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Profile

Ashish Sharma

  • Department of Pathology and Laboratory Medicine
    Assistant Professor
  • ashish.arunkumar.sharma@emory.edu

Research

Publications

  • Compromised Intestinal Barrier Resilience to Disruption in People with HIV.
    J Infect Dis
    03/06/2025 Authors: Shaikh MW; Singh S; Giron LB; Zhang L; Shankaran S; Engen PA; Villanueva M; Sharma AA; Sekaly R-P; Landay A
  • Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells.
    bioRxiv
    08/03/2024 Authors: Moysi E; Sharma AA; O'Dell S; Georgakis S; Del Rio Estrada PM; Torres-Ruiz F; Navarro MG; Villalobos YAL; Rios SA; Reyes-Teran G
  • DDIT4L regulates mitochondrial and innate immune activities in early life.
    JCI Insight Volume: 9
    02/06/2024 Authors: Michalski C; Cheung C; Oh JH; Ackermann E; Popescu CR; Archambault A-S; Prusinkiewicz MA; Da Silva R; Majdoubi A; Vieta Paramo M
  • Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.
    Tuberculosis (Edinb) Volume: 144 Page(s): 102462
    01/01/2024 Authors: Tomalka J; Sharma A; Smith AGC; Avaliani T; Gujabidze M; Bakuradze T; Sabanadze S; Jones DP; Avaliani Z; Kipiani M
  • Pharmacometabolomics in TB Meningitis - understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.

    12/15/2023 Authors: Collins JM; Kipiani M; Jin Y; Sharma AA; Tomalka JA; Avaliani T; Gujabidze M; Bakuradze T; Sabanadze S; Avaliani Z
  • Regulation of Immune Homeostasis, Inflammation, and HIV Persistence by the Microbiome, Short-Chain Fatty Acids, and Bile Acids.
    Annu Rev Virol Volume: 10 Page(s): 397 - 422
    09/29/2023 Authors: Enriquez AB; Ten Caten F; Ghneim K; Sekaly R-P; Sharma AA
  • Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART.
    Elife Volume: 12
    09/19/2023 Authors: Blanch-Lombarte O; Ouchi D; Jimenez-Moyano E; Carabelli J; Marin MA; Pea R; Pelletier A; Talla A; Sharma A; Dalmau J
  • CD8+ Tcells promote HIV latency by remodeling CD4+ Tcell metabolism to enhance their survival, quiescence, and stemness.
    Immunity Volume: 56 Page(s): 1132 - 1147.e6
    05/09/2023 Authors: Mutascio S; Mota T; Franchitti L; Sharma AA; Willemse A; Bergstresser SN; Wang H; Statzu M; Tharp GK; Weiler J
  • Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
    J Exp Med Volume: 220
    05/01/2023 Authors: Sharma M; Leung D; Momenilandi M; Jones LCW; Pacillo L; James AE; Murrell JR; Delafontaine S; Maimaris J; Vaseghi-Shanjani M
  • Human complete NFAT1 deficiency causes a triad ofjoint contractures, osteochondromas, and B-cellmalignancy.
    Blood Volume: 140 Page(s): 1858 - 1874
    10/27/2022 Authors: Sharma M; Fu MP; Lu HY; Sharma AA; Modi BP; Michalski C; Lin S; Dalmann J; Salman A; Del Bel KL
  • Targeted Marrow Irradiation Intensification of Reduced-Intensity Fludarabine/Busulfan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation.
    Transplant Cell Ther Volume: 28 Page(s): 370.e1 - 370.e10
    07/01/2022 Authors: Ali N; Sharma AA; de Rezende ACP; Otegbeye F; Latif BM; Kerbauy MN; Cooper BW; Sanchez G; Metheny L; Bal SK
  • Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection.
    J Clin Invest Volume: 132
    05/02/2022 Authors: Ferrari B; Da Silva AC; Liu KH; Saidakova EV; Korolevskaya LB; Shmagel KV; Shive C; Pacheco Sanchez G; Retuerto M; Sharma AA
  • Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection.
    JCI Insight Volume: 7
    04/22/2022 Authors: Rahman SA; Billingsley JM; Sharma AA; Styles TM; Govindaraj S; Shanmugasundaram U; Babu H; Riberio SP; Ali SA; Tharp GK
  • IFN- blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.
    JCI Insight Volume: 7
    03/08/2022 Authors: Swainson LA; Sharma AA; Ghneim K; Ribeiro SP; Wilkinson P; Dunham RM; Albright RG; Wong S; Estes JD; Piatak M
  • Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection.
    Transl Res Volume: 241 Page(s): 83 - 95
    03/01/2022 Authors: Latif MB; Shukla S; Del Rio Estrada PM; Ribeiro SP; Sekaly RP; Sharma AA
  • Multiple site place-of-care manufactured anti-CD19 CAR-T cells induce high remission rates in B-cell malignancy patients.
    Nat Commun Volume: 12 Page(s): 7200
    12/10/2021 Authors: Maschan M; Caimi PF; Reese-Koc J; Sanchez GP; Sharma AA; Molostova O; Shelikhova L; Pershin D; Stepanov A; Muzalevskii Y
  • Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency.
    J Allergy Clin Immunol Volume: 148 Page(s): 1559 - 1574.e13
    12/01/2021 Authors: Lu HY; Sharma M; Sharma AA; Lacson A; Szpurko A; Luider J; Dharmani-Khan P; Shameli A; Bell PA; Guilcher GMT
  • Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.
    Leukemia Volume: 35 Page(s): 2799 - 2812
    10/01/2021 Authors: Stetson LC; Balasubramanian D; Ribeiro SP; Stefan T; Gupta K; Xu X; Fourati S; Roe A; Jackson Z; Schauner R
  • The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination.
    Nat Immunol Volume: 22 Page(s): 1294 - 1305
    10/01/2021 Authors: Tomalka JA; Pelletier AN; Fourati S; Latif MB; Sharma A; Furr K; Carlson K; Lifton M; Gonzalez A; Wilkinson P
  • TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.
    PLoS Pathog Volume: 17 Page(s): e1009941
    09/01/2021 Authors: Collins JM; Jones DP; Sharma A; Khadka M; Liu KH; Kempker RR; Prideaux B; Maner-Smith K; Tukvadze N; Shah NS
  • Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2-host interactome.
    Cell Death Dis Volume: 12 Page(s): 788
    08/12/2021 Authors: Messina F; Giombini E; Montaldo C; Sharma AA; Zoccoli A; Sekaly R-P; Locatelli F; Zumla A; Maeurer M; Capobianchi MR
  • CD8+lymphocyte mediated suppression of HIV expression in CD4(+) T cells
    Volume: 51 Page(s): 104 - 104
    08/01/2021 Authors: Franchitti L; Sharma AA; Yoon J; White E; Zhang Z; Wang H; Statzu M; Willemse AE; Bateganya L; Silvestri G
  • Translocated microbiome composition determines immunological outcome in treated HIV infection.
    Cell Volume: 184 Page(s): 3899 - 3914.e16
    07/22/2021 Authors: Nganou-Makamdop K; Talla A; Sharma AA; Darko S; Ransier A; Laboune F; Chipman JG; Beilman GJ; Hoskuldsson T; Fourati S
  • "Go", "No Go," or "Where to Go"; does microbiota dictate T cell exhaustion, programming, and HIV persistence?
    Curr Opin HIV AIDS Volume: 16 Page(s): 215 - 222
    07/01/2021 Authors: Shukla S; Kumari S; Bal SK; Monaco DC; Ribeiro SP; Sekaly R-P; Sharma AA
  • Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype.
    Front Immunol Volume: 12 Page(s): 655027
    01/01/2021 Authors: Razzaghian HR; Sharafian Z; Sharma AA; Boyce GK; Lee K; Da Silva R; Orban PC; Sekaly R-P; Ross CJ; Lavoie PM
  • Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques.
    Cell Volume: 183 Page(s): 185 - 196.e14
    10/01/2020 Authors: Alter G; Yu W-H; Chandrashekar A; Borducchi EN; Ghneim K; Sharma A; Nedellec R; McKenney KR; Linde C; Broge T
  • Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma.
    Front Immunol Volume: 11 Page(s): 1941
    01/01/2020 Authors: Jackson Z; Roe A; Sharma AA; Lopes FBTP; Talla A; Kleinsorge-Block S; Zamborsky K; Schiavone J; Manjappa S; Schauner R
  • Anisocytosis is Associated With Short-Term Mortality in COVID-19 and May Reflect Proinflammatory Signature in Uninfected Ambulatory Adults.
    Pathog Immun Volume: 5 Page(s): 312 - 326
    01/01/2020 Authors: Hornick A; Tashtish N; Osnard M; Shah B; Bradigan A; Albar Z; Tomalka J; Dalton J; Sharma A; Sekaly RP
  • Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells.
    Sci Rep Volume: 9 Page(s): 14916
    10/17/2019 Authors: Ojo EO; Sharma AA; Liu R; Moreton S; Checkley-Luttge M-A; Gupta K; Lee G; Lee DA; Otegbeye F; Sekaly R-P
  • Impaired NLRP3 inflammasome activity during fetal development regulates IL-1 production in human monocytes.
    Eur J Immunol Volume: 45 Page(s): 238 - 249
    01/01/2015 Authors: Sharma AA; Jen R; Kan B; Sharma A; Marchant E; Tang A; Gadawski I; Senger C; Skoll A; Turvey SE
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