Publications

• Time-dependent neuropathology in rats following organophosphate-induced status epilepticus.
  Neurotoxicology Volume: 91 Page(s): 45 - 59
  07/01/2022 Authors: Rojas A; Abreu-Melon J; Wang S; Dingledine R
• Pharmacological antagonism of EP2 receptor does not modify basal cardiovascular and respiratory function, blood cell counts, and bone morphology in animal models.
  Biomed Pharmacother Volume: 147 Page(s): 112646
  03/01/2022 Authors: Rawat V; Banik A; Amaradhi R; Rojas A; Taval S; Nagy T; Dingledine R; Ganesh T
• Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link.
  Int J Mol Sci Volume: 22
  11/20/2021 Authors: Bonilla-Jaime H; Zeleke H; Rojas A; Espinosa-Garcia C
• Impact of Stress on Epilepsy: Focus on Neuroinflammation-A Mini Review.
  Int J Mol Sci Volume: 22
  04/14/2021 Authors: Espinosa-Garcia C; Zeleke H; Rojas A
• A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats.
  Neurotherapeutics Volume: 18 Page(s): 1207 - 1225
  04/01/2021 Authors: Rojas A; Amaradhi R; Banik A; Jiang C; Abreu-Melon J; Wang S; Dingledine R; Ganesh T
• Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman.
  Neurotoxicology Volume: 83 Page(s): 14 - 27
  03/01/2021 Authors: Rojas A; McCarren HS; Wang J; Wang W; Abreu-Melon J; Wang S; McDonough JH; Dingledine R
• Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
  Neurobiol Dis Volume: 140 Page(s): 104863
  07/01/2020 Authors: Rojas A; Wang J; Glover A; Dingledine R
• Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.
  J Med Chem Volume: 63 Page(s): 1032 - 1050
  02/13/2020 Authors: Amaradhi R; Banik A; Mohammed S; Patro V; Rojas A; Wang W; Motati DR; Dingledine R; Ganesh T
• A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.
  Neurobiol Dis Volume: 133 Page(s): 104399
  01/01/2020 Authors: Rojas A; Ganesh T; Wang W; Wang J; Dingledine R
• Novel Microglia Cell Line Expressing the Human EP2 Receptor.
  ACS Chem Neurosci Volume: 10 Page(s): 4280 - 4292
  10/16/2019 Authors: Rojas A; Banik A; Chen D; Flood K; Ganesh T; Dingledine R
• Development of water soluble, brain permeable EP2 receptor antagonist: Lead-optimization and in vitro proof-of-concept studies
  Volume: 257
  03/31/2019 Authors: Amaradhi R; Banik A; Mohammed S; Patro V; Rojas A; Wang W; Dingledine R; Ganesh T
• 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.
  J Alzheimers Dis Volume: 70 Page(s): 1259 - 1274
  01/01/2019 Authors: Manji Z; Rojas A; Wang W; Dingledine R; Varvel NH; Ganesh T
• The COX-2/prostanoid signaling cascades in seizure disorders.
  Expert Opin Ther Targets Volume: 23 Page(s): 1 - 13
  01/01/2019 Authors: Rojas A; Chen D; Ganesh T; Varvel NH; Dingledine R
• Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model.
  eNeuro Volume: 5
  01/01/2018 Authors: Rojas A; Wang W; Glover A; Manji Z; Fu Y; Dingledine R
• Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist.
  ACS Chem Neurosci Volume: 8 Page(s): 712 - 717
  04/19/2017 Authors: Rojas A; Ganesh T; Walker A; Dingledine R
• Inhibition of pilocarpine-induced fluid secretion by ethylatropine bromide
  Volume: 253
  04/02/2017 Authors: Ganesh T; Rojas A; Walker A; Dingledine R
• Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats.
  Neuropharmacology Volume: 110 Page(s): 419 - 430
  11/01/2016 Authors: Rojas A; Ganesh T; Manji Z; O'neill T; Dingledine R
• Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus.
  Neuropharmacology Volume: 93 Page(s): 15 - 27
  06/01/2015 Authors: Rojas A; Ganesh T; Lelutiu N; Gueorguieva P; Dingledine R
• The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
  Neurobiol Dis Volume: 70 Page(s): 74 - 89
  10/01/2014 Authors: Rojas A; Gueorguieva P; Lelutiu N; Quan Y; Shaw R; Dingledine R
• Cyclooxygenase-2 in epilepsy.
  Epilepsia Volume: 55 Page(s): 17 - 25
  01/01/2014 Authors: Rojas A; Jiang J; Ganesh T; Yang M-S; Lelutiu N; Gueorguieva P; Dingledine R
• Ionotropic glutamate receptors: regulation by G-protein-coupled receptors.
  Mol Pharmacol Volume: 83 Page(s): 746 - 752
  04/01/2013 Authors: Rojas A; Dingledine R
• Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
  Mol Pharmacol Volume: 83 Page(s): 106 - 121
  01/01/2013 Authors: Rojas A; Wetherington J; Shaw R; Serrano G; Swanger S; Dingledine R
• Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 3149 - 3154
  02/21/2012 Authors: Jiang J; Ganesh T; Du Y; Quan Y; Serrano G; Qui M; Speigel I; Rojas A; Lelutiu N; Dingledine R
• Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.
  J Neurosci Volume: 31 Page(s): 14850 - 14860
  10/19/2011 Authors: Serrano GE; Lelutiu N; Rojas A; Cochi S; Shaw R; Makinson CD; Wang D; FitzGerald GA; Dingledine R
• Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons.
  Biochem Biophys Res Commun Volume: 394 Page(s): 285 - 290
  04/02/2010 Authors: Zhang X; Su J; Rojas A; Jiang C
• Subunit-specific desensitization of heteromeric kainate receptors.
  J Physiol Volume: 588 Page(s): 683 - 700
  02/15/2010 Authors: Mott DD; Rojas A; Fisher JL; Dingledine RJ; Benveniste M
• Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.
  Proc Natl Acad Sci U S A Volume: 107 Page(s): 2307 - 2312
  02/02/2010 Authors: Jiang J; Ganesh T; Du Y; Thepchatri P; Rojas A; Lewis I; Kurtkaya S; Li L; Qui M; Serrano G
• Modulation of the heteromeric Kir4.1-Kir5.1 channel by multiple neurotransmitters via Galphaq-coupled receptors.
  J Cell Physiol Volume: 214 Page(s): 84 - 95
  01/01/2008 Authors: Rojas A; Su J; Yang L; Lee M; Cui N; Zhang X; Fountain D; Jiang C
• Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.
  Biochim Biophys Acta Volume: 1768 Page(s): 2030 - 2042
  09/01/2007 Authors: Rojas A; Cui N; Su J; Yang L; Muhumuza J-P; Jiang C
• PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors.
  Am J Physiol Regul Integr Comp Physiol Volume: 293 Page(s): R1205 - R1214
  09/01/2007 Authors: Shi Y; Wu Z; Cui N; Shi W; Yang Y; Zhang X; Rojas A; Ha BT; Jiang C
• High CO2 chemosensitivity versus wide sensing spectrum: a paradoxical problem and its solutions in cultured brainstem neurons.
  J Physiol Volume: 578 Page(s): 831 - 841
  02/01/2007 Authors: Su J; Yang L; Zhang X; Rojas A; Shi Y; Jiang C
• Gating of the ATP-sensitive K+ channel by a pore-lining phenylalanine residue.
  Biochim Biophys Acta Volume: 1768 Page(s): 39 - 51
  01/01/2007 Authors: Rojas A; Wu J; Wang R; Jiang C
• Inhibition of the heteromeric Kir4.1-Kir5.1 channel by G alpha q coupled receptor activation
  Volume: 19 Page(s): A647 - A647
  03/04/2005 Authors: Rojas A; Fountain D; Baro D; Jiang C
• Determinant role of membrane helices in K ATP channel gating.
  J Membr Biol Volume: 204 Page(s): 1 - 10
  03/01/2005 Authors: Wang R; Rojas A; Wu J; Piao H; Adams CY; Xu H; Shi Y; Wang Y; Jiang C
• CO2 central chemosensitivity: why are there so many sensing molecules?
  Respir Physiol Neurobiol Volume: 145 Page(s): 115 - 126
  02/15/2005 Authors: Jiang C; Rojas A; Wang R; Wang X
• Disruption of glucose sensing and insulin secretion by ribozyme Kir6.2-gene targeting in insulin-secreting cells.
  Endocrinology Volume: 145 Page(s): 4408 - 4414
  09/01/2004 Authors: Li L; Rojas A; Wu J; Jiang C
• Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
  Proc Natl Acad Sci U S A Volume: 101 Page(s): 1087 - 1092
  01/27/2004 Authors: Mao J; Wang X; Chen F; Wang R; Rojas A; Shi Y; Piao H; Jiang C
• Inhibition of G-protein coupled inward rectifier K+ channels by protein kinase C
  Volume: 86 Page(s): 440A - 440A
  01/01/2004 Authors: Mao JZ; Wang RP; Chen FX; Shi Y; Wang XR; Rojas A; Jiang C
• Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP.
  J Cell Physiol Volume: 198 Page(s): 73 - 81
  01/01/2004 Authors: Wu J; Piao H; Rojas A; Wang R; Wang Y; Cui N; Shi Y; Chen F; Jiang C
• A threonine residue (Thr71) at the intracellular end of the M1 helix plays a critical role in the gating of Kir6.2 channels by intracellular ATP and protons.
  J Membr Biol Volume: 192 Page(s): 111 - 122
  03/15/2003 Authors: Cui N; Wu J; Xu H; Wang R; Rojas A; Piao H; Mao J; Abdulkadir L; Li L; Jiang C
• Phe168 at the narrowest part of the ion-conductive pore is involved in Kir6.2 channel gating by intracellular protons.
  Volume: 84 Page(s): 81A - 82A
  02/01/2003 Authors: Rojas A; Wang R; Wallace T; Cui N; Jiang C
• Modulation of the heteromeric Kir4.1-Kir5.1 channels by P(CO(2)) at physiological levels.
  J Cell Physiol Volume: 189 Page(s): 229 - 236
  11/01/2001 Authors: Cui N; Giwa LR; Xu H; Rojas A; Abdulkadir L; Jiang C
• Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.
  J Biol Chem Volume: 276 Page(s): 36673 - 36680
  09/28/2001 Authors: Piao H; Cui N; Xu H; Mao J; Rojas A; Wang R; Abdulkadir L; Li L; Wu J; Jiang C