Amit Upadhyay
Research
Publications
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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.
Nat Commun Volume: 14 Page(s): 4789
08/08/2023 Authors: Bollimpelli VS; Reddy PBJ; Gangadhara S; Charles TP; Burton SL; Tharp GK; Styles TM; Labranche CC; Smith JC; Upadhyay AA -
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques.
Nat Commun Volume: 14 Page(s): 1914
04/06/2023 Authors: Upadhyay AA; Viox EG; Hoang TN; Boddapati AK; Pino M; Lee MY-H; Corry J; Strongin Z; Cowan DA; Beagle EN -
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
bioRxiv
10/24/2022 Authors: Hoang TN; Viox EG; Upadhyay AA; Strongin Z; Tharp GK; Pino M; Nchioua R; Hirschenberger M; Gagne M; Nguyen K -
A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
PLoS Pathog Volume: 18 Page(s): e1010488
05/01/2022 Authors: Welbourn S; Chakraborty S; Yang JE; Gleinich AS; Gangadhara S; Khan S; Ferrebee C; Yagnik B; Burton S; Charles T -
Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates.
PLoS Pathog Volume: 18 Page(s): e1010395
03/01/2022 Authors: Corry J; Kettenburg G; Upadhyay AA; Wallace M; Marti MM; Wonderlich ER; Bissel SJ; Goss K; Sturgeon TJ; Watkins SC -
From structure to sequence: Antibody discovery using cryoEM.
Sci Adv Volume: 8 Page(s): eabk2039
01/21/2022 Authors: Antanasijevic A; Bowman CA; Kirchdoerfer RN; Cottrell CA; Ozorowski G; Upadhyay AA; Cirelli KM; Carnathan DG; Enemuo CA; Sewall LM -
Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.
PLoS Pathog Volume: 17 Page(s): e1009674
06/01/2021 Authors: Lee MY-H; Upadhyay AA; Walum H; Chan CN; Dawoud RA; Grech C; Harper JL; Karunakaran KA; Nelson SA; Mahar EA -
IL-21 and IFN therapy rescues terminallydifferentiated NK cells and limits SIV reservoir in ART-treated macaques.
Nat Commun Volume: 12 Page(s): 2866
05/17/2021 Authors: Harper J; Huot N; Micci L; Tharp G; King C; Rascle P; Shenvi N; Wang H; Galardi C; Upadhyay AA -
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Immunity Volume: 54 Page(s): 542 - 556.e9
03/09/2021 Authors: Routhu NK; Cheedarla N; Gangadhara S; Bollimpelli VS; Boddapati AK; Shiferaw A; Rahman SA; Sahoo A; Edara VV; Lai L -
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell Volume: 184 Page(s): 460 - 475.e21
01/21/2021 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Nekorchuk M; Busman-Sahay K; Strongin Z