Christian Larsen MD/PhD
Overview
Dr. Larsen has made seminal contributions to the investigation of the immunologic mechanisms of transplant rejection and immunologic tolerance and is an internationally recognized leader in kidney and pancreas transplantation. He has been funded continuously by the NIH since 1996. The recipient of a prestigious NIH MERIT award, he has directed program project grants, center awards, and multi-institutional consortia.
With his long-time collaborator Dr. Thomas Pearson, Dr. Larsen initiated a transplant immunology research program that played a pivotal role in developing a new class of immunosuppressive drugs known as costimulation blockers. One such drug is belatacept, which Dr. Larsen, Dr. Pearson, and researchers at Bristol Myers Squibb began developing in the 1990s as a less toxic alternative to standard immunosuppressants. In 2011, the FDA approved belatacept in the form of the drug Nulojix for kidney transplant recipients. In 2015, the BENEFIT study, which was initiated in 2006 and led by Dr. Larsen and UCSF transplant specialist Dr. Flavio Vincenti, conclusively showed that belatacept had a better record of patient and organ survival than a calcineurin inhibitor.
In 2012, Dr. Larsen received an NIH grant for nearly $20 million to lead teams of multiple investigators attacking the problems of immunosuppression from different but complementary angles. The connective focus is continued development of more effective co-stimulation blockers for near-term treatment of transplant patients and better strategies for the "holy grail" of transplantationlong-term, true immune tolerance of transplanted organs.
Dr. Larsen began serving as executive director of the Emory Transplant Center in 2008 and chair of the Department of Surgery at Emory in 2009. He left both positions in January 2013 to serve as dean of the Emory University School of Medicine. In November 2016, Dr. Larsen returned to full-time pursuit of his clinical practice and research endeavors at the Department of Surgery and Emory Transplant Center.
In 2017, the National Institute of Allergy and Infectious Diseases awarded Emory transplant researchers $12.6 million over five years to investigate improved post-transplant drug regimens for organ transplant recipients. Dr. Larsen leads the grant's project team, which includes Mandy Ford, PhD, at Emory, and Leslie Kean, MD, PhD, at Seattle Children's Hospital and the University of Washington. The project is continuing Dr. Larsen's work on costimulation blockers.
Academic Appointment
- Professor of Surgery, Department of Surgery, Emory University School of Medicine
Education
Degrees
- Doctor of Philosophy from University of Oxford
- Bachelor of Arts from Emory College
- Doctor of Medicine from Emory University School of Medicine
Research
Focus
- Our work focuses on understanding the mechanisms involved in initiation and maintenance of T cell responses. We aim to develop new immunosuppressive strategies to prevent transplant rejection and preserve protective immunity. A key strategy in our research program is to tightly link projects and investigations that span basic, translational, and clinical research using murine, non-human primate and human models.
Publications
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Impact of Severe Persistent BK Polyomavirus on Graft Function and Quality of Life Outcomes in Kidney Transplant Recipients.
Transpl Infect Dis Page(s): e70010
03/18/2025 Authors: Eichenberger EM; Magua W; Karadkhele G; Zhou G; Vasanth P; Larsen C -
Early Post-Transplant Renal Recovery Trajectory and Trajectory Velocity Functions Are Predictors of Estimated GFR at 1 Year: A Functional Data Analysis Approach.
Clin Transplant Volume: 39 Page(s): e70119
03/01/2025 Authors: Magua W; Cristea O; Eichenberger EM; Karadkhele GM; Morris AA; Newell K; Rickert JB; Larsen CP -
Identification of indirect CD4+ Tcell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction.
Immunity Volume: 58 Page(s): 448 - 464.e6
02/11/2025 Authors: Zhanzak Z; Johnson AC; Foster P; Cardenas MA; Morris AB; Zhang J; Karadkhele G; Badell IR; Morris AA; Au-Yeung BB -
Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: Results of a prospective, multicenter cohort study.
Am J Transplant
11/04/2024 Authors: Tanimine N; Markmann JF; Wood-Trageser MA; Demetris AJ; Mason K; Silva JAF; Levitsky J; Feng S; Humar A; Emond JC -
Major histocompatibility complex and peptide specificity underpin CD8+ T cell direct alloresponse.
Am J Transplant
10/20/2024 Authors: Zhang W; Roversi FM; Morris AB; Ortiz K; Zhou G; Hadley A; Zhang X; Silva JAF; Breeden CP; Zhanzak Z -
Evaluating Real-World Experience With Maribavir for Treatment of Refractory/Resistant Cytomegalovirus in Renal Transplant Recipients.
Clin Transplant Volume: 38 Page(s): e15480
10/01/2024 Authors: Beechar VB; Phadke VK; Pouch SM; Mehta AK; Karadkhele G; Larsen CP; Woodworth MH -
Belatacept-based immunosuppression does not confer increased risk of BK polyomavirus-DNAemia relative to tacrolimus-based immunosuppression.
Transpl Infect Dis Volume: 26 Page(s): e14298
10/01/2024 Authors: Eichenberger EM; Magua W; Rickert JB; Karadkhele G; Fallahzadeh MK; Vasanth P; Larsen C -
Long-term Safety in Epstein-Barr Virus-Seropositive Kidney-only Transplant Recipients Treated With Belatacept in Clinical Practice: Final Study Results From the ENLiST Registry.
Transplant Direct Volume: 10 Page(s): e1644
06/01/2024 Authors: Larsen CP; Vincenti F; D Kou T; Shadur CA; Bresnahan B; Jordan SC; Woodle ES; Goes N; Vella J; Wojciechowski D -
Detectable plasma severe acute respiratory syndrome coronavirus 2 spike antigen is associated with poor antibody response following third messenger RNA vaccination in kidney transplant recipients.
Transpl Infect Dis Volume: 26 Page(s): e14281
06/01/2024 Authors: Karaba AH; Swank Z; Hussain S; Chahoud M; Durand CM; Segev DL; Robien MA; Heeger PS; Larsen CP; Tobian AAR -
Epitope Mapping of SARS-CoV-2 Spike Antibodies in Vaccinated Kidney Transplant Recipients Reveals Poor Spike Coverage Compared to Healthy Controls.
J Infect Dis Volume: 229 Page(s): 1366 - 1371
05/15/2024 Authors: Karaba AH; Morgenlander WR; Johnston TS; Hage C; Pekosz A; Durand CM; Segev DL; Robien MA; Heeger PS; Larsen CP -
Risk factors and outcomes of bloodstream infection from a urinary source in kidney transplant recipients.
Clin Transplant Volume: 38 Page(s): e15279
03/01/2024 Authors: Eichenberger EM; Donzo MW; Anderson R; Karadkhele G; Pouch SM; Larsen CP -
The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005-2021.
Open Forum Infect Dis Volume: 11 Page(s): ofae060
03/01/2024 Authors: Babiker A; Karadkhele G; Bombin A; Watkins R; Robichaux C; Smith G; Beechar VB; Steed DB; Jacob JT; Read TD -
Impact of an ultrasensitive Cytomegalovirus quantitative nucleic acid test on Cytomegalovirus detection and therapy in renal transplant recipients.
Transpl Infect Dis Volume: 26 Page(s): e14219
02/01/2024 Authors: Beechar VB; Pouch SM; Phadke VK; Karadkhele G; Larsen CP; Woodworth MH -
Belatacept with time-limited tacrolimus coimmunosuppression modifies the 3-year risk of eplet mismatch in kidney transplantation.
Am J Transplant Volume: 24 Page(s): 260 - 270
02/01/2024 Authors: Johnson AC; Zhang J; Karadkhele G; Gragert L; Hertzberg V; Larsen CP -
Implications of MHC-restricted immunopeptidome in transplantation.
Front Immunol Volume: 15 Page(s): 1436233
01/01/2024 Authors: Zhanzak Z; Cina D; Johnson AC; Larsen CP -
Costimulatory Blockade and Solid Organ Transplantation: The Past, Present, and Future.
Kidney Int Rep Volume: 8 Page(s): 2529 - 2545
12/01/2023 Authors: Kitchens WH; Larsen CP; Badell IR -
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement.
Sci Transl Med Volume: 15 Page(s): eabo2750
11/01/2023 Authors: Woodworth MH; Conrad RE; Haldopoulos M; Pouch SM; Babiker A; Mehta AK; Sitchenko KL; Wang CH; Strudwick A; Ingersoll JM -
Open letter to Bristol Myers Squibb: Belatacept; we aren't done yet.
Am J Transplant Volume: 23 Page(s): 1483 - 1484
10/01/2023 Authors: Vincenti F; Budde K; Grinyo J; Rostaing L; Kirk AD; Larsen CP -
Letter to the editor: "hook" (prozone) effect in sars-cov-2 anti-spike binding antibody levels following vaccination, infection, or monoclonal antibody in solid organ transplant recipients.
Clin Transplant Volume: 37 Page(s): e15044
08/01/2023 Authors: Abedon AT; Chiang TPY; Karaba AH; Alejo JL; Chahoud M; Hussey C; Lopes JF; Hussain S; Larsen CP; Durand CM -
Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry.
Lancet Diabetes Endocrinol Volume: 11 Page(s): 391 - 401
06/01/2023 Authors: Chetboun M; Drumez E; Ballou C; Maanaoui M; Payne E; Barton F; Kerr-Conte J; Vantyghem M-C; Piemonti L; Rickels MR -
Persistent SARS-CoV-2-specific immune defects in kidney transplant recipients following third mRNA vaccine dose.
Am J Transplant Volume: 23 Page(s): 744 - 758
06/01/2023 Authors: Werbel WA; Karaba AH; Chiang TP-Y; Massie AB; Brown DM; Watson N; Chahoud M; Thompson EA; Johnson AC; Avery RK -
Three-year Outcomes After Conversion From Monthly to Every 2-month Belatacept Maintenance Therapy in Kidney Transplant Recipients: Results From a Randomized Controlled Trial.
Transplant Direct Volume: 9 Page(s): e1449
03/01/2023 Authors: Johnson AC; Karadkhele GM; Shenvi N; Easley KA; Larsen CP; Badell IR -
CD8+ Tcell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor.
Immunity Volume: 56 Page(s): 107 - 124.e5
01/10/2023 Authors: Prokhnevska N; Cardenas MA; Valanparambil RM; Sobierajska E; Barwick BG; Jansen C; Reyes Moon A; Gregorova P; delBalzo L; Greenwald R -
Post-transplant lymphoproliferative disorder risk and outcomes in renal transplant patients treated with belatacept immunosuppression.
Front Transplant Volume: 2 Page(s): 1280993
01/01/2023 Authors: Koff JL; Karadkhele GM; Switchenko JM; Rupji M; Little K; Larsen CP -
Impact of belatacept and tacrolimus on cytomegalovirus viral load control and relapse in moderate and high-risk cytomegalovirus serostatus kidney transplant recipients.
Transpl Infect Dis Volume: 24 Page(s): e13983
12/01/2022 Authors: Magua W; Johnson AC; Karadkhele GM; Badell IR; Vasanth P; Mehta AK; Easley KA; Newell KA; Rickert JB; Larsen CP -
COVID-19 Infection Does Not Alter HLA Antibody Reactivity.
Kidney Int Rep Volume: 7 Page(s): 2279 - 2282
10/01/2022 Authors: Johnson AC; Larsen CP; Gebel H; Bray R -
Biomarker-Based Assessment for Infectious Risk Before and After Heart Transplantation.
Curr Heart Fail Rep Volume: 19 Page(s): 236 - 246
08/01/2022 Authors: Huang AL; Hendren N; Carter S; Larsen C; Garg S; La Hoz R; Farr M -
Great expectations.
Am J Transplant Volume: 22 Page(s): 1735 - 1736
07/01/2022 Authors: Newell KA; Larsen CP -
Longitudinal Characterization of the Microvirome in a Cohort of Renal Transplant Recipients.
Volume: 22 Page(s): 571 - 571
06/01/2022 Authors: Johnson AC; Karadkhele G; Larsen CP -
Immunogenicity of a 3rd Dose of Mrna Covid-19 Vaccine in Kidney Transplant Recipients Who Failed to Respond to 2 Prior Doses.
Volume: 22 Page(s): 640 - 641
06/01/2022 Authors: Werbel W; Karaba A; Chiang T; Liang T; Massie A; Bettinotti M; Clarke W; Watson N; Tobian A; Durand C -
Detection of Alloreactive CD8+T Cell Responses and the Immunopeptidome That Elicits Their Activation.
Volume: 22 Page(s): 543 - 543
06/01/2022 Authors: Morris AB; Zhang X; Peek EV; Hadley A; Larsen C -
Understanding the Modification of Eplet Mismatch Risk by Immunosuppression Regimen
Volume: 22 Page(s): 604 - 604
06/01/2022 Authors: Johnson A; Zhang X; Gragert L; Larsen C -
Longitudinal Evaluation of Cytopenias in the Renal Transplant Population.
Transplant Direct Volume: 8 Page(s): e1339
06/01/2022 Authors: Johnson AC; Karadkhele G; Magua W; Vasanth P; Larsen CP -
Temporal trends and current use of de novo belatacept in kidney transplant recipients in the United States.
Clin Transplant Volume: 36 Page(s): e14531
03/01/2022 Authors: Karadkhele G; Duneton C; Garro R; Badell IR; Pearson TC; Larsen CP; Hogan J -
hlaR: A rapid and reproducible tool to identify eplet mismatches between transplant donors and recipients.
Hum Immunol Volume: 83 Page(s): 248 - 255
03/01/2022 Authors: Johnson AC; Zhang J; Cliff Sullivan H; Wiebe C; Bray R; Gebel H; Larsen CP -
Fecal Microbiota Transplantation Donor Screening Updates and Research Gaps for Solid Organ Transplant Recipients.
J Clin Microbiol Volume: 60 Page(s): e0016121
02/16/2022 Authors: Mehta N; Wang T; Friedman-Moraco RJ; Carpentieri C; Mehta AK; Rouphael N; Dhere T; Larsen CP; Kraft CS; Woodworth MH -
Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection.
Front Immunol Volume: 13 Page(s): 926648
01/01/2022 Authors: Iglesias M; Brennan DC; Larsen CP; Raimondi G -
Progress in kidney transplantation: The role for systems immunology.
Front Med (Lausanne) Volume: 9 Page(s): 1070385
01/01/2022 Authors: Johnson AC; Silva JAF; Kim SC; Larsen CP -
Belatacept in Kidney Transplant Recipients With Failed Allografts for the Prevention of Humoral Sensitization: A Pilot Randomized Controlled Trial.
Transplantation Volume: 105 Page(s): e395 - e396
12/01/2021 Authors: Badell IR; Bray RA; Elbein R; Chami AS; Easley KA; Pastan SO; Guasch A; Gebel HM; Adams AB; Larsen CP -
A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19).
Kidney Int Volume: 100 Page(s): 1303 - 1315
12/01/2021 Authors: May RM; Cassol C; Hannoudi A; Larsen CP; Lerma EV; Haun RS; Braga JR; Hassen SI; Wilson J; VanBeek C -
Belatacept Conversion in Kidney After Liver Transplantation.
Transplant Direct Volume: 7 Page(s): e780
11/01/2021 Authors: Cristea O; Karadkhele G; Kitchens WH; Vasanth P; Larsen CP; Badell IR -
A Roadmap for Innovation to Advance Transplant Access and Outcomes: A Position Statement From the National Kidney Foundation.
Am J Kidney Dis Volume: 78 Page(s): 319 - 332
09/01/2021 Authors: Lentine KL; Pastan S; Mohan S; Reese PP; Leichtman A; Delmonico FL; Danovitch GM; Larsen CP; Harshman L; Wiseman A -
Every 2-month belatacept maintenance therapy in kidney transplant recipients greater than 1-year posttransplant: A randomized, noninferiority trial.
Am J Transplant Volume: 21 Page(s): 3066 - 3076
09/01/2021 Authors: Badell IR; Parsons RF; Karadkhele G; Cristea O; Mead S; Thomas S; Robertson JM; Kim GS; Hanfelt JJ; Pastan SO -
Implications of defective immune responses in SARS-CoV-2 vaccinated organ transplant recipients.
Sci Immunol Volume: 6
07/01/2021 Authors: Heeger PS; Larsen CP; Segev DL -
The Metagenomic Landscape of Renal Transplant
Volume: 21 Page(s): 371 - 371
06/01/2021 Authors: Johnson A; Karadkhele G; Larsen C -
The Microenvironment of Belatacept-Resistant Rejection
Volume: 21 Page(s): 519 - 520
06/01/2021 Authors: Johnson A; Zhang J; Larsen C -
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+T Cells
Volume: 21 Page(s): 542 - 542
06/01/2021 Authors: Morris AB; Peek E; Hadley A; Larsen CP -
Leukopenia in the Renal Transplant Population
Volume: 21 Page(s): 574 - 574
06/01/2021 Authors: Johnson A; Karadkhele G; Larsen C -
COVID-19 in the Kidney Transplant Waitlist Population
Volume: 21 Page(s): 313 - 313
06/01/2021 Authors: Johnson AC; Larsen CP; Gebel H; Bray R -
"hlaR," a Simplified Interface for the HLA Matchmaker Tool
Volume: 21 Page(s): 828 - 828
06/01/2021 Authors: Johnson A; Zhang J; Gebel H; Larsen C -
Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients.
Am J Transplant Volume: 21 Page(s): 1691 - 1698
05/01/2021 Authors: Kirk AD; Adams AB; Durrbach A; Ford ML; Hildeman DA; Larsen CP; Vincenti F; Wojciechowski D; Woodle ES -
Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes.
Am J Transplant Volume: 21 Page(s): 1477 - 1492
04/01/2021 Authors: Markmann JF; Rickels MR; Eggerman TL; Bridges ND; Lafontant DE; Qidwai J; Foster E; Clarke WR; Kamoun M; Alejandro R -
CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation.
Front Immunol Volume: 12 Page(s): 620386
01/01/2021 Authors: Zhang W; Morris AB; Peek EV; Karadkhele G; Robertson JM; Kissick HT; Larsen CP -
CMV high-risk status and posttransplant outcomes in kidney transplant recipients treated with belatacept.
Am J Transplant Volume: 21 Page(s): 208 - 221
01/01/2021 Authors: Karadkhele G; Hogan J; Magua W; Zhang W; Badell IR; Mehta A; Lyon M; Pastan S; Pearson TC; Larsen CP -
Managing COVID-19-positive Solid Organ Transplant Recipients in the Community: What a Community Healthcare Provider Needs to Know.
Transplant Direct Volume: 6 Page(s): e633
12/01/2020 Authors: Basu A; Patzer R; Hosein D; Wang Z; Sharma N; Franch H; Rahbari Oskoui F; Gupta D; Subramanian R; Sridharan L -
Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.
Am J Transplant Volume: 20 Page(s): 3599 - 3608
12/01/2020 Authors: Mannon RB; Armstrong B; Stock PG; Mehta AK; Farris AB; Watson N; Morrison Y; Sarwal M; Sigdel T; Bridges N -
PERFORMANCE OF VIRTUAL CROSSMATCH IN HIGH CPRA PATIENTS
Volume: 81 Page(s): 90 - 90
11/01/2020 Authors: Krummey S; Larsen C; Gebel HM; Bray RA; Sullivan HC -
Long-Term Safety in Epstein-Barr Virus (EBV)-Seropositive Kidney-Only Transplant Recipients Treated with Belatacept (BELA) in Clinical Practice: Final Study Results from the ENLiST Registry
Volume: 20 Page(s): 835 - 836
04/01/2020 Authors: Larsen C; Vincenti F; Kou T; Shadur C; Bresnahan B; Jordan S; Woodle ES; Goes N; Vella J; Wojciechowski D -
Belatacept in Kidney Transplant Recipients with Previous Non-Renal Solid Organ Transplants
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 20 Page(s): 935 - 936
04/01/2020 Authors: Cristea O; Larsen C; Badell I -
Belatacept Provides Superior Inhibition of Donor Specific Antibody Formation in Kidney Transplant Recipients with Acute Rejection
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 20 Page(s): 468 - 468
04/01/2020 Authors: Cristea O; Larsen C; Badell I -
Belatacept Every Two Month Maintenance Dosing in Kidney Transplantation: A Randomized, Non-Inferiority Trial
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 20 Page(s): 445 - 445
04/01/2020 Authors: Badell IR; Parsons R; Mead S; Thomas S; Karadkhele G; Pastan S; Larsen C -
CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence.
Cell Rep Volume: 30 Page(s): 1282 - 1291.e5
02/04/2020 Authors: Krummey SM; Morris AB; Jacobs JR; McGuire DJ; Ando S; Tong KP; Zhang W; Robertson J; Guasch SA; Araki K -
The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients.
Am J Transplant Volume: 20 Page(s): 573 - 581
02/01/2020 Authors: Parsons RF; Zahid A; Bumb S; Decker H; Sullivan HC; Eun-Hyung Lee F; Badell IR; Ford ML; Larsen CP; Pearson TC -
De Novo Belatacept in a Kidney-After-Heart Transplant Recipient.
Transplant Direct Volume: 6 Page(s): e515
01/01/2020 Authors: Schenk AD; Anderson DJ; Cole RT; Badell IR; Larsen CP -
Belatacept and CD28 Costimulation Blockade: Preventing and Reducing Alloantibodies over the Long Term.
Curr Transplant Rep Volume: 6 Page(s): 277 - 284
12/01/2019 Authors: Parsons RF; Larsen CP; Pearson TC; Badell IR -
Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion.
Am J Transplant Volume: 19 Page(s): 2174 - 2185
08/01/2019 Authors: Kim SC; Mathews DV; Breeden CP; Higginbotham LB; Ladowski J; Martens G; Stephenson A; Farris AB; Strobert EA; Jenkins J -
Abatacept as rescue immunosuppression after calcineurin inhibitor treatment failure in renal transplantation.
Am J Transplant Volume: 19 Page(s): 2342 - 2349
08/01/2019 Authors: Badell IR; Karadkhele GM; Vasanth P; Farris AB; Robertson JM; Larsen CP -
Establishing a Core Outcome Measure for Life Participation: A Standardized Outcomes in Nephrology-kidney Transplantation Consensus Workshop Report.
Transplantation Volume: 103 Page(s): 1199 - 1205
06/01/2019 Authors: Ju A; Josephson MA; Butt Z; Jowsey-Gregoire S; Tan J; Taylor Q; Fowler K; Dobbels F; Caskey F; Jha V -
Patient Navigators in Transplantation-Where Do We Go From Here?
Transplantation Volume: 103 Page(s): 1076 - 1077
06/01/2019 Authors: Patzer RE; Larsen CP -
Corticosteroids and methotrexate as adjuvants to costimulation blockade in non-human primate renal transplantation.
Clin Transplant Volume: 33 Page(s): e13568
06/01/2019 Authors: Anderson DJ; Lo DJ; Leopardi F; Song M; Strobert EA; Jenkins JB; Larsen CP; Kirk AD -
Reduction of Pre-Existing Alloantibodies in Highly Sensitized Belatacept-Treated Kidney Recipients.
Volume: 19 Page(s): 810 - 810
04/01/2019 Authors: Parsons RF; Bumb S; Decker H; Zahid A; Sullivan C; Pearson T; Larsen C; Levine M; Kamoun M; Bray RA -
Abatacept as Rescue Immunosuppression after Calcineurin Inhibitor Treatment Failure in Renal Transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 19 Page(s): 690 - 690
04/01/2019 Authors: Badell IR; Vasanth P; Farris AB; Robertson JM; Karadkhele GM; Larsen CP -
Belatacept Monotherapy in Kidney Transplant Recipients with Failed Allografts Reduces Humoral Sensitization in a Single Center Randomized Controlled Trial.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 19 Page(s): 450 - 450
04/01/2019 Authors: Badell IR; Elbein R; Bray RA; Gebel HM; Adams AB; Larsen CP -
CMV Risk Status Remains a Relevant Risk Factor for Long-Term Outcomes.
Volume: 19 Page(s): 316 - 317
04/01/2019 Authors: Karadkhele G; Zhang W; Larsen CP -
Impact of Cytomegalovirus on the Immune System of Healthy Humans.
Volume: 19 Page(s): 339 - 340
04/01/2019 Authors: Zhang W; Robertson J; Karadkhele G; Johnson B; Larsen C -
Kinetics of antibody response to influenza vaccination in renal transplant recipients.
Transpl Immunol Volume: 53 Page(s): 51 - 60
04/01/2019 Authors: Gangappa S; Wrammert J; Wang D; Li Z-N; Liepkalns JS; Cao W; Chen J; Levine MZ; Stevens J; Sambhara S -
The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms.
Am J Med Sci Volume: 356 Page(s): 433 - 440
11/01/2018 Authors: Gopalsamy SN; Woodworth MH; Wang T; Carpentieri CT; Mehta N; Friedman-Moraco RJ; Mehta AK; Larsen CP; Kraft CS -
CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.
J Clin Invest Volume: 128 Page(s): 4557 - 4572
10/01/2018 Authors: Mathews DV; Dong Y; Higginbotham LB; Kim SC; Breeden CP; Stobert EA; Jenkins J; Tso JY; Larsen CP; Adams AB -
Patient Navigators in Transplantation - where do we go from here?
Transplantation
09/11/2018 Authors: Patzer RE; Larsen CP -
Effect of the iChoose Kidney decision aid in improving knowledge about treatment options among transplant candidates: A randomized controlled trial.
Am J Transplant Volume: 18 Page(s): 1954 - 1965
08/01/2018 Authors: Patzer RE; McPherson L; Basu M; Mohan S; Wolf M; Chiles M; Russell A; Gander JC; Friedewald JJ; Ladner D -
Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT-EXT.
Am J Transplant Volume: 18 Page(s): 1774 - 1782
07/01/2018 Authors: Bray RA; Gebel HM; Townsend R; Roberts ME; Polinsky M; Yang L; Meier-Kriesche H-U; Larsen CP -
De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies.
Am J Transplant Volume: 18 Page(s): 1783 - 1789
07/01/2018 Authors: Bray RA; Gebel HM; Townsend R; Roberts ME; Polinsky M; Yang L; Meier-Kriesche H-U; Larsen CP -
Transplant Center Patient Navigator and Access to Transplantation among High-Risk Population: A Randomized, Controlled Trial.
Clin J Am Soc Nephrol Volume: 13 Page(s): 620 - 627
04/06/2018 Authors: Basu M; Petgrave-Nelson L; Smith KD; Perryman JP; Clark K; Pastan SO; Pearson TC; Larsen CP; Paul S; Patzer RE -
Emergency department use among kidney transplant recipients in the United States.
Volume: 18 Page(s): 868 - 880
04/01/2018 Authors: Lovasik BP; Zhang R; Hockenberry JM; Schrager JD; Pastan SO; Adams AB; Mohan S; Larsen CP; Patzer RE -
Outcomes at 7years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT.
Clin Transplant Volume: 32 Page(s): e13225
04/01/2018 Authors: Florman S; Vincenti F; Durrbach A; Abouljoud M; Bresnahan B; Garcia VD; Mulloy L; Rice K; Rostaing L; Zayas C -
POST-TRANSPLANT REDUCTION IN PRE-EXISTING DONOR-SPECIFIC ANTIBODY LEVELS AFTER BELATACEPT-VS CYCLOSPORINE-BASED IMMUNOSUPPRESSION
Volume: 31 Page(s): 20 - 21
01/01/2018 Authors: Bray R; Gebel H; Townsend R; Polinsky M; Yang L; Meier-Kriesche U; Larsen C -
Ten-year outcomes in a randomized phase II study of kidney transplant recipients administered belatacept 4-weekly or 8-weekly.
Am J Transplant Volume: 17 Page(s): 3219 - 3227
12/01/2017 Authors: Vincenti F; Blancho G; Durrbach A; Grannas G; Griny J; Meier-Kriesche H-U; Polinsky M; Yang L; Larsen CP -
Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function.
Am J Transplant Volume: 17 Page(s): 2922 - 2936
11/01/2017 Authors: Adams AB; Goldstein J; Garrett C; Zhang R; Patzer RE; Newell KA; Turgeon NA; Chami AS; Guasch A; Kirk AD -
Lessons Learned: Early Termination of a Randomized Trial of Calcineurin Inhibitor and Corticosteroid Avoidance Using Belatacept.
Am J Transplant Volume: 17 Page(s): 2712 - 2719
10/01/2017 Authors: Newell KA; Mehta AK; Larsen CP; Stock PG; Farris AB; Mehta SG; Ikle D; Armstrong B; Morrison Y; Bridges N -
CD4 depletion is necessary and sufficient for long-term pig-to-nonhuman primate renal xenotransplant survival
Volume: 24
09/01/2017 Authors: Kim S; Higginbotham LB; Mathews DV; Breeden C; Dong Y; Stephenson A; Larsen CP; Ford M; Tector J; Adams AB -
CD28 directed immunotherapy is more potent than belatacept in a pig-to-nonhuman primate renal xenotransplant model
Volume: 24
09/01/2017 Authors: Kim S; Higginbotham L; Mathews DV; Breeden C; Stephenson A; Larsen CP; Ford M; Tector J; Adams AB -
FACTORS ASSOCIATED WITH USAGE OF A WEB-BASED PATIENT PORTAL AMONG KIDNEY AND LIVER TRANSPLANT RECIPIENTS
Volume: 30 Page(s): 97 - 98
09/01/2017 Authors: Ruiz A; Patzer R; Smith K; Little K; Pastan S; Larsen C; Wedd J -
Increased Pretransplant Frequency of CD28+ CD4+ TEM Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients.
Am J Transplant Volume: 17 Page(s): 2350 - 2362
09/01/2017 Authors: Cortes-Cerisuelo M; Laurie SJ; Mathews DV; Winterberg PD; Larsen CP; Adams AB; Ford ML -
Belatacept-Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells.
Am J Transplant Volume: 17 Page(s): 2285 - 2299
09/01/2017 Authors: Mathews DV; Wakwe WC; Kim SC; Lowe MC; Breeden C; Roberts ME; Farris AB; Strobert EA; Jenkins JB; Larsen CP -
Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.
Am J Transplant Volume: 17 Page(s): 1182 - 1192
05/01/2017 Authors: Kim SC; Wakwe W; Higginbotham LB; Mathews DV; Breeden CP; Stephenson AC; Jenkins J; Strobert E; Price K; Price L -
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model
Volume: 17 Page(s): 343 - 343
04/01/2017 Authors: Kim S; Mathews D; Higginbotham L; Breeden C; Larsen C; Adams A -
Post-Transplant Reduction in Pre-Existing Donor-Specific Antibody Levels After Belatacept-vs Cyclosporine-Based Immunosuppression
Volume: 17 Page(s): 267 - 268
04/01/2017 Authors: Bray R; Gebel H; Townsend R; Polinsky M; Yang L; Meier-Kriesche U; Larsen C -
High CTLA-4 Expression and Diminished FOXO3 Expression Underlie Differential CD28 Signaling on Human Memory Th17 Cells
Volume: 17 Page(s): 272 - 272
04/01/2017 Authors: Krummey S; Suchard S; Nadler S; Larsen C; Ford M -
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival
Volume: 17 Page(s): 374 - 374
04/01/2017 Authors: Kim S; Higginbotham L; Mathews D; Breeden C; Stephenson A; Larsen C; Ford M; Tector J; Adams A -
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model
Volume: 17 Page(s): 374 - 375
04/01/2017 Authors: Kim S; Higginbotham L; Mathews D; Breeden C; Stephenson A; Larsen C; Ford M; Tector J; Adams A -
Race, Admissions, and Renal Transplant Waitlisting.
Volume: 17 Page(s): 809 - 809
04/01/2017 Authors: Lynch R; Zhang R; Patzer R; Larsen C; Adams A -
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept
Volume: 17 Page(s): 735 - 735
04/01/2017 Authors: Kitchens W; Farris A; Pastan S; Pearson T; Larsen C; Adams A -
First-Year Waitlist Hospitalization and Subsequent Waitlist and Transplant Outcome.
Am J Transplant Volume: 17 Page(s): 1031 - 1041
04/01/2017 Authors: Lynch RJ; Zhang R; Patzer RE; Larsen CP; Adams AB -
Interruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection.
JCI Insight Volume: 2 Page(s): e90317
03/09/2017 Authors: Kitchens WH; Dong Y; Mathews DV; Breeden CP; Strobert E; Fuentes ME; Larsen CP; Ford ML; Adams AB -
The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
Am J Transplant Volume: 17 Page(s): 657 - 670
03/01/2017 Authors: Zheng HB; Watkins B; Tkachev V; Yu S; Tran D; Furlan S; Zeleski K; Singh K; Hamby K; Hotchkiss C -
ACUTE REJECTION BY BELATACEPT 4-VS 8-WEEK DOSING: PHASE II STUDY 10-YEAR RESULTS
TRANSPLANT INTERNATIONAL Volume: 30 Page(s): 6 - 6
01/01/2017 Authors: Vicenti F; Blancho G; Durrbach A; Grannas G; Grinyo J; Meier-Kriesche U; Polinsky M; Zhao H; Larsen CP -
Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT-EXT at 7 Years After Transplant.
Am J Transplant Volume: 17 Page(s): 180 - 190
01/01/2017 Authors: Florman S; Becker T; Bresnahan B; Chevaile-Ramos A; Carvalho D; Grannas G; Muehlbacher F; O'Connell PJ; Meier-Kriesche HU; Larsen CP -
Waitlist Hospital Admissions Predict Resource Utilization and Survival After Renal Transplantation.
Ann Surg Volume: 264 Page(s): 1168 - 1173
12/01/2016 Authors: Lynch RJ; Zhang R; Patzer RE; Larsen CP; Adams AB -
REDUCED INCIDENCE AND LEVEL OF DE NOVO DONOR-SPECIFIC ANTIBODIES IN BELATACEPT-TREATED VS. CYCLOSPORINE-TREATED PATIENTS: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 29 Page(s): 11 - 12
10/01/2016 Authors: Bray R; Gebel H; Townsend R; Polinsky M; Yang L; Meier-Kriesche U; Larsen C -
ACUTE REJECTION BY BELATACEPT DOSING FREQUENCY: RESULTS FROM A PHASE II STUDY OF KIDNEY TRANSPLANT RECIPIENTS
TRANSPLANT INTERNATIONAL Volume: 29 Page(s): 9 - 9
10/01/2016 Authors: Vincenti F; Blancho G; Durrbach A; Grannas G; Grinyo J; Meier-Kriesche U; Polinsky M; Zhao H; Larsen C -
Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway.
J Immunol Volume: 197 Page(s): 2045 - 2050
09/15/2016 Authors: Adams AB; Ford ML; Larsen CP -
Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity.
J Immunol Volume: 197 Page(s): 2009 - 2015
09/01/2016 Authors: Krummey SM; Chen C-W; Guasch SA; Liu D; Wagener M; Larsen CP; Ford ML -
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.
Diabetes Care Volume: 39 Page(s): 1230 - 1240
07/01/2016 Authors: Hering BJ; Clarke WR; Bridges ND; Eggerman TL; Alejandro R; Bellin MD; Chaloner K; Czarniecki CW; Goldstein JS; Hunsicker LG -
Post-Trial Experience with Belatacept: A Large Single Center Experience.
Volume: 16 Page(s): 741 - 741
06/01/2016 Authors: Adams A; Garrett C; Goldstein J; Zhang R; Guasch A; Pastan S; Patzer R; Kirk A; Pearson T; Larsen C -
A Pathway to Belatacept Monotherapy: Alemtuzumab, Belatacept and Rapamycin for Kidney Transplantation.
Volume: 16 Page(s): 303 - 303
06/01/2016 Authors: Guasch A; Xu H; Mehta A; Ghali A; Mead S; Gebel H; Bray R; Larsen C; Pearson T; Kirk A -
Outcomes in Black vs Non-Black Patients Administered Belatacept (Bela) or Cyclosporine (CsA) in BENEFIT.
Volume: 16 Page(s): 743 - 743
06/01/2016 Authors: Vincenti F; Medina Pestana J; Abouljoud M; Bresnahan B; Garcia VD; Mulloy L; Rice K; Rostaing L; Zayas C; Calderon K -
Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation
Volume: 16 Page(s): 406 - 406
06/01/2016 Authors: Higginbotham L; Kim S; Mathews D; Stephenson A; Breeden C; Larsen C; Ford M; Newell K; Tector A; Adams A -
Acute Rejection in Non-Human Primates Treated with Belatacept Is Mediated by a Unique CD8 Memory Subset.
Volume: 16 Page(s): 205 - 206
06/01/2016 Authors: Mathews D; Wakwe W; Lowe M; Breeden C; Leopardi F; Farris A; Song M; Strobert E; Jenkins J; Larsen C -
Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.
Volume: 16 Page(s): 741 - 741
06/01/2016 Authors: Vincenti F; Blancho G; Durrbach A; Grannas G; Griny J; Meier-Kriesche U; Polinsky M; Zhao H; Larsen C -
Reduced Incidence and Level of De Novo Donor-Specific Antibodies in Belatacept-Treated vs. Cyclosporine-Treated Patients: Final Results from BENEFIT.
Volume: 16 Page(s): 742 - 742
06/01/2016 Authors: Bray R; Gebel H; Townsend R; Polinsky M; Yang L; Meier-Kriesche U; Larsen C -
Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection.
Am J Transplant Volume: 16 Page(s): 1456 - 1464
05/01/2016 Authors: Anderson DJ; Lo DJ; Leopardi F; Song M; Turgeon NA; Strobert EA; Jenkins JB; Wang R; Reimann KA; Larsen CP -
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
J Immunol Volume: 196 Page(s): 2838 - 2846
03/15/2016 Authors: Krummey SM; Martinez RJ; Andargachew R; Liu D; Wagener M; Kohlmeier JE; Evavold BD; Larsen CP; Ford ML -
iChoose Kidney: A Clinical Decision Aid for Kidney Transplantation Versus Dialysis Treatment.
Transplantation Volume: 100 Page(s): 630 - 639
03/01/2016 Authors: Patzer RE; Basu M; Larsen CP; Pastan SO; Mohan S; Patzer M; Konomos M; McClellan WM; Lea J; Howard D -
LONG-TERM SURVIVAL OUTCOMES IN BELATACEPT-TREATED VS CYCLOSPORINE-TREATED PATIENTS: FINAL RESULTS FROM BENEFIT-EXT
TRANSPLANT INTERNATIONAL Volume: 29 Page(s): 8 - 8
02/01/2016 Authors: Durrbach A; Bray R; Gebel H; Florman S; Kuypers D; Larsen CP; Pestana JM; Del Carmen Rial M; Rostaing L; Wekerle T -
BELATACEPT-TREATED PATIENTS HAD SUPERIOR GRAFT SURVIVAL COMPARED WITH CYCLOSPORINE-TREATED PATIENTS: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 29 Page(s): 8 - 8
02/01/2016 Authors: Vincenti F; Bray R; Gebel H; Grinyo J; Moal MC; Rice K; Rostaing L; Steinberg S; Meier-Kriesche U; Polinsky M -
Belatacept and Long-Term Outcomes in Kidney Transplantation.
N Engl J Med Volume: 374 Page(s): 333 - 343
01/28/2016 Authors: Vincenti F; Rostaing L; Grinyo J; Rice K; Steinberg S; Gaite L; Moal M-C; Mondragon-Ramirez GA; Kothari J; Polinsky MS -
Long-Term Survival Outcomes in Belatacept-Treated vs. Cyclosporine-Treated Patients: Final Results From BENEFIT-EXT
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 16 Page(s): 45 - 45
01/01/2016 Authors: Florman S; Bray R; Gebel H; Kuypers D; Larsen C; Medina Pestana J; Rial M; Rostaing L; Wekerle T; Grannas G -
Belatacept-Treated Patients Had Superior Graft Survival vs. Cyclosporine-Treated Patients: Final Results From BENEFIT F
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 16 Page(s): 44 - 44
01/01/2016 Authors: Vincenti F; Grinyo J; Bray R; Rostaing L; Bresnahan B; Rice K; Steinberg S; Gebel H; Polinsky M; Meier-Kriesche U -
Pathogen Stimulation History Impacts Donor-Specific CD8(+) T Cell Susceptibility to Costimulation/Integrin Blockade-Based Therapy.
Am J Transplant Volume: 15 Page(s): 3081 - 3094
12/01/2015 Authors: Badell IR; Kitchens WH; Wagener ME; Lukacher AE; Larsen CP; Ford ML -
Belatacept-treated patients had superior graft survival compared with cyclosporine-treated patients: final results from BENEFIT
Volume: 145 Page(s): 10S - 11S
11/12/2015 Authors: Vincenti F; Bray R; Gebel H; Grinyo J; Moal M-C; Rice K; Rostaing L; Steinberg S; Meier-Kriesche U; Polinsky M -
Long-term survival outcomes in belatacept-treated vs cyclosporine-treated patients: final results from BENEFIT-EXT
Volume: 145 Page(s): 41S - 41S
11/12/2015 Authors: Durrbach A; Bray R; Gebel H; Florman S; Kuypers D; Larsen CP; Pestana JM; Del Carmen Rial M; Rostaing L; Wekerle T -
Long-term survival of pig-to-primate renal xenotransplant using costimulation-blockade immunosuppression
Volume: 22 Page(s): S45 - S45
11/01/2015 Authors: Higginbotham L; Mathews D; Stephenson A; Breeden C; Larsen CP; Ford ML; Newell KA; Tector J; Adams AB -
EVALUATION OF DONOR-SPECIFIC ANTIBODIES THROUGH 7 YEARS WITH BELATACEPT: FINAL RESULTS FROM BENEFIT-EXT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 82 - 82
11/01/2015 Authors: Meier-Kriesche H-U; Bray R; Gebel H; Townsend R; Larsen C -
BELATACEPT PATIENTS HAD SUPERIOR GRAFT SURVIVAL COMPARED WITH CYCLOSPORINE PATIENTS: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 81 - 81
11/01/2015 Authors: Vincenti F; Grinyo J; Rostaing L; Rice K; Steinberg S; Moal M-C; Polinsky M; Meier-Kriesche H-U; Larsen C -
DONOR-SPECIFIC ANTIBODY RATES ACROSS 7 YEARS OF TREATMENT WITH BELATACEPT: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 242 - 242
11/01/2015 Authors: Meier-Kriesche H-U; Bray R; Gebel H; Townsend R; Larsen C -
LONG-TERM SURVIVAL OF PIG-TO-PRIMATE RENAL XENOTRANSPLANT USING COSTIMULATION-BLOCKADE IMMUNOSUPPRESSION.
Volume: 99 Page(s): S72 - S73
11/01/2015 Authors: Higginbotham L; Mathews D; Stephenson A; Breeden C; Larsen CP; Ford ML; Newell KA; Tector J; Adams AB -
BELATACEPT-TREATED PATIENTS HAD SUPERIOR GRAFT SURVIVAL COMPARED WITH CYCLOSPORINE-TREATED PATIENTS: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 51 - 51
10/01/2015 Authors: Vincenti F; Grinyo J; Moal M-C; Rice K; Rostaing L; Steinberg S; Meier-Kriesche U; Polinsky M; Larsen CP -
LONG-TERM SURVIVAL OUTCOMES IN BELATACEPT-TREATED VS. CYCLOSPORINE-TREATED PATIENTS: FINAL RESULTS FROM BENEFIT-EXT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 10 - 10
10/01/2015 Authors: Durrbach A; Bray R; Gebel H; Florman S; Kuypers D; Larsen CP; Pestana JM; del Carmen Rial M; Rostaing L; Wekerle T -
BELATACEPT PATIENTS HAD SUPERIOR GRAFT SURVIVAL COMPARED WITH CYCLOSPORINE PATIENTS: FINAL RESULTS FROM BENEFIT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 10 - 10
10/01/2015 Authors: Vincenti F; Bray R; Gebel H; Grinyo J; Moal M-C; Rice K; Rostaing L; Steinberg S; Meier-Kriesche U; Polinsky M -
Ebola Virus Disease: Experience and Decision Making for the First Patients outside of Africa.
PLoS Med Volume: 12 Page(s): e1001857
07/01/2015 Authors: Stephens DS; Ribner BS; Gartland BD; Feistritzer NR; Farley MM; Larsen CP; Fox JT -
Anti-CD122+Costimulation Blockade Prolongs Allograft Survival
Volume: 15
05/01/2015 Authors: Mathews D; Higginbotham L; Dong Y; Breeden C; Larsen C; Tso J; Adams A -
Deceased Donor Kidney Transplantation Without Calcineurin Inhibitors or Steroids
Volume: 15
05/01/2015 Authors: Kirk A; Guasch A; Mead S; Ghali A; Mehta A; Gebel H; Bray R; Larsen C; Pearson T -
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+T Cells During Heterologous Immunity
Volume: 15
05/01/2015 Authors: Krummey S; Chen C-W; Liu D; Wagener M; Evavold B; Larsen C; Ford M -
Immune Phenotyping of Peripheral Blood Samples from the CTOT-10 Belatacept Study
Volume: 15
05/01/2015 Authors: Suessmuth Y; Stempora L; Johnson B; Cheeseman J; Morrison Y; Bridges N; Ikle D; Tomlanovich S; Stock P; Mannon R -
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated With Belatacept
Volume: 15
05/01/2015 Authors: Kitchens W; Farris A; Pastan S; Pearson T; Larsen C; Adams A -
CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model
Volume: 15
05/01/2015 Authors: Higginbotham L; Mathews D; Breeden C; Wakwe W; Larsen C; Nadler S; Adams A -
Belatacept-Treated Patients Had Better Graft Survival at 7-Years Post-Transplant Compared With Cyclosporine-Treated Patients: Final Results from BENEFIT
Volume: 15
05/01/2015 Authors: Vincenti F; Grinyo J; Rostaing L; Rice K; Steinberg S; Moal M; Polinsky M; Meier-Kriesche U; Larsen C -
Evaluation of Donor-Specific Antibodies Through 7 Years With Belatacept in BENEFIT and BENEFIT-EXT
Volume: 15
05/01/2015 Authors: Bray R; Gebel H; Townsend R; Meier-Kriesche U; Larsen C -
Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
Am J Transplant Volume: 15 Page(s): 1241 - 1252
05/01/2015 Authors: Martin BM; Samy KP; Lowe MC; Thompson PW; Cano J; Farris AB; Song M; Dove CR; Leopardi FV; Strobert EA -
A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation.
Volume: 15 Page(s): 984 - 992
04/01/2015 Authors: Lo DJ; Anderson DJ; Song M; Leopardi F; Farris AB; Strobert E; Chapin S; Devens B; Karrer E; Kirk AD -
Prehospital use of magnesium sulfate as neuroprotection in acute stroke.
N Engl J Med Volume: 372 Page(s): 528 - 536
02/05/2015 Authors: Saver JL; Starkman S; Eckstein M; Stratton SJ; Pratt FD; Hamilton S; Conwit R; Liebeskind DS; Sung G; Kramer I -
FINAL RESULTS FROM THE LONG-TERM EXTENSION (LTE) OF THE BELATACEPT PHASE 2 STUDY IN KIDNEY TRANSPLANTATION
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 7 - 7
01/01/2015 Authors: Charpentier B; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Grannas G; Meier-Kriesche U; Vincenti F -
EVALUATION OF DONOR-SPECIFIC ANTIBODIES THROUGH 5 YEARS WITH BELATACEPT IN BENEFIT AND BENEFIT-EXT
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 7 - 7
01/01/2015 Authors: Meier-Kriesche U; Bray R; Gebel H; Brannon P; Ganguly B; Townsend R; Harler MB; Larsen C -
OUTCOMES AT 3-YEARS IN EBV plus RECIPIENTS OF DECEASED DONOR KIDNEYS FROM TWO RANDOMIZED TRIALS (BENEFIT AND BENEFIT EXT) COMPARING BELATACEPT VERSUS CYCLOSPORINE
TRANSPLANT INTERNATIONAL Volume: 28 Page(s): 7 - 7
01/01/2015 Authors: Durrbach A; Muehlbacher F; Florman S; Pestana JM; Harler MB; Larsen C -
Final Results from the Long-Term Extension (LTE) of the Belatacept Phase 2 Study in Kidney Transplantation
Volume: 15 Page(s): 58 - 58
01/01/2015 Authors: Vincenti F; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Grannas G; Meier-Kriesche U; Charpentier B -
Consideration of Waitlist Performance Can Improve Renal Transplant Readmission and Survival
Volume: 15 Page(s): 74 - 74
01/01/2015 Authors: Lynch R; Zhang R; Patzer R; Larsen C; Adams A -
Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model.
Xenotransplantation Volume: 22 Page(s): 221 - 230
01/01/2015 Authors: Higginbotham L; Mathews D; Breeden CA; Song M; Farris AB; Larsen CP; Ford ML; Lutz AJ; Tector M; Newell KA -
Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
Am J Transplant Volume: 14 Page(s): 2691 - 2703
12/01/2014 Authors: Singh K; Stempora L; Harvey RD; Kirk AD; Larsen CP; Blazar BR; Kean LS -
Final Results from the Long-term Extension (LTE) of the Belatacept Phase 2 Study in Kidney Transplantation
Volume: 144 Page(s): 4S - 5S
11/19/2014 Authors: Vincenti F; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Grannas G; Meier-Kriesche U; Charpentier B -
Outcomes at 3-years in EBV plus Recipients of Deceased Donor Kidneys from Two Randomized Trials (BENEFIT and BENEFIT EXT) Comparing Belatacept vs Cyclosporine
Volume: 144 Page(s): 23S - 23S
11/19/2014 Authors: Muehlbacher F; Durrbach A; Florman S; Pestana JM; Harler MB; Larsen C -
FINAL RESULTS FROM THE LONG-TERM EXTENSION (LTE) OF THE BELATACEPT PHASE 2 STUDY IN KIDNEY TRANSPLANTATION
TRANSPLANT INTERNATIONAL Volume: 27 Page(s): 22 - 22
10/01/2014 Authors: Grannas G; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Charpentier B; Jones-Burton C; Vincenti F -
CONCLUDING RESULTS OF THE LONG-TERM PHASE-2 EXTENSION STUDY (LTE) WITH BELATACEPT AFTER KIDNEY TRANSPLANT
TRANSPLANT INTERNATIONAL Volume: 27 Page(s): 23 - 23
10/01/2014 Authors: Muehlbacher F; Larsen C; Grinyo J; Charpentier B; Blancho G; Grannas G; Jones-Burton C; Vincenti F -
3-ANNUAL-RESULTS OF TWO RANDOMIZED STUDIES (BENEFIT AND BENEFIT EXT) WITH EBV-POSITIVE RECIEVERS OF KIDNEY TRANSPLANTS DECEASED DONOR, IN WHICH BELATACEPT CYCLOSPORIN WITH COMPARED
TRANSPLANT INTERNATIONAL Volume: 27 Page(s): 22 - 23
10/01/2014 Authors: Muehlbacher F; Durrbach A; Florman S; Medina Pestana J; Harler MB; Larsen C -
Alemtuzumab, Belatacept and Sirolimus: A Path to Monotherapy Belatacept
Volume: 98 Page(s): 80 - 80
07/15/2014 Authors: Kirk A; Guasch A; Xu H; Cheeseman J; Mead S; Ghali A; Mehta A; Gebel H; Bray R; Horan J -
Final Results From the Long-Term Extension (LTE) of the Belatacept Phase 2 Study in Kidney Transplantation.
Volume: 98 Page(s): 117 - 117
07/15/2014 Authors: Charpentier B; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Grannas G; Jones-Burton C; Vincenti F -
Pre-Clinical Evaluation of a Novel Domain Antibody Targeting CD154 in a Non-Human Primate Transplant Model.
Volume: 98 Page(s): 680 - 681
07/15/2014 Authors: Wakwe W; Breeden C; Leopardi F; Farris A; Song M; Strobert E; Jenkins J; Price K; Nadler S; Larsen C -
Evaluation of Donor-Specific Antibodies Through 5 Years With Belatacept in BENEFIT and BENEFIT-EXT.
Volume: 98 Page(s): 117 - 117
07/15/2014 Authors: Bray R; Gebel H; Brannon P; Ganguly B; Townsend R; Meier-Kriesche U; Harler M; Larsen C -
Investigating The Functional Role of CD28 On Belatacept-Resistant Human TH17 Memory Cells.
Volume: 98 Page(s): 312 - 312
07/15/2014 Authors: Krummey S; Gaville C; Cheeseman J; Conger J; Jang P; Suchard S; Boise L; Nadler S; Kirk A; Larsen C -
LFA-1 Blockade in a Primarily Vascularized Primate Allograft Model of Costimulation Blockade Resistant Rejection
Volume: 98 Page(s): 288 - 288
07/15/2014 Authors: Anderson D; Lo D; Leopardi F; Turgeon N; Strobert E; Jenkins J; Li J; Wang R; Reimann K; Larsen C -
Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity
Volume: 98 Page(s): 33 - 33
07/15/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M -
Leukotoxin Selectively Kills NK and Effector Memory T Cells
Volume: 98 Page(s): 288 - 288
07/15/2014 Authors: Anderson D; Lo D; Strobert E; Kachlany S; Larsen C; Kirk A -
Outcomes at 3-Years in EBV plus Recipients of Deceased Donor Kidneys From Two Randomized Trials (BENEFIT and BENEFIT EXT) Comparing Belatacept vs Cyclosporine
Volume: 98 Page(s): 455 - 455
07/15/2014 Authors: Muehlbacher F; Durrbach A; Florman S; Medina Pestana J; Harler M; Larsen C -
Final Results From the Long-Term Extension (LTE) of the Belatacept Phase 2 Study in Kidney Transplantation.
Volume: 14 Page(s): 117 - 117
06/01/2014 Authors: Charpentier B; Larsen C; Grinyo J; Muehlbacher F; Blancho G; Grannas G; Jones-Burton C; Vincenti F -
Evaluation of Donor-Specific Antibodies Through 5 Years With Belatacept in BENEFIT and BENEFIT-EXT
Volume: 14 Page(s): 117 - 117
06/01/2014 Authors: Bray R; Gebel H; Brannon P; Ganguly B; Townsend R; Meier-Kriesche U; Harler M; Larsen C -
Investigating The Functional Role of CD28 On Belatacept-Resistant Human TH17 Memory Cells
Volume: 14 Page(s): 312 - 312
06/01/2014 Authors: Krummey S; Gaville C; Cheeseman J; Conger J; Jang P; Suchard S; Boise L; Nadler S; Kirk A; Larsen C -
Outcomes at 3-Years in EBV plus Recipients of Deceased Donor Kidneys From Two Randomized Trials (BENEFIT and BENEFIT EXT) Comparing Belatacept vs Cyclosporine
Volume: 14 Page(s): 455 - 455
06/01/2014 Authors: Muehlbacher F; Durrbach A; Florman S; Medina Pestana J; Harler M; Larsen C -
LFA-1 Blockade in a Primarily Vascularized Primate Allograft Model of Costimulation Blockade Resistant Rejection.
Volume: 14 Page(s): 288 - 288
06/01/2014 Authors: Anderson D; Lo D; Leopardi F; Turgeon N; Strobert E; Jenkins J; Li J; Wang R; Reimann K; Larsen C -
Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity.
Volume: 14 Page(s): 33 - 33
06/01/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M -
Pre-Clinical Evaluation of a Novel Domain Antibody Targeting CD154 in a Non-Human Primate Transplant Model.
Volume: 14 Page(s): 680 - 681
06/01/2014 Authors: Wakwe W; Breeden C; Leopardi F; Farris A; Song M; Strobert E; Jenkins J; Price K; Nadler S; Larsen C -
Alemtuzumab, Belatacept and Sirolimus: A Path to Monotherapy Belatacept
Volume: 14 Page(s): 80 - 80
06/01/2014 Authors: Kirk A; Guasch A; Xu H; Cheeseman J; Mead S; Ghali A; Mehta A; Gebel H; Bray R; Horan J -
Leukotoxin Selectively Kills NK and Effector Memory T Cells.
Volume: 14 Page(s): 288 - 288
06/01/2014 Authors: Anderson D; Lo D; Strobert E; Kachlany S; Larsen C; Kirk A -
Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.
Am J Transplant Volume: 14 Page(s): 1142 - 1151
05/01/2014 Authors: Kirk AD; Guasch A; Xu H; Cheeseman J; Mead SI; Ghali A; Mehta AK; Wu D; Gebel H; Bray R -
High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.
Am J Transplant Volume: 14 Page(s): 607 - 614
03/01/2014 Authors: Krummey SM; Cheeseman JA; Conger JA; Jang PS; Mehta AK; Kirk AD; Larsen CP; Ford ML -
The Spectrum of Alloimmunity, Heterologous Immunity, and Relevant Autoimmunity
Page(s): 87 - 98
01/01/2014 Authors: Ford ML; Adams AB; Larsen CP -
Redefining Readmission in Renal Transplantation -- Variation in Resource Utilization and Outcome
Volume: 14 Page(s): 81 - 81
01/01/2014 Authors: Lynch R; Byrd J; Patzer R; Larsen C; Adams A -
Patterns of Hospital Admissions Before and After Renal Transplantation_Lessons for New Quality Paradigms
Volume: 14 Page(s): 80 - 81
01/01/2014 Authors: Lynch R; Byrd J; Patzer R; Larsen C; Adams A -
LONG-TERM BELATACEPT MAINTAINS EFFICACY AND SAFETY: 5-YEAR BENEFIT LONG-TERM EXTENSION (LTE) RESULTS
TRANSPLANT INTERNATIONAL Volume: 26 Page(s): 2 - 3
12/01/2013 Authors: Rostaing L; Vincenti F; Grinyo JM; Rice KM; Steinberg SM; Gaite LE; Moal MC; Pupim L; Larsen CP -
Long-term belatacept exposure maintains efficacy and safety at 5 years: results from the long-term extension of the BENEFIT study.
Am J Transplant Volume: 13 Page(s): 2875 - 2883
11/01/2013 Authors: Rostaing L; Vincenti F; Griny J; Rice KM; Bresnahan B; Steinberg S; Gang S; Gaite LE; Moal M-C; Mondragn-Ramirez GA -
In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial.
Biol Blood Marrow Transplant Volume: 19 Page(s): 1638 - 1649
11/01/2013 Authors: Koura DT; Horan JT; Langston AA; Qayed M; Mehta A; Khoury HJ; Harvey RD; Suessmuth Y; Couture C; Carr J -
An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig.
Am J Transplant Volume: 13 Page(s): 3021 - 3030
11/01/2013 Authors: Pinelli DF; Wagener ME; Liu D; Yamniuk A; Tamura J; Grant S; Larsen CP; Suri A; Nadler SG; Ford ML -
LONG-TERM BELATACEPT MAINTAINS EFFICACY & SAFETY: 5-YEAR BENEFIT LONG-TERM EXTENSION (LTE) RESULTS
TRANSPLANT INTERNATIONAL Volume: 26 Page(s): 44 - 44
11/01/2013 Authors: Rostaing L; Vincenti F; Grinyo JM; Rice K; Steinberg SM; Gaite L; Moal M-C; Pupim L; Larsen C -
Influence of Antigenicity upon the Instant Blood Mediated Inflammatory Reaction in a Dual Transplant Model of Islet Transplantation
Volume: 96 Page(s): S124 - S124
09/27/2013 Authors: Martin B; Lowe M; Thompson P; Anderson D; Leopardi F; Cano J; Song M; Strobert E; Farris A; Larsen C -
Necrosis and immune activation: does tissue death alter acquired alloimmunity?
Volume: 217 Page(s): S141 - S142
09/01/2013 Authors: Hashmi SS; Ford ML; Larsen CP; Kirk AD -
Combined Costimulatory and OX40L Blockade Significantly Prolongs Transplant Survival in Mice and Non-Human Primates
Volume: 13 Page(s): 50 - 50
04/01/2013 Authors: Kitchens W; Wakwe W; Breeden C; Yagita H; Kirk A; Larsen C; Fuentes M; Ford M; Adams A -
Low Affinity Memory CD8(+) T Cells Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity
Volume: 13 Page(s): 143 - 143
04/01/2013 Authors: Krummey S; Larsen C; Ford M -
Cell Necrosis and Immune Activation: Does Injury Alter Acquired Alloimmunity?
Volume: 13 Page(s): 364 - 365
04/01/2013 Authors: Hashmi S; Ford M; Larsen C; Kirk A -
In-Vivo Persistence, Trafficking and Phenotypic Stability of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells
Volume: 13 Page(s): 77 - 77
04/01/2013 Authors: Singh K; Stempora L; Garrett A; Kirk A; Larsen C; Blazar B; Kean L -
Comparison of Baseline and Day 28 Post Transplant Renal Allograft Samples from the CTOT-10 Belatacept Study.
Volume: 13 Page(s): 225 - 225
04/01/2013 Authors: Suessmuth Y; Stempora L; Johnson B; Cheeseman J; Morrison Y; Bridges N; Ikle D; Tomlanovich S; Stock P; Mannon R -
Th17 Memory Cells Are More Dependent on Coinhibition by CTLA-4 Than Th1 Memory Cells and Are Associated with Rejection in Patients Treated with Belatacept.
Volume: 13 Page(s): 252 - 252
04/01/2013 Authors: Krummey S; Cheeseman J; Jang P; Mehta A; Kirk A; Larsen C; Ford M -
Preservation of CMV-Specific Memory T Cell Responses with Belatacept.
Volume: 13 Page(s): 334 - 334
04/01/2013 Authors: Xu H; Mehta A; Cheeseman J; Pearson T; Larsen C; Kirk A -
Defining the Effects of Transgenic Modification in Islet Xenotransplantation Using the Dual Transplant Model.
Volume: 13 Page(s): 371 - 372
04/01/2013 Authors: Martin B; Thompson P; Lowe M; Farris A; Song M; Strobert E; Jenkins J; Larsen C; Kirk A -
The Combination of Steroids and Methotrexate with Costimulation Blockade Prolongs Renal Allograft Survival.
Volume: 13 Page(s): 475 - 475
04/01/2013 Authors: Anderson D; Lo D; Leopardi F; Turgeon N; Strobert E; Jenkins J; Larsen C; Kirk A -
Belatacept Post-Approval Implementation: A Large Single Center Experience.
Volume: 13 Page(s): 545 - 545
04/01/2013 Authors: Adams A; Garrett C; Chami A; Harler M; Pastan S; Kirk A; Pearson T; Larsen C -
A Chimeric Antibody Against LFA-1 Does Not Synergize with Belatacept in Primate Renal Transplantation.
Volume: 13 Page(s): 475 - 475
04/01/2013 Authors: Anderson D; Leopardi F; Turgeon N; Strobert E; Jenkins J; Wang R; Reimann K; Larsen C; Kirk A -
Alemtuzumab Induction and Belatacept-Based Immunosuppression in Renal Transplant Recipients: Peripheral Dynamics of T and B Cell Populations with Potential Regulatory Signatures.
Volume: 13 Page(s): 85 - 86
04/01/2013 Authors: Xu H; Mead S; Stempora L; Pearon T; Larsen C; Kirk A -
Long-Term Belatacept Exposure Maintains Efficacy and Safety at 5 Years: Results from the Long-Term Extension (LTE) of the Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial (BENEFIT) Study
Volume: 13 Page(s): 312 - 312
04/01/2013 Authors: Larsen C; Vincenti F; Grinyo J; Rice K; Steinberg S; Gaite L; Moal M; Pupim L; Rostaing L -
Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation
Volume: 13 Page(s): 177 - 177
04/01/2013 Authors: Kwun J; Page E; Gibby A; Hong J; Farris A; Adams A; Iwakoshi N; Larsen C; Kirk A; Knechtle S -
Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
Am J Transplant Volume: 13 Page(s): 312 - 319
02/01/2013 Authors: Lowe MC; Badell IR; Turner AP; Thompson PW; Leopardi FV; Strobert EA; Larsen CP; Kirk AD -
Phospholipase A2 Receptor Staining (PLA2R) Is Very Rare in De Novo Membranous Glomerulopathy in the Renal Transplant
Volume: 26 Page(s): 389A - 389A
02/01/2013 Authors: Larsen CP; Walker PD -
Phospholipase A2 Receptor Staining (PLA2R) Is Very Rare in De Novo Membranous Glomerulopathy in the Renal Transplant
Volume: 93 Page(s): 389A - 389A
02/01/2013 Authors: Larsen CP; Walker PD -
Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.
Am J Transplant Volume: 13 Page(s): 320 - 328
02/01/2013 Authors: Lo DJ; Anderson DJ; Weaver TA; Leopardi F; Song M; Farris AB; Strobert EA; Jenkins J; Turgeon NA; Mehta AK -
Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.
PLoS One Volume: 8 Page(s): e71221
01/01/2013 Authors: Beus JM; Hashmi SS; Selvaraj SA; Duan D; Stempora LL; Monday SA; Cheeseman JA; Hamby KM; Speck SH; Larsen CP -
Long-Term Extension of the Belatacept BENEFIT Study: Results at Month 48
TRANSPLANTATION Volume: 94 Page(s): 101 - 101
11/27/2012 Authors: Vincenti F; Charpentier B; Rostaing L; Reyes-Acevedo R; Massari P; Vitko S; Alberu J; Harler MB; Duan T; Larsen C -
Long-Term Extension of the Belatacept BENEFIT Study: Results at Month 48
TRANSPLANTATION Volume: 94 Page(s): 958 - 958
11/27/2012 Authors: Vincenti F; Charpentier B; Rostaing L; Reyes-Acevedo R; Massari P; Vitko S; Alberu J; Harler MB; Duan T; Larsen C -
Bone Marrow Cavity Is a Feasible Site for Islet Transplantation in Nonhuman Primates
TRANSPLANTATION Volume: 94 Page(s): 161 - 161
11/27/2012 Authors: Lowe M; Martin B; Leopardi F; Song M; Strobert E; Kirk AD; Kean L; Larsen CP -
A novel monoclonal antibody to CD40 prolongs islet allograft survival.
Am J Transplant Volume: 12 Page(s): 2079 - 2087
08/01/2012 Authors: Lowe M; Badell IR; Thompson P; Martin B; Leopardi F; Strobert E; Price AA; Abdulkerim HS; Wang R; Iwakoshi NN -
Improvement in outcomes of clinical islet transplantation: 1999-2010.
Diabetes Care Volume: 35 Page(s): 1436 - 1445
07/01/2012 Authors: Barton FB; Rickels MR; Alejandro R; Hering BJ; Wease S; Naziruddin B; Oberholzer J; Odorico JS; Garfinkel MR; Levy M -
Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.
Am J Transplant Volume: 12 Page(s): 1755 - 1764
07/01/2012 Authors: Ramakrishnan SK; Page A; Farris AB; Singh K; Leopardi F; Hamby K; Sen S; Polnett A; Deane T; Song M -
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
Am J Transplant Volume: 12 Page(s): 1765 - 1775
07/01/2012 Authors: Thompson P; Badell IR; Lowe M; Turner A; Cano J; Avila J; Azimzadeh A; Cheng X; Pierson RN; Johnson B -
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
Am J Transplant Volume: 12 Page(s): 1918 - 1923
07/01/2012 Authors: Badell IR; Russell MC; Cardona K; Shaffer VO; Turner AP; Avila JG; Cano JA; Leopardi FV; Song M; Strobert EA -
Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
Am J Transplant Volume: 12 Page(s): 1441 - 1457
06/01/2012 Authors: Singh K; Kozyr N; Stempora L; Kirk AD; Larsen CP; Blazar BR; Kean LS -
The Antibody Response to EBV Is Associated with the Risk of Acute Rejection in Renal Transplant Recipients
Volume: 12 Page(s): 472 - 472
05/01/2012 Authors: Beus JM; Mehta AK; Eady R; Larsen CP; Kirk AD -
4-Year Results from the Long-Term Extension of the Belatacept BENEFIT Study
Volume: 12 Page(s): 82 - 82
05/01/2012 Authors: Larsen C; Alberu J; Massari P; Reyes Acevedo R; Kamar N; Lin C-S; Harler MB; Vincenti F -
Anti-IL12/23 Synergizes with Costimulatory Blockade To Suppress Intragraft IL-17 and Prolong Transplant Survival in Mice and Non-Human Primates
Volume: 12 Page(s): 161 - 162
05/01/2012 Authors: Kitchens WH; Kirk AD; Larsen CP; Ford ML; Adams AB -
Comparison of Viral Immunity in Stable Renal Allograft Recipients Treated with Belatacept or Tacrolimus
Volume: 12 Page(s): 40 - 40
05/01/2012 Authors: Suessmuth Y; Thompson PW; Breeden C; Xu H; Johnson BE; Jones RL; Stempora LA; Cheeseman J; Joseph J; Begley B -
Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
Volume: 12 Page(s): 197 - 197
05/01/2012 Authors: Kirk AD; Mehta AK; Guasch A; Mead S; Xu H; Cheeseman J; Horan J; Kean L; Larsen CP; Pearson TC -
Belatacept/Rapamycin Maintenance Immunosuppression Preserves CMV-Specific Memory Cell Responses after Renal Transplantation
Volume: 12 Page(s): 41 - 42
05/01/2012 Authors: Xu H; Mehta AK; Cheeseman JA; Stempora L; Pearson TC; Larsen CP; Kirk AD -
Rhesus Macaque Tregs Exhibit Decreased Proliferation but Enhanced Suppression after Pulsing with Sirolimus, and Effectively Combine with Belatacept To Inhibit Alloreactivity.
Volume: 12 Page(s): 138 - 138
05/01/2012 Authors: Singh K; Kozyr N; Stempora L; Hamby K; Garrett A; Leopardi F; Kim E; Adams A; Turgeon N; Kirk AD -
A Novel Non-Depleting Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 12 Page(s): 35 - 35
05/01/2012 Authors: Lowe MC; Badell IR; Thompson P; Martin B; Strobert E; Price AA; Abdulkerim HS; Wang R; Iwakoshi NN; Adams AB -
A Prospective Comparative Study of Immune Responses to Influenza Vaccination in Transplant Recipients and Healthy Volunteers
Volume: 12 Page(s): 281 - 281
05/01/2012 Authors: Wrammert J; Mehta AK; McCausland M; Kokko K; Ahmed R; Larsen CP -
Belatacept and Sirolimus Promote Renal Allograft Survival in a Calcineurin Inhibitor-Free, Steroid-Sparing Regimen in Nonhuman Primates
Volume: 12 Page(s): 35 - 35
05/01/2012 Authors: Lo DJ; Anderson DJ; Weaver T; Leopardi F; Song M; Farris AB; Strobert E; Jenkins J; Turgeon NA; Mehta AK -
Inhibition of alpha v beta 6-Mediated TGF-beta Activation Promotes Acute Rejection of Renal Allografts in Nonhuman Primates
Volume: 12 Page(s): 67 - 67
05/01/2012 Authors: Lo DJ; Farris AB; Song M; Leopardi F; Strobert E; Jenkins J; Turgeon NA; Mehta AK; Maroni B; Violette S -
CD40 Expressed by Donor-Reactive CD8+T Cells Prevents Foxp3+iTreg Conversion Following Transplantation.
Volume: 12 Page(s): 137 - 137
05/01/2012 Authors: Liu D; Ferrer IR; Larsen CP; Ford ML -
Belatacept and Sirolimus Prolong Islet Allograft Survival in Nonhuman Primates
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 12 Page(s): 479 - 479
05/01/2012 Authors: Lowe MC; Badell IR; Turner A; Thompson P; Martin B; Leopardi F; Strobert E; Larsen CP; Kirk AD -
The impact of renal function on outcomes of bariatric surgery.
J Am Soc Nephrol Volume: 23 Page(s): 885 - 894
05/01/2012 Authors: Turgeon NA; Perez S; Mondestin M; Davis SS; Lin E; Tata S; Kirk AD; Larsen CP; Pearson TC; Sweeney JF -
Methotrexate Prolongs Renal Allograft Survival beyond Costimulation Blockade Alone
Volume: 12 Page(s): 35 - 35
05/01/2012 Authors: Anderson DJ; Lo DJ; Leopardi F; Turgeon N; Strobert E; Jenkins JB; Larsen CP; Kirk AD -
Novel Dual Transplant Model: In Vivo Evaluation of Gal-Deficient and Wild-Type Xenoislet Preparations within a Single Recipient
Volume: 12 Page(s): 478 - 478
05/01/2012 Authors: Martin B; Thompson P; Lowe M; Farris AB; Song M; Strobert E; Larsen CP; Kirk AD -
Overcoming Latent Virus-Mediated Heterologous Immunity: The Infection-Associated Accumulation of KLRG1+ CD8+ Effector/Effector Memory T Cells Is Reversed with Combined Costimulation and Adhesion Blockade
Volume: 12 Page(s): 39 - 39
05/01/2012 Authors: Hashmi S; Beus J; Duan D; Speck S; Larsen CP; Kirk AD; Kean LS -
Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.
Am J Transplant Volume: 12 Page(s): 812 - 819
04/01/2012 Authors: Kean LS; Singh K; Blazar BR; Larsen CP -
Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.
Immunogenetics Volume: 64 Page(s): 329 - 336
04/01/2012 Authors: Johnson ZP; Eady RD; Ahmad SF; Agravat S; Morris T; Else J; Lank SM; Wiseman RW; O'Connor DH; Penedo MCT -
Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant.
Am J Transplant Volume: 12 Page(s): 438 - 446
02/01/2012 Authors: Neujahr DC; Perez SD; Mohammed A; Ulukpo O; Lawrence EC; Fernandez F; Pickens A; Force SD; Song M; Larsen CP -
RHESUS MACAQUE NATURAL CD4 REGULATORY T CELLS EXHIBIT DECREASED PROLIFERATION BUT ENHANCED SUPPRESSION AFTER PULSING WITH SIROLIMUS
Volume: 18 Page(s): S201 - S201
02/01/2012 Authors: Singh K; Stempora L; Kirk AD; Larsen CP; Blazar BB; Kean LS -
Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.
Am J Transplant Volume: 12 Page(s): 69 - 80
01/01/2012 Authors: Kitchens WH; Haridas D; Wagener ME; Song M; Kirk AD; Larsen CP; Ford ML -
CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
Am J Transplant Volume: 12 Page(s): 115 - 125
01/01/2012 Authors: Page A; Srinivasan S; Singh K; Russell M; Hamby K; Deane T; Sen S; Stempora L; Leopardi F; Price AA -
Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.
Am J Transplant Volume: 12 Page(s): 210 - 217
01/01/2012 Authors: Vincenti F; Larsen CP; Alberu J; Bresnahan B; Garcia VD; Kothari J; Lang P; Urrea EM; Massari P; Mondragon-Ramirez G -
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
Am J Transplant Volume: 12 Page(s): 126 - 135
01/01/2012 Authors: Badell IR; Thompson PW; Turner AP; Russell MC; Avila JG; Cano JA; Robertson JM; Leopardi FV; Strobert EA; Iwakoshi NN -
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
Proc Natl Acad Sci U S A Volume: 108 Page(s): 20701 - 20706
12/20/2011 Authors: Ferrer IR; Wagener ME; Song M; Kirk AD; Larsen CP; Ford ML -
Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.
Transplant Proc Volume: 43 Page(s): 3892 - 3898
12/01/2011 Authors: Mohammed A; Ulukpo O; Lawrence EC; Fernandez F; Pickens A; Gal AA; Force SD; Easley KC; Larsen CP; Kirk AD -
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
Am J Transplant Volume: 11 Page(s): 2593 - 2602
12/01/2011 Authors: Thompson P; Badell IR; Lowe M; Cano J; Song M; Leopardi F; Avila J; Ruhil R; Strobert E; Korbutt G -
LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
Blood Volume: 118 Page(s): 5851 - 5861
11/24/2011 Authors: Reisman NM; Floyd TL; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells
Volume: 118 Page(s): 461 - 461
11/18/2011 Authors: Singh K; Kozyr N; Stempora L; Kirk AD; Larsen CP; Blazar BR; Kean LS -
Glial cell line-derived neurotrophic factor enhances human islet posttransplantation survival.
Transplantation Volume: 92 Page(s): 745 - 751
10/15/2011 Authors: Mwangi SM; Usta Y; Shahnavaz N; Joseph I; Avila J; Cano J; Chetty VK; Larsen CP; Sitaraman SV; Srinivasan S -
THREE-YEAR OUTCOMES FROM BENEFIT: A PHASE III STUDY OF BELATACEPT VS CYCLOSPORINE IN KIDNEY TRANSPLANT RECIPIENTS
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 21 - 21
10/01/2011 Authors: Vincenti F; Larsen C; Alberu J; Garcia V; Rostaing L; Rice K; Schnitzler M; Xing J; Agarwal M; Charpentier B -
3-YEAR SAFETY PROFILE OF BELATACEPT IN KIDNEY TRANSPLANT RECIPIENTS FROM THE BENEFIT AND BENEFIT-EXT STUDIES
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 51 - 51
10/01/2011 Authors: Larsen C; Grinyo J; Medina Pestana J; Vanrenterghem Y; Vincenti F; Dong Y; Thomas D; Charpentier B -
THREE YEAR OUTCOMES BY DONOR TYPE IN PHASE III STUDIES OF BELATACEPT VS CYCLOSPORINE IN KIDNEY TRANSPLANTATION (BENEFIT AND BENEFIT-EXT)
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 51 - 51
10/01/2011 Authors: Florman S; Becker T; Bresnahan B; Chevaile-Ramos A; Carvalho D; Muehlbacher F; O'Connell P; Duan T; Agarwal M; Larsen C -
BENEFIT-EXT STUDY TWO YEAR OUTCOMES: BELATACEPT VS CYCLOSPORINE (CSA) IN EXTENDED CRITERIA DONOR (ECD) KIDNEY TRANSPLANTS
Volume: 89 Page(s): A2 - A2
10/01/2011 Authors: Russ G; Durrbach A; Larsen CP; Pestana MJ; Vanrenterghem Y; Vincenti F; Florman S; Xing J; Block A; Garg P -
THREE-YEAR OUTCOMES FROM BENEFIT: A PHASE III STUDY OF BELATACEPT VS CYCLOSPORINE IN KIDNEY TRANSPLANT RECIPIENTS
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 68 - 68
09/01/2011 Authors: Vincenti F; Larsen CP; Alberu J; Garcia VD; Rostaing L; Rice K; Schnitzler M; Xing J; Agarwal M; Charpentier B -
3-YEAR SAFETY PROFILE OF BELATACEPT IN KIDNEY TRANSPLANT RECIPIENTS FROM THE BENEFIT AND BENEFIT-EXT STUDIES
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 68 - 69
09/01/2011 Authors: Charpentier B; Grinyo J; Medina Pestana JO; Vanrenterghem Y; Vincenti F; Dong Y; Thomas D; Larsen CP -
DONOR SUB-TYPE ANALYSIS OF THREE-YEAR OUTCOMES FROM A PHASE III STUDY OF BELATACEPT IN RECIPIENTS OF EXTENDED CRITERIA DONOR KIDNEYS (BENEFIT-EXT TRIAL)
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 221 - 222
09/01/2011 Authors: Muehlbacher F; Becker T; Campistol JM; Carvalho DBM; Florman S; Lang P; Duan T; Agarwal M; Larsen CP -
EVALUATION OF DONOR-SPECIFIC ANTIBODIES IN KIDNEY TRANSPLANT PATIENTS TREATED WITH BELATACEPT- OR CYCLOSPORINE-BASED IMMUNOSUPPRESSION IN BENEFIT AND BENEFIT-EXT
TRANSPLANT INTERNATIONAL Volume: 24 Page(s): 69 - 69
09/01/2011 Authors: Larsen CP; Bray R; Gebel H; Ganguly B; Kulbokas E; Brickman D; Duan T; Townsend R -
Transplantation tolerance: memories that haunt us.
Sci Transl Med Volume: 3 Page(s): 86ps22
06/08/2011 Authors: Ford ML; Larsen CP -
Miles to go.
Am J Transplant Volume: 11 Page(s): 1119 - 1120
06/01/2011 Authors: Kirk AD; Knechtle SJ; Larsen CP; Newell KA; Pearson TC -
Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies).
Transplantation Volume: 91 Page(s): 976 - 983
05/15/2011 Authors: Vanrenterghem Y; Bresnahan B; Campistol J; Durrbach A; Griny J; Neumayer H-H; Lang P; Larsen CP; Mancilla-Urrea E; Pestana JM -
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
Am J Transplant Volume: 11 Page(s): 947 - 957
05/01/2011 Authors: Thompson P; Cardona K; Russell M; Badell IR; Shaffer V; Korbutt G; Rayat GR; Cano J; Song M; Jiang W -
In Vivo Characterization of Novel Non-Depleting Anti-CD40 Monoclonal Antibodies in Nonhuman Primates.
Volume: 11 Page(s): 474 - 474
04/01/2011 Authors: Lowe M; Thompson P; Badel I; Reimann K; Strobert E; Iwakoshi N; Kirk A; Larsen C -
The Chemokines CXCL10 and CXCL11 Are Produced Directly by Renal Proximal Tubular Epithelial Cells in Response to Monocyte Derived TNF-alpha.
Volume: 11 Page(s): 233 - 233
04/01/2011 Authors: Xu H; Kim EJ; Larsen C; Kirk AD -
Chronic Kidney Disease and CMV Drive Patient Specific Pre-Transplant Immune Deviations Toward Terminal Differentiation and Exhaustion.
Volume: 11 Page(s): 388 - 388
04/01/2011 Authors: Mehta AK; McCausland M; Lo DJ; Joseph J; Cheeseman J; Elbein R; Gourley T; Mulupuri P; Miller J; Kirk AD -
Targeting the "Therapeutic Window" in Transplantation Via Differential Expression of LFA-1 on Pathogen vs. Allograft-Specific CD8(+) T Cells.
Volume: 11 Page(s): 474 - 474
04/01/2011 Authors: Haridas D; Wagener ME; Kirk AD; Larsen CP; Ford ML -
CD40/CD154 Pathway Blockade Mediates Conversion of Antigen-Specific CDC+ T Cells into FoxP3(+) Cells and Inhibits CD8(+) T Cell Effector Function.
Volume: 11 Page(s): 342 - 342
04/01/2011 Authors: Ferrer IR; Wagener ME; Song M; Kirk AD; Ford ML; Larsen CP -
Immunologic Ramifications of Depletion Induction Therapy and CMV Viremia in a Renal Transplant Cohort.
Volume: 11 Page(s): 389 - 389
04/01/2011 Authors: Mehta AK; McCausland M; Joseph J; Cheeseman J; Duraiswamy J; Mulupuri P; Gourley T; Miller J; Kokko K; Kirk AD -
3-Year Safety Profile of Belatacept in Kidney Transplant Recipients from the BENEFIT and BENEFIT-EXT Studies
Volume: 11 Page(s): 99 - 100
04/01/2011 Authors: Larsen C; Grinyo J; Pestana JM; Vanrenterghem Y; Vincenti F; Dong Y; Thomas D; Charpentier B -
The Effect of Costimulation Blockade with Belatacept on EBV Specific Immunity.
Volume: 11 Page(s): 346 - 346
04/01/2011 Authors: Mehta AK; Turner PL; Xu H; Stempora LL; Nadler S; Kirk AD; Larsen CP -
Identifying a Signature of Transplant Rejection in Non-Human Primates: Upregulation of CD95 Is a Site-Specific Marker That Strongly Correlates with Transplant Rejection
Volume: 11 Page(s): 391 - 392
04/01/2011 Authors: Srinivasan SK; Page AJ; Singh K; Kirk AD; Larsen CP; Kean LS -
Overcoming Heterologous Immunity: Virus-Mediated, Costimulation Blockade-Resistant Transplant Rejection Is Reversed by Blocking T Cell Adhesion Pathways.
Volume: 11 Page(s): 29 - 29
04/01/2011 Authors: Beus JM; Duan D; Speck SH; Larsen CP; Kirk AD; Kean LS -
Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy.
Volume: 11 Page(s): 45 - 45
04/01/2011 Authors: Kirk AD; Mead S; Xu H; Mehta A; Guasch A; Cheeseman J; Joseph J; Horan J; Kean L; Larsen CP -
Defining Populations of Pathogen-Elicited Donor-Specific Memory T Cells with Different Susceptibility to Costimulatory Blockade.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Kitchens WH; Kirk AD; Larsen CP; Ford ML -
Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall.
Volume: 11 Page(s): 219 - 219
04/01/2011 Authors: Ford ML; Floyd TL; Koehn BH; Kitchens WH; Robertson JM; Cheeseman JA; Stempora LL; Larsen CP -
Islet Xenotransplantation Using Gal-Deficient Neonatal Porcine Donors Improves Engraftment and Function
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 11 Page(s): 80 - 80
04/01/2011 Authors: Thompson P; Badell I; Lowe M; Cano J; Song M; Ruhil R; Strobert E; Iwakoshi N; Larsen C; Kirk A -
Belatacept, but Not Calcineurin Inhibitors, Preserve Human CMV-Specific Memory Cell Responses.
Volume: 11 Page(s): 44 - 44
04/01/2011 Authors: Xu H; Mehta AK; Mead S; Cheeseman J; Stempora L; Pearson TC; Larsen C; Kirk AD -
Alefacept Improves Efficacy of Costimulation Blockade in Nonhuman Primate Islet Allograft Survival
Volume: 11 Page(s): 116 - 116
04/01/2011 Authors: Lowe M; Badel I; Turner A; Thompson P; Weaver T; Leopardi F; Strobert E; Larsen C; Kirk A -
Clinically Applicable Immunosuppression with LFA3-Ig and Anti-LFA-1 Prolongs Xenoislet Survival
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 11 Page(s): 107 - 107
04/01/2011 Authors: Thompson P; Badell I; Lowe M; Azimzadeh A; Cano J; Strobert E; Song M; Rajotte R; Larsen C; Kirk A -
Adjuvant Treatment with Alefacept (LFA-3-Ig) Promotes Belatacept-Based Immunomodulation in Renal Transplantation in Nonhuman Primates.
Volume: 11 Page(s): 172 - 173
04/01/2011 Authors: Lo DJ; Weaver T; Leopardi F; Song M; Farris AB; Turgeon NA; Mehta AK; Larsen CP; Kirk AD -
Cumulative Exposure to Gamma Interferon Dependent Chemokines CXCL9 and CXCL10 Is Associated with Worse Function after Lung Transplantation.
Volume: 11 Page(s): 35 - 35
04/01/2011 Authors: Neujahr DC; Mohammed A; Ulukpo O; Lawrence EC; Fernandez F; Pickens A; Force SD; Larsen CP; Kirk AD -
Three-Year Outcomes from BENEFIT: A Phase III Study of Belatacept vs Cyclosporine in Kidney Transplant Recipients
Volume: 11 Page(s): 99 - 99
04/01/2011 Authors: Vincenti F; Larsen CP; Alberu J; Garcia VD; Rostaing L; Rice K; Schnitzler M; Xing J; Agarwal M; Charpentier B -
Three-Year Outcomes by Donor Type in Phase III Studies of Belatacept vs Cyclosporine in Kidney Transplantation (BENEFIT & BENEFIT-EXT)
Volume: 11 Page(s): 100 - 100
04/01/2011 Authors: Florman S; Becker T; Bresnahan B; Chevaile-Ramos A; DeCarvalho D; Muehlbacher F; O'Connell P; Duan T; Agarwal M; Larsen C -
Cumulative Exposure to CD8 T Cells with Granzyme B Is Associated with Worse Lung Function Early after Lung Transplantation
Volume: 11 Page(s): 395 - 395
04/01/2011 Authors: Neujahr DC; Mohammed A; Ulukpo O; Fernandez F; Pickens A; Lawrence EC; Easley KC; Force SD; Kirk AD; Larsen CP -
LFA-1 Blockade Induces Effector and Regulatory T Cell Enrichment in Lymph Nodes and Increases Effector T Cell Death.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Ford ML; Reisman NM; Floyd TL; Wagener ME; Kirk AD; Larsen CP -
Rapamycin Augments CD8(+) T Cell Responses to Latent and Chronic Viral Infections but Not Heterologous Immune Graft-Reactive Responses.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Ferrer IR; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8(+) Memory T Cells
Volume: 11 Page(s): 477 - 477
04/01/2011 Authors: Kitchens WH; Haridas D; Kirk AD; Larsen CP; Ford ML -
T-Cell Chimerism and Tolerance: Proof-In-Principle from a Novel Rhesus Macaque Model.
Volume: 11 Page(s): 441 - 441
04/01/2011 Authors: Srinivasan SK; Hamby K; Sen S; Deane T; Singh K; Stempora L; Larsen CP; Kean LS -
Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
J Immunol Volume: 186 Page(s): 2693 - 2697
03/01/2011 Authors: Larsen CP; Elwood ET; Alexander DZ; Ritchie SC; Hendrix R; Tucker-Burden C; Cho HR; Aruffo A; Hollenbaugh D; Linsley PS -
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.
Am J Transplant Volume: 11 Page(s): 613 - 618
03/01/2011 Authors: Turner AP; Shaffer VO; Araki K; Martens C; Turner PL; Gangappa S; Ford ML; Ahmed R; Kirk AD; Larsen CP -
Integrin antagonists for transplant immunosuppression: panacea or peril?
Immunotherapy Volume: 3 Page(s): 305 - 307
03/01/2011 Authors: Kitchens WH; Larsen CP; Ford ML -
Regulatory T cells in lung transplantation--an emerging concept.
Semin Immunopathol Volume: 33 Page(s): 117 - 127
03/01/2011 Authors: Neujahr DC; Larsen CP -
Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.
J Immunol Volume: 186 Page(s): 2033 - 2041
02/15/2011 Authors: Floyd TL; Koehn BH; Kitchens WH; Robertson JM; Cheeseman JA; Stempora L; Larsen CP; Ford ML -
CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha.
Transpl Immunol Volume: 24 Page(s): 94 - 99
01/15/2011 Authors: Ford ML; Stempora LL; Larsen CP -
Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
Am J Transplant Volume: 11 Page(s): 22 - 33
01/01/2011 Authors: Lo DJ; Weaver TA; Stempora L; Mehta AK; Ford ML; Larsen CP; Kirk AD -
Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies.
Transplantation Volume: 90 Page(s): 1528 - 1535
12/27/2010 Authors: Larsen CP; Griny J; Medina-Pestana J; Vanrenterghem Y; Vincenti F; Breshahan B; Campistol JM; Florman S; Rial MDC; Kamar N -
An integrated safety profile analysis of belatacept in kidney transplant recipients.
Transplantation Volume: 90 Page(s): 1521 - 1527
12/27/2010 Authors: Griny J; Charpentier B; Pestana JM; Vanrenterghem Y; Vincenti F; Reyes-Acevedo R; Apanovitch AM; Gujrathi S; Agarwal M; Thomas D -
GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression.
Blood Volume: 116 Page(s): 5403 - 5418
12/09/2010 Authors: Miller WP; Srinivasan S; Panoskaltsis-Mortari A; Singh K; Sen S; Hamby K; Deane T; Stempora L; Beus J; Turner A -
LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
J Clin Invest Volume: 120 Page(s): 4520 - 4531
12/01/2010 Authors: Badell IR; Russell MC; Thompson PW; Turner AP; Weaver TA; Robertson JM; Avila JG; Cano JA; Johnson BE; Song M -
Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue.
Volume: 116 Page(s): 625 - 625
11/19/2010 Authors: Beus J; Hamby K; Kirk AD; Larsen CP; Speck SH; Kean L -
An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
Am J Transplant Volume: 10 Page(s): 2396 - 2409
11/01/2010 Authors: Larsen CP; Page A; Linzie KH; Russell M; Deane T; Stempora L; Strobert E; Penedo MCT; Ward T; Wiseman R -
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.
J Exp Med Volume: 207 Page(s): 2355 - 2367
10/25/2010 Authors: Araki K; Gangappa S; Dillehay DL; Rouse BT; Larsen CP; Ahmed R -
BELATACEPT VS CYCLOSPORINE IN KIDNEY TRANSPLANT RECIPIENTS: TWO-YEAR OUTCOMES FROM THE BENEFIT STUDY
TRANSPLANT INTERNATIONAL Volume: 23 Page(s): 59 - 59
10/01/2010 Authors: Larsen C; Grinyo J; Charpentier B; Medina Pestana J; Kamar N; Vanrenterghem Y; Lin C; Di Russo G; Garg P; Vincenti F -
SAFETY PROFILE OF BELATACEPT IN KIDNEY TRANSPLANT RECIPIENTS FROM A POOLED ANALYSIS OF PHASE II AND PHASE III STUDIES
TRANSPLANT INTERNATIONAL Volume: 23 Page(s): 59 - 60
10/01/2010 Authors: Grinyo J; Charpentier B; Medina Pestana J; Vanrenterghem Y; Vincenti F; Shi R; Agarwal M; Thomas D; Larsen C -
BELATACEPT VS CYCLOSPORINE IN ECD KIDNEY TRANSPLANTS: TWO-YEAR OUTCOMES FROM THE BENEFIT-EXT STUDY
TRANSPLANT INTERNATIONAL Volume: 23 Page(s): 59 - 59
10/01/2010 Authors: Durrbach A; Larsen C; Medina Pestana J; Vanrenterghem Y; Vincenti F; Florman S; Xing J; Block A; Garg P; Grinyo J -
Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series.
Chest Volume: 138 Page(s): 937 - 943
10/01/2010 Authors: Neujahr DC; Mohammed A; Ulukpo O; Force SD; Ramirez AM; Pelaez A; Lawrence EC; Larsen CP; Kirk AD -
Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
Am J Transplant Volume: 10 Page(s): 2082 - 2091
09/01/2010 Authors: Turgeon NA; Avila JG; Cano JA; Hutchinson JJ; Badell IR; Page AJ; Adams AB; Sears MH; Bowen PH; Kirk AD -
Five-year safety and efficacy of belatacept in renal transplantation.
J Am Soc Nephrol Volume: 21 Page(s): 1587 - 1596
09/01/2010 Authors: Vincenti F; Blancho G; Durrbach A; Friend P; Grinyo J; Halloran PF; Klempnauer J; Lang P; Larsen CP; Mhlbacher F -
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
J Immunol Volume: 185 Page(s): 2004 - 2008
08/15/2010 Authors: Ferrer IR; Wagener ME; Robertson JM; Turner AP; Araki K; Ahmed R; Kirk AD; Larsen CP; Ford ML -
Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations.
Curr Opin Organ Transplant Volume: 15 Page(s): 405 - 410
08/01/2010 Authors: Ford ML; Larsen CP -
High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
Transplantation Volume: 89 Page(s): 1208 - 1217
05/27/2010 Authors: Floyd TL; Orr SB; Coley SM; Hanna SS; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Glial Cell Line Derived Neurotrophic Factor Enhances Human Islet Pre- And Post-Transplantation Survival
Volume: 138 Page(s): S611 - S611
05/01/2010 Authors: Shahnavaz N; Mwangi SM; Usta Y; Joseph I; Avila J; Cano J; Chetty VK; Larsen CP; Srinivasan S -
Beyond Trafficking: Blockade of LFA-1/ICAM Critically Impacts CD8+T Cell Acquisition of Donor-Specific Cytokine Production and Cytolytic Activity
Volume: 10 Page(s): 463 - 463
04/01/2010 Authors: Reisman NM; Wagener M; Ferrer IR; Kirk AD; Larsen CP; Ford ML -
Donor-Reactive CD8+T Cells Induce Sustained DC Activation and Enhance Graft-Specific Th1 Polarization.
Volume: 10 Page(s): 202 - 203
04/01/2010 Authors: Ford ML; Liu D; Stempora L; Larsen CP -
Split Tolerance in Primates: Rapid Rejection of Renal Allografts Despite High Level, Persistent Myeloid Chimerism.
Volume: 10 Page(s): 564 - 564
04/01/2010 Authors: Page A; Srinivasan S; Linzie K; Kirk A; Larsen C; Kean L -
Elevated Bronchoalveolar Lavage Fluid (BAL) CXCL9 and CXCL10 Levels Correlate with ACR in Human Lung Transplants.
Volume: 10 Page(s): 145 - 145
04/01/2010 Authors: Mohammed A; Ulukpo O; Jackson JA; Pelaez A; Ramirez AM; Gal AA; Lawrence EC; Force SD; Larsen CP; Kirk AD -
Towards a Translatable Regimen for Islet Xenotransplantation in Nonhuman Primates
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 10 Page(s): 187 - 187
04/01/2010 Authors: Thompson PW; Badell IR; Turner AP; Avila J; Cano J; Strobert EA; Leopardi FV; Song M; Korbutt GS; Rayat GR -
Rapamycin Augments Pathogen-Specific but Not Donor-Reactive CD8(+) T Cell Responses
Volume: 10 Page(s): 159 - 159
04/01/2010 Authors: Ferrer IR; Wagener ME; Robertson JM; Turner AP; Kirk AD; Larsen CP; Ford ML -
CD40/CD154 Pathway Blockade Critically Alters Dendritic Cell Phenotype and Function To Impair Graft Rejection
Volume: 10 Page(s): 361 - 361
04/01/2010 Authors: Ford ML; Liu D; Stempora L; Hanna SS; Larsen CP -
Dissecting the Post-Transplant Alloresponse: A Primate Model of GvHD Reveals Breakthrough Effector CD8+T Cell Activation and GI-Specific Tolerance-Resistance Despite Costimulation Blockade
Volume: 10 Page(s): 464 - 464
04/01/2010 Authors: Kean L; Miller W; Page A; Srinivasan S; Singh K; Mortari A; Blazar B; Larsen C -
'Lymphoid Urban Planning': Effects of Blockade of the LFA:ICAM Interaction in Lymphocyte Trafficking
Volume: 10 Page(s): 365 - 365
04/01/2010 Authors: Reisman NM; Wagener M; Kirk AD; Larsen CP; Ford ML -
CD40/CD154 Pathway Blockade Prolongs Graft Survival While Inhibiting CD8(+) T Cell Activation and Differentiation
Volume: 10 Page(s): 361 - 361
04/01/2010 Authors: Ferrer IR; Wagener ME; Kirk AD; Ford ML; Larsen CP -
Prolonged Engraftment but Breakthrough Rejection during Primate Mixed Chimerism Induction: T Cell Alloreactivity Remains a Barrier to Tolerance Despite Full MHC Matching.
Volume: 10 Page(s): 146 - 146
04/01/2010 Authors: Page A; Kirk A; Larsen C; Kean L -
Anti-LFA-1 Synergizes with CD28/CD154 Blockade To Inhibit Anti-Donor Cytotoxicity and Promote Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells
Volume: 10 Page(s): 41 - 41
04/01/2010 Authors: Ford ML; Kitchens WH; Robertson JM; Kirk AD; Larsen CP -
In Vivo Characterization of a Novel Recombinant Anti-CD40 Monoclonal Antibody in Nonhuman Primates
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 10 Page(s): 214 - 214
04/01/2010 Authors: Badell IR; Mendel JB; Robertson JM; Johnson BE; Wang X; Wang R; Iwakoshi NN; Reimann KA; Kirk AD; Larsen CP -
Heterologous Immunity and Tolerance-Resistance: The Mouse MHV68 Model of EBV Suggests a Stochastic Effect of CD8 Expansion on the Induction of Alloimmunity
Volume: 10 Page(s): 557 - 557
04/01/2010 Authors: Beus J; Selvaraj S; Hamby K; Kirk A; Larsen C; Kean L -
Surmounting the Memory Barrier: Anti-VLA-4 Improves Transplant Survival with Costimulatory Blockade in a Murine Model of Donor-Specific Memory Response
Volume: 10 Page(s): 557 - 557
04/01/2010 Authors: Kitchens WH; Wagener ME; Larsen CP; Ford ML -
Belatacept vs Cyclosporine in ECD Kidney Transplants: Two-Year Outcomes from the BENEFIT-EXT Study
Volume: 10 Page(s): 83 - 83
04/01/2010 Authors: Durrbach A; Larsen CP; Pestana JM; Vanrenterghem Y; Vincenti F; Florman S; Xing J; Block A; Garg P; Grinyo J -
Belatacept vs Cyclosporine in Kidney Transplant Recipients: Two-Year Outcomes from the BENEFIT Study
Volume: 10 Page(s): 82 - 82
04/01/2010 Authors: Larsen CP; Grinyo J; Charpentier B; Pestana JM; Kamar N; Vanrenterghem Y; Lin C-S; Di Russo G; Garg P; Vincenti F -
Outcomes as a Function of Donor Criteria from a Phase III Study of Belatacept vs Cyclosporine in Kidney Transplantation (BENEFIT-EXT).
Volume: 10 Page(s): 150 - 150
04/01/2010 Authors: Florman S; Durrbach A; Larsen C; Pestana JM; Vanrenterghem Y; Vincenti F; Block A; Garg P; Copley JB; Xing J -
A Novel Non-Depleting Anti-CD40 Antibody Prolongs Allogeneic Islet Survival in Nonhuman Primates.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 10 Page(s): 146 - 146
04/01/2010 Authors: Badell IR; Thompson PW; Turner AP; Avila JG; Cano JA; Robertson JM; Leopardi FV; Johnson BE; Strobert EA; Kirk AD -
Safety Profile of Belatacept in Kidney Transplant Recipients from a Pooled Analysis of Phase II and Phase III Studies
Volume: 10 Page(s): 83 - 83
04/01/2010 Authors: Grinyo J; Charpentier B; Pestana JM; Vanrenterghem Y; Vincenti F; Shi R; Agarwal M; Thomas D; Larsen CP -
Combination CD28/LFA-1 Blockade Promotes Islet Allograft Survival in Nonhuman Primates.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 10 Page(s): 91 - 91
04/01/2010 Authors: Badell IR; Thompson PW; Turner AP; Avila JG; Cano JA; Robertson JM; Leopardi FV; Johnson BE; Strobert EA; Kirk AD -
Signatures of Cytomegalovirus Protective Immunity in the Setting of Immunosuppression
Volume: 10 Page(s): 480 - 480
04/01/2010 Authors: Mehta AK; McClausland M; Mulupuri P; Cheeseman J; Martens C; Ahmed R; Larsen CP -
Experience with a Novel Immunosuppressive Regimen To Facilitate Single Donor Islet Cell Transplantation Using Efalizumab
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 10 Page(s): 122 - 122
04/01/2010 Authors: Turgeon NA; Cano JA; Hutchinson JJ; Badell IR; Page AJ; Kirk AD; Pearson TC; Larsen CP -
Combined Bronchoalveolar Lavage (BAL) Chemokine Scores Correlate with Spirometry in a Longitudinal Analysis of Lung Transplantation.
Volume: 10 Page(s): 487 - 487
04/01/2010 Authors: Mohammed A; Ulukpo OK; Pelaez AA; Ramirez AM; Lawrence EC; Force SD; Easley KC; Larsen CP; Kirk AD; Neujahr DC -
Selective Targeting of Human Alloresponsive CD8(+) Effector Memory T Cells Based on CD2 Expression.
Volume: 10 Page(s): 558 - 558
04/01/2010 Authors: Lo DJ; Weaver TA; Stempora L; Mehta AK; Ford ML; Larsen CP; Kirk AD -
Defining Populations of Donor-Specific Memory T Cells with Different Susceptibility to Costimulatory Blockade
Volume: 10 Page(s): 557 - 557
04/01/2010 Authors: Kitchens WH; Wagener M; Larsen CP; Ford ML -
Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
J Immunol Volume: 184 Page(s): 2410 - 2422
03/01/2010 Authors: Radziewicz H; Ibegbu CC; Hon H; Bdard N; Bruneau J; Workowski KA; Knechtle SJ; Kirk AD; Larsen CP; Shoukry NH -
A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).
Am J Transplant Volume: 10 Page(s): 535 - 546
03/01/2010 Authors: Vincenti F; Charpentier B; Vanrenterghem Y; Rostaing L; Bresnahan B; Darji P; Massari P; Mondragon-Ramirez GA; Agarwal M; Di Russo G -
Flow Cytometric Parameters of CD8 Lavage Cells in Detection of Acute Cellular Rejection in Lung Transplant
Volume: 29 Page(s): S55 - S55
02/01/2010 Authors: Neujahr DC; Mohammed A; Ulukpo O; Pelaez A; Ramirez A; Lawrence EC; Force SD; Gal AA; Larsen CP; Kirk AD -
Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols.
J Magn Reson Imaging Volume: 31 Page(s): 440 - 446
02/01/2010 Authors: Martin DR; Krishnamoorthy SK; Kalb B; Salman KN; Sharma P; Carew JD; Martin PA; Chapman AB; Ray GL; Larsen CP -
What Is Optimal Induction Therapy for Expanded Criteria Donor Kidneys?
Volume: 10 Page(s): 31 - 31
01/01/2010 Authors: Tso PL; Turgeon NA; Newell KA; Pearson TC; Larsen CP; Kirk AD -
Primary Outcomes from a Randomized, Phase III Study of Belatacept Versus Cyclosporine in ECD Kidney Transplants (BENEFIT-EXT Study)
Volume: 10 Page(s): 7 - 7
01/01/2010 Authors: Durrbach A; Florman S; Larsen C; Pestana JM; Vanrenterghem Y; Vincente F; Block A; Garg P; Grinyo J -
Signatures of Cytomegalovirus Protective Immunity in the Setting of Immunosuppression
Volume: 10 Page(s): 36 - 36
01/01/2010 Authors: Mehta AK; McCausland M; Mulupuri P; Cheeseman J; Martens C; Ahmed R; Larsen CP -
Anti-LFA-1 Synergizes with CD28/CD154 Blockade To Inhibit Anti-Donor Cytotoxicity and Promote Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells
Volume: 10 Page(s): 9 - 9
01/01/2010 Authors: Ford ML; Steeds CM; Wagener ME; Robertson JM; Hanna SS; Kirk AD; Larsen CP -
Renal Benefit of Belatacept Versus Cyclosporine in Kidney Transplant Patients Is Not Impacted by Acute Rejection (BENEFIT Study)
Volume: 10 Page(s): 14 - 14
01/01/2010 Authors: Bresnahan B; Vincenti F; Grinyo J; Charpentier B; Di Russo G; Garg P; Larsen C -
Prevention of Acute GvHD During MHC Haploidentical BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model.
Volume: 114 Page(s): 968 - 969
11/20/2009 Authors: Miller W; Wheeler CE; Panoskaltsis-Mortari A; Kirk AD; Larsen CP; Blazar BR; Kean LS -
Successful outcome after early combined liver and en bloc-kidney transplant in an infant with primary hyperoxaluria type 1: a case report.
Pediatr Transplant Volume: 13 Page(s): 940 - 942
11/01/2009 Authors: Heffron TG; Rodriguez J; Fasola CG; Casper K; Pillen T; Smallwood G; Warshaw B; Romero R; Larsen C -
A novel calcineurin inhibitor- and sirolimus-free anti-LFA-1-based therapy enhances allogeneic islet survival and function in nonhuman primates
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS Volume: 209 Page(s): S56 - S56
09/01/2009 Authors: Badell IR; Turner AP; Cano JA; Avila JG; Johnson BE; Leopardi FV; Swygert SG; Strobert EA; Kirk AD; Larsen CP -
A novel calcineurin inhibitor- and sirolimus-free anti-LFA-1-based therapy enhances allogeneic islet survival and function in nonhuman primates
XENOTRANSPLANTATION Volume: 16 Page(s): 314 - 314
09/01/2009 Authors: Badell I; Turner A; Avila J; Cano J; Johnson B; Leopardi F; Swygert S; Strobert E; Kirk A; Larsen C -
Dynamics of human regulatory T cells in lung lavages of lung transplant recipients.
Transplantation Volume: 88 Page(s): 521 - 527
08/27/2009 Authors: Neujahr DC; Cardona AC; Ulukpo O; Rigby M; Pelaez A; Ramirez A; Gal AA; Force SD; Lawrence EC; Kirk AD -
LIMITED IMPACT OF ACUTE REJECTION ON GRAFT OUTCOMES IN BELATACEPT-TREATED KIDNEY TRANSPLANT RECIPIENTS (BENEFIT/BENEFIT-EXT)
TRANSPLANT INTERNATIONAL Volume: 22 Page(s): 193 - 193
08/01/2009 Authors: Larsen C; Vincenti F; Grinyo JM; Charpentier B; Di Russo GB; Garg P; Dong Y -
PRIMARY OUTCOMES FROM A RANDOMIZED, PHASE III STUDY OF BELATACEPT VS CYCLOSPORINE IN KIDNEY TRANSPLANT RECIPIENTS (BENEFIT STUDY)
TRANSPLANT INTERNATIONAL Volume: 22 Page(s): 89 - 89
08/01/2009 Authors: Vincenti F; Grinyo JM; Charpentier B; Medina-Pestana JD; Rostaing L; Vanrenterghem Y; Di Russo GB; Garg P; Lin C-S; Larsen C -
ONE YEAR SAFETY PROFILE OF BELATACEPT IN KIDNEY TRANSPLANT PATIENTS FROM THE BENEFIT AND BENEFIT-EXT STUDIES
TRANSPLANT INTERNATIONAL Volume: 22 Page(s): 90 - 90
08/01/2009 Authors: Larsen C; Charpentier B; Grinyo JM; Medina-Pestana JD; Vanrenterghem Y; Vincenti F; Thomas D; Di Russo GB; Shi R -
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
J Immunol Volume: 183 Page(s): 1625 - 1635
08/01/2009 Authors: Gilson CR; Milas Z; Gangappa S; Hollenbaugh D; Pearson TC; Ford ML; Larsen CP -
PRIMARY OUTCOMES FROM A RANDOMIZED, PHASE III STUDY OF BELATACEPT VS CYCLOSPORINE IN ECD KIDNEY TRANSPLANTS (BENEFIT-EXT STUDY)
TRANSPLANT INTERNATIONAL Volume: 22 Page(s): 89 - 89
08/01/2009 Authors: Durrbach A; Larsen C; Medina-Pestana JD; Vanrenterghem Y; Vincenti F; Florman S; Block AJ; Garg P; Sen K; Grinyo JM -
mTOR regulates memory CD8 T-cell differentiation.
Nature Volume: 460 Page(s): 108 - 112
07/02/2009 Authors: Araki K; Turner AP; Shaffer VO; Gangappa S; Keller SA; Bachmann MF; Larsen CP; Ahmed R -
Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.
Nat Med Volume: 15 Page(s): 746 - 749
07/01/2009 Authors: Weaver TA; Charafeddine AH; Agarwal A; Turner AP; Russell M; Leopardi FV; Kampen RL; Stempora L; Song M; Larsen CP -
CD28/154 Blockade Disrupts the Development of Diabetogenic T Cells while Permitting Regulatory T Cell Expansion
Volume: 58 Page(s): A324 - A324
06/01/2009 Authors: Rigby MB; Huang A; Duan D; Kirk AD; Larsen CP -
Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.
Transplantation Volume: 87 Page(s): S69 - S74
05/15/2009 Authors: Ford ML; Kirk AD; Larsen CP -
Translating costimulation blockade to the clinic: lessons learned from three pathways.
Immunol Rev Volume: 229 Page(s): 294 - 306
05/01/2009 Authors: Ford ML; Larsen CP -
Surgical Repair of Gastroesophageal Reflux in Lung Transplant Recipients Is Associated with Decreased Armed Effector T Cells and increased Exhausted T Cells within the Allograft
Volume: 28 Page(s): S224 - S224
02/01/2009 Authors: Neujabr DC; Pelaez A; Ramirez A; Force SD; Lawrence EC; Cardona AC; Kirk AD; Larsen CP -
PREVENTION OF ACUTE GVHD DURING HAPLO-BMT: EVALUATING THE EFFICACY OF T-CELL COSTIMULATION BLOCKADE USING A NOVEL RHESUS MACAQUE TRANSPLANT MODEL
Volume: 15 Page(s): 114 - 115
02/01/2009 Authors: Miller WP; Wheeler CE; Panoskaltsis-Mortari A; Kirk AD; Larsen CP; Blazar BR; Kean LS -
2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR).
Cell Transplant Volume: 18 Page(s): 753 - 767
01/01/2009 Authors: CITR Research Group -
Impact of CD40/CD154 Pathway Blockade on Donor-Reactive T Cell Expansion and Differentiation.
Volume: 9 Page(s): 631 - 631
01/01/2009 Authors: Ferrer IR; Hanna SS; Kirk AD; Ford ML; Larsen CP -
Total Pancreatectomy and Autologous Islet Transplantation for Chronic Pancreatitis: Long Term Assesment of Graft Function.
Volume: 9 Page(s): 712 - 712
01/01/2009 Authors: Agarwal A; Avila JG; Turgeon NA; Sears MH; Turner AP; Russell MC; Sarimento J; Kirk AD; Pearson TC; Larsen CP -
Transmission of Latent Viruses in Islet Cell Transplantation.
Volume: 9 Page(s): 405 - 405
01/01/2009 Authors: Mehta AK; Avila JG; Hendrix RC; Agarwal A; Kirk AD; Pearson TC; Larsen CP -
Alemtuzumab-Mediated Depletion in CD52 Transgenic (Tg) Mice: A Model of Memory-Dominant, Lymphopenic Allograft Rejection.
Volume: 9 Page(s): 541 - 542
01/01/2009 Authors: Ahmed Z; Charafeddine A; Hanna S; Weaver TA; Iwakoshi NN; Kean LS; Ford ML; Larsen CP; Kirk AD -
Impact of Naive Donor-Reactive Precursor Frequency on the Differentiation of Costimulation-Independent CD8+Memory T Cells.
Volume: 9 Page(s): 333 - 333
01/01/2009 Authors: Ford ML; Floyd TL; Wagener ME; Hanna SS; Stempora L; Hendrix R; Kirk AD; Larsen CP -
Optimization of Neonatal Porcine Pancreatic Islets for Transplantation by the Use of a Novel Bioreactor Device during Cell Culture.
Volume: 9 Page(s): 669 - 669
01/01/2009 Authors: Avila JG; Saif A-M; Cano JA; Iwakoshi N; Kirk AD; Pearson T; Sambanis A; Larsen CP -
Overcoming the Memory Barrier: Role of Anti-LFA-1 in Promoting Long-Term Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells.
Volume: 9 Page(s): 536 - 536
01/01/2009 Authors: Ford ML; Wagener ME; Cooper SS; Kirk AD; Larsen CP -
One Year Safety Profile of Belatacept in Kidney Transplant Patients from the BENEFIT and BENEFIT-EXT Studies
Volume: 9 Page(s): 495 - 495
01/01/2009 Authors: Larsen C; Charpentier B; Grinyo JM; Medina-Pestana JD; Vanrenterghem Y; Vincenti F; Thomas D; Di Russo GB; Shi R -
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
J Immunol Volume: 182 Page(s): 225 - 233
01/01/2009 Authors: Coley SM; Ford ML; Hanna SC; Wagener ME; Kirk AD; Larsen CP -
Effects of MHC Matching on Polyoma Virus Nephropathy (PVN).
Volume: 9 Page(s): 378 - 378
01/01/2009 Authors: Dong Y; Lin E; Wang J; Breeden C; Larsen CP; Lukacher AE; Newell KA -
Selective Targeting of Antigen Experienced Memory T Cells with LFA3-IG: The Role of CD2 Cell Surface Density.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 9 Page(s): 537 - 537
01/01/2009 Authors: Weaver T; Charafeddine A; Turner A; Agarwal A; Russell M; Badell I; Stempora L; Larsen C; Kirk A -
Graft-Specific Action of IFN gamma Maintains Allograft Survival after Costimulation Blockade.
Volume: 9 Page(s): 718 - 718
01/01/2009 Authors: Coley SM; Swygert SG; Song M; Kirk AD; Larsen CP -
Dynamic Hypercoagulability Following Pancreas Transplantation.
Volume: 9 Page(s): 616 - 617
01/01/2009 Authors: Shen L; Agarwal A; Turgeon N; Tso P; Newell K; Pearson T; Larsen C; Winkler A; Duncan A; Kirk A -
Impact of Rabbit Anti-Thymocyte Globulin Induction Therapy on Reactivation of BK Virus in Renal Transplant Recipients.
Volume: 9 Page(s): 422 - 422
01/01/2009 Authors: Agarwal A; Metha A; Kokko K; Turgeon NA; Tso PY; Newell KA; Larsen CP; Kirk AD -
LFA-3-Ig (Alefacept) Prolongs Allograft Survival by Targeting Costimulation Blockade Resistant T Effector Memory Cells in Non-Human Primate Islet Transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 9 Page(s): 237 - 237
01/01/2009 Authors: Turner AP; Weaver T; Badell R; Cano J; Avila J; Turner P; Leopardi F; Strobert E; Larsen CP; Kirk AD -
The Impact of MHC-Disparity on Alloreactive CD8+T Cell Precursor Frequency: Unexpected Similarities between Unrelated and Haplo-Identical Transplant Pairs.
Volume: 9 Page(s): 486 - 486
01/01/2009 Authors: Page A; Hamby K; Kirk A; Larsen C; Kean L -
Macrophage Gene Expression Is Skewed toward M1 Polarization in Acute Rejection Following Human Lung Transplantation.
Volume: 9 Page(s): 213 - 214
01/01/2009 Authors: Mohammed A; Lam G; Cardona AC; Pelaez A; Lawrence EC; Ramirez AD; Force SD; Kirk AD; Larsen CP; Neujahr DC -
Development of a Novel Immunosuppressive Regimen To Facilitate Single Donor Islet Cell Transplantation Using Efalizumab.
Volume: 9 Page(s): 321 - 321
01/01/2009 Authors: Turgeon NA; Avila JG; Agarwal A; Cano JA; Holbrook EB; Sears MH; Bowen PH; Kirk AD; Pearson TC; Larsen CP -
A Novel Anti-LFA-1-Based Therapy Enhances Allogeneic Islet Survival and Function in Nonhuman Primates.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 9 Page(s): 367 - 367
01/01/2009 Authors: Badell I; Russell M; Turner A; Avila J; Cano J; Johnson B; Strobert E; Kirk A; Larsen C -
Rapamycin Enhances the Magnitude and Quality of Viral-Specific CD8+T Cell Responses to Vaccinia Virus Vaccination in the Rhesus Macaque.
Volume: 9 Page(s): 623 - 623
01/01/2009 Authors: Turner AP; Shaffer V; Martens C; Turner P; Hendrix R; Stempora L; Gangappa S; Kirk AD; Larsen CP -
A Single Center Comparison between Basiliximab and Rabbit Anti-Thymocyte Globulin Induction Therapy for Simultaneous Pancreas and Kidney Transplantation.
Volume: 9 Page(s): 547 - 547
01/01/2009 Authors: Shen L; Turgeon N; Tso P; Newell K; Pearson T; Larsen C; Kirk A -
Identification of Critical Factors Leading to Successful Islet Isolations and Transplantation.
Volume: 9 Page(s): 403 - 404
01/01/2009 Authors: Avila JG; Agarwal A; Turgeon N; Cano JA; Turner A; Russell MC; Kirk AD; Pearson T; Larsen CP -
Time Profiles of Specific Physiologic and Genetic Parameters of Neonatal Porcine Pancreatic Islets.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 9 Page(s): 469 - 469
01/01/2009 Authors: Avila JG; Cano JA; Agarwal A; Iwakoshi N; Matar A; Russell MC; Turner A; Badell IR; Korbutt G; Rayat G -
Prevention of Acute GvHD during Haplo-BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model.
Volume: 9 Page(s): 225 - 225
01/01/2009 Authors: Miller W; Wheeler C; Panoskaltsis-Mortari A; Kirk A; Larsen CP; Blazar BR; Kean L -
Anti-LFA-1 and CTLA-4 Ig Synergize in Attenuating Donor-Reactive CD4+and CD8+T Cell Responses and in Prolonging Graft Survival.
Volume: 9 Page(s): 539 - 539
01/01/2009 Authors: Reisman NM; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Development of Novel Technologies for Monitoring Allospecific Humoral Immunity in a Non-Human Primate Model.
Volume: 9 Page(s): 703 - 703
01/01/2009 Authors: Agarwal A; Leopardi FV; Weaver TA; Iwakoshi NN; Larsen CP; Kirk AD -
Activation and Expansion of Functional Regulatory T Cells during Antigen Encounter While Blocking CD28 and CD154.
Volume: 9 Page(s): 629 - 629
01/01/2009 Authors: Rigby M; Duan D; Kirk A; Larsen C -
Novel Functional Assays of Human Allospecific Peripheral Memory B Cells Demonstrating Allospecific Antibody Production.
Volume: 9 Page(s): 471 - 471
01/01/2009 Authors: Agarwal A; Turgeon NA; Smith KM; Mendel JB; Larsen CP; Kirk AD; Iwakoshi NN -
Primary Outcomes from a Randomized, Phase III Study of Belatacept vs Cyclosporine in ECD Kidney Transplants (BENEFIT-EXT Study).
Volume: 9 Page(s): 199 - 199
01/01/2009 Authors: Durrbach A; Larsen C; Medina-Pestana JD; Vanrenterghem Y; Vincenti F; Florman S; Block AJ; Garg P; Sen K; Grinyo J -
Distribution of Alloreactivity within CD8(+) T Cell Subsets in the Rhesus Macaque.
Volume: 9 Page(s): 473 - 473
01/01/2009 Authors: Turner A; Weaver T; Stempora L; Iwakoshi N; Ford M; Kirk A; Larsen C -
HUMAN LEUKOCYTE ANTIGEN-DR (HLA-DR) EXPRESSION ON MONOCYTES, NEUTROPHILS, AND LYMPHOCYTES DURING PEDIATRIC CRITICAL ILLNESS: IMMUNOPARALYSIS VERSUS IMMUNE ACTIVATION.
Volume: 36 Page(s): A112 - A112
12/01/2008 Authors: Crain FE; Neujahr DC; Larsen CP; Rigby MR -
Prevention of Acute GvHD during Haplo-BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model
Volume: 112 Page(s): 1207 - 1207
11/16/2008 Authors: Miller W; Wheeler CE; Panoskaltsis-Mortari A; Kirk A; Larsen CP; Blazar BR; Kean L -
Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.
Am J Transplant Volume: 8 Page(s): 2252 - 2264
11/01/2008 Authors: Anderson A; Martens CL; Hendrix R; Stempora LL; Miller WP; Hamby K; Russell M; Strobert E; Blazar BR; Pearson TC -
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
J Immunol Volume: 181 Page(s): 5313 - 5322
10/15/2008 Authors: Koehn BH; Ford ML; Ferrer IR; Borom K; Gangappa S; Kirk AD; Larsen CP -
CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.
Diabetes Volume: 57 Page(s): 2672 - 2683
10/01/2008 Authors: Rigby MR; Trexler AM; Pearson TC; Larsen CP -
Kidney transplantation: structural and functional evaluation using MR Nephro-Urography.
J Magn Reson Imaging Volume: 28 Page(s): 805 - 822
10/01/2008 Authors: Kalb B; Martin DR; Salman K; Sharma P; Votaw J; Larsen C -
Measuring symptom experience of side-effects of immunosuppressive drugs: the Modified Transplant Symptom Occurrence and Distress Scale.
Transpl Int Volume: 21 Page(s): 764 - 773
08/01/2008 Authors: Dobbels F; Moons P; Abraham I; Larsen CP; Dupont L; De Geest S -
A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
J Immunol Volume: 180 Page(s): 7203 - 7211
06/01/2008 Authors: Ford ML; Wagener ME; Hanna SS; Pearson TC; Kirk AD; Larsen CP -
Blocking CD28 or LFA-1, but not CD154, signaling results in abortive activation of antigen-stimulated T cells
Volume: 57 Page(s): A351 - A352
06/01/2008 Authors: Rigby MR; Trexler A; Bello-Laborn H; Kean L; Kirk AD; Pearson TC; Larsen CP -
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.
Nature Volume: 453 Page(s): 667 - 671
05/29/2008 Authors: Wrammert J; Smith K; Miller J; Langley WA; Kokko K; Larsen C; Zheng N-Y; Mays I; Garman L; Helms C -
A critical precursor frequency of donor-reactive CD4+T cell help is required for CD8+T cell-mediated costimulation blockade-resistant rejection
Volume: 8 Page(s): 618 - 618
05/01/2008 Authors: Ford ML; Wagener MS; Hanna SS; Pearson TC; Larsen CP -
A novel costimulation blockade regimen for engraftment and function of allogeneic islets in diabetic rhesus macaques.
Volume: 8 Page(s): 228 - 229
05/01/2008 Authors: Russell MC; Cardona K; Oliva VL; Turner AP; Cano J; Avila J; Jiang W; Leopardi F; Johnson B; Scott E -
Incidence and prognosis of Pneumocystis jiroveci pneumonia following kidney transplantation in the modern era
Volume: 8 Page(s): 526 - 526
05/01/2008 Authors: Kim HJ; Wrammert J; Larsen CP; Ahmed R; Kokko KE -
Tregs undergo basal proliferation that is dependant on CD28 : B7, but not CD154 : CD40, signaling which can be accentuated by self-peptide
Volume: 8 Page(s): 625 - 626
05/01/2008 Authors: Rigby MR; Bello-Laborn H; Trexler AM; Kean L; Kirk AD; Pearson TC; Larsen CP -
Depletion of CD16+ cells leads to increased survival of CFSE-labeled peripheral blood stem cells in rhesus macaques
Volume: 8 Page(s): 485 - 485
05/01/2008 Authors: Kean L; Charaffedine A; Hamby K; Stempora L; Pearson TC; Kirk A; Larsen CP -
Impact of immunosuppression reduction in BK viremic patients: 3 year follow-up
Volume: 8 Page(s): 284 - 284
05/01/2008 Authors: Kuppachi S; Guasch A; Larsen CP; Kokko KE -
Targeting of costimulation blockade resistant T effector memory (TEM) cells in non-human primate renal transplantation with LFA-3-Ig (alefacept) prolongs allograft survival
Volume: 8 Page(s): 204 - 205
05/01/2008 Authors: Weaver TA; Charafeddine AH; Agarwal A; Leopardi F; Kampen R; Starost MF; Larsen CP; Kirk AD -
Relevance of donor specific antibodies in simultaneous liver kidney transplantation
Volume: 8 Page(s): 378 - 378
05/01/2008 Authors: Agarwal A; Shen LY; Kokko KE; Bray RA; Gebel HM; Pearson TC; Larsen CP; Kirk AD -
Characterization of the magnitude and quality of response to vaccinia virus vaccination in immunosuppressed rhesus macaques
Volume: 8 Page(s): 625 - 625
05/01/2008 Authors: Turner AP; Oliva VL; Turner PL; Gangappa S; Larsen CP -
Laparoscopic donor nephrectomy: Multiple arteries are not a predictor of recipient outcomes.
Volume: 8 Page(s): 457 - 457
05/01/2008 Authors: Bearden CM; Tso PL; Turgeon NA; Ogan K; Pearson TC; Kirk AD; Larsen CP; Newell KA -
Antagonism of signaling through CD28 or LFA-1, but not CD154, result in abortive activation of antigen-stimulated T cells
Volume: 8 Page(s): 624 - 624
05/01/2008 Authors: Rigby MR; Trexler AM; Bello-Labom H; Kirk AD; Pearson TC; Kean L; Larsen CP -
Development of a neonatal porcine islet isolation procedure with successful transplantation outcomes
Volume: 8 Page(s): 551 - 551
05/01/2008 Authors: Avila J; Cano J; Holbrook E; Russel M; Iwakoshi N; Turner A; Agarwal A; Kirk A; Larsen C -
Impact of rabbit anti-thymocyte globulin induction therapy on reactivation of BK virus in renal transplant recipients.
Volume: 8 Page(s): 460 - 460
05/01/2008 Authors: Agarwal A; Meetha A; Kokko KE; Turgeon NA; Tso PL; Newell KA; Pearson TC; Larsen CP; Kirk AD -
High level chimerism in rhesus macaques after nonmyelabaltive transplantation and anti-CD40-based immunoodulation
Volume: 8 Page(s): 485 - 485
05/01/2008 Authors: Kean LS; Hamby K; Deane T; Stempora L; Pearson TC; Kirk A; Larsen CP -
Breakthrough rejection under costimulation blockade aided by IFN gamma receptor
Volume: 8 Page(s): 483 - 483
05/01/2008 Authors: Coley S; Hanna S; Larsen CP -
Linked antigen-specific high frequency T cells augment effector activity but not accumulation of low frequency CD8+ donor-reactive T cell responses following CD28/CD154 blockade.
Volume: 8 Page(s): 418 - 418
05/01/2008 Authors: Ford ML; Wagener ME; Kirk AD; Larsen CP -
Influenza vaccination in renal transplant patients: A defect in peripheral antibody secreting cells (ASC)
Volume: 8 Page(s): 526 - 526
05/01/2008 Authors: Kim HJ; Wrammer J; Larsen CP; Ahmed R; Kokko KE -
CD8+ memory T cells specific for a single surrogate minor antigen are sufficient to inhibit transplant tolerance induced by CTLA-4 ig and anti-CD154
Volume: 8 Page(s): 293 - 293
05/01/2008 Authors: Ford ML; Steeds CM; Wagener ME; Kirk AD; Larsen CP -
Islet cell transplantation using surgical cannulation of the portal vein followed by delayed conversion to a MMF and tacrolimus immunosuppressive regimen
Volume: 8 Page(s): 431 - 432
05/01/2008 Authors: Rigby MR; Kokko K; Turgeon N; Sears M; Bowen PH; Avila J; Holbrook E; Kirk AD; Pearson TC; Larsen CP -
Combined liver-kidney transplantation across a positive flow crossmatch: A cause for concern?
Volume: 8 Page(s): 337 - 337
05/01/2008 Authors: Shen LY; Agarwal A; Turgeon NA; Larsen CP; Pearson TC; Bray RA; Gebel HM; Kirk AD; Kokko KE -
Influence of donor type on elderly kidney transplant survival and allograft function
Volume: 8 Page(s): 531 - 532
05/01/2008 Authors: Shen LY; Kuppachi S; Turgeon NA; Pearson TC; Larsen CP; Kirk AD -
Protective Immunity in Transplant Recipients
Volume: 22
04/01/2008 Authors: Mulupuri P; Gourley T; Popkowski A; Mehta A; Begley B; Breeden C; Larsen C; Ahmed R -
Immune responsiveness and protective immunity after transplantation.
Transpl Int Volume: 21 Page(s): 293 - 303
04/01/2008 Authors: Gangappa S; Kokko KE; Carlson LM; Gourley T; Newell KA; Pearson TC; Ahmed R; Larsen CP -
Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.
J Immunol Volume: 180 Page(s): 3190 - 3200
03/01/2008 Authors: Stapler D; Lee ED; Selvaraj SA; Evans AG; Kean LS; Speck SH; Larsen CP; Gangappa S -
Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.
Gastroenterology Volume: 134 Page(s): 727 - 737
03/01/2008 Authors: Mwangi S; Anitha M; Mallikarjun C; Ding X; Hara M; Parsadanian A; Larsen CP; Thule P; Sitaraman SV; Anania F -
Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity.
Transplantation Volume: 85 Page(s): 118 - 124
01/15/2008 Authors: Emamaullee JA; Merani S; Larsen CP; Shapiro AMJ -
Immunosuppressive protocols for pig-to-human islet transplantation: lessons from pre-clinical non-human primate models.
Xenotransplantation Volume: 15 Page(s): 107 - 111
01/01/2008 Authors: Gangappa S; Larsen CP -
A consensus document based on the Pig-to-Man Islet Transplant Summit held in Stockholm, June 4-5, 2007.
Xenotransplantation Volume: 15 Page(s): 79
01/01/2008 -
MHC-matched stem cell transplantation in rhesus macaques using a costimulation blockade-based immunomodulation platform
Volume: 110 Page(s): 361A - 361A
11/16/2007 Authors: Kean LS; Hamby K; Deane T; Pearson TC; Larsen CP -
Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.
Am J Transplant Volume: 7 Page(s): 2260 - 2268
10/01/2007 Authors: Cardona K; Milas Z; Strobert E; Cano J; Jiang W; Safley SA; Gangappa S; Hering BJ; Weber CJ; Pearson TC -
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
Proc Natl Acad Sci U S A Volume: 104 Page(s): 15430 - 15435
09/25/2007 Authors: Mueller SN; Matloubian M; Clemens DM; Sharpe AH; Freeman GJ; Gangappa S; Larsen CP; Ahmed R -
Engraftment of neonatal porcine islets in diabetic non-human primates by blockade of the CD28/CD40 costimulatory pathways
Volume: 14 Page(s): 423 - 423
09/01/2007 Authors: Russell MC; Cardona K; Oliva VL; Korbutt GS; Cano J; Jiang W; Strobert E; Rajotte RV; Pearson TC; Larsen CP -
Total pancreatectomy and autologous islet transplantation for chronic pancreatitis: The Emory Experience
Volume: 14 Page(s): 472 - 472
09/01/2007 Authors: Russell M; Cardona K; Oliva V; Sears M; Holbrook E; Cano J; Sarmiento J; Pearson T; Larsen C -
Interim report of phase 2 long-term safety of belatacept
TRANSPLANT INTERNATIONAL Volume: 20 Page(s): 74 - 74
09/01/2007 Authors: Vincenti F; Larsen C; Muehlbacher F; Charpentier B -
Pharmacokinetics of belatacept in renal transplant patients
Volume: 47 Page(s): 1203 - 1203
09/01/2007 Authors: Girgis S; Vincenti F; Larsen C; Grinyo J; Shapiro J; You X; Vakkalagadda B; Park J-S; Dong H; Geng D -
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Blood Volume: 110 Page(s): 1199 - 1206
08/15/2007 Authors: Singh N; Chandler PR; Seki Y; Baban B; Takezaki M; Kahler DJ; Munn DH; Larsen CP; Mellor AL; Iwashima M -
Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
J Immunol Volume: 179 Page(s): 2616 - 2626
08/15/2007 Authors: Koehn BH; Williams MA; Borom K; Gangappa S; Pearson TC; Ahmed R; Larsen CP -
NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.
Am J Transplant Volume: 7 Page(s): 1884 - 1896
08/01/2007 Authors: Hamby K; Trexler A; Pearson TC; Larsen CP; Rigby MR; Kean LS -
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Transplantation Volume: 84 Page(s): 196 - 206
07/27/2007 Authors: Zahorchak AF; Kean LS; Tokita D; Turnquist HR; Abe M; Finke J; Hamby K; Rigby MR; Larsen CP; Thomson AW -
Transplantation tolerance.
Semin Nephrol Volume: 27 Page(s): 487 - 497
07/01/2007 Authors: Newell KA; Larsen CP -
Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.
Am J Transplant Volume: 7 Page(s): 1471 - 1481
06/01/2007 Authors: Ford ML; Wagener ME; Gangappa S; Pearson TC; Larsen CP -
Patient factors associated with a faster insertion of the colonoscope.
Surg Endosc Volume: 21 Page(s): 885 - 888
06/01/2007 Authors: Arcovedo R; Larsen C; Reyes HS -
Antigenic disparity impacts efficacy of agonism but not blockade of costimulatory pathways in experimental transplant models.
Volume: 7 Page(s): 202 - 202
05/01/2007 Authors: Ford ML; Wagener ME; Gangappa S; Pearson TC; Larsen CP -
On the role of virus-specific TCRV beta 4+CD8+ T cells in latent infection mediated interference with transplantation tolerance.
Volume: 7 Page(s): 303 - 303
05/01/2007 Authors: Stapler DC; Lee E; Speck SH; Pearson TC; Larsen CP; Gangappa S -
Transplantation tolerance through blockade of the CD40/CD401 costimulation pathway using alpha CD40 isotypes IgG1 and IgG2b.
Volume: 7 Page(s): 486 - 486
05/01/2007 Authors: Gilson CR; Milas Z; Gangappa S; Pearson TC; Larsen CP -
Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy.
Volume: 94 Page(s): 546 - 554
05/01/2007 Authors: Reddy BS; Macfie J; Gatt M; Larsen CN; Jensen SS; Leser TD -
Expansion and suppressive function of rhesus macaque regulatory T cells.
Volume: 7 Page(s): 478 - 478
05/01/2007 Authors: Anderson AR; Kean L; Stempora L; Gangappa S; Larsen C -
Interim report of phase 2 long-term safety of belatacept.
Volume: 7 Page(s): 182 - 183
05/01/2007 Authors: Charpentier B; Muehlbacher F; Larsen C; Vincenti F -
Antigen-specific precursor frequency critically impacts CD8+T cell proliferation. differentiation, and requirement for costimulation.
Volume: 7 Page(s): 223 - 223
05/01/2007 Authors: Ford ML; Koehn BH; Wagener ME; Jiang W; Ganappa S; Pearson TC; Larsen CP -
Blockade of the CD28/CD40 costimulatory pathways allows engraftment and function of neonatal porcine islets in diabetic non-human primates.
Volume: 7 Page(s): 223 - 223
05/01/2007 Authors: Cardona K; Oliva VL; Russell MC; Korbutt GS; Cano J; Jiang W; Strobert E; Gangappa S; Pearson TC; Rajotte RV -
Interferon gamma: Unexpected benefits for graft survival.
Volume: 7 Page(s): 221 - 221
05/01/2007 Authors: Coley SM; Gangappa S; Pearson TC; Larsen CP -
Early effects of CD28/CD40 blockade on programmed T cell responses.
Volume: 7 Page(s): 488 - 488
05/01/2007 Authors: Koehn B; Yates A; Gangappa S; Larsen CP -
Transgenic mice over expressing glial derived neurotrophic factor have increased beta cell mass
Volume: 21 Page(s): A1314 - A1315
04/01/2007 Authors: Mwangi S; Mallikarjun C; Ding X; Hara M; Parsadanian A; Larsen CP; Thule P; Anania F; Sitaraman S; Srinivasan S -
Influence of glial cell line-derived neutotrophic factor and the enteric nervous system on beta-cell mass and glucose homeostasis
Volume: 132 Page(s): A722 - A722
04/01/2007 Authors: Mwangi S; Mallikarjun C; Ding X; Hara M; Parsadanian A; Larsen CP; Thule P; Anania FA; Sitaraman SV; Srinivasan S -
Functionally impaired T cell-dependent immunopathology in FK506-treated mice with LCMV infection
JOURNAL OF IMMUNOLOGY Volume: 178
04/01/2007 Authors: Araki K; Gangappa S; Rouse BT; Larsen CP; Ahmed R -
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
J Exp Med Volume: 204 Page(s): 299 - 309
02/19/2007 Authors: Ford ML; Koehn BH; Wagener ME; Jiang W; Gangappa S; Pearson TC; Larsen CP -
Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
Am J Transplant Volume: 7 Page(s): 320 - 335
02/01/2007 Authors: Kean LS; Adams AB; Strobert E; Hendrix R; Gangappa S; Jones TR; Shirasugi N; Rigby MR; Hamby K; Jiang J -
Frequency of FOXP3+ regulatory CD4 cells recovered in bronchoalveolar lavage does not predict acute rejection score
JOURNAL OF HEART AND LUNG TRANSPLANTATION Volume: 26 Page(s): S73 - S73
02/01/2007 Authors: Neujhar DC; Lawrence EC; Pelaez A; Ramirez A; Force S; Gal A; Larsen CP -
Alloimmunity: no toll exemption.
Am J Transplant Volume: 7 Page(s): 3 - 4
01/01/2007 Authors: Gangappa S; Larsen CP; Pearson TC -
Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.
Biol Blood Marrow Transplant Volume: 12 Page(s): 1239 - 1249
12/01/2006 Authors: Li J-M; Gorechlad J; Larsen CP; Waller EK -
Apoptotic cells break tolerance induced by CD40-CD40L blockade.
Volume: 108 Page(s): 919A - 919A
11/16/2006 Authors: Li J-M; Gorechlad JW; Giver C; Larsen CP; Waller N -
Establishment of chimerism in Rhesus macaques through nonmyeloablative hematopoietic stem cell transplant and costimulation blockade-based immunosuppression.
Volume: 108 Page(s): 914A - 914A
11/16/2006 Authors: Kean L; Adams A; Strobert E; Pearson T; Larsen C -
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
J Exp Med Volume: 203 Page(s): 2263 - 2269
10/02/2006 Authors: Vezys V; Masopust D; Kemball CC; Barber DL; O'Mara LA; Larsen CP; Pearson TC; Ahmed R; Lukacher AE -
Transplanting the highly sensitized patient: The emory algorithm.
Am J Transplant Volume: 6 Page(s): 2307 - 2315
10/01/2006 Authors: Bray RA; Nolen JDL; Larsen C; Pearson T; Newell KA; Kokko K; Guasch A; Tso P; Mendel JB; Gebel HM -
Objective assessment of gynecologic laparoscopic skills using the LapSimGyn virtual reality simulator.
Surg Endosc Volume: 20 Page(s): 1460 - 1466
09/01/2006 Authors: Larsen CR; Grantcharov T; Aggarwal R; Tully A; Srensen JL; Dalsgaard T; Ottesen B -
Toward transplantation tolerance: a large step on a long road.
Am J Transplant Volume: 6 Page(s): 1989 - 1990
09/01/2006 Authors: Newell KA; Larsen CP -
Tolerance assays: measuring the unknown.
Transplantation Volume: 81 Page(s): 1503 - 1509
06/15/2006 Authors: Newell KA; Larsen CP -
Transplant tolerance in non-human primates: progress, current challenges and unmet needs.
Am J Transplant Volume: 6 Page(s): 884 - 893
05/01/2006 Authors: Kean LS; Gangappa S; Pearson TC; Larsen CP -
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
Am J Transplant Volume: 6 Page(s): 876 - 883
05/01/2006 Authors: Larsen CP; Knechtle SJ; Adams A; Pearson T; Kirk AD -
A mouse model for polyomavirus-associated nephropathy of kidney transplants.
Am J Transplant Volume: 6 Page(s): 913 - 922
05/01/2006 Authors: Han Lee ED; Kemball CC; Wang J; Dong Y; Stapler DC; Hamby KM; Gangappa S; Newell KA; Pearson TC; Lukacher AE -
Long-term function of microeneapsulated human islets in diabetic mice
Volume: 176 Page(s): S168 - S168
04/01/2006 Authors: Safley S; Cui H; Tucker-Burden C; Cauffiel S; Cano J; Holbrook E; Cardona K; Larsen C; Weber C -
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
Nat Med Volume: 12 Page(s): 304 - 306
03/01/2006 Authors: Cardona K; Korbutt GS; Milas Z; Lyon J; Cano J; Jiang W; Bello-Laborn H; Hacquoil B; Strobert E; Gangappa S -
Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation.
J Immunol Volume: 176 Page(s): 2691 - 2696
03/01/2006 Authors: Koehn B; Gangappa S; Miller JD; Ahmed R; Larsen CP -
Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells.
Transplantation Volume: 81 Page(s): 455 - 462
02/15/2006 Authors: Emmanouilidis N; Guo Z; Dong Y; Newton-West M; Adams AB; Lee EDH; Wang J; Pearson TC; Larsen CP; Newell KA -
Apoptotic donor leukocytes inhibit tolerance and limit mixed chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation
Volume: 12 Page(s): 80 - 80
02/01/2006 Authors: Li JM; Giver CR; Gorechlad J; Larsen CP; Walker EK -
NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.
Am J Transplant Volume: 6 Page(s): 292 - 304
02/01/2006 Authors: Kean LS; Hamby K; Koehn B; Lee E; Coley S; Stempora L; Adams AB; Heiss E; Pearson TC; Larsen CP -
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.
J Immunol Volume: 176 Page(s): 1814 - 1824
02/01/2006 Authors: Kemball CC; Lee EDH; Szomolanyi-Tsuda E; Pearson TC; Larsen CP; Lukacher AE -
Transplant tolerance: converging on a moving target.
Transplantation Volume: 81 Page(s): 1 - 6
01/15/2006 Authors: Newell KA; Larsen CP; Kirk AD -
Long-term survival of neonatal porcine islet xenografts in diabetic non-human primates by targeting costimulation pathways.
Volume: 119 Page(s): S40 - S40
01/01/2006 Authors: Cardona K; Korbutt G; Milas Z; Lyon J; Cano J; Jiang W; Bello H; Strobert E; Gangappa S; Pearson T -
CD99 immunoreactivity in the evolution of mycosis fungoides
Volume: 86 Page(s): 83A - 83A
01/01/2006 Authors: Larsen CP; Smoller BR; Hiatt KM -
A role for PD-1 in maintaining peripheral tolerance to an allogeneic skin graft.
Volume: 119 Page(s): S100 - S100
01/01/2006 Authors: Koehn B; Borom K; Gangappa S; Pearson T; Larsen C -
Inhibition of T-cell activation by CD28 and CD40L blockade is influenced by T-cell precursor frequency.
Volume: 119 Page(s): S100 - S101
01/01/2006 Authors: Ford M; Koehn B; Waener M; Borom K; Gangappa S; Pearson T; Larsen C -
CD99 immunoreactivity in the evolution of mycosis fungoides
Volume: 19 Page(s): 83A - 83A
01/01/2006 Authors: Larsen CP; Smoller BR; Hiatt KM -
Expansion and suppressive function of rhesus macaque regulatory T-cells.
Volume: 119 Page(s): S101 - S101
01/01/2006 Authors: Anderson A; Kean L; Gangappa S; Larsen C -
Berkeley sickle mice demonstrate CD8- and NK1.1-dependent increased rejection of allogeneic hematopoietic stem cell transplants.
Volume: 106 Page(s): 656A - 656A
11/16/2005 Authors: Kean L; Hamby K; Perry J; Larsen C; Archerq D -
Costimulation blockade with belatacept in renal transplantation.
N Engl J Med Volume: 353 Page(s): 770 - 781
08/25/2005 Authors: Vincenti F; Larsen C; Durrbach A; Wekerle T; Nashan B; Blancho G; Lang P; Grinyo J; Halloran PF; Solez K -
Natural killer (NK) cells efficiently prevent engraftment of donor stem cells after tolerigenic bone marrow transplantation (vol 9, Suppl 6, pg 80, 2005)
PEDIATRIC TRANSPLANTATION Volume: 9 Page(s): 551 - 551
08/01/2005 Authors: Kean L; Hamby K; Coley S; Koehn B; Adams A; Pearson T; Larsen C -
Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.
J Immunol Volume: 174 Page(s): 7950 - 7960
06/15/2005 Authors: Kemball CC; Lee EDH; Vezys V; Pearson TC; Larsen CP; Lukacher AE -
Tolerance induction does not affect generating antiviral T cells during persistent infection.
Volume: 5 Page(s): 226 - 226
05/01/2005 Authors: Lee EDH; Kemball CC; Stapler DC; Lukacher AE; Gangappa S; Pearson TC; Larsen CP -
Single center experience with allograft pancreatectomy.
Volume: 5 Page(s): 358 - 358
05/01/2005 Authors: Tso PL; Newell KA; Pearson TC; Larsen CP -
Comparable graft survival in sensitized and unsensitized renal transplant recipients: A 5 year single center review.
Volume: 5 Page(s): 456 - 456
05/01/2005 Authors: Nolen JDL; Gebel HM; Larsen C; Pearson T; Newell K; Kokko K; Guasch A; Tso P; Bray RA -
Healthy individuals generate a predominantly CD4 response against polyoma virus BK.
Volume: 5 Page(s): 452 - 452
05/01/2005 Authors: Tong DC; Miller JD; Kokko KE; McLaughlin S; Lukacher AE; Gangappa S; Larsen CP -
Calcineurin inhibitor-free immunosuppression with belatacept (LEA29Y) in renal transplant: Phase II 12-month results.
Volume: 5 Page(s): 293 - 293
05/01/2005 Authors: Larsen C; Charpentier B; Wekerle T; Blancho G; Zhou W; Levy E; Vincenti F -
Prospective monitoring for BK viremia suggests improved outcomes in kidney transplant recipients.
Volume: 5 Page(s): 272 - 272
05/01/2005 Authors: Tong DC; Shivaprakash V; Baio K; Larsen CP; Kokko KE -
Deletional tolerance to a modelantigen.
Volume: 5 Page(s): 416 - 416
05/01/2005 Authors: Koehn B; Borom K; Gangappa S; Pearson TC; Larsen CP -
Innate immunity and transplantation tolerance: Defining the role of natural killer (NK) cells in allograft rejection
Volume: 5 Page(s): 212 - 212
05/01/2005 Authors: Kean L; Hamby K; Coley S; Lee E; Adams A; Heiss E; Pearson T; Larsen C -
The emory clinical islet transplant experience: Surgical and therapeutic success.
Volume: 5 Page(s): 359 - 360
05/01/2005 Authors: Milas Z; Adams A; Cano J; Holbrooke E; Sears M; Gangappa S; Pearson T; Larsen C -
Cultured islets from humans and non human primates produce significant amounts of biologically active interleukin 8
Volume: 5 Page(s): 309 - 309
05/01/2005 Authors: Milas Z; Adams A; Cano J; Gangappa S; Pearson T; Larsen C -
Anti-CD40 isotype IgG(2B) antibody induces murine chimerism and skin graft tolerance unlike anti-CD40 isotype IgG(1) antibody.
Volume: 5 Page(s): 228 - 228
05/01/2005 Authors: Milas Z; Adams A; Cardona K; Hamby K; Gangappa S; Pearson T; Larsen C -
CD4+T cell susceptibility to costimulation blockade-mediated tolerance is dependent on tcr affinity for peptide : MHC.
Volume: 5 Page(s): 366 - 366
05/01/2005 Authors: Ford ML; Koehn B; Borom K; Gangappa S; Pearson TC; Larsen CP -
Effects of latent viral infection on alloreactivity barrier in costimulation blockade-induced tolerance
Volume: 5 Page(s): 214 - 214
05/01/2005 Authors: Cardona K; Laclair C; Speck SH; Pearson TC; Larsen CP; Gangappa S -
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.
Am J Transplant Volume: 5 Page(s): 443 - 453
03/01/2005 Authors: Larsen CP; Pearson TC; Adams AB; Tso P; Shirasugi N; Strobert E; Anderson D; Cowan S; Price K; Naemura J -
Impaired recall of CD8 memory T cells in immunologically privileged tissue.
J Immunol Volume: 174 Page(s): 1165 - 1170
02/01/2005 Authors: Dai Z; Nasr IW; Reel M; Deng S; Diggs L; Larsen CP; Rothstein DM; Lakkis FG -
NK cell alloreactivity is an important mediator of costimulation-blockade-resistant rejection during allogeneic transplantation
Volume: 11 Page(s): 36 - 37
02/01/2005 Authors: Kean LS; Hamby K; Coley S; Lee E; Adams A; Pearson T; Larsen C -
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.
J Immunol Volume: 174 Page(s): 542 - 550
01/01/2005 Authors: Adams AB; Shirasugi N; Jones TR; Durham MM; Strobert EA; Cowan S; Rees P; Hendrix R; Price K; Kenyon NS -
Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice.
Methods Mol Med Volume: 109 Page(s): 459 - 468
01/01/2005 Authors: Emmanouilidis N; Larsen CP -
Costimulation requirements for polyomavirus-specific CD8+T cells differ between acute and persistent phases of infection
JOURNAL OF NEUROVIROLOGY Volume: 14 Page(s): 45 - 45
01/01/2005 Authors: Kemball CC; Lee EDH; Szomolanyi-Tsuda E; Pearson TC; Larsen CP; Lukacher AE -
Non-myeloablative bone marrow transplantation with T-cell costimulation blockade produces high level mixed-chimerism in non-human primates.
PEDIATRIC TRANSPLANTATION Volume: 9 Page(s): 94 - 94
01/01/2005 Authors: Kean L; Adams A; Hendrix R; Jiang J; Cardona K; Milas Z; Strobert E; Pearson T; Larsen C -
Natural killer ink cells efficiently prevent engraftment of donor stem cells after tolerigenic bone marrow transplantation.
PEDIATRIC TRANSPLANTATION Volume: 9 Page(s): 80 - 80
01/01/2005 Authors: Kean L; Hamby K; Coley S; Koehn B; Adams A; Pearson T; Larsen C -
A mouse model for polyomavirus-associated nephropathy of kidney transplants
JOURNAL OF NEUROVIROLOGY Volume: 14 Page(s): 41 - 41
01/01/2005 Authors: Lee EDH; Kemball CC; Wang J; Dong Y; Stapler DC; Hamby KM; Gangappa S; Newell KA; Pearson TC; Lukacher AE -
A 5 year single center review of graft survival in sensitized renal transplant recipients
Volume: 66 Page(s): S56 - S56
01/01/2005 Authors: Nolen JDL; Bray RA; Pearson T; Larsen C; Newell K; Kokko K; Guasch A; Tso P; Gebel HM -
Combined blockade of CD154 and CD28 T cell costimulatory pathways prevents diabetes in a murine model of type 1 diabetes mellitus.
PEDIATRIC TRANSPLANTATION Volume: 9 Page(s): 55 - 55
01/01/2005 Authors: Rigby MR; Trexler AM; Pearson TC; Larsen CP -
Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.
Transplant Proc Volume: 36 Page(s): 2423 - 2424
10/01/2004 Authors: Shirasugi N; Emmanouilidis N; Pearson TC; Larsen CP -
Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival.
Am J Transplant Volume: 4 Page(s): 526 - 536
04/01/2004 Authors: Nanji SA; Hancock WW; Anderson CC; Adams AB; Luo B; Schur CD; Pawlick RL; Wang L; Coyle AJ; Larsen CP -
Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication.
J Clin Invest Volume: 113 Page(s): 836 - 845
03/01/2004 Authors: Garber DA; Silvestri G; Barry AP; Fedanov A; Kozyr N; McClure H; Montefiori DC; Larsen CP; Altman JD; Staprans SI -
The CD134/CD134L pathway is critical in CD8-mediated costimulation blockade resistant rejection.
Volume: 4 Page(s): 440 - 440
01/01/2004 Authors: Adams AB; Jones TR; Heiss EA; Shirasugi N; Rees PA; Yagita H; Pearson TC; Larsen CP -
Anti-CD40 ligand antibody and anti-CD40 isotype IgG(2B) antibody induce equivalent murine chimerism and skin graft tolerance unlike anti-CD40 isotype IgG(1) antibody.
Volume: 4 Page(s): 581 - 581
01/01/2004 Authors: Milas ZL; Adams AB; Jones T; Durham M; Pearson TC; Larsen CP -
Co-stimulation blockade with LEA29Y in a calcineurin inhibitor free maintenance regimen in renal transplant: 6-month efficacy and safety
Volume: 4 Page(s): 442 - 442
01/01/2004 Authors: Vincenti F; Muehlbacher F; Nashan B; Larsen C; Atillasoy E; Natarajan K; Charpentier B -
Effect of latent infection on costimulation blockade-induced tolerance.
Volume: 4 Page(s): 302 - 302
01/01/2004 Authors: Gangappa S; Rees P; Laclair C; Adams AB; Heiss E; Speck SH; Pearson TC; Larsen CP -
Effects of hematopoietic chimerism on protective immunity.
Volume: 4 Page(s): 190 - 190
01/01/2004 Authors: Koehn B; Ahmed R; Larsen C -
Adhesion molecule expression profiles of rejecting skin allografts.
Volume: 4 Page(s): 561 - 561
01/01/2004 Authors: Jones TR; Adams AB; Hendrix R; Pearson TC; Larsen CP -
Blockade of the CD40-CD154 pathway using a chimeric anti-human CD40 monoclonal antibody synergized with CD28 blockade to prolong islet allograft survival.
Volume: 4 Page(s): 292 - 292
01/01/2004 Authors: Adams AB; Shirasugi N; Jones TR; Strobert E; Durham MM; Hollenbaugh D; Haggerty D; Townsend R; Pearson TC; Larsen CP -
Inability to clear polyoma virus in MHC disparate murine kidney transplant model results in accelerated graft rejection.
Volume: 4 Page(s): 599 - 599
01/01/2004 Authors: Lee EDH; Wang J; Dong Y; Lukacher AE; Newell KA; Pearson TC; Larsen CP -
NK cell alloreactivity is an important mediator of costimulation-blockade-resistant rejection during allogeneic transplantation.
Volume: 4 Page(s): 580 - 580
01/01/2004 Authors: Kean L; Coley S; Adams A; Hamby K; Lee E; Heiss E; Pearson T; Larsen C -
Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.
Blood Volume: 102 Page(s): 4582 - 4593
12/15/2003 Authors: Kean LS; Manci EA; Perry J; Balkan C; Coley S; Holtzclaw D; Adams AB; Larsen CP; Hsu LL; Archer DR -
Heterologous immunity: an overlooked barrier to tolerance.
Immunol Rev Volume: 196 Page(s): 147 - 160
12/01/2003 Authors: Adams AB; Pearson TC; Larsen CP -
Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells.
Am J Transplant Volume: 3 Page(s): 1520 - 1530
12/01/2003 Authors: Jones TR; Adams AB; Shirasugi NJ; Bingaman AW; Durham MM; Pearson TC; Larsen CP -
Intravital microscopy identifies selectins that regulate T cell traffic into allografts.
J Clin Invest Volume: 112 Page(s): 1714 - 1723
12/01/2003 Authors: Jones TR; Shirasugi N; Adams AB; Pearson TC; Larsen CP -
Evidence for heterologous immunity in sickle-mediated allograft rejection.
Volume: 102 Page(s): 112A - 112A
11/16/2003 Authors: Kean L; Hamby K; Perry J; Rees P; Pearson T; Larsen C; Archer D -
Simultaneous pancreas-kidney transplantation utilizing a common arterial conduit: early experience and potential applications.
Am J Transplant Volume: 3 Page(s): 1440 - 1443
11/01/2003 Authors: Tso PL; Cash MP; Pearson TC; Larsen CP; Newell KA -
Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion.
Am J Transplant Volume: 3 Page(s): 1091 - 1098
09/01/2003 Authors: Guo Z; Wang J; Dong Y; Adams AB; Shirasugi N; Kim O; Hart J; Newton-West M; Pearson TC; Larsen CP -
Targeting the ICOS-B7h costimulatory pathway synergizes with rapamycin to regulate alloresponses in islet transplantation
Volume: 76 Page(s): S51 - S51
08/27/2003 Authors: Nanji SA; Hancock WW; Anderson CC; Adams AB; Luo B; Wong LQ; Coyle AJ; Larsen CP; Shapiro J -
Combined CD40/CD28 blockade synergizes to promote islet allograft survival in a nonhuman primate model
Volume: 76 Page(s): S31 - S31
08/27/2003 Authors: Adams AB; Shirasugi N; Strobert EA; Cowan SR; Rees PA; Hendrix R; Kenyon NS; Pearson TC; Larsen CP -
Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction.
Am J Transplant Volume: 3 Page(s): 895 - 901
07/01/2003 Authors: Adams AB; Shirasugi N; Jones TR; Williams MA; Durham MM; Ha J; Dong Y; Guo Z; Newell KA; Pearson TC -
Heterologous immunity provides a potent barrier to transplantation tolerance.
J Clin Invest Volume: 111 Page(s): 1887 - 1895
06/01/2003 Authors: Adams AB; Williams MA; Jones TR; Shirasugi N; Durham MM; Kaech SM; Wherry EJ; Onami T; Lanier JG; Kokko KE -
Induction of operational tolerance to discordant dopaminergic porcine xenografts.
Transplantation Volume: 75 Page(s): 1448 - 1454
05/15/2003 Authors: Larsson LC; Corbascio M; Pearson TC; Larsen CP; Ekberg H; Widner H -
Role of 4-1BB in allograft rejection mediated by CD8+ T cells.
Am J Transplant Volume: 3 Page(s): 543 - 551
05/01/2003 Authors: Wang J; Guo Z; Dong Y; Kim O; Hart J; Adams A; Larsen CP; Mittler RS; Newell KA -
Islet transplantation, stem cells, and transfusion medicine.
Transfus Med Rev Volume: 17 Page(s): 95 - 109
04/01/2003 Authors: Lgdberg L; Sgan SL; Larsen CP; Hillyer CD -
Primary and secondary immunocompetence in mixed allogeneic chimeras.
J Immunol Volume: 170 Page(s): 2382 - 2389
03/01/2003 Authors: Williams MA; Adams AB; Walsh MB; Shirasugi N; Onami TM; Pearson TC; Ahmed R; Larsen CP -
A critical role for 4-1BB in allograft rejection mediated by CD8(+) T cells
Volume: 83 Page(s): 124A - 124A
01/01/2003 Authors: Kim OS; Guo Z; Wang J; Hart J; Larsen CP; Newell KA -
Critical role for 4-1BB in-allograft rejection mediated by CD8(+) T cells
Volume: 16 Page(s): 124A - 124A
01/01/2003 Authors: Kim OS; Guo Z; Wang J; Hart J; Larsen CP; Newell KA -
Targeting the ICOS-B7H costeaulatory pathway synergizes with rapamycin to regulate alloresponses in islet transplantation
Volume: 12 Page(s): 144 - 144
01/01/2003 Authors: Nanji SA; Hancock WW; Anderson CC; Adams AB; Luo B; Schur CD; Wong LQ; Coyle AJ; Larsen CP; Shapiro AMJ -
Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.
J Immunol Volume: 169 Page(s): 5387 - 5391
11/15/2002 Authors: Williams MA; Onami TM; Adams AB; Durham MM; Pearson TC; Ahmed R; Larsen CP -
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation Volume: 74 Page(s): 933 - 940
10/15/2002 Authors: Pearson TC; Trambley J; Odom K; Anderson DC; Cowan S; Bray R; Lin A; Hollenbaugh D; Aruffo A; Siadak AW -
SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways.
Mol Med Volume: 8 Page(s): 551 - 558
09/01/2002 Authors: Arbiser JL; Bingaman A; Durham M; Cowan S; Cohen C; Zarnegar E; Varma V; Larsen CP -
Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens.
J Immunol Volume: 169 Page(s): 2677 - 2684
09/01/2002 Authors: Shirasugi N; Adams AB; Durham MM; Lukacher AE; Xu H; Rees P; Cowan SR; Williams MA; Pearson TC; Larsen CP -
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.
Transplantation Volume: 74 Page(s): 35 - 41
07/15/2002 Authors: Corbascio M; Mahanty H; Osterholm C; Qi Z; Pearson TC; Larsen CP; Freise CE; Ekberg H -
Dynamic regulation of T cell immunity by CD43.
J Immunol Volume: 168 Page(s): 6022 - 6031
06/15/2002 Authors: Onami TM; Harrington LE; Williams MA; Galvan M; Larsen CP; Pearson TC; Manjunath N; Baum LG; Pearce BD; Ahmed R -
Long-term chimerism from T-cell depleted allogeneic one marrow transplantation with low-dose busulfan and CD40-CD154 blockade
EXPERIMENTAL HEMATOLOGY Volume: 30 Page(s): 118 - 118
06/01/2002 Authors: Li J; Gorechald J; Larsen C; Waller E -
Transplantation tolerance: Emerging strategies and potential consequences on protective immunity.
CLINICAL IMMUNOLOGY Volume: 103 Page(s): S93 - S94
06/01/2002 Authors: Larsen CP -
CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely.
Transpl Immunol Volume: 10 Page(s): 55 - 61
06/01/2002 Authors: Corbascio M; Ekstrand H; Osterholm C; Qi Z; Simanaitis M; Larsen CP; Pearson TC; Riesbeck K; Ekberg H -
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.
Blood Volume: 99 Page(s): 1840 - 1849
03/01/2002 Authors: Kean LS; Durham MM; Adams AB; Hsu LL; Perry JR; Dillehay D; Pearson TC; Waller EK; Larsen CP; Archer DR -
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.
Diabetes Volume: 51 Page(s): 265 - 270
02/01/2002 Authors: Adams AB; Shirasugi N; Durham MM; Strobert E; Anderson D; Rees P; Cowan S; Xu H; Blinder Y; Cheung M -
The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts.
J Immunol Volume: 168 Page(s): 1123 - 1130
02/01/2002 Authors: Jones TR; Ha J; Williams MA; Adams AB; Durham MM; Rees PA; Cowan SR; Pearson TC; Larsen CP -
CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice.
Transplantation Volume: 73 Page(s): 293 - 297
01/27/2002 Authors: Malm H; Corbascio M; Osterholm C; Cowan S; Larsen CP; Pearson TC; Ekberg H -
The role of TNF receptor and TNF superfamily molecules in organ transplantation.
Am J Transplant Volume: 2 Page(s): 12 - 18
01/01/2002 Authors: Adams AB; Larsen CP; Pearson TC; Newell KA -
Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L.
Xenotransplantation Volume: 9 Page(s): 68 - 76
01/01/2002 Authors: Larsson LC; Corbascio M; Widner H; Pearson TC; Larsen CP; Ekberg H -
Progressive correction of murine Sickle cell disease with increasing levels of red cell chimerism after allogeneic bone marrow transplantation.
BLOOD Volume: 98 Page(s): 172A - 172A
11/16/2001 Authors: Kean L; Durham M; Adams A; Hsu LL; Pearson T; Larsen C; Archer DR -
A cure for murine sickle cell disease (SCD) through stable mixed chimerism and tolerance induction after non-myeloablative conditioning and MHC-mismatched bone marrow transplantation.
BLOOD Volume: 98 Page(s): 736A - 736A
11/16/2001 Authors: Kean L; Durham M; Adams A; Hsu LL; Waller E; Dillehay D; Pearson T; Larsen C; Archer DR -
Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.
J Immunol Volume: 167 Page(s): 5565 - 5573
11/15/2001 Authors: Suresh M; Whitmire JK; Harrington LE; Larsen CP; Pearson TC; Altman JD; Ahmed R -
Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.
J Immunol Volume: 167 Page(s): 4987 - 4995
11/01/2001 Authors: Williams MA; Tan JT; Adams AB; Durham MM; Shirasugi N; Whitmire JK; Harrington LE; Ahmed R; Pearson TC; Larsen CP -
Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4+ T cells in vivo.
Transplantation Volume: 72 Page(s): 1286 - 1292
10/15/2001 Authors: Bingaman AW; Ha J; Durham MM; Waitze SY; Tucker-Burden C; Cowan SR; Pearson TC; Larsen CP -
Aggressive skin allograft rejection in CD28-/- mice independent of the CD40/CD40L costimulatory pathway.
Transpl Immunol Volume: 9 Page(s): 13 - 17
10/01/2001 Authors: Ha J; Bingaman AW; Durham MM; Pearson TC; Larsen CP -
Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology.
Transplantation Volume: 72 Page(s): 948 - 953
09/15/2001 Authors: Akalin E; Hendrix RC; Polavarapu RG; Pearson TC; Neylan JF; Larsen CP; Lakkis FG -
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
J Immunol Volume: 167 Page(s): 1103 - 1111
07/15/2001 Authors: Adams AB; Durham MM; Kean L; Shirasugi N; Ha J; Williams MA; Rees PA; Cheung MC; Mittelstaedt S; Bingaman AW -
Conventional immunosuppression and co-stimulation blockade.
Philos Trans R Soc Lond B Biol Sci Volume: 356 Page(s): 703 - 705
05/29/2001 Authors: Adams AB; Pearson TC; Larsen CP -
CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Transplantation Volume: 71 Page(s): 1351 - 1354
05/15/2001 Authors: Guo Z; Meng L; Kim O; Wang J; Hart J; He G; Alegre ML; Thistlethwaite JR; Pearson TC; Larsen CP -
Innate immune responses to transplants: a significant variable with cadaver donors.
Immunity Volume: 14 Page(s): 369 - 376
04/01/2001 Authors: Baldwin WM; Larsen CP; Fairchild RL -
Expression of the melanocortin 5 receptor on rat lymphocytes.
Biochem Biophys Res Commun Volume: 281 Page(s): 1086 - 1092
03/01/2001 Authors: Akbulut S; Byersdorfer CA; Larsen CP; Zimmer SL; Humphreys TD; Clarke BL -
Defective fasL reveals immunregulation after costimulation blockade.
Transplantation Volume: 71 Page(s): 496 - 497
02/27/2001 Authors: Cobbold S -
FasL is important in costimulation blockade-resistant skin graft rejection.
Transplantation Volume: 71 Page(s): 537 - 543
02/27/2001 Authors: Trambley J; Lin A; Elwood E; Bingaman AW; Lakkis F; Corbascio M; Pearson TC; Larsen CP -
Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection.
Transplant Proc Volume: 33 Page(s): 418 - 420
01/01/2001 Authors: Meng L; Guo Z; Kim O; He G; Hart J; Szot GL; Wang J; Pearson TC; Larsen CP; Newell KA -
Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.
J Immunol Volume: 165 Page(s): 6849 - 6857
12/15/2000 Authors: Williams MA; Trambley J; Ha J; Adams AB; Durham MM; Rees P; Cowan SR; Pearson TC; Larsen CP -
The role of CD40L in T cell-dependent nitric oxide production by murine macrophages.
Transpl Immunol Volume: 8 Page(s): 195 - 202
11/01/2000 Authors: Bingaman AW; Pearson TC; Larsen CP -
Analysis of a single-center experience with mycophenolate mofetil based immunosuppression in renal transplantation.
Clin Transplant Volume: 14 Page(s): 413 - 420
08/01/2000 Authors: Triemer HL; Pearson TC; Odom KL; Larsen CP -
Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.
Transplantation Volume: 70 Page(s): 175 - 183
07/15/2000 Authors: Tan JT; Ha J; Cho HR; Tucker-Burden C; Hendrix RC; Mittler RS; Pearson TC; Larsen CP -
Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning.
J Immunol Volume: 165 Page(s): 1 - 4
07/01/2000 Authors: Durham MM; Bingaman AW; Adams AB; Ha J; Waitze SY; Pearson TC; Larsen CP -
Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism without cytoreductive conditioning.
Transplantation Volume: 69 Page(s): 2491 - 2496
06/27/2000 Authors: Bingaman AW; Waitze SY; Alexander DZ; Cho HR; Lin A; Tucker-Burden C; Cowan SR; Pearson TC; Larsen CP -
Prolongation of renal allograft survival by a chimeric anti-human CD40 monoclonal antibody in nonhuman primates.
TRANSPLANTATION Volume: 69 Page(s): S123 - S123
04/27/2000 Authors: Larsen CP; Odom K; Hollenbaugh D; Bray R; Hennigar R; Pearsen TC -
Role of CD40L in the initiation, amplification, and effector phase of alloimmune responses.
TRANSPLANTATION Volume: 69 Page(s): S131 - S131
04/27/2000 Authors: Ha J; Bingaman AW; Durham MM; Adams AB; Pearson TC; Larsen CP -
Blockade of the CD40 costimulatory pathway fails to prevent CD8 T cell-mediated rejection of intestinal allografts.
TRANSPLANTATION Volume: 69 Page(s): S416 - S416
04/27/2000 Authors: Meng LZ; Guo Z; Kim O; He G; Hart J; Szot GL; Wang J; Larsen CP; Newell KA -
Fas ligand plays a crucial role in costimulation blockade resistant rejection.
TRANSPLANTATION Volume: 69 Page(s): S398 - S398
04/27/2000 Authors: Trambley JF; Lin A; Elwood ET; Lakkis FG; Pearson TC; Larsen CP -
The expression and function of the 4-1BB in alloimmune responses.
TRANSPLANTATION Volume: 69 Page(s): S130 - S130
04/27/2000 Authors: Tan JT; Ha JW; Tucker-Burden C; Hendrix RC; Cho HR; Mittler RS; Pearson TC; Larsen CP -
Prolongation of renal allograft survival with blockade of the CD28 pathway using a novel mutant CTLA4-Ig fusion protein in non-human primates.
TRANSPLANTATION Volume: 69 Page(s): S123 - S123
04/27/2000 Authors: Pearson TC; Lin A; Odom K; Cowan S; Peach R; Haggerty D; Larsen CP -
Administration of repeated doses of anti-CD40L and donor bone marrow leads to hematopoietic chimerism and donor specific tolerance without cytoreductive conditioning.
TRANSPLANTATION Volume: 69 Page(s): S240 - S240
04/27/2000 Authors: Durham MM; Bingaman AW; Adams AB; Ha JW; Waitze SY; Pearson TC; Larsen CP -
Hematopoietic chimerism in the presence of CD40 and CD28 blockade leads to peripheral deletion of donor reactive T cells and development of donor specific transplantation tolerance.
TRANSPLANTATION Volume: 69 Page(s): S240 - S240
04/27/2000 Authors: Bingaman AW; Durham MM; Adams AB; Ha JW; Pearson TC; Larsen CP -
CTLA4-Ig and MRI synergize with microencapsulation to prolong survival of adult porcine islet xenografts in diabetic NOD mice.
FASEB JOURNAL Volume: 14 Page(s): A1070 - A1070
04/20/2000 Authors: Safley SA; Kapp JA; Larsen CP; Pearson TC; Hering BJ; Weber CJ -
Vigorous allograft rejection in the absence of danger.
J Immunol Volume: 164 Page(s): 3065 - 3071
03/15/2000 Authors: Bingaman AW; Ha J; Waitze SY; Durham MM; Cho HR; Tucker-Burden C; Hendrix R; Cowan SR; Pearson TC; Larsen CP -
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
J Immunol Volume: 164 Page(s): 2320 - 2325
03/01/2000 Authors: Tan JT; Whitmire JK; Murali-Krishna K; Ahmed R; Altman JD; Mittler RS; Sette A; Pearson TC; Larsen CP -
Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.
J Clin Invest Volume: 104 Page(s): 1715 - 1722
12/01/1999 Authors: Trambley J; Bingaman AW; Lin A; Elwood ET; Waitze SY; Ha J; Durham MM; Corbascio M; Cowan SR; Pearson TC -
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
J Immunol Volume: 163 Page(s): 4859 - 4868
11/01/1999 Authors: Tan JT; Whitmire JK; Ahmed R; Pearson TC; Larsen CP -
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
J Immunol Volume: 163 Page(s): 3194 - 3201
09/15/1999 Authors: Whitmire JK; Flavell RA; Grewal IS; Larsen CP; Pearson TC; Ahmed R -
Analysis of the CD40 and CD28 T cell costimulatory pathways in allograft rejection mediated by CD4 and CD8 T cell subsets
TRANSPLANTATION Volume: 67 Page(s): S262 - S262
04/15/1999 Authors: Bingaman AW; Ha J; Waitze SR; Tucker-Burden C; Pearson TC; Larsen CP -
Asialo GM1+CD8+cells play an important role in costimulatory blockade resistant rejection
TRANSPLANTATION Volume: 67 Page(s): S113 - S113
04/15/1999 Authors: Trambley J; Bingaman A; Lin A; Larsen C; Pearson T -
Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism and shapes the T cell repertoire without cytoreductive conditioning
TRANSPLANTATION Volume: 67 Page(s): S34 - S34
04/15/1999 Authors: Bingaman AW; Waitze SR; Alexander DZ; Cho HR; Tucker-Burden C; Cowan SR; Pearson TC; Larsen CP -
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
J Immunol Volume: 161 Page(s): 5331 - 5337
11/15/1998 Authors: Niimi M; Pearson TC; Larsen CP; Alexander DZ; Hollenbaugh D; Aruffo A; Linsley PS; Thomas E; Campbell K; Fanslow WC -
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation Volume: 65 Page(s): 1422 - 1428
06/15/1998 Authors: Elwood ET; Larsen CP; Cho HR; Corbascio M; Ritchie SC; Alexander DZ; Tucker-Burden C; Linsley PS; Aruffo A; Hollenbaugh D -
IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.
J Immunol Volume: 160 Page(s): 2059 - 2064
03/01/1998 Authors: Konieczny BT; Dai Z; Elwood ET; Saleem S; Linsley PS; Baddoura FK; Larsen CP; Pearson TC; Lakkis FG -
Great expectations.
Reflections Volume: 24 Page(s): 14 - 16
01/01/1998 Authors: Williams PD; Williams AR; Lopez M; Piamjariyakul U; Soetjiningsih; Tayko NP -
The CD40 pathway in allograft rejection, acceptance, and tolerance.
Curr Opin Immunol Volume: 9 Page(s): 641 - 647
10/01/1997 Authors: Larsen CP; Pearson TC -
Interferon-gamma (IFN gamma) is required for long-term allograft survival in mice treated with costimulation blockade.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A3071 - A3071
09/01/1997 Authors: Konieczny BT; Dai ZH; Elwood ET; Larsen CP; Pearson TC; Linsley PS; Lakkis FG -
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
J Exp Med Volume: 186 Page(s): 47 - 55
07/07/1997 Authors: Shuford WW; Klussman K; Tritchler DD; Loo DT; Chalupny J; Siadak AW; Brown TJ; Emswiler J; Raecho H; Larsen CP -
Drainage of the exocrine pancreas in clinical transplantation: comparison of bladder versus enteric drainage in a consecutive series.
Clin Transplant Volume: 11 Page(s): 201 - 205
06/01/1997 Authors: Pearson TC; Santamaria PJ; Routenberg KL; O'Brien DP; Whelchel JD; Neylan JF; Larsen CP -
Analysis of the B7 costimulatory pathway in allograft rejection.
Transplantation Volume: 63 Page(s): 1463 - 1469
05/27/1997 Authors: Pearson TC; Alexander DZ; Corbascio M; Hendrix R; Ritchie SC; Linsley PS; Faherty D; Larsen CP -
Microchimerism and rejection in clinical transplantation.
Lancet Volume: 349 Page(s): 1358 - 1360
05/10/1997 Authors: Elwood ET; Larsen CP; Maurer DH; Routenberg KL; Neylan JF; Whelchel JD; O'Brien DP; Pearson TC -
Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
J Immunol Volume: 158 Page(s): 2443 - 2448
03/01/1997 Authors: Lakkis FG; Konieczny BT; Saleem S; Baddoura FK; Linsley PS; Alexander DZ; Lowry RP; Pearson TC; Larsen CP -
CTLA4Ig induces longterm cardiac allograft survival in the absence of interleukin-4.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 7 Page(s): A3204 - A3204
09/01/1996 Authors: Lakkis FG; Konieczny BT; Lowry RP; Linsley PS; Alexander DZ; Pearson TC; Larsen CP -
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature Volume: 381 Page(s): 434 - 438
05/30/1996 Authors: Larsen CP; Elwood ET; Alexander DZ; Ritchie SC; Hendrix R; Tucker-Burden C; Cho HR; Aruffo A; Hollenbaugh D; Linsley PS -
CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism.
Transplantation Volume: 61 Page(s): 997 - 1004
04/15/1996 Authors: Pearson TC; Alexander DZ; Hendrix R; Elwood ET; Linsley PS; Winn KJ; Larsen CP -
CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice.
Transplant Proc Volume: 28 Page(s): 821 - 823
04/01/1996 Authors: Weber CJ; Hagler MK; Chryssochoos JT; Larsen CP; Pearson TC; Jensen P; Kapp JA; Linsley PS -
Analysis of effector mechanisms in murine cardiac allograft rejection.
Transpl Immunol Volume: 4 Page(s): 46 - 48
03/01/1996 Authors: Alexander DZ; Pearson TC; Hendrix R; Ritchie SC; Larsen CP -
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation Volume: 61 Page(s): 4 - 9
01/15/1996 Authors: Larsen CP; Alexander DZ; Hollenbaugh D; Elwood ET; Ritchie SC; Aruffo A; Hendrix R; Pearson TC -
Microchimerism and allograft rejection in clinical transplantation.
HUMAN IMMUNOLOGY Volume: 49 Page(s): 91 - 91
01/01/1996 Authors: Elwood E; Maurer D; Larsen C; Pearson T -
Evolving strategies in immunosuppressive therapy: the Emory experience.
Clin Transpl Page(s): 249 - 255
01/01/1996 Authors: Whelchel JD; Hymes LC; Hochgelerent EL; Larsen CP; Lowance DC; O'Brien DP; Neylan JF; Pearson TC; Warshaw BL -
Identification of donor-derived dendritic cell progenitors in bone marrow of spontaneously tolerant liver allograft recipients.
Transplantation Volume: 60 Page(s): 1555 - 1559
12/27/1995 Authors: Thomson AW; Lu L; Wan Y; Qian S; Larsen CP; Starzl TE -
Delayed urinary bladder leak after combined kidney-pancreas transplantation. Association with penile prosthesis implantation.
Transplantation Volume: 60 Page(s): 624 - 626
09/27/1995 Authors: Pearson TC; Futral AA; Routenberg KL; O'Brien DP; Whelchel JD; Neylan JF; Larsen CP -
Fas-mediated cytotoxicity. An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses?
Transplantation Volume: 60 Page(s): 221 - 224
08/15/1995 Authors: Larsen CP; Alexander DZ; Hendrix R; Ritchie SC; Pearson TC -
Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.
J Exp Med Volume: 181 Page(s): 2237 - 2247
06/01/1995 Authors: Roake JA; Rao AS; Morris PJ; Larsen CP; Hankins DF; Austyn JM -
Systemic lipopolysaccharide recruits dendritic cell progenitors to nonlymphoid tissues.
Transplantation Volume: 59 Page(s): 1319 - 1324
05/15/1995 Authors: Roake JA; Rao AS; Morris PJ; Larsen CP; Hankins DF; Austyn JM -
ANALYSIS OF THE MECHANISMS OF CTLA4-IG PLUS BONE-MARROW INDUCED TRANSPLANTATION TOLERANCE
FASEB JOURNAL Volume: 9 Page(s): A783 - A783
03/10/1995 Authors: ALEXANDER DZ; PEARSON TC; RITCHIE SC; HENDRIX R; GERBER DA; LINSLEY PS; LARSEN CP -
CTLA4-IG PLUS BONE-MARROW INDUCES TRANSPLANTATION TOLERANCE IN THE MURINE MODEL
JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 30 - 30
03/10/1995 Authors: PEARSON TC; ALEXANDER DZ; HENDRIX R; RITCHIE SC; LINSLEY PS; LARSEN CP -
ANALYSIS OF THE MECHANISMS OF CTLA4-IG PLUS BONE-MARROW INDUCED TRANSPLANTATION TOLERANCE
JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 23 - 23
03/10/1995 Authors: ALEXANDER DZ; PEARSON TC; RITCHIE SC; HENDRIX R; GERBER DA; LINSLEY PS; LARSEN CP -
REGULATION OF IMMUNOSTIMULATORY FUNCTION AND B7 MOLECULE EXPRESSION ON MURINE DC
JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 21 - 21
03/10/1995 Authors: RITCHIE SC; PEARSON TC; GERBER DA; HENDRIX R; ALEXANDER DZ; LINSLEY PS; LARSEN CP -
AN ANALYSIS OF THE ROLE OF FAS AND FAS LIGAND IN MURINE CARDIAC ALLOGRAFTS
FASEB JOURNAL Volume: 9 Page(s): A502 - A502
03/09/1995 Authors: LARSEN CP; HENDRIX AR; RITCHIE SC; PEARSON TC -
Interleukin-10 eliminates anti-CD3 monoclonal antibody-induced mortality and prolongs heart allograft survival in inbred mice.
Volume: 27 Page(s): 392 - 394
02/01/1995 Authors: Lowry RP; Konieczny B; Alexander D; Larsen C; Pearson T; Smith S; Narula S -
Prolongation of murine cardiac allograft survival by microspheres containing TNF alpha and IL1-beta neutralizing antibodies.
J Drug Target Volume: 3 Page(s): 311 - 315
01/01/1995 Authors: Gerber DA; Oettinger CW; D'Souza M; Milton GV; Larsen CP; Pearson TC -
A COMPARISON OF IN-VITRO CYTOKINE INDUCTION BY OKT3, ATGAM, AND ANTITHYMOCYTE-SERUM (ATS)
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 986 - 986
09/01/1994 Authors: OETTINGER CW; MILLER HC; DSOUSA MJ; MILLERMESSANA MA; JOHNSON HK; OLIVER JC -
MICROCAPSULES CONTAINING TNF-ALPHA AND IL-BETA NEUTRALIZING ANTIBODIES TARGETED TO MACROPHAGES SUPPRESS OKT3 AND ANTITHYMOCYTE-SERUM (ATS) STIMULATED CYTOKINE RELEASE
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 986 - 986
09/01/1994 Authors: OETTINGER CW; JOHNSON HK; DSOUZA MJ; MILLER HC; MILLERMESSANA MA; OLIVER JC -
DE-NOVO GLOMERULOPATHY IN RENAL-ALLOGRAFT RECIPIENTS WITH HEPATITIS-C OR RECURRENT CMV INFECTION
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 1021 - 1021
09/01/1994 Authors: LOWRY RP; HENNIGAR R; SOMEREN A; PEARSON T; LARSEN C; WHELCHEL J; NEYLAN J -
PROLONGATION OF ALLOGRAFT SURVIVAL USING MACROPHAGE-TARGETED MICROENCAPSULATED TNF-ALPHA AND IL-1-BETA NEUTRALIZING ANTIBODIES
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 986 - 986
09/01/1994 Authors: OETTINGER CW; GERBER DA; OLIVER JC; PEARSON TC; DSOUZA MJ; LARSEN CP -
Transplantation tolerance induced by CTLA4-Ig.
Transplantation Volume: 57 Page(s): 1701 - 1706
06/27/1994 Authors: Pearson TC; Alexander DZ; Winn KJ; Linsley PS; Lowry RP; Larsen CP -
Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
J Immunol Volume: 152 Page(s): 5208 - 5219
06/01/1994 Authors: Larsen CP; Ritchie SC; Hendrix R; Linsley PS; Hathcock KS; Hodes RJ; Lowry RP; Pearson TC -
IL-10 ELIMINATES MORTALITY IN ANTI-CD3 MAB TREATED MICE
FASEB JOURNAL Volume: 8 Page(s): A738 - A738
03/18/1994 Authors: LOWRY RP; KONIECZNY B; ALEXANDER D; LARSEN C; SMITH SR; SIEGEL MI; PEARSON T -
Isolation and characterization of dendritic cells from mouse heart and kidney.
J Immunol Volume: 152 Page(s): 2401 - 2410
03/01/1994 Authors: Austyn JM; Hankins DF; Larsen CP; Morris PJ; Rao AS; Roake JA -
Racial issues in renal transplantation: the Emory University experience.
Clin Transpl Page(s): 253 - 258
01/01/1993 Authors: Whelchel JD; Neylan JF; Frederickson ED; Hochgelerent EL; Hymes LC; Larsen CP; Lowance DC; Lowry RP; O'Brien DP; Warshaw BL -
Cytokine mediators of non-lymphoid dendritic cell migration.
Adv Exp Med Biol Volume: 329 Page(s): 501 - 506
01/01/1993 Authors: Roake JA; Rao AS; Larsen CP; Hankins DF; Morris PJ; Austyn JM -
Isolation of dendritic leukocytes from non-lymphoid organs.
Adv Exp Med Biol Volume: 329 Page(s): 507 - 512
01/01/1993 Authors: Rao AS; Roake JA; Larsen CP; Hankins DF; Morris PJ; Austyn JM -
DONOR LEUKOCYTE MIGRATION FOLLOWING EXTREMITY TRANSPLANTATION IN AN EXPERIMENTAL-MODEL - DISCUSSION
PLASTIC AND RECONSTRUCTIVE SURGERY Volume: 90 Page(s): 1007 - 1008
12/01/1992 Authors: LARSEN CP -
Donor leukocyte migration following extremity transplantation in an experimental model.
Plast Reconstr Surg Volume: 90 Page(s): 999 - 1006
12/01/1992 Authors: Hoffman LA; Codner MA; Shuster BA; Bogossian N; Egozi L; Harper AD; Steinman RM; LaTrenta GS; Shires GT -
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
J Exp Med Volume: 176 Page(s): 1215 - 1220
10/01/1992 Authors: Larsen CP; Ritchie SC; Pearson TC; Linsley PS; Lowry RP -
Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody.
Transplantation Volume: 54 Page(s): 475 - 483
09/01/1992 Authors: Pearson TC; Madsen JC; Larsen CP; Morris PJ; Wood KJ -
MIGRATION AND MATURATION OF NONLYMPHOID DENDRITIC CELLS
Page(s): 75 - 80
01/01/1992 Authors: ROAKE JA; RAO AS; LARSEN CP; AUSTYN JM -
Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.
J Exp Med Volume: 174 Page(s): 493 - 496
08/01/1991 Authors: Dallman MJ; Larsen CP; Morris PJ -
Management of the asymptomatic patient with a stab wound to the chest.
South Med J Volume: 84 Page(s): 591 - 593
05/01/1991 Authors: Brown PF; Larsen CP; Symbas PN -
Cytokine gene expression: analysis using northern blotting, polymerase chain reaction and in situ hybridization.
Immunol Rev Volume: 119 Page(s): 163 - 179
02/01/1991 Authors: Dallman MJ; Montgomery RA; Larsen CP; Wanders A; Wells AF -
Langerhans cells migrate out of skin grafts and cultured skin: a model in which to study the mediators of dendritic leukocyte migration.
Transplant Proc Volume: 23 Page(s): 117 - 119
02/01/1991 Authors: Larsen CP; Austyn JM -
MATURATION, MIGRATION AND FUNCTION OF DENDRITIC LEUKOCYTES AFTER TRANSPLANTATION
Volume: 926 Page(s): 209 - 215
01/01/1991 Authors: AUSTYN JM; LARSEN CP -
Migration and maturation of Langerhans cells in skin transplants and explants.
J Exp Med Volume: 172 Page(s): 1483 - 1493
11/01/1990 Authors: Larsen CP; Steinman RM; Witmer-Pack M; Hankins DF; Morris PJ; Austyn JM -
The role of graft-derived dendritic leukocytes in the rejection of vascularized organ allografts. Recent findings on the migration and function of dendritic leukocytes after transplantation.
Ann Surg Volume: 212 Page(s): 308 - 315
09/01/1990 Authors: Larsen CP; Austyn JM; Morris PJ -
Donor dendritic leukocytes migrate from cardiac allografts into recipients' spleens.
Transplant Proc Volume: 22 Page(s): 1943 - 1944
08/01/1990 Authors: Larsen CP; Morris PJ; Austyn JM -
Failure of mature dendritic cells of the host to migrate from the blood into cardiac or skin allografts.
Transplantation Volume: 50 Page(s): 294 - 301
08/01/1990 Authors: Larsen CP; Barker H; Morris PJ; Austyn JM -
Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
J Exp Med Volume: 171 Page(s): 307 - 314
01/01/1990 Authors: Larsen CP; Morris PJ; Austyn JM -
Migration patterns of dendritic leukocytes. Implications for transplantation.
Transplantation Volume: 49 Page(s): 1 - 7
01/01/1990 Authors: Austyn JM; Larsen CP -
Lymphokine production in allografts--analysis of RNA by northern blotting.
Transplant Proc Volume: 21 Page(s): 296 - 298
02/01/1989 Authors: Dallman MJ; Porter AC; Larsen CP; Morris PJ -
A reappraisal of the Kock continent ileostomy in patients with Crohn's disease.
Surg Gynecol Obstet Volume: 162 Page(s): 105 - 108
02/01/1986 Authors: Bloom RJ; Larsen CP; Watt R; Oberhelman HA