Ahsan Husain
Academic Appointment
- Professor, Department of Medicine, Emory University
Education
Degrees
- PhD from University of Nottingham
- BSc from
Research
Focus
- My investigations focus on 3 areas of research. I identified a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. Over the last 20 years, I have studied its angiotensin II-dependent effects in experimental models of cardiovascular disease. Fourteen years ago, I co-pioneered the use of ancestral protein reconstruction (molecular paleontology). I have used this technique and site-directed mutagenesis to study the evolution of function in enzymes.
Publications
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Br J Pharmacol Volume: 180 Suppl 2 Page(s): S23 - S144
10/01/2023 Authors: Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD -
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
Volume: 147 Page(s): 1823 - 1842
06/13/2023 Authors: Cho K-W; Andrade M; Bae S; Kim S; Eyun Kim J; Jang EY; Lee S; Husain A; Sutliff RL; Calvert JW -
Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts.
J Mol Cell Cardiol Volume: 170 Page(s): 47 - 59
09/01/2022 Authors: Nicks AM; Holman SR; Chan AY; Tsang M; Young PE; Humphreys DT; Naqvi N; Husain A; Li M; Smith NJ -
Remuscularization with triiodothyronine and 1-blocker therapy reverses post-ischemic left ventricular dysfunction and adverse remodeling.
Sci Rep Volume: 12 Page(s): 8852
05/25/2022 Authors: Bogush N; Tan L; Naqvi E; Calvert JW; Graham RM; Taylor WR; Naqvi N; Husain A -
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
Br J Pharmacol Volume: 178 Suppl 1 Page(s): S27 - S156
10/01/2021 Authors: Alexander SP; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD -
Mechanism-Based Cardiac Regeneration Strategies in Mammals.
Front Cell Dev Biol Volume: 9 Page(s): 747842
01/01/2021 Authors: Naqvi N; Iismaa SE; Graham RM; Husain A -
Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts.
Theranostics Volume: 11 Page(s): 4790 - 4808
01/01/2021 Authors: Tan L; Bogush N; Naqvi E; Calvert JW; Graham RM; Taylor WR; Naqvi N; Husain A -
DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling.
Sci Rep Volume: 10 Page(s): 21918
12/14/2020 Authors: Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM -
Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes.
Sci Rep Volume: 10 Page(s): 15318
09/18/2020 Authors: Nicks AM; Kesteven SH; Li M; Wu J; Chan AY; Naqvi N; Husain A; Feneley MP; Smith NJ; Iismaa SE -
Role of DJ-1 in Modulating Glycative Stress in Heart Failure.
J Am Heart Assoc Volume: 9 Page(s): e014691
02/18/2020 Authors: Shimizu Y; Nicholson CK; Polavarapu R; Pantner Y; Husain A; Naqvi N; Chin L-S; Li L; Calvert JW