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Profile

Ashish Mehta MD, MSc

  • Department of Medicine
    Associate Professor
  • (404) 321-6111
  • amehta4@emory.edu
Head shot of Ashish Mehta

Overview

Dr. Mehta completed undergraduate and medical school education at the University of Missouri-Kansas City and received his MD in 2003. He then came to Emory University where he completed residency in Internal Medicine and fellowship in Pulmonary and Critical Care. During fellowship he worked in Dr. David Guidots laboratory investigating mechanisms of alcohol-induced lung injury. When he finished fellowship, he remained at Emory and joined the faculty as an Assistant Professor in 2009 with a two year career development award from the Atlanta VA Medical Center. He has since received another five year career development award and serves as the medical director of the intensive care unit at the Atlanta VA. He also completed a masters degree in clinical research, which he received from the Laney Graduate School at Emory in 2013.

Dr. Mehtas research involves clinical translational projects evaluating the role of alcohol abuse in predisposing individuals to pneumonia and acute lung injury. Specifically, he investigates the role of zinc deficiency and oxidative stress on alveolar macrophage immune function. He is currently running a large 5 year randomized clinical trial evaluating the role of dietary antioxidants and zinc on lung immune function in alcoholic subjects. His clinical time is at the Atlanta VA Medical Center, and he is interested in the use of ultrasonography in critical care. He is very involved in ultrasound education and serves on the division ultrasound committee that is responsible for the training of fellows and faculty.

Academic Appointment

  • Assistant Professor of Medicine, Emory University School of Medicine

Education

Degrees

  • MD from University of Missouri
  • BA from University of Missouri
  • MSCR from Emory University Laney Graduate School

Research

Focus

  • My primary research interest involves alcohol-induced lung disease, with a particular focus on how alcohol abuse impairs lung immune function and predisposes individuals to pneumonia and acute lung injury. More specifically, my research involves mechanisms by which alcohol abuse interferes with zinc bioavailability in the lung, how this deficiency impacts alveolar macrophage immune function, and the potential role of dietary zinc and antioxidant supplements in reversing certain features of the alcoholic lung phenotype.

Publications

  • A Data-driven Approach to Selecting Pulmonary and Critical Care Fellows for Interviews.
    ATS Sch Volume: 6 Page(s): 85 - 93
    03/01/2025 Authors: Kempker JA; Mehta AJ; Allam JS
  • Pioglitazone reverses alcohol-induced alterations in alveolar macrophage mitochondrial phenotype.
    Alcohol Clin Exp Res (Hoboken) Volume: 48 Page(s): 810 - 826
    05/01/2024 Authors: Crotty KM; Kabir SA; Chang SS; Mehta AJ; Yeligar SM
  • Chronic alcohol use primes bronchial cells for altered inflammatory response and barrier dysfunction during SARS-CoV-2 infection.
    Am J Physiol Lung Cell Mol Physiol Volume: 325 Page(s): L647 - L661
    11/01/2023 Authors: Easley KF; Edenfield RC; Lott MEJ; Reed RC; Das Sarma J; Mehta AJ; Staitieh BS; Lipp EK; Cho IK; Johnson SK
  • Climate Change, Air Quality, and Pulmonary Health Disparities.
    Clin Chest Med Volume: 44 Page(s): 489 - 499
    09/01/2023 Authors: Smirnova N; Shaver AC; Mehta AJ; Philipsborn R; Scovronick N
  • Pioglitazone Reverses Alcohol-Induced Alveolar Macrophage Phagocytic Dysfunction.
    J Immunol Volume: 207 Page(s): 483 - 492
    07/15/2021 Authors: Yeligar SM; Mehta AJ; Harris FL; Brown LAS; Hart CM
  • Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.
    Clin Infect Dis Volume: 72 Page(s): 1247 - 1250
    04/08/2021 Authors: Titanji BK; Farley MM; Mehta A; Connor-Schuler R; Moanna A; Cribbs SK; O'Shea J; DeSilva K; Chan B; Edwards A
  • The historical perspective on pursed lip breathing exercises and its role in pulmonary rehabilitation programs
    Medical research archives Volume: 6
    08/16/2018 Authors: Zhang W; Mehta AJ
  • Alcohol and the Lung.
    Alcohol Res Volume: 38 Page(s): 243 - 254
    01/01/2017 Authors: Mehta AJ; Guidot DM
  • Peroxisome Proliferator-Activated Receptor Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction.
    Am J Respir Cell Mol Biol Volume: 55 Page(s): 35 - 46
    07/01/2016 Authors: Yeligar SM; Mehta AJ; Harris FL; Brown LAS; Hart CM
  • Alcoholism and critical illness: A review.
    World J Crit Care Med Volume: 5 Page(s): 27 - 35
    02/04/2016 Authors: Mehta AJ
  • Chronic Ethanol Exposure Effects on Vitamin D Levels Among Subjects with Alcohol Use Disorder.
    Environ Health Insights Volume: 10 Page(s): 191 - 199
    01/01/2016 Authors: Ogunsakin O; Hottor T; Mehta A; Lichtveld M; McCaskill M
  • Metabolic Consequences of Chronic Alcohol Abuse in Non-Smokers: A Pilot Study.
    PLoS One Volume: 10 Page(s): e0129570
    01/01/2015 Authors: Obianyo O; Liang Y; Burnham EL; Mehta A; Park Y; Uppal K; Harris FL; Jones DP; Brown LAS
  • Treatment With S-Adenosylmethionine And Zinc Restores Nrf2 And Nrf2-Antioxidant Response Element-Dependent Gene Expression In Alcohol-Treated Alveolar Macrophages In Vitro
    Volume: 191
    01/01/2015 Authors: Mehta AJ; Guidot DM
  • Alcohol Use Disorders and the Lung A Clinical and Pathophysiological Approach Preface
    Volume: 14 Page(s): V - VI
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Disruption in the Dynamic Balance Between Transforming Growth Factor-beta and Granulocyte/Macrophage Colony-Stimulating Factor Signaling Within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function
    Volume: 14 Page(s): 155 - 171
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations
    Volume: 14 Page(s): 7 - 10
    01/01/2014 Authors: Guidot DM; Mehta AJ
  • Alcohol-Mediated Zinc Deficiency Within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung
    Volume: 14 Page(s): 173 - 184
    01/01/2014 Authors: Mehta AJ; Guidot DM
  • Pulmonary consequences of alcoholism: A critical review.
    OA Alcohol Volume: 1
    10/01/2013 Authors: Mehta AJ
  • Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction.
    Am J Respir Crit Care Med Volume: 188 Page(s): 716 - 723
    09/15/2013 Authors: Mehta AJ; Yeligar SM; Elon L; Brown LA; Guidot DM
  • Peroxisome Proliferator-Activated Receptor Gamma Activation With Pioglitazone Attenuates Alcohol-Induced Human Alveolar Macrophage Oxidative Stress And Dysfunction
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
    01/01/2013 Authors: Yeligar SM; Mehta AJ; Brown L; Hart M
  • THE PULMONARY COMPLICATIONS OF ALCOHOL ABUSE: COMMON AND DEADLY
    Volume: 36 Page(s): 344A - 344A
    06/01/2012 Authors: Guidot DM; Joshi PC; Mehta AJ; Brown LS
  • Alcohol abuse, the alveolar macrophage and pneumonia.
    Am J Med Sci Volume: 343 Page(s): 244 - 247
    03/01/2012 Authors: Mehta AJ; Guidot DM
  • Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats.
    Alcohol Clin Exp Res Volume: 35 Page(s): 1519 - 1528
    08/01/2011 Authors: Mehta AJ; Joshi PC; Fan X; Brown LAS; Ritzenthaler JD; Roman J; Guidot DM
  • Novel findings from the second wave of adult pH1N1 in the United States.
    Crit Care Med Volume: 38 Page(s): 2059 - 2061
    10/01/2010 Authors: Satterwhite L; Mehta A; Martin GS
  • Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats.
    Am J Respir Cell Mol Biol Volume: 41 Page(s): 207 - 216
    08/01/2009 Authors: Joshi PC; Mehta A; Jabber WS; Fan X; Guidot DM
  • OXIDATIVE STRESS AND ALVEOLAR MACROPHAGE DYSFUNCTION IN THE ALCOHOLIC LUNG
    Volume: 33 Page(s): 289A - 289A
    06/01/2009 Authors: Guidot DM; Mehta AJ; Brown LAS; Joshi PC
  • Zinc Supplementation Restores GM-CSF Signaling in the Alveolar Macrophage and Facilitates Clearance of Klebsiella pneumoniae in the Lungs of Alcohol-Fed Rats
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 179
    01/01/2009 Authors: Mehta AJ; Joshi PC; Fan X; Guidot DM
  • ZINC SUPPLEMENTATION IMPROVES SEVERITY OF KLEBSIELLA PNEUMONIAE PNEUMONIA IN THE SETTING OF CHRONIC ALCOHOL INGESTION IN RATS
    Volume: 57 Page(s): 387 - 388
    01/01/2009 Authors: Mehta AJ; Joshi PC; Guidot DM
  • Chronic alcohol ingestion in rats decreases zinc bioavailability in the alveolar space
    Volume: 32 Page(s): 225A - 225A
    06/01/2008 Authors: Mehta AJ; Guidot DM; Joshi PC
  • Infection-induced modulation of m1 and m2 phenotypes in circulating monocytes: role in immune monitoring and early prognosis of sepsis.
    Shock Volume: 22 Page(s): 423 - 430
    11/01/2004 Authors: Mehta A; Brewington R; Chatterji M; Zoubine M; Kinasewitz GT; Peer GT; Chang ACK; Taylor FB; Shnyra A
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