Publications

• Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone.
  Nat Biomed Eng Volume: 9 Page(s): 754 - 771
  05/01/2025 Authors: Wu M; Yang H; Liu S; Jiang L; Liang T; Wang Y; Zhu M; Song X; Liu H; Shen J
• SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
  Nat Commun Volume: 15 Page(s): 5629
  07/04/2024 Authors: Chouhan S; Sridaran D; Weimholt C; Luo J; Li T; Hodgson MC; Santos LN; Le Sommer S; Fang B; Koomen JM
• Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity.
  Sci Adv Volume: 9 Page(s): eadf9522
  12/08/2023 Authors: Chen C; Zheng H; Horwitz EM; Ando S; Araki K; Zhao P; Li Z; Ford ML; Ahmed R; Qu C-K
• AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling.
  Stem Cell Res Ther Volume: 14 Page(s): 322
  11/08/2023 Authors: Li D; Armand LC; Sun F; Hwang H; Wolfson D; Rampoldi A; Liu R; Forghani P; Hu X; Yu W-M
• Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice.
  Elife Volume: 12
  09/06/2023 Authors: Zheng H; Li Q; Li S; Li Z; Brotto M; Weiss D; Prosdocimo D; Xu C; Reddy A; Puchowicz M
• Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
  Sci Rep Volume: 12 Page(s): 21832
  12/17/2022 Authors: Yan Y; Chen C; Li Z; Zhang J; Park N; Qu C-K
• Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
  Cell Chem Biol Volume: 29 Page(s): 1200 - 1208.e6
  07/21/2022 Authors: Zhang R; Chen D; Fan H; Wu R; Tu J; Zhang FQ; Wang M; Zheng H; Qu C-K; Elf SE
• JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1.
  Blood Adv Volume: 6 Page(s): 200 - 206
  01/11/2022 Authors: Yan Y; Dong L; Chen C; Bunting KD; Li Q; Stieglitz E; Loh ML; Qu C-K
• Methylation of dual-specificity phosphatase 4 controls cell differentiation.
  Cell Rep Volume: 36 Page(s): 109421
  07/27/2021 Authors: Su H; Jiang M; Senevirathne C; Aluri S; Zhang T; Guo H; Xavier-Ferrucio J; Jin S; Tran N-T; Liu S-M
• Decreased cell stiffness enhances leukemia development and progression.
  Leukemia Volume: 34 Page(s): 2493 - 2497
  09/01/2020 Authors: Hu L; Ni F; Wang X; Fay ME; Young KM; Lam WA; Sulchek TA; Qu C-K
• Germline mutations: many roles in leukemogenesis.
  Curr Opin Hematol Volume: 27 Page(s): 288 - 293
  07/01/2020 Authors: Chen KZ; Kazi R; Porter CC; Qu C-K
• Targeting HIF-1 in combination with PPAR activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes.
  J Mol Cell Cardiol Volume: 132 Page(s): 120 - 135
  07/01/2019 Authors: Gentillon C; Li D; Duan M; Yu W-M; Preininger MK; Jha R; Rampoldi A; Saraf A; Gibson GC; Qu C-K
• Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
  Cell Stem Cell Volume: 24 Page(s): 608 - 620.e6
  04/04/2019 Authors: Ni F; Yu W-M; Wang X; Fay ME; Young KM; Qiu Y; Lam WA; Sulchek TA; Cheng T; Scadden DT
• Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression.
  Nat Metab Volume: 1 Page(s): 390 - 403
  03/01/2019 Authors: Ni F; Yu W-M; Li Z; Graham DK; Jin L; Kang S; Rossi MR; Li S; Broxmeyer HE; Qu C-K
• Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.
  J Med Chem Volume: 62 Page(s): 1125 - 1137
  02/14/2019 Authors: Wu X; Xu G; Li X; Xu W; Li Q; Liu W; Kirby KA; Loh ML; Li J; Sarafianos SG
• The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
  J Pathol Volume: 247 Page(s): 135 - 146
  01/01/2019 Authors: Gagn-Sansfacon J; Langlois A; Langlois M-J; Coulombe G; Tremblay S; Vaillancourt-Lavigueur V; Qu C-K; Menendez A; Rivard N
• Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
  Cancer Discov Volume: 8 Page(s): 1438 - 1457
  11/01/2018 Authors: Hayashi Y; Zhang Y; Yokota A; Yan X; Liu J; Choi K; Li B; Sashida G; Peng Y; Xu Z
• Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
  Sci Adv Volume: 4 Page(s): eaat2681
  10/01/2018 Authors: Zheng H; Yu W-M; Shen J; Kang S; Hambardzumyan D; Li JY; Shen Y; Kenney AM; Chen J; Qu C-K
• Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis.
  Exp Hematol Volume: 66 Page(s): 17 - 26
  10/01/2018 Authors: Miller LH; Qu C-K; Pauly M
• MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
  Cancer Cell Volume: 34 Page(s): 315 - 330.e7
  08/13/2018 Authors: Jin L; Chun J; Pan C; Li D; Lin R; Alesi GN; Wang X; Kang H-B; Song L; Wang D
• Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice.
  Oncotarget Volume: 9 Page(s): 21831 - 21843
  04/24/2018 Authors: Tarnawsky SP; Yu W-M; Qu C-K; Chan RJ; Yoder MC
• Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
  Sci Signal Volume: 11
  03/20/2018 Authors: Zheng H; Yu W-M; Waclaw RR; Kontaridis MI; Neel BG; Qu C-K
• Factor XII and uPAR upregulate neutrophil functions to influence wound healing.
  J Clin Invest Volume: 128 Page(s): 944 - 959
  03/01/2018 Authors: Stavrou EX; Fang C; Bane KL; Long AT; Naudin C; Kucukal E; Gandhi A; Brett-Morris A; Mumaw MM; Izadmehr S
• The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
  Mol Cell Volume: 69 Page(s): 87 - 99.e7
  01/04/2018 Authors: Jin L; Chun J; Pan C; Kumar A; Zhang G; Ha Y; Li D; Alesi GN; Kang Y; Zhou L
• DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms.
  Leukemia Volume: 31 Page(s): 2468 - 2478
  11/01/2017 Authors: O'Leary HA; Capitano M; Cooper S; Mantel C; Boswell HS; Kapur R; Ramdas B; Chan R; Deng L; Qu C-K
• CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.
  Blood Volume: 130 Page(s): 1471 - 1474
  09/21/2017 Authors: Dong L; Zheng H; Qu C-K
• Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
  Leukemia Volume: 31 Page(s): 1415 - 1422
  06/01/2017 Authors: Liu W; Yu W-M; Zhang J; Chan RJ; Loh ML; Zhang Z; Bunting KD; Qu C-K
• 6 HIF1A SIGNALING IS A CENTRAL PATHOBIOLOGIC MEDIATOR OF MDS
  Volume: 55 Page(s): S6 - S6
  04/01/2017 Authors: Hayashi Y; Zhang Y; Yan X; Sashida G; Chetal K; Olsson A; Harada H; Shih LY; Tse W; Bridges J
• Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
  Nature Volume: 539 Page(s): 304 - 308
  11/10/2016 Authors: Dong L; Yu W-M; Zheng H; Loh ML; Bunting ST; Pauly M; Huang G; Zhou M; Broxmeyer HE; Scadden DT
• Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine.
  Leuk Res Volume: 50 Page(s): 132 - 140
  11/01/2016 Authors: Sabnis HS; Bradley HL; Tripathi S; Yu W-M; Tse W; Qu C-K; Bunting KD
• Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.
  Cancer Cell Volume: 30 Page(s): 623 - 636
  10/10/2016 Authors: Gu L; Zhang H; Liu T; Zhou S; Du Y; Xiong J; Yi S; Qu C-K; Fu H; Zhou M
• SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
  Oncotarget Volume: 7 Page(s): 65676 - 65695
  10/04/2016 Authors: Gagn-Sansfaon J; Coulombe G; Langlois M-J; Langlois A; Paquet M; Carrier J; Feng G-S; Qu C-K; Rivard N
• A metabolic stress-induced cell cycle checkpoint in stem cells.
  Cell Cycle Volume: 15 Page(s): 2539 - 2540
  10/01/2016 Authors: Ni F; Qu C-K
• Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis.
  Curr Opin Hematol Volume: 23 Page(s): 339 - 345
  07/01/2016 Authors: Seshadri M; Qu C-K
• A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
  Oncotarget Volume: 7 Page(s): 5664 - 5676
  02/02/2016 Authors: Hu Z; Wang X; Fang H; Liu Y; Chen D; Zhang Q; Liu X; Wei D; Qu C; Wang S
• Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
  Proc Natl Acad Sci U S A Volume: 113 Page(s): 984 - 989
  01/26/2016 Authors: Liu X; Zheng H; Li X; Wang S; Meyerson HJ; Yang W; Neel BG; Qu C-K
• Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
  Blood Volume: 125 Page(s): 1562 - 1565
  03/05/2015 Authors: Liu X; Zheng H; Yu W-M; Cooper TM; Bunting KD; Qu C-K
• Critical Role of Stat5 in the Maintenance of Leukemic Stem Cells in Ptpn11-Associated Juvenile Myelomonocytic Leukemia
  Volume: 124
  12/06/2014 Authors: Liu W; Liu X; Yu W-M; Bunting KD; Qu C-K
• Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts.
  Mol Cell Biochem Volume: 392 Page(s): 31 - 37
  07/01/2014 Authors: Liu J; Lv Y; Liu Q-H; Qu C-K; Shen J
• Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells.
  J Biol Chem Volume: 289 Page(s): 251 - 263
  01/03/2014 Authors: Li Q; Hakimi P; Liu X; Yu W-M; Ye F; Fujioka H; Raza S; Shankar E; Tang F; Dunwoodie SL
• The hematopoietic stem cell landscape.
  Methods Mol Biol Volume: 1185 Page(s): 3 - 6
  01/01/2014 Authors: Bunting KD; Qu C-K
• Hematopoietic Stem Cell Protocols Third Edition Preface
  Volume: 1185 Page(s): V - V
  01/01/2014 Authors: Bunting KD; Qu C-K
• Flow cytometric analysis of signaling and apoptosis in hematopoietic stem cells.
  Methods Mol Biol Volume: 1185 Page(s): 79 - 87
  01/01/2014 Authors: Dong L; Qu C-K
• Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
  J Med Chem Volume: 56 Page(s): 7212 - 7221
  09/26/2013 Authors: Liu W; Yu B; Xu G; Xu W-R; Loh ML; Tang L-D; Qu C-K
• Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.
  J Biol Chem Volume: 288 Page(s): 25727 - 25738
  09/06/2013 Authors: Zheng H; Li S; Hsu P; Qu C-K
• Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies.
  Mol Cancer Ther Volume: 12 Page(s): 1738 - 1748
  09/01/2013 Authors: Yu B; Liu W; Yu W-M; Loh ML; Alter S; Guvench O; Mackerell AD; Tang L-D; Qu C-K
• Metabolic plasticity and hematopoietic stem cell biology.
  Curr Opin Hematol Volume: 20 Page(s): 289 - 294
  07/01/2013 Authors: Hsu P; Qu C-K
• Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
  Cell Stem Cell Volume: 12 Page(s): 62 - 74
  01/03/2013 Authors: Yu W-M; Liu X; Shen J; Jovanovic O; Pohl EE; Gerson SL; Finkel T; Broxmeyer HE; Qu C-K
• Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
  PLoS One Volume: 8 Page(s): e63152
  01/01/2013 Authors: Xu D; Zheng H; Yu W-M; Qu C-K
• Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
  Cancer Res Volume: 72 Page(s): 5296 - 5306
  10/15/2012 Authors: Liu X; Zheng H; Qu C-K
• Molecular-targeted therapies for hematologic malignancies.
  Adv Hematol Volume: 2012 Page(s): 606423
  01/01/2012 Authors: Bunting KD; Qu C-K; Tomasson MH
• Molecular targets for the treatment of juvenile myelomonocytic leukemia.
  Adv Hematol Volume: 2012 Page(s): 308252
  01/01/2012 Authors: Liu X; Sabnis H; Bunting KD; Qu C-K
• Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.
  Adv Biol Regul Volume: 52 Page(s): 98 - 107
  01/01/2012 Authors: Hnia K; Kretz C; Amoasii L; Bhm J; Liu X; Messaddeq N; Qu C-K; Laporte J
• A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
  Mol Cell Biol Volume: 31 Page(s): 4902 - 4916
  12/01/2011 Authors: Shen J; Liu X; Yu W-M; Liu J; Nibbelink MG; Guo C; Finkel T; Qu C-K
• Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
  J Exp Med Volume: 208 Page(s): 1977 - 1988
  09/26/2011 Authors: Xu D; Liu X; Yu W-M; Meyerson HJ; Guo C; Gerson SL; Qu C-K
• Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase.
  Proteins Volume: 79 Page(s): 1573 - 1588
  05/01/2011 Authors: Darian E; Guvench O; Yu B; Qu C-K; MacKerell AD
• Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor.
  J Biol Chem Volume: 285 Page(s): 40312 - 40321
  12/17/2010 Authors: Touchberry CD; Bales IK; Stone JK; Rohrberg TJ; Parelkar NK; Nguyen T; Fuentes O; Liu X; Qu C-K; Andresen JJ
• A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
  Blood Volume: 116 Page(s): 3611 - 3621
  11/04/2010 Authors: Xu D; Wang S; Yu W-M; Chan G; Araki T; Bunting KD; Neel BG; Qu C-K
• Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.
  Aging (Albany NY) Volume: 2 Page(s): 504 - 513
  08/01/2010 Authors: Romero-Suarez S; Shen J; Brotto L; Hall T; Mo C; Valdivia HH; Andresen J; Wacker M; Nosek TM; Qu C-K
• Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
  Nat Cell Biol Volume: 11 Page(s): 769 - 776
  06/01/2009 Authors: Shen J; Yu W-M; Brotto M; Scherman JA; Guo C; Stoddard C; Nosek TM; Valdivia HH; Qu C-K
• Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
  J Biol Chem Volume: 284 Page(s): 913 - 920
  01/09/2009 Authors: Wang S; Yu W-M; Zhang W; McCrae KR; Neel BG; Qu C-K
• Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.
  J Med Chem Volume: 51 Page(s): 7396 - 7404
  12/11/2008 Authors: Yu W-M; Guvench O; Mackerell AD; Qu C-K
• MEDI 116-Discovery of selective SHP-2 phosphatase inhibitors via in silico screening and experimental assay
  Volume: 236
  08/17/2008 Authors: Guvench O; Yu W-M; Qu C-K; MacKerell AD
• Protein tyrosine phosphatases in the JAK/STAT pathway.
  Front Biosci Volume: 13 Page(s): 4925 - 4932
  05/01/2008 Authors: Xu D; Qu C-K
• In vitro hematopoietic differentiation of murine embryonic stem cells.
  Methods Mol Biol Volume: 430 Page(s): 103 - 118
  01/01/2008 Authors: Shen J; Qu C-K
• Abnormal hematopoiesis in Gab2 mutant mice.
  Blood Volume: 110 Page(s): 116 - 124
  07/01/2007 Authors: Zhang Y; Diaz-Flores E; Li G; Wang Z; Kang Z; Haviernikova E; Rowe S; Qu C-K; Tse W; Shannon KM
• SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.
  Proc Natl Acad Sci U S A Volume: 104 Page(s): 5419 - 5424
  03/27/2007 Authors: Amin ARMR; Thakur VS; Paul RK; Feng GS; Qu C-K; Mukhtar H; Agarwal ML
• Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft.
  BMC Struct Biol Volume: 7 Page(s): 14
  03/22/2007 Authors: Guvench O; Qu C-K; MacKerell AD
• SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.
  Blood Volume: 109 Page(s): 778 - 785
  01/15/2007 Authors: Chen J; Yu W-M; Daino H; Broxmeyer HE; Druker BJ; Qu C-K
• Complex systems biology approach to understanding coordination of JAK-STAT signaling.
  Biosystems Volume: 90 Page(s): 830 - 842
  01/01/2007 Authors: Soebiyanto RP; Sreenath SN; Qu C-K; Loparo KA; Bunting KD
• Molecular dynamics studies on the closed to open transition of the SHP-2N-SH2-domain phosphotyrosine-peptide binding cleft
  Page(s): 210A - 210A
  01/01/2007 Authors: Guvench O; Qu C-K; MacKerell AD
• Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts.
  Cell Signal Volume: 18 Page(s): 2049 - 2055
  11/01/2006 Authors: Duan H-F; Qu C-K; Zhang Q-W; Yu W-M; Wang H; Wu C-T; Wang L-S
• Rapid induction and activation of Tec tyrosine kinase in liver regeneration.
  J Gastroenterol Hepatol Volume: 21 Page(s): 668 - 673
  04/01/2006 Authors: Wang S-Y; Li F-F; Zheng H; Yu K-K; Ni F; Yang X-M; Qu C-K; Li J
• Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.
  J Biol Chem Volume: 281 Page(s): 5426 - 5434
  03/03/2006 Authors: Yu W-M; Daino H; Chen J; Bunting KD; Qu C-K
• Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
  J Biol Chem Volume: 281 Page(s): 3711 - 3721
  02/10/2006 Authors: Seo D-W; Li H; Qu C-K; Oh J; Kim Y-S; Diaz T; Wei B; Han J-W; Stetler-Stevenson WG
• SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively.
  J Biol Chem Volume: 280 Page(s): 42701 - 42706
  12/30/2005 Authors: Yuan L; Yu W-M; Xu M; Qu C-K
• Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on IL-3 signaling.
  Volume: 106 Page(s): 643A - 643A
  11/16/2005 Authors: Yu WM; Daino H; Chen J; Bunting KD; Qu CK
• Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP.
  EMBO J Volume: 24 Page(s): 2331 - 2341
  07/06/2005 Authors: Kwon J; Qu C-K; Maeng J-S; Falahati R; Lee C; Williams MS
• Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1.
  J Immunol Volume: 174 Page(s): 1013 - 1019
  01/15/2005 Authors: Yu W-M; Wang S; Keegan AD; Williams MS; Qu C-K
• Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression.
  J Leukoc Biol Volume: 76 Page(s): 484 - 490
  08/01/2004 Authors: Bunting KD; Yu W-M; Bradley HL; Haviernikova E; Kelly-Welch AE; Keegan AD; Qu C-K
• A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival.
  Oncogene Volume: 23 Page(s): 3659 - 3669
  04/29/2004 Authors: Chen J; Yu W-M; Bunting KD; Qu C-K
• TcR stimulated generation of reactive oxygen species regulates Gads-SLP-76-ADAP via oxidative modification of SHP-2
  Volume: 18 Page(s): A55 - A56
  03/23/2004 Authors: Kwon J; Qu CK; Koretzky GA; Williams MS
• Hepatocyte growth factor-induced proliferation of hepatic stem-like cells depends on activation of NF-kappaB.
  J Hepatol Volume: 40 Page(s): 391 - 398
  03/01/2004 Authors: Yao P; Zhan Y; Xu W; Li C; Yue P; Xu C; Hu D; Qu C-K; Yang X
• SHP-2 tyrosine phosphatase negatively regulates hematopoietic cell survival by dephosphorylation of Stat5.
  Volume: 102 Page(s): 836A - 836A
  11/16/2003 Authors: Chen J; Yu WM; Qu CK
• DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.
  J Biol Chem Volume: 278 Page(s): 42812 - 42820
  10/31/2003 Authors: Yuan L; Yu W-M; Qu C-K
• Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6.
  J Immunol Volume: 171 Page(s): 4203 - 4209
  10/15/2003 Authors: Zamorano J; Rivas MD; Garcia-Trinidad A; Qu C-K; Keegan AD
• Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.
  Oncogene Volume: 22 Page(s): 5995 - 6004
  09/04/2003 Authors: Yu W-M; Hawley TS; Hawley RG; Qu C-K
• Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.
  J Biol Chem Volume: 278 Page(s): 15208 - 15216
  04/25/2003 Authors: Yuan L; Yu W-M; Yuan Z; Haudenschild CC; Qu C-K
• Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome.
  J Biol Chem Volume: 278 Page(s): 3903 - 3911
  02/07/2003 Authors: Hanson EM; Dickensheets H; Qu C-K; Donnelly RP; Keegan AD
• SHP-2 tyrosine phosphatase overrides the role of SHP-1 phosphatase in interleukin-3 signaling, functioning in both catalytic dependent and independent manners.
  Volume: 100 Page(s): 518A - 518A
  11/16/2002 Authors: Yu WM; Hawley TS; Hawley RG; Qu CK
• Immortalization of yolk sac-derived precursor cells.
  Blood Volume: 100 Page(s): 3828 - 3831
  11/15/2002 Authors: Yu W-M; Hawley TS; Hawley RG; Qu C-K
• Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response.
  Biochim Biophys Acta Volume: 1592 Page(s): 297 - 301
  11/11/2002 Authors: Qu C-K
• Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
  Mol Cell Biol Volume: 22 Page(s): 3230 - 3236
  05/01/2002 Authors: Shen R; Ouyang Y-B; Qu C-K; Alonso A; Sperzel L; Mustelin T; Kaplan MH; Feng G-S
• Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration.
  Blood Volume: 99 Page(s): 2351 - 2359
  04/01/2002 Authors: Yu W-M; Hawley TS; Hawley RG; Qu C-K
• Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.
  Blood Volume: 97 Page(s): 911 - 914
  02/15/2001 Authors: Qu CK; Nguyen S; Chen J; Feng GS
• The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions.
  Cell Res Volume: 10 Page(s): 279 - 288
  12/01/2000 Authors: Qu CK
• Stat4, BCL-6, p21(cip1/waf1), SHP-1, SHIP, and Nf1 are implicated as common mediators of myelosuppression by CC, CXC, and C chemokines through use of mice functionally deleted in these intracellular molecules.
  BLOOD Volume: 94 Page(s): 686A - 686A
  11/15/1999 Authors: Broxmeyer HE; Kim CH; Cooper S; Hangoc G; Feng GS; Qu CK; Krystal G; Humphries RK; Kaplan M; Dent A
• Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.
  J Exp Med Volume: 190 Page(s): 681 - 690
  09/06/1999 Authors: Kim CH; Qu CK; Hangoc G; Cooper S; Anzai N; Feng GS; Broxmeyer HE
• Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
  Proc Natl Acad Sci U S A Volume: 96 Page(s): 8528 - 8533
  07/20/1999 Authors: Qu CK; Yu WM; Azzarelli B; Feng GS
• Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.
  Mol Cell Biol Volume: 18 Page(s): 6075 - 6082
  10/01/1998 Authors: Qu CK; Yu WM; Azzarelli B; Cooper S; Broxmeyer HE; Feng GS
• Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion.
  J Biol Chem Volume: 273 Page(s): 21125 - 21131
  08/14/1998 Authors: Yu DH; Qu CK; Henegariu O; Lu X; Feng GS
• Shp-2 has a positive regulatory role in ES cell differentiation and proliferation.
  Oncogene Volume: 17 Page(s): 433 - 439
  07/30/1998 Authors: Qu CK; Feng GS
• Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cell lines.
  Oncogene Volume: 17 Page(s): 441 - 448
  07/30/1998 Authors: Lu X; Qu CK; Shi ZQ; Feng GS
• A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.
  Mol Cell Biol Volume: 17 Page(s): 5499 - 5507
  09/01/1997 Authors: Qu CK; Shi ZQ; Shen R; Tsai FY; Orkin SH; Feng GS
• An essential role of SHP-2 in mammalian hematopoietic development.
  BLOOD Volume: 88 Page(s): 2627 - 2627
  11/15/1996 Authors: Qu CK; Shen R; Tsai FY; Hu DP; Feng GS