Charles Searles Jr MD
Overview
Dr. Searles received his B.A. from Princeton University and M.D. from Georgetown University. He did his internal medicine residency and cardiology fellowship at Emory University School of Medicine. After fellowship, he joined Emory's Division of Cardiology faculty, where he is an Assistant Professor of Medicine. Since 2004, Dr. Searles has been Associate Director of the Emory Cardiology Fellowship Program. He also directs the Basic Science Investigator Pathway for the fellowship program.
His laboratory has been focused on molecular mechanisms by which different physiologic and pathophysiologic stimuli modulate vascular gene expression, with particular emphasis on posttranscriptional regulation of gene expression in endothelial cells. They have spent considerable time examining how gene expression in endothelial cells is influenced by shear stress, the mechanical forces associated with blood flow. In vivo, these forces play a critical role in the regulation of vascular tone, vascular remodeling, and the development of atherosclerotic lesions. His group was among the first to report that shear stress forces enhance the expression of a distinct group of microRNAs in endothelial cells, and they are performing studies to show that microRNAs are key regulators of anti- and pro-atherogenic phenotypes of endothelial cells. The recent recognition of extracellular microRNAs as potential cell-to-cell communication molecules and biomarkers for disease has led to a new and exciting direction of research in his lab, and his group is now devoting significant effort to studying the export and uptake of microRNAs by endothelial and other vascular cells. This work has involved studies of extracellular microRNAs in cultured cells and the blood of mice and humans. They are very excited that this work has led to new intra- and interinstitutional collaborations between his group and others.
His group has also been part of large, collaborative effort between Emory and Georgia Tech to develop nanotechnologies for the analysis and detection of atherosclerotic plaque formation. Currently, their work on this project focuses on the development of nucleic acid probes, known as molecular beacons, for the detection and quantification of microRNAs.
Dr. Searles is a staff Cardiologist at the Atlanta VA Medical center where he is Director of the CCU. He also attends in the cardiac catheterization and echocardiography laboratories, and he supervises fellows on cath and echo rotations.
Academic Appointment
- Distinguished Physician, Emory University School of Medicine
- Associate Professor of Medicine, Department of Medicine, Emory University School of Medicine
Education
Degrees
- MD from Georgetown University School of Medicine
- BA from Princeton University
Research
Focus
- My laboratory has been interested in regulation of gene expression in endothelial cells (ECs). In vivo, ECs are subjected to both hemodynamic and biochemical stimuli, which lead to changes in EC gene expression and function. We have focused on regulatory mechanisms responsible for these changes. Currently, my group is investigating the role of microRNAs in the EC response to blood flow. We are also performing studies to examine the role of extracellular microRNAs as biomarkers for cardiovascular disease.
Publications
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Association between electronic cigarette use and cardiovascular disease among a United States representative population.
Int J Cardiol Cardiovasc Risk Prev Volume: 25 Page(s): 200401
06/01/2025 Authors: Naqvi H; Searles C -
MicroRNAs and Cardiovascular Disease Risk.
Curr Cardiol Rep Volume: 26 Page(s): 51 - 60
02/01/2024 Authors: Searles CD -
Metabolomic signatures of ideal cardiovascular health in black adults.
Sci Rep Volume: 14 Page(s): 1794
01/20/2024 Authors: Islam SJ; Liu C; Mohandas AN; Rooney K; Nayak A; Mehta A; Ko Y-A; Kim JH; Sun YV; Dunbar SB -
Shedding Light on the Roles of Ceramide in Human Microvascular Function.
Circ Res Volume: 134 Page(s): 97 - 99
01/05/2024 Authors: Searles CD -
Generating a Buzz About a New Treatment for Right Ventricular Failure.
JACC Basic Transl Sci Volume: 8 Page(s): 298 - 300
03/01/2023 Authors: Searles CD -
The US Department of Veterans Affairs Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD): A Biorepository Addressing National Health Threats.
Open Forum Infect Dis Volume: 9 Page(s): ofac641
12/01/2022 Authors: Harley JB; Pyarajan S; Partan ES; Epstein L; Wertheim JA; Diwan A; Woods CW; Davey V; Blair S; Clark DH -
Association of physical activity with arterial stiffness among Black adults.
Vasc Med Volume: 27 Page(s): 13 - 20
02/01/2022 Authors: Islam SJ; Beydoun N; Mehta A; Kim JH; Ko Y-A; Jin Q; Baltrus P; Topel ML; Liu C; Mujahid MS -
Neighborhood characteristics and ideal cardiovascular health among Black adults: results from the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity.
Ann Epidemiol Volume: 65 Page(s): 120.e1 - 120.e10
01/01/2022 Authors: Islam SJ; Kim JH; Baltrus P; Topel ML; Liu C; Ko Y-A; Mujahid MS; Vaccarino V; Sims M; Mubasher M -
Association Between Early Trauma and Ideal Cardiovascular Health Among Black Americans: Results From the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity.
Circ Cardiovasc Qual Outcomes Volume: 14 Page(s): e007904
09/01/2021 Authors: Islam SJ; Hwan Kim J; Joseph E; Topel M; Baltrus P; Liu C; Ko Y-A; Almuwaqqat Z; Mujahid MS; Sims M -
Experience With Cardiology-Oriented Outcomes in Critically Ill Patients With Coronavirus Disease 2019.
Crit Care Explor Volume: 2 Page(s): e0288
12/01/2020 Authors: Connor-Schuler R; Wong AI; Shah A; Fiza B; Lyle M; Ramonell R; Hockstein M; Chang G; Markham D; Searles C