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Profile

Bo Liang

  • Department of Biochemistry
    Associate Professor
  • (404) 727-8287
  • bo.liang@emory.edu
  • Lab website
  • Google Scholar
  • PubMed
  • Emory University
    Department of Biochemistry
    1510 Clifton Road NE, RM G247
Head shot of Bo Liang

Overview

The principal goal of our research is to scrutinize high-resolution structural details and to understand the molecular mechanisms of large assemblies, including ribonucleoprotein complexes and membrane proteins using integrated approaches of cryo-EM, x-ray crystallography and fluorescence light microscopy.

Academic Appointment

  • Associate Professor, Department of Biochemistry, Emory University School of Medicine

Education

Degrees

  • PhD from Florida State University
  • Bachelor of Science from University of Science and Technology of China
  • Bachelor of Engineering from University of Science and Technology of China

Research

Publications

  • SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

    03/26/2025 Authors: Cooper GW; Lee BP; Kim WJ; Su Y; Chen VZ; Salas E; Yang X; Lintner RE; Piccioni F; Giacomelli AO
  • Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis.
    Res Sq
    01/29/2025 Authors: Kim JS; Chen Z; Garcia SAE; Buhlheller C; Richards SJ; Chen T; Wu J; Bruntz RC; Gilliam ME; Yamauchi M
  • Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.
    Virology Volume: 600 Page(s): 110255
    12/01/2024 Authors: Oo A; Chen Z; Cao D; Cho Y-J; Liang B; Schinazi RF; Kim B
  • In vitro higher-order oligomeric assembly of the respiratory syncytial virus M2-1 protein with longer RNAs.
    J Virol Volume: 98 Page(s): e0104624
    08/20/2024 Authors: Gao Y; Raghavan A; Espinosa Garcia SA; Deng B; Hurtado de Mendoza D; Liang B
  • Structures of the promoter-bound respiratory syncytial virus polymerase.
    Nature Volume: 625 Page(s): 611 - 617
    01/01/2024 Authors: Cao D; Gao Y; Chen Z; Gooneratne I; Roesler C; Mera C; D'Cunha P; Antonova A; Katta D; Romanelli S
  • Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2.
    J Med Virol Volume: 95 Page(s): e29163
    10/01/2023 Authors: Ahn H; Calderon BM; Fan X; Gao Y; Horgan NL; Jiang N; Blohm DS; Hossain J; Rayyan NWK; Osman SH
  • In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase.
    Microorganisms Volume: 11
    06/18/2023 Authors: Xu E; Park S; Calderon J; Cao D; Liang B
  • PEBAT, an Intriguing Neurodegenerative Tubulinopathy Caused by a Novel Homozygous Variant in TBCD: A Case Series and Literature Review.
    Pediatr Neurol Volume: 139 Page(s): 59 - 64
    02/01/2023 Authors: Ocampo-Chih C; Dennis H; Lall N; Pham N; Liang B; Verma S; Neira Fresneda J
  • Optimal Conditions for In Vitro Assembly of Respiratory Syncytial Virus Nucleocapsid-like Particles.
    Viruses Volume: 15
    01/25/2023 Authors: Gao Y; Raghavan A; Deng B; Lee J; Liang B
  • An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice.
    J Infect Dis Volume: 227 Page(s): 50 - 60
    12/28/2022 Authors: Roe MK; Perez MA; Hsiao H-M; Lapp SA; Sun H-Y; Jadhao S; Young AR; Batista YS; Reed RC; Taz A
  • Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase.
    Viruses Volume: 15
    12/23/2022 Authors: Cao D; Gooneratne I; Mera C; Vy J; Royal M; Huang B; Park Y; Manjunath A; Liang B
  • Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus.
    Sci Rep Volume: 12 Page(s): 16806
    10/07/2022 Authors: Wu W; Kim JS; Bailey AO; Russell WK; Richards SJ; Chen T; Chen T; Chen Z; Liang B; Yamauchi M
  • Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
    Bioorg Med Chem Volume: 45 Page(s): 116324
    09/01/2021 Authors: Yang X; Fan D; Troha AH; Ahn HM; Qian K; Liang B; Du Y; Fu H; Ivanov AA
  • Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus.
    J Vis Exp
    07/27/2021 Authors: Gao Y; Ogilvie C; Raghavan A; Von Hoffmann C; Liang B
  • The basis of a more contagious 501Y.V1 variant of SARS-CoV-2.
    Cell Res Volume: 31 Page(s): 720 - 722
    06/01/2021 Authors: Liu H; Zhang Q; Wei P; Chen Z; Aviszus K; Yang J; Downing W; Jiang C; Liang B; Reynoso L
  • Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes.
    Viruses Volume: 13
    05/05/2021 Authors: Cao D; Gao Y; Liang B
  • Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
    Microorganisms Volume: 9
    04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L
  • Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations.
    STAR Protoc Volume: 2 Page(s): 100315
    03/19/2021 Authors: Gao Y; Cao D; Pawnikar S; Akhter S; Miao Y; Liang B
  • Cryo-Electron Microscopy Structures of the Pneumoviridae Polymerases.
    Viral Immunol Volume: 34 Page(s): 18 - 26
    01/01/2021 Authors: Cao D; Liang B
  • Repurposing Nucleoside Analogs for Human Coronaviruses.
    Antimicrob Agents Chemother Volume: 65
    12/16/2020 Authors: Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T
  • In Vitro Primer-Based RNA Elongation and Promoter Fine Mapping of the Respiratory Syncytial Virus.
    J Virol Volume: 95
    12/09/2020 Authors: Cao D; Gao Y; Roesler C; Rice S; D'Cunha P; Zhuang L; Slack J; Antonova A; Romanelli S; Liang B
  • Structures of the Mononegavirales Polymerases.
    J Virol Volume: 94
    10/27/2020 Authors: Liang B
  • Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA.
    Structure Volume: 28 Page(s): 979 - 990.e4
    09/01/2020 Authors: Gao Y; Cao D; Pawnikar S; John KP; Ahn HM; Hill S; Ha JM; Parikh P; Ogilvie C; Swain A
  • Cryo-EM structure of the respiratory syncytial virus RNA polymerase.
    Nat Commun Volume: 11 Page(s): 368
    01/17/2020 Authors: Cao D; Gao Y; Roesler C; Rice S; D'Cunha P; Zhuang L; Slack J; Domke M; Antonova A; Romanelli S
  • In vitro trackable assembly of RNA-specific nucleocapsids of the respiratory syncytial virus.
    J Biol Chem Volume: 295 Page(s): 883 - 895
    01/17/2020 Authors: Gao Y; Cao D; Ahn HM; Swain A; Hill S; Ogilvie C; Kurien M; Rahmatullah T; Liang B
  • Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.
    Cell Rep Volume: 30 Page(s): 53 - 60.e5
    01/07/2020 Authors: Jenni S; Bloyet L-M; Diaz-Avalos R; Liang B; Whelan SPJ; Grigorieff N; Harrison SC
  • A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity.
    Virology Volume: 536 Page(s): 78 - 90
    10/01/2019 Authors: Trost JF; Wang W; Liang B; Galloway SE; Agbogu E; Byrd-Leotis L; Steinhauer DA
  • Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning.
    Cell Rep Volume: 28 Page(s): 1167 - 1181.e7
    07/30/2019 Authors: Wu J; Kung J; Dong J; Chang L; Xie C; Habib A; Hawes S; Yang N; Chen V; Liu Z
  • Cryo-EM structure of TRPC5 at 2.8- resolution reveals unique and conserved structural elements essential for channel function.
    Sci Adv Volume: 5 Page(s): eaaw7935
    07/01/2019 Authors: Duan J; Li J; Chen G-L; Ge Y; Liu J; Xie K; Peng X; Zhou W; Zhong J; Zhang Y
  • An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity.
    J Virol Volume: 91
    01/01/2017 Authors: Morin B; Liang B; Gardner E; Ross RA; Whelan SPJ
  • Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.
    Sci Signal Volume: 9 Page(s): ra77
    08/02/2016 Authors: Kahle KT; Flores B; Bharucha-Goebel D; Zhang J; Donkervoort S; Hegde M; Hussain G; Duran D; Liang B; Sun D
  • Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
    Cell Volume: 162 Page(s): 314 - 327
    07/16/2015 Authors: Liang B; Li Z; Jenni S; Rahmeh AA; Morin BM; Grant T; Grigorieff N; Harrison SC; Whelan SPJ
  • Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia.
    Front Cell Neurosci Volume: 9 Page(s): 386
    01/01/2015 Authors: Merner ND; Chandler MR; Bourassa C; Liang B; Khanna AR; Dion P; Rouleau GA; Kahle KT
  • Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.
    EMBO Rep Volume: 15 Page(s): 766 - 774
    07/01/2014 Authors: Kahle KT; Merner ND; Friedel P; Silayeva L; Liang B; Khanna A; Shang Y; Lachance-Touchette P; Bourassa C; Levert A
  • Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 14628 - 14633
    09/04/2012 Authors: Rahmeh AA; Morin B; Schenk AD; Liang B; Heinrich BS; Brusic V; Walz T; Whelan SPJ
  • Structures of ribonucleoprotein particle modification enzymes.
    Q Rev Biophys Volume: 44 Page(s): 95 - 122
    02/01/2011 Authors: Liang B; Li H
  • Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide.
    RNA Volume: 17 Page(s): 244 - 250
    02/01/2011 Authors: Zhou J; Liang B; Li H
  • Molecular architecture of the vesicular stomatitis virus RNA polymerase.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 20075 - 20080
    11/16/2010 Authors: Rahmeh AA; Schenk AD; Danek EI; Kranzusch PJ; Liang B; Walz T; Whelan SPJ
  • Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study.
    J Mol Biol Volume: 401 Page(s): 690 - 695
    09/03/2010 Authors: Zhou J; Lv C; Liang B; Chen M; Yang W; Li H
  • Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase.
    Biochemistry Volume: 49 Page(s): 6276 - 6281
    07/27/2010 Authors: Zhou J; Liang B; Li H
  • Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA.
    Nat Struct Mol Biol Volume: 16 Page(s): 740 - 746
    07/01/2009 Authors: Liang B; Zhou J; Kahen E; Terns RM; Terns MP; Li H
  • Long-distance placement of substrate RNA by H/ACA proteins.
    RNA Volume: 14 Page(s): 2086 - 2094
    10/01/2008 Authors: Liang B; Kahen EJ; Calvin K; Zhou J; Blanco M; Li H
  • Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex.
    Nat Struct Mol Biol Volume: 14 Page(s): 1189 - 1195
    12/01/2007 Authors: Liang B; Xue S; Terns RM; Terns MP; Li H
  • Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.
    Mol Cell Volume: 21 Page(s): 249 - 260
    01/20/2006 Authors: Rashid R; Liang B; Baker DL; Youssef OA; He Y; Phipps K; Terns RM; Terns MP; Li H
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