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Profile

David Gordon

  • Department of Pathology and Laboratory Medicine
    Assistant Professor
  • david.ezra.gordon@emory.edu
  • Website

  • 1750 Haygood Drive, Room N124

  • 1462 Clifton Road, Room 440

Overview

The Gordon laboratory utilizes high-throughput experimental genetics and proteomics to build mechanistic models of biological functions and applies this knowledge to invent new therapeutic treatments. We are interested in all aspects of human biology, with a focus on virology and the human immune system as these offer tractable genetic systems, an ample supply of primary tissues, and opportunities to rapidly test therapeutic interventions.

Dr. Gordon has a diverse research background spanning cell and molecular biology, experimental genetics, proteomics, virology, and systems biology. As a graduate student at the University of Cambridge he applied combinatorial experimental genetics and proteomics to map redundant vesicle trafficking pathways. Later, as a postdoctoral fellow at the University of California San Francisco, he pioneered the use of high-throughput genetic interaction mapping to study HIV host-dependencies. He also spearheaded the first peer-reviewed protein interaction maps of the highly pathogenic coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS. Gordons laboratory builds on lessons learned during these pioneering studies to develop high-throughput experiments in primary systems, to systematically dissect the mechanistic basis of immune functions and infection by pathogens of pandemic concern.

We are affiliated with the Emory University Department of Pathology, which is ranked 6th in the United States in NIH research funding, enabling superb research support and access to state-of-the-art equipment. Based next to the CDC, with ample access to BSL facilities at Emory, we are located at a nexus of infectious disease research, and our location in the Emory Vaccine Center with the Pathology Translational Research Unit provides extraordinary collaboration opportunities with world-leading immunologists. We are within walking distance to Emory University Hospital and the Emory National Primate Center, offering numerous collaborative opportunities in both clinical and animal studies.

Academic Appointment

  • Adjunct Assistant Professor, Georgia Institute of Technology
  • Assistant Professor, Pathology, Emory University

Education

Degrees

  • PhD from University of Cambridge
  • MPhil from University of Cambridge

Research

Publications

  • Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach.
    J Am Chem Soc Volume: 147 Page(s): 7214 - 7230
    03/05/2025 Authors: Farhi J; Emenike B; Lee RS; Sad K; Fawwal DV; Beusch CM; Jones RB; Verma AK; Jones CY; Foroozani M
  • Acrolein-Mediated Conversion of Lysine to Electrophilic Heterocycles for Protein Diversification and Toxicity Profiling.
    J Am Chem Soc Volume: 147 Page(s): 5679 - 5692
    02/19/2025 Authors: Paikin ZE; Emenike B; Shirke R; Beusch CM; Gordon DE; Raj M
  • Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.
    Nat Immunol Volume: 25 Page(s): 1245 - 1256
    07/01/2024 Authors: Strongin Z; Raymond Marchand L; Deleage C; Pampena MB; Cardenas MA; Beusch CM; Hoang TN; Urban EA; Gourves M; Nguyen K
  • Copper(I)-nitrene platform for chemoproteomic profiling of methionine.
    Nat Commun Volume: 15 Page(s): 4243
    05/18/2024 Authors: Sahu S; Emenike B; Beusch CM; Bagchi P; Gordon DE; Raj M
  • The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
    Stem Cell Reports Volume: 18 Page(s): 2138 - 2153
    11/14/2023 Authors: Maven BEJ; Gifford CA; Weilert M; Gonzalez-Teran B; Httenhain R; Pelonero A; Ivey KN; Samse-Knapp K; Kwong W; Gordon D
  • Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
    Sci Immunol Volume: 8 Page(s): eadg0033
    07/28/2023 Authors: Viox EG; Hoang TN; Upadhyay AA; Nchioua R; Hirschenberger M; Strongin Z; Tharp GK; Pino M; Nguyen K; Harper JL
  • Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy.
    iScience Volume: 26 Page(s): 107056
    07/21/2023 Authors: Williams DM; Hornsby HR; Shehata OM; Brown R; Gallis M; Meardon N; Newman TAH; Plowright M; Zafred D; Shun-Shion ASM
  • ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling.
    J Biol Chem Volume: 297 Page(s): 101393
    12/01/2021 Authors: Sargeant J; Seiler DK; Costain T; Madreiter-Sokolowski CT; Gordon DE; Peden AA; Malli R; Graier WF; Hay JC
  • Quantitative Flow Cytometry-Based Assays for Measuring Constitutive Secretion.
    Methods Mol Biol Volume: 2233 Page(s): 115 - 129
    01/01/2021 Authors: Gordon DE; Shun-Shion AS; Asnawi AW; Peden AA
  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
    Science Volume: 370
    12/04/2020 Authors: Gordon DE; Hiatt J; Bouhaddou M; Rezelj VV; Ulferts S; Braberg H; Jureka AS; Obernier K; Guo JZ; Batra J
  • The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.
    Cells Volume: 9
    09/01/2020 Authors: Langer S; Yin X; Diaz A; Portillo AJ; Gordon DE; Rogers UH; Marlett JM; Krogan NJ; Young JAT; Pache L
  • The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
    Cell Volume: 182 Page(s): 685 - 712.e19
    08/06/2020 Authors: Bouhaddou M; Memon D; Meyer B; White KM; Rezelj VV; Correa Marrero M; Polacco BJ; Melnyk JE; Ulferts S; Kaake RM
  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
    Nature Volume: 583 Page(s): 459 - 468
    07/01/2020 Authors: Gordon DE; Jang GM; Bouhaddou M; Xu J; Obernier K; White KM; O'Meara MJ; Rezelj VV; Guo JZ; Swaney DL
  • The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.
    Cancer Discov Volume: 10 Page(s): 916 - 921
    07/01/2020 Authors: Tutuncuoglu B; Cakir M; Batra J; Bouhaddou M; Eckhardt M; Gordon DE; Krogan NJ
  • A Quantitative Genetic Interaction Map of HIV Infection.
    Mol Cell Volume: 78 Page(s): 197 - 209.e7
    04/16/2020 Authors: Gordon DE; Watson A; Roguev A; Zheng S; Jang GM; Kane J; Xu J; Guo JZ; Stevenson E; Swaney DL
  • ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
    Cell Host Microbe Volume: 26 Page(s): 86 - 99.e7
    07/10/2019 Authors: Httenhain R; Xu J; Burton LA; Gordon DE; Hultquist JF; Johnson JR; Satkamp L; Hiatt J; Rhee DY; Baek K
  • CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
    EMBO J Volume: 37
    09/14/2018 Authors: Chen S-H; Jang GM; Httenhain R; Gordon DE; Du D; Newton BW; Johnson JR; Hiatt J; Hultquist JF; Johnson TL
  • Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.
    J Exp Med Volume: 215 Page(s): 51 - 62
    01/02/2018 Authors: Jeng MY; Hull PA; Fei M; Kwon H-S; Tsou C-L; Kasler H; Ng C-P; Gordon DE; Johnson J; Krogan N
  • Genetic interaction mapping in mammalian cells using CRISPR interference.
    Nat Methods Volume: 14 Page(s): 577 - 580
    06/01/2017 Authors: Du D; Roguev A; Gordon DE; Chen M; Chen S-H; Shales M; Shen JP; Ideker T; Mali P; Qi LS
  • VAMP3/Syb and YKT6 are required for the fusion of constitutive secretory carriers with the plasma membrane.
    PLoS Genet Volume: 13 Page(s): e1006698
    04/01/2017 Authors: Gordon DE; Chia J; Jayawardena K; Antrobus R; Bard F; Peden AA
  • CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.
    Cell Stem Cell Volume: 18 Page(s): 541 - 553
    04/07/2016 Authors: Mandegar MA; Huebsch N; Frolov EB; Shin E; Truong A; Olvera MP; Chan AH; Miyaoka Y; Holmes K; Spencer CI
  • The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.
    J Neurosci Volume: 35 Page(s): 7643 - 7653
    05/13/2015 Authors: Gokhale A; Mullin AP; Zlatic SA; Easley CA; Merritt ME; Raj N; Larimore J; Gordon DE; Peden AA; Sanyal S
  • A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.
    Mol Cell Volume: 51 Page(s): 519 - 530
    08/22/2013 Authors: Surma MA; Klose C; Peng D; Shales M; Mrejen C; Stefanko A; Braberg H; Gordon DE; Vorkel D; Ejsing CS
  • -Synuclein impairs macroautophagy: implications for Parkinson's disease.
    J Cell Biol Volume: 190 Page(s): 1023 - 1037
    09/20/2010 Authors: Winslow AR; Chen C-W; Corrochano S; Acevedo-Arozena A; Gordon DE; Peden AA; Lichtenberg M; Menzies FM; Ravikumar B; Imarisio S
  • A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells.
    Traffic Volume: 11 Page(s): 1191 - 1204
    09/01/2010 Authors: Gordon DE; Bond LM; Sahlender DA; Peden AA
  • A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.
    EMBO J Volume: 29 Page(s): 304 - 314
    01/20/2010 Authors: Wendler F; Gillingham AK; Sinka R; Rosa-Ferreira C; Gordon DE; Franch-Marro X; Peden AA; Vincent J-P; Munro S
  • Coiled-coil interactions are required for post-Golgi R-SNARE trafficking.
    EMBO Rep Volume: 10 Page(s): 851 - 856
    08/01/2009 Authors: Gordon DE; Mirza M; Sahlender DA; Jakovleska J; Peden AA
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