Publications

• The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir
  PLoS Pathogens Volume: 21
  01/01/2025 Authors: Huang SW; Briganti L; Annamalai AS; Greenwood J; Shkriabai N; Haney R; Armstrong ML; Wempe MF; Singh SP; Francis AC
• HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.
  Nucleic Acids Res Volume: 52 Page(s): 11060 - 11082
  10/14/2024 Authors: Jang S; Bedwell GJ; Singh SP; Yu HJ; Arnarson B; Singh PK; Radhakrishnan R; Douglas AW; Ingram ZM; Freniere C
• Elasticity of the HIV-1 core facilitates nuclear entry and infection.
  PLoS Pathog Volume: 20 Page(s): e1012537
  09/01/2024 Authors: Deshpande A; Bryer AJ; Andino-Moncada JR; Shi J; Hong J; Torres C; Harel S; Francis AC; Perilla JR; Aiken C
• Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
  Nat Commun Volume: 14 Page(s): 5614
  09/12/2023 Authors: Gres AT; Kirby KA; McFadden WM; Du H; Liu D; Xu C; Bryer AJ; Perilla JR; Shi J; Aiken C
• Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
  Nat Commun Volume: 13 Page(s): 5879
  10/06/2022 Authors: Wei G; Iqbal N; Courouble VV; Francis AC; Singh PK; Hudait A; Annamalai AS; Bester S; Huang S-W; Shkriabai N
• Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.
  PLoS Pathog Volume: 18 Page(s): e1010754
  08/01/2022 Authors: Francis AC; Cereseto A; Singh PK; Shi J; Poeschla E; Engelman AN; Aiken C; Melikyan GB
• Sec24C is an HIV-1 host dependency factor crucial for virus replication.
  Nat Microbiol Volume: 6 Page(s): 435 - 444
  04/01/2021 Authors: Rebensburg SV; Wei G; Larue RC; Lindenberger J; Francis AC; Annamalai AS; Morrison J; Shkriabai N; Huang S-W; KewalRamani V
• Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
  Nat Commun Volume: 11 Page(s): 6165
  11/26/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
• HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages.
  Viruses Volume: 12
  10/30/2020 Authors: Francis AC; Marin M; Prellberg MJ; Palermino-Rowland K; Melikyan GB
• Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
  Science Volume: 370 Page(s): 360 - 364
  10/16/2020 Authors: Bester SM; Wei G; Zhao H; Adu-Ampratwum D; Iqbal N; Courouble VV; Francis AC; Annamalai AS; Singh PK; Shkriabai N
• HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
  Nat Commun Volume: 11 Page(s): 3505
  07/14/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
• Facile autofluorescence suppression enabling tracking of single viruses in live cells.
  J Biol Chem Volume: 294 Page(s): 19111 - 19118
  12/13/2019 Authors: Chen Y-C; Sood C; Francis AC; Melikyan GB; Dickson RM
• A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.
  J Virol Volume: 93
  08/15/2019 Authors: Siddiqui MA; Saito A; Halambage UD; Ferhadian D; Fischer DK; Francis AC; Melikyan GB; Ambrose Z; Aiken C; Yamashita M
• HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
  Elife Volume: 8
  05/23/2019 Authors: Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN
• Live-Cell Imaging of Early Steps of Single HIV-1 Infection.
  Viruses Volume: 10
  05/19/2018 Authors: Francis AC; Melikyan GB
• Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport.
  Cell Host Microbe Volume: 23 Page(s): 536 - 548.e6
  04/11/2018 Authors: Francis AC; Melikyan GB
• Novel Labeling Strategy for Automated Detection of Single Virus Fusion and Assessment of HIV-1 Protease Activity in Single Virions
  Volume: 114 Page(s): 604A - 605A
  02/02/2018 Authors: Sood C; Francis AC; Desai TM; Melikyan G
• Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.
  J Drug Des Res Volume: 5
  01/01/2018 Authors: Xu JP; Francis AC; Meuser ME; Mankowski M; Ptak RG; Rashad AA; Melikyan GB; Cocklin S
• An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions.
  J Biol Chem Volume: 292 Page(s): 20196 - 20207
  12/08/2017 Authors: Sood C; Francis AC; Desai TM; Melikyan GB
• Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.
  PLoS Pathog Volume: 13 Page(s): e1006181
  01/01/2017 Authors: Hammonds JE; Beeman N; Ding L; Takushi S; Francis AC; Wang J-J; Melikyan GB; Spearman P
• Loss of capsid protein at the nuclear membrane is a pre-requisite for translocation of HIV-1 pre-integration complexes into the nucleus.
  Volume: 28
  01/01/2017 Authors: Melikian GB; Francis AC
• Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.
  PLoS Pathog Volume: 12 Page(s): e1005709
  06/01/2016 Authors: Francis AC; Marin M; Shi J; Aiken C; Melikyan GB
• Second generation imaging of nuclear/cytoplasmic HIV-1 complexes.
  AIDS Res Hum Retroviruses Volume: 30 Page(s): 717 - 726
  07/01/2014 Authors: Francis AC; Di Primio C; Quercioli V; Valentini P; Boll A; Girelli G; Demichelis F; Arosio D; Cereseto A
• A second generation HIV-IN-EGFP fluorescent viral system to analyze HIV-1 in the nuclear compartment of infected cells
  Volume: 10 Page(s): S19 - S19
  09/19/2013 Authors: Francis AC; Di Primio C; Quercioli V; Boll A; Arosio D; Cereseto A
• Proteome-wide characterization of the RNA-binding protein RALY-interactome using the in vivo-biotinylation-pulldown-quant (iBioPQ) approach.
  J Proteome Res Volume: 12 Page(s): 2869 - 2884
  06/07/2013 Authors: Tenzer S; Moro A; Kuharev J; Francis AC; Vidalino L; Provenzani A; Macchi P
• Role of Phosphorylation in the Nuclear Biology of HIV-1
  CURRENT MEDICINAL CHEMISTRY Volume: 18 Page(s): 2904 - 2912
  07/01/2011 Authors: Francis AC; Di Primio C; Allouch A; Cereseto A
• Role of phosphorylation in the nuclear biology of HIV-1.
  Curr Med Chem Volume: 18 Page(s): 2904 - 2912
  01/01/2011 Authors: Francis AC; Di Primio C; Allouch A; Cereseto A
• Prevalence and pattern of cross-reacting antibodies to HIV in patients with tuberculosis.
  AIDS Res Hum Retroviruses Volume: 24 Page(s): 941 - 946
  07/01/2008 Authors: Swaminathan S; Hanna LE; Sundaramurthi JC; Leonard A; Angayarkanni B; Francis AC; Lakshmi S; Nayak K