Week 5 (April 15)

Completing the Picture: Uniting the Country's COVID-19 Data
Garg, Shikha. “Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020.” MMWR. Morbidity and Mortality Weekly Report 69 (2020). View Publication

COVID-19 and Public Health Interventions in Wuhan, China
Pan, An et al. “Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China.” JAMA, April 10, 2020. View Publication

COVID-19: Transmission to Health Care Personnel
Heinzerling, Amy. “Transmission of COVID-19 to Health Care Personnel During Exposures to a Hospitalized Patient — Solano County, California, February 2020.” MMWR. Morbidity and Mortality Weekly Report 69 (2020). View Publication

COVID-19: Predicting COVID's Return
Kissler, Stephen M., Christine Tedijanto, Edward Goldstein, Yonatan H. Grad, and Marc Lipsitch. “Projecting the Transmission Dynamics of SARS-CoV-2 through the Postpandemic Period.” Science, April 14, 2020. View Publication

Neurological Manifestations of COVID-19
Mao, Ling et al. “Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.” JAMA Neurology, April 10, 2020. View Publication

Recognition and Management of Coagulopathy
Thachil, Jecko et al. “ISTH Interim Guidance on Recognition and Management of Coagulopathy in COVID-19.” Journal of Thrombosis and Haemostasis n/a, no. n/a. Accessed April 15, 2020. View Publication

COVID-19: Predicting deterioration
Ji, Dong et al. “Prediction for Progression Risk in Patients with COVID-19 Pneumonia: The CALL Score.” Clinical Infectious Diseases. Accessed April 15, 2020. View Publication

COVID-19: Some nucleocapsids and RNA walk into a lab...
“Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein | MedRxiv.” Accessed April 15, 2020. View Publication

COVID-19: Virologic Assessment in Body Sites
Wölfel, Roman et al. “Virological Assessment of Hospitalized Patients with COVID-2019.” Nature, April 1, 2020, 1–10. View Publication

Universal Screening for SARS-CoV-2
Sutton, Desmond, Karin Fuchs, Mary D’Alton, and Dena Goffman. “Universal Screening for SARS-CoV-2 in Women Admitted for Delivery.” New England Journal of Medicine 0, no. 0 (April 13, 2020): null. View Publication

COVID-19: Compassionate Use of Remdesivir for Severe Cases
Grein, Jonathan, Norio Ohmagari, Daniel Shin, George Diaz, Erika Asperges, Antonella Castagna, Torsten Feldt, et al. “Compassionate Use of Remdesivir for Patients with Severe Covid-19.” New England Journal of Medicine 0, no. 0 (April 10, 2020): null. View Publication

COVID-19: Hydroxychloroquine Use
“No Evidence of Clinical Efficacy of Hydroxychloroquine in Patients Hospitalized for COVID-19 Infection with Oxygen Requirement: Results of a Study Using Routinely Collected Data to Emulate a Target Trial | MedRxiv.” Accessed April 15, 2020. View Publication Preprint.

COVID-19: Ribonucleoside analog β-D-N4-hydroxycytidine (NHC)
Sheahan, Timothy P. et al. “An Orally Bioavailable Broad-Spectrum Antiviral Inhibits SARS-CoV-2 in Human Airway Epithelial Cell Cultures and Multiple Coronaviruses in Mice.” Science Translational Medicine, April 6, 2020. View Publication

COVID-19: Screening and Severity in Children
Tagarro A, Epalza C, Santos M, et al. Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain [published online ahead of print, 2020 Apr 8]. JAMA Pediatr. 2020;e201346. doi:10.1001/jamapediatrics.2020.1346

COVID-19: Structure of the RNA-Dependent RNA Polymerase
Gao, Yan et al. “Structure of the RNA-Dependent RNA Polymerase from COVID-19 Virus.” Science, April 10, 2020. View Publication

Investigating Animal Transmission of SARS-CoV-2
Shi, Jianzhong, Zhiyuan Wen, Gongxun Zhong, Huanliang Yang, Chong Wang, Baoying Huang, Renqiang Liu, et al. “Susceptibility of Ferrets, Cats, Dogs, and Other Domesticated Animals to SARS–Coronavirus 2.” Science, April 8, 2020. View Publication

Does SARS-CoV-2 infect T-lymphocytes and how?
Wang, Xinling et al. “SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion.” Cellular & Molecular Immunology, April 7, 2020, 1–3. View Publication

COVID-19: How Can We Ration Resources Fairly?
Emanuel, Ezekiel J. et al. “Fair Allocation of Scarce Medical Resources in the Time of Covid-19.” New England Journal of Medicine, March 23, 2020. View Publication

Navigating COVID-19 Ethically and Legally
Gostin, Lawrence O., Eric A. Friedman, and Sarah A. Wetter. “Responding to COVID-19: How to Navigate a Public Health Emergency Legally and Ethically.” Hastings Center Report n/a, no. n/a. Accessed April 15, 2020. View Publication

Mental Health Outcomes among Exposed Health Care Workers
Lai, Jianbo et al. “Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019.” JAMA Network Open 3, no. 3 (March 2, 2020): e203976–e203976. View Publication
Week 4 (April 8)

COVID-19: Estimates of Severity, a Model-Based Analysis
Verity, Robert et al. “Estimates of the Severity of Coronavirus Disease 2019: A Model-Based Analysis.” The Lancet Infectious Diseases 0, no. 0 (March 30, 2020). View Publication

Snapshot of SARS-CoV-2: ICU course and outcomes in Lombardy, Italy
Grasselli, Giacomo et al. “Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.” JAMA, April 6, 2020. View Publication

COVID-19: Presymptomatic Transmission
Wei, Wycliffe E. “Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020.” MMWR. Morbidity and Mortality Weekly Report 69 (2020). View Publication

COVID-19: Contaminated Isolation
Santarpia, Joshua L. et al. “Transmission Potential of SARS-CoV-2 in Viral Shedding Observed at the University of Nebraska Medical Center.” MedRxiv, March 26, 2020, 2020.03.23.20039446. View Publication

Heat & Humidity: Transmission of SARS-CoV-2
Luo, Chao et al. “Possible Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Public Bath Center in Huai’an, Jiangsu Province, China.” JAMA Network Open 3, no. 3 (March 2, 2020): e204583–e204583. View Publication

Clinical and Virological Data from Europe's First COVID-19 Cases
Lescure, Francois-Xavier et al. “Clinical and Virological Data of the First Cases of COVID-19 in Europe: A Case Series.” The Lancet Infectious Diseases 0, no. 0 (March 27, 2020). View Publication

Sample Pooling: Community Monitoring of SARS-CoV-2
Hogan, Catherine A. et al. “Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2.” JAMA, April 6, 2020. View Publication

COVID-19: The Media Coverage This Virus Really Needs
Rodino, Kyle G. et al. “Evaluation of Saline, Phosphate Buffered Saline and Minimum Essential Medium as Potential Alternatives to Viral Transport Media for SARS-CoV-2 Testing.” Journal of Clinical Microbiology, March 30, 2020, JCM.00590-20, jcm;JCM.00590-20v1. View Publication

COVID-19: Investigational Therapeutics: Ivermectin
Caly, Leon et al. “The FDA-Approved Drug Ivermectin Inhibits the Replication of SARS-CoV-2 in Vitro.” Antiviral Research, April 3, 2020, 104787. View Publication

COVID-19: Hydroxychloroquine and azithromycin therapy
Molina, Jean Michel et al. “No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection.” Médecine et Maladies Infectieuses, March 30, 2020. View Publication

COVID-19: Microneedle Array Vaccines
Kim, Eun et al. “Microneedle Array Delivered Recombinant Coronavirus Vaccines: Immunogenicity and Rapid Translational Development.” EBioMedicine, April 2, 2020, 102743. View Publication

RBD: It is a Really Big Deal for Vaccines?
Tai, Wanbo et al. “Characterization of the Receptor-Binding Domain (RBD) of 2019 Novel Coronavirus: Implication for Development of RBD Protein as a Viral Attachment Inhibitor and Vaccine.” Cellular & Molecular Immunology, March 19, 2020. View Publication

COVID-19 in Children
CDC MMWR. “Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020.” MMWR. Morbidity and Mortality Weekly Report 69 (2020). View Publication

COVID-19: Cases in Pediatric Cancer Patients
“Lessons After the Early Management of the COVID-19 Outbreak in a Pediatric Transplant and HematoOncology Center Embedded within a COVID-19 Dedicated Hospital in Lombardia, Italy. Estote Parati. by Adriana Balduzzi et al. Preprint. View Publication

COVID-19: Breastfeeding in COVID-19 (+) mothers
Davanzo, Riccardo et al. “Breastfeeding and Coronavirus Disease-2019. Ad Interim Indications of the Italian Society of Neonatology Endorsed by the Union of European Neonatal & Perinatal Societies.” Maternal & Child Nutrition n/a, no. n/a (n.d.): e13010. View Publication

Over-activation of complement in severe coronavirus infections
Gao, Ting et al. “Highly Pathogenic Coronavirus N Protein Aggravates Lung Injury by MASP-2-Mediated Complement over-Activation.” MedRxiv, April 7, 2020, 2020.03.29.20041962. View Publication

COVID-19: Interferons as potential therapy
Mantlo, Emily K. et al. “Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection.” BioRxiv, April 5, 2020, 2020.04.02.022764. View Publication
Week 3 (April 1)

COVID-19: Potential Drug Targets
“A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.” Gordon et al. Preprint: View Publication

ACEi/ARBs in COVID-19: Beneficial, Bad, or Benign?
“Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19.” Solomon et al. View Publication

COVID-19: Silent Spread
Kimball, Anne. “Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility — King County, Washington, March 2020.” MMWR. Morbidity and Mortality Weekly Report 69 (2020). View Publication

Antibodies in Infants Born to Mothers With COVID-19 Pneumonia
Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. Published online March 26, 2020. View Publication

Neonatal COVID-19 Infection
Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. View Publication

COVID-19: Early Spread of SARS-Cov-2 in the Icelandic Population
Gudbjartsson, Daniel F. et al. “Early Spread of SARS-Cov-2 in the Icelandic Population.” Preprint. Epidemiology, March 30, 2020. View Publication

COVID-19: Serological Assay Development
Fatima Amanat et al, “A Serological Assay to Detect SARS-CoV-2 Seroconversion in Humans | MedRxiv.” Posted March 18, 2020. View Publication

COVID-19: Clinical Course of ICU Patients in Seattle
Bhatraju, Pavan K. et al. “Covid-19 in Critically Ill Patients in the Seattle Region — Case Series.” New England Journal of Medicine 0, no. 0 (March 30, 2020): null. View Publication

COVID-19: Is Troponin a Predictor of Mortailty
Shi, Shaobo et al. “Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.” JAMA Cardiology, March 25, 2020. View Publication

Immunity Gone Wrong: Immune Dysregulation in COVID-19
Mehta, Puja et al. “COVID-19: consider cytokine storm syndromes and immunosuppression.” The Lancet, March 16, 2020. View Publication
Frey, Noelle et al. “Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy.” Biol Blood Marrow Transplantation, December 17, 2018. View Publication

COVID-19: Membrane Fusion Inhibitor Design
Zhu, Yuanmei, Danwei Yu, Hongxia Yan, Huihui Chong, and Yuxian He. “Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity.” BioRxiv, March 28, 2020, 2020.03.26.009233. View Publication

Risk Factors Associated With ARDS and Death
Wu, Chaomin et al. “Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.” JAMA Intern Med. March 13, 2020. View Publication

COVID-19: Association with acute pulmonary embolism?
Danzi, Gian et al. “Acute pulmonary embolism and COVID-19 pneumonia: a random association?” [published online ahead of print, 2020 Mar 30]. Eur Heart J. View Publication

SARS-CoV-2: A Genomic Analysis of Transmission in the US
Fauver, Joseph R. et al. “Coast-to-Coast Spread of SARS-CoV-2 in the United States Revealed by Genomic Epidemiology.” MedRxiv, March 26, 2020. View Publication

SARS-CoV-2 Inhibition by VHH Antibodies
Wrapp, Daniel et al. “Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.” BioRxiv, March 28, 2020, 2020.03.26.010165. (Preprint) View Publication

COVID-19: Epidemiology of COVID-19 in a Long-Term Care Facility in King County, Washington
McMichael, Temet M. et al. “Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington.” New England Journal of Medicine 0, no. 0 (March 27, 2020): null. View Publication

Possible vertical transmission of SARS-CoV-2
Dong L, Tian J, He S, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Published online March 26, 2020. View Publication

How Contaminated is Your Hospital? SARS-CoV-2 on Surfaces
Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers. (Preprint) View Publication

Community Prevalence of COVID-19 Among Patients with Flu-like Symptoms
Spellberg, Brad et al. “Community Prevalence of SARS-CoV-2 Among Patients With Influenza-like Illnesses Presenting to a Los Angeles Medical Center in March 2020.” JAMA, March 31, 2020. View Publication