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Profile

Christopher Neufeldt

  • Department of Microbiology and Immunology
    Assistant Professor
  • (404) 727-0092
  • c.neufeldt@emory.edu
Head shot of Christopher Neufeldt

Overview

Dr. Neufeldt obtained his BSc in immunology and PhD in Cell Biology from the University of Alberta. Following his PhD, he moved to the University of Heidelberg where he continued his training in Molecular Virology in the Laboratory of Ralf Bartenschlager. During this time, his research focused on how virus infection alters host cell pathways. In 2021, Dr. Neufeldt joined the Emory faculty as an assistant professor in Microbiology and Immunology. Research in the Neufeldt lab uses innovative imaging techniques in combination with a range of molecular virology and cell biology tools to interrogate how positive-strand RNA virus infection manipulates cellular membrane systems to facilitate viral processes and limit immune activation.

Academic Appointment

  • Assistant Professor, Microbiology and Immunology, Emory University School of Medicine

Education

Degrees

  • Ph.D. from University of Alberta
  • B.Sc. (Immunology and Infection) from University of Alberta

Research

Publications

  • Inflammation-driven NF-B signaling represses ferroportin transcription in macrophages via HDAC1 and HDAC3.
    Blood Volume: 145 Page(s): 866 - 880
    02/20/2025 Authors: Marques O; Horvat NK; Zechner L; Colucci S; Sparla R; Zimmermann S; Neufeldt CJ; Altamura S; Qiu R; Mdder K
  • Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.
    iScience Volume: 28 Page(s): 111599
    01/17/2025 Authors: Freppel W; Barragan Torres VA; Uyar O; Anton A; Nouhi Z; Broquire M; Mazeaud C; Sow AA; Lveill A; Gilbert C
  • Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis.
    Elife Volume: 13
    11/20/2024 Authors: Mazeaud C; Pfister S; Owen JE; Pereira HS; Charbonneau F; Robinson ZE; Anton A; Bemis CL; Sow AA; Patel TR
  • Correction for Rasmussen et al., "Virology-the path forward".
    J Virol Volume: 98 Page(s): e0007424
    03/19/2024 Authors: Rasmussen AL; Gronvall GK; Lowen AC; Goodrum F; Alwine J; Andersen KG; Anthony SJ; Baines J; Banerjee A; Broadbent AJ
  • Virology-the path forward.
    J Virol Volume: 98 Page(s): e0179123
    01/23/2024 Authors: Rasmussen AL; Gronvall GK; Lowen AC; Goodrum F; Alwine J; Andersen KG; Anthony SJ; Baines J; Banerjee A; Broadbent AJ
  • Identification of host dependency factors involved in SARS-CoV-2 replication organelle formation through proteomics and ultrastructural analysis.
    J Virol Volume: 97 Page(s): e0087823
    11/30/2023 Authors: Pahmeier F; Lavacca T-M; Goellner S; Neufeldt CJ; Prasad V; Cerikan B; Rajasekharan S; Mizzon G; Haselmann U; Funaya C
  • Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
    Mol Cell Volume: 83 Page(s): 2559 - 2577.e8
    07/20/2023 Authors: Prasad V; Cerikan B; Stahl Y; Kopp K; Magg V; Acosta-Rivero N; Kim H; Klein K; Funaya C; Haselmann U
  • Virology under the Microscope-a Call for Rational Discourse.
    mSphere Volume: 8 Page(s): e0003423
    04/20/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
  • Virology under the Microscope-a Call for Rational Discourse.
    mBio Volume: 14 Page(s): e0018823
    02/28/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
  • Virology under the Microscope-a Call for Rational Discourse.
    J Virol Volume: 97 Page(s): e0008923
    02/28/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
  • Membrane architects: how positive-strand RNA viruses restructure the cell.
    J Gen Virol Volume: 103
    08/01/2022 Authors: Neufeldt CJ; Cortese M
  • The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters.
    mBio Volume: 13 Page(s): e0370521
    04/26/2022 Authors: Shytaj IL; Fares M; Gallucci L; Lucic B; Tolba MM; Zimmermann L; Adler JM; Xing N; Bushe J; Gruber AD
  • Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx: An antigen-detecting point-of-care device for SARS-CoV-2.
    Infection Volume: 50 Page(s): 395 - 406
    04/01/2022 Authors: Krger LJ; Klein JAF; Tobian F; Gaeddert M; Lainati F; Klemm S; Schnitzler P; Bartenschlager R; Cerikan B; Neufeldt CJ
  • SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-B.
    Commun Biol Volume: 5 Page(s): 45
    01/12/2022 Authors: Neufeldt CJ; Cerikan B; Cortese M; Frankish J; Lee J-Y; Plociennikowska A; Heigwer F; Prasad V; Joecks S; Burkart SS
  • Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation.
    Nat Commun Volume: 12 Page(s): 7276
    12/14/2021 Authors: Tabata K; Prasad V; Paul D; Lee J-Y; Pham M-T; Twu W-I; Neufeldt CJ; Cortese M; Cerikan B; Stahl Y
  • Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
    J Virol Volume: 95 Page(s): e0131021
    10/13/2021 Authors: Cortese M; Mulder K; Chatel-Chaix L; Scaturro P; Cerikan B; Plaszczyca A; Haselmann U; Bartenschlager M; Neufeldt CJ; Bartenschlager R
  • Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.
    Mol Cell Volume: 81 Page(s): 2851 - 2867.e7
    07/01/2021 Authors: Kamel W; Noerenberg M; Cerikan B; Chen H; Jrvelin AI; Kammoun M; Lee JY; Shuai N; Garcia-Moreno M; Andrejeva A
  • Exploiting a chink in the armor: engineering broadly neutralizing monoclonal antibodies for SARS-like viruses.
    Signal Transduct Target Ther Volume: 6 Page(s): 232
    06/11/2021 Authors: Cortese M; Neufeldt CJ
  • Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
    ACS Infect Dis Volume: 7 Page(s): 1457 - 1468
    06/11/2021 Authors: Steuten K; Kim H; Widen JC; Babin BM; Onguka O; Lovell S; Bolgi O; Cerikan B; Neufeldt CJ; Cortese M
  • Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera: A semi-quantitative, high throughput, microscopy-based assay expands existing approaches to measure SARS-CoV-2 specific antibody levels in human sera.
    Bioessays Volume: 43 Page(s): e2000257
    03/01/2021 Authors: Pape C; Remme R; Wolny A; Olberg S; Wolf S; Cerrone L; Cortese M; Klaus S; Lucic B; Ullrich S
  • A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application to Dengue Virus and SARS-CoV-2.
    J Virol Volume: 95
    01/28/2021 Authors: Pahmeier F; Neufeldt CJ; Cerikan B; Prasad V; Pape C; Laketa V; Ruggieri A; Bartenschlager R; Cortese M
  • Replication-Independent Generation and Morphological Analysis of Flavivirus Replication Organelles.
    STAR Protoc Volume: 1 Page(s): 100173
    12/18/2020 Authors: Goellner S; Cerikan B; Cortese M; Neufeldt CJ; Haselmann U; Bartenschlager R
  • Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.
    Cell Host Microbe Volume: 28 Page(s): 853 - 866.e5
    12/09/2020 Authors: Cortese M; Lee J-Y; Cerikan B; Neufeldt CJ; Oorschot VMJ; Khrer S; Hennies J; Schieber NL; Ronchi P; Mizzon G
  • Structures and distributions of SARS-CoV-2 spike proteins on intact virions.
    Nature Volume: 588 Page(s): 498 - 502
    12/01/2020 Authors: Ke Z; Oton J; Qu K; Cortese M; Zila V; McKeane L; Nakane T; Zivanov J; Neufeldt CJ; Cerikan B
  • SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography.
    Nat Commun Volume: 11 Page(s): 5885
    11/18/2020 Authors: Klein S; Cortese M; Winter SL; Wachsmuth-Melm M; Neufeldt CJ; Cerikan B; Stanifer ML; Boulant S; Bartenschlager R; Chlanda P
  • A Non-Replicative Role of the 3' Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation.
    Cell Rep Volume: 32 Page(s): 107859
    07/07/2020 Authors: Cerikan B; Goellner S; Neufeldt CJ; Haselmann U; Mulder K; Chatel-Chaix L; Cortese M; Bartenschlager R
  • Hepatitis C Virus Replication.
    Cold Spring Harb Perspect Med Volume: 10
    03/02/2020 Authors: Tabata K; Neufeldt CJ; Bartenschlager R
  • ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly.
    Nat Microbiol Volume: 4 Page(s): 2416 - 2429
    12/01/2019 Authors: Neufeldt CJ; Cortese M; Scaturro P; Cerikan B; Wideman JG; Tabata K; Moraes T; Oleksiuk O; Pichlmair A; Bartenschlager R
  • A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.
    PLoS Pathog Volume: 15 Page(s): e1007736
    05/01/2019 Authors: Paszczyca A; Scaturro P; Neufeldt CJ; Cortese M; Cerikan B; Ferla S; Brancale A; Pichlmair A; Bartenschlager R
  • Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum.
    Sci Rep Volume: 8 Page(s): 11685
    08/03/2018 Authors: Steenbergen R; Oti M; Ter Horst R; Tat W; Neufeldt C; Belovodskiy A; Chua TT; Cho WJ; Joyce M; Dutilh BE
  • A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy.
    Viruses Volume: 10
    07/12/2018 Authors: Mnster M; Paszczyca A; Cortese M; Neufeldt CJ; Goellner S; Long G; Bartenschlager R
  • Rewiring cellular networks by members of the Flaviviridae family.
    Nat Rev Microbiol Volume: 16 Page(s): 125 - 142
    02/12/2018 Authors: Neufeldt CJ; Cortese M; Acosta EG; Bartenschlager R
  • Ultrastructural Characterization of Zika Virus Replication Factories.
    Cell Rep Volume: 18 Page(s): 2113 - 2123
    02/28/2017 Authors: Cortese M; Goellner S; Acosta EG; Neufeldt CJ; Oleksiuk O; Lampe M; Haselmann U; Funaya C; Schieber N; Ronchi P
  • Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses.
    Cell Host Microbe Volume: 20 Page(s): 342 - 356
    09/14/2016 Authors: Chatel-Chaix L; Cortese M; Romero-Brey I; Bender S; Neufeldt CJ; Fischl W; Scaturro P; Schieber N; Schwab Y; Fischer B
  • The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.
    PLoS Pathog Volume: 12 Page(s): e1005428
    02/01/2016 Authors: Neufeldt CJ; Joyce MA; Van Buuren N; Levin A; Kirkegaard K; Gale M; Tyrrell DLJ; Wozniak RW
  • Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web.
    PLoS One Volume: 9 Page(s): e114629
    01/01/2014 Authors: Levin A; Neufeldt CJ; Pang D; Wilson K; Loewen-Dobler D; Joyce MA; Wozniak RW; Tyrrell DLJ
  • Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication.
    PLoS Pathog Volume: 9 Page(s): e1003744
    10/01/2013 Authors: Neufeldt CJ; Joyce MA; Levin A; Steenbergen RH; Pang D; Shields J; Tyrrell DLJ; Wozniak RW
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