Publications

• An early precursor CD8+ T cell that adapts to acute or chronic viral infection.
  Nature Volume: 640 Page(s): 772 - 781
  04/01/2025 Authors: McManus DT; Valanparambil RM; Medina CB; Scharer CD; McGuire DJ; Sobierajska E; Hu Y; Chang DY; Wieland A; Lee J
• Identification of indirect CD4+ Tcell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction.
  Immunity Volume: 58 Page(s): 448 - 464.e6
  02/11/2025 Authors: Zhanzak Z; Johnson AC; Foster P; Cardenas MA; Morris AB; Zhang J; Karadkhele G; Badell IR; Morris AA; Au-Yeung BB
• Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice.
  Nat Commun Volume: 16 Page(s): 784
  01/17/2025 Authors: Nielsen HV; Yang L; Mueller JL; Ritter AJ; Hiwa R; Proekt I; Rackaityte E; Aylard D; Gupta M; Scharer CD
• Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis.
  Sci Immunol Volume: 10 Page(s): eadl4909
  01/10/2025 Authors: Elkins C; Ye C; Sivasami P; Mulpur R; Diaz-Saldana PP; Peng A; Xu M; Chiang Y-P; Moll S; Rivera-Rodriguez DE
• Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics.
  Sci Immunol Volume: 9 Page(s): eadj7238
  03/15/2024 Authors: Turner L; Van Le TN; Cross E; Queriault C; Knight M; Trihemasava K; Davis J; Schaefer P; Nguyen J; Xu J
• Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection.
  
  02/12/2024 Authors: McManus DT; Valanparambil RM; Medina CB; Hu Y; Scharer CD; Sobierajska E; Chang DY; Wieland A; Lee J; Nasti TH
• Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling.
  Sci Signal Volume: 17 Page(s): eadh0439
  02/06/2024 Authors: Eggert J; Zinzow-Kramer WM; Hu Y; Kolawole EM; Tsai Y-L; Weiss A; Evavold BD; Salaita K; Scharer CD; Au-Yeung BB
• The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces.
  
  02/02/2024 Authors: Kellner AV; Hunter R; Do P; Eggert J; Jaffe M; Geitgey DK; Lee M; Hamilton JAG; Ross AJ; Ank RS
• Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness.
  
  01/28/2023 Authors: Eggert J; Zinzow-Kramer WM; Hu Y; Tsai Y-L; Weiss A; Salaita K; Scharer CD; Au-Yeung BB
• The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival.
  Nat Immunol Volume: 24 Page(s): 136 - 147
  01/01/2023 Authors: Lu W; Helou YA; Shrinivas K; Liou J; Au-Yeung BB; Weiss A
• Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4+ T Cells.
  Immunohorizons Volume: 6 Page(s): 671 - 683
  09/13/2022 Authors: Zinzow-Kramer WM; Kolawole EM; Eggert J; Evavold BD; Scharer CD; Au-Yeung BB
• Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals.
  Curr Opin Immunol Volume: 73 Page(s): 43 - 49
  12/01/2021 Authors: Eggert J; Au-Yeung BB
• The phosphatidinositol-transfer protein Nir3 is a modulator of T cell development
  Volume: 204
  05/01/2020 Authors: Helou Y; Au-Yeung BB; Weiss A
• CD4+T cells are more sensitive to inhibition of TCR signaling under Th17 polarizing conditions
  Volume: 204
  05/01/2020 Authors: Zinzow-Kramer WM; Weiss A; Au-Yeung BB
• Basal TCR signaling drives the functional heterogeneity of naive CD4+T cells
  Volume: 204
  05/01/2020 Authors: Au-Yeung BB; Weiss A; Zinzow-Kramer W
• Adaptation by nave CD4+ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance.
  Proc Natl Acad Sci U S A Volume: 116 Page(s): 15160 - 15169
  07/23/2019 Authors: Zinzow-Kramer WM; Weiss A; Au-Yeung BB
• ZAP-70 in Signaling, Biology, and Disease.
  Annu Rev Immunol Volume: 36 Page(s): 127 - 156
  04/26/2018 Authors: Au-Yeung BB; Shah NH; Shen L; Weiss A
• A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
  Mol Cell Volume: 67 Page(s): 498 - 511.e6
  08/03/2017 Authors: Courtney AH; Amacher JF; Kadlecek TA; Mollenauer MN; Au-Yeung BB; Kuriyan J; Weiss A
• IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.
  J Immunol Volume: 198 Page(s): 2445 - 2456
  03/15/2017 Authors: Au-Yeung BB; Smith GA; Mueller JL; Heyn CS; Jaszczak RG; Weiss A; Zikherman J
• CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.
  PLoS One Volume: 11 Page(s): e0152996
  01/01/2016 Authors: Cme C; Cvrljevic A; Khan MM; Treise I; Adler T; Aguilar-Pimentel JA; Au-Yeung B; Sittig E; Laajala TD; Chen Y
• The role of T cell receptor signaling thresholds in guiding T cell fate decisions.
  Curr Opin Immunol Volume: 33 Page(s): 43 - 48
  04/01/2015 Authors: Zikherman J; Au-Yeung B
• A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): E3679 - E3688
  09/02/2014 Authors: Au-Yeung BB; Zikherman J; Mueller JL; Ashouri JF; Matloubian M; Cheng DA; Chen Y; Shokat KM; Weiss A
• DECLINED PRESENTATION A T CELL RECEPTOR SIGNAL THRESHOLD DETERMINES POSITIVE SELECTION
  Volume: 42 Page(s): S49 - S49
  08/01/2014 Authors: Melichar H; Au-Yeung B; Ross J; Weiss A; Robey E
• Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
  Nat Immunol Volume: 15 Page(s): 687 - 694
  07/01/2014 Authors: Au-Yeung BB; Melichar HJ; Ross JO; Cheng DA; Zikherman J; Shokat KM; Robey EA; Weiss A
• Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): E2550 - E2558
  06/24/2014 Authors: Ross JO; Melichar HJ; Au-Yeung BB; Herzmark P; Weiss A; Robey EA
• Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.
  Elife Volume: 3 Page(s): e02270
  05/13/2014 Authors: Phee H; Au-Yeung BB; Pryshchep O; O'Hagan KL; Fairbairn SG; Radu M; Kosoff R; Mollenauer M; Cheng D; Chernoff J
• Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
  Elife Volume: 3 Page(s): e01310
  03/04/2014 Authors: Jenkins MR; Stinchcombe JC; Au-Yeung BB; Asano Y; Ritter AT; Weiss A; Griffiths GM
• Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4 T cells.
  Immunity Volume: 39 Page(s): 560 - 572
  09/19/2013 Authors: Gardner JM; Metzger TC; McMahon EJ; Au-Yeung BB; Krawisz AK; Lu W; Price JD; Johannes KP; Satpathy AT; Murphy KM
• Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
  Sci Signal Volume: 6 Page(s): ra1
  01/01/2013 Authors: Mukherjee S; Zhu J; Zikherman J; Parameswaran R; Kadlecek TA; Wang Q; Au-Yeung B; Ploegh H; Kuriyan J; Das J
• Itk controls the spatiotemporal organization of T cell activation.
  Sci Signal Volume: 4 Page(s): ra66
  10/04/2011 Authors: Singleton KL; Gosh M; Dandekar RD; Au-Yeung BB; Ksionda O; Tybulewicz VLJ; Altman A; Fowell DJ; Wlfing C
• A genetically selective inhibitor reveals ZAP-70 kinase-dependent checkpoints in T cell development
  Volume: 186
  04/01/2011 Authors: Au-Yeung B; Cheng D; Zhang C; Shokat K; Weiss A
• A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
  Nat Immunol Volume: 11 Page(s): 1085 - 1092
  12/01/2010 Authors: Au-Yeung BB; Levin SE; Zhang C; Hsu L-Y; Cheng DA; Killeen N; Shokat KM; Weiss A
• ZAP-70: an essential kinase in T-cell signaling.
  Cold Spring Harb Perspect Biol Volume: 2 Page(s): a002279
  05/01/2010 Authors: Wang H; Kadlecek TA; Au-Yeung BB; Goodfellow HES; Hsu L-Y; Freedman TS; Weiss A
• Identifying ZAP-70 kinase-dependent and -independent functions in T cells using a chemical genetic approach
  Volume: 182
  04/01/2009 Authors: Au-Yeung BB; Levin SE; Zhang C; Shokat K; Weiss A
• The structure, regulation, and function of ZAP-70.
  Immunol Rev Volume: 228 Page(s): 41 - 57
  03/01/2009 Authors: Au-Yeung BB; Deindl S; Hsu L-Y; Palacios EH; Levin SE; Kuriyan J; Weiss A
• A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
  J Immunol Volume: 179 Page(s): 111 - 119
  07/01/2007 Authors: Au-Yeung BB; Fowell DJ
• Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function.
  J Immunol Volume: 176 Page(s): 3895 - 3899
  04/01/2006 Authors: Au-Yeung BB; Katzman SD; Fowell DJ