Xiaonan Wang MD, MS

Department of Medicine
Consultant (Faculty)

(404) 727-1798
xwang03@emory.edu

Overview

Dr. Xiaonan Wang received her MS in biochemistry from Peking Union Medical College, China and her MD from China Medical University. After receiving her MD, she accepted a position as an attending physician at the PUMC Hospital in China. In 1997, Dr. Wang joined the Division of Renal Medicine at Emory University as an instructor, and in May of 2001, she was named an assistant professor of medicine.

The objective of Dr. Wang's research is to identify molecular and biochemical mechanisms that lead to protein malnutrition in catabolic diseases related to insulin resistance, such as chronic renal disease and diabetes. She uses transgenic mice and cell culture systems to test her hypotheses. Currently, she is exploring the use of gene therapy (using lentiviruses to deliver target genes) to treat muscle protein loss in insulin-deficient diabetic animals.

Academic Appointment

Assistant Professor, Department of Medicine

Education

Degrees

MS from Peking Union Medical College
MD from China Medical University

Research

Focus

Muscle physiology and pathology in catabolic disease (CKD and diabetes), aging and exercise

Publications

Protein-energy wasting in chronic kidney disease: mechanisms responsible for loss of muscle mass and function.
Kidney Res Clin Pract
02/21/2025 Authors: Price SR; Wang XH
The gut microbiome, chronic kidney disease, and sarcopenia.
Cell Commun Signal Volume: 22 Page(s): 558
11/21/2024 Authors: Zheng G; Cao J; Wang XH; He W; Wang B
Endurance Exercise-Induced Fgf21 Promotes Skeletal Muscle Fiber Conversion through TGF-1 and p38 MAPK Signaling Pathway.
Int J Mol Sci Volume: 24
07/13/2023 Authors: Luo X; Zhang H; Cao X; Yang D; Yan Y; Lu J; Wang X; Wang H
Organ Crosstalk Contributes to Muscle Wasting in Chronic Kidney Disease.
Semin Nephrol Volume: 43 Page(s): 151409
03/01/2023 Authors: Wang XH; Price SR
The impact of senescence on muscle wasting in chronic kidney disease.
J Cachexia Sarcopenia Muscle Volume: 14 Page(s): 126 - 141
02/01/2023 Authors: Huang Y; Wang B; Hassounah F; Price SR; Klein J; Mohamed TMA; Wang Y; Park J; Cai H; Zhang X
Pathophysiological mechanisms leading to muscle loss in chronic kidney disease.
Nat Rev Nephrol Volume: 18 Page(s): 138 - 152
03/01/2022 Authors: Wang XH; Mitch WE; Price SR
Downregulation of let-7 by Electrical Acupuncture Increases Protein Synthesis in Mice.
Front Physiol Volume: 12 Page(s): 697139
01/01/2021 Authors: Huang Y; Yu M; Kuma A; Klein JD; Wang Y; Hassounah F; Cai H; Wang XH
MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells.
J Biol Chem Volume: 296 Page(s): 100483
01/01/2021 Authors: Han Y; Zhang J; Huang S; Cheng N; Zhang C; Li Y; Wang X; Liu J; You B; Du J
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice.
J Biol Chem Volume: 295 Page(s): 10212 - 10223
07/24/2020 Authors: Cheng N; Liu C; Li Y; Gao S; Han Y-C; Wang X; Du J; Zhang C
14-3-3, a novel regulator of the large-conductance Ca2+-activated K+ channel.
Am J Physiol Renal Physiol Volume: 319 Page(s): F52 - F62
07/01/2020 Authors: Chen S; Feng X; Chen X; Zhuang Z; Xiao J; Fu H; Klein JD; Wang XH; Hoover RS; Eaton DC
Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease.
FASEB J Volume: 34 Page(s): 8296 - 8309
06/01/2020 Authors: Kuma A; Wang XH; Klein JD; Tan L; Naqvi N; Rianto F; Huang Y; Yu M; Sands JM
UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction.
Am J Physiol Renal Physiol Volume: 318 Page(s): F1160 - F1166
05/01/2020 Authors: Rianto F; Kuma A; Ellis CL; Hassounah F; Rodriguez EL; Wang XH; Sands JM; Klein JD
Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice.
Hum Gene Ther Volume: 31 Page(s): 367 - 375
03/01/2020 Authors: Wang B; Wang J; He W; Zhao Y; Zhang A; Liu Y; Hassounah F; Ma F; Klein JD; Wang XH
Macrophage-Derived Exosomal Mir-155Regulating Cardiomyocyte Pyroptosis and Hypertrophy in UremicCardiomyopathy.
JACC Basic Transl Sci Volume: 5 Page(s): 148 - 166
02/01/2020 Authors: Wang B; Wang Z-M; Ji J-L; Gan W; Zhang A; Shi H-J; Wang H; Lv L; Li Z; Tang T
Stimulatory Role of SPAK Signaling in the Regulation of Large Conductance Ca2+-Activated Potassium (BK) Channel Protein Expression in Kidney.
Front Physiol Volume: 11 Page(s): 638
01/01/2020 Authors: Bi Y; Li C; Zhang Y; Wang Y; Chen S; Yue Q; Hoover RS; Wang XH; Delpire E; Eaton DC
Diaphragmatic dysfunction associates with dyspnoea, fatigue, and hiccup in haemodialysis patients: a cross-sectional study.
Sci Rep Volume: 9 Page(s): 19382
12/18/2019 Authors: Wang B; Yin Q; Wang Y-Y; Tu Y; Han Y; Gao M; Pan M; Yang Y; Xue Y; Zhang L
Exogenous miR-26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease.
FASEB J Volume: 33 Page(s): 13590 - 13601
12/01/2019 Authors: Zhang A; Wang H; Wang B; Yuan Y; Klein JD; Wang XH
Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration.
J Biol Chem Volume: 294 Page(s): 15672 - 15685
10/25/2019 Authors: Zhang J; Qu C; Li T; Cui W; Wang X; Du J
Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice.
Mol Ther Volume: 27 Page(s): 571 - 583
03/06/2019 Authors: Wang H; Wang B; Zhang A; Hassounah F; Seow Y; Wood M; Ma F; Klein JD; Price SR; Wang XH
MICE LACKING INNER MEDULLARY UREA TRANSPORTERS HAVE REDUCED RENAL FIBROSIS FOLLOWING UNILATERAL URETERAL OBSTRUCTION
Volume: 67 Page(s): 616 - 616
02/01/2019 Authors: Rianto F; Ellis CL; Wang XH; Klein JD; Sands JM
UPREGULATION OF A UREA TRANSPORTER IN UREMIC HEART IS LINKED TO CARDIAC FIBROSIS
Volume: 67 Page(s): 617 - 618
02/01/2019 Authors: Kuma A; Wang XH; Klein JD; Sands JM
miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease.
Theranostics Volume: 9 Page(s): 1864 - 1877
01/01/2019 Authors: Wang B; Zhang A; Wang H; Klein JD; Tan L; Wang Z-M; Du J; Naqvi N; Liu B-C; Wang XH
Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181.
Am J Physiol Renal Physiol Volume: 315 Page(s): F1542 - F1549
12/01/2018 Authors: Klein JD; Wang XH
Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181.
Am J Physiol Renal Physiol Volume: 315 Page(s): F1542 - F1549
12/01/2018 Authors: Klein JD; Wang XH
INFLAMMATORY CHANGES IN THE BONE MARROW MICROENVIRONMENT DRIVE BOTH NICHE AND BLOOD SYSTEM REMODELING DURING AGING
Volume: 64 Page(s): S43 - S44
08/01/2018 Authors: Verovskaya E; Calero-Nieto F; Reynaud D; Zhang SY; Herault A; Bakker S; Pietras E; Svendsen AF; Wang X; Kinston S
miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk.
J Cachexia Sarcopenia Muscle Volume: 9 Page(s): 755 - 770
08/01/2018 Authors: Zhang A; Li M; Wang B; Klein JD; Price SR; Wang XH
The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.
J Am Soc Nephrol Volume: 29 Page(s): 1706 - 1719
06/01/2018 Authors: Nanami M; Pham TD; Kim YH; Yang B; Sutliff RL; Staub O; Klein JD; Lopez-Cayuqueo KI; Chambrey R; Park AY
MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy.
J Am Soc Nephrol Volume: 28 Page(s): 2631 - 2640
09/01/2017 Authors: Wang B; Zhang C; Zhang A; Cai H; Price SR; Wang XH
Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle.
Am J Physiol Renal Physiol Volume: 312 Page(s): F1128 - F1140
06/01/2017 Authors: Su Z; Klein JD; Du J; Franch HA; Zhang L; Hassounah F; Hudson MB; Wang XH
Muscle-kidney crosstalk through microRNA-29 in chronic kidney disease mouse
Volume: 31
04/01/2017 Authors: Wang XH; Escobar EM; Zhang A; Klein JD
The Impact of MicroRNA 23/27 on Muscle Atrophy in Diabetic Mice
Volume: 31
04/01/2017 Authors: Escobar EM; Wang X; Hassounah F
Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development.
Curr Mol Med Volume: 17 Page(s): 627 - 636
01/01/2017 Authors: Chen F; Yuan W; Mo X; Zhuang J; Wang Y; Chen J; Jiang Z; Zhu X; Zeng Q; Wan Y
Urea Transporter B and MicroRNA-200c Differ in Kidney Outer Versus Inner Medulla Following Dehydration.
Am J Med Sci Volume: 352 Page(s): 296 - 301
09/01/2016 Authors: Wang J; Wang XH; Wang H; Chen L; Klein JD; Sands JM
Low-Frequency Electrical Stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy by increasing muscle regeneration
Volume: 30
04/01/2016 Authors: Wang XH; Klein JD; Wang H
NEDD4-2 reduces electroneutral Cl-/HCO3- exchange in mouse cortical collecting duct
Volume: 30
04/01/2016 Authors: Truyen DP; Nanami M; Staub O; Sutliff RL; Klein JD; Eladari D; Chambrey R; Wang X; Verlander JW; Wall SM
Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy.
J Appl Physiol (1985) Volume: 120 Page(s): 426 - 436
02/15/2016 Authors: Su Z; Hu L; Cheng J; Klein JD; Hassounah F; Cai H; Li M; Wang H; Wang XH
Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.
Am J Physiol Renal Physiol Volume: 308 Page(s): F1119 - F1127
05/15/2015 Authors: Feng X; Zhang Y; Shao N; Wang Y; Zhuang Z; Wu P; Lee MJ; Liu Y; Wang X; Zhuang J
Acupuncture plus Low-Frequency Electrical Stimulation (Acu/LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration
Volume: 29
04/01/2015 Authors: Robinson A; Klein J; Wang X
Autophagosome-proteolysis contribute to CKD-induced muscle atrophy
Volume: 29
04/01/2015 Authors: Li M; Mitch W; Wang X
Low-frequency electrical stimulation attenuates muscle atrophy in CKD--a potential treatment strategy.
J Am Soc Nephrol Volume: 26 Page(s): 626 - 635
03/01/2015 Authors: Hu L; Klein JD; Hassounah F; Cai H; Zhang C; Xu P; Wang XH
Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration.
PLoS One Volume: 10 Page(s): e0134511
01/01/2015 Authors: Su Z; Robinson A; Hu L; Klein JD; Hassounah F; Li M; Wang H; Cai H; Wang XH
CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration.
J Immunol Volume: 193 Page(s): 5149 - 5160
11/15/2014 Authors: Zhang J; Xiao Z; Qu C; Cui W; Wang X; Du J
Mechanisms of muscle wasting in chronic kidney disease.
Nat Rev Nephrol Volume: 10 Page(s): 504 - 516
09/01/2014 Authors: Wang XH; Mitch WE
increase in microRNA-23 prevents muscle wasting in mice with chronic kidney disease in resistance exercise
Volume: 28
04/01/2014 Authors: Wang X
MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.
Aging (Albany NY) Volume: 6 Page(s): 160 - 175
03/01/2014 Authors: Hu Z; Klein JD; Mitch WE; Zhang L; Martinez I; Wang XH
Aging increases CCN1 expression leading to muscle senescence.
Am J Physiol Cell Physiol Volume: 306 Page(s): C28 - C36
01/01/2014 Authors: Du J; Klein JD; Hassounah F; Zhang J; Zhang C; Wang XH
Role of local versus systemic vitamin D receptors in vascular calcification.
Arterioscler Thromb Vasc Biol Volume: 34 Page(s): 146 - 151
01/01/2014 Authors: Lomashvili KA; Wang X; O'Neill WC
Muscle wasting from kidney failure-a model for catabolic conditions.
Int J Biochem Cell Biol Volume: 45 Page(s): 2230 - 2238
10/01/2013 Authors: Wang XH; Mitch WE
Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis.
Am J Physiol Endocrinol Metab Volume: 305 Page(s): E367 - E375
08/01/2013 Authors: Dong Y; Lakhia R; Thomas SS; Dong Y; Wang XH; Silva KAS; Zhang L
MicroRNA in myogenesis and muscle atrophy.
Curr Opin Clin Nutr Metab Care Volume: 16 Page(s): 258 - 266
05/01/2013 Authors: Wang XH
Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration.
J Biol Chem Volume: 288 Page(s): 1489 - 1499
01/18/2013 Authors: Zhang C; Li Y; Wu Y; Wang L; Wang X; Du J
Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
Am J Physiol Renal Physiol Volume: 303 Page(s): F812 - F820
09/15/2012 Authors: Thumova M; Pech V; Froehlich O; Agazatian D; Wang X; Verlander JW; Kim YH; Wall SM
Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486.
Kidney Int Volume: 82 Page(s): 401 - 411
08/01/2012 Authors: Xu J; Li R; Workeneh B; Dong Y; Wang X; Hu Z
Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs. non-pair-fed rats.
Am J Physiol Renal Physiol Volume: 302 Page(s): F1545 - F1553
06/15/2012 Authors: Bou Matar RN; Malik B; Wang XH; Martin CF; Eaton DC; Sands JM; Klein JD
Decreased miR-29 suppresses myogenesis in CKD.
J Am Soc Nephrol Volume: 22 Page(s): 2068 - 2076
11/01/2011 Authors: Wang XH; Hu Z; Klein JD; Zhang L; Fang F; Mitch WE
Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.
J Biol Chem Volume: 286 Page(s): 28715 - 28722
08/19/2011 Authors: Lomashvili KA; Wang X; Wallin R; O'Neill WC
Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.
Am J Physiol Heart Circ Physiol Volume: 301 Page(s): H61 - H68
07/01/2011 Authors: Villa-Bellosta R; Wang X; Milln JL; Dubyak GR; O'Neill WC
Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease.
FASEB J Volume: 25 Page(s): 1653 - 1663
05/01/2011 Authors: Zhang L; Rajan V; Lin E; Hu Z; Han HQ; Zhou X; Song Y; Min H; Wang X; Du J
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity.
J Biol Chem Volume: 285 Page(s): 21249 - 21257
07/09/2010 Authors: Wang XH; Zhang L; Mitch WE; LeDoux JM; Hu J; Du J
XIAP reduces muscle proteolysis induced by CKD.
J Am Soc Nephrol Volume: 21 Page(s): 1174 - 1183
07/01/2010 Authors: Hu J; Du J; Zhang L; Price SR; Klein JD; Wang XH
PTEN inhibition improves muscle regeneration in mice fed a high-fat diet.
Diabetes Volume: 59 Page(s): 1312 - 1320
06/01/2010 Authors: Hu Z; Wang H; Lee IH; Modi S; Wang X; Du J; Mitch WE
Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy.
J Am Soc Nephrol Volume: 21 Page(s): 419 - 427
03/01/2010 Authors: Zhang L; Wang XH; Wang H; Du J; Mitch WE
Chemokine CXCL16 regulates neutrophil and macrophage infiltration into injured muscle, promoting muscle regeneration.
Am J Pathol Volume: 175 Page(s): 2518 - 2527
12/01/2009 Authors: Zhang L; Ran L; Garcia GE; Wang XH; Han S; Du J; Mitch WE
Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function.
Kidney Int Volume: 76 Page(s): 751 - 759
10/01/2009 Authors: Wang XH; Du J; Klein JD; Bailey JL; Mitch WE
Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure.
Kidney Int Volume: 75 Page(s): 617 - 625
03/01/2009 Authors: Lomashvili KA; Monier-Faugere M-C; Wang X; Malluche HH; O'Neill WC
Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency.
Endocrinology Volume: 149 Page(s): 5384 - 5390
11/01/2008 Authors: Hu J; Klein JD; Du J; Wang XH
Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids.
Endocrinology Volume: 148 Page(s): 5696 - 5705
12/01/2007 Authors: Zhou Q; Du J; Hu Z; Walsh K; Wang XH
PTEN expression contributes to the regulation of muscle protein degradation in diabetes.
Diabetes Volume: 56 Page(s): 2449 - 2456
10/01/2007 Authors: Hu Z; Lee IH; Wang X; Sheng H; Zhang L; Du J; Mitch WE
Inhibition of PI3-kinase signaling by glucocorticoids results in increased branched-chain amino acid degradation in renal epithelial cells.
Am J Physiol Cell Physiol Volume: 292 Page(s): C1874 - C1879
05/01/2007 Authors: Wang X; Hu J; Price SR
X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice.
Gene Ther Volume: 14 Page(s): 711 - 720
05/01/2007 Authors: Wang XH; Hu J; Du J; Klein JD
Frequency and characterization of ATF1-Fusion genes in angiomatoid fibrous histiocytoma
Volume: 20 Page(s): 21A - 21A
03/01/2007 Authors: Terra SBSP; Folpe AL; Weiss SW; Nascimento AG; Erickson-Johnson MR; Wang X; Oliveira AM
Frequency and characterization of ATF1-Fusion genes in angiomatoid fibrous histiocytoma
Volume: 87 Page(s): 21A - 21A
03/01/2007 Authors: Terra SBSP; Folpe AL; Weiss SW; Nascimento AG; Erickson-Johnson MR; Wang X; Oliveira AM
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling.
Endocrinology Volume: 147 Page(s): 4160 - 4168
09/01/2006 Authors: Wang X; Hu Z; Hu J; Du J; Mitch WE
Skeletal muscle proteolysis induced by Caspase-3 in uremic mice
Page(s): 1 - +
01/01/2006 Authors: Hu J; Zhou Q; Wang XH
Cardiac muscle protein catabolism in type 2 diabetic mellitus
Page(s): 45 - +
01/01/2006 Authors: Wang XH; Hu Z; Hu J; Du J
X-Chromosome linked inhibitor of apoptosis protein (XIAP) is a potential therapy agent for muscle atrophy in diabetic mice
FASEB JOURNAL Volume: 19 Page(s): A95 - A96
03/04/2005 Authors: Hu JP; Wang XH
Probing inflammatory signaling pathways in IFN-alpha-treated, HIV/HCV co-infected patients using flow cytometry
Volume: 29 Page(s): S86 - S87
12/01/2004 Authors: Alagbe O; Wang XH; Miller AH
Switching schizophrenia patients previously stable on chronic conventional antipsychotic therapy to risperidone versus olanzapine
Volume: 29 Page(s): S175 - S175
12/01/2004 Authors: Wang XH; Savage R; Borisov A; Rosenberg J; Woolwine B; Peelor M; May R; Feldman J; Miller AH
Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis.
Am J Physiol Renal Physiol Volume: 287 Page(s): F700 - F706
10/01/2004 Authors: Franch HA; Raissi S; Wang X; Zheng B; Bailey JL; Price SR
Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase.
J Am Soc Nephrol Volume: 15 Page(s): 1537 - 1545
06/01/2004 Authors: Lee SW; Dai G; Hu Z; Wang X; Du J; Mitch WE
Monitoring the migration of transplanted progenitor cells with pet and MRI.
Volume: 187 Page(s): 212 - 212
05/01/2004 Authors: Lapointe N; Bulte J; Owen M; Gross R; Chen IY; Yu M; Wang X; Owen C; Cicchetti F; Brownell AL
Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells.
Am J Physiol Renal Physiol Volume: 286 Page(s): F504 - F508
03/01/2004 Authors: Wang X; Price SR
Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions.
J Clin Invest Volume: 113 Page(s): 115 - 123
01/01/2004 Authors: Du J; Wang X; Miereles C; Bailey JL; Debigare R; Zheng B; Price SR; Mitch WE
Acidosis induces insulin resistance by blocking activation of phosphatidylinositol 3-kinase (PI 3-kinase) independently of IRS-1 activation.
Volume: 14 Page(s): 327A - 328A
11/01/2003 Authors: Franch HA; Wang X; Raissi S; Zheng B; Bailey JL; Price SR
Insulin suppresses caspase-3-mediated actin cleavage and muscle proteolysis in L6 muscle cells: Implications for uremia-induced muscle
Volume: 14 Page(s): 329A - 329A
11/01/2003 Authors: Gao Y; Debigare R; Wang X; Bailey JL; Price SR
Identification of an insulin signaling pathway that regulates branched-chain amino acid degradation in LLC-PK1-GR101 cells.
Volume: 14 Page(s): 328A - 329A
11/01/2003 Authors: Wang X; Hu J; Price SR
Antiproteolytic effects of the X-chromosome linked inhibitor of apoptosis protein (XIAP): It suppresses expression of proteasome C3 subunits via a NF-kB-related mechanism and the initial caspase-related cleavage of actomyosin.
Volume: 14 Page(s): 345A - 345A
11/01/2003 Authors: Wang XN; Du J; Mitch WE
Phosphatidylinositol 3-kinase (PI3K) suppresses branched-chain amino acid (BCAA) degradation by inhibiting branched-chain ketoacid dehydrogenase.
Volume: 13 Page(s): 502A - 502A
09/01/2002 Authors: Wang XN; Price SR
Blocking caspase-3 activation can inhibit the initial critical step in muscle protein catabolism.
Volume: 13 Page(s): 95A - 95A
09/01/2002 Authors: Wang XN; Mitch WE
Phosphatidylinositol 3-kinase activity is required for epidermal growth factor to suppress proteolysis.
J Am Soc Nephrol Volume: 13 Page(s): 903 - 909
04/01/2002 Authors: Franch HA; Wang X; Sooparb S; Brown NS; Du J
Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes.
Am J Physiol Cell Physiol Volume: 280 Page(s): C1176 - C1183
05/01/2001 Authors: Wang X; Chinsky JM; Costeas PA; Price SR
Phosphatidylinositol 3-kinase is critical for the regulation of branched-chain ketoacid dehydrogenase activity by dexamethasone in LLC-PK1-GR101 cells
Volume: 15 Page(s): A758 - A758
03/08/2001 Authors: Wang XN; Du J; Price SR
PI3-kinase activity regulates proteolysis during renal tubular cell growth.
FASEB JOURNAL Volume: 15 Page(s): A79 - A79
03/07/2001 Authors: Franch HA; Wang XN; Sooparb S; Brown NS; Du J
Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kappa B.
J Biol Chem Volume: 275 Page(s): 19661 - 19666
06/30/2000 Authors: Du J; Mitch WE; Wang X; Price SR
Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting.
Am J Physiol Volume: 276 Page(s): C1132 - C1138
05/01/1999 Authors: Mitch WE; Bailey JL; Wang X; Jurkovitz C; Newby D; Price SR
The balance between glucocorticoids and insulin regulates muscle proteolysis via the ubiquitin-proteasome pathway.
Miner Electrolyte Metab Volume: 25 Page(s): 220 - 223
01/01/1999 Authors: Bailey JL; Wang X; Price SR
Glucocorticoids and acidification independently increase transcription of branched-chain ketoacid dehydrogenase subunit genes.
Miner Electrolyte Metab Volume: 25 Page(s): 224 - 227
01/01/1999 Authors: Price SR; Wang X
Tissue-specific responses of branched-chain alpha-ketoacid dehydrogenase activity in metabolic acidosis.
J Am Soc Nephrol Volume: 9 Page(s): 1892 - 1898
10/01/1998 Authors: Price SR; Wang X; Bailey JL
Regulation of branched-chain ketoacid dehydrogenase flux by extracellular pH and glucocorticoids.
Am J Physiol Volume: 272 Page(s): C2031 - C2036
06/01/1997 Authors: Wang X; Jurkovitz C; Price SR
Signals regulating accelerated muscle protein catabolism in uremia.
Miner Electrolyte Metab Volume: 23 Page(s): 198 - 200
01/01/1997 Authors: Bailey JL; Price SR; England BK; Jurkovitz C; Wang X; Ding X; Mitch WE
Branched-chain amino acid catabolism in uremia: dual regulation of branched-chain alpha-ketoacid dehydrogenase by extracellular pH and glucocorticoids.
Miner Electrolyte Metab Volume: 23 Page(s): 206 - 209
01/01/1997 Authors: Wang X; Jurkovitz C; Price SR
Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.
J Clin Invest Volume: 98 Page(s): 1703 - 1708
10/15/1996 Authors: Price SR; Bailey JL; Wang X; Jurkovitz C; England BK; Ding X; Phillips LS; Mitch WE
Mechanisms for low levels of branched-chain amino acids in uremia: Dual regulation of branched-chain alpha-ketoacid dehydrogenase by pH and glucocorticoids.
Volume: 7 Page(s): A3103 - A3103
09/01/1996 Authors: Wang XN; Jurkovitz C; England BK; Price SR
The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.
J Clin Invest Volume: 97 Page(s): 1447 - 1453
03/15/1996 Authors: Bailey JL; Wang X; England BK; Price SR; Ding X; Mitch WE
MUSCLE PROTEOLYSIS IN CHRONIC UREMIA (CRF) - EVIDENCE FOR STIMULATION OF THE ATP-UBIQUITIN-PROTEASOME-DEPENDENT PATHWAY INCLUDING GENE-TRANSCRIPTION
Volume: 6 Page(s): 1009 - 1009
09/01/1995 Authors: BAILEY JL; WANG XN; ENGLAND BK; PRICE SR; MITCH WE
REGULATION OF THE ACTIVITY OF BRANCHED-CHAIN KETOACID DEHYDROGENASE (BCKAD) ACTIVITY - EVIDENCE FOR INDEPENDENT EFFECTS OF PH AND GLUCOCORTICOIDS
Volume: 6 Page(s): 1034 - 1034
09/01/1995 Authors: WANG XN; JURKOVITZ C; ENGLAND BK; PRICE SR; MITCH WE
Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase.
Am J Physiol Volume: 268 Page(s): F671 - F679
04/01/1995 Authors: Lien YH; Wang X; Gillies RJ; Martinez-Zaguilan R
Calcium modulation and cell injury in isolated rat proximal tubules.
J Pharmacol Exp Ther Volume: 267 Page(s): 176 - 180
10/01/1993 Authors: Wetzels JF; Yu L; Wang X; Kribben A; Burke TJ; Schrier RW
Divergent effects of acute and chronic ethanol exposure on contraction and Ca2+ mobilization in cultured vascular smooth muscle cells.
Am J Hypertens Volume: 6 Page(s): 268 - 275
04/01/1993 Authors: Briner VA; Tsai P; Wang X; Schrier RW
Parathyroid hormone inhibition of vasopressin-induced vascular smooth muscle contraction.
Am J Physiol Volume: 264 Page(s): F453 - F457
03/01/1993 Authors: Wang X; Briner VA; Schrier RW
An evaluation of the renal protective effect of manidipine in the uninephrectomized spontaneously hypertensive rat.
Am Heart J Volume: 125 Page(s): 620 - 625
02/01/1993 Authors: Reams GP; Villarreal D; Wu Z; Wang X; Luger AM; Bauer JH
Glycine protection against hypoxic but not phospholipase A2-induced injury in rat proximal tubules.
Am J Physiol Volume: 264 Page(s): F94 - F99
01/01/1993 Authors: Wetzels JF; Wang X; Gengaro PE; Nemenoff RA; Burke TJ; Schrier RW
ROLE OF CALCIUM IN INJURY OF ISOLATED RAT PROXIMAL TUBULES
Volume: 40 Page(s): A217 - A217
04/01/1992 Authors: YU L; WETZELS JFM; WANG XN; BURKE TJ; SCHRIER RW
PARATHYROID-HORMONE (PTH) EFFECT ON ARGININE VASOPRESSIN (AVP)-INDUCED CONTRACTION AND SIGNAL TRANSDUCTION IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELL (VSMC)
Volume: 39 Page(s): A270 - A270
04/01/1991 Authors: WANG XN; BRINER VA; SCHRIER RW

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