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Profile

Cheryl Day PhD

  • Department of Microbiology and Immunology
    Associate Professor
  • (404) 727-4374
  • cheryl.day@emory.edu
  • Pubmed
  • Emory University School of Medicine
    Microbiology and Immunology
    Emory National Primate Research Center - Room 1024
Head shot of Cheryl Day

Overview

Biography:

Dr. Day received her PhD in Virology from Harvard University in 2003. She completed her post-doctoral fellowship at the University of Oxford investigating the phenotype and function of HIV-specific CD8 T cells. While a post-doc at Oxford, she obtained additional funding from the Doris Duke Charitable Foundation to conduct HIV cellular immunology research in Durban, South Africa, and eventually expanded her immunology studies in Durban to include tuberculosis (TB) and HIV co-infection. She subsequently joined the South African Tuberculosis Vaccine Initiative at the University of Cape Town to pursue research on T cell immunology in individuals with latent TB infection and active pulmonary TB disease. In 2010, Dr. Day joined Emory University as an Assistant Professor in the Department of Global Health at the Rollins School of Public Health. In 2013, Dr. Day joined the faculty of the Department of Microbiology & Immunology at Emorys School of Medicine, where she is currently an Associate Professor and a faculty member of the Emory Vaccine Center.

Research Interests:

Dr. Days research program is based on characterization of cellular immune responses in pediatric and adult cohorts across a spectrum of TB and HIV infection states. Specific research areas include: 1) characterization of frequency, phenotype, and function of antigen-specific T cells and relationship to antigen load and disease status; 2) analysis of mechanisms of immune regulation of antigen-specific T cell responses; 3) analysis of NK cell correlates of protection in M. tuberculosis infection; and 4) evaluation of the effect of maternal HIV exposure on the phenotype, transcriptome and epigenome of innate and adaptive immunity to M. tuberculosis in HIV-exposed uninfected infants and children.

Academic Appointment

  • Associate Professor, Microbiology & Immunology, Emory University

Education

Degrees

  • PhD from Harvard University

Research

Publications

  • A plasma metabolic signature to diagnose pulmonary tuberculosis and monitor treatment response.
    J Infect Dis
    05/08/2025 Authors: Collins JM; Bobosha K; Narayanan N; Gandhi NR; Day CL; Rengarajan J; Kempker RR; Lau MSY; Nellis M; Tukvadze N
  • High rates of post-tuberculosis lung disease among persons successfully treated for drug-susceptible and resistant tuberculosis.
    Thorax
    05/07/2025 Authors: Kempker RR; Salindri AD; Avaliani T; Kornfeld H; Auld SC; Jakobia N; Day CL; Subuddhi A; Krish KN; Vashakidze S
  • Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV.
    J Infect Dis Volume: 231 Page(s): 957 - 966
    04/15/2025 Authors: Day CL; Njuguna IN; Cranmer LM; Whatney WE; Pearson RA; Lindestam Arlehamn CS; Sette A; LaCourse SM; Escudero JN; Sasser LE
  • HIV co-infection is associated with increased HLA-DR expression by Mycobacterium tuberculosis-specific CD4 T cells in people with latent tuberculosis infection.
    Tuberculosis (Edinb) Volume: 151 Page(s): 102607
    03/01/2025 Authors: Khayumbi J; Sasser LE; McLaughlin TA; Ongalo J; Tonui J; Ouma SG; Campbell A; Odhiambo FH; Gandhi NR; Kiprotich C
  • Active Tuberculosis Is Associated with Depletion of HIV-Specific CD4 and CD8 T Cells in People with HIV.
    AIDS Res Hum Retroviruses Volume: 40 Page(s): 417 - 427
    07/01/2024 Authors: Khayumbi J; Sasser LE; McLaughlin TA; Muchiri B; Ongalo J; Tonui J; Ouma SG; Campbell A; Odhiambo FH; Kiprotich C
  • Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection.
    bioRxiv
    03/06/2024 Authors: Ogongo P; Wassie L; Tran A; Columbus D; Sharling L; Ouma G; Ouma SG; Bobosha K; Lindestam Arlehamn CS; Gandhi NR
  • Mycobacterium tuberculosis-specific cytokine responses according to HIV status among household contacts of people with TB.
    Tuberculosis (Edinb) Volume: 139 Page(s): 102328
    03/01/2023 Authors: Day CL; Willis F; Staitieh BS; Campbell A; Martinson N; Gandhi NR; Auld SC
  • Corrigendum: Defining discriminatory antibody fingerprints in active and latent tuberculosis.
    Front Immunol Volume: 14 Page(s): 1329784
    01/01/2023 Authors: Nziza N; Cizmeci D; Davies L; Irvine EB; Jung W; Fenderson BA; de Kock M; Hanekom WA; Franken KLMC; Day CL
  • Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel.
    Lancet HIV Volume: 9 Page(s): e791 - e800
    11/01/2022 Authors: Miner MD; Hatherill M; Mave V; Gray GE; Nachman S; Read SW; White RG; Hesseling A; Cobelens F; Patel S
  • What's Old and New in Tuberculosis Vaccines for Children.
    J Pediatric Infect Dis Soc Volume: 11 Page(s): S110 - S116
    10/31/2022 Authors: Cranmer LM; Cotton MF; Day CL; Nemes E
  • Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs.
    J Clin Invest Volume: 132
    09/15/2022 Authors: Sharan R; Ganatra SR; Singh DK; Cole J; Foreman TW; Thippeshappa R; Peloquin CA; Shivanna V; Gonzalez O; Day CL
  • The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia.
    Open Forum Infect Dis Volume: 9 Page(s): ofac323
    07/01/2022 Authors: Smith AGC; Kempker RR; Wassie L; Bobosha K; Nizam A; Gandhi NR; Auld SC; Magee MJ; Blumberg HM; Tuberculosis Research Unit: Role of Antigen Specific Responses in the Control of TB (TBRU-ASTRa) Study Group
  • Increased Risk of Incident Diabetes Among Individuals With Latent Tuberculosis Infection.
    Diabetes Care Volume: 45 Page(s): 880 - 887
    04/01/2022 Authors: Magee MJ; Khakharia A; Gandhi NR; Day CL; Kornfeld H; Rhee MK; Phillips LS
  • CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.
    Nat Commun Volume: 13 Page(s): 78
    01/10/2022 Authors: James CA; Xu Y; Aguilar MS; Jing L; Layton ED; Gilleron M; Minnaard AJ; Scriba TJ; Day CL; Warren EH
  • Ferrets as a model for tuberculosis transmission.
    Front Cell Infect Microbiol Volume: 12 Page(s): 873416
    01/01/2022 Authors: Gupta T; Somanna N; Rowe T; LaGatta M; Helms S; Owino SO; Jelesijevic T; Harvey S; Jacobs W; Voss T
  • Defining Discriminatory Antibody Fingerprints in Active and Latent Tuberculosis.
    Front Immunol Volume: 13 Page(s): 856906
    01/01/2022 Authors: Nziza N; Cizmeci D; Davies L; Irvine EB; Jung W; Fenderson BA; de Kock M; Hanekom WA; Franken KLMC; Day CL
  • Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive T cell repertoire.
    Sci Transl Med Volume: 13 Page(s): eabe7430
    12/01/2021 Authors: von Borstel A; Chevour P; Arsovski D; Krol JMM; Howson LJ; Berry AA; Day CL; Ogongo P; Ernst JD; Nomicos EYH
  • A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood.
    PLoS Negl Trop Dis Volume: 15 Page(s): e0010018
    12/01/2021 Authors: Zhou AX; Scriba TJ; Day CL; Hagge DA; Seshadri C
  • Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya.
    J Acquir Immune Defic Syndr Volume: 86 Page(s): 157 - 163
    02/01/2021 Authors: McLaughlin TA; Nizam A; Hayara FO; Ouma GS; Campbell A; Khayumbi J; Ongalo J; Ouma SG; Shah NS; Altman JD
  • Activation-Induced Marker Expression Identifies Mycobacterium tuberculosis-Specific CD4 T Cells in a Cytokine-Independent Manner in HIV-Infected Individuals with Latent Tuberculosis.
    Immunohorizons Volume: 4 Page(s): 573 - 584
    10/02/2020 Authors: Barham MS; Whatney WE; Khayumbi J; Ongalo J; Sasser LE; Campbell A; Franczek M; Kabongo MM; Ouma SG; Hayara FO
  • Adults from Kisumu, Kenya have robust T cell responses to Schistosoma mansoni, which are modulated by tuberculosis.
    PLoS Negl Trop Dis Volume: 14 Page(s): e0008764
    10/01/2020 Authors: McLaughlin TA; Khayumbi J; Ongalo J; Matete D; Tonui J; Muchiri B; Sasser LE; Campbell A; Allana S; Ouma SG
  • Tryptophan catabolism reflects disease activity in human tuberculosis.
    JCI Insight Volume: 5
    05/21/2020 Authors: Collins JM; Siddiqa A; Jones DP; Liu K; Kempker RR; Nizam A; Shah NS; Ismail N; Ouma SG; Tukvadze N
  • HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection.
    mSphere Volume: 5
    05/20/2020 Authors: van Woudenbergh E; Irvine EB; Davies L; de Kock M; Hanekom WA; Day CL; Fortune S; Alter G
  • Adults with Mycobacterium tuberculosis infection and pre-diabetes have increased levels of QuantiFERON interferon-gamma responses.
    Tuberculosis (Edinb) Volume: 122 Page(s): 101935
    05/01/2020 Authors: Magee MJ; Trost SL; Salindri AD; Amere G; Day CL; Gandhi NR
  • Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques.
    Am J Respir Crit Care Med Volume: 201 Page(s): 469 - 477
    02/15/2020 Authors: Foreman TW; Bucan AN; Mehra S; Peloquin C; Doyle LA; Russell-Lodrigue K; Gandhi NR; Altman J; Day CL; Ernst JD
  • Distinct Human NK Cell Phenotypes and Functional Responses to Mycobacterium tuberculosis in Adults From TB Endemic and Non-endemic Regions.
    Front Cell Infect Microbiol Volume: 10 Page(s): 120
    01/01/2020 Authors: Harris LD; Khayumbi J; Ongalo J; Sasser LE; Tonui J; Campbell A; Odhiambo FH; Ouma SG; Alter G; Gandhi NR
  • CD4 T Cells in Mycobacterium tuberculosis and Schistosoma mansoni Co-infected Individuals Maintain Functional TH1 Responses.
    Front Immunol Volume: 11 Page(s): 127
    01/01/2020 Authors: McLaughlin TA; Khayumbi J; Ongalo J; Tonui J; Campbell A; Allana S; Gurrion Ouma S; Odhiambo FH; Gandhi NR; Day CL
  • HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease.
    Front Immunol Volume: 10 Page(s): 1983
    01/01/2019 Authors: Barham MS; Abrahams DA; Khayumbi J; Ongalo J; Tonui J; Campbell A; de Kock M; Ouma SG; Odhiambo FH; Hanekom WA
  • Higher Interferon-gamma (IFN-gamma) Antigen Responses Among US Adults with Pre-Diabetes and Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012
    Volume: 199
    01/01/2019 Authors: Trost S; Day C; Salindri A; Amere G; Gandhi N; Magee M
  • A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis.
    J Immunol Volume: 201 Page(s): 888 - 896
    08/01/2018 Authors: DeWitt WS; Yu KKQ; Wilburn DB; Sherwood A; Vignali M; Day CL; Scriba TJ; Robins HS; Swanson WJ; Emerson RO
  • A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.
    J Immunol Volume: 200 Page(s): 3008 - 3019
    04/15/2018 Authors: Whatney WE; Gandhi NR; Lindestam Arlehamn CS; Nizam A; Wu H; Quezada MJ; Campbell A; Allana S; Kabongo MM; Khayumbi J
  • PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.
    Front Immunol Volume: 9 Page(s): 1995
    01/01/2018 Authors: Day CL; Abrahams DA; Bunjun R; Stone L; de Kock M; Walzl G; Wilkinson RJ; Burgers WA; Hanekom WA
  • HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.
    J Immunol Volume: 199 Page(s): 2069 - 2080
    09/15/2017 Authors: Day CL; Abrahams DA; Harris LD; van Rooyen M; Stone L; de Kock M; Hanekom WA
  • IFN- Release Assay Result Is Associated with Disease Site and Death in Active Tuberculosis.
    Ann Am Thorac Soc Volume: 13 Page(s): 2151 - 2158
    12/01/2016 Authors: Auld SC; Lee SH; Click ES; Miramontes R; Day CL; Gandhi NR; Heilig CM
  • A Functional Role for Antibodies in Tuberculosis.
    Cell Volume: 167 Page(s): 433 - 443.e14
    10/06/2016 Authors: Lu LL; Chung AW; Rosebrock TR; Ghebremichael M; Yu WH; Grace PS; Schoen MK; Tafesse F; Martin C; Leung V
  • Deep sequencing of T-cells specific for a mycobacterial glycolipid reveals shared T-cell receptor motifs with diagnostic potential in population-based studies
    Volume: 46 Page(s): 1173 - 1174
    08/01/2016 Authors: DeWitt W; Quan K; Emerson R; Sherwood A; DeRosa S; Finak G; Gottardo R; Day C; Scriba T; Robins H
  • Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response.
    Front Immunol Volume: 7 Page(s): 527
    01/01/2016 Authors: Schaller MA; Allen RM; Kimura S; Day CL; Kunkel SL
  • First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults.
    Vaccine Volume: 33 Page(s): 4130 - 4140
    08/07/2015 Authors: Luabeya AKK; Kagina BMN; Tameris MD; Geldenhuys H; Hoff ST; Shi Z; Kromann I; Hatherill M; Mahomed H; Hanekom WA
  • Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting.
    Vaccine Volume: 33 Page(s): 4025 - 4034
    07/31/2015 Authors: Penn-Nicholson A; Geldenhuys H; Burny W; van der Most R; Day CL; Jongert E; Moris P; Hatherill M; Ofori-Anyinam O; Hanekom W
  • Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.
    J Clin Invest Volume: 125 Page(s): 1827 - 1838
    05/01/2015 Authors: Adekambi T; Ibegbu CC; Cagle S; Kalokhe AS; Wang YF; Hu Y; Day CL; Ray SM; Rengarajan J
  • Impaired degranulation and proliferative capacity of Mycobacterium tuberculosis-specific CD8+ T cells in HIV-infected individuals with latent tuberculosis.
    J Infect Dis Volume: 211 Page(s): 635 - 640
    02/15/2015 Authors: Kalokhe AS; Adekambi T; Ibegbu CC; Ray SM; Day CL; Rengarajan J
  • Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
    Clin Infect Dis Volume: 60 Page(s): 432 - 437
    02/01/2015 Authors: Rozot V; Patrizia A; Vigano S; Mazza-Stalder J; Idrizi E; Day CL; Perreau M; Lazor-Blanchet C; Ohmiti K; Goletti D
  • Distinct T-cell responses when BCG vaccination is delayed from birth to 6 weeks of age in Ugandan infants.
    J Infect Dis Volume: 209 Page(s): 887 - 897
    03/01/2014 Authors: Lutwama F; Kagina BM; Wajja A; Waiswa F; Mansoor N; Kirimunda S; Hughes EJ; Kiwanuka N; Joloba ML; Musoke P
  • Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment.
    PLoS One Volume: 9 Page(s): e94949
    01/01/2014 Authors: Day CL; Moshi ND; Abrahams DA; van Rooyen M; O'rie T; de Kock M; Hanekom WA
  • Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.
    Eur J Immunol Volume: 43 Page(s): 2409 - 2420
    09/01/2013 Authors: Dintwe OB; Day CL; Smit E; Nemes E; Gray C; Tameris M; McShane H; Mahomed H; Hanekom WA; Scriba TJ
  • Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults.
    Am J Respir Crit Care Med Volume: 188 Page(s): 492 - 502
    08/15/2013 Authors: Day CL; Tameris M; Mansoor N; van Rooyen M; de Kock M; Geldenhuys H; Erasmus M; Makhethe L; Hughes EJ; Gelderbloem S
  • Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease.
    Eur J Immunol Volume: 43 Page(s): 1568 - 1577
    06/01/2013 Authors: Rozot V; Vigano S; Mazza-Stalder J; Idrizi E; Day CL; Perreau M; Lazor-Blanchet C; Petruccioli E; Hanekom W; Goletti D
  • SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis.
    S Afr Med J Volume: 102 Page(s): 438 - 441
    03/02/2012 Authors: Hanekom WA; Hawkridge A; Mahomed H; Scriba TJ; Tameris M; Hughes J; Hatherill M; Day CL; Hussey GD
  • HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load.
    AIDS Res Hum Retroviruses Volume: 27 Page(s): 1311 - 1316
    12/01/2011 Authors: Nqoko B; Day CL; Mansoor N; De Kock M; Hughes EJ; Hawkridge T; Kaplan G; Boom WH; Hussey GD; Hanekom WA
  • Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.
    J Immunol Volume: 187 Page(s): 2222 - 2232
    09/01/2011 Authors: Day CL; Abrahams DA; Lerumo L; Janse van Rensburg E; Stone L; O'rie T; Pienaar B; de Kock M; Kaplan G; Mahomed H
  • Dominant TNF-alpha Mycobacterium Tuberculosis-specific CD4 T-cell responses discriminate between latent infection and active disease
    Volume: 186
    04/01/2011 Authors: Harari A; Rozot V; Enders FB; Perreau M; Stalder JM; Nicod LP; Cavassini M; Calandra T; Ianchet CL; Jaton K
  • Dominant TNF-+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease.
    Nat Med Volume: 17 Page(s): 372 - 376
    03/01/2011 Authors: Harari A; Rozot V; Bellutti Enders F; Perreau M; Stalder JM; Nicod LP; Cavassini M; Calandra T; Blanchet CL; Jaton K
  • A molecular assay for sensitive detection of pathogen-specific T-cells.
    PLoS One Volume: 6 Page(s): e20606
    01/01/2011 Authors: Kasprowicz VO; Mitchell JE; Chetty S; Govender P; Huang K-HG; Fletcher HA; Webster DP; Brown S; Kasmar A; Millington K
  • HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria.
    Am J Respir Crit Care Med Volume: 180 Page(s): 1262 - 1270
    12/15/2009 Authors: Kalsdorf B; Scriba TJ; Wood K; Day CL; Dheda K; Dawson R; Hanekom WA; Lange C; Wilkinson RJ
  • Upregulation of PD-1 and CTLA-4 on HIV-specific T cells in HIV-infected infants
    Volume: 6
    01/01/2009 Authors: Nqoko BS; Day C; Mansoor N; de Kock M; Hughes J; Hussey G; Hanekom W
  • Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
    PLoS One Volume: 4 Page(s): e5013
    01/01/2009 Authors: Ramduth D; Day CL; Thobakgale CF; Mkhwanazi NP; de Pierres C; Reddy S; van der Stok M; Mncube Z; Nair K; Moodley ES
  • Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.
    J Infect Dis Volume: 197 Page(s): 990 - 999
    04/01/2008 Authors: Day CL; Mkhwanazi N; Reddy S; Mncube Z; van der Stok M; Klenerman P; Walker BD
  • Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
    AIDS Res Hum Retroviruses Volume: 24 Page(s): 265 - 270
    02/01/2008 Authors: Ramduth D; Thobakgale CF; Mkhwanazi NP; De Pierres C; Reddy S; van der Stok M; Mncube Z; Mphatswe W; Blanckenberg N; Cengimbo A
  • Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
    AIDS Res Hum Retroviruses Volume: 24 Page(s): 72 - 82
    01/01/2008 Authors: Ngumbela KC; Day CL; Mncube Z; Nair K; Ramduth D; Thobakgale C; Moodley E; Reddy S; de Pierres C; Mkhwanazi N
  • Cutaneous extensively drug-resistant tuberculosis.
    Am J Trop Med Hyg Volume: 77 Page(s): 551 - 554
    09/01/2007 Authors: Olson DP; Day CL; Magula NP; Sahid F; Moosa M-YS
  • Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.
    PLoS One Volume: 2 Page(s): e649
    07/25/2007 Authors: Lucas M; Ulsenheimer A; Pfafferot K; Heeg MHJ; Gaudieri S; Grner N; Rauch A; Gerlach JT; Jung M-C; Zachoval R
  • Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
    J Virol Volume: 81 Page(s): 434 - 438
    01/01/2007 Authors: Day CL; Kiepiela P; Leslie AJ; van der Stok M; Nair K; Ismail N; Honeyborne I; Crawford H; Coovadia HM; Goulder PJR
  • Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.
    Science Volume: 314 Page(s): 454 - 458
    10/20/2006 Authors: Floto RA; MacAry PA; Boname JM; Mien TS; Kampmann B; Hair JR; Huey OS; Houben ENG; Pieters J; Day C
  • Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
    J Immunol Volume: 177 Page(s): 4699 - 4708
    10/01/2006 Authors: Leslie A; Price DA; Mkhize P; Bishop K; Rathod A; Day C; Crawford H; Honeyborne I; Asher TE; Luzzi G
  • HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
    Virology Volume: 353 Page(s): 366 - 373
    09/30/2006 Authors: Wherry EJ; Day CL; Draenert R; Miller JD; Kiepiela P; Woodberry T; Brander C; Addo M; Klenerman P; Ahmed R
  • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
    Nature Volume: 443 Page(s): 350 - 354
    09/21/2006 Authors: Day CL; Kaufmann DE; Kiepiela P; Brown JA; Moodley ES; Reddy S; Mackey EW; Miller JD; Leslie AJ; DePierres C
  • Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
    J Immunol Volume: 176 Page(s): 4699 - 4705
    04/15/2006 Authors: Honeyborne I; Rathod A; Buchli R; Ramduth D; Moodley E; Rathnavalu P; Chetty S; Day C; Brander C; Hildebrand W
  • Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining.
    J Immunol Volume: 175 Page(s): 6334 - 6343
    11/15/2005 Authors: Scriba TJ; Purbhoo M; Day CL; Robinson N; Fidler S; Fox J; Weber JN; Klenerman P; Sewell AK; Phillips RE
  • Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
    J Infect Dis Volume: 192 Page(s): 1588 - 1596
    11/01/2005 Authors: Ramduth D; Chetty P; Mngquandaniso NC; Nene N; Harlow JD; Honeyborne I; Ntumba N; Gappoo S; Henry C; Jeena P
  • Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.
    J Virol Volume: 79 Page(s): 12979 - 12988
    10/01/2005 Authors: Lauer GM; Lucas M; Timm J; Ouchi K; Kim AY; Day CL; Schulze Zur Wiesch J; Paranhos-Baccala G; Sheridan I; Casson DR
  • Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
    J Immunol Volume: 175 Page(s): 3603 - 3613
    09/15/2005 Authors: Schulze zur Wiesch J; Lauer GM; Day CL; Kim AY; Ouchi K; Duncan JE; Wurcel AG; Timm J; Jones AM; Mothe B
  • Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.
    Hepatology Volume: 41 Page(s): 1019 - 1028
    05/01/2005 Authors: Semmo N; Day CL; Ward SM; Lucas M; Harcourt G; Loughry A; Klenerman P
  • HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.
    J Clin Invest Volume: 115 Page(s): 443 - 450
    02/01/2005 Authors: Scriba TJ; Zhang H-T; Brown HL; Oxenius A; Tamm N; Fidler S; Fox J; Weber JN; Klenerman P; Day CL
  • Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
    Nature Volume: 432 Page(s): 769 - 775
    12/09/2004 Authors: Kiepiela P; Leslie AJ; Honeyborne I; Ramduth D; Thobakgale C; Chetty S; Rathnavalu P; Moore C; Pfafferott KJ; Hilton L
  • High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
    Gastroenterology Volume: 127 Page(s): 924 - 936
    09/01/2004 Authors: Lauer GM; Barnes E; Lucas M; Timm J; Ouchi K; Kim AY; Day CL; Robbins GK; Casson DR; Reiser M
  • Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells.
    J Virol Volume: 78 Page(s): 7284 - 7287
    07/01/2004 Authors: Lucas M; Day CL; Wyer JR; Cunliffe SL; Loughry A; McMichael AJ; Klenerman P
  • Progress in defining CD4 helper cell responses in chronic viral infections.
    J Exp Med Volume: 198 Page(s): 1773 - 1777
    12/15/2003 Authors: Day CL; Walker BD
  • Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.
    J Clin Invest Volume: 112 Page(s): 831 - 842
    09/01/2003 Authors: Day CL; Seth NP; Lucas M; Appel H; Gauthier L; Lauer GM; Robbins GK; Szczepiorkowski ZM; Casson DR; Chung RT
  • Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.
    Gastroenterology Volume: 124 Page(s): 1946 - 1949
    06/01/2003 Authors: Somsouk M; Lauer GM; Casson D; Terella A; Day CL; Walker BD; Chung RT
  • Herpes simplex virus replication compartments can form by coalescence of smaller compartments.
    Virology Volume: 309 Page(s): 232 - 247
    05/10/2003 Authors: Taylor TJ; McNamee EE; Day C; Knipe DM
  • Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection.
    J Virol Volume: 76 Page(s): 12584 - 12595
    12/01/2002 Authors: Day CL; Lauer GM; Robbins GK; McGovern B; Wurcel AG; Gandhi RT; Chung RT; Walker BD
  • Comprehensive longitudinal analysis of cellular immune responses and viral evolution in a person with acute HCV infection requiring antiviral treatment.
    Volume: 36 Page(s): 543A - 543A
    10/01/2002 Authors: Lauer GM; Lucas M; Chung RT; Ouchi K; Day CL; Kim AY; Klenerman P; Walker BD
  • Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.
    J Virol Volume: 76 Page(s): 6104 - 6113
    06/01/2002 Authors: Lauer GM; Ouchi K; Chung RT; Nguyen TN; Day CL; Purkis DR; Reiser M; Kim AY; Lucas M; Klenerman P
  • Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses.
    J Virol Volume: 76 Page(s): 2817 - 2826
    03/01/2002 Authors: Lauer GM; Nguyen TN; Day CL; Robbins GK; Flynn T; McGowan K; Rosenberg ES; Lucas M; Klenerman P; Chung RT
  • Comprehensive analysis of the HCV-specific CD8+T cell response in individuals with chronic or resolved HCV infection.
    Volume: 34 Page(s): 432A - 432A
    10/01/2001 Authors: Lauer GM; Nguyen TN; Day CL; Klenerman P; Chung RT; Walker BD
  • Breadth and specificity of CD4+T cells in resolved hepatitis C virus infection.
    Volume: 34 Page(s): 484A - 484A
    10/01/2001 Authors: Day CL; Lauer GM; Nguyen TN; Chung RT; Walker BD
  • Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
    J Virol Volume: 75 Page(s): 6279 - 6291
    07/01/2001 Authors: Day CL; Shea AK; Altfeld MA; Olson DP; Buchbinder SP; Hecht FM; Rosenberg ES; Walker BD; Kalams SA
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