David Gordon
- Department of Pathology and Laboratory Medicine
Assistant Professor
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1750 Haygood Drive, Room N124 -
1462 Clifton Road, Room 440
Overview
The Gordon laboratory utilizes high-throughput experimental genetics and proteomics to build mechanistic models of biological functions and applies this knowledge to invent new therapeutic treatments. We are interested in all aspects of human biology, with a focus on virology and the human immune system as these offer tractable genetic systems, an ample supply of primary tissues, and opportunities to rapidly test therapeutic interventions.
Dr. Gordon has a diverse research background spanning cell and molecular biology, experimental genetics, proteomics, virology, and systems biology. As a graduate student at the University of Cambridge he applied combinatorial experimental genetics and proteomics to map redundant vesicle trafficking pathways. Later, as a postdoctoral fellow at the University of California San Francisco, he pioneered the use of high-throughput genetic interaction mapping to study HIV host-dependencies. He also spearheaded the first peer-reviewed protein interaction maps of the highly pathogenic coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS. Gordons laboratory builds on lessons learned during these pioneering studies to develop high-throughput experiments in primary systems, to systematically dissect the mechanistic basis of immune functions and infection by pathogens of pandemic concern.
We are affiliated with the Emory University Department of Pathology, which is ranked 6th in the United States in NIH research funding, enabling superb research support and access to state-of-the-art equipment. Based next to the CDC, with ample access to BSL facilities at Emory, we are located at a nexus of infectious disease research, and our location in the Emory Vaccine Center with the Pathology Translational Research Unit provides extraordinary collaboration opportunities with world-leading immunologists. We are within walking distance to Emory University Hospital and the Emory National Primate Center, offering numerous collaborative opportunities in both clinical and animal studies.
Academic Appointment
- Adjunct Assistant Professor, Georgia Institute of Technology
- Assistant Professor, Pathology, Emory University
Education
Degrees
- PhD from University of Cambridge
- MPhil from University of Cambridge
Research
Publications
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Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach.
J Am Chem Soc Volume: 147 Page(s): 7214 - 7230
03/05/2025 Authors: Farhi J; Emenike B; Lee RS; Sad K; Fawwal DV; Beusch CM; Jones RB; Verma AK; Jones CY; Foroozani M -
Acrolein-Mediated Conversion of Lysine to Electrophilic Heterocycles for Protein Diversification and Toxicity Profiling.
J Am Chem Soc Volume: 147 Page(s): 5679 - 5692
02/19/2025 Authors: Paikin ZE; Emenike B; Shirke R; Beusch CM; Gordon DE; Raj M -
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.
Nat Immunol Volume: 25 Page(s): 1245 - 1256
07/01/2024 Authors: Strongin Z; Raymond Marchand L; Deleage C; Pampena MB; Cardenas MA; Beusch CM; Hoang TN; Urban EA; Gourves M; Nguyen K -
Copper(I)-nitrene platform for chemoproteomic profiling of methionine.
Nat Commun Volume: 15 Page(s): 4243
05/18/2024 Authors: Sahu S; Emenike B; Beusch CM; Bagchi P; Gordon DE; Raj M -
The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
Stem Cell Reports Volume: 18 Page(s): 2138 - 2153
11/14/2023 Authors: Maven BEJ; Gifford CA; Weilert M; Gonzalez-Teran B; Httenhain R; Pelonero A; Ivey KN; Samse-Knapp K; Kwong W; Gordon D -
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
Sci Immunol Volume: 8 Page(s): eadg0033
07/28/2023 Authors: Viox EG; Hoang TN; Upadhyay AA; Nchioua R; Hirschenberger M; Strongin Z; Tharp GK; Pino M; Nguyen K; Harper JL -
Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy.
iScience Volume: 26 Page(s): 107056
07/21/2023 Authors: Williams DM; Hornsby HR; Shehata OM; Brown R; Gallis M; Meardon N; Newman TAH; Plowright M; Zafred D; Shun-Shion ASM -
ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling.
J Biol Chem Volume: 297 Page(s): 101393
12/01/2021 Authors: Sargeant J; Seiler DK; Costain T; Madreiter-Sokolowski CT; Gordon DE; Peden AA; Malli R; Graier WF; Hay JC -
Quantitative Flow Cytometry-Based Assays for Measuring Constitutive Secretion.
Methods Mol Biol Volume: 2233 Page(s): 115 - 129
01/01/2021 Authors: Gordon DE; Shun-Shion AS; Asnawi AW; Peden AA -
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science Volume: 370
12/04/2020 Authors: Gordon DE; Hiatt J; Bouhaddou M; Rezelj VV; Ulferts S; Braberg H; Jureka AS; Obernier K; Guo JZ; Batra J