Chadwick Hales MD, PhD
Academic Appointment
- Assistant Professor, Neurology, Emory University
Education
Degrees
- MD, PhD from Medical College of Georgia
- BS from University of Georgia
Research
Focus
- As a physician scientist who sees patients with cognitive problems in clinic weekly, I am dedicated to advancing our understanding of the basic cellular mechanisms of aging and in neurodegenerative disorders like Alzheimers disease (AD) and frontotemporal dementia. I am also motivated, being personally touched by frontotemporal dementia and having watched my grandfather slowly succumb to the indolent neurodegeneration of AD while my grandmother suffered by his side.
Publications
-
Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease.
Brain Pathol Page(s): e70004
03/23/2025 Authors: Perez SE; Nadeem M; He B; Miguel JC; Moreno DG; Moreno-Rodriguez M; Malek-Ahmadi M; Hales CM; Mufson EJ -
Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.
Psychiatry Clin Neurosci
03/13/2025 Authors: Morrow CB; Kamath V; Dickerson BC; Eldaief M; Rezaii N; Wong B; McGinnis S; Darby R; Staffaroni AM; Lapid MI -
Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.
Mol Neurodegener Volume: 20 Page(s): 30
03/12/2025 Authors: Sheth U; ijerstedt L; Heckman MG; White LJ; Heuer HW; Lario Lago A; Forsberg LK; Faber KM; Foroud TM; Rademakers R -
Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies.
Med Clin North Am Volume: 109 Page(s): 463 - 483
03/01/2025 Authors: Hales CM -
Stratifying risk of Alzheimer's disease in healthy middle-aged individuals with machine learning.
Brain Commun Volume: 7 Page(s): fcaf121
01/01/2025 Authors: Tandon R; Zhao L; Watson CM; Sarkar N; Elmor M; Heilman C; Sanders K; Hales CM; Yang H; Loring DW -
Lower Prevalence of Asymptomatic Alzheimer's Disease Among Healthy African Americans.
Ann Neurol Volume: 96 Page(s): 463 - 475
09/01/2024 Authors: Lah JJ; Tian G; Risk BB; Hanfelt JJ; Wang L; Zhao L; Hales CM; Johnson ECB; Elmor MB; Malakauskas SJ -
Proteomic networks of gray and white matter reveal tissue-specific changes in human tauopathy.
Ann Clin Transl Neurol Volume: 11 Page(s): 2138 - 2152
08/01/2024 Authors: Johnson AG; Dammer EB; Webster JA; Duong DM; Seyfried NT; Hales CM -
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.
Sci Transl Med Volume: 16 Page(s): eadl3758
06/26/2024 Authors: Pluvinage JV; Ngo T; Fouassier C; McDonagh M; Holmes BB; Bartley CM; Kondapavulur S; Hurabielle C; Bodansky A; Pai V -
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology.
Neuron Volume: 112 Page(s): 1110 - 1116.e5
04/03/2024 Authors: Chemparathy A; Le Guen Y; Chen S; Lee E-G; Leong L; Gorzynski JE; Jensen TD; Ferrasse A; Xu G; Xiang H -
Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism.
Sci Rep Volume: 13 Page(s): 13752
08/23/2023 Authors: Borkowski K; Seyfried NT; Arnold M; Lah JJ; Levey AI; Hales CM; Dammer EB; Blach C; Louie G; Kaddurah-Daouk R