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Profile

Adam Klein MD

  • Department of Otolaryngology Head and Neck Surgery
    Professor
  • (404) 686-1850
  • aklein4@emory.edu
Head shot of Adam Klein

Overview

Dr. Klein joined the Emory Voice Center in July of 2005 and is its current director. He is a graduate of the University of Connecticut School of Medicine, where he also completed his residency in otolaryngology and head and neck surgery. He then pursued a fellowship in laryngology and care of the professional voice at the Massachusetts General Hospital Center for Laryngeal Surgery and Voice Restoration, at Harvard University. He is an active member of the American Academy of Otolaryngology - Head and Neck Surgery, the American Broncho-Esophagological Association, the Triological Society and the American Laryngological Association. Dr. Klein's clinical specialties include the treatment of laryngeal disorders and the professional voice. His research interests include vocal cord reanimation, laryngeal papillomatosis and designing a surgical trainer for phonomicrosurgery (voice surgery). He has over 50 peer-reviewed publications and is an invited speaker nationally and internationally.

Academic Appointment

  • Professor, Department of Otolaryngology Head and Neck Surgery, Emory University School of Medicine

Education

Degrees

  • BS from Tufts University
  • MD from University of Connecticut School of Medicine

Research

Focus

  • Improving vocal diagnoses and outcomes via integration of advancements in the biomedical and biotechnological sciences. Currently focusing on the issues of vocal fold paralysis and vocal fold reanimation, and the development of a phonomicrosurgical trainer.

Publications

  • Prospective Pilot Study of Second Primary Tumor Prevention With Erlotinib and Celecoxib in Early-Stage Squamous Cell Carcinoma of the Head and Neck: Long-Term Follow-Up.
    Head Neck
    04/28/2025 Authors: Kim P; Saba NF; McCook-Veal A; Liu Y; Klein AM; Beitler JJ; Chen A; Khuri FR; Shin DM
  • Dexamethasone Delivery via Amphiphilic, Low-swelling Hydrogels Treats Postoperative Inflammation in Cervical Spine Applications.
    Adv Healthc Mater Volume: 14 Page(s): e2404292
    03/01/2025 Authors: Linderman SW; Barber GF; DeVeaux SA; Botchwey EA; Refai D; Klein AM; Garca AJ
  • DNA immunotherapy for recurrent respiratory papillomatosis (RRP): phase 1/2 study assessing efficacy, safety, and immunogenicity of INO-3107.
    Nat Commun Volume: 16 Page(s): 1518
    02/12/2025 Authors: Morrow MP; Gillespie E; Sylvester A; Amin MR; Belafsky PC; Best SR; Friedman AD; Klein AM; Lott DG; Mau T
  • A Consensus Statement on the Administration of Systemic Bevacizumab in Patients with Recurrent Respiratory Papillomatosis.
    Laryngoscope Volume: 134 Page(s): 5041 - 5046
    12/01/2024 Authors: Best SR; Bock JM; Fowler NB; Raabe EH; Klein AM; Laetsch TW; McClellan K; Rinkel RNPM; Saba NF; Sidell DR
  • Blood-Based Proteomics for Adult-Onset Focal Dystonias.
    Ann Neurol Volume: 96 Page(s): 110 - 120
    07/01/2024 Authors: Timsina J; Dinasarapu A; Kilic-Berkmen G; Budde J; Sung YJ; Klein AM; Cruchaga C; Jinnah HA
  • Demographics and Clinical Characteristics Associated with the Spread of New-Onset Laryngeal Dystonia.
    Laryngoscope Volume: 134 Page(s): 2295 - 2299
    05/01/2024 Authors: Ghanouni A; Jona N; Jinnah HA; Kilic-Berkmen G; Shelly S; Klein AM
  • Thoracic Duct Occlusion Leading to Intermittent Left Supraclavicular Swelling and Pancreatitis.
    Laryngoscope Volume: 134 Page(s): 1313 - 1315
    03/01/2024 Authors: Jona N; Majdalany BS; Klein AM
  • Efficacy of Systemic Bevacizumab for Recurrent Respiratory Papillomatosis with Pulmonary Involvement.
    Laryngoscope Volume: 134 Page(s): 577 - 581
    02/01/2024 Authors: So RJ; Hidalgo Lopez JC; Ballestas SA; Klein AM; Steuer C; Shin DM; Abousaud M; Teng Y; Saba NF; Tkaczuk AT
  • Interim Results of a Phase 1/2 Open-Label Study of INO-3107 for HPV-6 and/or HPV-11-Associated Recurrent Respiratory Papillomatosis.
    Laryngoscope Volume: 133 Page(s): 3087 - 3093
    11/01/2023 Authors: Mau T; Amin MR; Belafsky PC; Best SR; Friedman AD; Klein AM; Lott DG; Paniello RC; Pransky SM; Saba NF
  • Long-Term Follow-up of Parenteral Bevacizumab In Patients with Recurrent Respiratory Papillomatosis.
    Laryngoscope Volume: 133 Page(s): 2725 - 2733
    10/01/2023 Authors: Ballestas SA; Hidalgo Lopez J; Klein AM; Steuer C; Shin DM; Abousaud M; Schmitt NC; Teng Y; Saba NF; Tkaczuk AT
  • A Comparison of Voice Therapy Attendance Rates Between In-Person and Telepractice.
    Am J Speech Lang Pathol Volume: 32 Page(s): 1154 - 1164
    05/04/2023 Authors: Cutchin GM; Shelly S; Petty B; van Leer E; Tripp RM; Klein AM; Gillespie AI
  • International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
    Int Forum Allergy Rhinol Volume: 13 Page(s): 293 - 859
    04/01/2023 Authors: Wise SK; Damask C; Roland LT; Ebert C; Levy JM; Lin S; Luong A; Rodriguez K; Sedaghat AR; Toskala E
  • Systemic Use of Bevacizumab for Recurrent Respiratory Papillomatosis: Who, What, Where, When, and Why?
    Laryngoscope Volume: 133 Page(s): 2 - 3
    01/01/2023 Authors: Derkay CS; Wikner EE; Pransky S; Best SR; Zur K; Sidell DR; Klein A; Rosen C; Dikkers FG; Johnson R
  • Beauty and Attractiveness in the Human Voice.
    J Voice Volume: 36 Page(s): 507 - 514
    07/01/2022 Authors: Petty BE; Gillespie AI; Shelly S; Klein AM
  • Evaluating Safety of Awake, Bilateral Injection Laryngoplasty for Bilateral Vocal Fold Atrophy.
    J Voice Volume: 35 Page(s): 789 - 792
    09/01/2021 Authors: Kelly Z; Patel AK; Klein AM
  • Virtual interprofessional chronic cough clinic: An efficient and appealing approach to a complex problem.
    Int Forum Allergy Rhinol Volume: 11 Page(s): 1395 - 1398
    09/01/2021 Authors: Kuruvilla M; Hatcher J; Shelly S; Dixit AN; Gillespie AI; VanNostrand K; Saikawa E; Jain A; Klein AM
  • Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.
    Laryngoscope Volume: 131 Page(s): E1941 - E1949
    06/01/2021 Authors: Sidell DR; Balakrishnan K; Best SR; Zur K; Buckingham J; De Alarcon A; Baroody FM; Bock JM; Boss EF; Bower CM
  • Validation of the Communicative Participation Item Bank as an Outcome Measure for Spasmodic Dysphonia.
    Laryngoscope Volume: 131 Page(s): 859 - 864
    04/01/2021 Authors: Yiu Y; Baylor CR; Bamer AM; Shelly S; Klein AM; Garrett CG; Pitman MJ
  • Parenteral Bevacizumab for the Treatment of Severe Respiratory Papillomatosis in an Adult Population.
    Laryngoscope Volume: 131 Page(s): E921 - E928
    03/01/2021 Authors: Tkaczuk A; Trivedi S; Mody MD; Steuer CE; Shin DM; Klein AM; Saba NF
  • Trends in recurrent respiratory papillomatosis treatment.
    Acta Otorrinolaringol Esp (Engl Ed) Volume: 72 Page(s): 109 - 120
    01/01/2021 Authors: Ballestas SA; Shelly S; Soriano RM; Klein A
  • Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck.
    Clin Cancer Res Volume: 26 Page(s): 5860 - 5868
    11/15/2020 Authors: Shin DM; Nannapaneni S; Patel MR; Shi Q; Liu Y; Chen Z; Chen AY; El-Deiry MW; Beitler JJ; Steuer CE
  • IS IT REALLY LARYNGOPHARYNGEAL "REFLUX"? LARYNGEAL SYMPTOMS CORRELATE BETTER WITH DYSPHAGIA AND ARE COMMONLY ASSOCIATED WITH ESOPHAGEAL MOTOR DISORDERS
    Volume: 158 Page(s): S1081 - S1082
    05/01/2020 Authors: Bloch J; Obineme C; Samo S; Godiers ML; Calderon L; Dietz-Lindo KA; Shahnavaz N; Raja S; Keilin S; Cai Q
  • Systemic bevacizumab for the treatment of recurrent respiratory papillomatosis: A retrospective analysis from an academic tertiary care center
    Volume: 30
    10/01/2019 Authors: Trivedi S; Steuer CE; Tkaczuk AT; Shin DM; Klein A; Saba NF
  • Carcinoma presenting as idiopathic anterior glottic webs: A case series.
    Laryngoscope Volume: 129 Page(s): 2118 - 2120
    09/01/2019 Authors: Ramaswamy AT; Tian L; Bock JM; Klein AM; Pitman MJ
  • Phase 1b study of chemoprevention with green tea polyphenon E (PPE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (Erlotinib) in patients (pts) with advanced premalignant (AP) lesions of the head and neck.
    Volume: 37
    05/20/2019 Authors: Shin DM; Beitler JJ; El-Deiry M; Steuer CE; Chen AY; Baddour HM; Chen ZG; Roser S; Magliocca KR; Patel M
  • Simulators for Laryngeal and Airway Surgery.
    Otolaryngol Clin North Am Volume: 50 Page(s): 903 - 922
    10/01/2017 Authors: Burns JA; Adkins LK; Dailey S; Klein AM
  • Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years.
    J Voice Volume: 31 Page(s): 363 - 365
    05/01/2017 Authors: Bradley JP; Barrow EM; Hapner ER; Klein AM; Johns MM
  • Development and validation of a high-fidelity phonomicrosurgical trainer.
    Laryngoscope Volume: 127 Page(s): 888 - 893
    04/01/2017 Authors: Klein AM; Gross J
  • A cost and time analysis of laryngology procedures in the endoscopy suite versus the operating room.
    Laryngoscope Volume: 126 Page(s): 1385 - 1389
    06/01/2016 Authors: Hillel AT; Ochsner MC; Johns MM; Klein AM
  • Bacterial Laryngotracheitis and Associated Upper Airway Obstruction: A Case Series.
    Ann Otol Rhinol Laryngol Volume: 124 Page(s): 1002 - 1005
    12/01/2015 Authors: Gross JH; Giraldez-Rodriguez LA; Klein AM
  • Diagnostic Delays in Spasmodic Dysphonia: A Call for Clinician Education.
    J Voice Volume: 29 Page(s): 592 - 594
    09/01/2015 Authors: Creighton FX; Hapner E; Klein A; Rosen A; Jinnah HA; Johns MM
  • Voice Outcomes Following Posterior Cordotomy With Medial Arytenoidectomy in Patients With Bilateral Vocal Fold Immobility.
    JAMA Otolaryngol Head Neck Surg Volume: 141 Page(s): 728 - 732
    08/01/2015 Authors: Hillel AT; Giraldez L; Samad I; Gross J; Klein AM; Johns MM
  • The utility of narrow band imaging in the treatment of laryngeal papillomatosis in awake patients.
    J Voice Volume: 29 Page(s): 349 - 351
    05/01/2015 Authors: Ochsner MC; Klein AM
  • Phoniatrics.
    Biomed Res Int Volume: 2015 Page(s): 156014
    01/01/2015 Authors: Oguz H; Hess M; Klein AM
  • Validation of a telephone screening tool for spasmodic dysphonia and vocal fold tremor.
    J Voice Volume: 28 Page(s): 711 - 715
    11/01/2014 Authors: Johnson DM; Hapner ER; Klein AM; Pethan M; Johns MM
  • Preliminary data on two voice therapy interventions in the treatment of presbyphonia.
    Laryngoscope Volume: 124 Page(s): 1869 - 1876
    08/01/2014 Authors: Ziegler A; Verdolini Abbott K; Johns M; Klein A; Hapner ER
  • Laryngeal papillomatosis associated dysplasia in the adult population: an update on prevalence and HPV subtyping.
    Ann Otol Rhinol Laryngol Volume: 123 Page(s): 402 - 408
    06/01/2014 Authors: Davids T; Muller S; Wise JC; Johns MM; Klein A
  • The role of laryngoscopy in the diagnosis of spasmodic dysphonia.
    JAMA Otolaryngol Head Neck Surg Volume: 140 Page(s): 228 - 232
    03/01/2014 Authors: Daraei P; Villari CR; Rubin AD; Hillel AT; Hapner ER; Klein AM; Johns MM
  • Assessment of phonomicrosurgical training in otolaryngology residencies: a resident survey.
    Laryngoscope Volume: 123 Page(s): 1474 - 1477
    06/01/2013 Authors: Shah MD; Johns MM; Statham M; Klein AM
  • Voice outcomes from subligamentous cordectomy for early glottic cancer.
    Ann Otol Rhinol Laryngol Volume: 122 Page(s): 190 - 196
    03/01/2013 Authors: Hillel AT; Johns MM; Hapner ER; Shah M; Wise JC; Klein AM
  • Computed tomography has low yield in the evaluation of idiopathic unilateral true vocal fold paresis.
    Laryngoscope Volume: 123 Page(s): 204 - 207
    01/01/2013 Authors: Badia PI; Hillel AT; Shah MD; Johns MM; Klein AM
  • Methicillin-resistant and methicillin-sensitive Staphylococcus aureus laryngitis.
    Laryngoscope Volume: 122 Page(s): 2497 - 2502
    11/01/2012 Authors: Shah MD; Klein AM
  • Coprevalence of anxiety and depression with spasmodic dysphonia: a case-control study.
    J Voice Volume: 26 Page(s): 667.e1 - 667.e6
    09/01/2012 Authors: White LJ; Hapner ER; Klein AM; Delgaudio JM; Hanfelt JJ; Jinnah HA; Johns MM
  • The management of postintubation phonatory insufficiency.
    J Voice Volume: 26 Page(s): 530 - 533
    07/01/2012 Authors: Arviso LC; Klein AM; Johns MM
  • Current dysphonia trends in patients over the age of 65: is vocal atrophy becoming more prevalent?
    Laryngoscope Volume: 122 Page(s): 332 - 335
    02/01/2012 Authors: Davids T; Klein AM; Johns MM
  • Coprevalence of tremor with spasmodic dysphonia: a case-control study.
    Laryngoscope Volume: 121 Page(s): 1752 - 1755
    08/01/2011 Authors: White LJ; Klein AM; Hapner ER; Delgaudio JM; Hanfelt JJ; Jinnah HA; Johns MM
  • Papillary squamous cell carcinoma of the larynx.
    Ear Nose Throat J Volume: 90 Page(s): E13 - E15
    08/01/2011 Authors: Colby C; Klein AM
  • Association of asthma with clinically aggressive recurrent respiratory papillomatosis.
    Arch Otolaryngol Head Neck Surg Volume: 137 Page(s): 368 - 372
    04/01/2011 Authors: Robb PK; Weinberger PM; Perakis H; Li A; Klein AM; Johns MM; Adkins LK; Postma GN
  • Long-term outcomes of injection laryngoplasty in patients with potentially recoverable vocal fold paralysis.
    Laryngoscope Volume: 120 Page(s): 2237 - 2240
    11/01/2010 Authors: Arviso LC; Johns MM; Mathison CC; Klein AM
  • Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy.
    J Clin Oncol Volume: 28 Page(s): 2318 - 2322
    05/10/2010 Authors: Beitler JJ; Muller S; Grist WJ; Corey A; Klein AM; Johns MM; Perkins CL; Davis LW; Udayasanker U; Landry JC
  • Analysis of voice change during cellular phone use: a blinded controlled study.
    J Voice Volume: 24 Page(s): 308 - 313
    05/01/2010 Authors: Shewmaker MB; Hapner ER; Gilman M; Klein AM; Johns MM
  • Assessing the effectiveness of botulinum toxin injections for adductor spasmodic dysphonia: clinician and patient perception.
    J Voice Volume: 24 Page(s): 242 - 249
    03/01/2010 Authors: Braden MN; Johns MM; Klein AM; Delgaudio JM; Gilman M; Hapner ER
  • Comparison of outcomes and complications between awake and asleep injection laryngoplasty: a case-control study.
    Laryngoscope Volume: 119 Page(s): 1417 - 1423
    07/01/2009 Authors: Mathison CC; Villari CR; Klein AM; Johns MM
  • Performer's attitudes toward seeking health care for voice issues: understanding the barriers.
    J Voice Volume: 23 Page(s): 225 - 228
    03/01/2009 Authors: Gilman M; Merati AL; Klein AM; Hapner ER; Johns MM
  • Muscle Surface Recording and Stimulation Using Integrated PDMS-Based Microelectrode Arrays: Recording-Triggered Stimulation for Prosthetic Purposes
    Page(s): 96 - +
    01/01/2009 Authors: Guo L; Kitashima LJ; Villari CR; Klein AM; DeWeerth SP
  • Spontaneous resolution of hemorrhagic polyps of the true vocal fold.
    J Voice Volume: 23 Page(s): 132 - 135
    01/01/2009 Authors: Klein AM; Lehmann M; Hapner ER; Johns MM
  • Validation of a laryngeal dissection module for phonomicrosurgical training.
    Laryngoscope Volume: 119 Page(s): 211 - 215
    01/01/2009 Authors: Contag SP; Klein AM; Blount AC; Johns MM
  • Comparison of an oropharyngeal pH probe and a standard dual pH probe for diagnosis of laryngopharyngeal reflux.
    Ann Otol Rhinol Laryngol Volume: 118 Page(s): 1 - 5
    01/01/2009 Authors: Golub JS; Johns MM; Lim JH; DelGaudio JM; Klein AM
  • Vocal outcome measures after bilateral posterior cricoarytenoid muscle botulinum toxin injections for abductor spasmodic dysphonia.
    Otolaryngol Head Neck Surg Volume: 139 Page(s): 421 - 423
    09/01/2008 Authors: Klein AM; Stong BC; Wise J; DelGaudio JM; Hapner ER; Johns MM
  • A rare cause of dysphonia.
    Ear Nose Throat J Volume: 87 Page(s): E09
    08/01/2008 Authors: Naseri I; Wise SK; Klein AM
  • Voice therapy improves quality of life in age-related dysphonia: a case-control study.
    J Voice Volume: 22 Page(s): 70 - 74
    01/01/2008 Authors: Berg EE; Hapner E; Klein A; Johns MM
  • Vocal emergencies.
    Otolaryngol Clin North Am Volume: 40 Page(s): 1063 - vii
    10/01/2007 Authors: Klein AM; Johns MM
  • Pathology quiz case 1. Laryngeal myxoma.
    Arch Otolaryngol Head Neck Surg Volume: 133 Page(s): 94 - 96
    01/01/2007 Authors: Leu G; Klein AM; Deyrup AT; Johns MM
  • Imaging the human vocal folds in vivo with optical coherence tomography: a preliminary experience.
    Ann Otol Rhinol Laryngol Volume: 115 Page(s): 277 - 284
    04/01/2006 Authors: Klein AM; Pierce MC; Zeitels SM; Anderson RR; Kobler JB; Shishkov M; de Boer JF
  • Polyglycolic acid/poly-L-lactic acid copolymer use in laryngotracheal reconstruction: a rabbit model.
    Laryngoscope Volume: 115 Page(s): 583 - 587
    04/01/2005 Authors: Klein AM; Graham VL; Gulleth Y; Lafreniere D
  • Malignant mimickers: chronic bacterial and fungal infections of the larynx.
    J Voice Volume: 19 Page(s): 151 - 157
    03/01/2005 Authors: Klein AM; Tiu C; Lafreniere D
  • Inflammatory myofibroblastic tumor in the neonate: a case report.
    Otolaryngol Head Neck Surg Volume: 128 Page(s): 145 - 147
    01/01/2003 Authors: Klein AM; Schoem SR; Altman A; Eisenfeld L
  • Histoplasmosis of the larynx: a case report.
    Ear Nose Throat J Volume: 81 Page(s): 309 - 310
    05/01/2002 Authors: Klein AM; Spiro J; Lafreniere D
  • Unrecognized aspiration of a dental retainer: a case report.
    Otolaryngol Head Neck Surg Volume: 126 Page(s): 438 - 439
    04/01/2002 Authors: Klein AM; Schoem SR
  • Growth-related oncogene-alpha expression in human nasal polyps.
    Otolaryngol Head Neck Surg Volume: 123 Page(s): 85 - 90
    07/01/2000 Authors: Klein AM; Anderson K; Lafreniere D; Leonard G; Kreutzer D
  • Enterocutaneous fistula as a postoperative complication of laparoscopic inguinal hernia repair.
    Surg Laparosc Endosc Volume: 9 Page(s): 60 - 62
    01/01/1999 Authors: Klein AM; Banever TC
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