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Profile

Craig Coopersmith MD/FACS/FCCM

  • Department of Surgery
    Professor
  • (404) 727-4273
  • cmcoop3@emory.edu
Head shot of Craig Coopersmith

Overview

An eminent academic surgeon in the area of surgical critical care, Dr. Craig Coopersmith is vice chair of research of the Emory Department of Surgery, program director of the department's Surgical Critical Care Fellowship, and director of the Emory Critical Care Center (he served as associate director of the ECCC from 2009-2018). The ECCC is a national leader in designing, testing, and implementing innovations in critical care.

Dr. Coopersmith has established himself as one of the top investigators of sepsis and shock in the country, and was a member of an international task force of experts that redefined the terms "sepsis" and "septic shock" in 2016. The resulting publication in the Journal of the American Medical Association was named one of the journal's Top Articles of the Decade. His current research activity includes an NIH T32 training grant and three NIH R01 grants, two of which are collaborative studies with Emory transplant immunologist Dr. Mandy Ford that are investigating aspects of the immunological host response in sepsis.

Dr. Coopersmith served as president of the Society of Critical Care Medicine from 2015-2016 and is a member of the American Society for Clinical Investigation, which requires its members to have an outstanding record of scholarly achievement in biomedical research. In 2020 he was inducted as a Master of Critical Care Medicine (MCCM) of the American College of Critical Care Medicine (ACCM), considered the highest designation one can have in critical care.

Academic Appointment

  • Vice Chair of Research, Department of Surgery, Emory University School of Medicine
  • Professor of Surgery, Emory University School of Medicine

Education

Degrees

  • MD from University of Pennsylvania School of Medicine
  • BA from University of Pennsylvania

Research

Focus

  • My basic science focus is gut epithelial apoptosis in sepsis and host response in sepsis. My clinical focus is on quality improvement including but not limited to CLABSI, prevention of nosocomial infections, protocolizing/standardizing care, healthcare delivery and staffing in the ICU.

Publications

  • The role of epidermal growth factor in mediating survival in mouse sepsis is dependent upon an intact adaptive immune system.
    Shock
    05/12/2025 Authors: Davis CM; Fitzgerald CA; Jaffree LS; Ali Y; Lee TK; Lyons JD; Mittal R; Liang Z; Martin GS; Suessmuth Y
  • A methodological systematic review of validation and performance of sepsis real-time prediction models.
    NPJ Digit Med Volume: 8 Page(s): 190
    04/07/2025 Authors: Wang Z; Wang W; Sun C; Li J; Xie S; Xu J; Zou K; Jin Y; Yan S; Liao X
  • INTESTINAL EPITHELIAL-SPECIFIC OCCLUDIN DELETION WORSENS GUT PERMEABILITY AND SURVIVAL FOLLOWING SEPSIS.
    Shock Volume: 63 Page(s): 597 - 605
    04/01/2025 Authors: Yumoto T; Oami T; Liang Z; Burd EM; Ford ML; Turner JR; Coopersmith CM
  • Gut integrity in intensive care: alterations in host permeability and the microbiome as potential therapeutic targets.
    J Intensive Care Volume: 13 Page(s): 16
    03/18/2025 Authors: Oami T; Shimazui T; Yumoto T; Otani S; Hayashi Y; Coopersmith CM
  • A review of gut failure as a cause and consequence of critical illness.
    Crit Care Volume: 29 Page(s): 91
    02/26/2025 Authors: Soranno DE; Coopersmith CM; Brinkworth JF; Factora FNF; Muntean JH; Mythen MG; Raphael J; Shaw AD; Vachharajani V; Messer JS
  • Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI).
    Crit Care Volume: 28 Page(s): 420
    12/18/2024 Authors: Bachmann KF; Jenkins B; Asrani V; Bear DE; Bolondi G; Boraso S; Casaer MP; Chang Z; Coopersmith CM; Cotoia A
  • National Institutes of Health COVID-19 Treatment Guidelines Panel: Perspectives and Lessons Learned.
    Ann Intern Med Volume: 177 Page(s): 1547 - 1557
    11/01/2024 Authors: Gulick RM; Pau AK; Daar E; Evans L; Gandhi RT; Tebas P; Ridzon R; Masur H; Lane HC; NIH COVID-19 Treatment Guidelines Panel
  • Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study.
    Crit Care Volume: 28 Page(s): 321
    10/01/2024 Authors: Choudhary T; Upadhyaya P; Davis CM; Yang P; Tallowin S; Lisboa FA; Schobel SA; Coopersmith CM; Elster EA; Buchman TG
  • Response.
    Chest Volume: 166 Page(s): e126
    10/01/2024 Authors: Bhavani SV; Coopersmith CM
  • Association between comorbidities at ICU admission and post-Sepsis physical impairment: A retrospective cohort study.
    J Crit Care Volume: 83 Page(s): 154833
    10/01/2024 Authors: Kobara S; Yamamoto R; Rad MG; Grunwell JR; Hikota N; Uzawa Y; Hayashi Y; Coopersmith CM; Kamaleswaran R
  • The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol.
    JAMA Netw Open Volume: 7 Page(s): e2434197
    09/03/2024 Authors: Bhavani SV; Holder A; Miltz D; Kamaleswaran R; Khan S; Easley K; Murphy DJ; Franks N; Wright DW; Kraft C
  • Disaster management - preparation and planning for acute care facilities.
    Curr Opin Crit Care Volume: 30 Page(s): 195 - 201
    06/01/2024 Authors: Gandra d'Almeida A; Coopersmith CM
  • Nomenclature issues: non-occlusive mesenteric ischaemia and colon ischaemia.
    Intensive Care Med Volume: 50 Page(s): 1013 - 1014
    06/01/2024 Authors: Acosta S; Coopersmith CM; Reintam Blaser A
  • Parsimonious Waveform-derived Features consisting of Pulse Arrival Time and Heart Rate Variability Predicts the Onset of Septic Shock.
    Biomed Signal Process Control Volume: 92
    06/01/2024 Authors: Soliman MM; Marshall C; Kimball JP; Choudhary T; Clermont G; Pinsky MR; Buchman TG; Coopersmith CM; Inan OT; Kamaleswaran R
  • Let's treat the untreatable, but first we need to diagnose it!
    Intensive Care Med Volume: 50 Page(s): 794 - 795
    05/01/2024 Authors: Reintam Blaser A; Coopersmith CM; Acosta S
  • Derivation and Validation of Generalized Sepsis-induced Acute Respiratory Failure Phenotypes Among Critically Ill Patients: A Retrospective Study.
    Res Sq
    04/30/2024 Authors: Choudhary T; Upadhyaya P; Davis CM; Yang P; Tallowin S; Lisboa FA; Schobel SA; Coopersmith CM; Elster EA; Buchman TG
  • Managing acute mesenteric ischaemia.
    Intensive Care Med Volume: 50 Page(s): 593 - 596
    04/01/2024 Authors: Reintam Blaser A; Coopersmith CM; Acosta S
  • Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.
    Proc Natl Acad Sci U S A Volume: 121 Page(s): e2217877121
    03/05/2024 Authors: Oami T; Abtahi S; Shimazui T; Chen C-W; Sweat YY; Liang Z; Burd EM; Farris AB; Roland JT; Tsukita S
  • Using Trajectories of Bedside Vital Signs to Identify COVID-19 Subphenotypes.
    Chest Volume: 165 Page(s): 529 - 539
    03/01/2024 Authors: Bhavani SV; Robichaux C; Verhoef PA; Churpek MM; Coopersmith CM
  • TiME OUT: Time-specific machine-learning evaluation to optimize ultramassive transfusion.
    J Trauma Acute Care Surg Volume: 96 Page(s): 443 - 454
    03/01/2024 Authors: Meyer CH; Nguyen J; ElHabr A; Venkatayogi N; Steed T; Gichoya J; Sciarretta JD; Sikora J; Dente C; Lyons J
  • Surviving Sepsis Campaign Research Priorities 2023.
    Crit Care Med Volume: 52 Page(s): 268 - 296
    02/01/2024 Authors: De Backer D; Deutschman CS; Hellman J; Myatra SN; Ostermann M; Prescott HC; Talmor D; Antonelli M; Pontes Azevedo LC; Bauer SR
  • Transforming the Future of Surgeon-Scientists.
    Ann Surg Volume: 279 Page(s): 231 - 239
    02/01/2024 Authors: Ladner DP; Goldstein AM; Billiar TR; Cameron AM; Carpizo DR; Chu DI; Coopersmith CM; DeMatteo RP; Feng S; Gallagher KA
  • Targeting AMP-activated protein kinase in sepsis.
    Front Endocrinol (Lausanne) Volume: 15 Page(s): 1452993
    01/01/2024 Authors: Yumoto T; Coopersmith CM
  • CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice.
    Front Immunol Volume: 15 Page(s): 1346097
    01/01/2024 Authors: Anyalebechi JC; Sun Y; Davis C; Wagener ME; Liang Z; Burd EM; Coopersmith CM; Ford ML
  • OXIDATIVE study: A pilot prospective observational cohort study protocol examining the influence of peri-reperfusion hyperoxemia and immune dysregulation on early allograft dysfunction after orthotopic liver transplantation.
    PLoS One Volume: 19 Page(s): e0301281
    01/01/2024 Authors: Wilson EA; Woodbury A; Williams KM; Coopersmith CM
  • CTLA-4 Checkpoint Inhibition Improves Sepsis Survival in Alcohol-Exposed Mice.
    Immunohorizons Volume: 8 Page(s): 74 - 88
    01/01/2024 Authors: Paterson CW; Fay KT; Chen C-W; Klingensmith NJ; Gutierrez MB; Liang Z; Coopersmith CM; Ford ML
  • A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis.
    Comp Med Volume: 73 Page(s): 446 - 460
    12/01/2023 Authors: Ferguson LT; Rashied AA; Liang Z; Yumoto T; Anyalebechi JC; Swift DA; Hernandes MS; Krafty RT; Coopersmith CM; Lee VK
  • Vitamin C for Patients With COVID-19: More Evidence of Lack of Efficacy in Patients With Sepsis.
    JAMA Volume: 330 Page(s): 1739 - 1741
    11/14/2023 Authors: Jabaley CS; Coopersmith CM
  • Intravenous vitamin C therapy in adult patients with sepsis: A rapid practice guideline.
    Acta Anaesthesiol Scand Volume: 67 Page(s): 1423 - 1431
    11/01/2023 Authors: Reintam Blaser A; Alhazzani W; Belley-Cote E; Mller MH; Adhikari NKJ; Burry L; Coopersmith CM; Al Duhailib Z; Fujii T; Granholm A
  • Flow-Sizing Critical Care Resources.
    Crit Care Med Volume: 51 Page(s): 1552 - 1565
    11/01/2023 Authors: Nates JL; Oropello JM; Badjatia N; Beilman G; Coopersmith CM; Halpern NA; Herr DL; Jacobi J; Kahn R; Leung S
  • Uncertainty-Aware Convolutional Neural Network for Identifying Bilateral Opacities on Chest X-rays: A Tool to Aid Diagnosis of Acute Respiratory Distress Syndrome.
    Bioengineering (Basel) Volume: 10
    08/08/2023 Authors: Arora M; Davis CM; Gowda NR; Foster DG; Mondal A; Coopersmith CM; Kamaleswaran R
  • CHRONIC ETHANOL USE WORSENS GUT PERMEABILITY AND ALTERS TIGHT JUNCTION EXPRESSION IN A MURINE SEPSIS MODEL.
    Shock Volume: 60 Page(s): 280 - 290
    08/01/2023 Authors: Oami T; Yumoto T; Shimazui T; Sarmiento S; Klingensmith NJ; Chen C-W; Otani S; Liang Z; Burd EM; Mahdi ZK
  • Cancer and sepsis.
    Clin Sci (Lond) Volume: 137 Page(s): 881 - 893
    06/14/2023 Authors: Williams JC; Ford ML; Coopersmith CM
  • Comparison of time series clustering methods for identifying novel subphenotypes of patients with infection.
    J Am Med Inform Assoc Volume: 30 Page(s): 1158 - 1166
    05/19/2023 Authors: Bhavani SV; Xiong L; Pius A; Semler M; Qian ET; Verhoef PA; Robichaux C; Coopersmith CM; Churpek MM
  • Gut Microbiome in Sepsis.
    Surg Infect (Larchmt) Volume: 24 Page(s): 250 - 257
    04/01/2023 Authors: Klingensmith NJ; Coopersmith CM
  • MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
    Shock Volume: 59 Page(s): 612 - 620
    04/01/2023 Authors: Chihade DB; Smith P; Swift DA; Otani S; Zhang W; Chen C-W; Jeffers LA; Liang Z; Shimazui T; Burd EM
  • Surge Capacity in the COVID-19 Era: a Natural Experiment of Neurocritical Care in General Critical Care.
    Neurocrit Care Volume: 38 Page(s): 320 - 325
    04/01/2023 Authors: Philips S; Shi Y; Coopersmith CM; Samuels OB; Pimentel-Farias C; Mei Y; Sadan O; Akbik F
  • Surgical Science and the Evolution of Critical Care Medicine.
    Crit Care Med Volume: 51 Page(s): 182 - 211
    02/01/2023 Authors: Ferrada P; Cannon JW; Kozar RA; Bulger EM; Sugrue M; Napolitano LM; Tisherman SA; Coopersmith CM; Efron PA; Dries DJ
  • The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia.
    Am J Respir Cell Mol Biol Volume: 68 Page(s): 150 - 160
    02/01/2023 Authors: Lyons JD; Mandal P; Otani S; Chihade DB; Easley KF; Swift DA; Burd EM; Liang Z; Koval M; Mocarski ES
  • The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?
    Crit Care Volume: 27 Page(s): 15
    01/13/2023 Authors: Moreno R; Rhodes A; Piquilloud L; Hernandez G; Takala J; Gershengorn HB; Tavares M; Coopersmith CM; Myatra SN; Singer M
  • Cell death proteins in sepsis: key players and modern therapeutic approaches.
    Front Immunol Volume: 14 Page(s): 1347401
    01/01/2023 Authors: Yang CS; Coopersmith CM; Lyons JD
  • Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets.
    Front Immunol Volume: 14 Page(s): 1142614
    01/01/2023 Authors: Paterson CW; Gutierrez MB; Coopersmith CM; Ford ML
  • Bioenergetic Crisis in ICU-Acquired Weakness Gene Signatures Was Associated With Sepsis-Related Mortality: A Brief Report.
    Crit Care Explor Volume: 4 Page(s): e0818
    12/01/2022 Authors: Kobara S; Rad MG; Grunwell JR; Coopersmith CM; Kamaleswaran R
  • Development and validation of novel sepsis subphenotypes using trajectories of vital signs.
    Intensive Care Med Volume: 48 Page(s): 1582 - 1592
    11/01/2022 Authors: Bhavani SV; Semler M; Qian ET; Verhoef PA; Robichaux C; Churpek MM; Coopersmith CM
  • SWEAT ICU-An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs.
    Crit Care Explor Volume: 4 Page(s): e0774
    10/01/2022 Authors: Agarwal A; Chen J-T; Coopersmith CM; Denson JL; Dickert NW; Ferrante LE; Gershengorn HB; Gosine AD; Hayward BJ; Kaur N
  • Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements in Hospitalized Patients.
    JAMA Volume: 328 Page(s): 885 - 886
    09/06/2022 Authors: Bhavani SV; Wiley Z; Verhoef PA; Coopersmith CM; Ofotokun I
  • Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis.
    JCI Insight Volume: 7
    08/22/2022 Authors: Klingensmith NJ; Fay KT; Swift DA; Bazzano JM; Lyons JD; Chen C-W; Meng M; Ramonell KM; Liang Z; Burd EM
  • Critical Care Response During the COVID-19 Pandemic.
    Crit Care Clin Volume: 38 Page(s): 623 - 637
    07/01/2022 Authors: Rednor S; Eisen LA; Cobb JP; Evans L; Coopersmith CM
  • The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone.
    J Clin Invest Volume: 132
    06/15/2022 Authors: Pal S; Perrien DS; Yumoto T; Faccio R; Stoica A; Adams J; Coopersmith CM; Jones RM; Weitzmann MN; Pacifici R
  • Environmental and Social Determinants of Fever in COVID-19
    Volume: 205
    05/01/2022 Authors: Bhavani S; Edathara N; Lyons PG; Luo Y; Wiley Z; Mao C; Bewley A; Robichaux C; Verhoef PA; Coopersmith C
  • The Coronavirus Disease 2019 Pandemic Impacts Burnout Syndrome Differently Among Multiprofessional Critical Care Clinicians-A Longitudinal Survey Study.
    Crit Care Med Volume: 50 Page(s): 440 - 448
    03/01/2022 Authors: Moll V; Meissen H; Pappas S; Xu K; Rimawi R; Buchman TG; Fisher L; Bakshi V; Zellinger M; Coopersmith CM
  • Trends in ICU Mortality From Coronavirus Disease 2019: A Tale of Three Surges.
    Crit Care Med Volume: 50 Page(s): 245 - 255
    02/01/2022 Authors: Auld SC; Harrington KRV; Adelman MW; Robichaux CJ; Overton EC; Caridi-Scheible M; Coopersmith CM; Murphy DJ; Emory COVID-19 Quality and Clinical Research Collaborative
  • Coronavirus Disease 2019 Temperature Trajectories Correlate With Hyperinflammatory and Hypercoagulable Subphenotypes.
    Crit Care Med Volume: 50 Page(s): 212 - 223
    02/01/2022 Authors: Bhavani SV; Verhoef PA; Maier CL; Robichaux C; Parker WF; Holder A; Kamaleswaran R; Wang MD; Churpek MM; Coopersmith CM
  • SWEAT-ICU: A STUDY OF WORKLOAD AND THE ASSOCIATION OF OUTCOMES IN THE ICU
    Volume: 50 Page(s): 156 - 156
    01/01/2022 Authors: Agarwal A; Barnes T; Chen T; Denson J; Desai K; Ferrante L; Gershengorn H; Gosine A; Hayward B; Kaur N
  • Regionalization of Critical Care in the United States: Current State and Proposed Framework From the Academic Leaders in Critical Care Medicine Task Force of the Society of Critical Care Medicine.
    Crit Care Med Volume: 50 Page(s): 37 - 49
    01/01/2022 Authors: Leung S; Pastores SM; Oropello JM; Lilly CM; Galvagno SM; Badjatia N; Jacobi J; Herr DL; Oliveira JD; Academic Leaders in Critical Care Medicine Task Force of the Society of Critical Care Medicine
  • Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit-Reply.
    JAMA Volume: 326 Page(s): 2532 - 2533
    12/28/2021 Authors: Coopersmith CM; Connor MJ
  • Altered Heart Rate Variability Early in ICU Admission Differentiates Critically Ill Coronavirus Disease 2019 and All-Cause Sepsis Patients.
    Crit Care Explor Volume: 3 Page(s): e0570
    12/01/2021 Authors: Kamaleswaran R; Sadan O; Kandiah P; Li Q; Coopersmith CM; Buchman TG
  • Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19.
    Am J Respir Crit Care Med Volume: 204 Page(s): 1224 - 1227
    11/15/2021 Authors: Bhavani SV; Luo Y; Miller WD; Sanchez-Pinto LN; Han X; Mao C; Sandk B; Peek ME; Coopersmith CM; Michelson KN
  • Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.
    Crit Care Med Volume: 49 Page(s): 1974 - 1982
    11/01/2021 Authors: Evans L; Rhodes A; Alhazzani W; Antonelli M; Coopersmith CM; French C; Machado FR; Mcintyre L; Ostermann M; Prescott HC
  • Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
    Crit Care Med Volume: 49 Page(s): e1063 - e1143
    11/01/2021 Authors: Evans L; Rhodes A; Alhazzani W; Antonelli M; Coopersmith CM; French C; Machado FR; Mcintyre L; Ostermann M; Prescott HC
  • Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
    Intensive Care Med Volume: 47 Page(s): 1181 - 1247
    11/01/2021 Authors: Evans L; Rhodes A; Alhazzani W; Antonelli M; Coopersmith CM; French C; Machado FR; Mcintyre L; Ostermann M; Prescott HC
  • Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.
    Shock Volume: 56 Page(s): 621 - 628
    10/01/2021 Authors: Sun Y; Oami T; Liang Z; Miniet AA; Burd EM; Ford ML; Coopersmith CM
  • Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies.
    Crit Care Explor Volume: 3 Page(s): e0511
    09/01/2021 Authors: Martin-Loeches I; Nunnally ME; Hellman J; Lat I; Martin GS; Jog S; Kesecioglu J; De Backer D; Coopersmith CM
  • Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?
    JAMA
    08/10/2021 Authors: Connor MJ; Coopersmith CM
  • Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.
    Ann Intern Med Volume: 174 Page(s): 1151 - 1158
    08/01/2021 Authors: Kuriakose S; Singh K; Pau AK; Daar E; Gandhi R; Tebas P; Evans L; Gulick RM; Lane HC; Masur H
  • The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.
    Intensive Care Med Exp Volume: 9 Page(s): 34
    07/02/2021 Authors: Nunnally ME; Ferrer R; Martin GS; Martin-Loeches I; Machado FR; De Backer D; Coopersmith CM; Deutschman CS; Surviving Sepsis Campaign Reasearch Committee
  • Temporal Differential Expression of Physiomarkers Predicts Sepsis in Critically Ill Adults.
    Shock Volume: 56 Page(s): 58 - 64
    07/01/2021 Authors: Mohammed A; Van Wyk F; Chinthala LK; Khojandi A; Davis RL; Coopersmith CM; Kamaleswaran R
  • Capacity Strain and Response During Coronavirus Disease 2019: One Size Does Not Fit All, and One Size Does Not Fit One.
    Crit Care Med Volume: 49 Page(s): 1189 - 1192
    07/01/2021 Authors: Harris GH; Coopersmith CM
  • TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy.
    JCI Insight Volume: 6
    06/08/2021 Authors: Zhang W; Anyalebechi JC; Ramonell KM; Chen C-W; Xie J; Liang Z; Chihade DB; Otani S; Coopersmith CM; Ford ML
  • Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.
    Volume: 206 Page(s): 2412 - 2419
    05/15/2021 Authors: Chen C-W; Bennion KB; Swift DA; Morrow KN; Zhang W; Oami T; Coopersmith CM; Ford ML
  • Body Temperature Trajectory Associated with Venous Thromboembolism in COVID-19 Patients
    Volume: 203
    05/01/2021 Authors: Bhavani S; Holder A; Kamaleswaran R; Verhoef PA; Churpek MM; Wang M; Coopersmith C
  • Hospital El Salvador: a novel paradigm of intensive care in response to COVID-19 in central America (vol 9, pg e241, 2021)
    LANCET GLOBAL HEALTH Volume: 9 Page(s): E408 - E408
    04/01/2021 Authors: Bello M; Segura V; Camputaro L; Hoyos W; Maza M; Sandoval X; Serpa M; Coopersmith CM
  • The microbiome and the immune system in critical illness.
    Curr Opin Crit Care Volume: 27 Page(s): 157 - 163
    04/01/2021 Authors: Miniet AA; Grunwell JR; Coopersmith CM
  • The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
    Crit Care Med Volume: 49 Page(s): 623 - 635
    04/01/2021 Authors: Lat I; Coopersmith CM; De Backer D; Research Committee of the Surviving Sepsis Campaign; Members of the Surviving Sepsis Campaign Research Committee contributing to this article are as follows; Co-chair, Atlanta, GA; Co-chair, Brussels, Belgium; Manhasset, NY; Consultant, Seattle, WA; Barcelona, Spain
  • Hospital El Salvador: broader questions remain - Authors' reply.
    Lancet Glob Health Volume: 9 Page(s): e407
    04/01/2021 Authors: Bello M; Segura V; Camputaro L; Hoyos W; Maza M; Sandoval X; Serpa M; Coopersmith CM
  • The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
    Crit Care Med Volume: 49 Page(s): 598 - 622
    04/01/2021 Authors: Coopersmith CM; Antonelli M; Bauer SR; Deutschman CS; Evans LE; Ferrer R; Hellman J; Jog S; Kesecioglu J; Kissoon N
  • Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts.
    JCI Insight Volume: 6
    03/08/2021 Authors: Sun Y; Anyalebechi JC; Sun H; Yumoto T; Xue M; Liu D; Liang Z; Coopersmith CM; Ford ML
  • Hospital El Salvador: a novel paradigm of intensive care in response to COVID-19 in central America.
    Lancet Glob Health Volume: 9 Page(s): e241 - e242
    03/01/2021 Authors: Bello M; Segura V; Camputaro L; Hoyos W; Maza M; Sandoval X; Serpa M; Coopersmith CM
  • Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
    Crit Care Med Volume: 49 Page(s): e219 - e234
    03/01/2021 Authors: Alhazzani W; Evans L; Alshamsi F; Mller MH; Ostermann M; Prescott HC; Arabi YM; Loeb M; Ng Gong M; Fan E
  • The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients.
    Intensive Care Med Exp Volume: 9 Page(s): 10
    03/01/2021 Authors: Lat I; Coopersmith CM; De Backer D; Coopersmith CM; Research Committee of the Surviving Sepsis Campaign
  • Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
    JAMA Volume: 325 Page(s): 742 - 750
    02/23/2021 Authors: Sevransky JE; Rothman RE; Hager DN; Bernard GR; Brown SM; Buchman TG; Busse LW; Coopersmith CM; DeWilde C; Ely EW
  • The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis.
    iScience Volume: 24 Page(s): 102093
    02/19/2021 Authors: Morrow KN; Liang Z; Xue M; Chihade DB; Sun Y; Chen C-W; Coopersmith CM; Ford ML
  • Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells.
    Volume: 131
    02/15/2021 Authors: Yu M; Pal S; Paterson CW; Li J-Y; Tyagi AM; Adams J; Coopersmith CM; Weitzmann MN; Pacifici R
  • Measurement of Intestinal Permeability During Sepsis.
    Methods Mol Biol Volume: 2321 Page(s): 169 - 175
    01/01/2021 Authors: Oami T; Coopersmith CM
  • Integrated evaluation of lung disease in single animals.
    PLoS One Volume: 16 Page(s): e0246270
    01/01/2021 Authors: Mandal P; Lyons JD; Burd EM; Koval M; Mocarski ES; Coopersmith CM
  • Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel.
    Ann Intern Med Volume: 174 Page(s): 93 - 95
    01/01/2021 Authors: Pau AK; Aberg J; Baker J; Belperio PS; Coopersmith C; Crew P; Grund B; Gulick RM; Harrison C; Kim A
  • CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells.
    J Immunol Volume: 205 Page(s): 3358 - 3371
    12/15/2020 Authors: Sun Y; Xie J; Anyalebechi JC; Chen C-W; Sun H; Xue M; Liang Z; Morrow KN; Coopersmith CM; Ford ML
  • Declines in Mortality Over Time for Critically Ill Adults With Coronavirus Disease 2019.
    Crit Care Med Volume: 48 Page(s): e1382 - e1384
    12/01/2020 Authors: Auld SC; Caridi-Scheible M; Robichaux C; Coopersmith CM; Murphy DJ; Emory COVID-19 Quality and Clinical Research Collaborative
  • Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.
    Crit Care Med Volume: 48 Page(s): 1645 - 1653
    11/01/2020 Authors: Bhavani SV; Wolfe KS; Hrusch CL; Greenberg JA; Krishack PA; Lin J; Lecompte-Osorio P; Carey KA; Kress JP; Coopersmith CM
  • Workforce, Workload, and Burnout in Critical Care Organizations: Survey Results and Research Agenda.
    Crit Care Med Volume: 48 Page(s): 1565 - 1571
    11/01/2020 Authors: Lilly CM; Oropello JM; Pastores SM; Coopersmith CM; Khan RA; Sessler CN; Christman JW; Academic Leaders in Critical Care Medicine Task Force of the Society of Critical Care Medicine
  • ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019.
    Crit Care Med Volume: 48 Page(s): e799 - e804
    09/01/2020 Authors: Auld SC; Caridi-Scheible M; Blum JM; Robichaux C; Kraft C; Jacob JT; Jabaley CS; Carpenter D; Kaplow R; Hernandez-Romieu AC
  • Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Dysfunction via Altering Tight Junction Protein Expression.
    Shock Volume: 54 Page(s): 330 - 336
    09/01/2020 Authors: Otani S; Oami T; Yoseph BP; Klingensmith NJ; Chen C-W; Liang Z; Coopersmith CM
  • The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities.
    Crit Care Med Volume: 48 Page(s): 1217 - 1232
    08/01/2020 Authors: Deutschman CS; Hellman J; Ferrer Roca R; De Backer D; Coopersmith CM; Research Committee of the Surviving Sepsis Campaign
  • Dexmedetomidine and Cognitive Dysfunction after Critical Illness: What Can (and Cannot) Be Extrapolated from Rodent Models.
    Anesthesiology Volume: 133 Page(s): 258 - 261
    08/01/2020 Authors: Paterson CW; Coopersmith CM
  • The surviving sepsis campaign: basic/translational science research priorities.
    Intensive Care Med Exp Volume: 8 Page(s): 31
    07/17/2020 Authors: Deutschman CS; Hellman J; Roca RF; De Backer D; Coopersmith CM; Research Committee of the Surviving Sepsis Campaign
  • Dexmedetomidine and Cognitive Dysfunction after Critical Illness: What Can (and Cannot) Be Extrapolated from Rodent Models.
    Anesthesiology
    06/18/2020 Authors: Paterson CW; Coopersmith CM
  • ANTI-CTLA-4-INDUCED SURVIVAL INCREASE IN A MURINE MODEL OF SEPSIS FOLLOWING CHRONIC ALCOHOL EXPOSURE IS ASSOCIATED WITH EFFECTOR T-REG GENERATION
    Volume: 53 Page(s): 22 - 22
    06/01/2020 Authors: Paterson C; Ford M; Coopersmith CM
  • IL-27 SIGNALING IS ASSOCIATED WITH INCREASED LAG-3 EXPRESSION ON CD4(+) T CELLS IN SEPSIS
    Volume: 53 Page(s): 107 - 107
    06/01/2020 Authors: Morrow K; Liang Z; Xue M; Chihade D; Sun Y; Chen C-W; Coopersmith CM; Ford M
  • BLOCKADE OF 2B4 IMPAIRS ANTI-TIGIT-INDUCED SURVIVAL IMPROVEMENT IN CANCER SEPSIS
    Volume: 53 Page(s): 48 - 48
    06/01/2020 Authors: Xue M; Sun Y; Morrow K; Liang Z; Coopersmith CM; Ford M
  • CLAUDIN 4 DELETION ALTERS TIGHT JUNCTION PROTEINS BUT DOES NOT CHANGE GUT PERMEABILITY FOLLOWING PNEUMONIA-INDUCED SEPSIS IN MICE
    Volume: 53 Page(s): 54 - 54
    06/01/2020 Authors: Yumoto T; Oami T; Liang Z; Coopersmith CM
  • CHRONIC ALCOHOL USE INCREASES GUT PERMEABILITY AND ALTERS EXPRESSION OF TIGHT JUNCTION PROTEINS AND CYTOKINE PRODUCTION IN A MURINE SEPSIS MODEL
    Volume: 53 Page(s): 73 - 73
    06/01/2020 Authors: Oami T; Chen C-W; Liang Z; Coopersmith CM
  • CLAUDIN-2 DELETION INDUCES OPPOSING EFFECTS ON GUT AND LUNG BARRIER FUNCTION IN PSEUDOMONAS AERUGINOSA PNEUMONIA-INDUCED SEPSIS
    Volume: 53 Page(s): 73 - 74
    06/01/2020 Authors: Oami T; Liang Z; Coopersmith CM
  • ICU and ventilator mortality among critically ill adults with COVID-19.
    medRxiv
    04/26/2020 Authors: Auld SC; Caridi-Scheible M; Blum JM; Robichaux C; Kraft C; Jacob JT; Jabaley CS; Carpenter D; Kaplow R; Hernandez-Romieu AC
  • Breaking the bond between tetranectin and HMGB1 in sepsis.
    Sci Transl Med Volume: 12
    04/15/2020 Authors: Paterson CW; Ford ML; Coopersmith CM
  • Preexisting malignancy abrogates the beneficial effects of CXCR4 blockade during sepsis.
    J Leukoc Biol Volume: 107 Page(s): 485 - 495
    03/01/2020 Authors: Zhang W; Chihade DB; Xie J; Chen C-W; Ramonell KM; Liang Z; Coopersmith CM; Ford ML
  • Correction: Chronic Alcohol Ingestion Increases Mortality and Organ Injury in a Murine Model of Septic Peritonitis.
    PLoS One Volume: 15 Page(s): e0239568
    01/01/2020 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
  • BOOTSTRAP FOREST MODEL PREDICTS NEUROSTIMULANT THERAPY AFTER SEVERE TRAUMATIC BRAIN INJURY
    Volume: 48
    01/01/2020 Authors: Tracy B; Coopersmith C; Silverman M; Fassler M; McCarty E; Gelbard R
  • 2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy.
    JCI Insight Volume: 4
    11/14/2019 Authors: Chen C-W; Xue M; Zhang W; Xie J; Coopersmith CM; Ford ML
  • The gut microbiome alters immunophenotype and survival from sepsis.
    FASEB J Volume: 33 Page(s): 11258 - 11269
    10/01/2019 Authors: Fay KT; Klingensmith NJ; Chen C-W; Zhang W; Sun Y; Morrow KN; Liang Z; Burd EM; Ford ML; Coopersmith CM
  • Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.
    Intensive Care Med Volume: 45 Page(s): 1360 - 1371
    10/01/2019 Authors: Hotchkiss RS; Colston E; Yende S; Crouser ED; Martin GS; Albertson T; Bartz RR; Brakenridge SC; Delano MJ; Park PK
  • Metabolic support in the critically ill: a consensus of 19.
    Crit Care Volume: 23 Page(s): 318
    09/18/2019 Authors: Wernerman J; Christopher KB; Annane D; Casaer MP; Coopersmith CM; Deane AM; De Waele E; Elke G; Ichai C; Karvellas CJ
  • The authors reply.
    Crit Care Med Volume: 47 Page(s): e788 - e789
    09/01/2019 Authors: Hotchkiss RS; Yende S; Angus DC; Moldawer LL; Crouser E; Martin G; Coopersmith CM; Brakenridge S; Mayr FB; Park PK
  • Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
    Alcohol Volume: 77 Page(s): 11 - 18
    06/01/2019 Authors: Kuprys PV; Tsukamoto H; Gao B; Jia L; McGowan J; Coopersmith CM; Moreno MC; Hulsebus H; Meena AS; Souza-Smith FM
  • CLAUDIN-2 DELETION IMPROVES GUT PERMEABILITY AND DECREASES MORTALITY IN MURINE SEPSIS
    Volume: 51 Page(s): 52 - 53
    06/01/2019 Authors: Oami T; Liang Z; Chen C-W; Turner JR; Coopersmith CM
  • ANTI-CD28 ANTIBODY IMPROVES SURVIVAL IN "MEMORY MICE'' WITH SEPSIS VIA IL-10 RELEASED BY REGULATORY T CELLS
    Volume: 51 Page(s): 122 - 122
    06/01/2019 Authors: Sun Y; Chen C-W; Liang Z; Zhang W; Coopersmith CM; Ford ML
  • Murine Pancreatic Cancer Alters T Cell Activation and Apoptosis and Worsens Survival After Cecal Ligation and Puncture.
    Shock Volume: 51 Page(s): 731 - 739
    06/01/2019 Authors: Lyons JD; Chen C-W; Liang Z; Zhang W; Chihade DB; Burd EM; Farris AB; Ford ML; Coopersmith CM
  • RIPK3 NON-KINASE FUNCTION ACTIVATES NFKB TO DRIVE CYTOKINE PRODUCTION AND MORTALITY FOLLOWING PSEUDOMONAS AERUGINOSA PNEUMONIA
    Volume: 51 Page(s): 148 - 149
    06/01/2019 Authors: Lyons J; Mandal P; Chihade D; Koehler H; Otani S; Burd E; Liang Z; Mocarski E; Coopersmith C
  • MYOSIN LIGHT CHAIN KINASE (MLCK) KNOCKOUT MICE PARADOXICALLY DEMONSTRATE INCREASED MORTALITY IN PSEUDOMONAS PNEUMONIA-INDUCED SEPSIS
    Volume: 51 Page(s): 51 - 51
    06/01/2019 Authors: Chihade DB; Smith P; Otani S; Zhang W; Chen C-W; Jeffers L; Liang Z; Burd EM; Farris AB; Koval M
  • MECHANISMS UNDERLYING DECREASED MORTALITY WITH CTLA-4 CHECKPOINT INHIBITION IN A MODEL OF MURINE SEPSIS WITH PREMORBID CHRONIC ALCOHOL EXPOSURE
    Volume: 51 Page(s): 23 - 24
    06/01/2019 Authors: Paterson LTCW; Coopersmith CM; Ford ML
  • IMPACT OF IL-27 SIGNALING IN MEMORY T CELLS ON SEPSIS PATHOPHYSIOLOGY
    Volume: 51 Page(s): 99 - 99
    06/01/2019 Authors: Morrow KN; Chen C-W; Sun Y; Xie J; Chihade DB; Coopersmith CM; Ford ML
  • Increased attrition of memory T cells during sepsis requires 2B4.
    JCI Insight Volume: 4
    05/02/2019 Authors: Xie J; Chen C-W; Sun Y; Laurie SJ; Zhang W; Otani S; Martin GS; Coopersmith CM; Ford ML
  • Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).
    Crit Care Med Volume: 47 Page(s): 632 - 642
    05/01/2019 Authors: Hotchkiss RS; Colston E; Yende S; Angus DC; Moldawer LL; Crouser ED; Martin GS; Coopersmith CM; Brakenridge S; Mayr FB
  • Critical illness and the role of the microbiome.
    Acute Med Surg Volume: 6 Page(s): 91 - 94
    04/01/2019 Authors: Otani S; Chihade DB; Coopersmith CM
  • A venomous relationship: Inflammation, the gut barrier and the STING pathway.
    EBioMedicine Volume: 42 Page(s): 36 - 37
    04/01/2019 Authors: Oami T; Coopersmith CM
  • Can We Compare Sepsis Outcomes on a Hospital Level If Documentation Is Variable (or Inaccurate)?
    Crit Care Med Volume: 47 Page(s): 599 - 600
    04/01/2019 Authors: Hurst SD; Coopersmith CM
  • The microbiome and nutrition in critical illness.
    Curr Opin Crit Care Volume: 25 Page(s): 145 - 149
    04/01/2019 Authors: Oami T; Chihade DB; Coopersmith CM
  • Workforce, Workload, and Burnout Among Intensivists and Advanced Practice Providers: A Narrative Review.
    Crit Care Med Volume: 47 Page(s): 550 - 557
    04/01/2019 Authors: Pastores SM; Kvetan V; Coopersmith CM; Farmer JC; Sessler C; Christman JW; D'Agostino R; Diaz-Gomez J; Gregg SR; Khan RA
  • Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
    Shock Volume: 51 Page(s): 453 - 463
    04/01/2019 Authors: Klingensmith NJ; Fay KT; Lyons JD; Chen C-W; Otani S; Liang Z; Chihade DB; Burd EM; Ford ML; Coopersmith CM
  • Sepsis erodes CD8+ memory Tcell-protective immunity against an EBV homolog in a 2B4-dependent manner.
    Volume: 105 Page(s): 565 - 575
    03/01/2019 Authors: Xie J; Crepeau RL; Chen C-W; Zhang W; Otani S; Coopersmith CM; Ford ML
  • IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis.
    Front Immunol Volume: 10 Page(s): 1982
    01/01/2019 Authors: Morrow KN; Coopersmith CM; Ford ML
  • Gut integrity in critical illness.
    J Intensive Care Volume: 7 Page(s): 17
    01/01/2019 Authors: Otani S; Coopersmith CM
  • Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints.
    Shock Volume: 51 Page(s): 10 - 22
    01/01/2019 Authors: Zingarelli B; Coopersmith CM; Drechsler S; Efron P; Marshall JC; Moldawer L; Wiersinga WJ; Xiao X; Osuchowski MF; Thiemermann C
  • Regulators of Intestinal Epithelial Migration in Sepsis.
    Shock Volume: 51 Page(s): 88 - 96
    01/01/2019 Authors: Meng M; Klingensmith NJ; Liang Z; Lyons JD; Fay KT; Chen C-W; Ford ML; Coopersmith CM
  • Premise for Standardized Sepsis Models.
    Shock Volume: 51 Page(s): 4 - 9
    01/01/2019 Authors: Remick DG; Ayala A; Chaudry IH; Coopersmith CM; Deutschman C; Hellman J; Moldawer L; Osuchowski MF
  • Conflicts of interest disclosure forms and management in critical care clinical practice guidelines.
    Intensive Care Med Volume: 44 Page(s): 1691 - 1698
    10/01/2018 Authors: Alhazzani W; Lewis K; Jaeschke R; Rochwerg B; Mller MH; Evans L; Wilson KC; Patel S; Coopersmith CM; Cecconi M
  • Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
    Infection Volume: 46 Page(s): 745 - 747
    10/01/2018 Authors: Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S
  • It Was the Best of Rounds, It Was the Worst of Rounds, It Was the Age of Wisdom, It Was the Age of Electronic Health Records.
    Crit Care Med Volume: 46 Page(s): 1685 - 1686
    10/01/2018 Authors: Sen A; Coopersmith CM; Herasevich V; Farmer JC
  • Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
    Infection Volume: 46 Page(s): 687 - 691
    10/01/2018 Authors: Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S
  • Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.
    Shock Volume: 50 Page(s): 377 - 380
    10/01/2018 Authors: Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman CS; Drechsler S
  • Professional medical societies: do we have any conflict of interest with industry?
    Intensive Care Med Volume: 44 Page(s): 1762 - 1764
    10/01/2018 Authors: Antonelli M; Coopersmith CM
  • Surviving sepsis campaign: research priorities for sepsis and septic shock.
    Intensive Care Med Volume: 44 Page(s): 1400 - 1426
    09/01/2018 Authors: Coopersmith CM; De Backer D; Deutschman CS; Ferrer R; Lat I; Machado FR; Martin GS; Martin-Loeches I; Nunnally ME; Antonelli M
  • The small heat shock protein HSPB1 protects mice from sepsis.
    Sci Rep Volume: 8 Page(s): 12493
    08/21/2018 Authors: Breed ER; Hilliard CA; Yoseph B; Mittal R; Liang Z; Chen C-W; Burd EM; Brewster LP; Hansen LM; Gleason RL
  • Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
    Intensive Care Med Exp Volume: 6 Page(s): 26
    08/14/2018 Authors: Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S
  • Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
    Shock Volume: 50 Page(s): 178 - 186
    08/01/2018 Authors: Klingensmith NJ; Chen C-W; Liang Z; Burd EM; Farris AB; Arbiser JL; Ford ML; Coopersmith CM
  • Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock.
    Crit Care Med Volume: 46 Page(s): 1334 - 1356
    08/01/2018 Authors: Coopersmith CM; De Backer D; Deutschman CS; Ferrer R; Lat I; Machado FR; Martin GS; Martin-Loeches I; Nunnally ME; Antonelli M
  • Dying as a Pathway to Death in Sepsis.
    Anesthesiology Volume: 129 Page(s): 238 - 240
    08/01/2018 Authors: Zhang W; Coopersmith CM
  • Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
    Immunity Volume: 49 Page(s): 42 - 55.e6
    07/17/2018 Authors: Mandal P; Feng Y; Lyons JD; Berger SB; Otani S; DeLaney A; Tharp GK; Maner-Smith K; Burd EM; Schaeffer M
  • RIP3 KINASE INHIBITION WORSENS MORTALITY IN SEPSIS BY INDUCING CELLULAR APOPTOSIS, AN EFFECT WHICH IS REVERSED FOLLOWING TNF BLOCKADE
    Volume: 49 Page(s): 67 - 67
    06/01/2018 Authors: Fitzgerald CA; Lyons JD; Otani S; Mandal P; Ford ML; Mocarski EW; Coopersmith CM
  • SEPSIS DIFFERENTIALLY IMPACTS TUMOR-SPECIFIC VS. BYSTANDER T CELLS IN MICE WITH PRE-EXISTING MALIGNANCY
    Volume: 49 Page(s): 21 - 21
    06/01/2018 Authors: Chen C-W; Coopersmith C; Ford M
  • MYOSIN LIGHT CHAIN KINASE (MLCK) KNOCKOUT INCREASES MORTALITY IN MICE DURING PSEUDOMONAS PNEUMONIA-INDUCED SEPSIS
    Volume: 49 Page(s): 101 - 101
    06/01/2018 Authors: Chihade DB; Otani S; Zhang W; Liang Z; Burd EM; Coopersmith CM
  • PREVENTION OF INTESTINAL APOPTOSIS IN SEPSIS LEADS TO IMPROVED BARRIER FUNCTION VIA ALTERED TIGHT JUNCTION EXPRESSION
    Volume: 49 Page(s): 106 - 106
    06/01/2018 Authors: Otani S; Joseph BP; Klingensmith NJ; Chen C-W; Chihade DB; Liang Z; Coopersmith CM
  • TIGIT MODULATES SEPSIS-INDUCED DYSREGULATION IN HOSTS WITH PRE-EXISTING MALIGNANCY
    Volume: 49 Page(s): 20 - 21
    06/01/2018 Authors: Zhang W; Ramonell K; Chen C-W; Liang Z; Chihade DB; Otani S; Coopersmith CM; Ford ML
  • Critical Care Organizations: Building and Integrating Academic Programs.
    Crit Care Med Volume: 46 Page(s): e334 - e341
    04/01/2018 Authors: Moore JE; Oropello JM; Stoltzfus D; Masur H; Coopersmith CM; Nates J; Doig C; Christman J; Hite RD; Angus DC
  • Pre-existing malignancy results in increased prevalence of distinct populations of CD4+ T cells during sepsis.
    PLoS One Volume: 13 Page(s): e0191065
    01/01/2018 Authors: Xie J; Robertson JM; Chen C-W; Zhang W; Coopersmith CM; Ford ML
  • RACIAL DIFFERENCES IN THE IMPACT OF DIABETES AND GLYCEMIC CONTROL ON MORTALITY IN ICU PATIENTS
    Volume: 46 Page(s): 204 - 204
    01/01/2018 Authors: Carpenter D; Xu K; Gregg S; Coopersmith C
  • Increased mortality in CD43-deficient mice during sepsis.
    PLoS One Volume: 13 Page(s): e0202656
    01/01/2018 Authors: Fay KT; Chihade DB; Chen C-W; Klingensmith NJ; Lyons JD; Ramonell K; Liang Z; Coopersmith CM; Ford ML
  • Critical Care Organizations: Business of Critical Care and Value/Performance Building.
    Crit Care Med Volume: 46 Page(s): 1 - 11
    01/01/2018 Authors: Leung S; Gregg SR; Coopersmith CM; Layon AJ; Oropello J; Brown DR; Pastores SM; Kvetan V; Academic Leaders in Critical Care Medicine Task Force of the Society of the Critical Care Medicine
  • Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle.
    FASEB J Volume: 31 Page(s): 5507 - 5519
    12/01/2017 Authors: Lyons JD; Klingensmith NJ; Otani S; Mittal R; Liang Z; Ford ML; Coopersmith CM
  • Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
    Clin Infect Dis Volume: 65 Page(s): 1565 - 1569
    10/16/2017 Authors: Septimus EJ; Coopersmith CM; Whittle J; Hale CP; Fishman NO; Kim TJ
  • Fluid Management in Sepsis-Is There a Golden Hour (or Two)?
    Crit Care Med Volume: 45 Page(s): 1773 - 1775
    10/01/2017 Authors: Nugent KL; Coopersmith CM
  • The intestinal microenvironment in sepsis.
    Biochim Biophys Acta Mol Basis Dis Volume: 1863 Page(s): 2574 - 2583
    10/01/2017 Authors: Fay KT; Ford ML; Coopersmith CM
  • Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis.
    J Immunol Volume: 199 Page(s): 1961 - 1966
    09/15/2017 Authors: Chen C-W; Mittal R; Klingensmith NJ; Burd EM; Terhorst C; Martin GS; Coopersmith CM; Ford ML
  • Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
    Mol Med Volume: 23 Page(s): 155 - 165
    08/01/2017 Authors: Lorentz CA; Liang Z; Meng M; Chen C-W; Yoseph BP; Breed ER; Mittal R; Klingensmith NJ; Farris AB; Burd EM
  • Acute Care Nurse Practitioners and Physician Assistants in Critical Care: Transforming Education and Practice.
    Crit Care Med Volume: 45 Page(s): 1111 - 1114
    07/01/2017 Authors: Grabenkort WR; Meissen HH; Gregg SR; Coopersmith CM
  • BLOCKADE OF 2B4 BUT NOT PD-1 MEDIATES DECREASED SEPSIS MORTALITY IN ANIMALS WITH PREEXISTING MALIGNANCY
    Volume: 47 Page(s): 12 - 13
    06/01/2017 Authors: Chen C-W; Klingensmith N; Liang Z; Coopersmith C; Ford M
  • RIP3 KNOCKOUT DURING PSEUDOMONAS AERUGINOSA PNEUMONIA DOES NOT IMPACT IFN-beta SIGNALING OR THE INNATE IMMUNE RESPONSE
    Volume: 47 Page(s): 119 - 120
    06/01/2017 Authors: Otani S; Lyons JD; Chen C-W; Klingensmith NJ; Liang Z; Xie J; Coopersmith CM
  • INCREASED EFFICACY OF ANTI-CTLA-4 IN DECREASING SEPSIS MORTALITY IN CHRONIC ETHANOL EXPOSED MICE RELATIVE TO NON-CHRONIC ETHANOL EXPOSED MICE
    Volume: 47 Page(s): 130 - 131
    06/01/2017 Authors: Fay KT; Chen C-W; Klingensmith N; Liang Z; Coopersmith C; Ford ML
  • PRE-EXISTING MALIGNANCY INCREASES THE CO-EXPRESSION OF TIGIT AND PD-1 ON ACTIVATED CD44(HI) CD4(+) T CELLS IN SEPTIC MICE
    Volume: 47 Page(s): 19 - 20
    06/01/2017 Authors: Ramonell KM; Chen C-W; Fay KT; Klingensmith NJ; Lyons JD; Liang Z; Coopersmith CM; Ford ML
  • IMPROVED SURVIVAL IN SEPTIC JAM-A-/- MICE AND INTESTINAL MICROBIOME-IMMUNE INTERACTION
    Volume: 47 Page(s): 21 - 22
    06/01/2017 Authors: Klingensmith NJ; Fay KT; Chen C-W; Lyons JD; Burd E; Liang Z; Ford ML; Coopersmith CM
  • EPIDERMAL GROWTH FACTOR PARADOXICALLY WORSENS SURVIVAL DURING PERITONEAL SEPSIS IN THE SETTING OF PRE-EXISTING MALIGNANCY
    Volume: 47 Page(s): 34 - +
    06/01/2017 Authors: Fitzgerald CA; Fay KT; Chen C-W; Ramonell KM; Liang Z; Klingensmith NJ; Coopersmith CM; Ford ML
  • HONOKIOL TREATMENT INCREASES DENDRITIC CELLS AND ACTIVATED CD4+T CELLS IN MURINE POLYMICROBIAL SEPSIS
    Volume: 47 Page(s): 63 - 63
    06/01/2017 Authors: Liang Z; Klingensmith N; Chen C-W; Burd E; Farris A; Arbiser J; Ford M; Coopersmith C
  • New insights into the gut as the driver of critical illness and organ failure.
    Curr Opin Crit Care Volume: 23 Page(s): 143 - 148
    04/01/2017 Authors: Meng M; Klingensmith NJ; Coopersmith CM
  • Pathophysiology of the Gut and the Microbiome in the Host Response.
    Pediatr Crit Care Med Volume: 18 Page(s): S46 - S49
    03/01/2017 Authors: Lyons JD; Coopersmith CM
  • Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.
    Crit Care Med Volume: 45 Page(s): 486 - 552
    03/01/2017 Authors: Rhodes A; Evans LE; Alhazzani W; Levy MM; Antonelli M; Ferrer R; Kumar A; Sevransky JE; Sprung CL; Nunnally ME
  • Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.
    Intensive Care Med Volume: 43 Page(s): 304 - 377
    03/01/2017 Authors: Rhodes A; Evans LE; Alhazzani W; Levy MM; Antonelli M; Ferrer R; Kumar A; Sevransky JE; Sprung CL; Nunnally ME
  • The New Sepsis Definitions: Implications for the Basic and Translational Research Communities.
    Shock Volume: 47 Page(s): 264 - 268
    03/01/2017 Authors: Coopersmith CM; Deutschman CS
  • Innovative Interdisciplinary Strategies to Address the Intensivist Shortage.
    Crit Care Med Volume: 45 Page(s): 298 - 304
    02/01/2017 Authors: Buchman TG; Coopersmith CM; Meissen HW; Grabenkort WR; Bakshi V; Hiddleson CA; Gregg SR
  • Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion.
    Shock Volume: 47 Page(s): 184 - 192
    02/01/2017 Authors: Klingensmith NJ; Yoseph BP; Liang Z; Lyons JD; Burd EM; Margoles LM; Koval M; Ford ML; Coopersmith CM
  • CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.
    PLoS One Volume: 12 Page(s): e0188882
    01/01/2017 Authors: Ramonell KM; Zhang W; Hadley A; Chen C-W; Fay KT; Lyons JD; Klingensmith NJ; McConnell KW; Coopersmith CM; Ford ML
  • Fecal microbiota transplantation for multiple organ dysfunction syndrome.
    Crit Care Volume: 20 Page(s): 398
    12/19/2016 Authors: Klingensmith NJ; Coopersmith CM
  • 1329: CD43 SIGNALING CONTROLS SURVIVAL, TH2 SKEWING, AND MEMORY T CELL APOPTOSIS DURING SEPSIS.
    Crit Care Med Volume: 44 Page(s): 408
    12/01/2016 Authors: Fay K; Klingensmith N; Lyons J; Ramonell K; Chen C-W; Liang Z; Coopersmith C; Ford M
  • CD43 SIGNALING CONTROLS SURVIVAL, TH2 SKEWING, AND MEMORY T CELL APOPTOSIS DURING SEPSIS
    Volume: 44
    12/01/2016 Authors: Fay K; Klingensmith N; Lyons J; Ramonell K; Chen C-W; Liang Z; Coopersmith C; Ford M
  • Attrition of memory CD8 T cells during sepsis requires LFA-1.
    J Leukoc Biol Volume: 100 Page(s): 1167 - 1180
    11/01/2016 Authors: Serbanescu MA; Ramonell KM; Hadley A; Margoles LM; Mittal R; Lyons JD; Liang Z; Coopersmith CM; Ford ML; McConnell KW
  • GUT EPITHELIAL INTEGRITY IN SEPSIS
    Volume: 46 Page(s): 22 - 22
    10/01/2016 Authors: Coopersmith C
  • Evolution of Sepsis Management: From Early Goal-Directed Therapy to Personalized Care.
    Adv Surg Volume: 50 Page(s): 221 - 234
    09/01/2016 Authors: Head LW; Coopersmith CM
  • Is A Diagnosis of Sepsis Sufficient to Warrant Stress Ulcer Prophylaxis?
    Crit Care Med Volume: 44 Page(s): 1450 - 1452
    07/01/2016 Authors: Gallagher J; Killian AJ; Coopersmith CM
  • Mechanisms of Intestinal Barrier Dysfunction in Sepsis.
    Shock Volume: 46 Page(s): 52 - 59
    07/01/2016 Authors: Yoseph BP; Klingensmith NJ; Liang Z; Breed ER; Burd EM; Mittal R; Dominguez JA; Petrie B; Ford ML; Coopersmith CM
  • ETHANOL-FED MICE HAVE INCREASED INTESTINAL APOPTOSIS AND WORSENED MORTALITY FOLLOWING PSEUDOMONAS AERUGINOSA PNEUMONIA
    Volume: 45 Page(s): 137 - 137
    06/01/2016 Authors: Klingensmith N; Fay K; Lyons JD; Chen C; Liang Z; Meng M; Coopersmith C
  • THE IMPACT OF ALTERED SEPSIS-INDUCED INTESTINAL PROLIFERATION AND APOPTOSIS ON ENTEROCYTE MIGRATION
    Volume: 45 Page(s): 139 - 139
    06/01/2016 Authors: Meng M; Klingensmith N; Liang Z; Lyons JD; Fay K; Chen C; Coopersmith C
  • THE PROTECTIVE ACTIVITY OF EGF FOLLOWING SEPSIS IS DEPENDENT ON CD4+LYMPHOCYTES
    Volume: 45 Page(s): 136 - 136
    06/01/2016 Authors: Liang Z; Lyons JD; Klingensmith N; Chen C; Meng M; Fay K; Coopersmith C
  • RIP3 MEDIATES INFLAMMATION AND MORTALITY IN PSEUDOMONAS AERUGINOSA PNEUMONIA
    Volume: 45 Page(s): 39 - 40
    06/01/2016 Authors: Lyons JD; Mandel P; Chen C; Klingensmith N; Kaiser WJ; Mocarski E; Coopersmith C
  • THE GASTROINTESTINAL TRACT
    Volume: 45 Page(s): 23 - 23
    06/01/2016 Authors: Coopersmith C
  • CXCR4-BLOCKADE DECREASES CD4 T CELL EXPRESSION OF LAG-3 AND 2B4 IN MURINE SEPSIS
    Volume: 45 Page(s): 102 - 102
    06/01/2016 Authors: Ramonell K; Hadley A; Coopersmith C; McConnell K
  • SYSTEMIC EGF ADMINISTRATION IN A MURINE MODEL OF SEPTIC PERITONITIS AND CHRONIC ETHANOL EXPOSURE REDUCES CELLULAR APOPTOSIS IN CD4+T CELL SUBSETS
    Volume: 45 Page(s): 138 - 139
    06/01/2016 Authors: Fay K; Klingensmith N; Coopersmith C; Ford M
  • 2B4-MEDIATED COINHIBITION OF CD4 T CELLS CONTRIBUTES TO MORTALITY IN SEPSIS
    Volume: 45 Page(s): 61 - 62
    06/01/2016 Authors: Chen C; Klingensmith N; Lyons JD; Liang Z; Coopersmith C; Ford M
  • Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
    Volume: 16 Page(s): 506 - 506
    06/01/2016 Authors: Margoles L; Laurie S; Coopersmith C; Ford M
  • The Microbiome in Critical Illness: Firm Conclusions or Bact to Square One?
    Dig Dis Sci Volume: 61 Page(s): 1420 - 1421
    06/01/2016 Authors: Lyons JD; Ford ML; Coopersmith CM
  • Intravenous immunoglobins in sepsis: the potential risk of overinterpreting a well-done meta-analysis.
    Minerva Anestesiol Volume: 82 Page(s): 505 - 507
    05/01/2016 Authors: Leone M; Duclos G; Coopersmith CM
  • Pathophysiology of septic shock: From bench to bedside.
    Presse Med Volume: 45 Page(s): e93 - e98
    04/01/2016 Authors: McConnell KW; Coopersmith CM
  • The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness.
    Crit Care Clin Volume: 32 Page(s): 203 - 212
    04/01/2016 Authors: Klingensmith NJ; Coopersmith CM
  • A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria.
    Crit Care Med Volume: 44 Page(s): e113 - e121
    03/01/2016 Authors: Angus DC; Seymour CW; Coopersmith CM; Deutschman CS; Klompas M; Levy MM; Martin GS; Osborn TM; Rhee C; Watson RS
  • Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.
    Crit Care Med Volume: 44 Page(s): e122 - e130
    03/01/2016 Authors: Seymour CW; Coopersmith CM; Deutschman CS; Gesten F; Klompas M; Levy M; Martin GS; Osborn TM; Rhee C; Warren DK
  • The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
    JAMA Volume: 315 Page(s): 801 - 810
    02/23/2016 Authors: Singer M; Deutschman CS; Seymour CW; Shankar-Hari M; Annane D; Bauer M; Bellomo R; Bernard GR; Chiche J-D; Coopersmith CM
  • Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses.
    J Immunol Volume: 196 Page(s): 1000 - 1012
    02/01/2016 Authors: Liu D; Burd EM; Coopersmith CM; Ford ML
  • Using Incentives to Improve Resource Utilization: A Quasi-Experimental Evaluation of an ICU Quality Improvement Program.
    Crit Care Med Volume: 44 Page(s): 162 - 170
    01/01/2016 Authors: Murphy DJ; Lyu PF; Gregg SR; Martin GS; Hockenberry JM; Coopersmith CM; Sterling M; Buchman TG; Sevransky J
  • Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.
    PLoS One Volume: 11 Page(s): e0165886
    01/01/2016 Authors: Margoles LM; Mittal R; Klingensmith NJ; Lyons JD; Liang Z; Serbanescu MA; Wagener ME; Coopersmith CM; Ford ML
  • Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis.
    PLoS One Volume: 11 Page(s): e0149069
    01/01/2016 Authors: Lyons JD; Mittal R; Fay KT; Chen C-W; Liang Z; Margoles LM; Burd EM; Farris AB; Ford ML; Coopersmith CM
  • Prevalence and Impact of Unknown Diabetes in the ICU.
    Crit Care Med Volume: 43 Page(s): e541 - e550
    12/01/2015 Authors: Carpenter DL; Gregg SR; Xu K; Buchman TG; Coopersmith CM
  • MORTALITY, GLYCEMIC CONTROL AND HEMOGLOBIN A1C (A1C) IN THE ICU
    Volume: 43
    12/01/2015 Authors: Carpenter D; Gregg S; Xu K; Coopersmith C
  • Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial.
    J Am Coll Surg Volume: 221 Page(s): 739 - 747
    09/01/2015 Authors: Bonne S; Mazuski JE; Sona C; Schallom M; Boyle W; Buchman TG; Bochicchio GV; Coopersmith CM; Schuerer DJE
  • The workforce crisis: a functioning solution.
    Am J Respir Crit Care Med Volume: 191 Page(s): 1340 - 1341
    06/01/2015 Authors: Buchman T; Grabenkort R; Coopersmith C; Meissen H; Gregg S
  • INTESTINAL CO-EXPRESSION OF SV40-TAG AND BCL-2 INCREASES GUT APOPTOSIS DURING SEPSIS
    Volume: 43 Page(s): 124 - 124
    06/01/2015 Authors: Lyons J; Liang Z; Margoles L; Klingensmith N; Coopersmith CM
  • TIME DEPENDENT CHANGES OF TIGHT JUNCTIONS ALTER INTESTINAL PERMEABILITY IN ALCOHOL FED MICE WITH SEPTIC PERITONITIS
    Volume: 43 Page(s): 124 - 125
    06/01/2015 Authors: Klingensmith N; Liang Z; Margoles L; Lyons J; Chen C; Coopersmith CM
  • SEPSIS DECREASES THE CRYPT-TO-VILLUS MIGRATION RATE OF INTESTINAL EPITHELIAL CELLS
    Volume: 43 Page(s): 55 - 55
    06/01/2015 Authors: Meng M; Liang Z; Klingensmith N; Lyons J; Margoles L; Chen C; Coopersmith CM
  • CHRONIC ALCOHOL INGESTION DELAYS MEMORY CD8+T CELL ACTIVATION AND EFFECTOR FUNCTION IN SEPSIS
    Volume: 43 Page(s): 87 - 87
    06/01/2015 Authors: Margoles L; Liang Z; Lyons J; Mittal R; Coopersmith CM; Ford ML
  • THE KINETICS AND FUNCTIONAL ROLE OF 2B4 EXPRESSION ON CD8+T CELLS DURING SEPSIS
    Volume: 43 Page(s): 89 - 89
    06/01/2015 Authors: Chen C; Lyons J; Liang Z; Coopersmith CM; Ford ML
  • Clinical and billing review of extracorporeal membrane oxygenation.
    Chest Volume: 147 Page(s): 1697 - 1703
    06/01/2015 Authors: Blum JM; Lynch WR; Coopersmith CM
  • Murine lung cancer induces generalized T-cell exhaustion.
    J Surg Res Volume: 195 Page(s): 541 - 549
    05/15/2015 Authors: Mittal R; Chen C-W; Lyons JD; Margoles LM; Liang Z; Coopersmith CM; Ford ML
  • Society of Critical Care Medicine presidential address-44th annual congress, January 2015, Phoenix, Arizona.
    Crit Care Med Volume: 43 Page(s): 931 - 933
    05/01/2015 Authors: Coopersmith CM
  • 2B4 Expression on Human CD4+Memory T Cells Is Associated With Functional Impairment
    Volume: 15
    05/01/2015 Authors: Chen C; Laurie S; Lyons J; Coopersmith C; Ford M
  • ICU director data: using data to assess value, inform local change, and relate to the external world.
    Chest Volume: 147 Page(s): 1168 - 1178
    04/01/2015 Authors: Murphy DJ; Ogbu OC; Coopersmith CM
  • PHYSICIAN ASSISTANT BILLING AND PROCEDURES IN THE INTENSIVE CARE UNIT
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Carpenter D; Bush B; Watson H; Coopersmith C
  • PHYSICIAN ASSISTANT DEMOGRAPHICS IN THE INTENSIVE CARE UNIT
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Carpenter D; Bush B; Watson H; Coopersmith C
  • ASSESSING KNOWLEDGE AND CONFIDENCE OF THE NURSE PRACTITIONER AND PHYSICIAN ASSISTANT RESIDENT
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Meissen H; Carpenter D; Grabenkort R; Buchman T; Coopersmith C
  • CD4+LYMPHOCYTES MEDIATE THE BENEFICIAL EFFECT OF EGF IN POLYMICROBIAL SEPSIS
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Liang Z; Margoles L; Lyons J; Chen C-W; Coopersmith C
  • CELLULAR LOCATION DICTATES THE PROLIFERATIVE RESPONSE OF INTESTINAL EPITHELIAL CELLS IN SEPSIS
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Lyons J; Liang Z; Margoles L; Coopersmith C
  • CHRONIC ALCOHOL INGESTION AFFECTS CD4 T CELL FUNCTION BUT NOT ACTIVATION IN SEPSIS
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Margoles L; Mittal R; Serbanescu M; Liang Z; Lyons J; Ford M; Coopersmith C
  • Intensivist perceptions of family-centered rounds and its impact on physician comfort, staff involvement, teaching, and efficiency.
    J Crit Care Volume: 29 Page(s): 915 - 918
    12/01/2014 Authors: Ingram TC; Kamat P; Coopersmith CM; Vats A
  • Critical care telemedicine: evolution and state of the art.
    Crit Care Med Volume: 42 Page(s): 2429 - 2436
    11/01/2014 Authors: Lilly CM; Zubrow MT; Kempner KM; Reynolds HN; Subramanian S; Eriksson EA; Jenkins CL; Rincon TA; Kohl BA; Groves RH
  • Getting older can be exhausting.
    Crit Care Volume: 18 Page(s): 465
    07/29/2014 Authors: Mittal R; Ford ML; Coopersmith CM
  • CHRONIC ALCOHOL INGESTION AND T CELL CYTOKINE PRODUCTION IN SEPSIS
    Volume: 41 Page(s): 72 - 73
    06/01/2014 Authors: Margoles L; Mittal R; Lyons J; Liang Z; Serbanescu M; Ford ML; Coopersmith CM
  • 2B4: A POTENTIAL TARGET FOR RESTORING IMMUNE COMPETENCE DURING SEPSIS
    Volume: 41 Page(s): 29 - 29
    06/01/2014 Authors: Mittal R; Wagener M; Liang Z; Lyons JD; Margoles L; Coopersmith CM; Ford ML
  • THE EFFECTS OF INTESTINE-SPECIFIC EPIDERMAL GROWTH FACTOR IN THE ABSENCE OF LYMPHOCYTES AND ITS ROLE IN MODULATING CROSSTALK BETWEEN THE GUT EPITHELIUM AND LYMPHOCYTES IN SEPSIS
    Volume: 41 Page(s): 73 - 73
    06/01/2014 Authors: Ali Y; Liang Z; Lyons J; Mittal R; Coopersmith CM
  • MURINE LUNG CANCER DECREASES SEPSIS SURVIVAL AND WORSENS SEPSIS-INDUCED IMMUNE COMPROMISE
    Volume: 41 Page(s): 78 - 78
    06/01/2014 Authors: Lyons J; Mittal R; Liang Z; Margoles L; Ford ML; Coopersmith CM
  • CHARACTERIZATION OF THE CD8 T CELL RESPONSE IN A MURINE MODEL OF SEPSIS
    Volume: 41 Page(s): 42 - 42
    06/01/2014 Authors: Serbanescu M; Hadley A; Margoles L; Mittal R; Lyons J; Ali Y; Ford ML; Coopersmith CM; McConnell K
  • Redefining the gut as the motor of critical illness.
    Trends Mol Med Volume: 20 Page(s): 214 - 223
    04/01/2014 Authors: Mittal R; Coopersmith CM
  • Daily bathing with chlorhexidine-based soap and the prevention of Staphylococcus aureus transmission and infection.
    Infect Control Hosp Epidemiol Volume: 35 Page(s): 243 - 250
    03/01/2014 Authors: Viray MA; Morley JC; Coopersmith CM; Kollef MH; Fraser VJ; Warren DK
  • Central venous catheter insertion in septic patients admitted from the emergency department: it is all in the timing*.
    Crit Care Med Volume: 42 Page(s): 735 - 736
    03/01/2014 Authors: Mittal R; Coopersmith CM
  • Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.
    PLoS One Volume: 9 Page(s): e101828
    01/01/2014 Authors: Liang Z; Xie Y; Dominguez JA; Breed ER; Yoseph BP; Burd EM; Farris AB; Davidson NO; Coopersmith CM
  • Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy.
    PLoS One Volume: 9 Page(s): e93523
    01/01/2014 Authors: Mittal R; Wagener M; Breed ER; Liang Z; Yoseph BP; Burd EM; Farris AB; Coopersmith CM; Ford ML
  • Inhibition of IKK in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality.
    Crit Care Med Volume: 41 Page(s): e275 - e285
    10/01/2013 Authors: Dominguez JA; Samocha AJ; Liang Z; Burd EM; Farris AB; Coopersmith CM
  • Prescribing patterns of hydrocortisone in septic shock: a single-center experience of how surviving sepsis guidelines are interpreted and translated into bedside practice.
    Crit Care Med Volume: 41 Page(s): 2310 - 2317
    10/01/2013 Authors: Contrael KM; Killian AJ; Gregg SR; Buchman TG; Coopersmith CM
  • Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis.
    Anesthesiology Volume: 119 Page(s): 755 - 756
    10/01/2013 Authors: Kharasch ED; Coopersmith CM
  • Providing care for critically ill surgical patients: challenges and recommendations.
    JAMA Surg Volume: 148 Page(s): 669 - 674
    07/01/2013 Authors: Tisherman SA; Kaplan L; Gracias VH; Beilman GJ; Toevs C; Byrnes MC; Coopersmith CM; Surgery Section, Society of Critical Care Medicine
  • Microfluidic amperometric sensor for analysis of nitric oxide in whole blood.
    Anal Chem Volume: 85 Page(s): 6066 - 6072
    06/18/2013 Authors: Hunter RA; Privett BJ; Henley WH; Breed ER; Liang Z; Mittal R; Yoseph BP; McDunn JE; Burd EM; Coopersmith CM
  • LFA-1 BLOCKADE IMPROVES SURVIVAL IN A MURINE MODEL OF SEPSIS VIA A LYMPHOCYTE-DEPENDENT MECHANISM
    Volume: 39 Page(s): 43 - 44
    06/01/2013 Authors: Serbanescu M; Hadley A; Yoseph BP; Coopersmith C; McConnell K
  • PRE-EXISTING MALIGNANCY ALTERS INNATE AND ADAPTIVE IMMUNE RESPONSES IN A MURINE MODEL OF INFECTION
    Volume: 39 Page(s): 46 - 46
    06/01/2013 Authors: Mittal R; Wagener M; Breed ER; Liang Z; Yoseph BP; Coopersmith C; Ford M
  • CHRONIC ALCOHOL CONSUMPTION INCREASES MORTALITY IN A MURINE MODEL OF SEPSIS AND ALTERS THE HOST IMMUNE RESPONSE
    Volume: 39 Page(s): 106 - 107
    06/01/2013 Authors: Yoseph BP; Liang Z; Breed ER; Mittal R; Wagener M; Ford M; Coopersmith C
  • THE ROLE OF HSP25 IN MEDIATING MORTALITY IN SEPSIS
    Volume: 39 Page(s): 38 - 39
    06/01/2013 Authors: Breed ER; Yoseph BP; Liang Z; Hadley A; Mittal R; Hunt C; Coopersmith C
  • CXCR4 ANTAGONISM PLERIXAFOR IMPROVES SURVIVAL AFTER POLYMICROBIAL SEPSIS
    Volume: 39 Page(s): 69 - 69
    06/01/2013 Authors: Hadley A; Serbanescu M; Yoseph BP; Mittal R; Coopersmith C; McConnell K
  • The turn team: a novel strategy for reducing pressure ulcers in the surgical intensive care unit.
    J Am Coll Surg Volume: 216 Page(s): 373 - 379
    03/01/2013 Authors: Still MD; Cross LC; Dunlap M; Rencher R; Larkins ER; Carpenter DL; Buchman TG; Coopersmith CM
  • A novel concept in residency education: case-based remediation.
    J Emerg Med Volume: 44 Page(s): 493 - 498
    02/01/2013 Authors: Katz ED; Goyal DG; Char D; Coopersmith CM; Fried ED
  • Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.
    PLoS One Volume: 8 Page(s): e62792
    01/01/2013 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
  • Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.
    PLoS One Volume: 8 Page(s): e77203
    01/01/2013 Authors: Jung E; Perrone EE; Brahmamdan P; McDonough JS; Leathersich AM; Dominguez JA; Clark AT; Fox AC; Dunne WM; Hotchkiss RS
  • DIFFERENCE IN LACTATE LEVELS AND CARDIAC FUNCTION AMONG THREE SEPTIC PATIENT GROUPS STRATIFIED BY INITIAL CENTRAL VENOUS OXYGEN SATURATION LEVELS
    Volume: 40 Page(s): U279 - U279
    12/01/2012 Authors: Nakamura M; Coopersmith C; Greg M; Kandiah P; McConnell K; Still M; Nicholls M; Oda S; Hirasawa H; Buchman T
  • ASSOCIATION AMONG INITIAL CENTRAL VENOUS OXYGEN SATURATION LEVELS, INITIAL BLOOD LACTATE LEVELS AND OUTCOME IN SEPTIC PATIENTS TREATED WITH EARLY GOAL-DIRECTED THERAPY
    Volume: 40 Page(s): U174 - U174
    12/01/2012 Authors: Nakamura M; Coopersmith C; Greg M; McConnell K; Kandiah P; Still M; Nicholls M; Oda S; Hirasawa H; Buchman T
  • THE IMPACT OF UNKNOWN DIABETES IN THE ICU
    Volume: 40 Page(s): U89 - U89
    12/01/2012 Authors: Carpenter D; Gregg S; Buchman T; Coopersmith C
  • PRESCRIBING PATTERNS OF INTRAVENOUS HYDROCORTISONE IN SEPTIC SHOCK: FINDINGS FROM AN ACADEMIC HEALTHCARE SYSTEM
    Volume: 40 Page(s): U135 - U136
    12/01/2012 Authors: Contrael K; Killian A; Gregg S; Buchman T; Coopersmith C
  • EFFECTS OF HEMOGLOBIN A1C ON GLYCEMIC CONTROL IN THE ICU
    Volume: 40 Page(s): U91 - U91
    12/01/2012 Authors: Carpenter D; Gregg S; Buchman T; Coopersmith C
  • COMPARISON OF SELF-DESCRIBED AND ACTUAL PRESCRIBING PATTERNS OF HYDROCORTISONE IN SEPTIC SHOCK IN AN ACADEMIC MEDICAL CENTER
    Volume: 40 Page(s): U293 - U293
    12/01/2012 Authors: Killian A; Contrael K; Gregg S; Buchman T; Coopersmith C
  • The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia.
    Shock Volume: 38 Page(s): 508 - 514
    11/01/2012 Authors: Fox AC; McConnell KW; Yoseph BP; Breed E; Liang Z; Clark AT; O'Donnell D; Zee-Cheng B; Jung E; Dominguez JA
  • Differential regulation of tissue thiol-disulfide redox status in a murine model of peritonitis.
    J Inflamm (Lond) Volume: 9 Page(s): 36
    10/04/2012 Authors: Benton SM; Liang Z; Hao L; Liang Y; Hebbar G; Jones DP; Coopersmith CM; Ziegler TR
  • Response patterns of pro-inflammatory and anti-inflammatory cytokines in serum and peritoneal fluid during sepsis
    Volume: 215 Page(s): S50 - S50
    09/01/2012 Authors: Yoseph BP; Breed E; Liang Z; McConnell K; Coopersmith CM
  • Mechanisms of methicillin-resistant Staphylococcus aureus pneumonia-induced intestinal epithelial apoptosis.
    Shock Volume: 38 Page(s): 68 - 75
    07/01/2012 Authors: Perrone EE; Jung E; Breed E; Dominguez JA; Liang Z; Clark AT; Dunne WM; Burd EM; Coopersmith CM
  • Organ failure avoidance and mitigation strategies in surgery.
    Surg Clin North Am Volume: 92 Page(s): 307 - ix
    04/01/2012 Authors: McConnell KW; Coopersmith CM
  • A comparison of critical care research funding and the financial burden of critical illness in the United States.
    Crit Care Med Volume: 40 Page(s): 1072 - 1079
    04/01/2012 Authors: Coopersmith CM; Wunsch H; Fink MP; Linde-Zwirble WT; Olsen KM; Sommers MS; Anand KJS; Tchorz KM; Angus DC; Deutschman CS
  • Patient-care time allocation by nurse practitioners and physician assistants in the intensive care unit.
    Crit Care Volume: 16 Page(s): R27
    02/15/2012 Authors: Carpenter DL; Gregg SR; Owens DS; Buchman TG; Coopersmith CM
  • INTESTINE-SPECIFIC MTTP DELETION INCREASES MORTALITY IN AN AGED MURINE MODEL OF PSEUDOMONAS AERUGINOSA PNEUMONIA
    Volume: 37 Page(s): 61 - 62
    01/01/2012 Authors: Liang Z; Xie Y; Dominguez JA; Breed ER; Yoseph BP; Davidson NO; Coopersmith CM
  • SEPSIS INCREASES INTESTINAL PERMEABILITY BY ALTERING THE TIGHT JUNCTION
    Volume: 37 Page(s): 56 - 57
    01/01/2012 Authors: Yoseph BP; Breed ER; Liang Z; Dominguez J; McConnell K; Coopersmith CM
  • THE PROTECTIVE EFFECT OF EPIDERMAL GROWTH FACTOR DURING SEPSIS DEPENDS ON THE ADAPTIVE IMMUNE SYSTEM
    Volume: 37 Page(s): 23 - 23
    01/01/2012 Authors: Jaffree LS; Liang Z; Breed ER; Coopersmith CM
  • HEAVY WATER MITIGATES SURVIVAL IN SEPTIC MICE
    Volume: 37 Page(s): 62 - 62
    01/01/2012 Authors: Breed ER; Liang Z; Wagener ME; Yoseph BP; Ferrer IR; Ford ML; Buchman TG; Coopersmith CM
  • Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.
    Shock Volume: 37 Page(s): 85 - 94
    01/01/2012 Authors: Jung E; Perrone EE; Liang Z; Breed ER; Dominguez JA; Clark AT; Fox AC; Dunne WM; Burd EM; Farris AB
  • Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia.
    PLoS One Volume: 7 Page(s): e49159
    01/01/2012 Authors: Dominguez JA; Xie Y; Dunne WM; Yoseph BP; Burd EM; Coopersmith CM; Davidson NO
  • Physician and nurse acceptance of technicians to screen for geriatric syndromes in the emergency department.
    West J Emerg Med Volume: 12 Page(s): 489 - 495
    11/01/2011 Authors: Carpenter CR; Griffey RT; Stark S; Coopersmith CM; Gage BF
  • The Accreditation Council for Graduate Medical Education resident duty hour new standards: history, changes, and impact on staffing of intensive care units.
    Crit Care Med Volume: 39 Page(s): 2540 - 2549
    11/01/2011 Authors: Pastores SM; O'Connor MF; Kleinpell RM; Napolitano L; Ward N; Bailey H; Mollenkopf FP; Coopersmith CM
  • Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia.
    Shock Volume: 36 Page(s): 381 - 389
    10/01/2011 Authors: Dominguez JA; Vithayathil PJ; Khailova L; Lawrance CP; Samocha AJ; Jung E; Leathersich AM; Dunne WM; Coopersmith CM
  • Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality.
    J Immunol Volume: 187 Page(s): 1950 - 1956
    08/15/2011 Authors: Fox AC; Breed ER; Liang Z; Clark AT; Zee-Cheng BR; Chang KC; Dominguez JA; Jung E; Dunne WM; Burd EM
  • HEAVY WATER (D2O) SENSITIZES MICE TO CECAL LIGATION AND PUNCTURE (CLP)
    Volume: 35 Page(s): 70 - 70
    06/01/2011 Authors: Liang Z; Breed ER; Buchman TG; Coopersmith CM
  • THE ROLE OF EPIDERMAL GROWTH FACTOR IN MEDIATING AGE-DEPENDENT MORTALITY IN SEPSIS
    Volume: 35 Page(s): 7 - 8
    06/01/2011 Authors: Liang Z; Breed ER; Dominguez JA; Coopersmith CM
  • METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA PNEUMONIA INDUCE INTESTINAL EPITHELIAL APOPTOSIS VIA DISTINCT MECHANISMS
    Volume: 35 Page(s): 66 - 67
    06/01/2011 Authors: Breed ER; Jung E; Liang Z; Perrone EE; Dominguez JA; Dunne WM; Burd EM; Buchman TG; Coopersmith CM
  • The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.
    J Immunol Volume: 186 Page(s): 3718 - 3725
    03/15/2011 Authors: McConnell KW; Fox AC; Clark AT; Chang N-YN; Dominguez JA; Farris AB; Buchman TG; Hunt CR; Coopersmith CM
  • IMPACT OF FAMILY PRESENCE DURING ROUNDS ON PHYSICIAN COMFORT AND PERCEPTION OF TEACHING AND EFFICIENCY
    Volume: 38 Page(s): U225 - U225
    12/01/2010 Authors: Ingram T; Kamat P; Coopersmith C; Vats A
  • DECREASED MORTALITY FOLLOWING EPIDERMAL GROWTH FACTOR TREATMENT IS ASSOCIATED WITH ATTENUATED INTESTINAL INJURY IN PSEUDOMONAS AERUGINOSA PNEUMONIA
    Volume: 38 Page(s): U49 - U49
    12/01/2010 Authors: Dominguez J; Khailova L; Vithayathil P; Lawrance C; Coopersmith C
  • Can we protect the gut in critical illness? The role of growth factors and other novel approaches.
    Crit Care Clin Volume: 26 Page(s): 549 - x
    07/01/2010 Authors: Dominguez JA; Coopersmith CM
  • MECHANISMS THROUGH WHICH GUT BCL-2 OVER-EXPRESSION IMPROVES SURVIVAL IN MICE GIVEN IRRADIATION FOLLOWED BY MRSA PNEUMONIA
    Volume: 33 Page(s): 11 - 11
    06/01/2010 Authors: Jung E; Perrone E; Brahmamdan P; McDonough J; Davis C; Dominguez J; Hotchkiss R; Coopersmith C
  • EPIDERMAL GROWTH FACTOR ATTENUATES GUT INJURY AND DECREASES MORTALITY IN PSEUDOMONAS AERUGINOSA PNEUMONIA-INDUCED SEPSIS
    Volume: 33 Page(s): 3 - 3
    06/01/2010 Authors: Dominguez J; Vithayathil P; Lawrance C; Coopersmith C
  • Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter?
    Infect Control Hosp Epidemiol Volume: 31 Page(s): 584 - 591
    06/01/2010 Authors: Honda H; Krauss MJ; Coopersmith CM; Kollef MH; Richmond AM; Fraser VJ; Warren DK
  • Characterization and modulation of the immunosuppressive phase of sepsis.
    Infect Immun Volume: 78 Page(s): 1582 - 1592
    04/01/2010 Authors: Muenzer JT; Davis CG; Chang K; Schmidt RE; Dunne WM; Coopersmith CM; Hotchkiss RS
  • TNF is a key mediator in sepsis-induced intestinal barrier dysfunction but is independent of enterocyte NF kappa B
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Samocha AJ; Coopersmith CM; Dominguez JA
  • Epidermal growth factor treatment prevents intestinal injury in weanling mice with septic peritonitis
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Dominguez JA; Coopersmith CM
  • Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.
    Crit Care Med Volume: 38 Page(s): 886 - 893
    03/01/2010 Authors: Fox AC; Robertson CM; Belt B; Clark AT; Chang KC; Leathersich AM; Dominguez JA; Perrone EE; Dunne WM; Hotchkiss RS
  • IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.
    J Immunol Volume: 184 Page(s): 1401 - 1409
    02/01/2010 Authors: Inoue S; Unsinger J; Davis CG; Muenzer JT; Ferguson TA; Chang K; Osborne DF; Clark AT; Coopersmith CM; McDunn JE
  • Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses.
    Crit Care Med Volume: 38 Page(s): 223 - 241
    01/01/2010 Authors: McConnell KW; McDunn JE; Clark AT; Dunne WM; Dixon DJ; Turnbull IR; Dipasco PJ; Osberghaus WF; Sherman B; Martin JR
  • IMPACT OF TRANSCRIPTION FACTOR DECOY TO AP-1 ON THE LUNG APOPTOSIS OF SEPTIC MICE
    Volume: 37 Page(s): A425 - A425
    12/01/2009 Authors: Lewis L; Clark J; Coopersmith C; Doe J
  • Examination of non-clinical factors affecting tracheostomy practice in an academic surgical intensive care unit.
    Crit Care Med Volume: 37 Page(s): 3070 - 3078
    12/01/2009 Authors: Freeman BD; Kennedy C; Coopersmith CM; Buchman TG
  • Implementation of a mandatory checklist of protocols and objectives improves compliance with a wide range of evidence-based intensive care unit practices.
    Crit Care Med Volume: 37 Page(s): 2775 - 2781
    10/01/2009 Authors: Byrnes MC; Schuerer DJE; Schallom ME; Sona CS; Mazuski JE; Taylor BE; McKenzie W; Thomas JM; Emerson JS; Nemeth JL
  • Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis.
    Am J Physiol Gastrointest Liver Physiol Volume: 297 Page(s): G471 - G479
    09/01/2009 Authors: Clark JA; Gan H; Samocha AJ; Fox AC; Buchman TG; Coopersmith CM
  • Geriatric Syndrome Screening in Emergency Medicine: A Geriatric Technician Acceptability Analysis
    Volume: 54 Page(s): S82 - S82
    09/01/2009 Authors: Carpenter CR; Griffey RT; Stark S; Coopersmith CM; Gage BF
  • Prevalence and cost of full-time research fellowships during general surgery residency.
    Ann Surg Volume: 250 Page(s): 352
    08/01/2009 Authors: Robertson CM; Klingensmith ME; Coopersmith CM
  • Targeted delivery of siRNA to cell death proteins in sepsis.
    Shock Volume: 32 Page(s): 131 - 139
    08/01/2009 Authors: Brahmamdam P; Watanabe E; Unsinger J; Chang KC; Schierding W; Hoekzema AS; Zhou TT; McDonough JS; Holemon H; Heidel JD
  • CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis.
    FASEB J Volume: 23 Page(s): 1817 - 1825
    06/01/2009 Authors: Stromberg PE; Woolsey CA; Clark AT; Clark JA; Turnbull IR; McConnell KW; Chang KC; Chung C-S; Ayala A; Buchman TG
  • The sepsis seesaw: tilting toward immunosuppression.
    Nat Med Volume: 15 Page(s): 496 - 497
    05/01/2009 Authors: Hotchkiss RS; Coopersmith CM; McDunn JE; Ferguson TA
  • Catheter-related bloodstream infection.
    Surg Clin North Am Volume: 89 Page(s): 463 - ix
    04/01/2009 Authors: Goede MR; Coopersmith CM
  • Inhibition of enterocyte NF kappa B exacerbates intestinal barrier dysfunction in a murine model of sepsis
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Clark JA; Samocha AJ; Coopersmith CM
  • Effects of aging on the immunopathologic response to sepsis.
    Crit Care Med Volume: 37 Page(s): 1018 - 1023
    03/01/2009 Authors: Turnbull IR; Clark AT; Stromberg PE; Dixon DJ; Woolsey CA; Davis CG; Hotchkiss RS; Buchman TG; Coopersmith CM
  • Erythropoietin in sepsis: a new use for a familiar drug?
    Crit Care Med Volume: 37 Page(s): 1138 - 1139
    03/01/2009 Authors: Fox AC; Coopersmith CM
  • Prevalence and cost of full-time research fellowships during general surgery residency: a national survey.
    Ann Surg Volume: 249 Page(s): 155 - 161
    01/01/2009 Authors: Robertson CM; Klingensmith ME; Coopersmith CM
  • The impact of a simple, low-cost oral care protocol on ventilator-associated pneumonia rates in a surgical intensive care unit.
    J Intensive Care Med Volume: 24 Page(s): 54 - 62
    01/01/2009 Authors: Sona CS; Zack JE; Schallom ME; McSweeney M; McMullen K; Thomas J; Coopersmith CM; Boyle WA; Buchman TG; Mazuski JE
  • ANTI-IL10 THERAPY INCREASES SURVIVAL IN A TWO-HIT MODEL OF SEPSIS
    Volume: 31 Page(s): 75 - 75
    01/01/2009 Authors: Muenzer J; Davis C; Chang K; Osborne D; Dunne M; Coopersmith C; Hotchkiss R
  • SEPSIS UNCOUPLES GUT EPITHELIAL PROLIFERATION AND DEATH FROM MIGRATION AND CELL DENSITY IN MICE
    Volume: 31 Page(s): 73 - 73
    01/01/2009 Authors: Clark A; Zee-Cheng B; Dunne W; Buchman T; Hotchkiss R; Coopersmith C
  • SURVIVAL IN A TWO-HIT MODEL OF SEPSIS IS DEPENDENT ON TIMING OF SECONDARY INJURY
    Volume: 31 Page(s): 74 - 75
    01/01/2009 Authors: Davis C; Muenzer J; Chang K; Osborne D; Dunne M; Coopersmith C; Hotchkiss R
  • ANTI-TNF PREVENTS GUT BARRIER DYSFUNCTION IN SEPTIC MICE
    Volume: 31 Page(s): 73 - 74
    01/01/2009 Authors: Clark J; Samocha A; Coopersmith C
  • THE ENDOGENOUS BACTERIA MEDIATE SEPSIS-INDUCED INCREASES IN GUT EPITHELIAL APOPTOSIS
    Volume: 31 Page(s): 12 - 12
    01/01/2009 Authors: Fox A; McConnell K; Clark A; Dunne W; Coopersmith C
  • MECHANISMS OF MRSA PNEUMONIA-INDUCED GUT EPITHELIAL APOPTOSIS
    Volume: 31 Page(s): 75 - 76
    01/01/2009 Authors: Jung E; Perrone E; Clark J; Clark A; Dunne W; Buchman T; Hotchkiss R; Coopersmith C
  • BLOCKING PD-1 INHIBITS LYMPHOCYTE APOPTOSIS DURING SEPSIS.
    Volume: 36 Page(s): A37 - A37
    12/01/2008 Authors: Brahmamdam P; Coopersmith CM; Chang KC; Osborne DF; McDunn JE; Hotchkiss RS
  • CATHETER-RELATED BLOODSTREAM INFECTION RATES IN MINOCYCLINE/RIFAMPIN VS. CHLORHEXIDINE/SILVER SULFADIAZINE-IMPREGNATED CENTRAL VENOUS CATHETERS - RESULTS OF A 46 MONTH STUDY
    Volume: 36 Page(s): A113 - A113
    12/01/2008 Authors: Schuerer DJ; Mazuski JE; Buchman TG; Coopersmith CM; Sona CS; Schallom ME; McMullen K; Doll S; Warren DK; Fraser VJ
  • SITE AND SOURCE OF INFECTION MEDIATE LOCAL AND SYSTEMIC HOST RESPONSE IN SEPTIC MICE.
    Volume: 36 Page(s): A38 - A38
    12/01/2008 Authors: Clark AT; Hotchkiss WR; Zee-Cheng BR; Clark JA; Fox AC; McConnell KW; Dunne WM; Buchman TG; Coopersmith CM
  • Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.
    J Surg Res Volume: 150 Page(s): 278 - 285
    12/01/2008 Authors: Robertson CM; Perrone EE; McConnell KW; Dunne WM; Boody B; Brahmbhatt T; Diacovo MJ; Van Rooijen N; Hogue LA; Cannon CL
  • ENTEROCYTE-SPECIFIC OVEREXPRESSION OF EPIDERMAL GROWTH FACTOR PRESERVES INTESTINAL BARRIER FUNCTION IN SEPSIS.
    Volume: 36 Page(s): A2 - A2
    12/01/2008 Authors: Clark J; Samocha A; Gan H; Coopersmith C
  • INTESTINAL OVEREXPRESSION OF BCL-2 DECREASES GUT EPITHELIAL APOPTOSIS AND IMPROVES SURVIVAL IN MICE SUBJECTED TO WHOLE BODY IRRADIATION FOLLOWED BY MRSA PNEUMONIA.
    Volume: 36 Page(s): A42 - A42
    12/01/2008 Authors: Jung E; Clark JA; Clark AT; Fox AC; Dunne WM; Buchman TG; Coopersmith CM; Brahmamdam P; Davis CG; McDonough JS
  • PREVENTING APOPTOSIS IN SEPTIC MICE WITH CANCER UNEXPECTEDLY INCREASES MORTALITY
    Volume: 36 Page(s): A2 - A2
    12/01/2008 Authors: Fox AC; Clark A; Dunne WM; Linehan D; Coopersmith C
  • Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients.
    Pharmacoepidemiol Drug Saf Volume: 17 Page(s): 971 - 981
    10/01/2008 Authors: Freeman BD; Dixon DJ; Coopersmith CM; Zehnbauer BA; Buchman TG
  • Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age.
    Pediatr Crit Care Med Volume: 9 Page(s): 530 - 535
    09/01/2008 Authors: Checchia PA; Schierding W; Polpitiya A; Dixon D; Macmillan S; Muenzer J; Stromberg P; Coopersmith CM; Buchman TG; Cobb JP
  • siRNA targeted at pro-apoptotic proteins, PUMA and BIM, inhibits sepsis-induced lymphocyte apoptosis
    Volume: 207 Page(s): S34 - S34
    09/01/2008 Authors: Brahmamdam P; Chang KC; Zeidan RK; Rele SM; Liang Y; Liu JY; Heidel JD; McDunn JE; Coopersmith CM; Hotchkiss RS
  • Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.
    Shock Volume: 30 Page(s): 36 - 42
    07/01/2008 Authors: Clark JA; Clark AT; Hotchkiss RS; Buchman TG; Coopersmith CM
  • Extracorporeal membrane oxygenation: current clinical practice, coding, and reimbursement.
    Chest Volume: 134 Page(s): 179 - 184
    07/01/2008 Authors: Schuerer DJE; Kolovos NS; Boyd KV; Coopersmith CM
  • Tracheostomy protocol: experience with development and potential utility.
    Crit Care Med Volume: 36 Page(s): 1742 - 1748
    06/01/2008 Authors: Freeman BD; Kennedy C; Robertson TE; Coopersmith CM; Schallom M; Sona C; Cracchiolo L; Schuerer DJE; Boyle WA; Buchman TG
  • Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.
    Shock Volume: 29 Page(s): 483 - 489
    04/01/2008 Authors: Rajan S; Vyas D; Clark AT; Woolsey CA; Clark JA; Hotchkiss RS; Buchman TG; Coopersmith CM
  • Epidermal growth factor preserves intestinal integrity and decreases mortality in a murine model of Pseudomonas aeruginosa pneumonia
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Clark JA; Lawrance CP; Dunne WM; Coopersmith CM
  • The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.
    Crit Care Resusc Volume: 10 Page(s): 8
    03/01/2008 Authors: Hicks P; Cooper DJ; Australian and New Zealand Intensive Care Society (ANZICS) Board and Clinical Trials Group Executive Committee
  • Improved extubation rates and earlier liberation from mechanical ventilation with implementation of a daily spontaneous-breathing trial protocol.
    J Am Coll Surg Volume: 206 Page(s): 489 - 495
    03/01/2008 Authors: Robertson TE; Sona C; Schallom L; Buckles M; Cracchiolo L; Schuerer D; Coopersmith CM; Song F; Buchman TG
  • Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram.
    PLoS One Volume: 3 Page(s): e1564
    02/13/2008 Authors: McDunn JE; Husain KD; Polpitiya AD; Burykin A; Ruan J; Li Q; Schierding W; Lin N; Dixon D; Zhang W
  • Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.
    J Am Coll Surg Volume: 206 Page(s): 335 - 342
    02/01/2008 Authors: Schwulst SJ; Muenzer JT; Chang KC; Brahmbhatt TS; Coopersmith CM; Hotchkiss RS
  • Intestinal overexpression of epidermal growth factor inhibits gut epithelial apoptosis and improves mortality in sepsis
    Volume: 29 Page(s): 99 - 100
    01/01/2008 Authors: Clark JA; Hotchkiss RS; Buchman TG; Coopersmith CM
  • Radiation worsens survival in pneumonia: Developing an animal model of post-radiation sepsis
    Volume: 29 Page(s): 74 - 74
    01/01/2008 Authors: Brahmamdam P; Davis CG; Perrone EE; McDonough JS; Osborne DF; Muenzer JT; Coopersmith CM; Hotchkiss RS
  • Mechanisms of epithelial resistance to Entamoeba histolytica-induced gut injury
    Volume: 14 Page(s): S32 - S32
    01/01/2008 Authors: Cho K; Hamano S; Becker S; Guo X; Stroup S; Coopersmith C; Leiter E; Houpt E
  • Sepsis from pseudomonas aeruginosa pneumonia superimposed on pancreatic cancer increases gut epithelial apoptosis, bacteremia, and mortality
    Volume: 29 Page(s): 95 - 95
    01/01/2008 Authors: Fox A; Robertson C; Belt B; Dunne WM; Linehan D; Buchman T; Hotchkiss R; Coopersmith C
  • Modulation of Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages
    Volume: 29 Page(s): 3 - 3
    01/01/2008 Authors: Peck-Palmer O; Unsinger J; Chang K; McDunn JE; Coopersmith C; Hotchkiss R
  • Radiation injury increases systemic infection and mortality in murine MRSA pneumonia
    Volume: 29 Page(s): 100 - 100
    01/01/2008 Authors: Perrone EE; Brahmamdan P; Davis CG; McDonough JS; Buchman TG; Hotchkiss RS; Coopersmith CM
  • Anti-TNF modulates mortality from S. pneumoniae and P. aeruginosa pneumonia in mice
    Volume: 29 Page(s): 97 - 97
    01/01/2008 Authors: Clark AT; McConnell KW; Dunne WM; Dixon DJ; Cobb JP; Buchman TG; Hotchkiss RS; Coopersmith CM
  • Sepsis from pseudomonas aeruginosa pneumonia decreases jejunal epithelial proliferation and migration with partial recovery of regenerative capacity 48 hours post-injury
    Volume: 35 Page(s): A54 - A54
    12/01/2007 Authors: Fox AC; Clark AT; Zee-Cheng B; Dunne WM; Buchman TG; Hotchkiss RS; Coopersmith CM
  • Implementation of a transition insulin protocol to maintain glycemic control after intensive insulin therapy
    Volume: 35 Page(s): A137 - A137
    12/01/2007 Authors: Taylor B; Byrnes M; Quist M; Schallom M; Sona C; Coopersmith C; Boyle W; Buchman T; Tobin G
  • NF-kappa B activation in enterocytes reduces sepsis-induced gut injury
    Volume: 35 Page(s): A3 - A3
    12/01/2007 Authors: Clark J; Samocha A; Hotchkiss R; Buchman T; Coopersmith C
  • Increasing patient safety in a SICU: Staff safety concerns survey
    Volume: 35 Page(s): A173 - A173
    12/01/2007 Authors: Gnerlich JL; Coopersmith C; Fraser V; Schuerer D
  • Loss of EGF receptor activity leads to increased intestinal apoptosis and decreased villus height in sepsis
    Volume: 35 Page(s): A52 - A52
    12/01/2007 Authors: Perrone E; Clark J; Hotchkiss R; Buchman T; Coopersmith C
  • Novel models of murine sepsis with comorbid pancreatic cancer
    Volume: 35 Page(s): A57 - A57
    12/01/2007 Authors: Hotchkiss RS; Robertson CM; Belt BA; Linehan DC; Buchman TG; Coopersmith CM
  • Daily review of a checklist of ICU guidelines improves adherence to established ICU protocols and objectives
    Volume: 35 Page(s): A23 - A23
    12/01/2007 Authors: Schallom ME; Sona CS; Schuerer DJ; Mazuski JE; McKenzie W; Taylor BE; Boyle WA; Coopersmith CM; Byrnes M
  • Age increases local but not systemic inflammation in murine sepsis
    Volume: 35 Page(s): A61 - A61
    12/01/2007 Authors: Clark AT; Turnbull IR; Stromberg PE; Woolsey CA; Buchman TG; Horchkiss RS; Coopersmith CM
  • Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
    J Clin Invest Volume: 117 Page(s): 3445 - 3452
    11/01/2007 Authors: Graham DB; Robertson CM; Bautista J; Mascarenhas F; Diacovo MJ; Montgrain V; Lam SK; Cremasco V; Dunne WM; Faccio R
  • Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness.
    Shock Volume: 28 Page(s): 384 - 393
    10/01/2007 Authors: Clark JA; Coopersmith CM
  • Mitochondrial resuscitation with exogenous cytochrome c in the septic heart.
    Crit Care Med Volume: 35 Page(s): 2120 - 2127
    09/01/2007 Authors: Piel DA; Gruber PJ; Weinheimer CJ; Courtois MR; Robertson CM; Coopersmith CM; Deutschman CS; Levy RJ
  • Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit.
    Clin Infect Dis Volume: 45 Page(s): 541 - 547
    09/01/2007 Authors: Jones JC; Rogers TJ; Brookmeyer P; Dunne WM; Storch GA; Coopersmith CM; Fraser VJ; Warren DK
  • Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial.
    Surg Infect (Larchmt) Volume: 8 Page(s): 445 - 454
    08/01/2007 Authors: Schuerer DJE; Zack JE; Thomas J; Borecki IB; Sona CS; Schallom ME; Venker M; Nemeth JL; Ward MR; Verjan L
  • Prevention of catheter-related blood stream infection.
    Curr Opin Crit Care Volume: 13 Page(s): 411 - 415
    08/01/2007 Authors: Byrnes MC; Coopersmith CM
  • Decreased mortality following epidermal growth factor treatment is associated with improved gut integrity in sepsis
    Volume: 27 Page(s): 1 - 1
    06/01/2007 Authors: Clark J; Hotchkiss R; Buchman T; Coopersmith C
  • Monocyte/macrophage apoptosis occurs with radiation and serum-deprivation but not E-coli
    Volume: 27 Page(s): 7 - 7
    06/01/2007 Authors: Peck-Palmer OM; McConnell K; Unsinger J; Chang K; McDunn JE; Coopersmith CM; Hotchkiss RS
  • The survival advantage conferred by prevention of gut epithelial apoptosis in sepsis occurs through the mitochondrial pathway and is dependent upon the presence of the adaptive immune system
    Volume: 27 Page(s): 5 - 5
    06/01/2007 Authors: McConnell K; Stromberg P; Woolsey C; Clark A; Clark J; Hotchkiss R; Buchman T; Coopersmith C
  • Neutrophil depletion inhibits pulmonary clearance of Stahpylocuccus aureus in mice
    Volume: 27 Page(s): 47 - 47
    06/01/2007 Authors: Robertson C; McConnell K; Martin J; Boody B; Dunne M; Hotchkiss R; Buchman T; Coopersmith C
  • Aging modulates local but not systemic inflammation following cecal ligation and puncture (CLP) in mice
    Volume: 27 Page(s): 54 - 55
    06/01/2007 Authors: Clark A; Turnbull I; Stromberg P; Woolsey C; Buchman T; Hotchkiss R; Coopersmith C
  • Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine.
    Histol Histopathol Volume: 22 Page(s): 623 - 630
    06/01/2007 Authors: Vyas D; Robertson CM; Stromberg PE; Martin JR; Dunne WM; Houchen CW; Barrett TA; Ayala A; Perl M; Buchman TG
  • Just the right amount of JNK: How nuclear factor-kappaB and downstream mediators prevent burn-induced intestinal injury.
    Crit Care Med Volume: 35 Page(s): 1433 - 1434
    05/01/2007 Authors: Clark JA; Coopersmith CM
  • Anti-apoptotic peptides protect against radiation-induced cell death.
    Biochem Biophys Res Commun Volume: 355 Page(s): 501 - 507
    04/06/2007 Authors: McConnell KW; Muenzer JT; Chang KC; Davis CG; McDunn JE; Coopersmith CM; Hilliard CA; Hotchkiss RS; Grigsby PW; Hunt CR
  • Patient safety event reporting in critical care: a study of three intensive care units.
    Crit Care Med Volume: 35 Page(s): 1068 - 1076
    04/01/2007 Authors: Harris CB; Krauss MJ; Coopersmith CM; Avidan M; Nast PA; Kollef MH; Dunagan WC; Fraser VJ
  • Long-term outcomes of performing a postdoctoral research fellowship during general surgery residency.
    Ann Surg Volume: 245 Page(s): 516 - 523
    04/01/2007 Authors: Robertson CM; Klingensmith ME; Coopersmith CM
  • Gram positive and gram negative pneumonia induce unique systemic cytokine profiles
    INFLAMMATION RESEARCH Volume: 56 Page(s): S128 - S128
    03/01/2007 Authors: McConnell K; McDunn J; Turnbull I; Dixon D; Dunne M; Coopersmith C
  • Sepsis from pseudomonas aeruginosa pneumonia decreases intestinal epithelial proliferation and slows migration
    INFLAMMATION RESEARCH Volume: 56 Page(s): S158 - S158
    03/01/2007 Authors: Clark AT; Woolsey CA; Dunne WM; Buchman TG; Hotchkiss RS; Coopersmith CM
  • Tat-BH4 decreases intestinal epithelial cell death after septic insult in vitro
    INFLAMMATION RESEARCH Volume: 56 Page(s): S73 - S74
    03/01/2007 Authors: Robertson C; Chang K; McConnell K; Houchen C; Hotchkiss R; Coopersmith C
  • Exogenous epidermal growth factor improves intestinal integrity in sepsis
    INFLAMMATION RESEARCH Volume: 56 Page(s): S174 - S174
    03/01/2007 Authors: Clark J; Stromberg P; Hotchkiss R; Buchman T; Coopersmith C
  • Adoptive transfer of dying cells causes bystander-induced apoptosis.
    Biochem Biophys Res Commun Volume: 353 Page(s): 780 - 785
    02/16/2007 Authors: Schwulst SJ; Davis CG; Coopersmith CM; Hotchkiss RS
  • Impact of a methicillin-resistant Staphylococcus aureus active surveillance program on contact precaution utilization in a surgical intensive care unit.
    Crit Care Med Volume: 35 Page(s): 430 - 434
    02/01/2007 Authors: Warren DK; Guth RM; Coopersmith CM; Merz LR; Zack JE; Fraser VJ
  • Use of hypochlorite solution to decrease rates of Clostridium difficile-associated diarrhea.
    Infect Control Hosp Epidemiol Volume: 28 Page(s): 205 - 207
    02/01/2007 Authors: McMullen KM; Zack J; Coopersmith CM; Kollef M; Dubberke E; Warren DK
  • Patients' and surrogates' perspective on research and testing in critical care.
    Crit Care Med Volume: 35 Page(s): 328 - 329
    01/01/2007 Authors: Freeman BD; Kennedy CR; Coopersmith CM; Zehnbauer BA; Buchman TG
  • Effects of pelvic, pudendal, or hypogastric nerve cuts on Fos induction in the rat brain following vaginocervical stimulation.
    Physiol Behav Volume: 89 Page(s): 627 - 636
    12/30/2006 Authors: Pfaus JG; Manitt C; Coopersmith CB
  • Peptide transduction domain delwery of anti-apoptotic proteins decreases splenocyte apoptosis in pre- and post-treatment models of murine radiation injury.
    Volume: 34 Page(s): A44 - A44
    12/01/2006 Authors: McConnell KW; Muenzer JT; Chang KC; Coopersmith CM; Grigbsy PW; Hotchkiss RS; Hunt CR
  • Neutrophil depletion allows creation of a virulent murine model of staphylococcus aureus pneumonia.
    Volume: 34 Page(s): A35 - A35
    12/01/2006 Authors: Robertson CM; Martin J; Boody B; Dunne M; Hotchkiss R; Buchman T; Coopersmith CM
  • Increase in extubation rate with implementation of daily spontaneous breathing trials.
    Volume: 34 Page(s): A87 - A87
    12/01/2006 Authors: Robertson TE; Cracchiolo L; Marcy B; Schallom L; Carrie S; Song F; Douglas S; Coopersmith C; Buchman TG
  • Epidemiology of methicillin-resistant Staphylococcus aureus colonization in a surgical intensive care unit.
    Infect Control Hosp Epidemiol Volume: 27 Page(s): 1032 - 1040
    10/01/2006 Authors: Warren DK; Guth RM; Coopersmith CM; Merz LR; Zack JE; Fraser VJ
  • Epidemiology of methicillin-resistant Staphylococcus aureus colonization in a surgical intensive care unit (vol 27, pg 1032, 2006)
    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY Volume: 27 Page(s): 1140 - 1141
    10/01/2006 Authors: Warren DK; Guth RM; Coopersmith CM; Merz LR; Zack JE; Fraser VJ
  • Long-term outcomes of performing laboratory research during surgical residency
    Volume: 203 Page(s): S76 - S76
    09/01/2006 Authors: Robertson CM; Klingensmith M; Coopersmith C
  • Modeling aging and sepsis.
    Volume: 25 Page(s): 13 - 14
    06/01/2006 Authors: Tumbull I; Buchman T; Coopersmith C
  • An examination of mechanisms underlying the survival benefit conferred by intestinespecific overexpression of interleukin-10.
    Volume: 25 Page(s): 47 - 47
    06/01/2006 Authors: Rajan S; Woolsey C; Buchman T; Hotchkiss R; Coopersmith C
  • Gram positive and gram negative murine pneumonia induce unique local cytokine profiles.
    Volume: 25 Page(s): 47 - 47
    06/01/2006 Authors: McConnell K; Dunne M; Buchman T; Hotchkiss R; Coopersmith C
  • HSP70.1 and HSP70.3 mediate survival following cecal ligation and puncture in aged male mice.
    Volume: 25 Page(s): 7 - 8
    06/01/2006 Authors: Clark AT; McConnell KW; Hunt CR; Buchman TG; Hotchkiss RS; Coopersmith CM
  • A new safety event reporting system improves physician reporting in the surgical intensive care unit.
    J Am Coll Surg Volume: 202 Page(s): 881 - 887
    06/01/2006 Authors: Schuerer DJE; Nast PA; Harris CB; Krauss MJ; Jones RM; Boyle WA; Buchman TG; Coopersmith CM; Dunagan WC; Fraser VJ
  • Aged mice have altered cytokine profiles and intestinal permeability following cecal ligation and puncture.
    Volume: 25 Page(s): 76 - 77
    06/01/2006 Authors: Woolsey CA; Stromberg PE; Hotchkiss RS; Buchman TG; Coopersmith CM
  • Mitochondrial resuscitation with exogenous cytochrome C in the septic heart
    Volume: 25 Page(s): 16 - 16
    06/01/2006 Authors: Patel DA; Gruber PJ; Weinheimer CJ; Courtois MR; Robertson CM; Coopersmith CM; Deutschman CS; Levy RJ
  • TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.
    J Immunol Volume: 176 Page(s): 5471 - 5477
    05/01/2006 Authors: Hotchkiss RS; McConnell KW; Bullok K; Davis CG; Chang KC; Schwulst SJ; Dunne JC; Dietz GPH; Bhr M; McDunn JE
  • Genetic research and testing in critical care: surrogates' perspective.
    Crit Care Med Volume: 34 Page(s): 986 - 994
    04/01/2006 Authors: Freeman BD; Kennedy CR; Coopersmith CM; Zehnbauer BA; Buchman TG
  • Vasoactive drugs and the gut: is there anything new?
    Curr Opin Crit Care Volume: 12 Page(s): 155 - 159
    04/01/2006 Authors: Woolsey CA; Coopersmith CM
  • The systemic inflammatory response syndrome.
    Microbes Infect Volume: 8 Page(s): 1382 - 1389
    04/01/2006 Authors: Robertson CM; Coopersmith CM
  • Efficacy and safety of an insulin infusion protocol in a surgical ICU.
    J Am Coll Surg Volume: 202 Page(s): 1 - 9
    01/01/2006 Authors: Taylor BE; Schallom ME; Sona CS; Buchman TG; Boyle WA; Mazuski JE; Schuerer DE; Thomas JM; Kaiser C; Huey WY
  • Identifying the optimal method to quantify gut apoptosis in critical illness
    Volume: 33 Page(s): A145 - A145
    12/01/2005 Authors: Robertson CM; Stromberg P; Vyas D; Martin J; Sherman B; Buchman T; Coopersmith C; Hotchkiss R
  • A simple, low-cost oral care protocol reduces ventilator-associated pneumonia rates.
    Volume: 33 Page(s): A13 - A13
    12/01/2005 Authors: Sona C; Zack J; Schallom L; Schwartkopf L; Huey W; McSweeney M; McMullen K; Mazuski J; Schuerer D; Coopersmith C
  • The effect of age on myocardial gene expression profiles in a murine model of sepsis
    Volume: 33 Page(s): A142 - A142
    12/01/2005 Authors: Checchia PA; Polpitiya A; MacMillan S; Stromberg P; Coopersmith CM; Buchman TG; Cobb JP
  • Intestine specific overexpression of IL-10 improves survival in a polymicrobial model of sepsis.
    Volume: 33 Page(s): A133 - A133
    12/01/2005 Authors: Rajan S; Vyas D; Buchman TG; Coopersmith CM; Hotchkiss RS
  • TLR4 signaling changes white blood cell distribution in Pseudomonas pneumonia
    Volume: 33 Page(s): A143 - A143
    12/01/2005 Authors: Woolsey CA; McConnell K; Martin J; Boody B; Hotchkiss RS; Karl IE; Coopersmith CM
  • Epithelial cells.
    Crit Care Med Volume: 33 Page(s): S520 - S522
    12/01/2005 Authors: McConnell KW; Coopersmith CM
  • Gene expression analysis of E-coli induced apoptosis of human lymphocytes and the protective effect of Tat-BH4.
    Volume: 33 Page(s): A135 - A135
    12/01/2005 Authors: Wagner TH; McConnell KW; Chang KC; Dunne JC; Yuan KZ; Cobb JP; Karl IE; Coopersmith CM; Hotchkiss RS
  • Prevention of lymphocyte apoptosis--a potential treatment of sepsis?
    Clin Infect Dis Volume: 41 Suppl 7 Page(s): S465 - S469
    11/15/2005 Authors: Hotchkiss RS; Coopersmith CM; Karl IE
  • Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients.
    Crit Care Med Volume: 33 Page(s): 2513 - 2520
    11/01/2005 Authors: Freeman BD; Borecki IB; Coopersmith CM; Buchman TG
  • Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury.
    Crit Care Med Volume: 33 Page(s): 2350 - 2357
    10/01/2005 Authors: Husain KD; Stromberg PE; Woolsey CA; Turnbull IR; Dunne WM; Javadi P; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.
    Am J Physiol Regul Integr Comp Physiol Volume: 289 Page(s): R1048 - R1053
    10/01/2005 Authors: Vyas D; Javadi P; Dipasco PJ; Buchman TG; Hotchkiss RS; Coopersmith CM
  • Iron dysregulation combined with aging prevents sepsis-induced apoptosis.
    J Surg Res Volume: 128 Page(s): 37 - 44
    09/01/2005 Authors: Javadi P; Buchman TG; Stromberg PE; Turnbull IR; Vyas D; Hotchkiss RS; Karl IE; Coopersmith CM
  • Gram positive and gram negative murine pneumonia induce distinct changes in lymphocyte apoptosis and neutrophil migration.
    Volume: 23 Page(s): 55 - 55
    06/01/2005 Authors: McConnell K; DiPasco P; Chang K; Schreiber T; Vyas D; Dunne M; Buchman T; Hotchkiss R; Coopersmith C
  • Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.
    J Virol Volume: 79 Page(s): 7492 - 7502
    06/01/2005 Authors: Markovics JA; Carroll PA; Robles MTS; Pope H; Coopersmith CM; Pipas JM
  • Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.
    J Immunol Volume: 174 Page(s): 5110 - 5118
    04/15/2005 Authors: Hotchkiss RS; Osmon SB; Chang KC; Wagner TH; Coopersmith CM; Karl IE
  • Molecular diagnostics in pneumonia.
    Volume: 23 Page(s): 2 - 3
    01/01/2005 Authors: McDunn JE; Husain KD; Coopersmith C; Dunne M; Townsend RR; Cobb JP
  • Levosimendan and gut mucosal blood flow--not all inotropes are created equal.
    Crit Care Med Volume: 33 Page(s): 246 - 247
    01/01/2005 Authors: Coopersmith CM
  • Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium.
    Shock Volume: 22 Page(s): 364 - 368
    10/01/2004 Authors: Turnbull IR; Buchman TG; Javadi P; Woolsey CA; Hotchkiss RS; Karl IE; Coopersmith CM
  • Comparison of the plasma proteome during Gram-positive and Gram-negative pneumonia in mice
    Volume: 199 Page(s): S42 - S43
    09/01/2004 Authors: McDunn JE; Husain KD; Coopersmith CM; Townsend RR; Cobb JP
  • Sequence makes a difference: paradoxical effects of stress in vivo.
    Shock Volume: 22 Page(s): 229 - 233
    09/01/2004 Authors: Wizorek JJ; Coopersmith CM; Laramie JM; Tong A; Stromberg PE; Hotchkiss RS; Buchman TG; Cobb JP
  • High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis.
    Crit Care Med Volume: 32 Page(s): 1178 - 1185
    05/01/2004 Authors: Javadi P; Buchman TG; Stromberg PE; Husain KD; Dunne WM; Woolsey CA; Turnbull IR; Hotchkiss RS; Karl IE; Coopersmith CM
  • The impact of bedside behavior on catheter-related bacteremia in the intensive care unit.
    Arch Surg Volume: 139 Page(s): 131 - 136
    02/01/2004 Authors: Coopersmith CM; Zack JE; Ward MR; Sona CS; Schallom ME; Everett SJ; Huey WY; Garrison TM; McDonald J; Buchman TG
  • Mitochondrial membrane dysfunction in endotoxemia: the difference between what's in and what's out.
    Crit Care Med Volume: 32 Page(s): 607 - 609
    02/01/2004 Authors: Coopersmith CM
  • Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit.
    J Am Coll Surg Volume: 198 Page(s): 198 - 204
    02/01/2004 Authors: Taylor BE; Huey WY; Buchman TG; Boyle WA; Coopersmith CM
  • Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels.
    Shock Volume: 21 Page(s): 121 - 125
    02/01/2004 Authors: Turnbull IR; Javadi P; Buchman TG; Hotchkiss RS; Karl IE; Coopersmith CM
  • The adaptive immune system mediates gut epithelial apoptosis following cecal ligation and puncture
    Volume: 21 Page(s): 39 - 39
    01/01/2004 Authors: Woolsey CA; Stromberg PE; Javadi P; Husain KD; Chang KC; Hotchkiss RS; Karl IE; Buchman TG; Coopersmith CM
  • Exogenous iron after sepsis increases mortality and an alters apoptosis
    Volume: 21 Page(s): 130 - 130
    01/01/2004 Authors: Javadi P; Stromberg PE; Husain KD; Woolsey CA; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Gut over-expression of Bcl-2 requires lymphocytes to improve survival
    Volume: 21 Page(s): 54 - 54
    01/01/2004 Authors: Stromberg PE; Chang KC; Woolsey CW; Hotchkiss WR; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Mice expressing caspase-3 resistant retinoblastoma protein have decreased gut epithelial but not splenic apoptosis in Pseudomonas aeruginosa pneumonia
    Volume: 21 Page(s): 37 - 37
    01/01/2004 Authors: Stromberg PE; Woolsey CA; Husain KD; Dunne WM; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Lung injury uncouples gut apoptosis and proliferation
    Volume: 21 Page(s): 55 - 55
    01/01/2004 Authors: Husain KD; Stromberg PE; Woolsey CA; Turnbull IR; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Gut epithelial apoptosis occurs via the mitochondrial and receptor-mediated pathways in streptococcus pneumoniae pneumonia
    Volume: 21 Page(s): 22 - 22
    01/01/2004 Authors: Husain KD; Stromberg PE; Woolsey CA; Dunne WM; Buchman TG; Karl IE; Hotchkiss RS; Coppersmith CM
  • Gut epithelial and splenic apoptosis in septic HFE-/- mice are age dependent
    Volume: 21 Page(s): 33 - 33
    01/01/2004 Authors: Javadi P; Buchman TG; Turnbull IR; Stromberg PE; Coopersmith CM
  • Gut apoptosis and proliferation in acute lung injury: The role of Bcl-2, TLR4, and TNF
    Volume: 31 Page(s): A1 - A1
    12/01/2003 Authors: Husain KD; Stromberg PE; Woolsey CA; Hotchkiss WR; Buchman TG; Hotchkiss RS; Karl IE; Coopersmith CM
  • Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival.
    Shock Volume: 20 Page(s): 437 - 443
    11/01/2003 Authors: Husain KD; Stromberg PE; Javadi P; Buchman TG; Karl IE; Hotchkiss RS; Coopersmith CM
  • Abdominal compartment syndrome in a patient resulting from pneumothorax.
    Intensive Care Med Volume: 29 Page(s): 1614
    09/01/2003 Authors: Ali SZ; Freeman BD; Coopersmith CM
  • Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.
    Crit Care Med Volume: 31 Page(s): 1630 - 1637
    06/01/2003 Authors: Coopersmith CM; Stromberg PE; Davis CG; Dunne WM; Amiot DM; Karl IE; Hotchkiss RS; Buchman TG
  • Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia.
    Shock Volume: 19 Page(s): 408 - 414
    05/01/2003 Authors: Coopersmith CM; Amiot DM; Stromberg PE; Dunne WM; Davis CG; Osborne DF; Husain KD; Turnbull IR; Karl IE; Hotchkiss RS
  • Role of intestinal epithelial apoptosis in survival.
    Curr Opin Crit Care Volume: 9 Page(s): 159 - 163
    04/01/2003 Authors: Husain KD; Coopersmith CM
  • Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
    Shock Volume: 19 Page(s): 310 - 313
    04/01/2003 Authors: Turnbull IR; Wlzorek JJ; Osborne D; Hotchkiss RS; Coopersmith CM; Buchman TG
  • Aging is associated with increased IL-6 and splenic apoptosis following cecal ligation and puncture
    Volume: 31 Page(s): A9 - A9
    02/01/2003 Authors: Javadi P; Turnbull IR; Coopersmith CM; Buchman TG; Hotchkiss RS
  • Acute lung injury causes increased gut epithelial apoptosis and decreased proliferation in mice
    Volume: 31 Page(s): A10 - A10
    02/01/2003 Authors: Husain KD; Stromberg PE; Turnbull IR; Buchman TG; Coopersmith CM; Hotchkiss RS; Dunne WM; Karl IE
  • Acute lung injury causes increased gut epithelial apoptosis and decreased proliferation in mice
    Volume: 30 Page(s): A10 - A10
    12/01/2002 Authors: Husain KD; Stromberg PE; Turnbull IR; Buchman TG; Coopersmith CM
  • Aging is associated with increased IL-6 and splenic apoptosis following cecal ligation and puncture
    Volume: 30 Page(s): A9 - A9
    12/01/2002 Authors: Javadi P; Turnbull IR; Coopersmith CM; Buchman TG
  • Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia.
    Crit Care Med Volume: 30 Page(s): 2407 - 2412
    11/01/2002 Authors: Zack JE; Garrison T; Trovillion E; Clinkscale D; Coopersmith CM; Fraser VJ; Kollef MH
  • Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.
    JAMA Volume: 287 Page(s): 1716 - 1721
    04/03/2002 Authors: Coopersmith CM; Stromberg PE; Dunne WM; Davis CG; Amiot DM; Buchman TG; Karl IE; Hotchkiss RS
  • Depletion of dendritic cells, but not macrophages, in patients with sepsis.
    J Immunol Volume: 168 Page(s): 2493 - 2500
    03/01/2002 Authors: Hotchkiss RS; Tinsley KW; Swanson PE; Grayson MH; Osborne DF; Wagner TH; Cobb JP; Coopersmith C; Karl IE
  • Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice.
    Crit Care Med Volume: 30 Page(s): 195 - 201
    01/01/2002 Authors: Coopersmith CM; Chang KC; Swanson PE; Tinsley KW; Stromberg PE; Buchman TG; Karl IE; Hotchkiss RS
  • Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit.
    Crit Care Med Volume: 30 Page(s): 59 - 64
    01/01/2002 Authors: Coopersmith CM; Rebmann TL; Zack JE; Ward MR; Corcoran RM; Schallom ME; Sona CS; Buchman TG; Boyle WA; Polish LB
  • Hepatocellular carcinoma in a patient with focal nodular hyperplasia.
    HPB (Oxford) Volume: 4 Page(s): 135 - 138
    01/01/2002 Authors: Coopersmith CM; Lowell JA; Hassan A; Howard TK
  • Clinical effectiveness of a phosphorus repletion protocol in a surgical intensive care unit
    CRITICAL CARE MEDICINE Volume: 29 Page(s): A161 - A161
    12/01/2001 Authors: Taylor B; Huey W; Coopersmith C; Buchman T
  • Overexpression of Bcl-2 in the intestinal epithelium improves survival in a model of pseudomonas pneumonia-induced sepsis
    CRITICAL CARE MEDICINE Volume: 29 Page(s): A9 - A9
    12/01/2001 Authors: Coopersmith CM; Stromberg PE; Dunne WM; Davis CG; Buchman TG; Hotchkiss RS
  • Renal transplantation following previous heart, liver, and lung transplantation: an 8-year single-center experience.
    Surgery Volume: 130 Page(s): 457 - 462
    09/01/2001 Authors: Coopersmith CM; Brennan DC; Miller B; Wang C; Hmiel P; Shenoy S; Ramachandran V; Jendrisak MD; Ceriotti CS; Mohanakumar T
  • Renal transplantation following previous heart, liver and lung transplantation - An 8 year, single-center experience.
    TRANSPLANTATION Volume: 69 Page(s): S324 - S324
    04/27/2000 Authors: Coopersmith CM; Brennan DC; Singer GG; Miller B; Shenoy S; Ramachandran V; Mohanakumar T; Ceriotti CS; Howard TK; Lowell JA
  • Unusual presentations of nonmycotic hepatic artery pseudoaneurysms after liver transplantation.
    Liver Transpl Surg Volume: 5 Page(s): 200 - 203
    05/01/1999 Authors: Lowell JA; Coopersmith CM; Shenoy S; Howard TK
  • Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice.
    Am J Physiol Volume: 276 Page(s): G677 - G686
    03/01/1999 Authors: Coopersmith CM; O'Donnell D; Gordon JI
  • Surgery of the small intestine.
    Curr Opin Gastroenterol Volume: 15 Page(s): 146 - 150
    03/01/1999 Authors: Coopersmith CM; Lowell JA
  • Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle.
    J Cell Biol Volume: 138 Page(s): 167 - 179
    07/14/1997 Authors: Coopersmith CM; Chandrasekaran C; McNevin MS; Gordon JI
  • gamma-Ray-induced apoptosis in transgenic mice with proliferative abnormalities in their intestinal epithelium: re-entry of villus enterocytes into the cell cycle does not affect their radioresistance but enhances the radiosensitivity of the crypt by inducing p53.
    Oncogene Volume: 15 Page(s): 131 - 141
    07/10/1997 Authors: Coopersmith CM; Gordon JI
  • Use of normal and transgenic mice to examine the relationship between terminal differentiation of intestinal epithelial cells and accumulation of their cell cycle regulators.
    J Biol Chem Volume: 271 Page(s): 28414 - 28421
    11/08/1996 Authors: Chandrasekaran C; Coopersmith CM; Gordon JI
  • Radiation-induced apoptosis in the small intestine of transgenic mice: Additional evidence for cell nonautonomous regulation.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 44 Page(s): A318 - A318
    03/01/1996 Authors: Coopersmith CM; Chandrasekaran C; Gordon JI
  • Acute renal failure.
    Lancet Volume: 347 Page(s): 478 - 479
    02/17/1996 Authors: Bihari D; Mitchell I; Chang R
  • Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice.
    Proc Natl Acad Sci U S A Volume: 91 Page(s): 6914 - 6918
    07/19/1994 Authors: Kim SH; Roth KA; Coopersmith CM; Pipas JM; Gordon JI
  • THE ROLE OF MLCK IN SEPSIS-INDUCED INTESTINAL HYPERPERMEABILITY

    Authors: Lorentz CA; Yoseph BP; Breed ER; Liang Z; Mittal R; Coopersmith C
  • MYOSIN LIGHT CHAIN KINASE KNOCKOUT CONFERS A SURVIVAL ADVANTAGE IN POLYMICROBIAL SEPSIS ASSOCIATED WITH UPREGULATION OF ZO-1 AND CLAUDIN-15

    Authors: Lorentz AC; Liang Z; Mittal R; Coopersmith CM
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