Chrystal Paulos
Overview
Prior to joining Emory, Dr. Paulos was the Cecilia and Vincent Peng Endowed Chair in Melanoma at the Medical University of South Carolina. She also served as co-leader of the Cancer Immunology Research Program and director of the Adoptive Cancer Immunotherapy Program at Hollings Cancer Center in Charleston, SC.
Dr. Paulos received her PhD in Biochemistry from Purdue University in West Lafayette, IN. She completed her post-doctoral training in genetherapy at the University of Pennsylvania in Philadelphia, and in tumor immunology at the National Institutes of Health in Bethesda, MD.
The objective of Dr. Paulos' research is to develop novel T cell-based therapies for patients with melanoma. Her laboratory seeks to identify mechanisms underlying protective immunity in solid tumors, with an emphasis on adoptive T cell transfer (ACT) therapy. By combining basic and translational understanding of human T cells in clinical studies with mechanistic studies in relevant mouse models and in investigator-initiated clinical trials in patients, her research team has contributed significant insight into the various roles of how to mount T cell memory responses to tumors.
Academic Appointment
- David H. Lawson Professorship in Cancer Research, Emory University School of Medicine
- Acting Associate Professor, Department of Microbiology and Immunology, Emory University School of Medicine
Education
Degrees
- BS with Honors from Truman State University, Kirksville, MO, Class of 1997
- PhD in Biochemistry from Purdue University, West Lafayette, IN, 1998-2004
Research
Focus
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To develop novel T cell-based therapies for patients with melanoma.
Dr. Paulo's laboratory seeks to identify mechanisms underlying protective immunity in solid tumors with an emphasis on adoptive T cell transfer (ACT) therapy.
Publications
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XL888 and pembrolizumab modulate the immune landscape of colorectal tumors in a phase Ib/II clinical trial.
Oncoimmunology Volume: 14 Page(s): 2475620
12/01/2025 Authors: Phillips MJ; Alese OB; Horvat NK; Greene E; Gbolahan OB; Coleman K; Doxie DB; Parihar V; Mahdi ZK; McCook-Veal A -
MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer.
Nat Commun Volume: 16 Page(s): 3552
04/15/2025 Authors: Chi JJ; Xie P; Cheng MH; Zhu Y; Cui X; Watson J; Zeng L; Uddin A; Nguyen H; Li L -
Combination radiation and PD-L1 enhance tumor control by stimulating CD8+PD-1+TCF-1+T cells in the tumor-draining lymph node.
Nat Commun Volume: 16 Page(s): 3522
04/14/2025 Authors: Shen Y; Connolly E; Aiello M; Zhou C; Chappa P; Song H; Tippitak P; Clark T; Cardenas M; Prokhnevska N -
Macrophage-derived Fgl2 dampens antitumor immunity through regulation of FcRIIB+CD8+ T cells in melanoma.
JCI Insight Volume: 10
03/24/2025 Authors: Bennion KB; Miranda R Bazzano J; Liu D; Wagener M; Paulos CM; Ford ML -
CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors.
J Immunother Cancer Volume: 13
02/11/2025 Authors: Mohamed AO; Boone DT; Ferry SL; Peck MC; Santos AM; Soderholm HE; Wittling MC; Paulos C; Turk MJ; Huang YH -
A Paradigm Shift in Tumor Immunology: Th17 Cells and TGF in Intestinal Cancer Initiation.
Cancer Res Volume: 84 Page(s): 3919 - 3920
12/02/2024 Authors: Wyatt MM; Paulos CM -
Editor's Note: Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor.
Cancer Res Volume: 84 Page(s): 3702
11/04/2024 Authors: Zhao Y; Moon E; Carpenito C; Paulos CM; Liu X; Brennan AL; Chew A; Carroll RG; Scholler J; Levine BL -
Strategies for Improving CAR T Cell Persistence in Solid Tumors.
Cancers (Basel) Volume: 16
08/16/2024 Authors: Wittling MC; Cole AC; Brammer B; Diatikar KG; Schmitt NC; Paulos CM -
Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells.
J Immunother Cancer Volume: 12
06/30/2024 Authors: Wittling MC; Knochelmann HM; Wyatt MM; Rangel Rivera GO; Cole AC; Lesinski GB; Paulos CM -
CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcRIIB.
Nat Commun Volume: 15 Page(s): 5280
06/20/2024 Authors: Bennion KB; Liu D; Dawood AS; Wyatt MM; Alexander KL; Abdel-Hakeem MS; Paulos CM; Ford ML