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Profile

Adam Gracz

  • Department of Medicine
    Assistant Professor
  • (404) 727-0616
  • adam.gracz@emory.edu
  • Website
Head shot of Adam Gracz

Academic Appointment

  • Assistant Professor, Medicine - Digestive Diseases, Emory University

Education

Degrees

  • Ph.D. from University of North Carolina at Chapel Hill
  • M.S. from University of North Carolina at Chapel Hill
  • B.A. from University of North Carolina at Chapel Hill

Research

Publications

  • Tet1 safeguards lineage allocation in intestinal stem cells.
    bioRxiv
    05/13/2025 Authors: Gleizes A; Janto NV; Bombin S; Rao V; Ari G; Sun S; Fonseca M; Gracz AD
  • Tritrichomonas muris sensitizes the intestinal epithelium to doxorubicin-induced apoptosis.
    Am J Physiol Gastrointest Liver Physiol Volume: 328 Page(s): G594 - G609
    05/01/2025 Authors: Janto NV; Gleizes AR; Sun SJ; Ari G; Rao V; Gracz AD
  • Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis.
    Nat Commun Volume: 16 Page(s): 1667
    02/15/2025 Authors: Hrncir HR; Goodloe B; Bombin S; Hogan CB; Jadi O; Gracz AD
  • Lgr5 + intestinal stem cells are required for organoid survival after genotoxic injury.
    Development Volume: 151
    12/01/2024 Authors: Lee J; Gleizes A; Janto NV; Appell LL; Sun S; Takaesu F; Webster SF; Hailstock T; Barker N; Gracz AD
  • Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8+ intraepithelial T cells.
    Mucosal Immunol Volume: 17 Page(s): 1301 - 1313
    12/01/2024 Authors: Rodriguez-Marino N; Royer CJ; Rivera-Rodriguez DE; Seto E; Gracien I; Jones RM; Scharer CD; Gracz AD; Cervantes-Barragan L
  • Tritrichomonas muris sensitizes the intestinal epithelium to doxorubicin-induced apoptosis.
    bioRxiv
    08/09/2024 Authors: Janto NV; Gleizes AR; Sun S; Ari G; Gracz AD
  • Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury.
    bioRxiv
    04/25/2024 Authors: Lee J; Gleizes A; Takaesu F; Webster SF; Hailstock T; Barker N; Gracz AD
  • Sox9 links biliary maturation to branching morphogenesis.
    bioRxiv
    01/16/2024 Authors: Hrncir HR; Bombin S; Goodloe B; Hogan CB; Jadi O; Gracz AD
  • Panic at the Bile Duct: How Intrahepatic Cholangiocytes Respond to Stress and Injury.
    Am J Pathol Volume: 193 Page(s): 1440 - 1454
    10/01/2023 Authors: Hrncir HR; Hantelys F; Gracz AD
  • SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release.
    Biomolecules Volume: 13
    01/20/2023 Authors: Balasubramaniam A; Tedbury PR; Mwangi SM; Liu Y; Li G; Merlin D; Gracz AD; He P; Sarafianos SG; Srinivasan S
  • ENTERIC NEURONAL VASOACTIVE INTESTINAL PEPTIDE MEDIATES SARS-COV-2 ASSOCIATED DIARRHEA
    Volume: 162 Page(s): S364 - S364
    05/01/2022 Authors: Balasubramaniam A; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; He P; Srinivasan S
  • SARS-CoV-2 induces enteric neuronal production of vasoactive intestinal peptide as a potential mechanism of COVID-19-associated diarrhea
    Volume: 33
    08/01/2021 Authors: He P; Tedbury PR; Gracz A; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
  • SARS-COV-2 INDUCES EPITHYELIAL-NEURONAL CROSSTALK STIMULATING VASOACTIVE INTESTINAL PEPTIDE RELEASE AS A POTENTIAL MECHANISM OF COVID-19-ASSOCIATED DIARRHEA
    Volume: 160 Page(s): S233 - S234
    05/01/2021 Authors: He P; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
  • Sox9EGFP Defines Biliary Epithelial Heterogeneity Downstream of Yap Activity.
    Cell Mol Gastroenterol Hepatol Volume: 11 Page(s): 1437 - 1462
    01/01/2021 Authors: Tulasi DY; Castaneda DM; Wager K; Hogan CB; Alcedo KP; Raab JR; Gracz AD
  • Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation.
    Development Volume: 147
    01/03/2020 Authors: Raab JR; Tulasi DY; Wager KE; Morowitz JM; Magness ST; Gracz AD
  • IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model.
    Cell Mol Gastroenterol Hepatol Volume: 7 Page(s): 1 - 17
    01/01/2019 Authors: Zwarycz B; Gracz AD; Rivera KR; Williamson IA; Samsa LA; Starmer J; Daniele MA; Salter-Cid L; Zhao Q; Magness ST
  • Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates.
    Gastroenterology Volume: 155 Page(s): 1508 - 1523.e10
    11/01/2018 Authors: Gracz AD; Samsa LA; Fordham MJ; Trotier DC; Zwarycz B; Lo Y-H; Bao K; Starmer J; Raab JR; Shroyer NF
  • Organoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation.
    Volume: 1799 Page(s): 397 - 417
    01/01/2018 Authors: Zwarycz B; Gracz AD; Magness ST
  • SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine.
    Gastroenterology Volume: 149 Page(s): 1553 - 1563.e10
    11/01/2015 Authors: Roche KC; Gracz AD; Liu XF; Newton V; Akiyama H; Magness ST
  • A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis.
    Nat Cell Biol Volume: 17 Page(s): 340 - 349
    03/01/2015 Authors: Gracz AD; Williamson IA; Roche KC; Johnston MJ; Wang F; Wang Y; Attayek PJ; Balowski J; Liu XF; Laurenza RJ
  • Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways.
    Am J Physiol Gastrointest Liver Physiol Volume: 307 Page(s): G260 - G273
    08/01/2014 Authors: Gracz AD; Magness ST
  • Optimization of 3-D organotypic primary colonic cultures for organ-on-chip applications.
    J Biol Eng Volume: 8 Page(s): 9
    01/01/2014 Authors: Ahmad AA; Wang Y; Gracz AD; Sims CE; Magness ST; Allbritton NL
  • Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells.
    Stem Cells Volume: 31 Page(s): 2024 - 2030
    09/01/2013 Authors: Gracz AD; Fuller MK; Wang F; Li L; Stelzner M; Dunn JCY; Martin MG; Magness ST
  • Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.
    Gastroenterology Volume: 145 Page(s): 383-95.e1-21
    08/01/2013 Authors: Wang F; Scoville D; He XC; Mahe MM; Box A; Perry JM; Smith NR; Lei NY; Davies PS; Fuller MK
  • Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.
    Am J Physiol Gastrointest Liver Physiol Volume: 302 Page(s): G1111 - G1132
    05/15/2012 Authors: Van Landeghem L; Santoro MA; Krebs AE; Mah AT; Dehmer JJ; Gracz AD; Scull BP; McNaughton K; Magness ST; Lund PK
  • Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine.
    Methods Mol Biol Volume: 879 Page(s): 89 - 107
    01/01/2012 Authors: Gracz AD; Puthoff BJ; Magness ST
  • Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture.
    Am J Physiol Gastrointest Liver Physiol Volume: 302 Page(s): G10 - G20
    01/01/2012 Authors: Ramalingam S; Daughtridge GW; Johnston MJ; Gracz AD; Magness ST
  • Sry-box (Sox) transcription factors in gastrointestinal physiology and disease.
    Am J Physiol Gastrointest Liver Physiol Volume: 300 Page(s): G503 - G515
    04/01/2011 Authors: Gracz AD; Magness ST
  • Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells.
    Am J Physiol Gastrointest Liver Physiol Volume: 300 Page(s): G409 - G417
    03/01/2011 Authors: von Furstenberg RJ; Gulati AS; Baxi A; Doherty JM; Stappenbeck TS; Gracz AD; Magness ST; Henning SJ
  • Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro.
    Am J Physiol Gastrointest Liver Physiol Volume: 298 Page(s): G590 - G600
    05/01/2010 Authors: Gracz AD; Ramalingam S; Magness ST
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