Publications

• MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.
  Leukemia Volume: 38 Page(s): 2685 - 2698
  12/01/2024 Authors: Huelse JM; Bhasin SS; Jacobsen KM; Yim J; Thomas BE; Branella GM; Bakhtiari M; Chimenti ML; Baxter TA; Raikar SS
• Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.
  J Clin Invest Volume: 134
  03/26/2024 Authors: Zhu Y; Banerjee A; Xie P; Ivanov AA; Uddin A; Jiao Q; Chi JJ; Zeng L; Lee JY; Xue Y
• The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity.
  Adv Exp Med Biol Volume: 1465 Page(s): 37 - 53
  01/01/2024 Authors: Townsel A; Jaffe M; Wu Y; Henry CJ; Haynes KA
• Early B-cell development and B-cell maturation are impaired in patients with active hemophagocytic lymphohistiocytosis.
  Volume: 142 Page(s): 1972 - 1984
  12/07/2023 Authors: Shim J; Park S; Venkateswaran S; Kumar D; Prince C; Parihar V; Maples L; Waller EK; Kugathasan S; Briones M
• A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors.
  Volume: 70 Page(s): e30405
  08/01/2023 Authors: Cash T; Jonus HC; Tsvetkova M; Beumer JH; Sadanand A; Lee JY; Henry CJ; Aguilera D; Harvey RD; Goldsmith KC
• Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
  Cancer Res Commun Volume: 3 Page(s): 1248 - 1259
  07/01/2023 Authors: Pillsbury CE; Dougan J; Rabe JL; Fonseca JA; Zhou C; Evans AN; Abukharma H; Ichoku O; Gonzalez-Flamenco G; Park SI
• Sex, aging, immunity and adrenal cancer.
  Nat Aging Volume: 3 Page(s): 764 - 765
  07/01/2023 Authors: Townsel A; Henry CJ
• The 'omics of obesity in B-cell acute lymphoblastic leukemia.
  J Natl Cancer Inst Monogr Volume: 2023 Page(s): 12 - 29
  05/04/2023 Authors: Geitgey DK; Lee M; Cottrill KA; Jaffe M; Pilcher W; Bhasin S; Randall J; Ross AJ; Salemi M; Castillo-Castrejon M
• Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines.
  Biomacromolecules Volume: 24 Page(s): 1164 - 1172
  03/13/2023 Authors: Birnbaum LA; Sullivan EC; Do P; Uricoli B; Raikar SS; Porter CC; Henry CJ; Dreaden EC
• B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12.
  Sci Rep Volume: 12 Page(s): 11870
  07/13/2022 Authors: Hunter R; Imbach KJ; Zhou C; Dougan J; Hamilton JAG; Chen KZ; Do P; Townsel A; Gibson G; Dreaden EC
• Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.
  Nat Commun Volume: 13 Page(s): 1157
  03/03/2022 Authors: Lee M; Hamilton JAG; Talekar GR; Ross AJ; Michael L; Rupji M; Dwivedi B; Raikar SS; Boss J; Scharer CD
• Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
  Front Cell Dev Biol Volume: 10 Page(s): 909557
  01/01/2022 Authors: Lee M; Geitgey DK; Hamilton JAG; Boss JM; Scharer CD; Spangle JM; Haynes KA; Henry CJ
• Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors.
  Exp Hematol Volume: 112-113 Page(s): 24 - 34
  01/01/2022 Authors: Zhou C; Uluisik R; Rowley JW; David C; Jones CL; Scharer CD; Noetzli L; Fisher MH; Kirkpatrick GD; Bark K
• OBESITY ATTENUTATES T-CELL FUNCTION WHICH IMPACTS T-CELL IMMUNOTHERAPIES IN LYMPHOBLASTIC LEUKEMIA
  Volume: 68 Page(s): S5 - S5
  06/01/2021 Authors: Ross A; Ank R; Lee M; Hamilton J; Story J; Raikar S; Do P; Porter C; Henry C
• IL-412 abrogates mechanisms of immune suppression by B-ALL
  Volume: 206
  05/01/2021 Authors: Hunter R; Henry CJ; Porter C
• Adipocyte-secreted Interleukin-9 Promotes Leukemia Development and Chemoresistance to Front-line Chemotherapies
  Volume: 206
  05/01/2021 Authors: Hamilton JAG; Pillsbury CE; Lee M; Henry CJ
• Obese microenvironments attenuate the efficacy of endogenous and CD19-directed CAR T-cells
  Volume: 206
  05/01/2021 Authors: Ank RS; Henry CJ
• Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds.
  Aging Cell Volume: 20 Page(s): e13309
  02/01/2021 Authors: Hamilton JAG; Lee MY; Hunter R; Ank RS; Story JY; Talekar G; Sisroe T; Ballak DB; Fedanov A; Porter CC
• Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.
  Angiogenesis Volume: 24 Page(s): 177 - 190
  02/01/2021 Authors: Pulous FE; Carnevale JC; Al-Yafeai Z; Pearson BH; Hamilton JAG; Henry CJ; Orr AW; Petrich BG
• MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
  JCI Insight Volume: 5
  12/03/2020 Authors: Lee-Sherick AB; Jacobsen KM; Henry CJ; Huey MG; Parker RE; Page LS; Hill AA; Wang X; Frye SV; Earp HS
• Aging and immunotherapies: New horizons for the golden ages.
  Aging Cancer Volume: 1 Page(s): 30 - 44
  12/01/2020 Authors: Hamilton JAG; Henry CJ
• Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML
  Volume: 136
  11/05/2020 Authors: Thomas BE; Perumalla P; Bhasin SS; Sarkar D; Dwivedi B; Park SI; DeRyckere D; Henry CJ; Raikar SS; Porter CC
• Obesity Attenuates T-Cell Function Which Impacts the Efficacy of T-Cell Based Immunotherapies in Acute Lymphoblastic Leukemia
  Volume: 136
  11/05/2020 Authors: Ross A; Lee M; Hamilton J; Ank R; Do P; Story J; Raikar SS; Dreaden E; Porter CC; Henry CJ
• Obesity-Induced Chemoresistance in B-Cell Acute Lymphoblastic Leukemia Cells Is Mediated By Reduced Chemotherapy Uptake and Interleukin-9 Signaling
  Volume: 136
  11/05/2020 Authors: Hamilton JAG; Lee M; Talekar GR; Henry CJ
• Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia.
  ACS Comb Sci Volume: 22 Page(s): 533 - 541
  10/12/2020 Authors: Do P; Perdue LA; Chyong A; Hunter R; Dougan J; Henry CJ; Porter CC; Dreaden EC
• OBESITY IMPAIRS T-CELL FUNCTION WHICH MAY IMPACT THE EFFICACY OF CAR T-CELLS IN PEDIATRIC LEUKEMIA
  Volume: 67 Page(s): S5 - S6
  06/01/2020 Authors: Ross A; Lee M; Hamilton J; Talekar G; Henry C; Raikar S; Story J
• Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity.
  Mol Nutr Food Res Volume: 64 Page(s): e1901166
  06/01/2020 Authors: Sylvetsky AC; Sen S; Merkel P; Dore F; Stern DB; Henry CJ; Cai H; Walter PJ; Crandall KA; Rother KI
• Promoting anti-tumor immunity via bispecific T cell engaging cytokine (biteokine) therapy
  Volume: 204
  05/01/2020 Authors: Do P; Perdue LA; Chyong A; Henry CJ; Porter CC; Dreaden EC
• Innate immune populations contribute to effective immune responses against B lymphoblastic leukemia cells
  Volume: 204
  05/01/2020 Authors: Hunter R; Henry CJ; Porter CC
• Elevated Levels of Interleukin-9 in Obese Microenvironments Promote Leukemia Progression and Chemoresistance in B-Cell Acute Lymphoblastic Leukemia Cells
  Volume: 134
  11/13/2019 Authors: Hamilton JAG; Lee M; Talekar GR; Henry CJ
• IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression.
  Cancer Res Volume: 79 Page(s): 3702 - 3713
  07/15/2019 Authors: Rabe JL; Gardner L; Hunter R; Fonseca JA; Dougan J; Gearheart CM; Leibowitz MS; Lee-Miller C; Baturin D; Fosmire SP
• Adipocyte-secreted proteins induce DNA damage and apoptosis in T-cell acute lymphoblastic leukemia
  Volume: 79
  07/01/2019 Authors: Lee M; Henry CJ
• Calcineurin represses IL-12 secretion in acute lymphoblastic leukemia
  Volume: 79
  07/01/2019 Authors: Hunter R; Fonseca J; Dougan J; Gardner LA; Rabe J; Rupji M; Dwivedi B; Henry CJ; Porter CC
• DELINEATING THE ROLE OF OBESITY IN IMMUNOTHERAPY EFFICACY IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA
  Volume: 66
  06/01/2019 Authors: Ross A; Hamilton J; Lee M; Talekar G; Henry C
• Interleukin-37 improves aging-associated declines in adaptive immunity leading to enhanced suppression of Ph plus leukemia
  Volume: 202
  05/01/2019 Authors: Henry CJ; Eisenmesser E; Dinarello CA; DeGregori J
• MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
  JCI Insight Volume: 3
  11/02/2018 Authors: Lee-Sherick AB; Jacobsen KM; Henry CJ; Huey MG; Parker RE; Page LS; Hill AA; Wang X; Frye SV; Earp HS
• Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer.
  Cancers (Basel) Volume: 10
  09/14/2018 Authors: Wang J; Wang T; Sun Y; Feng Y; Kisseberth WC; Henry CJ; Mok I; Lana SE; Dobbin K; Northrup N
• OLT1177, a -sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
  Proc Natl Acad Sci U S A Volume: 115 Page(s): E1530 - E1539
  02/13/2018 Authors: Marchetti C; Swartzwelter B; Gamboni F; Neff CP; Richter K; Azam T; Carta S; Tengesdal I; Nemkov T; D'Alessandro A
• Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.
  Haematologica Volume: 102 Page(s): 1985 - 1994
  12/01/2017 Authors: Henry CJ; Nemkov T; Cass-Selves M; Bilousova G; Zaberezhnyy V; Higa KC; Serkova NJ; Hansen KC; D'Alessandro A; DeGregori J
• Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
  J Clin Invest Volume: 125 Page(s): 4666 - 4680
  12/01/2015 Authors: Henry CJ; Cass-Selves M; Kim J; Zaberezhnyy V; Aghili L; Daniel AE; Jimenez L; Azam T; McNamee EN; Clambey ET
• Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma.
  BMC Cancer Volume: 15 Page(s): 123
  03/14/2015 Authors: Henry CJ; Sedjo RL; Rozhok A; Salstrom J; Ahnen D; Levin TR; D'Agostino R; Haffner S; DeGregori J; Byers T
• Bcr-Abl expression overcomes aging-associated functional declines in B-Lymphopoiesis leading to increased leukemogenesis
  Volume: 190
  05/01/2013 Authors: Henry C; Marusyk A; Zaberezhnyy V; Casas M; Serkova N; Clambey E; DeGregori J
• Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B.
  Cancer Cell Int Volume: 12 Page(s): 19
  07/04/2012 Authors: Bahmed K; Henry C; Holliday M; Redzic J; Ciobanu M; Zhang F; Weekes C; Sclafani R; Degregori J; Eisenmesser E
• Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?
  Aging (Albany NY) Volume: 3 Page(s): 643 - 656
  06/01/2011 Authors: Henry CJ; Marusyk A; DeGregori J
• Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo.
  Cell Immunol Volume: 268 Page(s): 79 - 86
  01/01/2011 Authors: Mitchell LM; Brzoza-Lewis KL; Henry CJ; Grayson JM; Westcott MM; Hiltbold EM
• Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
  Proc Natl Acad Sci U S A Volume: 107 Page(s): 21713 - 21718
  12/14/2010 Authors: Henry CJ; Marusyk A; Zaberezhnyy V; Adane B; DeGregori J
• Dendritic cells inhibit the progression of Listeria monocytogenes intracellular infection by retaining bacteria in major histocompatibility complex class II-rich phagosomes and by limiting cytosolic growth.
  Infect Immun Volume: 78 Page(s): 2956 - 2965
  07/01/2010 Authors: Westcott MM; Henry CJ; Amis JE; Hiltbold EM
• The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model.
  Cell Immunol Volume: 264 Page(s): 23 - 31
  01/01/2010 Authors: Henry CJ; Grayson JM; Brzoza-Lewis KL; Mitchell LM; Westcott MM; Cook AS; Hiltbold EM
• Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
  Cancer Res Volume: 69 Page(s): 7262 - 7269
  09/15/2009 Authors: Marusyk A; Cass-Selves M; Henry CJ; Zaberezhnyy V; Klawitter J; Christians U; DeGregori J
• H. influenzae and M. catarrhalis trigger a potent immune response through activation of dendritic cells
  JOURNAL OF IMMUNOLOGY Volume: 182
  04/01/2009 Authors: Dew KE; Henry CJ; Mitchell LM; Hiltbolt EM; Swords WE
• IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.
  J Immunol Volume: 181 Page(s): 8576 - 8584
  12/15/2008 Authors: Henry CJ; Ornelles DA; Mitchell LM; Brzoza-Lewis KL; Hiltbold EM
• Dendritic Cell Produced IL-12 Augments CD8+T cell Activation through the Production of the Chemokines CCL1 and CCL17
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Henry CJ; Grayson JM; Ornelles DA; Brzoza KL; Hiltbold EM
• Differential susceptibility of bone marrow-derived dendritic cells and macrophages to productive infection with Listeria monocytogenes.
  Cell Microbiol Volume: 9 Page(s): 1397 - 1411
  06/01/2007 Authors: Westcott MM; Henry CJ; Cook AS; Grant KW; Hiltbold EM
• IL-12/23 Signals Delivered by Dendritic Cells Predominantly Within the First 48 Hours of T cell Priming Dictates the Functional Capacity of CTLs
  JOURNAL OF IMMUNOLOGY Volume: 178
  04/01/2007 Authors: Henry CJ; Grayson JM; Westcott MM; Brzoza KL; Hiltbold EM
• IL-12 exerts its effects during the first 48 hours of T cell priming leading to stable conjugate formation and robust INF-[gamma] production
  Volume: 176 Page(s): S13 - S14
  04/01/2006 Authors: Henry CJ; Hiltbold E