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Profile

Ashwanth Francis

  • Department of Pediatrics
    Adjunct Assistant Professor
  • ashwanth.francis@emory.edu
Head shot of Ashwanth Francis

Research

Publications

  • Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir.
    mBio Volume: 16 Page(s): e0361324
    05/14/2025 Authors: Briganti L; Annamalai AS; Bester SM; Wei G; Andino-Moncada JR; Singh SP; Kleinpeter AB; Tripathi M; Nguyen B; Radhakrishnan R
  • The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.
    PLoS Pathog Volume: 21 Page(s): e1012862
    01/01/2025 Authors: Huang S-W; Briganti L; Annamalai AS; Greenwood J; Shkriabai N; Haney R; Armstrong ML; Wempe MF; Singh SP; Francis AC
  • HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.
    Nucleic Acids Res Volume: 52 Page(s): 11060 - 11082
    10/14/2024 Authors: Jang S; Bedwell GJ; Singh SP; Yu HJ; Arnarson B; Singh PK; Radhakrishnan R; Douglas AW; Ingram ZM; Freniere C
  • Elasticity of the HIV-1 core facilitates nuclear entry and infection.
    PLoS Pathog Volume: 20 Page(s): e1012537
    09/01/2024 Authors: Deshpande A; Bryer AJ; Andino-Moncada JR; Shi J; Hong J; Torres C; Harel S; Francis AC; Perilla JR; Aiken C
  • Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
    Nat Commun Volume: 14 Page(s): 5614
    09/12/2023 Authors: Gres AT; Kirby KA; McFadden WM; Du H; Liu D; Xu C; Bryer AJ; Perilla JR; Shi J; Aiken C
  • Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
    Nat Commun Volume: 13 Page(s): 5879
    10/06/2022 Authors: Wei G; Iqbal N; Courouble VV; Francis AC; Singh PK; Hudait A; Annamalai AS; Bester S; Huang S-W; Shkriabai N
  • Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.
    PLoS Pathog Volume: 18 Page(s): e1010754
    08/01/2022 Authors: Francis AC; Cereseto A; Singh PK; Shi J; Poeschla E; Engelman AN; Aiken C; Melikyan GB
  • Sec24C is an HIV-1 host dependency factor crucial for virus replication.
    Nat Microbiol Volume: 6 Page(s): 435 - 444
    04/01/2021 Authors: Rebensburg SV; Wei G; Larue RC; Lindenberger J; Francis AC; Annamalai AS; Morrison J; Shkriabai N; Huang S-W; KewalRamani V
  • Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
    Nat Commun Volume: 11 Page(s): 6165
    11/26/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
  • HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages.
    Viruses Volume: 12
    10/30/2020 Authors: Francis AC; Marin M; Prellberg MJ; Palermino-Rowland K; Melikyan GB
  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
    Science Volume: 370 Page(s): 360 - 364
    10/16/2020 Authors: Bester SM; Wei G; Zhao H; Adu-Ampratwum D; Iqbal N; Courouble VV; Francis AC; Annamalai AS; Singh PK; Shkriabai N
  • HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
    Nat Commun Volume: 11 Page(s): 3505
    07/14/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
  • Facile autofluorescence suppression enabling tracking of single viruses in live cells.
    J Biol Chem Volume: 294 Page(s): 19111 - 19118
    12/13/2019 Authors: Chen Y-C; Sood C; Francis AC; Melikyan GB; Dickson RM
  • A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.
    J Virol Volume: 93
    08/15/2019 Authors: Siddiqui MA; Saito A; Halambage UD; Ferhadian D; Fischer DK; Francis AC; Melikyan GB; Ambrose Z; Aiken C; Yamashita M
  • HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
    Elife Volume: 8
    05/23/2019 Authors: Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN
  • Live-Cell Imaging of Early Steps of Single HIV-1 Infection.
    Viruses Volume: 10
    05/19/2018 Authors: Francis AC; Melikyan GB
  • Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport.
    Cell Host Microbe Volume: 23 Page(s): 536 - 548.e6
    04/11/2018 Authors: Francis AC; Melikyan GB
  • Novel Labeling Strategy for Automated Detection of Single Virus Fusion and Assessment of HIV-1 Protease Activity in Single Virions
    Volume: 114 Page(s): 604A - 605A
    02/02/2018 Authors: Sood C; Francis AC; Desai TM; Melikyan G
  • Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.
    J Drug Des Res Volume: 5
    01/01/2018 Authors: Xu JP; Francis AC; Meuser ME; Mankowski M; Ptak RG; Rashad AA; Melikyan GB; Cocklin S
  • An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions.
    J Biol Chem Volume: 292 Page(s): 20196 - 20207
    12/08/2017 Authors: Sood C; Francis AC; Desai TM; Melikyan GB
  • Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.
    PLoS Pathog Volume: 13 Page(s): e1006181
    01/01/2017 Authors: Hammonds JE; Beeman N; Ding L; Takushi S; Francis AC; Wang J-J; Melikyan GB; Spearman P
  • Loss of capsid protein at the nuclear membrane is a pre-requisite for translocation of HIV-1 pre-integration complexes into the nucleus.
    Volume: 28
    01/01/2017 Authors: Melikian GB; Francis AC
  • Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.
    PLoS Pathog Volume: 12 Page(s): e1005709
    06/01/2016 Authors: Francis AC; Marin M; Shi J; Aiken C; Melikyan GB
  • Second generation imaging of nuclear/cytoplasmic HIV-1 complexes.
    AIDS Res Hum Retroviruses Volume: 30 Page(s): 717 - 726
    07/01/2014 Authors: Francis AC; Di Primio C; Quercioli V; Valentini P; Boll A; Girelli G; Demichelis F; Arosio D; Cereseto A
  • A second generation HIV-IN-EGFP fluorescent viral system to analyze HIV-1 in the nuclear compartment of infected cells
    Volume: 10 Page(s): S19 - S19
    09/19/2013 Authors: Francis AC; Di Primio C; Quercioli V; Boll A; Arosio D; Cereseto A
  • Proteome-wide characterization of the RNA-binding protein RALY-interactome using the in vivo-biotinylation-pulldown-quant (iBioPQ) approach.
    J Proteome Res Volume: 12 Page(s): 2869 - 2884
    06/07/2013 Authors: Tenzer S; Moro A; Kuharev J; Francis AC; Vidalino L; Provenzani A; Macchi P
  • Role of phosphorylation in the nuclear biology of HIV-1.
    Curr Med Chem Volume: 18 Page(s): 2904 - 2912
    01/01/2011 Authors: Francis AC; Di Primio C; Allouch A; Cereseto A
  • Prevalence and pattern of cross-reacting antibodies to HIV in patients with tuberculosis.
    AIDS Res Hum Retroviruses Volume: 24 Page(s): 941 - 946
    07/01/2008 Authors: Swaminathan S; Hanna LE; Sundaramurthi JC; Leonard A; Angayarkanni B; Francis AC; Lakshmi S; Nayak K
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