School of Medicine Homepage
Emory University Shield
  • About
    • Our Vision
    • Academic Departments
    • Our Leadership
    • Health Care Partnerships
    • Diversity, Equity, & Inclusion
    • Location
    • Supporting Our People
    • Our Faculty
    • History
    • News
    • Events
    • Contact Us
  • Education
    • Degree and Certificate Programs
    • Academic Departments
    • Residents & Fellows
    • Postdoctoral Training
    • Continuing Medical Education
    • Admissions
    • Cost and Financial Aid
    • Student Resources
  • Research
    • Research Innovation
    • Conducting Research
    • Core Facilities
    • Research Centers
    • Research Training
    • Academic Departments
    • Find a Researcher
    • Research News
  • Clinical Experience
    • Where We Work
    • Caring for a Diverse Population
    • Faculty Clinical Experience
    • Advanced Patient Care
    • Academic Departments
    • Community Learning
  • Giving
  • Directory

Directory section navigation

  • Faculty Profiles

Emory University School of Medicine

  • About
    • Sub link
      Our Vision
    • Sub link
      Academic Departments
    • Sub link
      Our Leadership
    • Sub link
      Health Care Partnerships
    • Sub link
      Diversity, Equity, & Inclusion
    • Sub link
      Location
    • Sub link
      Supporting Our People
    • Sub link
      Our Faculty
    • Sub link
      History
    • Sub link
      News
    • Sub link
      Events
    • Sub link
      Contact Us
  • Education
    • Sub link
      Degree and Certificate Programs
    • Sub link
      Academic Departments
    • Sub link
      Residents & Fellows
    • Sub link
      Postdoctoral Training
    • Sub link
      Continuing Medical Education
    • Sub link
      Admissions
    • Sub link
      Cost and Financial Aid
    • Sub link
      Student Resources
  • Research
    • Sub link
      Research Innovation
    • Sub link
      Conducting Research
    • Sub link
      Core Facilities
    • Sub link
      Research Centers
    • Sub link
      Research Training
    • Sub link
      Academic Departments
    • Sub link
      Find a Researcher
    • Sub link
      Research News
  • Clinical Experience
    • Sub link
      Where We Work
    • Sub link
      Caring for a Diverse Population
    • Sub link
      Faculty Clinical Experience
    • Sub link
      Advanced Patient Care
    • Sub link
      Academic Departments
    • Sub link
      Community Learning
  • Giving
  • Directory
  • Home School of Medicine Home
  • Directory

Profile

Andrew Hong

  • SOM: Peds: Solid Tumor
    Assistant Professor
  • (404) 727-3720
  • andrew.hong2@emory.edu
  • Laboratory
  • Emory University School of Medicine
    Pediatrics
    1760 Haygood Drive NE, HSRB 370
Head shot of Andrew Hong

Overview

Andrew Hong, MD, joined Childrens Healthcare of Atlanta and Emory University School of Medicine as an Assistant Professor of Pediatrics with an Endowed Invesitgatorship in March 2020. He came to Atlanta, Ga., from Boston, Mass., where he was on the faculty at Dana-Farber/Boston Childrens Cancer and Blood Disorders Center as an instructor of pediatrics.

Prior to being a faculty member, Dr. Hong earned his undergraduate degree from the University of Chicago. He was recruited by McKinsey & Company as a business analyst. After several years, Dr. Hong received a Post-Baccalaureate Intramural Research Training Award from the National Cancer Institute (NCI) to perform yeast genomics under Munira Basrai, PhD, at the Center for Cancer Research. He returned to The University of Chicago Pritzker School of Medicine, where he earned his medical degree. While in medical school, his research focused on studying sirtuins under Raul Mostoslavsky, MD, PhD; David Lombard, PhD; and Frederick Alt, PhD, at Boston Childrens Hospital, studying breast cancer risk under Funmi Olopade, MD, at The University of Chicago.

Dr. Hong completed his pediatrics internship and residency at Boston Childrens Hospital and Boston Medical Center. He then completed a fellowship in pediatric hematology and oncology at the Dana-Farber/Boston Childrens Cancer and Blood Disorders Center. Afterwards, Dr. Hong became an instructor in pediatrics at Harvard Medical School, while also completing his post-doctoral fellowship under William C. Hahn, MD, PhD, at the Dana-Farber/Boston Childrens Cancer and Blood Disorders Center, Broad Institute and Massachusetts Institute of Technology.

Dr. Hong has broad clinical experience across pediatric oncology. His research (thehonglab.org) is focused on high-risk solid tumors (e.g., kidney cancers, soft tissue sarcomas and brain tumors). These cancers represent the areas of greatest need in pediatric oncology. His work uses functional genomic techniques (e.g., RNAi and CRISPR-Cas9) and the latest sequencing technologies (e.g., long-range phased sequencing, scRNAseq and ATACseq) to identify new therapeutics and mechanisms in pediatric cancers.

His work has been funded by several groups, such as the National Cancer Institute (NCI), U.S. Department of Defense, American Cancer Society, American Association for Cancer Research, CureSearch for Childrens Cancer, Alexs Lemonade Stand Foundation and Cure ATRT.

Academic Appointment

  • Assistant Professor, Pediatrics, Emory University School of Medicine
  • Assistant Professor, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta

Education

Degrees

  • MD from University of Chicago

Research

Publications

  • SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

    03/26/2025 Authors: Cooper GW; Lee BP; Kim WJ; Su Y; Chen VZ; Salas E; Yang X; Lintner RE; Piccioni F; Giacomelli AO
  • Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.
    NAR Cancer Volume: 7 Page(s): zcaf002
    03/01/2025 Authors: Sad K; Fawwal DV; Jones CY; Hill EJ; Skinner KT; Adams ML; Lustenberger S; Lee RS; Lohano SV; Elayavalli SR
  • Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers.
    Nat Rev Urol
    01/29/2025 Authors: Perotti D; O'Sullivan MJ; Walz AL; Davick J; Al-Saadi R; Benedetti DJ; Brzezinski J; Ciceri S; Cost NG; Dome JS
  • Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
    bioRxiv
    10/25/2024 Authors: Kwon JJ; Dilly J; Liu S; Kim E; Bian Y; Dharmaiah S; Tran TH; Kapner KS; Ly SH; Yang X
  • Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype.
    bioRxiv
    08/01/2024 Authors: Sad K; Jones CY; Fawwal DV; Hill EJ; Skinner K; Lustenberger S; Lee RS; Elayavalli SR; Farhi J; Lemon LD
  • Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
    Commun Biol Volume: 7 Page(s): 426
    04/08/2024 Authors: Mittal K; Cooper GW; Lee BP; Su Y; Skinner KT; Shim J; Jonus HC; Kim WJ; Doshi M; Almanza D
  • Hallmark discoveries in the biology of Wilms tumour.
    Nat Rev Urol Volume: 21 Page(s): 158 - 180
    03/01/2024 Authors: Perotti D; Williams RD; Wegert J; Brzezinski J; Maschietto M; Ciceri S; Gisselsson D; Gadd S; Walz AL; Furtwaengler R
  • Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q.
    Nat Commun Volume: 14 Page(s): 8006
    12/18/2023 Authors: Murphy AJ; Cheng C; Williams J; Shaw TI; Pinto EM; Dieseldorff-Jones K; Brzezinski J; Renfro LA; Tornwall B; Huff V
  • Children's Oncology Group's 2023 blueprint for research: Renal tumors.
    Pediatr Blood Cancer Volume: 70 Suppl 6 Page(s): e30586
    09/01/2023 Authors: Geller JI; Hong AL; Vallance KL; Evageliou N; Aldrink JH; Cost NG; Treece AL; Renfro LA; Mullen EA; COG Renal Tumor Committee
  • Genetics of ABCB1 in Cancer.
    Cancers (Basel) Volume: 15
    08/24/2023 Authors: Skinner KT; Palkar AM; Hong AL
  • The tumor microenvironment and immune targeting therapy in pediatric renal tumors.
    Pediatr Blood Cancer Volume: 70 Suppl 2 Page(s): e30110
    05/01/2023 Authors: Hont AB; Dumont B; Sutton KS; Anderson J; Kentsis A; Drost J; Hong AL; Verschuur A
  • The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study.
    Res Sq
    03/16/2023 Authors: Murphy AJ; Cheng C; Williams J; Shaw TI; Pinto EM; Dieseldorff-Jones K; Brzezinski J; Renfro LA; Tornwall B; Huff V
  • Inflammation or Infiltration? Infiltrative Cardiovascular Chloroma Presenting With Syncope and Heart Block.
    Circ Cardiovasc Imaging Volume: 16 Page(s): e014532
    01/01/2023 Authors: Wilson HC; Hashemi S; Sabnis HS; Hong AL; Michelfelder EC
  • Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation Rescues Marrow Failure From Acute Leukemia Therapy in a Patient With Previously Undiagnosed Ligase IV Syndrome.
    J Pediatr Hematol Oncol Volume: 45 Page(s): e139 - e141
    01/01/2023 Authors: Fridlyand DM; Chandrakasan S; Aljudi A; Aumann WK; Westfall E; Kirwan B; Bryson EW; Keller FG; Arnold SD; Hong AL
  • Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor-positive Breast Cancer.
    Cancer Res Commun Volume: 2 Page(s): 1569 - 1578
    12/01/2022 Authors: Jones RB; Farhi J; Adams M; Parwani KK; Cooper GW; Zecevic M; Lee RS; Hong AL; Spangle JM
  • IMPACT OF BIOMARKERS ON OUTCOME IN STAGE I AND II LOW RISK FAVORABLE HISTOLOGY WILMS TUMORS. A REPORT FROM THE CHILDREN'S ONCOLOGY GROUP AREN03B2 PROTOCOL
    Volume: 69
    11/01/2022 Authors: Vallance K; Renfro L; Evageliou N; Benedetti D; Perlman E; Cost N; Hong A; Sutton K; Geller J; Ehrlich P
  • SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities.
    Cancers (Basel) Volume: 14
    07/27/2022 Authors: Cooper GW; Hong AL
  • Recent Advances in Renal Medullary Carcinoma.
    Int J Mol Sci Volume: 23
    06/26/2022 Authors: Su Y; Hong AL
  • SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.
    Cell Rep Volume: 36 Page(s): 109443
    07/27/2021 Authors: Dai C; Rennhack JP; Arnoff TE; Thaker M; Younger ST; Doench JG; Huang AY; Yang A; Aguirre AJ; Wang B
  • Haplotype-resolved germline and somatic alterations in renal medullary carcinomas.
    Genome Med Volume: 13 Page(s): 114
    07/14/2021 Authors: Tan K-T; Kim H; Carrot-Zhang J; Zhang Y; Kim WJ; Kugener G; Wala JA; Howard TP; Chi Y-Y; Beroukhim R
  • Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
    Cell Rep Volume: 36 Page(s): 109367
    07/13/2021 Authors: Neggers JE; Paolella BR; Asfaw A; Rothberg MV; Skipper TA; Yang A; Kalekar RL; Krill-Burger JM; Dharia NV; Kugener G
  • HSCT RESCUES MARROW FAILURE IN A PATIENT WITH LEUKEMIA AND PREVIOUSLY UNDIAGNOSED LIGASE IV SYNDROME
    Volume: 68 Page(s): S184 - S185
    06/01/2021 Authors: Fridlyand D; Chandrakasan S; Aljudi A; Aumann W; Westfall E; Kirwan B; Bryson E; Keller F; Arnold S; Hong A
  • HSCT RESCUES MARROW FAILURE IN A PATIENT WITH LEUKEMIA AND PREVIOUSLY UNDIAGNOSED LIGASE IV SYNDROME
    Volume: 68 Page(s): S198 - S199
    06/01/2021 Authors: Fridlyand DM; Chandrakasan S; Aljudi A; Aumann W; Westfall E; Kirwan B; Bryson EW; Keller FG; Arnold SD; Hong AL
  • A first-generation pediatric cancer dependency map.
    Nat Genet Volume: 53 Page(s): 529 - 538
    04/01/2021 Authors: Dharia NV; Kugener G; Guenther LM; Malone CF; Durbin AD; Hong AL; Howard TP; Bandopadhayay P; Wechsler CS; Fung I
  • Progress Update in Pediatric Renal Tumors.
    Curr Oncol Rep Volume: 23 Page(s): 33
    02/16/2021 Authors: Jain J; Sutton KS; Hong AL
  • Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
    Cell Rep Volume: 33 Page(s): 108493
    12/15/2020 Authors: Neggers JE; Paolella BR; Asfaw A; Rothberg MV; Skipper TA; Yang A; Kalekar RL; Krill-Burger JM; Dharia NV; Kugener G
  • Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine.
    Clin Cancer Res Volume: 26 Page(s): 4995 - 5006
    09/15/2020 Authors: Howard TP; Oberlick EM; Rees MG; Arnoff TE; Pham M-T; Brenan L; DoCarmo M; Hong AL; Kugener G; Chou H-C
  • Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use.
    Pediatr Blood Cancer Volume: 67 Page(s): e28326
    09/01/2020 Authors: Pinches RS; Clinton CM; Ward A; Meyer SC; Al-Ibraheemi A; Forrest SJ; Strand GR; Detert H; Piche-Schulman A; Gill K
  • A systematic approach to create patient-derived models of rare tumors.
    Volume: 80 Page(s): 28 - 28
    06/01/2020 Authors: Tseng Y-Y; Keskula P; Deasy R; Hong A; Chatterji P; Vazquez F; Bass A; Van Hare B; Sandak D; Ligon K
  • CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer.
    Cell Rep Volume: 29 Page(s): 2355 - 2370.e6
    11/19/2019 Authors: Hwang JH; Seo J-H; Beshiri ML; Wankowicz S; Liu D; Cheung A; Li J; Qiu X; Hong AL; Botta G
  • Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
    Nat Commun Volume: 10 Page(s): 2400
    06/03/2019 Authors: Bandopadhayay P; Piccioni F; O'Rourke R; Ho P; Gonzalez EM; Buchan G; Qian K; Gionet G; Girard E; Coxon M
  • MCL1 and DEDD Promote Urothelial Carcinoma Progression.
    Mol Cancer Res Volume: 17 Page(s): 1294 - 1304
    06/01/2019 Authors: Hong AL; Guerriero JL; Doshi MB; Kynnap BD; Kim WJ; Schinzel AC; Modiste R; Schlauch AJ; Adam RM; Kwiatkowski DJ
  • Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
    Cell Metab Volume: 29 Page(s): 1166 - 1181.e6
    05/07/2019 Authors: Harris IS; Endress JE; Coloff JL; Selfors LM; McBrayer SK; Rosenbluth JM; Takahashi N; Dhakal S; Koduri V; Oser MG
  • MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors.
    Cancer Res Volume: 79 Page(s): 2404 - 2414
    05/01/2019 Authors: Howard TP; Arnoff TE; Song MR; Giacomelli AO; Wang X; Hong AL; Dharia NV; Wang S; Vazquez F; Pham M-T
  • Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
    Elife Volume: 8
    03/12/2019 Authors: Hong AL; Tseng Y-Y; Wala JA; Kim W-J; Kynnap BD; Doshi MB; Kugener G; Sandoval GJ; Howard TP; Li J
  • Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
    Clin Genitourin Cancer Volume: 17 Page(s): 1 - 6
    02/01/2019 Authors: Msaouel P; Hong AL; Mullen EA; Atkins MB; Walker CL; Lee C-H; Carden MA; Genovese G; Linehan WM; Rao P
  • An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.
    Elife Volume: 7
    07/30/2018 Authors: Li J; Choi PS; Chaffer CL; Labella K; Hwang JH; Giacomelli AO; Kim JW; Ilic N; Doench JG; Ly SH
  • Defining a pediatric cancer dependency map
    Volume: 78
    07/01/2018 Authors: Dharia NV; Malone C; Iniguez AB; Guenther L; Chen L; Alexe G; Durbin AD; Zimmerman MW; Hong A; Bandopadhayay P
  • Expanding tumor chemical-genetic interaction map using next-generation cancer models
    Volume: 16
    10/01/2017 Authors: Tseng Y-YM; Hong A; Gill S; Keskula P; Raghavan S; Cheah J; Tsherniak A; Vazquez F; Alkhairy S; Peng A
  • Genome-scale ORF screening to identify modulators of the epithelial-to-mesenchymal transition
    Volume: 16
    10/01/2017 Authors: Li J; Choi P; Chaffer C; Labella K; Kim JW; Doench J; Dai C; Giacomelli A; Ly SH; Hwang J
  • Emerging Opportunities for Target Discovery in Rare Cancers.
    Cell Chem Biol Volume: 24 Page(s): 1075 - 1091
    09/21/2017 Authors: Sharifnia T; Hong AL; Painter CA; Boehm JS
  • Renal Medullary Carcinoma: Establishing Standards in Practice.
    J Oncol Pract Volume: 13 Page(s): 414 - 421
    07/01/2017 Authors: Beckermann KE; Sharma D; Chaturvedi S; Msaouel P; Abboud MR; Allory Y; Bourdeaut F; Calderaro J; de Cubas AA; Derebail VK
  • Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models
    Volume: 77
    07/01/2017 Authors: Tseng Y-Y; Hong A; Keskula P; Gill S; Cheah J; Kryukov G; Tsherniak A; Vazquez F; Cowley G; Alkhairy S
  • Integrated genetic and pharmacologic interrogation of rare cancers.
    Nat Commun Volume: 7 Page(s): 11987
    06/22/2016 Authors: Hong AL; Tseng Y-Y; Cowley GS; Jonas O; Cheah JH; Kynnap BD; Doshi MB; Oh C; Meyer SC; Church AJ
  • Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.
    JAMA Oncol Volume: 2 Page(s): 608 - 615
    05/01/2016 Authors: Harris MH; DuBois SG; Glade Bender JL; Kim A; Crompton BD; Parker E; Dumont IP; Hong AL; Guo D; Church A
  • Functional Genomic Characterization of Cancer Genomes.
    Cold Spring Harb Symp Quant Biol Volume: 81 Page(s): 237 - 246
    01/01/2016 Authors: Howard TP; Vazquez F; Tsherniak A; Hong AL; Rinne M; Aguirre AJ; Boehm JS; Hahn WC
  • UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women.
    Drug Metab Dispos Volume: 35 Page(s): 1254 - 1261
    08/01/2007 Authors: Hong AL; Huo D; Kim H-J; Niu Q; Fackenthal DL; Cummings SA; John EM; West DW; Whittemore AS; Das S
  • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
    Cell Volume: 124 Page(s): 315 - 329
    01/27/2006 Authors: Mostoslavsky R; Chua KF; Lombard DB; Pang WW; Fischer MR; Gellon L; Liu P; Mostoslavsky G; Franco S; Murphy MM
  • The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.
    Genetics Volume: 170 Page(s): 509 - 517
    06/01/2005 Authors: Kastenmayer JP; Lee MS; Hong AL; Spencer FA; Basrai MA
Read more publications Fewer publications
Directory
  • Faculty Profiles
Emory University Homepage

Contact & Location

Emory University School of Medicine
100 Woodruff Circle
Atlanta, GA  30322 USA
  • Contact Us
  • Maps & Directions
  • Careers

Information For

  • Alumni
  • Faculty & Staff
  • Patients
  • Residents & Fellows
  • Students
Support the School of Medicine School of Medicine Intranet
facebook facebook twitter twitter linkedin linkedin instagram instagram youtube youtube
© 2025 Emory University
  • Privacy Policy
  • Emergency Information
  • EEO Employer-Disability/Veteran Statements