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Profile

Charles Searles Jr MD

  • Department of Medicine
    Professor
  • (404) 727-3754
  • csearle@emory.edu
Head shot of Charles Searles Jr

Overview

Dr. Searles received his B.A. from Princeton University and M.D. from Georgetown University. He did his internal medicine residency and cardiology fellowship at Emory University School of Medicine. After fellowship, he joined Emory's Division of Cardiology faculty, where he is an Assistant Professor of Medicine. Since 2004, Dr. Searles has been Associate Director of the Emory Cardiology Fellowship Program. He also directs the Basic Science Investigator Pathway for the fellowship program.

His laboratory has been focused on molecular mechanisms by which different physiologic and pathophysiologic stimuli modulate vascular gene expression, with particular emphasis on posttranscriptional regulation of gene expression in endothelial cells. They have spent considerable time examining how gene expression in endothelial cells is influenced by shear stress, the mechanical forces associated with blood flow. In vivo, these forces play a critical role in the regulation of vascular tone, vascular remodeling, and the development of atherosclerotic lesions. His group was among the first to report that shear stress forces enhance the expression of a distinct group of microRNAs in endothelial cells, and they are performing studies to show that microRNAs are key regulators of anti- and pro-atherogenic phenotypes of endothelial cells. The recent recognition of extracellular microRNAs as potential cell-to-cell communication molecules and biomarkers for disease has led to a new and exciting direction of research in his lab, and his group is now devoting significant effort to studying the export and uptake of microRNAs by endothelial and other vascular cells. This work has involved studies of extracellular microRNAs in cultured cells and the blood of mice and humans. They are very excited that this work has led to new intra- and interinstitutional collaborations between his group and others.

His group has also been part of large, collaborative effort between Emory and Georgia Tech to develop nanotechnologies for the analysis and detection of atherosclerotic plaque formation. Currently, their work on this project focuses on the development of nucleic acid probes, known as molecular beacons, for the detection and quantification of microRNAs.

Dr. Searles is a staff Cardiologist at the Atlanta VA Medical center where he is Director of the CCU. He also attends in the cardiac catheterization and echocardiography laboratories, and he supervises fellows on cath and echo rotations.

Academic Appointment

  • Distinguished Physician, Emory University School of Medicine
  • Associate Professor of Medicine, Department of Medicine, Emory University School of Medicine

Education

Degrees

  • MD from Georgetown University School of Medicine
  • BA from Princeton University

Research

Focus

  • My laboratory has been interested in regulation of gene expression in endothelial cells (ECs). In vivo, ECs are subjected to both hemodynamic and biochemical stimuli, which lead to changes in EC gene expression and function. We have focused on regulatory mechanisms responsible for these changes. Currently, my group is investigating the role of microRNAs in the EC response to blood flow. We are also performing studies to examine the role of extracellular microRNAs as biomarkers for cardiovascular disease.

Publications

  • Association between electronic cigarette use and cardiovascular disease among a United States representative population.
    Int J Cardiol Cardiovasc Risk Prev Volume: 25 Page(s): 200401
    06/01/2025 Authors: Naqvi H; Searles C
  • MicroRNAs and Cardiovascular Disease Risk.
    Curr Cardiol Rep Volume: 26 Page(s): 51 - 60
    02/01/2024 Authors: Searles CD
  • Metabolomic signatures of ideal cardiovascular health in black adults.
    Sci Rep Volume: 14 Page(s): 1794
    01/20/2024 Authors: Islam SJ; Liu C; Mohandas AN; Rooney K; Nayak A; Mehta A; Ko Y-A; Kim JH; Sun YV; Dunbar SB
  • Shedding Light on the Roles of Ceramide in Human Microvascular Function.
    Circ Res Volume: 134 Page(s): 97 - 99
    01/05/2024 Authors: Searles CD
  • Generating a Buzz About a New Treatment for Right Ventricular Failure.
    JACC Basic Transl Sci Volume: 8 Page(s): 298 - 300
    03/01/2023 Authors: Searles CD
  • The US Department of Veterans Affairs Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD): A Biorepository Addressing National Health Threats.
    Open Forum Infect Dis Volume: 9 Page(s): ofac641
    12/01/2022 Authors: Harley JB; Pyarajan S; Partan ES; Epstein L; Wertheim JA; Diwan A; Woods CW; Davey V; Blair S; Clark DH
  • Association of physical activity with arterial stiffness among Black adults.
    Vasc Med Volume: 27 Page(s): 13 - 20
    02/01/2022 Authors: Islam SJ; Beydoun N; Mehta A; Kim JH; Ko Y-A; Jin Q; Baltrus P; Topel ML; Liu C; Mujahid MS
  • Neighborhood characteristics and ideal cardiovascular health among Black adults: results from the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity.
    Ann Epidemiol Volume: 65 Page(s): 120.e1 - 120.e10
    01/01/2022 Authors: Islam SJ; Kim JH; Baltrus P; Topel ML; Liu C; Ko Y-A; Mujahid MS; Vaccarino V; Sims M; Mubasher M
  • Association Between Early Trauma and Ideal Cardiovascular Health Among Black Americans: Results From the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity.
    Circ Cardiovasc Qual Outcomes Volume: 14 Page(s): e007904
    09/01/2021 Authors: Islam SJ; Hwan Kim J; Joseph E; Topel M; Baltrus P; Liu C; Ko Y-A; Almuwaqqat Z; Mujahid MS; Sims M
  • Experience With Cardiology-Oriented Outcomes in Critically Ill Patients With Coronavirus Disease 2019.
    Crit Care Explor Volume: 2 Page(s): e0288
    12/01/2020 Authors: Connor-Schuler R; Wong AI; Shah A; Fiza B; Lyle M; Ramonell R; Hockstein M; Chang G; Markham D; Searles C
  • Physical Activity and Arterial Stiffness in Black Adults
    Volume: 142
    11/17/2020 Authors: Islam S; Beydoun N; Mehta A; Kim JH; Ko Y-A; Jin Q; Baltrus P; Topel ML; Liu C; Vaccarino V
  • Development of MicroRNA-Based Therapeutics for Vascular Disease.
    Circ Res Volume: 127 Page(s): 1179 - 1181
    10/09/2020 Authors: Jones KJ; Searles CD
  • Individual Psychosocial Resilience, Neighborhood Context, and Cardiovascular Health in Black Adults: A Multilevel Investigation From the Morehouse-Emory Cardiovascular Center for Health Equity Study.
    Circ Cardiovasc Qual Outcomes Volume: 13 Page(s): e006638
    10/01/2020 Authors: Kim JH; Islam SJ; Topel ML; Ko Y-A; Mujahid MS; Vaccarino V; Liu C; Sims M; Mubasher M; Searles CD
  • Cardiovascular Risk and Resilience Among Black Adults: Rationale and Design of the MECA Study.
    J Am Heart Assoc Volume: 9 Page(s): e015247
    05/05/2020 Authors: Islam SJ; Kim JH; Topel M; Liu C; Ko Y-A; Mujahid MS; Sims M; Mubasher M; Ejaz K; Morgan-Billingslea J
  • Plasma Processing IsCritical When Measuring miRNA inPlasma.
    JACC Clin Electrophysiol Volume: 6 Page(s): 244
    02/01/2020 Authors: Mitchell AJ; Searles CD
  • Mir-155 is a Negative Regulator of Acute Oscillatory Shear Stress-induced AT1R/ETS-1 Pathway and Downstream Vascular Inflammation and Barrier Dysfunction
    Volume: 39
    05/01/2019 Authors: Mohamed I; Thomas S; Rooney K; Willett N; Taylor WR; Searles C
  • Neighborhood and Individual Resilience in Cardiovascular Health of Blacks: A Multi-Level Investigation From Morehouse-Emory Cardiovascular (MECA) Center for Health Equity
    Volume: 138
    11/06/2018 Authors: Kim JH; Topel M; Baltrus P; Pemu P; Ko Y-A; Lewis T; Vaccarino V; Liu C; Mubasher M; Searles C
  • Mir-155 Mitigates Acute Oscillatory Shear Stress (OSS)-Induced Vascular Inflammation and Barrier Dysfunction Through Down Regulation of the AT1R-ETS1 Pathway
    Volume: 37
    05/01/2017 Authors: Mohamed I; Thomas S; Sutliff R; Willet N; Searles C
  • MicroRNA Detection Using a Double Molecular Beacon Approach: Distinguishing Between miRNA and Pre-miRNA.
    Theranostics Volume: 7 Page(s): 634 - 646
    01/01/2017 Authors: James AM; Baker MB; Bao G; Searles CD
  • Racial Differences in Circulating miRNA and Metabolomic Profiles of Participants in the Morehouse and Emory Team Up to Eliminate Health Disparities Study
    Volume: 134
    11/11/2016 Authors: James AM; Uppal K; Thomas S; Rooney K; Ko Y-A; Taylor HA; Quyyumi AA; Jones DP; Searles CD
  • Platelets confound the measurement of extracellular miRNA in archived plasma.
    Sci Rep Volume: 6 Page(s): 32651
    09/13/2016 Authors: Mitchell AJ; Gray WD; Hayek SS; Ko Y-A; Thomas S; Rooney K; Awad M; Roback JD; Quyyumi A; Searles CD
  • Dysregulation of miR-155 in Acute Oscillatory Shear Stress (OSS)-mediated Oxidative Stress, Inflammation and Endothelial Dysfunction
    Volume: 36
    05/01/2016 Authors: Mohamed I; Thomas S; Rooney K; Sutliff R; Willett N; Searles C
  • Rheumatoid Arthritis Presenting as Acute Myopericarditis.
    Am J Med Volume: 129 Page(s): e17 - e18
    05/01/2016 Authors: Mitchell AJ; Alexy T; Rubinsztain L; Iqbal A; Shah AJ; Zafari AM; Searles CD
  • TOWARDS A METABOLIC-MIRNA SIGNATURE OF VULNERABLE CORONARY ARTERY DISEASE: THE AIR FORCE HEALTH STUDY
    Volume: 67 Page(s): 596 - 596
    04/05/2016 Authors: Mitchell A; Walker D; Ko Y-A; Shah A; Quyyumi A; Jones D; Searles C
  • CIRCULATING EXTRACELLULAR MIRNA ASSOCIATED WITH PERIPHERAL ARTERIAL DISEASE
    Volume: 67 Page(s): 2281 - 2281
    04/05/2016 Authors: Mitchell A; Hayek S; Gray W; Thomas S; Kim R; Quyyumi A; Searles C
  • TNF-alpha Alters Intra- and Extracellular isomiR Profiles of Endothelial Cells
    Volume: 30
    04/01/2016 Authors: Dyalishvili M; James AM; Rooney K; Searles CD
  • Circulating microRNA and isomiR Profiles in Patients with Varying CVD Severity: Using isomiRs as Potential Biomarkers and Therapeutic Targets
    Volume: 30
    04/01/2016 Authors: James AM; Thomas S; Rooney K; Searles CD
  • Peroxisome Proliferator-Activated Receptor and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling.
    Am J Respir Cell Mol Biol Volume: 54 Page(s): 136 - 146
    01/01/2016 Authors: Kang B-Y; Park KK; Kleinhenz JM; Murphy TC; Green DE; Bijli KM; Yeligar SM; Carthan KA; Searles CD; Sutliff RL
  • Pleomorphic Structures in Human Blood Are Red Blood Cell-Derived Microparticles, Not Bacteria.
    PLoS One Volume: 11 Page(s): e0163582
    01/01/2016 Authors: Mitchell AJ; Gray WD; Schroeder M; Yi H; Taylor JV; Dillard RS; Ke Z; Wright ER; Stephens D; Roback JD
  • Circulating microparticles exhibit multiple discrete changes in annexin V binding and calcein-AM cleavage in cardiovascular disease
    FASEB JOURNAL Volume: 29
    04/01/2015 Authors: Gray W; Mitchell A; Searles C
  • Seven Encapsulated and Nonencapsulated (iso)microRNAs in Human Samples Predict Coronary Atherosclerosis and Cardiac Events
    Volume: 29
    04/01/2015 Authors: James AM; Thomas S; Rooney K; Quyyumi A; Wu H; Johnson Z; Searles C
  • PPAR GAMMA LIGANDS ATTENUATE HYPOXIA-INDUCED PROLIFERATION IN VASCULAR SMOOTH MUSCLE CELLS THROUGH MODULATION OF MIRNA-21
    Volume: 63 Page(s): 449 - 450
    02/01/2015 Authors: Green DE; Murphy T; Kang B; Searles C; Hart CM
  • Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology.
    Circ Res Volume: 116 Page(s): 255 - 263
    01/16/2015 Authors: Gray WD; French KM; Ghosh-Choudhary S; Maxwell JT; Brown ME; Platt MO; Searles CD; Davis ME
  • Ppar gamma Ligands Attenuate Hypoxia-Induced Proliferation In Vascular Smooth Muscle Cells Through Modulation Of Mirna-21
    Volume: 191
    01/01/2015 Authors: Green DE; Murphy TC; Kang BY; Searles CD; Hart CM
  • An accurate, precise method for general labeling of extracellular vesicles.
    MethodsX Volume: 2 Page(s): 360 - 367
    01/01/2015 Authors: Gray WD; Mitchell AJ; Searles CD
  • PPAR Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21.
    PLoS One Volume: 10 Page(s): e0133391
    01/01/2015 Authors: Green DE; Murphy TC; Kang B-Y; Searles CD; Hart CM
  • Circulating miR-146a Shows Positive Correlation with Arterial Stiffness and Negative Correlation with Aerobic Exercise Capacity Among Healthy Adults
    Volume: 130
    11/25/2014 Authors: Rezvan A; Rooney K; Al Mheid L; Ghasemzadeh N; Jo H; Quyyumi AA; Searles CD
  • TNF- alters the release and transfer of microparticle-encapsulated miRNAs from endothelial cells.
    Physiol Genomics Volume: 46 Page(s): 833 - 840
    11/15/2014 Authors: Alexy T; Rooney K; Weber M; Gray WD; Searles CD
  • MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells.
    Am J Physiol Heart Circ Physiol Volume: 306 Page(s): H1192 - H1203
    04/15/2014 Authors: Weber M; Kim S; Patterson N; Rooney K; Searles CD
  • TNF-alpha alters the release and transfer of miRNAs from endothelial cells
    Volume: 28
    04/01/2014 Authors: Alexy T; Rooney K; Weber M; Searles C
  • miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.
    Am J Physiol Cell Physiol Volume: 306 Page(s): C551 - C558
    03/15/2014 Authors: Hudson MB; Woodworth-Hobbs ME; Zheng B; Rahnert JA; Blount MA; Gooch JL; Searles CD; Price SR
  • Shear sensitive microRNAs and atherosclerosis.
    Biorheology Volume: 51 Page(s): 147 - 158
    01/01/2014 Authors: Alexy T; James AM; Searles CD
  • Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.
    FEBS Lett Volume: 587 Page(s): 3456 - 3463
    11/01/2013 Authors: Finn NA; Eapen D; Manocha P; Al Kassem H; Lassegue B; Ghasemzadeh N; Quyyumi A; Searles CD
  • Using information theory to assess the communicative capacity of circulating microRNA.
    Biochem Biophys Res Commun Volume: 440 Page(s): 1 - 7
    10/11/2013 Authors: Finn NA; Searles CD
  • Rat Ckit plus Cardiac Progenitor Cells Release Pro-survival Micrornas In Exosomes Following Hypoxic Stimulation.
    Volume: 113
    08/01/2013 Authors: Gray WD; Finn N; Searles C; Davis ME
  • miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells.
    Atherosclerosis Volume: 228 Page(s): 168 - 174
    05/01/2013 Authors: Remus EW; Lyle AN; Weiss D; Landzuri N; Weber M; Searles C; Taylor WR
  • Hypoxia mediates mutual repression between microRNA-27a and PPAR in the pulmonary vasculature.
    PLoS One Volume: 8 Page(s): e79503
    01/01/2013 Authors: Kang B-Y; Park KK; Green DE; Bijli KM; Searles CD; Sutliff RL; Hart CM
  • The use of molecular beacons to detect and quantify microRNA.
    Methods Mol Biol Volume: 1039 Page(s): 279 - 287
    01/01/2013 Authors: Baker MB; Bao G; Searles CD
  • Intracellular and Extracellular miRNAs in Regulation of Angiogenesis Signaling.
    Curr Angiogenes Volume: 4 Page(s): 299 - 307
    12/01/2012 Authors: Finn NA; Searles CD
  • Circulating miRNA Transport Modality is Altered in Subjects with CHD with Implications for Endothelial Cell microRNA Uptake
    CIRCULATION Volume: 126
    11/20/2012 Authors: Finn NA; Eapen D; Manocha P; Quyyumi A; Searles CD
  • Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.
    J Card Fail Volume: 18 Page(s): 717 - 723
    09/01/2012 Authors: Blanco RR; Austin H; Vest RN; Valadri R; Li W; Lassegue B; Song Q; London B; Dudley SC; Bloom HL
  • Shear-responsive miR-155 Regulates Endothelial Cell Phenotype and Function
    Volume: 26
    04/01/2012 Authors: Weber M; Kim S; Patterson N; Searles CD
  • Overexpression of mir181a protects against Ang II induced osteopontin expression in VSMC
    Volume: 26
    04/01/2012 Authors: Remus ERW; Lyle A; Weber M; Searles CD; Taylor R
  • In vitro quantification of specific microRNA using molecular beacons.
    Nucleic Acids Res Volume: 40 Page(s): e13
    01/01/2012 Authors: Baker MB; Bao G; Searles CD
  • MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB.
    Cardiol Res Pract Volume: 2011 Page(s): 532915
    01/01/2011 Authors: Weber M; Baker MB; Patel RS; Quyyumi AA; Bao G; Searles CD
  • Modulation of EC Function by miR-155, a Shear Stress-Responsive miRNA
    CIRCULATION Volume: 122
    11/23/2010 Authors: Weber M; Searles CD
  • MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity.
    Biochem Biophys Res Commun Volume: 393 Page(s): 643 - 648
    03/19/2010 Authors: Weber M; Baker MB; Moore JP; Searles CD
  • Laminar shear stress modulates phosphorylation and localization of RNA polymerase II on the endothelial nitric oxide synthase gene.
    Arterioscler Thromb Vasc Biol Volume: 30 Page(s): 561 - 567
    03/01/2010 Authors: Moore JP; Weber M; Searles CD
  • Nebivolol in high-risk, obese African Americans with stage 1 hypertension: effects on blood pressure, vascular compliance, and endothelial function.
    J Clin Hypertens (Greenwich) Volume: 11 Page(s): 720 - 725
    12/01/2009 Authors: Merchant N; Searles CD; Pandian A; Rahman ST; Ferdinand KC; Umpierrez GE; Khan BV
  • Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA.
    Am J Physiol Cell Physiol Volume: 296 Page(s): C498 - C504
    03/01/2009 Authors: Jones R; Baker MB; Weber M; Harrison DG; Bao G; Searles CD
  • Endothelial Cell MicroRNA Expression in Response to Laminar Shear Stress
    Volume: 118 Page(s): S298 - S298
    10/28/2008 Authors: Searles CD; Moore J; Baker M; Weber M
  • Statins upregulate endothelial nitric oxide synthase via a cofilin-dependent pathway
    Volume: 28 Page(s): E141 - E142
    06/01/2008 Authors: Kosmidou I; Moore JP; Weber M; Searles CD
  • Statin treatment and 3' polyadenylation of eNOS mRNA.
    Arterioscler Thromb Vasc Biol Volume: 27 Page(s): 2642 - 2649
    12/01/2007 Authors: Kosmidou I; Moore JP; Weber M; Searles CD
  • Laminar shear stress enhances the activity and localization of RNA polymerase II on the eNOS gene
    Volume: 116 Page(s): 30 - 31
    10/16/2007 Authors: Weber M; Moore JP; Searles CD
  • Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression.
    Am J Physiol Cell Physiol Volume: 291 Page(s): C803 - C816
    11/01/2006 Authors: Searles CD
  • Statins modulate eNOS mRNA processing
    Volume: 114 Page(s): 152 - 152
    10/31/2006 Authors: Kosmidou I; Weber M; Searles CD
  • Endothelial mechanotransduction, nitric oxide and vascular inflammation.
    J Intern Med Volume: 259 Page(s): 351 - 363
    04/01/2006 Authors: Harrison DG; Widder J; Grumbach I; Chen W; Weber M; Searles C
  • Requirement of downstream sequence for eNOS mRNA 3 ' cleavage and polyadenylation
    Volume: 112 Page(s): U79 - U79
    10/25/2005 Authors: Weber M; Harrison DG; Searles CD
  • Laminar shear stress and 3' polyadenylation of eNOS mRNA.
    Circ Res Volume: 96 Page(s): 1161 - 1168
    06/10/2005 Authors: Weber M; Hagedorn CH; Harrison DG; Searles CD
  • Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.
    Circ Res Volume: 95 Page(s): 488 - 495
    09/03/2004 Authors: Searles CD; Ide L; Davis ME; Cai H; Weber M
  • Post-transcriptional regulation of endothelial nitric oxide synthase during cell growth: Evidence for the role beta-actin
    FASEB JOURNAL Volume: 16 Page(s): A440 - A440
    03/20/2002 Authors: Searles CD; Ide L; Davis ME; Harrison DG
  • The nitric oxide pathway and oxidative stress in heart failure.
    Congest Heart Fail Volume: 8 Page(s): 142 - 155
    01/01/2002 Authors: Searles CD
  • The interaction of nitric oxide, bradykinin, and the angiotensin II type 2 receptor: lessons learned from transgenic mice.
    J Clin Invest Volume: 104 Page(s): 1013 - 1014
    10/01/1999 Authors: Searles CD; Harrison DG
  • Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.
    Circ Res Volume: 85 Page(s): 588 - 595
    10/01/1999 Authors: Searles CD; Miwa Y; Harrison DG; Ramasamy S
  • Post-transcriptional regulation of the endothelial cell nitric oxide synthase
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 27 Page(s): S76 - S76
    01/01/1999 Authors: Harrison DG; Searles CD; Ramasamy S; Miwa Y
  • Role of the 3' untranslated region in regulation of endothelial nitric oxide synthase gene expression.
    CIRCULATION Volume: 96 Page(s): 259 - 259
    10/21/1997 Authors: Searles CD; Miwa Y; Harrison DG; Ramasamy S
  • Post transcriptional regulation of endothelial nitric oxide synthase gene expression during cell growth
    CIRCULATION Volume: 94 Page(s): 891 - 891
    10/15/1996 Authors: Searles CD; Harrison DG; Ramasamy S
  • The effect of aluminum on markers for synaptic neurotransmission, cyclic AMP, and neurofilaments in a neuroblastoma x glioma hybridoma (NG108-15).
    Brain Res Volume: 528 Page(s): 73 - 79
    09/24/1990 Authors: Singer HS; Searles CD; Hahn IH; March JL; Troncoso JC
  • Effects of anticonvulsants on cholinergic and GABAergic properties in the neuronal cell clone NG108-15.
    Neurochem Res Volume: 13 Page(s): 1007 - 1013
    10/01/1988 Authors: Searles CD; Slesinger PA; Singer HS
  • MECHANISMS FOR RETARDATION IN CHROMOSOMAL DISORDERS
    ANNALS OF NEUROLOGY Volume: 24 Page(s): 338 - 339
    08/01/1988 Authors: SINGER HS; SEARLES C; OSTERGRANITE ML; COYLE J
  • The identification and characterization of a GABAergic system in the cholinergic neuroblastoma x glioma hybrid clone NG108-15.
    Brain Res Volume: 448 Page(s): 373 - 376
    05/17/1988 Authors: Searles CD; Singer HS
  • DIFFERENTIAL EFFECT OF ANTICONVULSANTS ON CHOLINERGIC AND GABAERGIC ACTIVITY IN A NEURONAL CELL CLONE
    EPILEPSIA Volume: 28 Page(s): 602 - 602
    09/01/1987 Authors: SINGER HS; SEARLES C; SLESINGER P
  • PRINCIPLES OF SYNAPTIC NEUROCHEMICAL DEVELOPMENT AS DEMONSTRATED BY AN AUTORADIOGRAPHIC ANALYSIS OF PRESYNAPTIC AND POSTSYNAPTIC CHOLINERGIC BINDING
    ANNALS OF NEUROLOGY Volume: 22 Page(s): 433 - 433
    09/01/1987 Authors: SINGER HS; SEARLES C; SLESINGER P; COYLE JT
  • THE EFFECT OF ANTICONVULSANTS ON GABAERGIC ACTIVITY IN A NEURONAL CELL CLONE
    ANNALS OF NEUROLOGY Volume: 22 Page(s): 433 - 433
    09/01/1987 Authors: SINGER HS; SEARLES C
  • Effect of anticonvulsants on the neuroblastoma x glioma hybrid cell line NG108-15.
    Prog Clin Biol Res Volume: 253 Page(s): 339 - 347
    01/01/1987 Authors: Singer HS; Searles C; Slesinger P
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