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Profile

David Pallas PhD

  • Department of Biochemistry
    Associate Professor
  • (404) 727-5620
  • dpallas@emory.edu
  • Lab website
  • Emory University School of Medicine
    Biochemistry
    1510 Clifton Rd., Room 4125 RRC
Head shot of David Pallas

Overview

The primary purpose of the research in my laboratory is to understand the molecular basis of the control of cell proliferation and of mechanisms by which this control is circumvented in neoplastic cell growth. This knowledge will be applied to help identify new targets for small molecule drug therapy for cancer and other diseases in which aberrant cell proliferation is involved.

Academic Appointment

  • Associate Professor, Winship Cancer Institute, Emory University School of Medicine
  • Associate Professor of Biochemistry, Emory University School of Medicine

Education

Degrees

  • PhD from Massachusetts Institute of Technology
  • BS from University of Georgia

Research

Focus

  • The primary purpose of the research in my laboratory is to understand the molecular basis of the control of cell proliferation and of mechanisms by which this control is circumvented in neoplastic cell growth. This knowledge will be applied to help identify new targets for small molecule drug therapy for cancer and other diseases in which aberrant cell proliferation is involved.

Publications

  • Integrin 51 regulates PP2A complex assembly through PDE4D in atherosclerosis.
    J Clin Invest Volume: 129 Page(s): 4863 - 4874
    08/13/2019 Authors: Yun S; Hu R; Schwaemmle ME; Scherer AN; Zhuang Z; Koleske AJ; Pallas DC; Schwartz MA
  • p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.
    Mol Cancer Res Volume: 17 Page(s): 186 - 198
    01/01/2019 Authors: Wei Y; Maximov V; Morrissy SA; Taylor MD; Pallas DC; Kenney AM
  • Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.
    Mol Biol Cell Volume: 29 Page(s): 2084 - 2097
    08/15/2018 Authors: Qadota H; Matsunaga Y; Bagchi P; Lange KI; Carrier KJ; Pols WV; Swartzbaugh E; Wilson KJ; Srayko M; Pallas DC
  • Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
    J Biol Chem Volume: 293 Page(s): 9636 - 9650
    06/22/2018 Authors: Lee JA; Wang Z; Sambo D; Bunting KD; Pallas DC
  • Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
    J Biol Chem Volume: 291 Page(s): 21008 - 21019
    09/30/2016 Authors: Hwang J; Lee JA; Pallas DC
  • STRIPAK complexes: structure, biological function, and involvement in human diseases.
    Int J Biochem Cell Biol Volume: 47 Page(s): 118 - 148
    02/01/2014 Authors: Hwang J; Pallas DC
  • Structural basis of PP2A phosphatase activator reveals a unique chaperone function in PP2A activation
    Volume: 27
    04/01/2013 Authors: Guo F; Stanevich V; Wlodarchak N; Li Y; Pallas DC; Sengupta R; Jiang L; Satyshur KA; Xing Y
  • Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner.
    Neoplasia Volume: 14 Page(s): 585 - 599
    07/01/2012 Authors: Jackson JB; Pallas DC
  • Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.
    BMC Biochem Volume: 12 Page(s): 54
    10/10/2011 Authors: Gordon J; Hwang J; Carrier KJ; Jones CA; Kern QL; Moreno CS; Karas RH; Pallas DC
  • The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.
    J Virol Volume: 83 Page(s): 8340 - 8352
    09/01/2009 Authors: Li S; Brignole C; Marcellus R; Thirlwell S; Binda O; McQuoid MJ; Ashby D; Chan H; Zhang Z; Miron M-J
  • Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.
    J Virol Volume: 82 Page(s): 3612 - 3623
    04/01/2008 Authors: Li Y; Wei H; Hsieh T-C; Pallas DC
  • FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.
    J Neurosci Volume: 27 Page(s): 14349 - 14357
    12/26/2007 Authors: Narayanan U; Nalavadi V; Nakamoto M; Pallas DC; Ceman S; Bassell GJ; Warren ST
  • Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells.
    J Biol Chem Volume: 282 Page(s): 30974 - 30984
    10/19/2007 Authors: Lee JA; Pallas DC
  • Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.
    J Neurochem Volume: 101 Page(s): 959 - 971
    05/01/2007 Authors: Nunbhakdi-Craig V; Schuechner S; Sontag J-M; Montgomery L; Pallas DC; Juno C; Mudrak I; Ogris E; Sontag E
  • Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation.
    Drug Chem Toxicol Volume: 30 Page(s): 197 - 216
    01/01/2007 Authors: Morales PR; Dillehay DL; Moody SJ; Pallas DC; Pruett S; Allgood JC; Symolon H; Merrill AH
  • An in vivo assay to quantify stable protein phosphatase 2A (PP2A) heterotrimeric species.
    Methods Mol Biol Volume: 365 Page(s): 71 - 83
    01/01/2007 Authors: Gentry MS; Hallberg RL; Pallas DC
  • Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.
    Org Lett Volume: 8 Page(s): 649 - 652
    02/16/2006 Authors: Dougherty AM; McDonald FE; Liotta DC; Moody SJ; Pallas DC; Pack CD; Merrill AH
  • A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers.
    Eukaryot Cell Volume: 4 Page(s): 1029 - 1040
    06/01/2005 Authors: Gentry MS; Li Y; Wei H; Syed FF; Patel SH; Hallberg RL; Pallas DC
  • Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.
    Proc Natl Acad Sci U S A Volume: 101 Page(s): 17126 - 17131
    12/07/2004 Authors: Lu Q; Pallas DC; Surks HK; Baur WE; Mendelsohn ME; Karas RH
  • Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown.
    Cancer Res Volume: 64 Page(s): 6978 - 6988
    10/01/2004 Authors: Moreno CS; Ramachandran S; Ashby DG; Laycock N; Plattner CA; Chen W; Hahn WC; Pallas DC
  • Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
    Oncogene Volume: 23 Page(s): 5266 - 5274
    07/08/2004 Authors: Iida S-I; Hirota T; Morisaki T; Marumoto T; Hara T; Kuninaka S; Honda S; Kosai K-I; Kawasuji M; Pallas DC
  • Identification of specific PP2A complexes involved in human cell transformation.
    Cancer Cell Volume: 5 Page(s): 127 - 136
    02/01/2004 Authors: Chen W; Possemato R; Campbell KT; Plattner CA; Pallas DC; Hahn WC
  • Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.
    J Biol Chem Volume: 278 Page(s): 40829 - 40836
    10/17/2003 Authors: Shern JF; Sharer JD; Pallas DC; Bartolini F; Cowan NJ; Reed MS; Pohl J; Kahn RA
  • Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A.
    J Biol Chem Volume: 278 Page(s): 4639 - 4645
    02/14/2003 Authors: Lu Q; Surks HK; Ebling H; Baur WE; Brown D; Pallas DC; Karas RH
  • Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.
    J Virol Volume: 76 Page(s): 9194 - 9206
    09/01/2002 Authors: Harada JN; Shevchenko A; Shevchenko A; Pallas DC; Berk AJ
  • Adenovirus E4orf4 specifically kills cancer lines via an interaction with PP2A.
    CLINICAL CANCER RESEARCH Volume: 7 Page(s): 3715S - 3715S
    11/01/2001 Authors: Marcellus RC; Chan HL; Paquette D; Zhang Z; Szymborski A; Miron M; Lavoie JN; Pallas DC; Shore GC; Branton PE
  • A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes.
    J Biol Chem Volume: 276 Page(s): 24253 - 24260
    06/29/2001 Authors: Moreno CS; Lane WS; Pallas DC
  • Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p.
    J Biol Chem Volume: 276 Page(s): 1570 - 1577
    01/12/2001 Authors: Wei H; Ashby DG; Moreno CS; Ogris E; Yeong FM; Corbett AH; Pallas DC
  • Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen.
    Mol Biol Cell Volume: 12 Page(s): 185 - 199
    01/01/2001 Authors: Yu XX; Du X; Moreno CS; Green RE; Ogris E; Feng Q; Chou L; McQuoid MJ; Pallas DC
  • WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A.
    J Biol Chem Volume: 275 Page(s): 5257 - 5263
    02/25/2000 Authors: Moreno CS; Park S; Nelson K; Ashby D; Hubalek F; Lane WS; Pallas DC
  • Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).
    J Virol Volume: 73 Page(s): 7390 - 7398
    09/01/1999 Authors: Ogris E; Mudrak I; Mak E; Gibson D; Pallas DC
  • A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.
    J Biol Chem Volume: 274 Page(s): 14382 - 14391
    05/14/1999 Authors: Ogris E; Du X; Nelson KC; Mak EK; Yu XX; Lane WS; Pallas DC
  • Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins.
    J Virol Volume: 72 Page(s): 558 - 563
    01/01/1998 Authors: Culler X; Rose P; Thathamangalam U; Chatterjee A; Mullane KP; Pallas DC; Benjamin TL; Roberts TM; Schaffhausen BS
  • Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen.
    Oncogene Volume: 15 Page(s): 911 - 917
    08/18/1997 Authors: Ogris E; Gibson DM; Pallas DC
  • Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
    J Virol Volume: 69 Page(s): 3721 - 3728
    06/01/1995 Authors: Campbell KS; Auger KR; Hemmings BA; Roberts TM; Pallas DC
  • POLYOMA T ANTIGENS - OLD ONCOGENES - NEW TRICKS
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 3 - 3
    01/05/1995 Authors: ROBERTS TM; CAMPBELL K; WEN S; KAI X; AUGER K; JING W; AGARWAL S; JUN T; NARSIMHAN R; HASER W
  • Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
    Science Volume: 266 Page(s): 126 - 129
    10/07/1994 Authors: Fu H; Xia K; Pallas DC; Cui C; Conroy K; Narsimhan RP; Mamon H; Collier RJ; Roberts TM
  • One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs.
    Mol Cell Biol Volume: 14 Page(s): 5076 - 5087
    08/01/1994 Authors: Shirra MK; Zhu Q; Huang HC; Pallas D; Hansen U
  • Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
    Science Volume: 265 Page(s): 535 - 537
    07/22/1994 Authors: Pallas DC; Fu H; Haehnel LC; Weller W; Collier RJ; Roberts TM
  • Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.
    Proc Natl Acad Sci U S A Volume: 91 Page(s): 6344 - 6348
    07/05/1994 Authors: Campbell KS; Ogris E; Burke B; Su W; Auger KR; Druker BJ; Schaffhausen BS; Roberts TM; Pallas DC
  • A NOVEL DIMERIZATION REGION IS DELETED IN THE PRODUCT ENCODED BY AN ALTERNATIVELY SPLICED MESSENGER-RNA FOR THE CELL-GROWTH REGULATED TRANSCRIPTION FACTOR LSF
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 37 - 37
    02/13/1994 Authors: SHIRRA M; ZHU Q; VOLKER J; HUANG HC; PALLAS D; HANSEN U
  • The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens.
    J Virol Volume: 66 Page(s): 886 - 893
    02/01/1992 Authors: Pallas DC; Weller W; Jaspers S; Miller TB; Lane WS; Roberts TM
  • CELLULAR PROTEINS THAT INTERACT SPECIFICALLY WITH THE RETINOBLASTOMA GENE-PRODUCT
    CLINICAL RESEARCH Volume: 39 Page(s): A339 - A339
    04/01/1991 Authors: KAELIN WG; PALLAS DC; DECAPRIO JA; KAYE FJ; LIVINGSTON DM
  • Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.
    Cell Volume: 64 Page(s): 521 - 532
    02/08/1991 Authors: Kaelin WG; Pallas DC; DeCaprio JA; Kaye FJ; Livingston DM
  • CELLULAR PROTEINS THAT CAN INTERACT SPECIFICALLY WITH THE RETINOBLASTOMA SUSCEPTIBILITY GENE-PRODUCT
    Page(s): 423 - 431
    01/01/1991 Authors: KAELIN WG; PALLAS DC; DECAPRIO JA; KAYE FJ; LIVINGSTON DM
  • Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.
    Cell Volume: 60 Page(s): 167 - 176
    01/12/1990 Authors: Pallas DC; Shahrik LK; Martin BL; Jaspers S; Miller TB; Brautigan DL; Roberts TM
  • The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins.
    J Virol Volume: 63 Page(s): 4533 - 4539
    11/01/1989 Authors: Pallas DC; Morgan W; Roberts TM
  • Mechanisms of transformation by polyoma virus middle T antigen.
    Biochim Biophys Acta Volume: 948 Page(s): 345 - 364
    02/01/1989 Authors: Kaplan DR; Pallas DC; Morgan W; Schaffhausen B; Roberts TM
  • Cellular proteins that associate with the middle and small T antigens of polyomavirus.
    J Virol Volume: 62 Page(s): 3934 - 3940
    11/01/1988 Authors: Pallas DC; Cherington V; Morgan W; DeAnda J; Kaplan D; Schaffhausen B; Roberts TM
  • Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.
    J Virol Volume: 62 Page(s): 3407 - 3414
    09/01/1988 Authors: Morgan WC; Kaplan DR; Pallas DC; Roberts TM
  • Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens.
    Int J Cancer Volume: 42 Page(s): 123 - 128
    07/15/1988 Authors: Ramqvist T; Pallas DO; DeAnda J; Ahrlund-Richter L; Reinholdsson G; Roberts TM; Schaffhausen BS; Dalianis T
  • Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
    Cell Volume: 50 Page(s): 1021 - 1029
    09/25/1987 Authors: Kaplan DR; Whitman M; Schaffhausen B; Pallas DC; White M; Cantley L; Roberts TM
  • Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.
    J Virol Volume: 60 Page(s): 1075 - 1084
    12/01/1986 Authors: Pallas DC; Schley C; Mahoney M; Harlow E; Schaffhausen BS; Roberts TM
  • Phosphatidylinositol metabolism and polyoma-mediated transformation.
    Proc Natl Acad Sci U S A Volume: 83 Page(s): 3624 - 3628
    06/01/1986 Authors: Kaplan DR; Whitman M; Schaffhausen B; Raptis L; Garcea RL; Pallas D; Roberts TM; Cantley L
  • Cytoplasmic microtubule-associated proteins: phosphorylation at novel sites is correlated with their incorporation into assembled microtubules.
    Cell Volume: 30 Page(s): 407 - 414
    09/01/1982 Authors: Pallas D; Solomon F
  • CYTOPLASMIC MICROTUBULE ASSOCIATED PROTEINS - PHOSPHORYLATION AT SPECIFIC SITES CORRELATES WITH CYTOPLASMIC LOCALIZATION
    JOURNAL OF CELL BIOLOGY Volume: 95 Page(s): A343 - A343
    01/01/1982 Authors: PALLAS D; SOLOMON F
  • Molecular analysis of cytoplasmic microtubules in situ: identification of both widespread and specific proteins.
    Cell Volume: 24 Page(s): 203 - 211
    04/01/1981 Authors: Duerr A; Pallas D; Solomon F
  • MOLECULAR ANALYSIS OF CYTOPLASMIC MICROTUBULES
    JOURNAL OF CELL BIOLOGY Volume: 87 Page(s): A247 - A247
    01/01/1980 Authors: DUERR A; PALLAS D; SOLOMON F
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