Cynthia Giver PhD

Department of Hematology and Medical Oncology
Associate Professor

(404) 778-5806
cgiver@emory.edu

Academic Appointment

Associate Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine

Education

Degrees

PhD from University of California
BA from University of California

Research

Focus

Research is focused on the pre-clinical development of cancer immunotherapy strategies for recipients of bone marrow transplantation. The goal is reduction of the detrimental graft- versushost disease (GvHD) activity of donor T-cells, while retaining beneficial graft-versus-leukemia (GvL), anti-viral, and graft facilitating aspects. One area of particular interest is modification of the donor dendritic cell content in the graft to modulate GvHD and GvL activities.

Publications

Donor plasmacytoid dendritic cells regulate GVHD and GVL activities of donor T cells in allogeneic hematopoietic stem cell transplantation
Volume: 57 Page(s): 44 - 44
11/01/2022 Authors: Das PK; Passang T; Zhu J; Wang Y; Li J; Nagy T; Gandhi K; Giver C; Ravindranathan S; Li J
Donor plasmacytoid dendritic cells limit graft-versus-host disease through vasoactive intestinal polypeptide expression.
Blood Volume: 140 Page(s): 1431 - 1447
09/22/2022 Authors: Zhu J; Wang Y; Li J; Das PK; Zhang H; Passang T; Li JM; Nagy T; Gandhi K; Ravindranathan S
Safety of autologous freshly expanded mesenchymal stromal cells for the treatment of graft-versus-host disease.
Front Immunol Volume: 13 Page(s): 959658
01/01/2022 Authors: Stenger E; Giver CR; Langston A; Kota D; Das PK; Chinnadurai R; Galipeau J; Waller EK; Qayed M
Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
Proc Natl Acad Sci U S A Volume: 118
03/16/2021 Authors: Ramesha S; Rayaprolu S; Bowen CA; Giver CR; Bitarafan S; Nguyen HM; Gao T; Chen MJ; Nwabueze N; Dammer EB
Kv1.3 Channel Expressing Brain Myeloid Cells are a Unique Pro-Inflammatory Subset of Microglia Which Can Be Modulated by Kv1.3 Blockers in Alzheimer's Pathology
Volume: 88 Page(s): S109 - S110
10/01/2020 Authors: Ramesha S; Gao T; Giver C; Rayaprolu S; Nwabueze N; Engstorm A; Xiao H; Pennati A; Katz D; Waller EK
Antiviral Immune Monitoring and Support in Allogeneic Stem Cell Transplantation.
Biol Blood Marrow Transplant Volume: 26 Page(s): e92 - e93
05/01/2020 Authors: Giver CR
Transplanted Vasoactive Intestinal Peptide-Secreting Donor Plasmacytoid Dendritic Cells Migrate to Lymphoid Organs and GvHD Target Organs
Volume: 134
11/13/2019 Authors: Zhu J; Wang Y; Li J; Li Y; Antonova AU; Giver CR; Li J; Wang S; Waller EK
Kinetics of immune cell reconstitution predict survival in allogeneic bone marrow and G-CSF-mobilized stem cell transplantation.
Blood Adv Volume: 3 Page(s): 2250 - 2263
08/13/2019 Authors: Waller EK; Logan BR; Fei M; Lee SJ; Confer D; Howard A; Chandrakasan S; Anasetti C; Fernando SM; Giver CR
Graft plasmacytoid dendritic cells improve thymic function in allogeneic hematopoietic cell transplantation
Volume: 202
05/01/2019 Authors: Zhu J; Wang Y; Antonova AU; Li Y; Giver CR; Hassan M; Waller EK
Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease.
Blood Volume: 132 Page(s): 2506 - 2519
12/06/2018 Authors: Swimm A; Giver CR; DeFilipp Z; Rangaraju S; Sharma A; Ulezko Antonova A; Sonowal R; Capaldo C; Powell D; Qayed M
A Prospective Trial of Extracorporeal Photopheresis for Chronic Graft-versus-Host Disease Reveals Significant Disease Response and No Association with Frequency of Regulatory T Cells.
Biol Blood Marrow Transplant Volume: 24 Page(s): 2373 - 2380
12/01/2018 Authors: Gandelman JS; Song DJ; Chen H; Engelhardt BG; Chen Y-B; Clark WB; Giver CR; Waller EK; Jung DK; Jagasia M
Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.
Biol Blood Marrow Transplant Volume: 24 Page(s): 973 - 982
05/01/2018 Authors: Hosoba S; Waller EK; Shenvi N; Graiser M; Easley KA; Al-Kadhimi Z; Andoh A; Antun AG; Barclay S; Josephson CD
Regulatory cells may not be the answer: A prospective study of ECP in cGVHD
Volume: 138 Page(s): S66 - S66
05/01/2018 Authors: Gandelman JS; Song D; Chen H; Engelhardt B; Chen Y; Clark W; Giver C; Waller E; Jagasia M
A Prospective Trial of Extracorporeal Photopheresis (ECP) in the Modern Transplant Era Reveals Response and Decreased Steroid Doses for Patients with Chronic Graft-Versus-Host Disease
Volume: 24 Page(s): S180 - S181
03/01/2018 Authors: Gandelman JS; Song DJ; Chen H; Chen Y-B; Clark WB; Engelhardt BG; Giver CR; Waller EK; Jagasia M
High Completion Rate of ECP Treatment in Patients with Chronic Graft-Versus-Host Disease Despite Unique Barriers: Lessons Learned From a Prospective Multicenter Trial
Volume: 24 Page(s): S268 - S269
03/01/2018 Authors: Song DJ; Gandelman JS; Chen Y-B; Clark WB; Engelhardt BG; Giver CR; Waller EK; Jagasia M
Day 100 Levels of Blood Immune Cells Are Prognostic Biomarkers for Allogeneic Hematopoietic Stem Cell Transplant Outcomes: Results from BMT CTN 0201
Volume: 130
12/07/2017 Authors: Fernando SM; Logan BR; Fei M; Lee SJ; Confer D; Howard A; Chandrakasan S; Giver CR; Anasetti C; Waller EK
Efficacy of Early Post-Transplant Vaccination Using a Prime and Boost Strategy Is Independent of a Prior History of GvHD: Results from BMT CTN 0201
Volume: 130
12/07/2017 Authors: Waller EK; Logan BR; Fei M; Howard A; Wingard JR; Anasetti C; Giver CR
Hierarchical Differences in Defensin Gene Expression in Plasmacytoid Dendritic Cells and Progenitor Cells from Five Different Hematopoietic Stem Cell Transplant Graft Types
Volume: 130
12/07/2017 Authors: Giver CR; Mahar EA; Hosoba S; Kowalski J; Seby S; Zhang XA; Devine SM; Waller EK
Dose dependent association of early red blood cell transfusion with increased risk of graft versus host disease and worse survival after allogeneic hematopoietic stem cell transplantation
Volume: 52 Page(s): S207 - S208
07/01/2017 Authors: Waller EK; Hosoba S; Al-Kadhimi Z; Andoh A; Antun AG; Barclay S; Easley KA; Josephson CD; Khoury HJ; Koff JL
Modulation of Immune Checkpoints and Graft-versus-Leukemia in Allogeneic Transplants by Antagonizing Vasoactive Intestinal Peptide Signaling.
Cancer Res Volume: 76 Page(s): 6802 - 6815
12/01/2016 Authors: Li J-M; Petersen CT; Li J-X; Panjwani R; Chandra DJ; Giver CR; Blazar BR; Waller EK
Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.
Blood Volume: 128 Page(s): 2568 - 2579
11/24/2016 Authors: Furlan SN; Watkins B; Tkachev V; Cooley S; Panoskaltsis-Mortari A; Betz K; Brown M; Hunt DJ; Schell JB; Zeleski K
Response to extracorporeal photopheresis in chronic graft versus host disease correlates with levels of IL-10 producing regulatory B cells
Volume: 196
05/01/2016 Authors: Chandra DJ; Hosoba S; Giver C; Waller EK
Lateral Gene Transfer Contributing to Leukemogenesis
Volume: 126
12/03/2015 Authors: Lee JH; Giver CR; Rangaraju S; Waller EK
Blocking VIP Signaling during Allogeneic Bone Marrow Transplantation Separates the Graft Versus Leukemia from Graft Versus Host Disease Activity of Donor CD8 T-Cells
Volume: 126
12/03/2015 Authors: Li J-M; Petersen CT; Li J; Giver CR; Blazar BR; Waller EK
T Cell Activation By Plasmacytoid Dendritic Cells Is Augmented By Inhibition of Vasoactive Intestinal Polypeptide Signaling: Implications for Cellular Immunotherapy
Volume: 126
12/03/2015 Authors: Li J; Panjwani R; Li J-M; Giver CR; Malone M; Waller EK
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Sci Transl Med Volume: 7 Page(s): 315ra191
11/25/2015 Authors: Furlan SN; Watkins B; Tkachev V; Flynn R; Cooley S; Ramakrishnan S; Singh K; Giver C; Hamby K; Stempora L
Plasmacytoid dendritic cells (pDC) from different allograft sources differ in expression of genes that regulate innate and adaptive immunity after allogeneic stem cell transplantation: implications for selection of the source of the stem cell graft
Volume: 50 Page(s): S63 - S64
03/01/2015 Authors: Waller EK; Harris W; Pauly R; Kowalski J; Logan B; Devine S; Rosenthal H; Hassan M; Lin K; Li J
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS Pathog Volume: 11 Page(s): e1004770
03/01/2015 Authors: Napier RJ; Norris BA; Swimm A; Giver CR; Harris WAC; Laval J; Napier BA; Patel G; Crump R; Peng Z
Defining the Primate T Cell Transcriptome during GvHD: New Data Implicating Sonic Hedgehog and Aurora Kinase Pathways in GvHD Pathogenesis and Prevention
Volume: 21 Page(s): S56 - S56
02/01/2015 Authors: Furlan SN; Watkins BK; Mortari A; Blazar BR; Giver C; Waller EK; Kean LS
Dose and Time-Dependent Association of Red Blood Cell Transfusion with Increased Risk of GvHD and Worse Survival after Allogeneic HSCT
Volume: 124
12/06/2014 Authors: Hosoba S; Waller EK; Barclay S; Easley KA; Shenvi N; Roback J; Zimring JC; Giver CR
Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention
Volume: 124
12/06/2014 Authors: Furlan SN; Watkins B; Flynn RP; Ramakrishnan S; Singh K; Giver CR; Hanby K; Stempora L; Garrett AP; Ziegler CGK
Administration of a Tryptophan Metabolite, Indole-3-Carboxaldehyde, Reduces Graft Versus Host Disease Morbidity and Mortality and Enhances Gastrointestinal Barrier Function in a Murine Model of Allogeneic Bone Marrow Transplantation
Volume: 124
12/06/2014 Authors: Waller EK; Giver CR; Rangaraju S; Swimm A; Sharma A; Qayed M; Defilipp Z; Kalman D
CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis.
Blood Volume: 123 Page(s): 1967 - 1969
03/20/2014 Authors: Kaliyaperumal S; Watkins B; Sharma P; Furlan S; Ramakrishnan S; Giver C; Garcia A; Courtney C; Knight H; Strobert E
TARGETING THE ARYL HYDROCARBON RECEPTOR WITH AN ORAL INDOLE DERIVATIVE TO PREVENT GASTROINTESTINAL GVHD.
Volume: 49 Page(s): S20 - S20
03/01/2014 Authors: Waller EK; Giver CA; Rangaraju S; Swimm A; Sharma A; Quayed M; Kalman D
Host bone marrow-derived IL-12 enhances donor T cell engraftment in a mouse model of bone marrow transplantation.
J Hematol Oncol Volume: 7 Page(s): 16
02/28/2014 Authors: Darlak KA; Wang Y; Li J-M; Harris WA; Giver CR; Huang C; Waller EK
CD8-Predominant T Cell Meningitis Accompanies Gvhd in Primates and Is Prevented with Immunoprophylaxis
Volume: 20 Page(s): S270 - S272
02/01/2014 Authors: Kaliyaperumal S; Sharma P; Watkins BK; Furlan SN; Ramakrishnan S; Giver C; Garcia A; Courtney C; Hamby K; Garrett A
Pharmacological Inhibition Of Semi-Direct Alloantigen Presentation and The Generation Of Cross-Dressed Antigen Presenting Cells: A Novel approach To Limit Graft Versus Host Disease Following Allogeneic Hematopoetic Stem Cell Transplantation
Volume: 122
11/15/2013 Authors: Rangaraju S; Choi J; Giver CR; Waller EK
Allogeneic HSCT Patients Receiving More RBC Transfusions Are At Increased Risk For Development Of Grade 2-4 Acute Graft-Versus-Host Disease
Volume: 122
11/15/2013 Authors: Giver CR; Ali Z; Barclay S; Hosaba S; Li Q; Roback J; Waller EK
Blocking VIP Signaling Abrogates Upregulation Of PD1 and Increases Proliferation Of Allo-Reactive T-Cells In a Mixed Lymphocyte Reaction
Volume: 122
11/15/2013 Authors: Summerbell ER; Giver CR; Rangaraju S; Darlak KA; Waller EK
Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade
Volume: 19 Page(s): S139 - S139
02/01/2013 Authors: Kozyr N; Ramakrishnan S; Polnett A; Hamby K; Tiwari D; Watkins B; Deane T; Stempora L; Elder E; Esiashvili N
Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice.
PLoS One Volume: 8 Page(s): e64837
01/01/2013 Authors: Forghani P; Harris W; Giver CR; Mirshafiey A; Galipeau J; Waller EK
Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade
Volume: 120
11/16/2012 Authors: Kozyr N; Ramakrishnan S; Polnett A; Hamby K; Tiwari D; Deane T; Stempora L; Jenkins J; Strobert E; Garcia A
Recovery and rebound of platelet counts in mice after thrombocytopenia induced by combination bortezomib + romidepsin.
Exp Hematol Volume: 40 Page(s): 95 - 96
02/01/2012 Authors: Giver CR; Jaye DL; Waller EK; Lonial S
IFN- and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity.
Blood Volume: 119 Page(s): 1075 - 1085
01/26/2012 Authors: Lu Y; Giver CR; Sharma A; Li JM; Darlak KA; Owens LM; Roback JD; Galipeau J; Waller EK
Blocking Vasoactive Intestinal Peptide Signaling Enhances Anti-Viral Immunity without Increased Graft Versus Host Disease in Murine Allogeneic Bone Marrow Transplantation
Volume: 118 Page(s): 458 - 458
11/18/2011 Authors: Li J-M; Wang Y; Darlak K; Southerland LT; Hossain MS; Giver CR; Waschek JA; Waller EK
Lack of Host Bone Marrow-Derived Interleukin-12 Increased the Incidence of Allograft Rejection in Allogeneic Bone Marrow Transplantation
Volume: 118 Page(s): 1277 - 1277
11/18/2011 Authors: Wang Y; Li J-M; Harris WAC; Giver CR; Waller EK
Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice.
J Immunol Volume: 187 Page(s): 1057 - 1065
07/15/2011 Authors: Li J-M; Southerland L; Hossain MS; Giver CR; Wang Y; Darlak K; Harris W; Waschek J; Waller EK
Rapid recovery from panobinostat (LBH589)-induced thrombocytopenia in mice involves a rebound effect of bone marrow megakaryocytes.
Leukemia Volume: 25 Page(s): 362 - 365
02/01/2011 Authors: Giver CR; Jaye DL; Waller EK; Kaufman JL; Lonial S
Receiver operating characteristic curve analysis of circulating blood dendritic cell precursors and T cells predicts response to extracorporeal photopheresis in patients with chronic graft-versus-host disease.
Transfusion Volume: 50 Page(s): 2424 - 2431
11/01/2010 Authors: Akhtari M; Giver CR; Ali Z; Flowers CR; Gleason CL; Hillyer CD; Kaufman J; Khoury HJ; Langston AA; Lechowicz MJ
Activation, immune polarization, and graft-versus-leukemia activity of donor T cells are regulated by specific subsets of donor bone marrow antigen-presenting cells in allogeneic hemopoietic stem cell transplantation.
J Immunol Volume: 183 Page(s): 7799 - 7809
12/15/2009 Authors: Li J-M; Southerland LT; Lu Y; Darlak KA; Giver CR; McMillin DW; Harris WAC; Jaye DL; Waller EK
Characterization of Cyclic Hematologic Changes Observed in Patients with Cutaneous T-Cell Lymphoma (CTCL) Receiving Romidepsin, a Novel Histone Deacetylase (HDAC) Inhibitor
Volume: 114 Page(s): 1425 - 1425
11/20/2009 Authors: Whittaker S; Kim EJ; Prince M; Demierre MF; Giver C; Lonial S; Pickarz R; Kim YH; Nichols J; Nix D
Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
Immunotherapy Volume: 1 Page(s): 599 - 621
07/01/2009 Authors: Li J-M; Giver CR; Lu Y; Hossain MS; Akhtari M; Waller EK
The HDAC inhibitor panobinostat (LBH589) induces transient thrombocytopenia in mice, with minimal effects on bone marrow megakaryocyte populations
Volume: 69
05/01/2009 Authors: Giver C; Waller E; Lonial S
EXTRACORPOREAL PHOTOPHERESIS THERAPY FOR CHRONIC GRAFT-VERSUS-HOST DISEASE: RESPONSE IS ASSOCIATED WITH CONTENT OF DENDRITIC CELLS AND T-CELLS IN PERIPHERAL BLOOD AT INITIATION OF TREATMENT
Volume: 15 Page(s): 128 - 129
02/01/2009 Authors: Akhtari M; Giver CR; Renfroe HM; Langston AA; Khoury HJ; Flowers CR; Kaufman JL; Lonial S; Lechowicz MJ; Gleason CL
Higher Numbers of Circulating Dendritic Cells and T-Cells Predict Response to Extracorporeal Photopheresis in Patients with Chronic Graft-Versus-Host Disease
Volume: 112 Page(s): 432 - 432
11/16/2008 Authors: Giver CR; Akhtari M; Langston AA; Khoury HJ; Flowers CR; Kaufman JL; Lonial S; Lechowicz MJ; Gleason CL; Vaughn ML
Short-term ionomycin exposure activates naive murine T-Cells and induces a rapid phenotypic shift to memory T-Cell status: Potential for use as a method to reduce GvHD activity of allogeneic T-Cells
Volume: 110 Page(s): 649A - 649A
11/16/2007 Authors: Hossain M; Giver CR; Waller N
The absence of vasoactive intestinal peptide augments allo-reactivity and the anti-viral response in bone marrow transplantation
Volume: 110 Page(s): 959A - 959A
11/16/2007 Authors: Southerland LT; Li J-M; Hossain S; Giver C; Harris W; Waschek J; Waller EK
CD11b-donor dendritic cells elevate donor T-Cell production of interferon-gamma and graft-versus-leukemia activity in allogeneic bone marrow transplantation
Volume: 110 Page(s): 648A - 649A
11/16/2007 Authors: Li J-M; Southerland L; Giver C; McMillion D; Harris W; Jaye DL; Waller N
Mechanism for the immuno-suppresion activity of pentostatin: Selective apoptosis of naive T cell subsets.
BLOOD Volume: 108 Page(s): 380B - 380B
11/16/2006 Authors: Smith MM; Powers W; Giver CR; Waller N; Flowers C
Apoptotic cells break tolerance induced by CD40-CD40L blockade.
Volume: 108 Page(s): 919A - 919A
11/16/2006 Authors: Li J-M; Gorechlad JW; Giver C; Larsen CP; Waller N
Homeostatic expansion of donor FoxP3+CD25+CD4+T cells in recipients of CD4+cells depleted allogeneic hematopoietic graft.
Volume: 108 Page(s): 915A - 915A
11/16/2006 Authors: Hossain MS; Giver CR; Waller N
Graft engineering using ex vivo methods to limit GVHD: fludarabine treatment generates superior GVL effects in allogeneic BMT.
Exp Hematol Volume: 34 Page(s): 895 - 904
07/01/2006 Authors: Li J-M; Giver CR; Waller EK
Graft engineering using ex vivo methods to limit GVHD: Fludarabine treatment generates superior GvL effects in allogeneic BMT
Volume: 12 Page(s): 63 - 64
02/01/2006 Authors: Li JM; Giver CR; Waller EK
Apoptotic donor leukocytes inhibit tolerance and limit mixed chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation
Volume: 12 Page(s): 80 - 80
02/01/2006 Authors: Li JM; Giver CR; Gorechlad J; Larsen CP; Walker EK
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma.
Blood Volume: 106 Page(s): 3777 - 3784
12/01/2005 Authors: Lonial S; Waller EK; Richardson PG; Jagannath S; Orlowski RZ; Giver CR; Jaye DL; Francis D; Giusti S; Torre C
Donor DC subsets polarize donor T-cell immune responses in allogeneic BMT.
Volume: 106 Page(s): 170A - 170A
11/16/2005 Authors: Li JM; Giver C; McMillan D; Harris W; Jaye DL; Walter N
Ex vivo fludarabine selectively depletes human naive T-Cell subsets: A step toward modifying donor lymphocyte infusion.
Volume: 106 Page(s): 312A - 312A
11/16/2005 Authors: Smith MM; Giver CR; Waller EK; Flowers CR
Bortezomib-associated transient and cyclical thrombocytopenia: evidence for lack of marrow cytotoxicity.
Volume: 23 Page(s): 587S - 587S
06/01/2005 Authors: Lonial S; Waller EK; Richardson PG; Jagannath S; Orlowski RZ; Giver CR; Jaye DL; Barlogie B; Heffner LT; Anderson KC
Injection of blastocysts from immunocompetent mice with human HPC having high ALDH activity results in chimeric animals with low-level human contribution in hematopoietic and non-hematopoietic tissues
Volume: 104 Page(s): 880A - 881A
11/16/2004 Authors: Giver CR; Foster SJ; Martin WD; Balber AE; Waller N
Facilitating T-cell immune reconstitution after haploidentical transplantation in adults.
Volume: 33 Page(s): 196 - 197
11/01/2004 Authors: Waller E; Giver C; Somani J; Langston A; Lonial S; Roback J; Jian ML; Hossain M; Redei I
Reconstructing immunity after allogeneic transplantation.
Immunol Res Volume: 29 Page(s): 269 - 282
01/01/2004 Authors: Giver CR; Li J-M; Hossain MS; Lonial S; Waller EK
Facilitating T-cell immune reconstitution after haploidentical transplantation in adults.
Blood Cells Mol Dis Volume: 33 Page(s): 233 - 237
01/01/2004 Authors: Waller EK; Giver CR; Rosenthal H; Somani J; Langston AA; Lonial S; Roback JD; Li J-M; Hossain MS; Redei I
Purified donor CD4 memory T-cells promote immune reconstitution without GvHD in a fully MHC mismatched BMT system.
Volume: 102 Page(s): 701A - 702A
11/16/2003 Authors: Giver CR; Waller EK
Ex vivo fludarabine exposure inhibits graft-versus-host activity of allogeneic T cells while preserving graft-versus-leukemia effects.
Biol Blood Marrow Transplant Volume: 9 Page(s): 616 - 632
10/01/2003 Authors: Giver CR; Montes RO; Mittelstaedt S; Li J-M; Jaye DL; Lonial S; Boyer MW; Waller EK
Fludarabine treatment of allogeneic donor lymphocytes selects for Th2 regulatory T-cells and reduces GvHD activity in MHC mis-matched murine BMT.
Volume: 100 Page(s): 824A - 825A
11/16/2002 Authors: Giver CR; Montes RO; Mittelstaedt S; Jaye DL; Lonial S; Li JM; Boyer MW; Waller EK
Improved therapeutic index of allogenic donor T-Cells following ex vivo treatment of donor T-Cells to limit GvHD while preserving GvL activity.
BLOOD Volume: 100 Page(s): 411B - 411B
11/16/2002 Authors: Li JM; Giver CR; Waller ED
Immuno-regulatory role of donour CD11b+cells in allogeneic BMT: effects on immune reconstitution, GVL and GVHD
Volume: 30 Page(s): 87 - 87
06/01/2002 Authors: Li J; Giver CR; Waller EK
Ex-vivo exposure to fludarabine reduces allo-proliferation and preserves homeostatic proliferation of donor T-cells in MHC mismatched transplants
Volume: 30 Page(s): 86 - 86
06/01/2002 Authors: Giver C; Montes RO; Mittelstaedt S; Lonial S; Li JM; Boyer MW; Waller EK
Fludarabine-treated donor lymphocytes: A novel method to reduce GvHD that preserves graft facilitating and graft v. leukemia activity.
BLOOD Volume: 98 Page(s): 324B - 325B
11/16/2001 Authors: Giver CR; Li JM; Montes RO; Lonial S; Waller N
Modulation of allo-reactivity of human PBMC by ex vivo treatment with fludarabine.
BLOOD Volume: 98 Page(s): 341B - 342B
11/16/2001 Authors: Lonial S; Torre C; Rosenthal H; Giver CR; Waller EK
Persistence of aneuploid immature/primitive hemopoietic sub-populations in mice 8 months after benzene exposure in vivo.
Mutat Res Volume: 491 Page(s): 127 - 138
04/05/2001 Authors: Giver CR; Wong R; Moore DH; Pallavicini MG
Genomic instability in human lymphoid cells exposed to 1 GeV/amu Fe ions.
Phys Med Volume: 17 Suppl 1 Page(s): 238 - 240
01/01/2001 Authors: Grosovsky A; Bethel H; Parks K; Ritter L; Giver C; Gauny S; Wiese C; Kronenberg A
Dermal benzene and trichloroethylene induce aneuploidy in immature hematopoietic subpopulations in vivo.
Environ Mol Mutagen Volume: 37 Page(s): 185 - 194
01/01/2001 Authors: Giver CR; Wong R; Moore DH; Pallavicini MG
Radiation-induced translocations in mice: persistence, chromosome specificity, and influence of genetic background.
Radiat Res Volume: 154 Page(s): 283 - 292
09/01/2000 Authors: Giver CR; Moore DH; Pallavicini MG
Radiation specific patterns of loss of heterozygosity on chromosome 17q.
Mutat Res Volume: 450 Page(s): 201 - 209
05/30/2000 Authors: Giver CR; Grosovsky AJ
Benzene-induced toxicity and aneusomy in murine bone marrow hemopoietic stem cells.
Volume: 94 Page(s): 274A - 274A
11/15/1999 Authors: Wong RS; Giver CR; Pallavicini MG
The translocation frequency response is a complex phenotype that is dissociated from leukemic risk in mice with inherited predisposition to radiation leukemogenesis.
Volume: 94 Page(s): 274A - 274A
11/15/1999 Authors: Giver CR; Moore D; Pallavicini MG
Single and coincident intragenic mutations attributable to gene conversion in a human cell line.
Genetics Volume: 146 Page(s): 1429 - 1439
08/01/1997 Authors: Giver CR; Grosovsky AJ
Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability.
Mol Cell Biol Volume: 16 Page(s): 6252 - 6262
11/01/1996 Authors: Grosovsky AJ; Parks KK; Giver CR; Nelson SL
Mutational spectrum of X-ray induced TK- human cell mutants.
Carcinogenesis Volume: 16 Page(s): 267 - 275
02/01/1995 Authors: Giver CR; Nelson SL; Cha MY; Pongsaensook P; Grosovsky AJ
Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts.
Mutagenesis Volume: 10 Page(s): 53 - 58
01/01/1995 Authors: Dobo KL; Giver CR; Eastmond DA; Rumbos HS; Grosovsky AJ
Loss of heterozygosity at linked microsatellite markers in spontaneous and x-ray induced TK- mutants
Page(s): 527 - 530
01/01/1995 Authors: Grosovsky AJ; Nelson SL; Pongsaensook P; Cha MY; Giver CR
Spectrum of X-ray-induced mutations in the human hprt gene.
Carcinogenesis Volume: 15 Page(s): 495 - 502
03/01/1994 Authors: Nelson SL; Giver CR; Grosovsky AJ
DNA-sequence specificity of mutations at the human thymidine kinase locus.
Mutat Res Volume: 289 Page(s): 231 - 243
10/01/1993 Authors: Grosovsky AJ; Walter BN; Giver CR
Spectrum of spontaneous HPRT- mutations in TK6 human lymphoblasts.
Environ Mol Mutagen Volume: 22 Page(s): 138 - 146
01/01/1993 Authors: Giver CR; Nelson SL; Grosovsky AJ

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Cynthia Giver PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications