: 12 Page(s): 223 - 233
  04/01/2022 Authors: Langley J; Hussain S; Huddleston DE; Bennett IJ; Hu XP
• Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit.
  Front Neurosci Volume: 16 Page(s): 1048945
  01/01/2022 Authors: Langley J; Hwang KS; Hu XP; Huddleston DE
• Imaging Prodromal Neuromelanin and Iron Pathology in REM Sleep Behavior Disorder
  Volume: 90 Page(s): S94 - S94
  10/01/2021 Authors: Huddleston DE; Kristy HE; Langley J; Hu X; Bliwise D
• Longitudinal changes in nigral neuromelanin in early, levodopa-treated Parkinson's disease
  Volume: 36 Page(s): S358 - S359
  09/01/2021 Authors: Hwang K; Langley J; Kurra N; Factor S; Hu X; Huddleston D
• Locus coeruleus volume is reduced in Parkinson's Disease-related orthostatic hypotension
  MOVEMENT DISORDERS Volume: 36 Page(s): S408 - S409
  09/01/2021 Authors: Beach P; Kurra N; Hwang K; Langley J; Hu X; Huddleston D
• NAPS
  Volume: 44 Page(s): A206 - A207
  05/01/2021 Authors: Elliott J; Lim M; Keil A; Avidan A; Bliwise D; Gagnon J-F; Howell M; Huddleston D; McCleland J; St Louis E
• Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies.
  Cardiol Rev Volume: 29 Page(s): 68 - 72
  03/01/2021 Authors: Catanzaro JN; Chan N; Ismail H; Huddleston D; Makaryus AN; Makaryus JN
• Nigral diffusivity, but not free water, correlates with iron content in Parkinson's disease.
  Brain Commun Volume: 3 Page(s): fcab251
  01/01/2021 Authors: Langley J; Huddleston DE; Hu X
• Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.
  Front Neurol Volume: 12 Page(s): 805135
  01/01/2021 Authors: Scott GD; Arnold MR; Beach TG; Gibbons CH; Kanthasamy AG; Lebovitz RM; Lemstra AW; Shaw LM; Teunissen CE; Zetterberg H
• Multimodal assessment of nigrosomal degeneration in Parkinson's disease.
  Parkinsonism Relat Disord Volume: 80 Page(s): 102 - 107
  11/01/2020 Authors: Langley J; Huddleston DE; Crosson B; Song DD; Factor SA; Hu X
• The North American Prodromal Synucleinopathy (NAPS) Consortium: Baseline Neuropsychological Findings in 70 Participants
  Volume: 94
  04/14/2020 Authors: Fields J; Boeve B; Forsberg L; Louis ES; Kraft R; Nelson K; Timm P; Teigen L; Avidan A; Rivera A
• Increased iron-deposition in lateral-ventral substantia nigra pars compacta: A promising neuroimaging marker for Parkinson's disease.
  Neuroimage Clin Volume: 28 Page(s): 102391
  01/01/2020 Authors: He N; Langley J; Huddleston DE; Chen S; Huang P; Ling H; Yan F; Hu X
• Rationale and Design of the PAIRED Trial: Partnered Dance Aerobic Exercise as a Neuroprotective, Motor, and Cognitive Intervention in Parkinson's Disease.
  Front Neurol Volume: 11 Page(s): 943
  01/01/2020 Authors: Hackney ME; Bay AA; Jackson JM; Nocera JR; Krishnamurthy V; Crosson B; Evatt ML; Langley J; Cui X; McKay JL
• MRI Signatures of Iron Pathology in Parkinson's Disease and Multiple System Atrophy
  Volume: 86 Page(s): S266 - S267
  10/01/2019 Authors: Huddleston D; Mahmoudi B; Langley J; Ellis CA; Factor S; Hu X; Crosson B
• Machine Learning Classification of Parkinson's Disease with Neuromelanin-Sensitive MRI and Clinical Features
  Volume: 86 Page(s): S179 - S179
  10/01/2019 Authors: Huddleston D; Mahmoudi B; Langley J; Ellis C; Tripathi R; Lane M; Wood-Siverio C; Factor S; Hu X; Crosson B
• A Cloud-based Framework for Implementing Portable Machine Learning Pipelines for Neural Data Analysis.
  Volume: 2019 Page(s): 4466 - 4469
  07/01/2019 Authors: Ellis CA; Gu P; Sendi MSE; Huddleston D; Sharma A; Mahmoudi B
• Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings.
  Alzheimers Res Ther Volume: 11 Page(s): 23
  03/13/2019 Authors: Peterson B; Armstrong M; Galasko D; Galvin JE; Goldman J; Irwin D; Paulson H; Kaufer D; Leverenz J; Lunde A
• Reproducible detection of nigral iron deposition in 2 Parkinson's disease cohorts.
  Mov Disord Volume: 34 Page(s): 416 - 419
  03/01/2019 Authors: Langley J; He N; Huddleston DE; Chen S; Yan F; Crosson B; Factor S; Hu X
• Improved Neuroimaging Atlas of the Dentate Nucleus.
  Cerebellum Volume: 16 Page(s): 951 - 956
  12/01/2017 Authors: He N; Langley J; Huddleston DE; Ling H; Xu H; Liu C; Yan F; Hu XP
• In vivo detection of lateral-ventral tier nigral degeneration in Parkinson's disease.
  Hum Brain Mapp Volume: 38 Page(s): 2627 - 2634
  05/01/2017 Authors: Huddleston DE; Langley J; Sedlacik J; Boelmans K; Factor SA; Hu XP
• Advanced Neuromelanin Sensitive MRI Measures Detect Parkinson's Disease Effects in Catecholamine Nuclei: Discovery and Validation in Separate Cohorts
  Volume: 88
  04/18/2017 Authors: Huddleston D; Langley J; McMurray R; De Louis F; Factor S; Hu X
• Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI.
  MAGMA Volume: 30 Page(s): 121 - 125
  04/01/2017 Authors: Langley J; Huddleston DE; Liu CJ; Hu X
• Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta.
  Mov Disord Volume: 32 Page(s): 441 - 449
  03/01/2017 Authors: Langley J; Huddleston DE; Sedlacik J; Boelmans K; Hu XP
• Diffusion tensor imaging of the substantia nigra in Parkinson's disease revisited.
  Hum Brain Mapp Volume: 37 Page(s): 2547 - 2556
  07/01/2016 Authors: Langley J; Huddleston DE; Merritt M; Chen X; McMurray R; Silver M; Factor SA; Hu X
• In vivo MRI detection of Parkinson's disease associated degeneration in the lateral ventral tier of substantia nigra pars compacta
  Volume: 31 Page(s): S435 - S435
  06/01/2016 Authors: Huddleston DE; Langley J; Sedlacik J; Boelmans K; Factor SA; Hu X
• Multimodal Imaging Signatures of Parkinson's Disease.
  Front Neurosci Volume: 10 Page(s): 131
  01/01/2016 Authors: Bowman FD; Drake DF; Huddleston DE
• A multicontrast approach for comprehensive imaging of substantia nigra.
  Neuroimage Volume: 112 Page(s): 7 - 13
  05/15/2015 Authors: Langley J; Huddleston DE; Chen X; Sedlacik J; Zachariah N; Hu X
• Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach.
  Magn Reson Imaging Volume: 32 Page(s): 1301 - 1306
  12/01/2014 Authors: Chen X; Huddleston DE; Langley J; Ahn S; Barnum CJ; Factor SA; Levey AI; Hu X
• Quantitative in vivo MRI measurement of locus coeruleus degeneration in patients with Parkinson's disease
  Volume: 27 Page(s): S239 - S239
  06/01/2012 Authors: Huddleston DE; Chen S; Chen X; Ahn S; Hu X
• Of monkeys and men: analysis of the phase 2 double-blind, sham-surgery controlled, randomized trial of AAV2-neurturin gene therapy for Parkinson's disease.
  Curr Neurol Neurosci Rep Volume: 11 Page(s): 345 - 348
  08/01/2011 Authors: Huddleston DE; Factor SA
• Fever after subarachnoid hemorrhage: risk factors and impact on outcome.
  Neurology Volume: 68 Page(s): 1013 - 1019
  03/27/2007 Authors: Fernandez A; Schmidt JM; Claassen J; Pavlicova M; Huddleston D; Kreiter KT; Ostapkovich ND; Kowalski RG; Parra A; Connolly ES
• An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.
  Proc Natl Acad Sci U S A Volume: 104 Page(s): 5638 - 5643
  03/27/2007 Authors: Pereira AC; Huddleston DE; Brickman AM; Sosunov AA; Hen R; McKhann GM; Sloan R; Gage FH; Brown TR; Small SA
• Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI.
  Nat Clin Pract Neurol Volume: 1 Page(s): 96 - 105
  12/01/2005 Authors: Huddleston DE; Small SA