Blaine Roberts

Department of Biochemistry
Associate Professor

blaine.roberts@emory.edu

Overview

Dr. Roberts is an Associate Professor in the Department of Biochemistry and Department of Neurology at Emory University. He obtained his Bachelor of Science in Chemistry at Montana State University and his PhD in Biochemistry and Biophysics from Oregon State University.

His research group focuses on using protein biochemistry and mass spectrometry to understand Alzheimers, Parkinsons and amyotrophic lateral sclerosis. He has interest in understanding the role of metals in biology and has developed new proteomic technologies to measure metalloproteins. Further, his group is using mass spectrometry and next generation quantitative assays for the development of new blood borne biomarkers for Alzheimers and Parkinsons disease.

Academic Appointment

Associate Professor, Biochemistry, Emory University School of Medicine

Research

Publications

Serotonergic-dependent effects of exercise and elevated stress hormone on small non-coding RNA transcriptomics and proteomics in a mouse model of affective disorders.
Neuropharmacology Volume: 265 Page(s): 110240
03/01/2025 Authors: Kuznetsova M; Wilson C; Cheng L; Pang T; Li S; Roberts BR; Lago LC; Tran H; Hill AF; Hannan AJ
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Mol Biol Cell Volume: 36 Page(s): ar33
03/01/2025 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL
Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation.
bioRxiv
02/20/2025 Authors: Gokhale A; Mendez-Vazquez H; Sampson MM; Moctezuma FGR; Harbuzariu A; Sing A; Zlatic SA; Roberts AM; Prajapati M; Roberts BR
Detection of SARS-CoV-2 RNA and biomarkers in device-captured droplets from the lung
CHEST Pulmonary Page(s): 100137 - 100137
01/01/2025 Authors: Steinberg RS; Chu T-C; Shin D; Ha B; Sun H-Y; Jadhao SJ; Ku DN; Roberts BR; Anderson EJ; Hussaini L
Basic Science and Pathogenesis
Alzheimer's & dementia : the journal of the Alzheimer's Association Volume: 20 Page(s): e090319
12/01/2024 Authors: Roberts BR; Mukherjee S; Roberts AM; Platt ME; MacLean C; Bush AI; Birchall I; Masters CL
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.

11/18/2024 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL
Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease.
Mol Neurodegener Volume: 19 Page(s): 67
10/08/2024 Authors: Guo Q; Ping L; Dammer EB; Duong DM; Yin L; Xu K; Shantaraman A; Fox EJ; Golde TE; Johnson ECB
Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis.
Neurotherapeutics Volume: 21 Page(s): e00432
09/01/2024 Authors: Hilton JBW; Kysenius K; Liddell JR; Mercer SW; Rautengarten C; Hare DJ; Buncic G; Paul B; Murray SS; McLean CA
Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions.
J Proteome Res Volume: 23 Page(s): 2970 - 2985
08/02/2024 Authors: Odenkirk MT; Zheng X; Kyle JE; Stratton KG; Nicora CD; Bloodsworth KJ; Mclean CA; Masters CL; Monroe ME; Doecke JD
The Perfect Storm: The Inflammation-Glia-Glutamate Nexus in Depression and Neurodegeneration
Volume: 95 Page(s): S3 - S3
05/15/2024 Authors: Haroon E; Chen X; Beltran D; Wommack E; Goldstein F; Conneely K; Roberts B; Qiu D; Treadway M; Felger J
Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS.
Sci Rep Volume: 14 Page(s): 5929
03/11/2024 Authors: Hilton JBW; Kysenius K; Liddell JR; Mercer SW; Paul B; Beckman JS; McLean CA; White AR; Donnelly PS; Bush AI
Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease.
Res Sq
02/23/2024 Authors: Guo Q; Ping L; Dammer EB; Yin L; Xu K; Shantaraman A; Fox EJ; Golde TE; Johnson ECB; Roberts BR
Microglial ferroptotic stress causes non-cell autonomous neuronal death.
Mol Neurodegener Volume: 19 Page(s): 14
02/05/2024 Authors: Liddell JR; Hilton JBW; Kysenius K; Billings JL; Nikseresht S; McInnes LE; Hare DJ; Paul B; Mercer SW; Belaidi AA
The Association of Alzheimer's Disease-Related Blood-Based Biomarkers with Cognitive Screening Test Performance in the Congolese Population in Kinshasa.
J Alzheimers Dis Volume: 97 Page(s): 1353 - 1363
01/01/2024 Authors: Schwinne M; Alonso A; Roberts BR; Hickle S; Verberk IMW; Epenge E; Gikelekele G; Tsengele N; Kavugho I; Mampunza S
The Association of Alzheimer's Disease-related Blood-based Biomarkers with Cognitive Screening Test Performance in the Congolese Population in Kinshasa.
medRxiv
10/31/2023 Authors: Schwinne M; Alonso A; Roberts BR; Hickle S; Verberk IM; Epenge E; Gikelekele G; Tsengele N; Kavugho I; Mampunza S
A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer's disease.
Sci Transl Med Volume: 15 Page(s): eadg4122
09/06/2023 Authors: Haque R; Watson CM; Liu J; Carter EK; Duong DM; Lah JJ; Wingo AP; Roberts BR; Johnson ECB; Saykin AJ
A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimers disease
Science Translational Medicine Volume: 15
09/06/2023 Authors: Haque R; Watson CM; Liu J; Carter EK; Duong DM; Lah JJ; Wingo AP; Roberts BR; Johnson ECB; Saykin AJ
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Nat Med Volume: 29 Page(s): 1979 - 1988
08/01/2023 Authors: Johnson ECB; Bian S; Haque RU; Carter EK; Watson CM; Gordon BA; Ping L; Duong DM; Epstein MP; McDade E
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease.
Mol Neurodegener Volume: 18 Page(s): 48
07/19/2023 Authors: Modeste ES; Ping L; Watson CM; Duong DM; Dammer EB; Johnson ECB; Roberts BR; Lah JJ; Levey AI; Seyfried NT
APOE expression and secretion are modulated by mitochondrial dysfunction.
Elife Volume: 12
05/12/2023 Authors: Wynne ME; Ogunbona O; Lane AR; Gokhale A; Zlatic SA; Xu C; Wen Z; Duong DM; Rayaprolu S; Ivanova A
Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease.
Sci Data Volume: 10 Page(s): 261
05/09/2023 Authors: Watson CM; Dammer EB; Ping L; Duong DM; Modeste E; Carter EK; Johnson ECB; Levey AI; Lah JJ; Roberts BR
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
Nat Commun Volume: 14 Page(s): 1638
04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers.
J Neurol Neurosurg Psychiatry Volume: 94 Page(s): 211 - 219
03/01/2023 Authors: Ayton S; Janelidze S; Kalinowski P; Palmqvist S; Belaidi AA; Stomrud E; Roberts A; Roberts B; Hansson O; Bush AI
Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer's Disease.
Res Sq
02/28/2023 Authors: Tandon R; Zhao L; Watson CM; Elmor M; Heilman C; Sanders K; Hales CM; Yang H; Loring DW; Goldstein FC
Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimers Disease

02/28/2023 Authors: Lah J; Tandon R; Zhao L; Watson C; Elmor M; Heilman C; Sanders K; Hales C; Yang H; Loring D
Quantitative proteomics of tau and A in detergent fractions from Alzheimer's disease brains.
J Neurochem Volume: 164 Page(s): 529 - 552
02/01/2023 Authors: Mukherjee S; Dubois C; Perez K; Varghese S; Birchall IE; Leckey M; Davydova N; McLean C; Nisbet RM; Roberts BR
Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study.
J Alzheimers Dis Rep Volume: 7 Page(s): 165 - 172
01/01/2023 Authors: Roberts BR; Laffoon SB; Roberts AM; Porter T; Fowler C; Masters CL; Dratz EA; Laws SM
Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo--N-Acetylglucosaminidases.
Methods Mol Biol Volume: 2674 Page(s): 147 - 167
01/01/2023 Authors: Du JJ; Sastre D; Trastoy B; Roberts B; Deredge D; Klontz EH; Flowers MW; Sultana N; Guerin ME; Sundberg EJ
Association of plasma biomarkers with cognitive function in persons with dementia and cognitively healthy in the Democratic Republic of Congo.
Alzheimers Dement (Amst) Volume: 15 Page(s): e12496
01/01/2023 Authors: Ikanga J; Patel SS; Roberts BR; Schwinne M; Hickle S; Verberk IMW; Epenge E; Gikelekele G; Tshengele N; Kavugho I
From Blue to Gray: Inflammation, Aging and Neurodegeneration in Depression
Volume: 47 Page(s): 246 - 247
12/01/2022 Authors: Haroon E; Beltran D; Chen X; Wommack E; Roberts B; Qiu D; Goldstein F; Treadway M; Felger J; Miller A
From Blue to Gray: Inflammation, Aging and Neurodegeneration in Depression
Volume: 47 Page(s): 246 - 247
12/01/2022 Authors: Haroon E; Beltran D; Chen X; Wommack E; Roberts B; Qiu D; Goldstein F; Treadway M; Felger J; Miller A
The mitochondrial RNA granule modulates manganese-dependent cell toxicity.
Mol Biol Cell Volume: 33 Page(s): ar108
10/01/2022 Authors: Werner E; Gokhale A; Ackert M; Xu C; Wen Z; Roberts AM; Roberts BR; Vrailas-Mortimer A; Crocker A; Faundez V
Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software.
Anal Bioanal Chem Volume: 414 Page(s): 5683 - 5693
07/01/2022 Authors: Mukherjee S; Fjeldsted JC; Masters CL; Roberts BR
Sulfur- and phosphorus-standardized metal quantification of biological specimens using inductively coupled plasma mass spectrometry.
STAR Protoc Volume: 3 Page(s): 101334
06/17/2022 Authors: Lane A; Gokhale A; Werner E; Roberts A; Freeman A; Roberts B; Faundez V
The Neuroinflammatory Acute Phase Response in Parkinsonian-Related Disorders.
Mov Disord Volume: 37 Page(s): 993 - 1003
05/01/2022 Authors: Ayton S; Hall S; Janelidze S; Kalinowski P; Palmqvist S; Belaidi AA; Roberts B; Roberts A; Stomrud E; Bush AI
Quantitative Phosphoproteomics Reveals Extensive Protein Phosphorylation Dysregulation in the Cerebral Cortex of Huntington's Disease Mice Prior to Onset of Symptoms.
Mol Neurobiol Volume: 59 Page(s): 2456 - 2471
04/01/2022 Authors: Mees I; Tran H; Roberts A; Lago L; Li S; Roberts BR; Hannan AJ; Renoir T
Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.
Nat Commun Volume: 13 Page(s): 834
02/07/2022 Authors: Roe JM; Vidal-Pieiro D; Srensen ; Brandmaier AM; Dzel S; Gonzalez HA; Kievit RA; Knights E; Khn S; Lindenberger U
Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease.
Proteome Sci Volume: 20 Page(s): 2
01/26/2022 Authors: Laffoon SB; Doecke JD; Roberts AM; Vance JA; Reeves BD; Pertile KK; Rumble RL; Fowler CJ; Trounson B; Ames D
The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

01/04/2022 Authors: Werner E; Gokhale A; Ackert M; Xu C; Wen Z; Roberts AM; Roberts BR; Vrailas-Mortimer A; Crocker A; Faundez V
Differential protein expression due to Se deficiency and Se toxicity in rat liver.
J Nutr Biochem Volume: 98 Page(s): 108831
12/01/2021 Authors: Cardoso BR; Lago L; Dordevic AL; Kapp EA; Raines AM; Sunde RA; Roberts BR
Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model.
J Clin Invest Volume: 131
12/01/2021 Authors: Li M; Jancovski N; Jafar-Nejad P; Burbano LE; Rollo B; Richards K; Drew L; Sedo A; Heighway J; Pachernegg S
Semi-quantitative methods for multi-site deglycosylation events
Volume: 31 Page(s): 1733 - 1734
12/01/2021 Authors: Du J; Roberts B; Sundberg E; Deredge D
A six-metabolite panel as potential blood-based biomarkers for Parkinson's disease.
NPJ Parkinsons Dis Volume: 7 Page(s): 94
10/14/2021 Authors: Klatt S; Doecke JD; Roberts A; Boughton BA; Masters CL; Horne M; Roberts BR
Citrullination of Amyloid- Peptides in Alzheimer's Disease.
ACS Chem Neurosci Volume: 12 Page(s): 3719 - 3732
10/06/2021 Authors: Mukherjee S; Perez KA; Dubois C; Nisbet RM; Li Q-X; Varghese S; Jin L; Birchall I; Streltsov VA; Vella LJ
Quantification of metallothionein-III in brain tissues using liquid chromatography tandem mass spectrometry.
Anal Biochem Volume: 630 Page(s): 114326
10/01/2021 Authors: Gunn AP; McLean CA; Crouch PJ; Roberts BR
Erratum to: "Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE 4, sex and age" [Prog. Neurobiol. 198 (2021) 101904].
Prog Neurobiol Volume: 204 Page(s): 102071
09/01/2021 Authors: Ayton S; Janelidze S; Roberts B; Palmqvist S; Kalinowski P; Diouf I; Belaidi AA; Stomrud E; Bush AI; Hansson O
GH18 endo--N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans.
J Biol Chem Volume: 297 Page(s): 101011
08/01/2021 Authors: Trastoy B; Du JJ; Li C; Garca-Alija M; Klontz EH; Roberts BR; Donahue TC; Wang L-X; Sundberg EJ; Guerin ME
Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.
Nat Commun Volume: 12 Page(s): 3493
06/09/2021 Authors: Li Y; Imai N; Nicholls HT; Roberts BR; Goyal S; Krisko TI; Ang L-H; Tillman MC; Roberts AM; Baqai M
Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals.
J Neurochem Volume: 156 Page(s): 979 - 987
03/01/2021 Authors: Gunn AP; Wong BX; McLean C; Fowler C; Barnard PJ; Duce JA; Roberts BR; AIBL Research Group
Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE 4, sex and age.
Prog Neurobiol Volume: 198 Page(s): 101904
03/01/2021 Authors: Ayton S; Janelidze S; Roberts B; Palmqvist S; Kalinowski P; Diouf I; Belaidi AA; Stomrud E; Bush AI; Hansson O
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.
Nat Commun Volume: 12 Page(s): 721
02/01/2021 Authors: Roe JM; Vidal-Pieiro D; Srensen ; Brandmaier AM; Dzel S; Gonzalez HA; Kievit RA; Knights E; Khn S; Lindenberger U
Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.
J Neurosci Volume: 41 Page(s): 215 - 233
01/13/2021 Authors: Hartwig C; Mndez GM; Bhattacharjee S; Vrailas-Mortimer AD; Zlatic SA; Freeman AAH; Gokhale A; Concilli M; Werner E; Sapp Savas C
Utilizing Ion Mobility-Mass Spectrometry to Investigate the Unfolding Pathway of Cu/Zn Superoxide Dismutase.
Front Chem Volume: 9 Page(s): 614595
01/01/2021 Authors: Butler KE; Takinami Y; Rainczuk A; Baker ES; Roberts BR
Quantification of N-terminal amyloid- isoforms reveals isomers are the most abundant form of the amyloid- peptide in sporadic Alzheimer's disease.
Brain Commun Volume: 3 Page(s): fcab028
01/01/2021 Authors: Mukherjee S; Perez KA; Lago LC; Klatt S; McLean CA; Birchall IE; Barnham KJ; Masters CL; Roberts BR
Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae.
Commun Biol Volume: 3 Page(s): 694
11/19/2020 Authors: Neville SL; Eijkelkamp BA; Lothian A; Paton JC; Roberts BR; Rosch JW; McDevitt CA
Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.
Nat Commun Volume: 11 Page(s): 4799
09/23/2020 Authors: Zhang Q; Sidorenko J; Couvy-Duchesne B; Marioni RE; Wright MJ; Goate AM; Marcora E; Huang K-L; Porter T; Laws SM
PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity.
Biophys J Volume: 119 Page(s): 128 - 141
07/07/2020 Authors: Foliaki ST; Lewis V; Islam AMT; Senesi M; Finkelstein DI; Ellett LJ; Lawson VA; Adlard PA; Roberts BR; Collins SJ
Choice of mobile phase: Implications for size exclusion chromatography-inductively coupled plasma-mass spectrometry analyses of copper, zinc and iron metalloproteins.
J Chromatogr A Volume: 1616 Page(s): 460806
04/12/2020 Authors: Lago L; Thomas ORB; Roberts BR
Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B.
Sci Rep Volume: 10 Page(s): 4157
03/05/2020 Authors: Maghool S; Fontaine SL; Roberts BR; Kwan AH; Maher MJ
In situ 3D visualization of biomineralization matrix proteins.
J Struct Biol Volume: 209 Page(s): 107448
03/01/2020 Authors: Thomas ORB; Richards KL; Petrou S; Roberts BR; Swearer SE
Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry.
Anal Bioanal Chem Volume: 412 Page(s): 1879 - 1892
03/01/2020 Authors: Klatt S; Roberts A; Lothian A; Masters CL; Cappai R; Fowler C; Roberts BR
Regional iron distribution and soluble ferroprotein profiles in the healthy human brain.
Prog Neurobiol Volume: 186 Page(s): 101744
03/01/2020 Authors: McAllum EJ; Hare DJ; Volitakis I; McLean CA; Bush AI; Finkelstein DI; Roberts BR
Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology.
Metallomics Volume: 12 Page(s): 114 - 132
01/29/2020 Authors: Malakooti N; Roberts B; Pritchard MA; Volitakis I; Kim RC; Lott IT; McLean CA; Finkelstein DI; Adlard PA
Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.
Int J Mol Sci Volume: 21
01/28/2020 Authors: Hancock SM; Portbury SD; Gunn AP; Roberts BR; Bush AI; Adlard PA
Expanding beyond ICP-MS to better understand selenium biochemistry.
Metallomics Volume: 11 Page(s): 1974 - 1983
12/11/2019 Authors: Cardoso BR; Ganio K; Roberts BR
Greater Circulating Copper Concentrations and Copper/Zinc Ratios are Associated with Lower Psychological Distress, But Not Cognitive Performance, in a Sample of Australian Older Adults.
Nutrients Volume: 11
10/17/2019 Authors: Mravunac M; Szymlek-Gay EA; Daly RM; Roberts BR; Formica M; Gianoudis J; O'Connell SL; Nowson CA; Cardoso BR
Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry.
Anal Chem Volume: 91 Page(s): 12129 - 12133
10/01/2019 Authors: Mukherjee S; Fang M; Kok WM; Kapp EA; Thombare VJ; Huguet R; Hutton CA; Reid GE; Roberts BR
Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc.
PLoS Pathog Volume: 15 Page(s): e1007712
04/01/2019 Authors: Foliaki ST; Lewis V; Islam AMT; Ellett LJ; Senesi M; Finkelstein DI; Roberts B; Lawson VA; Adlard PA; Collins SJ
Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn.
Metallomics Volume: 11 Page(s): 128 - 140
01/23/2019 Authors: Lothian A; Lago L; Mukherjee S; Connor AR; Fowler C; McLean CA; Horne M; Masters CL; Cappai R; Roberts BR
The inner ear proteome of fish.
FEBS J Volume: 286 Page(s): 66 - 81
01/01/2019 Authors: Thomas ORB; Swearer SE; Kapp EA; Peng P; Tonkin-Hill GQ; Papenfuss A; Roberts A; Bernard P; Roberts BR
Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.
Neurotherapeutics Volume: 16 Page(s): 192 - 202
01/01/2019 Authors: Cardoso BR; Roberts BR; Malpas CB; Vivash L; Genc S; Saling MM; Desmond P; Steward C; Hicks RJ; Callahan J
Copper isotope compositions of superoxide dismutase and metallothionein from post-mortem human frontal cortex
Inorganics Volume: 7
01/01/2019 Authors: Larner F; McLean CA; Halliday AN; Roberts BR
Selenium Status Is Not Associated with Cognitive Performance: A Cross-Sectional Study in 154 Older Australian Adults.
Nutrients Volume: 10
12/01/2018 Authors: Cardoso BR; Szymlek-Gay EA; Roberts BR; Formica M; Gianoudis J; O'Connell S; Nowson CA; Daly RM
Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice.
Neurotherapeutics Volume: 15 Page(s): 1055 - 1062
10/01/2018 Authors: Belaidi AA; Gunn AP; Wong BX; Ayton S; Appukuttan AT; Roberts BR; Duce JA; Bush AI
Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species.
PLoS Pathog Volume: 14 Page(s): e1007214
08/01/2018 Authors: Foliaki ST; Lewis V; Finkelstein DI; Lawson V; Coleman HA; Senesi M; Islam AMT; Chen F; Sarros S; Roberts B
DELINEATING THE NEUROPROTECTIVE ROLE OF THE AMYLOID PRECURSOR PROTEIN FAMILY IN TRAUMATIC BRAIN INJURY
Volume: 35 Page(s): A57 - A57
08/01/2018 Authors: Cappai R; Inampudi C; Corrigan F; Lam L; Roberts B; Thornton E; Vink R; Ciccotosto G; Crack P; Van den Heuvel C
Alzheimers Disease
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms Page(s): 57 - 79
01/01/2018 Authors: Masters CL; Gu B; Laws S; Lim YY; Roberts B; Villemagne VL; Beyreuther K
The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex.
J Inorg Biochem Volume: 177 Page(s): 328 - 334
12/01/2017 Authors: Graziotto ME; Akerfeldt MC; Gunn AP; Yang K; Somerville MV; Coleman NV; Roberts BR; Hambley TW; New EJ
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of -amyloid load in an AD cohort.
Sci Rep Volume: 7 Page(s): 14057
10/25/2017 Authors: Pedrini S; Gupta VB; Hone E; Doecke J; O'Bryant S; James I; Bush AI; Rowe CC; Villemagne VL; Ames D
Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.
Metallomics Volume: 9 Page(s): 1447 - 1455
10/18/2017 Authors: Genoud S; Roberts BR; Gunn AP; Halliday GM; Lewis SJG; Ball HJ; Hare DJ; Double KL
The APOE 4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease.
ACS Chem Neurosci Volume: 8 Page(s): 1459 - 1464
07/19/2017 Authors: R Cardoso B; Hare DJ; Lind M; McLean CA; Volitakis I; Laws SM; Masters CL; Bush AI; Roberts BR
Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry.
Anal Chem Volume: 89 Page(s): 6136 - 6145
06/06/2017 Authors: Mukherjee S; Kapp EA; Lothian A; Roberts AM; Vasil'ev YV; Boughton BA; Barnham KJ; Kok WM; Hutton CA; Masters CL
Molecular Aspects of a Robust Assay for Ferroxidase Function of Ceruloplasmin.
Inorg Chem Volume: 56 Page(s): 5275 - 5284
05/01/2017 Authors: Cortes L; Roberts BR; Wedd AG; Xiao Z
Biochemically-defined pools of amyloid- in sporadic Alzheimer's disease: correlation with amyloid PET.
Brain Volume: 140 Page(s): 1486 - 1498
05/01/2017 Authors: Roberts BR; Lind M; Wagen AZ; Rembach A; Frugier T; Li Q-X; Ryan TM; McLean CA; Doecke JD; Rowe CC
Direct determination of zinc in plasma by graphite furnace atomic absorption spectrometry using palladium/magnesium and EDTA matrix modification with high temperature pyrolysis
Journal of Analytical Atomic Spectrometry Volume: 32 Page(s): 843 - 847
04/01/2017 Authors: Stevens BJ; Hare DJ; Volitakis I; Cherny RA; Roberts BR
Trace element-protein interactions in endolymph from the inner ear of fish: implications for environmental reconstructions using fish otolith chemistry.
Metallomics Volume: 9 Page(s): 239 - 249
03/22/2017 Authors: Thomas ORB; Ganio K; Roberts BR; Swearer SE
Glutathione peroxidase 4: a new player in neurodegeneration?
Mol Psychiatry Volume: 22 Page(s): 328 - 335
03/01/2017 Authors: Cardoso BR; Hare DJ; Bush AI; Roberts BR
CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord.
Sci Rep Volume: 7 Page(s): 42292
02/13/2017 Authors: Hilton JB; Mercer SW; Lim NKH; Faux NG; Buncic G; Beckman JS; Roberts BR; Donnelly PS; White AR; Crouch PJ
Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL).
J Alzheimers Dis Volume: 57 Page(s): 183 - 193
01/01/2017 Authors: Cardoso BR; Hare DJ; Bush AI; Li Q-X; Fowler CJ; Masters CL; Martins RN; Ganio K; Lothian A; Mukherjee S
Analysis of trace elements and metalloproteins in fractionated human brain samples using size exclusion inductively coupled mass spectrometry
Neuromethods Volume: 124 Page(s): 119 - 125
01/01/2017 Authors: Gunn AP; Roberts BR
Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid.
Acta Neuropathol Commun Volume: 4 Page(s): 119
11/14/2016 Authors: Roberts BR; Doecke JD; Rembach A; Yvenes LF; Fowler CJ; McLean CA; Lind M; Volitakis I; Masters CL; Bush AI
The Neurobiology and Age-Related Prevalence of the 4 Allele of Apolipoprotein E in Alzheimer's Disease Cohorts.
J Mol Neurosci Volume: 60 Page(s): 316 - 324
11/01/2016 Authors: Heffernan AL; Chidgey C; Peng P; Masters CL; Roberts BR
Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.
Chem Sci Volume: 7 Page(s): 6576
10/01/2016 Authors: Paul B; Hare DJ; Bishop DP; Paton C; Nguyen VT; Cole N; Niedwiecki MM; Andreozzi E; Vais A; Billings JL
Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex.
Neuroimage Volume: 137 Page(s): 124 - 131
08/15/2016 Authors: Hare DJ; Raven EP; Roberts BR; Bogeski M; Portbury SD; McLean CA; Masters CL; Connor JR; Bush AI; Crouch PJ
Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing.
Metallomics Volume: 8 Page(s): 628 - 632
06/01/2016 Authors: Hare DJ; Faux NG; Roberts BR; Volitakis I; Martins RN; Bush AI
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.
Neurobiol Dis Volume: 89 Page(s): 1 - 9
05/01/2016 Authors: Williams JR; Trias E; Beilby PR; Lopez NI; Labut EM; Bradford CS; Roberts BR; McAllum EJ; Crouch PJ; Rhoads TW
Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS.
J Vis Exp
04/13/2016 Authors: Lothian A; Roberts BR
Accurate biometal quantification per individual Caenorhabditis elegans.
Analyst Volume: 141 Page(s): 1434 - 1439
02/21/2016 Authors: Ganio K; James SA; Hare DJ; Roberts BR; McColl G
Profiling changes to natively-bound metals during Caenorhabditis elegans development.
RSC Adv Volume: 6 Page(s): 113689 - 113693
01/01/2016 Authors: Hare DJ; Roberts BR; McColl G
The Emerging Role of Metalloproteomics in Alzheimer's Disease Research.
Methods Mol Biol Volume: 1303 Page(s): 379 - 389
01/01/2016 Authors: Hare DJ; Rembach A; Roberts BR
High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease.
Curr Alzheimer Res Volume: 13 Page(s): 787 - 799
01/01/2016 Authors: Franois M; Fenech MF; Thomas P; Hor M; Rembach A; Martins RN; Rainey-Smith SR; Masters CL; Ames D; Rowe CC
Matrix metalloprotease processing of the prion protein
Volume: 10 Page(s): S41 - S42
01/01/2016 Authors: Lewis V; Johanssen VA; Roberts BR; Collins SJ
Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.
Chem Sci Volume: 6 Page(s): 6677
11/01/2015 Authors: Paul B; Hare DJ; Bishop DP; Paton C; Nguyen VT; Cole N; Niedzwiecki MM; Andreozzi E; Vais A; Billings JL
Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.
Chem Sci Volume: 6 Page(s): 5383 - 5393
10/01/2015 Authors: Paul B; Hare DJ; Bishop DP; Paton C; Nguyen VT; Cole N; Niedwiecki MM; Andreozzi E; Vais A; Billings JL
Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.
Neurobiol Dis Volume: 81 Page(s): 20 - 24
09/01/2015 Authors: McAllum EJ; Roberts BR; Hickey JL; Dang TN; Grubman A; Donnelly PS; Liddell JR; White AR; Crouch PJ
Selenium, selenoproteins and neurodegenerative diseases.
Metallomics Volume: 7 Page(s): 1213 - 1228
08/01/2015 Authors: Cardoso BR; Roberts BR; Bush AI; Hare DJ
Identification of proteins interacting with amyloid precursor protein for neurotoxicity and neuroprotection
Volume: 134 Page(s): 199 - 199
08/01/2015 Authors: Inampudi C; Jana M; Ciccotosto G; Plummer S; Roberts B; van den Heuvel C; Cappai R
Throwing light on neurodegeneration; small angle X-ray scattering studies on protein misfolding at the australian synchrotron
Volume: 134 Page(s): 129 - 129
08/01/2015 Authors: Curtain C; Kirby N; Roberts B; Ryan T
Defining how dopamine modulates alpha-synuclein oligomerisation
Volume: 134 Page(s): 128 - 129
08/01/2015 Authors: Connor A; Lothian A; Roberts B; Cappai R
Selenium as a potential biomarker for Alzheimer's disease
Volume: 134 Page(s): 348 - 349
08/01/2015 Authors: Cardoso B; Roberts B; Bush A; Hare D
Amyloid-beta remains a membrane peptide after cleavage. implications for secretion and kinetics of abeta turnover in human brain
Volume: 134 Page(s): 344 - 344
08/01/2015 Authors: Roberts B; Lind M; Rembach A; Ryan T; Wagen A; Mclean C; Barnham K; Li Q-X; Villemagne V; Masters C
Cu+ is a cofactor for ubiquitin conjugation and cellular protein degradation
Volume: 134 Page(s): 343 - 343
08/01/2015 Authors: Opazo C; Greenough M; Lim C; Lothian A; Roberts B; Luza S; Monahan B; Camakaris J; Bush A
FluphenazineHCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils.
Biochemistry Volume: 54 Page(s): 3831 - 3838
06/23/2015 Authors: Zlatic CO; Mao Y; Ryan TM; Mok Y-F; Roberts BR; Howlett GJ; Griffin MDW
Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans.
Chem Sci Volume: 6 Page(s): 2952 - 2962
05/01/2015 Authors: James SA; Roberts BR; Hare DJ; de Jonge MD; Birchall IE; Jenkins NL; Cherny RA; Bush AI; McColl G
Elucidating the role of matrix metalloproteases in prion protein proteolysis
Volume: 9 Page(s): S79 - S79
04/24/2015 Authors: Lewis V; Johanssen V; Lothian A; Roberts B; Crouch P; Collins S
The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro.
Stem Cell Res Ther Volume: 6 Page(s): 60
04/11/2015 Authors: Collins SJ; Tumpach C; Li Q-X; Lewis V; Ryan TM; Roberts B; Drew SC; Lawson VA; Haigh CL
Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation.
ACS Chem Neurosci Volume: 6 Page(s): 398 - 402
03/18/2015 Authors: Hare DJ; Doecke JD; Faux NG; Rembach A; Volitakis I; Fowler CJ; Grimm R; Doble PA; Cherny RA; Masters CL
Small angle X-ray scattering analysis of Cu(2+)-induced oligomers of the Alzheimer's amyloid peptide.
Metallomics Volume: 7 Page(s): 536 - 543
03/01/2015 Authors: Ryan TM; Kirby N; Mertens HDT; Roberts B; Barnham KJ; Cappai R; Pham CLL; Masters CL; Curtain CC
Stabilization of nontoxic A-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
J Neurosci Volume: 35 Page(s): 2871 - 2884
02/18/2015 Authors: Ryan TM; Roberts BR; McColl G; Hare DJ; Doble PA; Li Q-X; Lind M; Roberts AM; Mertens HDT; Kirby N
Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease.
Redox Biol Volume: 4 Page(s): 363 - 374
01/01/2015 Authors: Berggren KL; Chen J; Fox J; Miller J; Dodds L; Dugas B; Vargas L; Lothian A; McAllum E; Volitakis I
Traumatic brain injury induces elevation of Co in the human brain.
Metallomics Volume: 7 Page(s): 66 - 70
01/01/2015 Authors: Roberts BR; Hare DJ; McLean CA; Conquest A; Lind M; Li Q-X; Bush AI; Masters CL; Morganti-Kossmann M-C; Frugier T
Improved locomotor function and survival of mice with increased levels of mutant superoxide dismutase 1
Volume: 130 Page(s): 44 - 44
08/01/2014 Authors: Roberts BR; Lim NKH; McAllum EJ; Donnelly PS; Hare DJ; Doble PA; Turner BJ; Price KA; Lim SC; Paterson BM
Traumatic brain injury induces immediate cleavage of amyloid precursor protein in the human brain
Volume: 130 Page(s): 44 - 45
08/01/2014 Authors: Frugier T; McLean CA; Crack PJ; Roberts BR
Decreased serum zinc is an effect of ageing and not Alzheimer's disease.
Metallomics Volume: 6 Page(s): 1216 - 1219
07/01/2014 Authors: Rembach A; Hare DJ; Doecke JD; Burnham SC; Volitakis I; Fowler CJ; Cherny RA; McLean C; Grimm R; Martins R
Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.
J Neurosci Volume: 34 Page(s): 8021 - 8031
06/04/2014 Authors: Roberts BR; Lim NKH; McAllum EJ; Donnelly PS; Hare DJ; Doble PA; Turner BJ; Price KA; Lim SC; Paterson BM
Ceruloplasmin and -amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.
Free Radic Biol Med Volume: 69 Page(s): 331 - 337
04/01/2014 Authors: Ayton S; Zhang M; Roberts BR; Lam LQ; Lind M; McLean C; Bush AI; Frugier T; Crack PJ; Duce JA
Improving the metal content of mutant SOD1 as a therapeutic strategy for Amyotrophic Lateral Sclerosis
Volume: 19 Page(s): S694 - S694
03/01/2014 Authors: Mcallum E; Lim N; White A; Crouch PJ; Roberts BR; Hickey J; Paterson BM; Donnely P; Barhnam KJ; Williams J
Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease.
Alzheimers Dement Volume: 10 Page(s): 53 - 61
01/01/2014 Authors: Rembach A; Faux NG; Watt AD; Pertile KK; Rumble RL; Trounson BO; Fowler CJ; Roberts BR; Perez KA; Li Q-X
Guanidine hydrochloride denaturation of dopamine-induced -synuclein oligomers: a small-angle X-ray scattering study.
Proteins Volume: 82 Page(s): 10 - 21
01/01/2014 Authors: Pham CLL; Kirby N; Wood K; Ryan T; Roberts B; Sokolova A; Barnham KJ; Masters CL; Knott RB; Cappai R
An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
Chemical Science Volume: 5 Page(s): 2160 - 2169
01/01/2014 Authors: Hare DJ; Lei P; Ayton S; Roberts BR; Grimm R; George JL; Bishop DP; Beavis AD; Donovan SJ; McColl G
Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry.
Metallomics Volume: 5 Page(s): 1656 - 1662
12/01/2013 Authors: Hare DJ; Grubman A; Ryan TM; Lothian A; Liddell JR; Grimm R; Matsuda T; Doble PA; Cherny RA; Bush AI
Synthetic dityrosine-linked -amyloid dimers form stable, soluble, neurotoxic oligomers
Chemical Science Volume: 4 Page(s): 4449 - 4454
10/28/2013 Authors: Kok WM; Cottam JM; Ciccotosto GD; Miles LA; Karas JA; Scanlon DB; Roberts BR; Parker MW; Cappai R; Barnham KJ
Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes.
Biomark Med Volume: 7 Page(s): 641 - 662
08/01/2013 Authors: Rembach A; Ryan TM; Roberts BR; Doecke JD; Wilson WJ; Watt AD; Barnham KJ; Masters CL
The Role of A in Alzheimer's Disease
Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties Page(s): 263 - 293
01/27/2013 Authors: Ryan TM; Roberts BR; Streltsov VA; Nuttall SD; Masters CL
Decreased copper in Alzheimer's disease brain is predominantly in the soluble extractable fraction.
Int J Alzheimers Dis Volume: 2013 Page(s): 623241
01/01/2013 Authors: Rembach A; Hare DJ; Lind M; Fowler CJ; Cherny RA; McLean C; Bush AI; Masters CL; Roberts BR
Ammonium hydroxide treatment of A produces an aggregate free solution suitable for biophysical and cell culture characterization.
PeerJ Volume: 1 Page(s): e73
01/01/2013 Authors: Ryan TM; Caine J; Mertens HDT; Kirby N; Nigro J; Breheney K; Waddington LJ; Streltsov VA; Curtain C; Masters CL
Metalloproteomics: principles, challenges and applications to neurodegeneration.
Front Aging Neurosci Volume: 5 Page(s): 35
01/01/2013 Authors: Lothian A; Hare DJ; Grimm R; Ryan TM; Masters CL; Roberts BR
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
J Alzheimers Dis Volume: 34 Page(s): 171 - 182
01/01/2013 Authors: Rembach A; Doecke JD; Roberts BR; Watt AD; Faux NG; Volitakis I; Pertile KK; Rumble RL; Trounson BO; Fowler CJ
Utility of an improved model of amyloid-beta (A) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
Mol Neurodegener Volume: 7 Page(s): 57
11/21/2012 Authors: McColl G; Roberts BR; Pukala TL; Kenche VB; Roberts CM; Link CD; Ryan TM; Masters CL; Barnham KJ; Bush AI
Therapeutically increasing mutant SOD1 metallation status attenuates disease symptoms in an ALS mouse model
Volume: 123 Page(s): 16 - 16
10/01/2012 Authors: Lim N; Roberts BR; Donnelly PS; Lim S; Beckman JS; Barnham KJ; Li Q; White AR; Crouch PJ
Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide A(1-42).
J Biol Chem Volume: 287 Page(s): 16947 - 16954
05/11/2012 Authors: Ryan TM; Friedhuber A; Lind M; Howlett GJ; Masters C; Roberts BR
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
J Exp Med Volume: 209 Page(s): 837 - 854
04/09/2012 Authors: Hung LW; Villemagne VL; Cheng L; Sherratt NA; Ayton S; White AR; Crouch PJ; Lim S; Leong SL; Wilkins S
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
Nat Med Volume: 18 Page(s): 291 - 295
01/29/2012 Authors: Lei P; Ayton S; Finkelstein DI; Spoerri L; Ciccotosto GD; Wright DK; Wong BXW; Adlard PA; Cherny RA; Lam LQ
Rapid generation of dityrosine cross-linked A oligomers via Cu-redox cycling.
Methods Mol Biol Volume: 849 Page(s): 3 - 10
01/01/2012 Authors: Gunn AP; Roberts BR; Bush AI
The role of metallobiology and amyloid- peptides in Alzheimer's disease.
J Neurochem Volume: 120 Suppl 1 Page(s): 149 - 166
01/01/2012 Authors: Roberts BR; Ryan TM; Bush AI; Masters CL; Duce JA
Copper promotes the trafficking of the amyloid precursor protein.
J Biol Chem Volume: 286 Page(s): 8252 - 8262
03/11/2011 Authors: Acevedo KM; Hung YH; Dalziel AH; Li Q-X; Laughton K; Wikhe K; Rembach A; Roberts B; Masters CL; Bush AI
Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease.
ACS Chem Neurosci Volume: 1 Page(s): 720 - 727
11/17/2010 Authors: Lawson VA; Haigh CL; Roberts B; Kenche VB; Klemm HMJ; Masters CL; Collins SJ; Barnham KJ; Drew SC
Cu,Zn-superoxide dismutase increases toxicity of mutant and zinc-deficient superoxide dismutase by enhancing protein stability.
J Biol Chem Volume: 285 Page(s): 33885 - 33897
10/29/2010 Authors: Garner MA; Ricart KC; Roberts BR; Bomben VC; Basso M; Ye Y; Sahawneh J; Franco MC; Beckman JS; Estvez AG
Role of Metals in Alzheimer Disease
Protein Misfolding Diseases: Current and Emerging Principles and Therapies Page(s): 543 - 558
07/02/2010 Authors: Roberts BR; Bush AI
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.
J Biol Chem Volume: 284 Page(s): 22697 - 22702
08/21/2009 Authors: McColl G; Roberts BR; Gunn AP; Perez KA; Tew DJ; Masters CL; Barnham KJ; Cherny RA; Bush AI
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
J Mol Biol Volume: 373 Page(s): 877 - 890
11/02/2007 Authors: Roberts BR; Tainer JA; Getzoff ED; Malencik DA; Anderson SR; Bomben VC; Meyers KR; Karplus PA; Beckman JS
Why are ALS mutations to SOD dominate? Cu, ZnSOD stabilization of zinc-deficient SOD as a heterodimer
Volume: 41 Page(s): S167 - S168
01/01/2006 Authors: Roberts BR; Malencik D; Beckman JS
Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.
Protein Sci Volume: 14 Page(s): 2414 - 2420
09/01/2005 Authors: Roberts BR; Wood ZA; Jnsson TJ; Poole LB; Karplus PA
It takes two to tango - Structural insight into the motor neuron toxicity of zinc deficient superoxide dismutase
Volume: 39 Page(s): S63 - S64
01/01/2005 Authors: Roberts B; Tainer J; Estevez A; Karplus A; Beckman J
Peroxynitrite and nitration of green fluorescent protein
Volume: 35 Page(s): S109 - S110
01/01/2003 Authors: Roberts BR; Beckman JS

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Blaine Roberts

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