Publications

• N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
  PLoS Genet Volume: 12 Page(s): e1006083
  05/01/2016 Authors: Liu X; Wang C-E; Hong Y; Zhao T; Wang G; Gaertig MA; Sun M; Li S; Li X-J
• Paternal duplication of the 11p15 centromeric imprinting control region is associated with increased expression of CDKN1C in a child with Russell-Silver syndrome.
  Am J Med Genet A Volume: 167A Page(s): 3229 - 3233
  12/01/2015 Authors: Xue Y; Shankar S; Cornell K; Dai Z; Wang C-E; Rudd MK; Coffee B
• Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.
  Mol Neurodegener Volume: 10 Page(s): 42
  09/03/2015 Authors: Wang G; Yang H; Yan S; Wang C-E; Liu X; Zhao B; Ouyang Z; Yin P; Liu Z; Zhao Y
• Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
  J Neurosci Volume: 35 Page(s): 8345 - 8358
  05/27/2015 Authors: Yang W; Wang G; Wang C-E; Guo X; Yin P; Gao J; Tu Z; Wang Z; Wu J; Hu X
• Early Parkinson's disease symptoms in -synuclein transgenic monkeys.
  Hum Mol Genet Volume: 24 Page(s): 2308 - 2317
  04/15/2015 Authors: Niu Y; Guo X; Chen Y; Wang C-E; Gao J; Yang W; Kang Y; Si W; Wang H; Yang S-H
• Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.
  J Neurosci Volume: 34 Page(s): 8411 - 8422
  06/18/2014 Authors: Wade BE; Wang C-E; Yan S; Bhat K; Huang B; Li S; Li X-J
• TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.
  Hum Mol Genet Volume: 23 Page(s): 2678 - 2693
  05/15/2014 Authors: Yan S; Wang C-E; Wei W; Gaertig MA; Lai L; Li S; Li X-J
• Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): 5706 - 5711
  04/15/2014 Authors: Bhat KP; Yan S; Wang C-E; Li S; Li X-J
• Species-dependent neuropathology in transgenic SOD1 pigs.
  Cell Res Volume: 24 Page(s): 464 - 481
  04/01/2014 Authors: Yang H; Wang G; Sun H; Shu R; Liu T; Wang C-E; Liu Z; Zhao Y; Zhao B; Ouyang Z
• Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.
  J Cell Biol Volume: 202 Page(s): 1123 - 1138
  09/30/2013 Authors: Xu Q; Huang S; Song M; Wang C-E; Yan S; Liu X; Gaertig MA; Yu SP; Li H; Li S
• Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
  J Neurosci Volume: 33 Page(s): 8172 - 8184
  05/08/2013 Authors: Weng L; Lin Y-F; Li AL; Wang C-E; Yan S; Sun M; Gaertig MA; Mitha N; Kosaka J; Wakabayashi T
• Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma.
  Oncogene Volume: 32 Page(s): 713 - 723
  02/07/2013 Authors: Liu J; Cheng X; Zhang Y; Li S; Cui H; Zhang L; Shi R; Zhao Z; He C; Wang C
• Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic -cells.
  Cell Mol Life Sci Volume: 69 Page(s): 1305 - 1317
  04/01/2012 Authors: Cape A; Chen X; Wang C-E; O'Neill A; Lin Y-F; He J; Xu X-S; Yi H; Li H; Li S
• Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.
  Hum Mol Genet Volume: 20 Page(s): 1424 - 1437
  04/01/2011 Authors: Havel LS; Wang C-E; Wade B; Huang B; Li S; Li X-J
• Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.
  Mol Brain Volume: 3 Page(s): 33
  11/02/2010 Authors: Wang C-E; Li S; Li X-J
• Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs.
  Hum Mol Genet Volume: 19 Page(s): 3983 - 3994
  10/15/2010 Authors: Yang D; Wang C-E; Zhao B; Li W; Ouyang Z; Liu Z; Yang H; Fan P; O'Neill A; Gu W
• Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
  Hum Mol Genet Volume: 19 Page(s): 2445 - 2455
  06/15/2010 Authors: Li X; Wang C-E; Huang S; Xu X; Li X-J; Li H; Li S
• Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
  J Biol Chem Volume: 285 Page(s): 10653 - 10661
  04/02/2010 Authors: Bradford J; Shin J-Y; Roberts M; Wang C-E; Sheng G; Li S; Li X-J
• Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.
  Proc Natl Acad Sci U S A Volume: 106 Page(s): 22480 - 22485
  12/29/2009 Authors: Bradford J; Shin J-Y; Roberts M; Wang C-E; Li X-J; Li S
• Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.
  J Neurosci Volume: 28 Page(s): 13285 - 13295
  12/03/2008 Authors: Tydlacka S; Wang C-E; Wang X; Li S; Li X-J
• Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
  Hum Mol Genet Volume: 17 Page(s): 2738 - 2751
  09/01/2008 Authors: Wang C-E; Tydlacka S; Orr AL; Yang S-H; Graham RK; Hayden MR; Li S; Chan AWS; Li X-J
• Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice.
  J Clin Invest Volume: 118 Page(s): 2785 - 2795
  08/01/2008 Authors: Sheng G; Xu X; Lin Y-F; Wang C-E; Rong J; Cheng D; Peng J; Jiang X; Li S-H; Li X-J
• Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin.
  J Cell Biol Volume: 181 Page(s): 803 - 816
  06/02/2008 Authors: Wang C-E; Zhou H; McGuire JR; Cerullo V; Lee B; Li S-H; Li X-J
• Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity.
  J Biol Chem Volume: 283 Page(s): 8283 - 8290
  03/28/2008 Authors: Friedman MJ; Wang C-E; Li X-J; Li S
• Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.
  J Cell Biol Volume: 180 Page(s): 1177 - 1189
  03/24/2008 Authors: Wang J; Wang C-E; Orr A; Tydlacka S; Li S-H; Li X-J
• N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
  J Neurosci Volume: 28 Page(s): 2783 - 2792
  03/12/2008 Authors: Orr AL; Li S; Wang C-E; Li H; Wang J; Rong J; Xu X; Mastroberardino PG; Greenamyre JT; Li X-J
• Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity.
  J Cell Biol Volume: 171 Page(s): 1001 - 1012
  12/19/2005 Authors: Shin J-Y; Fang Z-H; Yu Z-X; Wang C-E; Li S-H; Li X-J
• Polyglutamine expansion of huntingtin impairs its nuclear export.
  Nat Genet Volume: 37 Page(s): 198 - 204
  02/01/2005 Authors: Cornett J; Cao F; Wang C-E; Ross CA; Bates GP; Li S-H; Li X-J
• Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development.
  Brain Res Dev Brain Res Volume: 149 Page(s): 63 - 71
  03/22/2004 Authors: Tissir F; Wang C-E; Goffinet AM
• [Effect of supplemented danggui shaoyao powder and its disassembled prescriptions on lymphocytes proliferation in aged rats].
  Zhongguo Zhong Xi Yi Jie He Za Zhi Volume: 23 Page(s): 841 - 844
  11/01/2003 Authors: He H-W; Wang C-E; Xie Y