Chungwen Wei PhD

Department of Medicine
Assistant Professor

(404) 712-2989
chungwen.wei@emory.edu

Overview

Dr. Wei earned his PhD in Biochemistry and received further training in Immunology from the University of Rochester. During his post-doctoral training, he created a line of transgenic mice that express human prostate specific antigen (PSA) in a spatial and temporal pattern that mimics humans', for which he received a US patent. These transgenic mice have been used as a model to study tumor immunotherapy by breaking tolerance to self-antigen. One of his regrets in life is that he does not have a picture of the founder mouse, although any C57BL/6 mouse can pass for it.

His current research is focused on the human B cell development and homeostasis, and the disregulation of these events in the pathogenesis of autoimmune diseases such as lupus. Among the first few labs, he identified a subset of human memory B cells devoid of the conventional CD27memory marker, which is greatly expanded in lupus patients. The link between this subset of memory Bcells and lupus disease is currently under investigation through the characterization of autoreactive B cells and gene profiling analysis. He also pursues a systems biology approach that integrates B cell profiling and clinical parameters to better understand the lupus disease.

Academic Appointment

Assistant Professor of Medicine, Medicine - Rheumatology, Emory University School of Medicine

Education

Degrees

PhD from University of Rochester

Research

Publications

SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs.
Res Sq
06/27/2023 Authors: Chen W; Hong S-H; Jenks SA; Anam FA; Tipton CM; Woodruff MC; Hom JR; Cashman KS; Faliti CE; Wang X
Safety, immunological effects and clinical response in a phase I trial of umbilical cord mesenchymal stromal cells in patients with treatment refractory SLE.
Lupus Sci Med Volume: 9
07/01/2022 Authors: Kamen DL; Wallace C; Li Z; Wyatt M; Paulos C; Wei C; Wang H; Wolf BJ; Nietert PJ; Gilkeson G
B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus.
Ann Rheum Dis Volume: 80 Page(s): 1190 - 1200
09/01/2021 Authors: Jenks SA; Wei C; Bugrovsky R; Hill A; Wang X; Rossi FM; Cashman K; Woodruff MC; Aspey LD; Lim SS
Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.
Nat Commun Volume: 11 Page(s): 1533
03/24/2020 Authors: Commander R; Wei C; Sharma A; Mouw JK; Burton LJ; Summerbell E; Mahboubi D; Peterson RJ; Konen J; Zhou W
Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.
Front Immunol Volume: 10 Page(s): 2458
01/01/2019 Authors: Sanz I; Wei C; Jenks SA; Cashman KS; Tipton C; Woodruff MC; Hom J; Lee FE-H
Clinical Efficacy and Safety of Baminercept, a Lymphotoxin Receptor Fusion Protein, in Primary Sjgren's Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial.
Arthritis Rheumatol Volume: 70 Page(s): 1470 - 1480
09/01/2018 Authors: St Clair EW; Baer AN; Wei C; Noaiseh G; Parke A; Coca A; Utset TO; Genovese MC; Wallace DJ; McNamara J
The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.
J Immunol Volume: 197 Page(s): 3841 - 3849
11/15/2016 Authors: Hart GT; Akkaya M; Chida AS; Wei C; Jenks SA; Tipton C; He C; Wendel BS; Skinner J; Arora G
Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study.
J Proteome Res Volume: 15 Page(s): 2102 - 2114
07/01/2016 Authors: Wu T; Ding H; Han J; Arriens C; Wei C; Han W; Pedroza C; Jiang S; Anolik J; Petri M
ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in nave SLE B cells.
Sci Rep Volume: 6 Page(s): 27030
06/01/2016 Authors: Scharer CD; Blalock EL; Barwick BG; Haines RR; Wei C; Sanz I; Boss JM
Polychromatic flow cytometry in evaluating rheumatic disease patients.
Arthritis Res Ther Volume: 17 Page(s): 561
12/01/2015 Authors: Wei C; Jenks S; Sanz I
Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.
Am J Transplant Volume: 15 Page(s): 2908 - 2920
11/01/2015 Authors: Newell KA; Asare A; Sanz I; Wei C; Rosenberg A; Gao Z; Kanaparthi S; Asare S; Lim N; Stahly M
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.
Nat Immunol Volume: 16 Page(s): 755 - 765
07/01/2015 Authors: Tipton CM; Fucile CF; Darce J; Chida A; Ichikawa T; Gregoretti I; Schieferl S; Hom J; Jenks S; Feldman RJ
B-cell profiling to predict clinical response following Rituximab therapy in patients with autoimmune blistering diseases
Volume: 135 Page(s): S11 - S11
05/01/2015 Authors: Booker S; Bradley B; Neary B; Wei C; Sanz I; Feldman RJ
AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus.
Int J Cancer Volume: 136 Page(s): 1371 - 1380
03/15/2015 Authors: Wilmore JR; Asito AS; Wei C; Piriou E; Sumba PO; Sanz I; Rochford R
Polychromatic flow cytometry in evaluating rheumatic disease patients.
Arthritis Res Ther Volume: 17 Page(s): 46
03/05/2015 Authors: Wei C; Jenks S; Sanz I
Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.
PLoS One Volume: 10 Page(s): e0128269
01/01/2015 Authors: Adlowitz DG; Barnard J; Biear JN; Cistrone C; Owen T; Wang W; Palanichamy A; Ezealah E; Campbell D; Wei C
A B cell riddle: a new tool to study the link between malaria and Burkitt's Lymphoma
JOURNAL OF IMMUNOLOGY Volume: 192
05/01/2014 Authors: Hart G; Wei C; Chida A; Crompton P; Sanz I; Pierce S
High-throughput flow cytometry data normalization for clinical trials.
Cytometry A Volume: 85 Page(s): 277 - 286
03/01/2014 Authors: Finak G; Jiang W; Krouse K; Wei C; Sanz I; Phippard D; Asare A; De Rosa SC; Self S; Gottardo R
Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.
J Immunol Volume: 192 Page(s): 906 - 918
02/01/2014 Authors: Palanichamy A; Bauer JW; Yalavarthi S; Meednu N; Barnard J; Owen T; Cistrone C; Bird A; Rabinovich A; Nevarez S
Bone Marrow In Systemic Lupus Erythematosus Patients Contain a Highly Elevated Proportion Of Somatically Mutated, Activated Naive Cells Comprised Of Substantial Clonal Expansions
Volume: 65 Page(s): S1197 - S1197
10/01/2013 Authors: Hom J; Tipton C; Fucile C; Neary B; Wei C; Lee FE-H; Rosenberg A; Sanz I
Gene Expression Profiling Analysis Of Human B-Cell Subsets In Health and Systemic Lupus Erythematosus
Volume: 65 Page(s): S12 - S12
10/01/2013 Authors: Wei C; Ramos E; Allaire N; Szak S; Kalled S; Ranger A; Sanz I
Defining unique B cell signatures in patients with autoimmune blistering diseases
Volume: 133 Page(s): S46 - S46
05/01/2013 Authors: Feldman RJ; Wei C; Neary BE; Sanz I
Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion.
Clin Immunol Volume: 142 Page(s): 237 - 242
03/01/2012 Authors: Barr PM; Wei C; Roger J; Schaefer-Cutillo J; Kelly JL; Rosenberg AF; Jung J; Sanz I; Friedberg JW
Advances in human B cell phenotypic profiling.
Front Immunol Volume: 3 Page(s): 302
01/01/2012 Authors: Kaminski DA; Wei C; Qian Y; Rosenberg AF; Sanz I
Two major autoantibody clusters in systemic lupus erythematosus.
PLoS One Volume: 7 Page(s): e32001
01/01/2012 Authors: Ching KH; Burbelo PD; Tipton C; Wei C; Petri M; Sanz I; Iadarola MJ
Multiparameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus.
Methods Mol Biol Volume: 900 Page(s): 109 - 134
01/01/2012 Authors: Kaminski DA; Wei C; Rosenberg AF; Lee FE-H; Sanz I
OMIP-003: phenotypic analysis of human memory B cells.
Cytometry A Volume: 79 Page(s): 894 - 896
11/01/2011 Authors: Wei C; Jung J; Sanz I
Syk Inhibition with Fostamatinib Leads to Transitional B Lymphocyte Depletion
Volume: 63 Page(s): S684 - S685
10/01/2011 Authors: Wei C; Barr PM; Schaefer-Cutillo J; Jung J; Roger J; Kelly JL; Rosenberg A; Friedberg JW; Sanz I
The Comprehensive B Cell Profiling Analysis of a Multicenter SLE Cohort
Volume: 63 Page(s): S692 - S692
10/01/2011 Authors: Jung J; Biear J; Huang Y; Neary B; Marin E; Hossler J; Palmer E; Smith S; Akhter E; Sanford T
Plasmacytoid Dendritic Cells in Human Lupus Bone Marrow Are Primed for Interferon Alpha Production.
Volume: 63 Page(s): S979 - S980
10/01/2011 Authors: Nevarez S; Palanichamy A; Rabinovich A; Barnard J; Biear J; Panepento B; Wei C; Ritchlin C; Kobie J; Sanz I
B Cell Function and Cytokine Secretion After B Cell Depletion Therapy in SLE and Rheumatoid Arthritis
Volume: 63 Page(s): S683 - S683
10/01/2011 Authors: Palanichamy A; Roger J; Wang W; Barnard J; Biear J; Wei C; Sanz I; Anolik JH
Effect of Intravenous Cyclophosphamide Treatment on B Cells in SLE Nephritis
Volume: 63 Page(s): S977 - S977
10/01/2011 Authors: Wei C; Jung J; Marian V; Hardwick DF; Souto-Adeva G; Huang Y; Neary B; Illei GG; Sanz I
Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.
J Immunol Volume: 186 Page(s): 4640 - 4648
04/15/2011 Authors: Quch TD; Manjarrez-Orduo N; Adlowitz DG; Silver L; Yang H; Wei C; Milner ECB; Sanz I
Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.
Arthritis Res Ther Volume: 13 Page(s): R209
01/01/2011 Authors: Kobie JJ; Zheng B; Bryk P; Barnes M; Ritchlin CT; Tabechian DA; Anandarajah AP; Looney RJ; Thiele RG; Anolik JH
Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data.
Cytometry B Clin Cytom Volume: 78 Suppl 1 Page(s): S69 - S82
01/01/2010 Authors: Qian Y; Wei C; Eun-Hyung Lee F; Campbell J; Halliley J; Lee JA; Cai J; Kong YM; Sadat E; Thomson E
PHENOTYPIC AND FUNCTIONAL PROFILING OF HUMAN B CELLS
Volume: 76B Page(s): 412 - 412
01/01/2005 Authors: Sanz I; Wei C; Kobie J; Lee E-H; Scheurmann R
Novel human transitional B cell populations revealed by B cell depletion therapy.
J Immunol Volume: 182 Page(s): 5982 - 5993
05/15/2009 Authors: Palanichamy A; Barnard J; Zheng B; Owen T; Quach T; Wei C; Looney RJ; Sanz I; Anolik JH
Phenotypic and functional heterogeneity of human memory B cells.
Semin Immunol Volume: 20 Page(s): 67 - 82
02/01/2008 Authors: Sanz I; Wei C; Lee FE-H; Anolik J
A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus.
J Immunol Volume: 178 Page(s): 6624 - 6633
05/15/2007 Authors: Wei C; Anolik J; Cappione A; Zheng B; Pugh-Bernard A; Brooks J; Lee E-H; Milner ECB; Sanz I
CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells.
Blood Volume: 109 Page(s): 1611 - 1619
02/15/2007 Authors: Huggins J; Pellegrin T; Felgar RE; Wei C; Brown M; Zheng B; Milner ECB; Bernstein SH; Sanz I; Zand MS
A new population of CD27-Negative memory R cells lacking FcRH4 expression is expanded in SLE.
Volume: 54 Page(s): S567 - S567
09/01/2006 Authors: Zheng B; Owen T; Wei C; Barnard J; Lee E-H; Anolik J; Milner ECB; Sanz I
B cell reconstitution after rituximab recapitulates B cell ontogeny with a preponderance of transitional B cells and a paucity of memory B cells.
Volume: 54 Page(s): S776 - S776
09/01/2006 Authors: Anolik JH; Friedberg J; Barnard J; Owen T; Zheng B; Quach T; Wei C; Cushing E; Kelly J; Milner E
Definition of a novel population of CD27-negative human memory B-cells and its expansion in SLE.
Volume: 52 Page(s): S614 - S614
09/01/2005 Authors: Wei CW; Anolik J; Amedeo C; Huggins J; Zheng B; Milner E; Sanz I
Tumours can act as adjuvants for humoral immunity.
Immunology Volume: 102 Page(s): 486 - 497
04/01/2001 Authors: Brown DM; Fisher TL; Wei C; Frelinger JG; Lord EM
Generation and characterization of hK2 specific monoclonal antibodies using a novel tumor immunization strategy
FASEB JOURNAL Volume: 15 Page(s): A1208 - A1208
03/08/2001 Authors: Fisher TL; Brown D; Wei CW; Willis R; Lord E; Frelinger J
B cells in tumor bearing mice can produce anti-tumor antibodies and are potent antigen presenting cells
FASEB JOURNAL Volume: 15 Page(s): A661 - A661
03/07/2001 Authors: Brown DM; Fisher TL; Wei CW; Frelinger JG; Lord EM
Detection and quantification by homogeneous PCR of cell-free fetal DNA in maternal plasma.
Clin Chem Volume: 47 Page(s): 336 - 338
02/01/2001 Authors: Wei C; Saller DN; Sutherland JW
Reliable detection of extra-cellular fetal DNA in maternal blood.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 424 - 424
10/01/2000 Authors: Saller DN; Wei C; Sutherland JWH
Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes.
Int J Mol Med Volume: 2 Page(s): 487 - 496
10/01/1998 Authors: Wei C; Callahan BP; Turner MJ; Willis RA; Lord EM; Barth RK; Frelinger JG
A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer (Review).
Int J Mol Med Volume: 1 Page(s): 379 - 386
02/01/1998 Authors: Willis RA; Wei C; Turner MJ; Callahan BP; Pugh AE; Barth RK; Lord EM; Frelinger JG
Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.
Proc Natl Acad Sci U S A Volume: 94 Page(s): 6369 - 6374
06/10/1997 Authors: Wei C; Willis RA; Tilton BR; Looney RJ; Lord EM; Barth RK; Frelinger JG
Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes.
Cancer Immunol Immunother Volume: 42 Page(s): 362 - 368
07/01/1996 Authors: Wei C; Storozynsky E; McAdam AJ; Yeh KY; Tilton BR; Willis RA; Barth RK; Looney RJ; Lord EM; Frelinger JG
p23rab2, a ras-like GTPase with a -GGGCC C-terminus, is isoprenylated but not detectably carboxymethylated in NIH3T3 cells.
Oncogene Volume: 7 Page(s): 467 - 473
03/01/1992 Authors: Wei C; Lutz R; Sinensky M; Macara IG
Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts.
Biochem J Volume: 272 Page(s): 569 - 575
12/15/1990 Authors: Stathopoulos VM; Coco-Maroney A; Wei CW; Goth M; Zaricznyj C; Macara IG
Specific desensitization of the epidermal growth factor receptor by pp60v-src.
J Cell Biochem Volume: 40 Page(s): 271 - 278
07/01/1989 Authors: Gray GM; Wei CN; Macara IG

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