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Profile

Chethan Pandarinath

  • Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
    Associate Professor
  • chethan.pandarinath@emory.edu
  • Lab website
Head shot of Chethan Pandarinath

Overview

Our work centers on understanding how large populations of neurons in the brain perform computations and represent intention. We use these insights to develop high-performance, robust, and practical assistive devices for people with disabilities and neurological disorders.

Academic Appointment

  • Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Emory University

Education

Degrees

  • PhD, Electrical Engineering from Cornell University
  • BS, BS, BA, Computer Engineering, Physics, Science Technology & Society from North Carolina State University

Research

Publications

  • Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS.
    J Neurosci Volume: 44
    05/15/2024 Authors: Lee W-H; Karpowicz BM; Pandarinath C; Rouse AG
  • BRAND: a platform for closed-loop experiments with deep network models.
    J Neural Eng Volume: 21
    04/17/2024 Authors: Ali YH; Bodkin K; Rigotti-Thompson M; Patel K; Card NS; Bhaduri B; Nason-Tomaszewski SR; Mifsud DM; Hou X; Nicolas C
  • Identifying distinct neural features between the initial and corrective phases of precise reaching using AutoLFADS.

    02/04/2024 Authors: Lee W-H; Karpowicz BM; Pandarinath C; Rouse AG
  • Myomatrix arrays for high-definition muscle recording.
    Elife Volume: 12
    12/19/2023 Authors: Chung B; Zia M; Thomas KA; Michaels JA; Jacob A; Pack A; Williams MJ; Nagapudi K; Teng LH; Arrambide E
  • Pseudo-linear Summation explains Neural Geometry of Multi-finger Movements in Human Premotor Cortex.
    bioRxiv
    10/12/2023 Authors: Shah NP; Avansino D; Kamdar F; Nicolas C; Kapitonava A; Vargas-Irwin C; Hochberg L; Pandarinath C; Shenoy K; Willett FR
  • Myomatrix arrays for high-definition muscle recording.
    bioRxiv
    09/19/2023 Authors: Chung B; Zia M; Thomas KA; Michaels JA; Jacob A; Pack A; Williams MJ; Nagapudi K; Teng LH; Arrambide E
  • Expressive dynamics models with nonlinear injective readouts enable reliable recovery of latent features from neural activity.
    ArXiv
    09/12/2023 Authors: Versteeg C; Sedler AR; McCart JD; Pandarinath C
  • lfads-torch: A modular and extensible implementation of latent factor analysis via dynamical systems

    09/03/2023 Authors: Sedler AR; Pandarinath C
  • BRAND: A platform for closed-loop experiments with deep network models.
    bioRxiv
    08/12/2023 Authors: Ali YH; Bodkin K; Rigotti-Thompson M; Patel K; Card NS; Bhaduri B; Nason-Tomaszewski SR; Mifsud DM; Hou X; Nicolas C
  • Krishna Shenoy (1968-2023).
    Neuron Volume: 111 Page(s): 764 - 766
    03/15/2023 Authors: Batista AP; Pandarinath C; Yu BM
  • Expressive architectures enhance interpretability of dynamics-based neural population models.
    Neuron Behav Data Anal Theory Volume: 2023
    01/01/2023 Authors: Sedler AR; Versteeg C; Pandarinath C
  • High-performance neural population dynamics modeling enabled by scalable computational infrastructure.
    J Open Source Softw Volume: 8
    01/01/2023 Authors: Patel AN; Sedler AR; Huang J; Pandarinath C; Gilja V
  • Expressive architectures enhance interpretability of dynamics-based neural population models

    12/07/2022 Authors: Sedler AR; Versteeg C; Pandarinath C
  • A large-scale neural network training framework for generalized estimation of single-trial population dynamics.
    Nat Methods Volume: 19 Page(s): 1572 - 1577
    12/01/2022 Authors: Keshtkaran MR; Sedler AR; Chowdhury RH; Tandon R; Basrai D; Nguyen SL; Sohn H; Jazayeri M; Miller LE; Pandarinath C
  • A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution.
    Nat Neurosci Volume: 25 Page(s): 1724 - 1734
    12/01/2022 Authors: Zhu F; Grier HA; Tandon R; Cai C; Agarwal A; Giovannucci A; Kaufman MT; Pandarinath C
  • Estimating muscle activation from EMG using deep learning-based dynamical systems models.
    J Neural Eng Volume: 19
    05/19/2022 Authors: Wimalasena LN; Braun JF; Keshtkaran MR; Hofmann D; Gallego J; Alessandro C; Tresch MC; Miller LE; Pandarinath C
  • The science and engineering behind sensitized brain-controlled bionic hands.
    Physiol Rev Volume: 102 Page(s): 551 - 604
    04/01/2022 Authors: Pandarinath C; Bensmaia SJ
  • Neural Latents Benchmark '21: Evaluating latent variable models of neural population activity

    09/09/2021 Authors: Pei F; Ye J; Zoltowski D; Wu A; Chowdhury RH; Sohn H; O'Doherty JE; Shenoy KV; Kaufman MT; Churchland M
  • Representation learning for neural population activity with Neural Data Transformers

    08/02/2021 Authors: Ye J; Pandarinath C
  • From unstable input to robust output.
    Nat Biomed Eng Volume: 4 Page(s): 665 - 667
    07/01/2020 Authors: Wimalasena LN; Miller LE; Pandarinath C
  • The Representation of Finger Movement and Force in Human Motor and Premotor Cortices.
    eNeuro Volume: 7
    01/01/2020 Authors: Flint RD; Tate MC; Li K; Templer JW; Rosenow JM; Pandarinath C; Slutzky MW
  • Principled BCI Decoder Design and Parameter Selection Using a Feedback Control Model.
    Sci Rep Volume: 9 Page(s): 8881
    06/20/2019 Authors: Willett FR; Young DR; Murphy BA; Memberg WD; Blabe CH; Pandarinath C; Stavisky SD; Rezaii P; Saab J; Walter BL
  • Volitional control of single-electrode high gamma local field potentials by people with paralysis.
    J Neurophysiol Volume: 121 Page(s): 1428 - 1450
    04/01/2019 Authors: Milekovic T; Bacher D; Sarma AA; Simeral JD; Saab J; Pandarinath C; Yvert B; Sorice BL; Blabe C; Oakley EM
  • Brain implants that let you speak your mind.
    Nature Volume: 568 Page(s): 466 - 467
    04/01/2019 Authors: Pandarinath C; Ali YH
  • Publisher Correction: Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements.
    Sci Rep Volume: 9 Page(s): 5528
    03/28/2019 Authors: Stavisky SD; Kao JC; Nuyujukian P; Pandarinath C; Blabe C; Ryu SI; Hochberg LR; Henderson JM; Shenoy KV
  • Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements.
    Sci Rep Volume: 8 Page(s): 16357
    11/05/2018 Authors: Stavisky SD; Kao JC; Nuyujukian P; Pandarinath C; Blabe C; Ryu SI; Hochberg LR; Henderson JM; Shenoy KV
  • Latent Factors and Dynamics in Motor Cortex and Their Application to Brain-Machine Interfaces.
    J Neurosci Volume: 38 Page(s): 9390 - 9401
    10/31/2018 Authors: Pandarinath C; Ames KC; Russo AA; Farshchian A; Miller LE; Dyer EL; Kao JC
  • Inferring single-trial neural population dynamics using sequential auto-encoders.
    Nat Methods Volume: 15 Page(s): 805 - 815
    10/01/2018 Authors: Pandarinath C; O'Shea DJ; Collins J; Jozefowicz R; Stavisky SD; Kao JC; Trautmann EM; Kaufman MT; Ryu SI; Hochberg LR
  • A Comparison of Intention Estimation Methods for Decoder Calibration in Intracortical Brain-Computer Interfaces.
    IEEE Trans Biomed Eng Volume: 65 Page(s): 2066 - 2078
    09/01/2018 Authors: Willett FR; Murphy BA; Young DR; Memberg WD; Blabe CH; Pandarinath C; Franco B; Saab J; Walter BL; Sweet JA
  • Feasibility of Automatic Error Detect-and-Undo System in Human Intracortical Brain-Computer Interfaces.
    IEEE Trans Biomed Eng Volume: 65 Page(s): 1771 - 1784
    08/01/2018 Authors: Even-Chen N; Stavisky SD; Pandarinath C; Nuyujukian P; Blabe CH; Hochberg LR; Henderson JM; Shenoy KV
  • Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.
    J Neurophysiol Volume: 120 Page(s): 343 - 360
    07/01/2018 Authors: Milekovic T; Sarma AA; Bacher D; Simeral JD; Saab J; Pandarinath C; Sorice BL; Blabe C; Oakley EM; Tringale KR
  • Rapid calibration of an intracortical brain-computer interface for people with tetraplegia.
    J Neural Eng Volume: 15 Page(s): 026007
    04/01/2018 Authors: Brandman DM; Hosman T; Saab J; Burkhart MC; Shanahan BE; Ciancibello JG; Sarma AA; Milstein DJ; Vargas-Irwin CE; Franco B
  • Cortical control of a tablet computer by people with paralysis.
    PLoS One Volume: 13 Page(s): e0204566
    01/01/2018 Authors: Nuyujukian P; Albites Sanabria J; Saab J; Pandarinath C; Jarosiewicz B; Blabe CH; Franco B; Mernoff ST; Eskandar EN; Simeral JD
  • Signal-independent noise in intracortical brain-computer interfaces causes movement time properties inconsistent with Fitts' law.
    J Neural Eng Volume: 14 Page(s): 026010
    04/01/2017 Authors: Willett FR; Murphy BA; Memberg WD; Blabe CH; Pandarinath C; Walter BL; Sweet JA; Miller JP; Henderson JM; Shenoy KV
  • High performance communication by people with paralysis using an intracortical brain-computer interface.
    Elife Volume: 6
    02/21/2017 Authors: Pandarinath C; Nuyujukian P; Blabe CH; Sorice BL; Saab J; Willett FR; Hochberg LR; Shenoy KV; Henderson JM
  • Feedback control policies employed by people using intracortical brain-computer interfaces.
    J Neural Eng Volume: 14 Page(s): 016001
    02/01/2017 Authors: Willett FR; Pandarinath C; Jarosiewicz B; Murphy BA; Memberg WD; Blabe CH; Saab J; Walter BL; Sweet JA; Miller JP
  • LFADS - Latent Factor Analysis via Dynamical Systems

    08/22/2016 Authors: Sussillo D; Jozefowicz R; Abbott LF; Pandarinath C
  • Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface.
    Sci Transl Med Volume: 7 Page(s): 313ra179
    11/11/2015 Authors: Jarosiewicz B; Sarma AA; Bacher D; Masse NY; Simeral JD; Sorice B; Oakley EM; Blabe C; Pandarinath C; Gilja V
  • Clinical translation of a high-performance neural prosthesis.
    Nat Med Volume: 21 Page(s): 1142 - 1145
    10/01/2015 Authors: Gilja V; Pandarinath C; Blabe CH; Nuyujukian P; Simeral JD; Sarma AA; Sorice BL; Perge JA; Jarosiewicz B; Hochberg LR
  • Neural population dynamics in human motor cortex during movements in people with ALS.
    Elife Volume: 4 Page(s): e07436
    06/23/2015 Authors: Pandarinath C; Gilja V; Blabe CH; Nuyujukian P; Sarma AA; Sorice BL; Eskandar EN; Hochberg LR; Henderson JM; Shenoy KV
  • Progress toward Robust, High-Performance Intracortically Controlled Point-and-Click Communication for People with Locked-In Syndrome
    Volume: 76 Page(s): S125 - S125
    10/01/2014 Authors: Sarma AA; Jarosiewicz B; Bacher D; Pandarinath C; Nuyujukian P; Sorice BL; Blabe C; Simeral JD; Donoghue JP; Mernoff S
  • Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum.
    PLoS Pathog Volume: 10 Page(s): e1003854
    01/01/2014 Authors: Ukaegbu UE; Kishore SP; Kwiatkowski DL; Pandarinath C; Dahan-Pasternak N; Dzikowski R; Deitsch KW
  • A system for optically controlling neural circuits with very high spatial and temporal resolution.
    Volume: 2013
    11/01/2013 Authors: Pandarinath C; Carlson ET; Nirenberg S
  • High Performance Computer Cursor Control Using Neuronal Ensemble Recordings From the Motor Cortex of a Person With ALS
    Volume: 60 Page(s): 184 - 184
    08/01/2013 Authors: Henderson JM; Gilja V; Pandarinath C; Blabe C; Hochberg LR; Shenoy KV
  • Retinal prosthetic strategy with the capacity to restore normal vision.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 15012 - 15017
    09/11/2012 Authors: Nirenberg S; Pandarinath C
  • Symmetry breakdown in the ON and OFF pathways of the retina at night: functional implications.
    J Neurosci Volume: 30 Page(s): 10006 - 10014
    07/28/2010 Authors: Pandarinath C; Victor JD; Nirenberg S
  • How Neural Systems Adjust to Different Environments: An Intriguing Role for Gap Junction Coupling
    Volume: 51
    04/01/2010 Authors: Nirenberg S; Pandarinath C; Bomash I; Victor JD; Prusky GT; Tschetter WW
  • A novel mechanism for switching a neural system from one state to another.
    Front Comput Neurosci Volume: 4 Page(s): 2
    01/01/2010 Authors: Pandarinath C; Bomash I; Victor JD; Prusky GT; Tschetter WW; Nirenberg S
  • Ganglion cell adaptability: does the coupling of horizontal cells play a role?
    PLoS One Volume: 3 Page(s): e1714
    03/05/2008 Authors: Dedek K; Pandarinath C; Alam NM; Wellershaus K; Schubert T; Willecke K; Prusky GT; Weiler R; Nirenberg S
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