David Pallas PhD
- Department of Biochemistry
Associate Professor
- (404) 727-5620
- dpallas@emory.edu
- Lab website
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Emory University School of Medicine
Biochemistry
1510 Clifton Rd., Room 4125 RRC
Overview
The primary purpose of the research in my laboratory is to understand the molecular basis of the control of cell proliferation and of mechanisms by which this control is circumvented in neoplastic cell growth. This knowledge will be applied to help identify new targets for small molecule drug therapy for cancer and other diseases in which aberrant cell proliferation is involved.
Academic Appointment
- Associate Professor, Winship Cancer Institute, Emory University School of Medicine
- Associate Professor of Biochemistry, Emory University School of Medicine
Education
Degrees
- PhD from Massachusetts Institute of Technology
- BS from University of Georgia
Research
Focus
- The primary purpose of the research in my laboratory is to understand the molecular basis of the control of cell proliferation and of mechanisms by which this control is circumvented in neoplastic cell growth. This knowledge will be applied to help identify new targets for small molecule drug therapy for cancer and other diseases in which aberrant cell proliferation is involved.
Publications
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Integrin 51 regulates PP2A complex assembly through PDE4D in atherosclerosis.
J Clin Invest Volume: 129 Page(s): 4863 - 4874
08/13/2019 Authors: Yun S; Hu R; Schwaemmle ME; Scherer AN; Zhuang Z; Koleske AJ; Pallas DC; Schwartz MA -
p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.
Mol Cancer Res Volume: 17 Page(s): 186 - 198
01/01/2019 Authors: Wei Y; Maximov V; Morrissy SA; Taylor MD; Pallas DC; Kenney AM -
Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.
Mol Biol Cell Volume: 29 Page(s): 2084 - 2097
08/15/2018 Authors: Qadota H; Matsunaga Y; Bagchi P; Lange KI; Carrier KJ; Pols WV; Swartzbaugh E; Wilson KJ; Srayko M; Pallas DC -
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
J Biol Chem Volume: 293 Page(s): 9636 - 9650
06/22/2018 Authors: Lee JA; Wang Z; Sambo D; Bunting KD; Pallas DC -
Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
J Biol Chem Volume: 291 Page(s): 21008 - 21019
09/30/2016 Authors: Hwang J; Lee JA; Pallas DC -
STRIPAK complexes: structure, biological function, and involvement in human diseases.
Int J Biochem Cell Biol Volume: 47 Page(s): 118 - 148
02/01/2014 Authors: Hwang J; Pallas DC -
Structural basis of PP2A phosphatase activator reveals a unique chaperone function in PP2A activation
Volume: 27
04/01/2013 Authors: Guo F; Stanevich V; Wlodarchak N; Li Y; Pallas DC; Sengupta R; Jiang L; Satyshur KA; Xing Y -
Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner.
Neoplasia Volume: 14 Page(s): 585 - 599
07/01/2012 Authors: Jackson JB; Pallas DC -
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.
BMC Biochem Volume: 12 Page(s): 54
10/10/2011 Authors: Gordon J; Hwang J; Carrier KJ; Jones CA; Kern QL; Moreno CS; Karas RH; Pallas DC -
The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.
J Virol Volume: 83 Page(s): 8340 - 8352
09/01/2009 Authors: Li S; Brignole C; Marcellus R; Thirlwell S; Binda O; McQuoid MJ; Ashby D; Chan H; Zhang Z; Miron M-J