Charles Bou Nader
- Department of Biochemistry
Assistant Professor
-
Emory University School of Medicine
Biochemistry
1510 Clifton Road NE room 4027
Overview
We focus on mechanistic studies of R-loops and ribonucleoprotein complexes to understand how these assemblies control gene expression and genomic integrity in human health and diseases.
To tackle this important challenge, we use cutting edge biochemical, biophysical, and structural methods such as cryogenic electron microscopy (cryo-EM), X-ray crystallography, and atomic force microscopy (AFM) to define how RNA and RNPs deregulation causes diseases such as neurological disorders, cancers, and autoimmune disorders and their roles in the virus-host interface.
Academic Appointment
- Assistant Professor, Biochemistry, Emory University
- Postdoctoral Fellow, National Institutes of Health
Education
Degrees
- PhD from Sorbonne University
- MS from Sorbonne University
- MS from University of Lille
- BS from Saint Joseph University
Research
Publications
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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling.
Nat Commun Volume: 16 Page(s): 2252
03/06/2025 Authors: Bou-Nader C; Link KA; Suddala KC; Knutson JR; Zhang J -
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis.
Nat Struct Mol Biol Volume: 31 Page(s): 1655 - 1668
11/01/2024 Authors: Skeparnias I; Bou-Nader C; Anastasakis DG; Fan L; Wang Y-X; Hafner M; Zhang J -
Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.
Proc Natl Acad Sci U S A Volume: 121 Page(s): e2409628121
08/27/2024 Authors: Bou-Nader C; Gaikwad S; Bahmanjah S; Zhang F; Hinnebusch AG; Zhang J -
Integrative Approach to Probe Alternative Redox Mechanisms in RNA Modifications.
Acc Chem Res Volume: 56 Page(s): 3142 - 3152
11/21/2023 Authors: Bou-Nader C; Pecqueur L; de Crcy-Lagard V; Hamdane D -
S9.6 Antibody-Enzyme Conjugates for the Detection of DNA-RNA Hybrids.
Bioconjug Chem Volume: 34 Page(s): 834 - 844
05/17/2023 Authors: Wei E; Bou-Nader C; Perry ML; Fattah R; Zhang J; Leppla SH; Bothra A -
Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint.
Cell Rep Volume: 42 Page(s): 112405
04/25/2023 Authors: Valencia-Gallardo C; Aguilar-Salvador D-I; Khakzad H; Cocom-Chan B; Bou-Nader C; Velours C; Zarrouk Y; Le Clainche C; Malosse C; Lima DB -
Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun Volume: 13 Page(s): 1641
03/28/2022 Authors: Bou-Nader C; Bothra A; Garboczi DN; Leppla SH; Zhang J -
Rational engineering enables co-crystallization and structural determination of the HIV-1 matrix-tRNA complex.
STAR Protoc Volume: 3 Page(s): 101056
03/18/2022 Authors: Bou-Nader C; Zhang J -
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell Host Microbe Volume: 29 Page(s): 1421 - 1436.e7
09/08/2021 Authors: Bou-Nader C; Muecksch F; Brown JB; Gordon JM; York A; Peng C; Ghirlando R; Summers MF; Bieniasz PD; Zhang J -
An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun Volume: 12 Page(s): 4542
07/27/2021 Authors: Bou-Nader C; Stull FW; Pecqueur L; Simon P; Gurineau V; Royant A; Fontecave M; Lombard M; Palfey BA; Hamdane D