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Profile

Anthony Donsante

  • Department of Neurosurgery
    Assistant Professor
  • (404) 727-2337
  • anthony.donsante@emory.edu
Head shot of Anthony Donsante

Academic Appointment

  • Instructor, Neurosurgery, Emory University

Education

Degrees

  • BS Biology from Case Western Reserve University
  • BS Mathematics from Case Western Reserve University
  • PhD Molecular Genetics from Washington University in St. Louis

Research

Publications

  • Intrathecal Vector Delivery in Juvenile Rats via Lumbar Cistern Injection.
    J Vis Exp
    03/29/2024 Authors: Donsante A; Rasmussen SA; Fridovich-Keil JL
  • A novel antibody to treat SOD1-related amyotrophic lateral sclerosis.
    Mol Ther Methods Clin Dev Volume: 29 Page(s): 236 - 237
    06/08/2023 Authors: Boulis NM; Donsante A
  • Current and emerging targeted therapies for spinal muscular atrophy.
    Expert Rev Neurother Volume: 23 Page(s): 1189 - 1199
    01/01/2023 Authors: Lakhina Y; Boulis NM; Donsante A
  • Toward the Use of Chemogenetics to Control Spasticity
    Volume: 32 Page(s): 4 - 4
    01/01/2023 Authors: Boulis NM; Poth K; Zhang M; Donsante A
  • Lentiviral-Induced Spinal Cord Gliomas in Rat Model.
    Int J Mol Sci Volume: 22
    11/30/2021 Authors: Nagarajan PP; Tora MS; Neill SG; Federici T; Texakalidis P; Donsante A; Canoll P; Lei K; Boulis NM
  • Minimally Invasive Injection to the Phrenic Nerve in a Porcine Hemidiaphragmatic Paralysis Model: A Pilot Study.
    Neurosurgery Volume: 87 Page(s): 847 - 853
    09/15/2020 Authors: Texakalidis P; Tora MS; Canute S; Hardcastle N; Poth K; Donsante A; Federici T; Javidfar J; Boulis NM
  • Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits.
    Adv Healthc Mater Volume: 9 Page(s): e2000200
    07/01/2020 Authors: Donsante A; Xue J; Poth KM; Hardcastle NS; Diniz B; O'Connor DM; Xia Y; Boulis NM
  • Lot-to-Lot Variation in Adeno-Associated Virus Serotype 9 (AAV9) Preparations.
    Hum Gene Ther Methods Volume: 30 Page(s): 214 - 225
    12/01/2019 Authors: O'Connor DM; Lutomski C; Jarrold MF; Boulis NM; Donsante A
  • Progress in gene and cell therapies for the neuronal ceroid lipofuscinoses.
    Expert Opin Biol Ther Volume: 18 Page(s): 755 - 764
    07/01/2018 Authors: Donsante A; Boulis NM
  • Lot-to-Lot Variation in Intrathecal Self-Complementary Adeno-Associated Virus Serotype 9 (scAAV9) Transduction
    Volume: 26 Page(s): 188 - 188
    05/01/2018 Authors: Donsante A; O'Connor D; Jarrold M; Lutomski C; Boulis N
  • Intracerebroventricular delivery of self-complementary adeno-associated virus serotype 9 to the adult rat brain.
    Gene Ther Volume: 23 Page(s): 401 - 407
    05/01/2016 Authors: Donsante A; McEachin Z; Riley J; Leung CH; Kanz L; O'Connor DM; Boulis NM
  • Gene, Stem Cell, and Alternative Therapies for SCA 1.
    Front Mol Neurosci Volume: 9 Page(s): 67
    01/01/2016 Authors: Wagner JL; O'Connor DM; Donsante A; Boulis NM
  • Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.
    Methods Mol Biol Volume: 1382 Page(s): 399 - 408
    01/01/2016 Authors: McEachin ZT; Donsante A; Boulis N
  • Dose-Response Relationship for Delivery of Adeno-Associated Virus Serotype 9 To the Lateral Ventricles in Rats
    Volume: 22 Page(s): S26 - S26
    05/01/2014 Authors: Donsante A; McEachin Z; Boulis N
  • Prenatal diagnostic conundrum involving anovel ATP7A duplication.
    Clin Genet Volume: 84 Page(s): 97 - 98
    07/01/2013 Authors: Schoonveld C; Donsante A; del Gaudio D; Waggoner D; Das S; Kaler SG
  • Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia.
    Mol Ther Nucleic Acids Volume: 2 Page(s): e101
    06/25/2013 Authors: Haddad MR; Donsante A; Zerfas P; Kaler SG
  • Fetal Brain-Directed AAV5 and AAV9 Gene Therapy Results in Rapid, Robust, and Persistent Transgene Expression in Mouse Choroid Plexus Epithelia
    Volume: 21 Page(s): S147 - S147
    06/01/2013 Authors: Haddad MR; Choi E-Y; Donsante A; Zerfas PM; Kaler SG
  • Choroid Plexus-Directed Viral Gene Therapy as a Source of alpha-N-Acetyl-Glucosaminidase Enzyme Replacement in Cerebrospinal Fluid for Sanfilippo B Syndrome
    Volume: 21 Page(s): S224 - S225
    06/01/2013 Authors: Dickson PI; Kan S-H; Le SQ; Haddad MR; Choi E-Y; Donsante A; Kaler SG
  • L-threo-dihydroxyphenylserine corrects neurochemical abnormalities in a Menkes disease mouse model.
    Ann Neurol Volume: 73 Page(s): 259 - 265
    02/01/2013 Authors: Donsante A; Sullivan P; Goldstein DS; Brinster LR; Kaler SG
  • Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase.
    Hum Mutat Volume: 33 Page(s): 1207 - 1215
    08/01/2012 Authors: Huppke P; Brendel C; Korenke GC; Marquardt I; Donsante A; Yi L; Hicks JD; Steinbach PJ; Wilson C; Elpeleg O
  • In Utero Brain-Directed AAV5 Gene Therapy Results in Rapid, Robust, and Specific Transduction of Choroid Plexus Epithelia: Implications for Rescue of Prenatal Lethal Mouse Models of Neurometabolic Disease
    Volume: 20 Page(s): S66 - S66
    05/01/2012 Authors: Haddad MR; Zerfas PM; Donsante A; Kaler SG
  • Directed Evolution To Create Choroid Plexus-Permissive AAV Capsid Variants: Toward Novel Clinical Management of Lysosomal Storage Disorders
    Volume: 20 Page(s): S229 - S229
    05/01/2012 Authors: Donsante A; Haddad MR; Kaler SG
  • Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
    Hum Mol Genet Volume: 21 Page(s): 1794 - 1807
    04/15/2012 Authors: Yi L; Donsante A; Kennerson ML; Mercer JFB; Garbern JY; Kaler SG
  • Increased frequency of congenital heart defects in Menkes disease.
    Clin Dysmorphol Volume: 21 Page(s): 59 - 63
    04/01/2012 Authors: Hicks JD; Donsante A; Pierson TM; Gillespie MJ; Chou DE; Kaler SG
  • ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease mouse model.
    Mol Ther Volume: 19 Page(s): 2114 - 2123
    12/01/2011 Authors: Donsante A; Yi L; Zerfas PM; Brinster LR; Sullivan P; Goldstein DS; Prohaska J; Centeno JA; Rushing E; Kaler SG
  • AAV9 gene therapy rescues a murine model of Menkes disease
    Volume: 22 Page(s): A77 - A78
    10/01/2011 Authors: Kaler SG; Donsante A; Haddad M-R
  • Somatic Mosaicism in Menkes Disease Suggests Choroid Plexus-Mediated Copper Transport to the Developing Brain (vol 152A, pg 2529, 2010)
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A Volume: 155A Page(s): 2044 - 2044
    08/01/2011 Authors: Donsante A; Johnson P; Jansen LA; Kaler SG
  • Favorably skewed X-inactivation accounts for neurological sparing in female carriers of Menkes disease.
    Clin Genet Volume: 79 Page(s): 176 - 182
    02/01/2011 Authors: Desai V; Donsante A; Swoboda KJ; Martensen M; Thompson J; Kaler SG
  • Molecular correlates of epilepsy in early diagnosed and treated Menkes disease.
    J Inherit Metab Dis Volume: 33 Page(s): 583 - 589
    10/01/2010 Authors: Kaler SG; Liew CJ; Donsante A; Hicks JD; Sato S; Greenfield JC
  • Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain.
    Am J Med Genet A Volume: 152A Page(s): 2529 - 2534
    10/01/2010 Authors: Donsante A; Johnson P; Jansen LA; Kaler SG
  • Transduction of choroid plexus epithelia is crucial for gene therapy rescue in a murine model of Menkes disease
    Volume: 21 Page(s): 1425 - 1426
    10/01/2010 Authors: Donsante A; Yi L; Zerfas P; Brinster L; Sullivan P; Goldstein D; Prohaska J; Centeno J; Kaler SG
  • TISSUE-SPECIFIC SOMATIC MOSAICISM ASSOCIATED WITH CLASSICAL MENKES DISEASE
    Volume: 99 Page(s): 212 - 212
    03/01/2010 Authors: Donsante A; Johnson P; Holmes CS; Jansen LA; Kaler SG
  • Combined Brain-Directed Recombinant Adeno-Associated Virus Gene Therapy and Copper Rescues a Murine Model of Severe Menkes Disease
    Volume: 17 Page(s): S150 - S150
    05/01/2009 Authors: Donsante A; Tang J; Brinster LR; Holmes CS; Goldstein DS; Centeno JA; Kaler SG
  • Translational read-through of a nonsense mutation in ATP7A impacts treatment outcome in Menkes disease.
    Ann Neurol Volume: 65 Page(s): 108 - 113
    01/01/2009 Authors: Kaler SG; Tang J; Donsante A; Kaneski CR
  • Clinical outcomes in Menkes disease patients with a copper-responsive ATP7A mutation, G727R.
    Mol Genet Metab Volume: 95 Page(s): 174 - 181
    11/01/2008 Authors: Tang J; Donsante A; Desai V; Patronas N; Kaler SG
  • Neonatal diagnosis and treatment of Menkes disease.
    N Engl J Med Volume: 358 Page(s): 605 - 614
    02/07/2008 Authors: Kaler SG; Holmes CS; Goldstein DS; Tang J; Godwin SC; Donsante A; Liew CJ; Sato S; Patronas N
  • Differences in ATP7A gene expression underlie intrafamilial variability in Menkes disease/occipital horn syndrome (vol 44, pg 492, 2007)
    JOURNAL OF MEDICAL GENETICS Volume: 45 Page(s): 64 - 64
    01/01/2008 Authors: Donsante A; Tang J; Godwin SC; Holmes CS; Goldstein DS; Bassuk A; Kaler SG
  • Differences in ATP7A gene expression underlie intrafamilial variability in Menkes disease/occipital horn syndrome.
    J Med Genet Volume: 44 Page(s): 492 - 497
    08/01/2007 Authors: Donsante A; Tang J; Godwin SC; Holmes CS; Goldstein DS; Bassuk A; Kaler SG
  • AAV vector integration sites in mouse hepatocellular carcinoma.
    Science Volume: 317 Page(s): 477
    07/27/2007 Authors: Donsante A; Miller DG; Li Y; Vogler C; Brunt EM; Russell DW; Sands MS
  • Clinical response to persistent, low-level beta-glucuronidase expression in the murine model of mucopolysaccharidosis type VII.
    J Inherit Metab Dis Volume: 30 Page(s): 227 - 238
    04/01/2007 Authors: Donsante A; Levy B; Vogler C; Sands MS
  • Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy.
    Mol Ther Volume: 15 Page(s): 44 - 52
    01/01/2007 Authors: Lin D; Donsante A; Macauley S; Levy B; Vogler C; Sands MS
  • Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
    Gene Ther Volume: 8 Page(s): 1343 - 1346
    09/01/2001 Authors: Donsante A; Vogler C; Muzyczka N; Crawford JM; Barker J; Flotte T; Campbell-Thompson M; Daly T; Sands MS
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