Baek Kim

Department of Pediatrics
Professor

baek.kim@emory.edu

Academic Appointment

Acting Professor of Pediatrics, Center for Drug Discovery, Emory University
Visiting Professor of Nanotechnology, Kyung-Hee University

Education

Degrees

PhD from University of Arizona
M.S. from Yonsei University
B. Pharm. from School of Pharmacy, Kyung-Hee University

Research

Focus

The long-term research focus in my laboratory is to elucidate molecular mechanisms involved in HIV genomic hypermutability, which enables HIV to evolve and escape from various selective pressures including anti-retroviral therapy, during the course of infection. Our research path starts from biochemical and enzymological understanding of HIV-1 reverse transcriptase, which provides us with hypotheses which are eventually tested in tissue culture based systems, or possibly in animal models.

Publications

The immunogenicity and protection efficacy evaluation of mRNA vaccine candidate for severe fever with thrombocytopenia syndrome in mice.
PLoS Negl Trop Dis Volume: 19 Page(s): e0012999
04/01/2025 Authors: Jeong D-E; Yoon J; Kim B; Kang J-G
NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.
Nat Commun Volume: 15 Page(s): 10737
12/30/2024 Authors: Reddy T; Puri A; Guzman-Rojas L; Thomas C; Qian W; Zhou J; Zhao H; Mahboubi B; Oo A; Cho Y-J
Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.
Virology Volume: 600 Page(s): 110255
12/01/2024 Authors: Oo A; Chen Z; Cao D; Cho Y-J; Liang B; Schinazi RF; Kim B
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
mBio Volume: 15 Page(s): e0046524
11/13/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P
Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
mBio Volume: 15 Page(s): e0195824
09/11/2024 Authors: Bulnes-Ramos A; Schott K; Rabinowitz J; Luchsinger C; Bertelli C; Miyagi E; Yu CH; Persaud M; Shepard C; Knig R
NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome.
Blood Volume: 144 Page(s): 283 - 295
07/18/2024 Authors: Sobh A; Encinas E; Patel A; Surapaneni G; Bonilla E; Kaestner C; Poullard J; Clerio M; Vasan K; Freeman T
E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network.
Cancer Res Commun Volume: 4 Page(s): 1863 - 1880
07/01/2024 Authors: Poliakov Turan M; Riedo R; Medo M; Pozzato C; Friese-Hamim M; Koch JP; Coggins SA; Li Q; Kim B; Albers J
The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity.
Nat Commun Volume: 15 Page(s): 4667
05/31/2024 Authors: Prasad CB; Oo A; Liu Y; Qiu Z; Zhong Y; Li N; Singh D; Xin X; Cho Y-J; Li Z
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Blood Volume: 143 Page(s): 1953 - 1964
05/09/2024 Authors: Abdelrazak Morsy MH; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients.
NAR Cancer Volume: 6 Page(s): zcae007
03/01/2024 Authors: Daddacha W; Monroe D; Schlafstein AJ; Withers AE; Thompson EB; Danelia D; Luong NC; Sesay F; Rath SK; Usoro ER
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
Nucleic Acids Res Volume: 52 Page(s): 1207 - 1225
02/09/2024 Authors: Xu P; Yang T; Kundnani DL; Sun M; Marsili S; Gombolay AL; Jeon Y; Newnam G; Balachander S; Bazzani V
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
bioRxiv
01/26/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Blood Volume: 143 Page(s): 1953 - 1964
01/18/2024 Authors: Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Mol Ther Volume: 32 Page(s): 124 - 139
01/03/2024 Authors: Valeri E; Unali G; Piras F; Abou-Alezz M; Pais G; Benedicenti F; Lidonnici MR; Cuccovillo I; Castiglioni I; Arvalo S
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
mBio Volume: 14 Page(s): e0225223
10/31/2023 Authors: Schssler M; Schott K; Fuchs NV; Oo A; Zahadi M; Rauch P; Kim B; Knig R
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutires syndrome SAMHD1 dNTPase ortholog.
J Biol Chem Volume: 299 Page(s): 105148
09/01/2023 Authors: Maehigashi T; Lim C; Wade LR; Bowen NE; Knecht KM; Alvarez NN; Kelly WG; Schinazi RF; Kim D-H; Xiong Y
Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
J Biol Chem Volume: 299 Page(s): 104984
08/01/2023 Authors: Bowen NE; Tao S; Cho Y-J; Schinazi RF; Kim B
ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.
Nat Commun Volume: 14 Page(s): 3618
06/19/2023 Authors: Menolfi D; Lee BJ; Zhang H; Jiang W; Bowen NE; Wang Y; Zhao J; Holmes A; Gershik S; Rabadan R
The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity.
Res Sq
05/02/2023 Authors: Prasad CB; Oo A; Qiu Z; Li N; Singh D; Xin X; Cho Y-J; Li Z; Zhang X; Yan C
The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
mBio Volume: 14 Page(s): e0356022
02/28/2023 Authors: Singer MR; Dinh T; Levintov L; Annamalai AS; Rey JS; Briganti L; Cook NJ; Pye VE; Taylor IA; Kim K
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
J Intern Med Volume: 292 Page(s): 925 - 940
12/01/2022 Authors: Jdersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzn S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
Nat Commun Volume: 13 Page(s): 6707
11/07/2022 Authors: Kapoor-Vazirani P; Rath SK; Liu X; Shu Z; Bowen NE; Chen Y; Haji-Seyed-Javadi R; Daddacha W; Minten EV; Danelia D
Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis.
Viruses Volume: 14
07/26/2022 Authors: Bowen NE; Oo A; Kim B
MESH1 knockdown triggers proliferation arrest through TAZ repression.
Cell Death Dis Volume: 13 Page(s): 221
03/10/2022 Authors: Sun T; Ding C-KC; Zhang Y; Zhang Y; Lin C-C; Wu J; Setayeshpour Y; Coggins S; Shepard C; Macias E
Elimination of Aicardi-Goutires syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
J Biol Chem Volume: 298 Page(s): 101635
03/01/2022 Authors: Oo A; Zandi K; Shepard C; Bassit LC; Musall K; Goh SL; Cho Y-J; Kim D-H; Schinazi RF; Kim B
Nucleotide Analogues Bearing a C2' or C3'-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors.
Molecules Volume: 27
01/17/2022 Authors: Manchoju A; Zelli R; Wang G; Eymard C; Oo A; Nemer M; Prvost M; Kim B; Guindon Y
SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
J Immunol Volume: 208 Page(s): 444 - 453
01/15/2022 Authors: Barrett B; Nguyen DH; Xu J; Guo K; Shetty S; Jones ST; Mickens KL; Shepard C; Roers A; Behrendt R
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
J Biol Chem Volume: 297 Page(s): 101170
10/01/2021 Authors: Bowen NE; Temple J; Shepard C; Oo A; Arizaga F; Kapoor-Vazirani P; Persaud M; Yu CH; Kim D-H; Schinazi RF
Distinct Antiretroviral Mechanisms Elicited by a Viral Mutagen.
J Mol Biol Volume: 433 Page(s): 167111
09/03/2021 Authors: Roth M; McDaniel YZ; Daly MB; Talledge N; Greggs WM; Patterson SE; Kim B; Mansky LM
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment.
Cancers (Basel) Volume: 13
08/20/2021 Authors: Bothou C; Sharma A; Oo A; Kim B; Perge P; Igaz P; Ronchi CL; Shapiro I; Hantel C
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.
Nat Commun Volume: 12 Page(s): 4582
07/28/2021 Authors: Martinat C; Cormier A; Tobaly-Tapiero J; Palmic N; Casartelli N; Mahboubi B; Coggins SA; Buchrieser J; Persaud M; Diaz-Griffero F
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
PLoS Pathog Volume: 17 Page(s): e1009671
07/01/2021 Authors: Maehigashi T; Ahn S; Kim U-I; Lindenberger J; Oo A; Koneru PC; Mahboubi B; Engelman AN; Kvaratskhelia M; Kim K
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
Microorganisms Volume: 9
04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L
In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer.
Sci Rep Volume: 11 Page(s): 8042
04/13/2021 Authors: Lin ZP; Al Zouabi NN; Xu ML; Bowen NE; Wu TL; Lavi ES; Huang PH; Zhu Y-L; Kim B; Ratner ES
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Nat Commun Volume: 12 Page(s): 731
02/02/2021 Authors: Yu CH; Bhattacharya A; Persaud M; Taylor AB; Wang Z; Bulnes-Ramos A; Xu J; Selyutina A; Martinez-Lopez A; Cano K
Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii.
iScience Volume: 24 Page(s): 102005
01/22/2021 Authors: El-Sayed WMM; Gombolay AL; Xu P; Yang T; Jeon Y; Balachander S; Newnam G; Tao S; Bowen NE; Brna T
Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma.
Front Oncol Volume: 11 Page(s): 725137
01/01/2021 Authors: Ravi D; Beheshti A; Abermil N; Lansigan F; Kinlaw W; Matthan NR; Mokhtar M; Passero FC; Puliti P; David KA
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
Repurposing Nucleoside Analogs for Human Coronaviruses.
Antimicrob Agents Chemother Volume: 65
12/16/2020 Authors: Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
J Biol Chem Volume: 295 Page(s): 16975 - 16986
12/11/2020 Authors: Coggins SA; Kim D-H; Schinazi RF; Desrosier RC; Kim B
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
J Biol Chem Volume: 295 Page(s): 16975 - 16986
12/11/2020 Authors: Coggins SA; Kim D-H; Schinazi RF; Desrosier RC; Kim B
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
Viruses Volume: 12
10/31/2020 Authors: Cox A; Schmierer J; D'Angelo J; Smith A; Levenson D; Treanor J; Kim B; Dewhurst S
Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery.
J Biol Chem Volume: 295 Page(s): 13432 - 13443
09/25/2020 Authors: Coggins SA; Mahboubi B; Schinazi RF; Kim B
Tetraspanin CD81 regulates HSV-1 infection.
Med Microbiol Immunol Volume: 209 Page(s): 489 - 498
08/01/2020 Authors: Benayas B; Sastre I; Lpez-Martn S; Oo A; Kim B; Bullido MJ; Aldudo J; Yez-M M
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer.
Nat Commun Volume: 11 Page(s): 3214
06/25/2020 Authors: Gandhi M; Gro M; Holler JM; Coggins SA; Patil N; Leupold JH; Munschauer M; Schenone M; Hartigan CR; Allgayer H
A metabolomics discovery profiling approach identifies an E2F1-associated purine synthesis pathway as a major component of the MET-DNA damage response network.
Volume: 80 Page(s): 26 - 26
06/01/2020 Authors: Poliakova M; Medo M; Koch J; Coggins S; Kim B; Aebersold DM; Zamboni N; Medova M; Zimmer Y
Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.
Nat Commun Volume: 11 Page(s): 2447
05/15/2020 Authors: Balachander S; Gombolay AL; Yang T; Xu P; Newnam G; Keskin H; El-Sayed WMM; Bryksin AV; Tao S; Bowen NE
SAMHD1 Functions and Human Diseases.
Viruses Volume: 12
03/31/2020 Authors: Coggins SA; Mahboubi B; Schinazi RF; Kim B
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
EMBO Mol Med Volume: 12 Page(s): e10419
03/06/2020 Authors: Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
Nucleic Acids Res Volume: 48 Page(s): 1886 - 1904
02/28/2020 Authors: Basbous J; Aze A; Chaloin L; Lebdy R; Hodroj D; Ribeyre C; Larroque M; Shepard C; Kim B; Pruvost A
Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore.
Neuro Oncol Volume: 22 Page(s): 216 - 228
02/20/2020 Authors: Lim YC; Ensbey KS; Offenhuser C; D'souza RCJ; Cullen JK; Stringer BW; Quek H; Bruce ZC; Kijas A; Cianfanelli V
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
J Biol Chem Volume: 295 Page(s): 1575 - 1586
02/07/2020 Authors: Qin Z; Bonifati S; St Gelais C; Li T-W; Kim S-H; Antonucci JM; Mahboubi B; Yount JS; Xiong Y; Kim B
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
J Biol Chem Volume: 295 Page(s): 1575 - 1586
02/07/2020 Authors: Qin Z; Bonifati S; St Gelais C; Li T-W; Kim S-H; Antonucci JM; Mahboubi B; Yount JS; Xiong Y; Kim B
Viral protein X reduces the incorporation of mutagenic noncanonical rNTPs during lentivirus reverse transcription in macrophages.
J Biol Chem Volume: 295 Page(s): 657 - 666
01/10/2020 Authors: Oo A; Kim D-H; Schinazi RF; Kim B
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
Nat Commun Volume: 10 Page(s): 5177
11/15/2019 Authors: Zurlo G; Liu X; Takada M; Fan C; Simon JM; Ptacek TS; Rodriguez J; von Kriegsheim A; Liu J; Locasale JW
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers.
Cell Death Differ Volume: 26 Page(s): 2223 - 2236
11/01/2019 Authors: Siddiqui A; Gollavilli PN; Schwab A; Vazakidou ME; Ersan PG; Ramakrishnan M; Pluim D; Coggins S; Saatci O; Annaratone L
Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation.
Virology Volume: 537 Page(s): 36 - 44
11/01/2019 Authors: Coggins SA; Holler JM; Kimata JT; Kim D-H; Schinazi RF; Kim B
Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages.
Retrovirology Volume: 16 Page(s): 29
10/26/2019 Authors: Shepard C; Xu J; Holler J; Kim D-H; Mansky LM; Schinazi RF; Kim B
Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.
Viruses Volume: 11
10/10/2019 Authors: Rodriguez L; Blanco-Lobo P; Reilly EC; Maehigashi T; Nogales A; Smith A; Topham DJ; Dewhurst S; Kim B; Martnez-Sobrido L
Repurposing Agents Results in Selective Death Induction of HIV-1 Infected Myeloid Reservoirs
Volume: 25 Page(s): S15 - S15
10/01/2019 Authors: Gavegnano C; Shephard C; Holler J; Kim B
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2).
Clin Cancer Res Volume: 25 Page(s): 4480 - 4492
07/15/2019 Authors: Mazzu YZ; Armenia J; Chakraborty G; Yoshikawa Y; Coggins SA; Nandakumar S; Gerke TA; Pomerantz MM; Qiu X; Zhao H
Selective death induction of HIV-1 infected myeloid reservoirs
Volume: 22 Page(s): 22 - 22
07/01/2019 Authors: Gavegnano C; Shephard C; Holler J; Coggins S; Kim B
Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro.
Sci Rep Volume: 9 Page(s): 8682
06/18/2019 Authors: Jung E; Nam S; Oh H; Jun S; Ro H-J; Kim B; Kim M; Go YY
The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.
Virology Volume: 531 Page(s): 260 - 268
05/01/2019 Authors: Buffone C; Kutzner J; Opp S; Martinez-Lopez A; Selyutina A; Coggings SA; Studdard LR; Ding L; Kim B; Spearman P
Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.
J Biol Chem Volume: 293 Page(s): 16402 - 16412
10/19/2018 Authors: Mereby SA; Maehigashi T; Holler JM; Kim D-H; Schinazi RF; Kim B
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
J Virol Volume: 92
10/15/2018 Authors: Osei Kuffour E; Schott K; Jaguva Vasudevan AA; Holler J; Schulz WA; Lang PA; Lang KS; Kim B; Hussinger D; Knig R
Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages.
Retrovirology Volume: 15 Page(s): 69
10/13/2018 Authors: Mahboubi B; Gavegnano C; Kim D-H; Schinazi RF; Kim B
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun Volume: 9 Page(s): 3872
09/24/2018 Authors: Gustafsson NMS; Frnegrdh K; Bonagas N; Ninou AH; Groth P; Wiita E; Jnsson M; Hallberg K; Lehto J; Pennisi R
SAMHD1 deficient human monocytes autonomously trigger type I interferon.
Mol Immunol Volume: 101 Page(s): 450 - 460
09/01/2018 Authors: Martinez-Lopez A; Martin-Fernandez M; Buta S; Kim B; Bogunovic D; Diaz-Griffero F
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
Elife Volume: 7
08/22/2018 Authors: Kueck T; Cassella E; Holler J; Kim B; Bieniasz PD
Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.
Cell Rep Volume: 24 Page(s): 815 - 823
07/24/2018 Authors: Wang Z; Bhattacharya A; White T; Buffone C; McCabe A; Nguyen LA; Shepard CN; Pardo S; Kim B; Weintraub ST
Targeting poor-prognosis subtypes of prostate cancer by inhibition of DNA repair gene ribonucleotide reductase small subunit M2
Volume: 78
07/01/2018 Authors: Mazzu YZ; Armenia J; Chakraborty G; Yoshikawa Y; Gerke TA; Coggins SAA; Qiu X; Atiq M; Stopsack KH; Lee G-SM
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55 holoenzymes during mitotic exit.
Nat Commun Volume: 9 Page(s): 2227
06/08/2018 Authors: Schott K; Fuchs NV; Derua R; Mahboubi B; Schnellbcher E; Seifried J; Tondera C; Schmitz H; Shepard C; Brandariz-Nuez A
SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Proc Natl Acad Sci U S A Volume: 115 Page(s): 4921 - 4926
05/08/2018 Authors: Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B
Targeting a Novel Function for SAMHD1 in DNA Repair for Radiation Therapy and PARP Inhibition
Volume: 127 Page(s): S192 - S193
04/01/2018 Authors: Yu D; Daddacha W; Koyen A; Bastien A; Head P; Dhere V; Nabeta G; Connolly E; Werner E; Madden M
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
J Virol Volume: 92
03/15/2018 Authors: St Gelais C; Kim SH; Maksimova VV; Buzovetsky O; Knecht KM; Shepard C; Kim B; Xiong Y; Wu L
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Blood Cancer J Volume: 8 Page(s): 11
01/19/2018 Authors: Johansson P; Klein-Hitpass L; Choidas A; Habenberger P; Mahboubi B; Kim B; Bergmann A; Scholtysik R; Brauser M; Lollies A
A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.
Sci Rep Volume: 8 Page(s): 84
01/08/2018 Authors: Oh C; Ryoo J; Park K; Kim B; Daly MB; Cho D; Ahn K
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection.
Pathog Immun Volume: 3 Page(s): 197 - 223
01/01/2018 Authors: Plitnik T; Sharkey ME; Mahboubi B; Kim B; Stevenson M
Correction to: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Mob DNA Volume: 9 Page(s): 16
01/01/2018 Authors: Herrmann A; Wittmann S; Thomas D; Shepard CN; Kim B; Ferreirs N; Gramberg T
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Mob DNA Volume: 9 Page(s): 11
01/01/2018 Authors: Herrmann A; Wittmann S; Thomas D; Shepard CN; Kim B; Ferreirs N; Gramberg T
p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.
J Virol Volume: 91
12/01/2017 Authors: Valle-Casuso JC; Allouch A; David A; Lenzi GM; Studdard L; Barr-Sinoussi F; Mller-Trutwin M; Kim B; Pancino G; Sez-Cirin A
CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.
Nat Microbiol Volume: 2 Page(s): 1513 - 1522
11/01/2017 Authors: Rocha-Perugini V; Surez H; lvarez S; Lpez-Martn S; Lenzi GM; Vences-Cataln F; Levy S; Kim B; Muoz-Fernndez MA; Snchez-Madrid F
SAMHD1 Promotes DNA End Resection to Facilitate DNA Double-Strand Break Repair by Homologous Recombination
Volume: 58 Page(s): S84 - S84
09/01/2017 Authors: Yu DS; Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ
A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase is dispensable for HIV-1 infection in dividing and nondividing cells.
J Biol Chem Volume: 292 Page(s): 14016 - 14025
08/25/2017 Authors: Goetze RW; Kim D-H; Schinazi RF; Kim B
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Cell Rep Volume: 20 Page(s): 1921 - 1935
08/22/2017 Authors: Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ; Daly MB
Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.
Oncogenesis Volume: 6 Page(s): e349
06/12/2017 Authors: Hafez AY; Messinger JE; McFadden K; Fenyofalvi G; Shepard CN; Lenzi GM; Kim B; Luftig MA
A SAMHD1 mutation associated with Aicardi-Goutires syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.
Hum Mutat Volume: 38 Page(s): 658 - 668
06/01/2017 Authors: White TE; Brandariz-Nuez A; Martinez-Lopez A; Knowlton C; Lenzi G; Kim B; Ivanov D; Diaz-Griffero F
The small-molecule 3G11 inhibits HIV-1 reverse transcription.
Chem Biol Drug Des Volume: 89 Page(s): 608 - 618
04/01/2017 Authors: Opp S; Fricke T; Shepard C; Kovalskyy D; Bhattacharya A; Herkules F; Ivanov DN; Kim B; Valle-Casuso J; Diaz-Griffero F
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Proc Natl Acad Sci U S A Volume: 114 Page(s): 2729 - 2734
03/07/2017 Authors: Baldauf H-M; Stegmann L; Schwarz S-M; Ambiel I; Trotard M; Martin M; Burggraf M; Lenzi GM; Lejk H; Pan X
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
EMBO J Volume: 36 Page(s): 604 - 616
03/01/2017 Authors: Mlcochova P; Sutherland KA; Watters SA; Bertoli C; de Bruin RA; Rehwinkel J; Neil SJ; Lenzi GM; Kim B; Khwaja A
A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
J Biol Chem Volume: 292 Page(s): 1068 - 1080
01/20/2017 Authors: Bloch N; Glsker S; Sitaram P; Hofmann H; Shepard CN; Schultz ML; Kim B; Landau NR
Substrates and Inhibitors of SAMHD1.
PLoS One Volume: 12 Page(s): e0169052
01/01/2017 Authors: Hollenbaugh JA; Shelton J; Tao S; Amiralaei S; Liu P; Lu X; Goetze RW; Zhou L; Nettles JH; Schinazi RF
HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes.
Virology Volume: 499 Page(s): 383 - 396
12/01/2016 Authors: Anacker DC; Aloor HL; Shepard CN; Lenzi GM; Johnson BA; Kim B; Moody CA
Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.
Virol Rep Volume: 6 Page(s): 53 - 60
12/01/2016 Authors: White TE; Brandariz-Nuez A; Han K; Sawyer SL; Kim B; Diaz-Griffero F
SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.
Nat Med Volume: 22 Page(s): 1072 - 1074
10/06/2016 Authors: Antonucci JM; St Gelais C; de Silva S; Yount JS; Tang C; Ji X; Shepard C; Xiong Y; Kim B; Wu L
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells
Volume: 13
09/26/2016 Authors: Baldauf H-M; Stegmann L; Schwarz S-M; Trotard M; Martin M; Lenzi G; Burggraf M; Pan X; Fregoso OI; Lim ES
The small molecule 3G11 inhibits HIV-1 reverse transcription
Volume: 13
09/26/2016 Authors: Fricke T; Opp S; Shepard C; Ivanov D; Kim B; Valle-Casuso J; Diaz-Griffero F
Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.
J Virol Volume: 90 Page(s): 8059 - 8073
09/15/2016 Authors: Zerbato JM; Serrao E; Lenzi G; Kim B; Ambrose Z; Watkins SC; Engelman AN; Sluis-Cremer N
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.
Sci Rep Volume: 6 Page(s): 31353
08/11/2016 Authors: Bhattacharya A; Wang Z; White T; Buffone C; Nguyen LA; Shepard CN; Kim B; Demeler B; Diaz-Griffero F; Ivanov DN
SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.
Virology Volume: 495 Page(s): 92 - 100
08/01/2016 Authors: Bonifati S; Daly MB; St Gelais C; Kim SH; Hollenbaugh JA; Shepard C; Kennedy EM; Kim D-H; Schinazi RF; Kim B
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Proc Natl Acad Sci U S A Volume: 113 Page(s): E4338 - E4347
07/26/2016 Authors: Juvekar A; Hu H; Yadegarynia S; Lyssiotis CA; Ullas S; Lien EC; Bellinger G; Son J; Hok RC; Seth P
Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase.
Bioorg Med Chem Volume: 24 Page(s): 2410 - 2422
06/01/2016 Authors: Rawson JMO; Roth ME; Xie J; Daly MB; Clouser CL; Landman SR; Reilly CS; Bonnac L; Kim B; Patterson SE
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sci Rep Volume: 6 Page(s): 26616
05/27/2016 Authors: Sommer AFR; Rivire L; Qu B; Schott K; Riess M; Ni Y; Shepard C; Schnellbcher E; Finkernagel M; Himmelsbach K
Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.
Virology Volume: 491 Page(s): 106 - 114
04/01/2016 Authors: Hollenbaugh JA; Montero C; Schinazi RF; Munger J; Kim B
5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2'-Deoxycytidine.
Antimicrob Agents Chemother Volume: 60 Page(s): 2318 - 2325
04/01/2016 Authors: Rawson JMO; Daly MB; Xie J; Clouser CL; Landman SR; Reilly CS; Bonnac L; Kim B; Patterson SE; Mansky LM
Dual anti-HIV mechanism of clofarabine.
Retrovirology Volume: 13 Page(s): 20
03/24/2016 Authors: Daly MB; Roth ME; Bonnac L; Maldonado JO; Xie J; Clouser CL; Patterson SE; Kim B; Mansky LM
HIV-1 Reverse Transcriptase-Based Assay to Determine Cellular dNTP Concentrations.
Methods Mol Biol Volume: 1354 Page(s): 61 - 70
01/01/2016 Authors: Hollenbaugh JA; Kim B
Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.
Virology Volume: 487 Page(s): 273 - 284
01/01/2016 Authors: Wang F; St Gelais C; de Silva S; Zhang H; Geng Y; Shepard C; Kim B; Yount JS; Wu L
Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses.
J Biol Chem Volume: 290 Page(s): 30078 - 30086
12/11/2015 Authors: Lenzi GM; Domaoal RA; Kim D-H; Schinazi RF; Kim B
Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells.
Virology Volume: 485 Page(s): 313 - 321
11/01/2015 Authors: Hollenbaugh JA; Schader SM; Schinazi RF; Kim B
Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.
Stem Cell Res Volume: 15 Page(s): 271 - 280
09/01/2015 Authors: Li D; Schlaepfer E; Audig A; Rochat M-A; Ivic S; Knowlton CN; Kim B; Keppler OT; Speck RF
Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template.
Antiviral Res Volume: 115 Page(s): 75 - 82
03/01/2015 Authors: Nguyen LA; Domaoal RA; Kennedy EM; Kim D-H; Schinazi RF; Kim B
SAMHD1 prevents autoimmunity by maintaining genome stability.
Ann Rheum Dis Volume: 74 Page(s): e17
03/01/2015 Authors: Kretschmer S; Wolf C; Knig N; Staroske W; Guck J; Husler M; Luksch H; Nguyen LA; Kim B; Alexopoulou D
An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.
Mol Pharmacol Volume: 87 Page(s): 323 - 337
02/01/2015 Authors: Stevaert A; Nurra S; Pala N; Carcelli M; Rogolino D; Shepard C; Domaoal RA; Kim B; Alfonso-Prieto M; Marras SAE
Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.
Retrovirology Volume: 11 Page(s): 111
12/19/2014 Authors: Lenzi GM; Domaoal RA; Kim D-H; Schinazi RF; Kim B
Nonlinear dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
PURINERGIC SIGNALLING Volume: 10 Page(s): 696 - 696
12/01/2014 Authors: Hollenbaugh JA; Tao S; Lenzi G; Ryu S; Kim D-H; Schinazi RF; Kim B
Novel inhibitors of human immunodeficiency virus type 2 infectivity.
J Gen Virol Volume: 95 Page(s): 2778 - 2783
12/01/2014 Authors: Beach LB; Rawson JM; Kim B; Patterson SE; Mansky LM
dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.
Retrovirology Volume: 11 Page(s): 63
08/27/2014 Authors: Hollenbaugh JA; Tao S; Lenzi GM; Ryu S; Kim D-H; Diaz-Griffero F; Schinazi RF; Kim B
Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway.
J Med Food Volume: 17 Page(s): 849 - 854
08/01/2014 Authors: Jeong J-J; Kim B; Kim D-H
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Nat Med Volume: 20 Page(s): 936 - 941
08/01/2014 Authors: Ryoo J; Choi J; Oh C; Kim S; Seo M; Kim S-Y; Seo D; Kim J; White TE; Brandariz-Nuez A
Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.
Virology Volume: 460-461 Page(s): 34 - 44
07/01/2014 Authors: White TE; Brandariz-Nuez A; Valle-Casuso JC; Knowlton C; Kim B; Sawyer SL; Diaz-Griffero F
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
J Biol Chem Volume: 289 Page(s): 16640
06/13/2014 Authors: Amie SM; Daly MB; Noble E; Schinazi RF; Bambara RA; Kim B
Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block.
Proc Natl Acad Sci U S A Volume: 111 Page(s): E1325 - E1326
04/08/2014 Authors: Allouch A; David A; Amie SM; Lahouassa H; Chartier L; Margottin-Goguet F; Barr-Sinoussi F; Kim B; Sez-Cirin A; Pancino G
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Retrovirology Volume: 11 Page(s): 12
02/01/2014 Authors: Reinhard C; Bottinelli D; Kim B; Luban J
Host SAMHD1 protein promotes HIV-1 recombination in macrophages.
J Biol Chem Volume: 289 Page(s): 2489 - 2496
01/31/2014 Authors: Nguyen LA; Kim D-H; Daly MB; Allan KC; Kim B
SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.
PLoS One Volume: 9 Page(s): e89558
01/01/2014 Authors: Zhang R; Bloch N; Nguyen LA; Kim B; Landau NR
Restricted 5'-end gap repair of HIV-1 integration due to limited cellular dNTP concentrations in human primary macrophages.
J Biol Chem Volume: 288 Page(s): 33253 - 33262
11/15/2013 Authors: Van Cor-Hosmer SK; Kim D-H; Daly MB; Daddacha W; Kim B
Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.
Retrovirology Volume: 10 Page(s): 131
11/12/2013 Authors: Brandariz-Nuez A; Valle-Casuso JC; White TE; Nguyen L; Bhattacharya A; Wang Z; Demeler B; Amie S; Knowlton C; Kim B
p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.
Proc Natl Acad Sci U S A Volume: 110 Page(s): E3997 - E4006
10/15/2013 Authors: Allouch A; David A; Amie SM; Lahouassa H; Chartier L; Margottin-Goguet F; Barr-Sinoussi F; Kim B; Sez-Cirin A; Pancino G
Vpx rescue of HIV-1 from the antiviral state is independent of the intracellular nucleotide concentration
RETROVIROLOGY Volume: 10 Page(s): S28 - S28
09/19/2013 Authors: Reinhard C; Botinelli D; Kim B; Luban J
RNR2 repression by p21 restricts reverse transcription of HIV-1 and related-lentiviruses in macrophages
RETROVIROLOGY Volume: 10 Page(s): S5 - S6
09/19/2013 Authors: Allouch A; David A; Amie S; Lahouassa H; Chartier L; Margottin-Goguet F; Barre-Sinoussi F; Kim B; Saez-Cirion A; Pancino G
Interferon-alpha blocks HIV-1 infection in non-dividing myeloid cells despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
RETROVIROLOGY Volume: 10 Page(s): S27 - S27
09/19/2013 Authors: Dragin L; Nguyen L; Lahouassa H; Sourisce A; Kim B; Ramirez C; Margottin-Goguet F
GTP is the primary activator of the anti-HIV restriction factor SAMHD1.
J Biol Chem Volume: 288 Page(s): 25001 - 25006
08/30/2013 Authors: Amie SM; Bambara RA; Kim B
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
Cell Rep Volume: 4 Page(s): 689 - 696
08/29/2013 Authors: Behrendt R; Schumann T; Gerbaulet A; Nguyen LA; Schubert N; Alexopoulou D; Berka U; Lienenklaus S; Peschke K; Gibbert K
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
J Biol Chem Volume: 288 Page(s): 20683 - 20691
07/12/2013 Authors: Amie SM; Daly MB; Noble E; Schinazi RF; Bambara RA; Kim B
Effect of ribonucleotides embedded in a DNA template on HIV-1 reverse transcription kinetics and fidelity.
J Biol Chem Volume: 288 Page(s): 12522 - 12532
05/03/2013 Authors: Daddacha W; Noble E; Nguyen LA; Kennedy EM; Kim B
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.
Cell Host Microbe Volume: 13 Page(s): 441 - 451
04/17/2013 Authors: White TE; Brandariz-Nuez A; Valle-Casuso JC; Amie S; Nguyen LA; Kim B; Tuzova M; Diaz-Griffero F
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Bioorg Med Chem Volume: 21 Page(s): 2018 - 2024
04/01/2013 Authors: Alam MM; Joh E-H; Park H; Kim B; Kim D-H; Lee YS
Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply.
Retrovirology Volume: 10 Page(s): 30
03/11/2013 Authors: Dragin L; Nguyen LA; Lahouassa H; Sourisce A; Kim B; Ramirez BC; Margottin-Goguet F
Restriction of diverse retroviruses by SAMHD1.
Retrovirology Volume: 10 Page(s): 26
03/05/2013 Authors: Gramberg T; Kahle T; Bloch N; Wittmann S; Mllers E; Daddacha W; Hofmann H; Kim B; Lindemann D; Landau NR
Evidence for IFN-induced, SAMHD1-independent inhibitors of early HIV-1 infection.
Retrovirology Volume: 10 Page(s): 23
02/25/2013 Authors: Goujon C; Schaller T; Galo RP; Amie SM; Kim B; Olivieri K; Neil SJD; Malim MH
Intracellular nucleotide levels and the control of retroviral infections.
Virology Volume: 436 Page(s): 247 - 254
02/20/2013 Authors: Amie SM; Noble E; Kim B
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
Virology Volume: 436 Page(s): 81 - 90
02/05/2013 Authors: White TE; Brandariz-Nuez A; Valle-Casuso JC; Amie S; Nguyen L; Kim B; Brojatsch J; Diaz-Griffero F
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
PLoS Pathog Volume: 9 Page(s): e1003481
01/01/2013 Authors: Hollenbaugh JA; Gee P; Baker J; Daly MB; Amie SM; Tate J; Kasai N; Kanemura Y; Kim D-H; Ward BM
The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase.
PLoS One Volume: 8 Page(s): e68347
01/01/2013 Authors: Jin Z; Smith LK; Rajwanshi VK; Kim B; Deval J
Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1.
Biol Pharm Bull Volume: 36 Page(s): 1088 - 1094
01/01/2013 Authors: Jeong J-J; Kim B; Kim D-H
SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.
Retrovirology Volume: 9 Page(s): 105
12/11/2012 Authors: St Gelais C; de Silva S; Amie SM; Coleman CM; Hoy H; Hollenbaugh JA; Kim B; Wu L
The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.
J Virol Volume: 86 Page(s): 12552 - 12560
12/01/2012 Authors: Hofmann H; Logue EC; Bloch N; Daddacha W; Polsky SB; Schultz ML; Kim B; Landau NR
A small-RNA enhancer of viral polymerase activity.
J Virol Volume: 86 Page(s): 13475 - 13485
12/01/2012 Authors: Perez JT; Zlatev I; Aggarwal S; Subramanian S; Sachidanandam R; Kim B; Manoharan M; tenOever BR
Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.
Virology Volume: 433 Page(s): 27 - 34
11/10/2012 Authors: Noble E; Cox A; Deval J; Kim B
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nat Med Volume: 18 Page(s): 1682 - 1687
11/01/2012 Authors: Baldauf H-M; Pan X; Erikson E; Schmidt S; Daddacha W; Burggraf M; Schenkova K; Ambiel I; Wabnitz G; Gramberg T
Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.
J Virol Volume: 86 Page(s): 10484 - 10493
10/01/2012 Authors: Capella C; Beltejar M-J; Brown C; Fong V; Daddacha W; Kim B; Dewhurst S
Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.
J Biol Chem Volume: 287 Page(s): 21570 - 21574
06/22/2012 Authors: Kim B; Nguyen LA; Daddacha W; Hollenbaugh JA
Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies.
Virology Volume: 426 Page(s): 51 - 59
04/25/2012 Authors: MacDonald LA; Aggarwal S; Bussey KA; Desmet EA; Kim B; Takimoto T
Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages.
J Biol Chem Volume: 287 Page(s): 14280 - 14288
04/20/2012 Authors: Kennedy EM; Amie SM; Bambara RA; Kim B
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Nat Immunol Volume: 13 Page(s): 223 - 228
02/12/2012 Authors: Lahouassa H; Daddacha W; Hofmann H; Ayinde D; Logue EC; Dragin L; Bloch N; Maudet C; Bertrand M; Gramberg T
The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication.
Virology Volume: 422 Page(s): 393 - 401
01/20/2012 Authors: Van Cor-Hosmer SK; Daddacha W; Kelly Z; Tsurumi A; Kennedy EM; Kim B
Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion.
J Mol Biol Volume: 415 Page(s): 248 - 262
01/13/2012 Authors: Nguyen LA; Daddacha W; Rigby S; Bambara RA; Kim B
The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents.
Mol Biol Int Volume: 2012 Page(s): 625983
01/01/2012 Authors: Gavegnano C; Kennedy EM; Kim B; Schinazi RF
Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection.
PLoS Pathog Volume: 8 Page(s): e1002635
01/01/2012 Authors: Mock DJ; Hollenbaugh JA; Daddacha W; Overstreet MG; Lazarski CA; Fowell DJ; Kim B
Pleckstrin homology domain of Akt kinase: a proof of principle for highly specific and effective non-enzymatic anti-cancer target.
PLoS One Volume: 7 Page(s): e50424
01/01/2012 Authors: Joh E-H; Hollenbaugh JA; Kim B; Kim D-H
Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPS to toll-like receptor-4 on macrophages.
Int Immunopharmacol Volume: 12 Page(s): 110 - 116
01/01/2012 Authors: Kim T-W; Joh E-H; Kim B; Kim D-H
Synthesis and biological evaluation of cyclopentane-linked alkyl phosphocholines as potential anticancer agents that act by inhibiting Akt phosphorylation.
Eur J Med Chem Volume: 47 Page(s): 485 - 492
01/01/2012 Authors: Alam MM; Joh E-H; Kim Y; Oh YI; Hong J; Kim B; Kim D-H; Lee YS
Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.
J Biol Chem Volume: 286 Page(s): 34504 - 34513
10/07/2011 Authors: Aggarwal S; Dewhurst S; Takimoto T; Kim B
HIV-1 reverse transcriptase dissociates during strand transfer.
J Mol Biol Volume: 412 Page(s): 354 - 364
09/23/2011 Authors: Muchiri JM; Rigby ST; Nguyen LA; Kim B; Bambara RA
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.
J Biol Chem Volume: 286 Page(s): 25047 - 25055
07/15/2011 Authors: Kennedy EM; Daddacha W; Slater R; Gavegnano C; Fromentin E; Schinazi RF; Kim B
Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC-MS/MS analysis.
Virology Volume: 415 Page(s): 153 - 159
07/05/2011 Authors: Hollenbaugh JA; Munger J; Kim B
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.
J Virol Volume: 85 Page(s): 7020 - 7028
07/01/2011 Authors: Bussey KA; Desmet EA; Mattiacio JL; Hamilton A; Bradel-Tretheway B; Bussey HE; Kim B; Dewhurst S; Takimoto T
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.
J Biol Chem Volume: 286 Page(s): 22965 - 22970
07/01/2011 Authors: Noble E; Mathews DH; Chen JL; Turner DH; Takimoto T; Kim B
Frequent incorporation of non-canonical dUTP by human immunodeficiency virus type 1 reverse transcriptase in primary human macrophage
Volume: 16 Page(s): A125 - A125
01/01/2011 Authors: Kennedy EM; Daddacha W; Slater R; Gavegnano C; Fromentin E; Schinazi RE; Kim B
Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.
PLoS One Volume: 6 Page(s): e21781
01/01/2011 Authors: Kim Y; Hollenbaugh JA; Kim D-H; Kim B
Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages.
J Biol Chem Volume: 285 Page(s): 39380 - 39391
12/10/2010 Authors: Kennedy EM; Gavegnano C; Nguyen L; Slater R; Lucas A; Fromentin E; Schinazi RF; Kim B
Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity.
Virology Volume: 406 Page(s): 253 - 260
10/25/2010 Authors: Van Cor-Hosmer SK; Daddacha W; Kim B
Targeting the PI3K/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds.
PLoS One Volume: 5
09/30/2010 Authors: Lucas A; Kim Y; Rivera-Pabon O; Chae S; Kim D-H; Kim B
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.
J Virol Volume: 84 Page(s): 4395 - 4406
05/01/2010 Authors: Bussey KA; Bousse TL; Desmet EA; Kim B; Takimoto T
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
PLoS One Volume: 5 Page(s): e10372
04/29/2010 Authors: Aggarwal S; Bradel-Tretheway B; Takimoto T; Dewhurst S; Kim B
The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate.
Biochemistry Volume: 48 Page(s): 11161 - 11168
12/01/2009 Authors: Kennedy EM; Hergott C; Dewhurst S; Kim B
Mechanistic variations among reverse transcriptases of simian immunodeficiency virus variants isolated from African green monkeys.
Biochemistry Volume: 48 Page(s): 5389 - 5395
06/16/2009 Authors: Skasko M; Diamond TL; Kim B
Nef gene evolution from a single transmitted strain in acute SIV infection.
Retrovirology Volume: 6 Page(s): 57
06/08/2009 Authors: Bimber BN; Chugh P; Giorgi EE; Kim B; Almudevar AL; Dewhurst S; O'Connor DH; Lee HY
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.
J Gen Virol Volume: 89 Page(s): 2923 - 2932
12/01/2008 Authors: Bradel-Tretheway BG; Kelley Z; Chakraborty-Sett S; Takimoto T; Kim B; Dewhurst S
Compensatory role of human immunodeficiency virus central polypurine tract sequence in kinetically disrupted reverse transcription.
J Virol Volume: 82 Page(s): 7716 - 7720
08/01/2008 Authors: Skasko M; Kim B
Deoxynucleoside triphosphate incorporation mechanism of foamy virus (FV) reverse transcriptase: implications for cell tropism of FV.
J Virol Volume: 82 Page(s): 8235 - 8238
08/01/2008 Authors: Santos-Velazquez J; Kim B
Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage.
J Biol Chem Volume: 283 Page(s): 9206 - 9216
04/04/2008 Authors: Jamburuthugoda VK; Santos-Velazquez JM; Skasko M; Operario DJ; Purohit V; Chugh P; Szymanski EA; Wedekind JE; Bambara RA; Kim B
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
J Biol Chem Volume: 283 Page(s): 9196 - 9205
04/04/2008 Authors: Gao L; Hanson MN; Balakrishnan M; Boyer PL; Roques BP; Hughes SH; Kim B; Bambara RA
Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis.
J Mol Biol Volume: 375 Page(s): 1234 - 1248
02/01/2008 Authors: Matamoros T; Kim B; Menndez-Arias L
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.
Retrovirology Volume: 5 Page(s): 11
01/31/2008 Authors: Chugh P; Bradel-Tretheway B; Monteiro-Filho CMR; Planelles V; Maggirwar SB; Dewhurst S; Kim B
Mechanisms that prevent template inactivation by HIV-1 reverse transcriptase RNase H cleavages.
J Biol Chem Volume: 282 Page(s): 12598 - 12609
04/27/2007 Authors: Purohit V; Roques BP; Kim B; Bambara RA
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.
J Mol Biol Volume: 366 Page(s): 67 - 81
02/09/2007 Authors: Chugh P; Fan S; Planelles V; Maggirwar SB; Dewhurst S; Kim B
Death induction of human immunodeficiency virus-infected macrophages using anti-PI3K/Akt pathway agents
Volume: 13 Page(s): 72 - 72
01/01/2007 Authors: Chugh P; Planelles V; Maggirwar S; Dewhurst S; Kim B
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
PLoS Pathog Volume: 2 Page(s): e127
12/01/2006 Authors: Andersen JL; DeHart JL; Zimmerman ES; Ardon O; Kim B; Jacquot G; Benichou S; Planelles V
Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer.
J Biol Chem Volume: 281 Page(s): 32113 - 32121
10/27/2006 Authors: Operario DJ; Balakrishnan M; Bambara RA; Kim B
Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations.
J Biol Chem Volume: 281 Page(s): 13388 - 13395
05/12/2006 Authors: Jamburuthugoda VK; Chugh P; Kim B
Characterization of specific HHV-6 and cell cycle genes implicated in virus-mediated G1/S cell-cycle arrest of glial precursors
RETROVIROLOGY Volume: 3
01/01/2006 Authors: Mock DJ; Chugh P; Kim B; Proschel C; Dietrich J; Strathmann F; Blumberg BM; Mayer-Proschel M
Evidence that HIV-1 reverse transcriptase employs the DNA 3' end-directed primary/secondary RNase H cleavage mechanism during synthesis and strand transfer.
J Biol Chem Volume: 280 Page(s): 40534 - 40543
12/09/2005 Authors: Purohit V; Balakrishnan M; Kim B; Bambara RA
Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate.
Biochemistry Volume: 44 Page(s): 10635 - 10643
08/09/2005 Authors: Jamburuthugoda VK; Guo D; Wedekind JE; Kim B
Comparison of DNA polymerase activities between recombinant feline immunodeficiency and leukemia virus reverse transcriptases.
Virology Volume: 335 Page(s): 106 - 121
04/25/2005 Authors: Operario DJ; Reynolds HM; Kim B
Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases.
J Biol Chem Volume: 280 Page(s): 12190 - 12200
04/01/2005 Authors: Skasko M; Weiss KK; Reynolds HM; Jamburuthugoda V; Lee K; Kim B
The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration.
J Virol Volume: 79 Page(s): 1389 - 1396
02/01/2005 Authors: Dehart JL; Andersen JL; Zimmerman ES; Ardon O; An DS; Blackett J; Kim B; Planelles V
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase.
J Biol Chem Volume: 279 Page(s): 51545 - 51553
12/03/2004 Authors: Diamond TL; Roshal M; Jamburuthugoda VK; Reynolds HM; Merriam AR; Lee KY; Balakrishnan M; Bambara RA; Planelles V; Dewhurst S
A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis.
Biochemistry Volume: 43 Page(s): 4490 - 4500
04/20/2004 Authors: Weiss KK; Chen R; Skasko M; Reynolds HM; Lee K; Bambara RA; Mansky LM; Kim B
Infection of human glial precursor cells induces GVS cell-cycle arrest and alteration of critical cell functions related to activation of DNA damage mechanisms
JOURNAL OF NEUROVIROLOGY Volume: 10 Page(s): 31 - 31
01/01/2004 Authors: Chugh P; Kim B; Proschel C; Arhin A; Dietrich J; Blumberg BM; Baker JV; Roshal M; Hurley SD; Mayer-Proschel M
Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque.
J Biol Chem Volume: 278 Page(s): 29913 - 29924
08/08/2003 Authors: Diamond TL; Souroullas G; Weiss KK; Lee KY; Bambara RA; Dewhurst S; Kim B
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.
J Biol Chem Volume: 278 Page(s): 25879 - 25886
07/11/2003 Authors: Roshal M; Kim B; Zhu Y; Nghiem P; Planelles V
Mechanistic role of residue Gln151 in error prone DNA synthesis by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Pre-steady state kinetic study of the Q151N HIV-1 RT mutant with increased fidelity.
J Biol Chem Volume: 277 Page(s): 22662 - 22669
06/21/2002 Authors: Weiss KK; Bambara RA; Kim B
In vitro assay for site-specific proteases using bead-attached GFP substrate.
Biotechniques Volume: 31 Page(s): 1194 - passim
11/01/2001 Authors: Patel D; Frelinger J; Goudsmit J; Kim B
Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell Volume: 106 Page(s): 585 - 594
09/07/2001 Authors: Luo Y; Pfuetzner RA; Mosimann S; Paetzel M; Frey EA; Cherney M; Kim B; Little JW; Strynadka NC
Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection.
J Biol Chem Volume: 276 Page(s): 23624 - 23631
06/29/2001 Authors: Diamond TL; Kimata J; Kim B
Thermal effects on reverse transcription: improvement of accuracy and processivity in cDNA synthesis.
Biotechniques Volume: 30 Page(s): 1074 - passim
05/01/2001 Authors: Malboeuf CM; Isaacs SJ; Tran NH; Kim B
Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions.
Biochemistry Volume: 39 Page(s): 10684 - 10694
09/05/2000 Authors: Weiss KK; Isaacs SJ; Tran NH; Adman ET; Kim B
New human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) mutants with increased fidelity of DNA synthesis. Accuracy, template binding, and processivity.
J Biol Chem Volume: 274 Page(s): 27666 - 27673
09/24/1999 Authors: Kim B; Ayran JC; Sagar SG; Adman ET; Fuller SM; Tran NH; Horrigan J
Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis.
Biochemistry Volume: 37 Page(s): 5831 - 5839
04/28/1998 Authors: Kim B; Hathaway TR; Loeb LA
HIV reverse transcriptase and viral evolution.
JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 142A - 142A
01/01/1998 Authors: Hathaway TR; Kim B; Loeb LA
Genetic selection in Escherichia coli for active human immunodeficiency virus reverse transcriptase mutants.
Methods Volume: 12 Page(s): 318 - 324
08/01/1997 Authors: Kim B
Tolerance of different proteins for amino acid diversity.
Mol Divers Volume: 2 Page(s): 111 - 118
10/01/1996 Authors: Suzuki M; Christians FC; Kim B; Skandalis A; Black ME; Loeb LA
Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli.
J Biol Chem Volume: 271 Page(s): 4872 - 4878
03/01/1996 Authors: Kim B; Hathaway TR; Loeb LA
A screen in Escherichia coli for nucleoside analogs that target human immunodeficiency virus (HIV) reverse transcriptase: coexpression of HIV reverse transcriptase and herpes simplex virus thymidine kinase.
J Virol Volume: 69 Page(s): 6563 - 6566
10/01/1995 Authors: Kim B; Loeb LA
DNA POLYMERASE-DELTA IS REQUIRED FOR BASE EXCISION-REPAIR OF DNA METHYLATION DAMAGE IN SACCHAROMYCES-CEREVISIAE
JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 305 - 305
03/10/1995 Authors: BLANK A; KIM B; LOEB LA
Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli.
Proc Natl Acad Sci U S A Volume: 92 Page(s): 684 - 688
01/31/1995 Authors: Kim B; Loeb LA
DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A Volume: 91 Page(s): 9047 - 9051
09/13/1994 Authors: Blank A; Kim B; Loeb LA
Cleavage of LexA repressor.
Methods Enzymol Volume: 244 Page(s): 266 - 284
01/01/1994 Authors: Little JW; Kim B; Roland KL; Smith MH; Lin LL; Slilaty SN
LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.
Cell Volume: 73 Page(s): 1165 - 1173
06/18/1993 Authors: Kim B; Little JW
Dimerization of a specific DNA-binding protein on the DNA.
Science Volume: 255 Page(s): 203 - 206
01/10/1992 Authors: Kim B; Little JW

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Baek Kim

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