Xi Lin PhD

Department of Otolaryngology Head and Neck Surgery
Professor Emeritus

(404) 727-3723
xlin2@emory.edu

Overview

Xi Lin completed his PhD degree at the University of Michigan (1993). Prior to joining the faculty at Emory, Dr. Lin was a Postdoctoral Research Associate in Molecular Cardiology Laboratory, Department of Medicine at the University of Chicago (1994) and a Postdoctoral Research Associate Auditory Physiology Lab at the Northwestern University, also in Chicago (1996). His articles have been published in a number of leading journals including the Journal of the Acoustical Society of America, British Journal of Pharmacology, and Microvascular Research. Dr. Lin serves as a Professor and Research Director for the Department of Otolaryngology- Head and Neck Surgery located at Emory University School of Medicine.

Academic Appointment

Professor, Department of Otolaryngology, Emory University
Associate Professor, Dept of Cell Biology, Emory University

Education

Degrees

PhD from University of Michigan
MS from Shanghai Institute of Physiology, Chinese Academy of Sciences
BS from University of Science and Technology of China

Research

Focus

We study mechanisms of genetic deafness caused by connexin and pendrin mutations, which are the most commonly-found mutations responsible for >50% of the human congenital deafness cases in newborns. Focus is to understand how membrane channels/receptors contribute to the normal cochlear physiology and homeostasis and to conduct related translational researches.

Publications

Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti.
eNeuro Volume: 10
06/01/2023 Authors: Knapp L; Sun H; Wang Y-M; Chen B-J; Lin X; Gao N; Chen P; Ren D
Corrigendum: Virally mediated connexin 26 expression in postnatal scala media significantly and transiently preserves hearing in connexin 30 null mice.
Front Cell Dev Biol Volume: 10 Page(s): 969989
01/01/2022 Authors: Zhang L; Wang W; Kim SM; Wang J; Zhou B; Kong W; Zheng J; Lin X
Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice.
Front Cell Dev Biol Volume: 10 Page(s): 900416
01/01/2022 Authors: Zhang L; Wang W; Kim SM; Wang J; Zhou B; Kong W; Zheng J; Lin X
Analysis of the effects and predictors of tailor-made notched music therapy for chronic idiopathic tinnitus patients: Our experience with 70 patients.
Clin Otolaryngol Volume: 46 Page(s): 630 - 634
05/01/2021 Authors: Diao M; Tian R; Tian F; Lin X; Sun J
Planar cell polarity governs the alignment of the nasopharyngeal epithelium in mammals.
FEBS J Volume: 288 Page(s): 1027 - 1040
02/01/2021 Authors: Luo W-W; Chen B-J; Wang Y-M; Yang J-M; Liu X; Yuan Y-S; Lin X; Chi F-L; Chen P; Ren D-D
Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2.
Nat Commun Volume: 12 Page(s): 697
01/29/2021 Authors: Wu X; Zhang L; Li Y; Zhang W; Wang J; Cai C; Lin X
Gene therapy for genetic mutations affecting non-sensory cells in the cochlea.
Hear Res Volume: 394 Page(s): 107858
09/01/2020 Authors: Zhang L; Wu X; Lin X
Mutations in the Scn8a DIIS4 voltage sensor reveal new distinctions among hypomorphic and null Nav 1.6 sodium channels.
Genes Brain Behav Volume: 19 Page(s): e12612
04/01/2020 Authors: Inglis GAS; Wong JC; Butler KM; Thelin JT; Mistretta OC; Wu X; Lin X; English AW; Escayg A
Comprehensive genetic testing of Chinese SNHL patients and variants interpretation using ACMG guidelines and ethnically matched normal controls.
Eur J Hum Genet Volume: 28 Page(s): 231 - 243
02/01/2020 Authors: Yuan Y; Li Q; Su Y; Lin Q; Gao X; Liu H; Huang S; Kang D; Todd NW; Mattox D
Expression pattern of Connexin 26 and Connexin 30 in mature cochlea of the monkey.
Biochem Biophys Res Commun Volume: 518 Page(s): 357 - 361
10/15/2019 Authors: Wu X; Tang W; Muly EC; Zhang L; Lin X
Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear.
Mol Biol Cell Volume: 30 Page(s): 2422 - 2434
08/15/2019 Authors: Tower-Gilchrist C; Zlatic SA; Yu D; Chang Q; Wu H; Lin X; Faundez V; Chen P
Next-Generation Glycan Microarray Enabled by DNA-Coded Glycan Library and Next-Generation Sequencing Technology.
Anal Chem Volume: 91 Page(s): 9221 - 9228
07/16/2019 Authors: Yan M; Zhu Y; Liu X; Lasanajak Y; Xiong J; Lu J; Lin X; Ashline D; Reinhold V; Smith DF
Structure and Function of Cochlear Gap Junctions and Implications for the Translation of Cochlear Gene Therapies.
Front Cell Neurosci Volume: 13 Page(s): 529
01/01/2019 Authors: Wu X; Zhang W; Li Y; Lin X
The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival.
Cell Death Dis Volume: 9 Page(s): 1180
12/05/2018 Authors: Chen S; Xu K; Xie L; Cao H-Y; Wu X; Du A-N; He Z-H; Lin X; Sun Y; Kong W-J
A Missense Mutation in POU4F3 Causes Midfrequency Hearing Loss in a Chinese ADNSHL Family.
Biomed Res Int Volume: 2018 Page(s): 5370802
01/01/2018 Authors: Gao X; Xu J-C; Wang W-Q; Yuan Y-Y; Bai D; Huang S-S; Wang G-J; Su Y; Li J; Kang D-Y
Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.
Biomed Res Int Volume: 2018 Page(s): 7817453
01/01/2018 Authors: Chen B; Wang Y; Geng M; Lin X; Tang W
Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success.
Front Mol Neurosci Volume: 11 Page(s): 221
01/01/2018 Authors: Zhang W; Kim SM; Wang W; Cai C; Feng Y; Kong W; Lin X
Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity.
Sci Rep Volume: 7 Page(s): 45870
03/30/2017 Authors: Luo W; Yi H; Taylor J; Li J-D; Chi F; Todd NW; Lin X; Ren D; Chen P
Novel Mutations and Mutation Combinations of TMPRSS3 Cause Various Phenotypes in One Chinese Family with Autosomal Recessive Hearing Impairment.
Biomed Res Int Volume: 2017 Page(s): 4707315
01/01/2017 Authors: Gao X; Yuan Y-Y; Wang G-J; Xu J-C; Su Y; Lin X; Dai P
Spatial and Age-Dependent Hair Cell Generation in the Postnatal Mammalian Utricle.
Mol Neurobiol Volume: 53 Page(s): 1601 - 1612
04/01/2016 Authors: Gao Z; Kelly MC; Yu D; Wu H; Lin X; Chi F-L; Chen P
Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice.
Sci Rep Volume: 6 Page(s): 22573
03/03/2016 Authors: Sun Y; Yu J; Lin X; Tang W
Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin Mice.
Int J Mol Sci Volume: 17 Page(s): 301
02/26/2016 Authors: Zhou X-X; Chen S; Xie L; Ji Y-Z; Wu X; Wang W-W; Yang Q; Yu J-T; Sun Y; Lin X
Phenotypic Heterogeneity in a DFNA20/26 family segregating a novel ACTG1 mutation.
BMC Genet Volume: 17 Page(s): 33
02/01/2016 Authors: Yuan Y; Gao X; Huang B; Lu J; Wang G; Lin X; Qu Y; Dai P
Characterization of ATPase Activity of P2RX2 Cation Channel.
Front Physiol Volume: 7 Page(s): 186
01/01/2016 Authors: Mittal R; Grati M; Sedlacek M; Yuan F; Chang Q; Yan D; Lin X; Kachar B; Farooq A; Chapagain P
Targeted gene capture and massively parallel sequencing identify TMC1 as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss.
Am J Med Genet A Volume: 167A Page(s): 2357 - 2365
10/01/2015 Authors: Gao X; Huang S-S; Yuan Y-Y; Wang G-J; Xu J-C; Ji Y-B; Han M-Y; Yu F; Kang D-Y; Lin X
Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange-Nielsen deafness syndrome.
EMBO Mol Med Volume: 7 Page(s): 1077 - 1086
08/01/2015 Authors: Chang Q; Wang J; Li Q; Kim Y; Zhou B; Wang Y; Li H; Lin X
Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing.
Neurobiol Dis Volume: 73 Page(s): 418 - 427
01/01/2015 Authors: Chang Q; Tang W; Kim Y; Lin X
De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.
Cell Res Volume: 24 Page(s): 1370 - 1373
11/01/2014 Authors: Yuan Y; Zhang J; Chang Q; Zeng J; Xin F; Wang J; Zhu Q; Wu J; Lu J; Guo W
Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose.
Biochem Biophys Res Commun Volume: 452 Page(s): 340 - 346
09/26/2014 Authors: Wu X; Wang Y; Sun Y; Chen S; Zhang S; Shen L; Huang X; Lin X; Kong W
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Cell Death Dis Volume: 5 Page(s): e1284
06/05/2014 Authors: Yue X; Yang X; Lin X; Yang T; Yi X; Dai Y; Guo J; Li T; Shi J; Wei L
Down regulated connexin26 at different postnatal stage displayed different types of cellular degeneration and formation of organ of Corti.
Biochem Biophys Res Commun Volume: 445 Page(s): 71 - 77
02/28/2014 Authors: Chen S; Sun Y; Lin X; Kong W
Novel compound heterozygous mutations in MYO7A Associated with Usher syndrome 1 in a Chinese family.
PLoS One Volume: 9 Page(s): e103415
01/01/2014 Authors: Gao X; Wang G-J; Yuan Y-Y; Xin F; Han M-Y; Lu J-Q; Zhao H; Yu F; Xu J-C; Zhang M-G
Combined examination of sequence and copy number variations in human deafness genes improves diagnosis for cases of genetic deafness.
BMC Ear Nose Throat Disord Volume: 14 Page(s): 9
01/01/2014 Authors: Ji H; Lu J; Wang J; Li H; Lin X
Differences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and mice.
PLoS One Volume: 8 Page(s): e64906
01/01/2014 Authors: Lu Y-C; Wu C-C; Yang T-H; Lin Y-H; Yu I-S; Lin S-W; Chang Q; Lin X; Wong J-M; Hsu C-J
Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice.
Gene Ther Volume: 21 Page(s): 71 - 80
01/01/2014 Authors: Yu Q; Wang Y; Chang Q; Wang J; Gong S; Li H; Lin X
Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.
J Neurosci Volume: 33 Page(s): 13042 - 13052
08/07/2013 Authors: Yu Q; Chang Q; Liu X; Wang Y; Li H; Gong S; Ye K; Lin X
Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 8236 - 8241
05/14/2013 Authors: Lin X; Liu B; Yang X; Yue X; Diao L; Wang J; Chang J
Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstem response thresholds.
J Gene Med Volume: 15 Page(s): 123 - 133
01/01/2013 Authors: Wang Y; Sun Y; Chang Q; Ahmad S; Zhou B; Kim Y; Li H; Lin X
An intragenic SRF-dependent regulatory motif directs cardiac-specific microRNA-1-1/133a-2 expression.
PLoS One Volume: 8 Page(s): e75470
01/01/2013 Authors: Li Q; Guo J; Lin X; Yang X; Ma Y; Fan G-C; Chang J
Genetics of hearing and deafness.
Anat Rec (Hoboken) Volume: 295 Page(s): 1812 - 1829
11/01/2012 Authors: Angeli S; Lin X; Liu XZ
7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo.
Biochem Biophys Res Commun Volume: 422 Page(s): 387 - 392
06/08/2012 Authors: Yu Q; Chang Q; Liu X; Gong S; Ye K; Lin X
Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities.
Hear Res Volume: 288 Page(s): 67 - 76
06/01/2012 Authors: Lin X; Tang W; Ahmad S; Lu J; Colby CC; Zhu J; Yu Q
A low-cost exon capture method suitable for large-scale screening of genetic deafness by the massively-parallel sequencing approach.
Genet Test Mol Biomarkers Volume: 16 Page(s): 536 - 542
06/01/2012 Authors: Tang W; Qian D; Ahmad S; Mattox D; Todd NW; Han H; Huang S; Li Y; Wang Y; Li H
Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo.
J Neurosci Volume: 32 Page(s): 6699 - 6710
05/09/2012 Authors: Kelly MC; Chang Q; Pan A; Lin X; Chen P
Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.
FASEB J Volume: 26 Page(s): 2105 - 2116
05/01/2012 Authors: Yang X; Li Q; Lin X; Ma Y; Yue X; Tao Z; Wang F; Mckeehan WL; Wei L; Schwartz RJ
Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions.
Biochem Biophys Res Commun Volume: 417 Page(s): 245 - 250
01/06/2012 Authors: Qu Y; Tang W; Zhou B; Ahmad S; Chang Q; Li X; Lin X
Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.
Mol Cell Biol Volume: 32 Page(s): 297 - 308
01/01/2012 Authors: Lin X; Yang X; Li Q; Ma Y; Cui S; He D; Lin X; Schwartz RJ; Chang J
Perception of sound and gravity by TMC1 and TMC2.
J Clin Invest Volume: 121 Page(s): 4633 - 4636
12/01/2011 Authors: Lin X
Establishment of a knock-in mouse model with the SLC26A4 c.919-2A>G mutation and characterization of its pathology.
PLoS One Volume: 6 Page(s): e22150
01/01/2011 Authors: Lu Y-C; Wu C-C; Shen W-S; Yang T-H; Yeh T-H; Chen P-J; Yu I-S; Lin S-W; Wong J-M; Chang Q
Functional evaluation of GJB2 variants in nonsyndromic hearing loss.
Mol Med Volume: 17 Page(s): 550 - 556
01/01/2011 Authors: Choi S-Y; Lee KY; Kim H-J; Kim H-K; Chang Q; Park H-J; Jeon C-J; Lin X; Bok J; Kim U-K
Deoxygedunin, a natural product with potent neurotrophic activity in mice.
PLoS One Volume: 5 Page(s): e11528
07/13/2010 Authors: Jang S-W; Liu X; Chan CB; France SA; Sayeed I; Tang W; Lin X; Xiao G; Andero R; Chang Q
NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression.
Am J Physiol Heart Circ Physiol Volume: 298 Page(s): H1340 - H1347
05/01/2010 Authors: Li Q; Lin X; Yang X; Chang J
Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.
J Comp Neurol Volume: 516 Page(s): 569 - 579
10/20/2009 Authors: Sun Y; Tang W; Chang Q; Wang Y; Kong W; Lin X
Targeted connexin26 ablation arrests postnatal development of the organ of Corti.
Biochem Biophys Res Commun Volume: 385 Page(s): 33 - 37
07/17/2009 Authors: Wang Y; Chang Q; Tang W; Sun Y; Zhou B; Li H; Lin X
Different functional consequences of two missense mutations in the GJB2 gene associated with non-syndromic hearing loss.
Hum Mutat Volume: 30 Page(s): E716 - E727
07/01/2009 Authors: Choi S-Y; Park H-J; Lee KY; Dinh EH; Chang Q; Ahmad S; Lee SH; Bok J; Lin X; Kim U-K
Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models.
Brain Res Volume: 1277 Page(s): 52 - 69
06/24/2009 Authors: Hoang Dinh E; Ahmad S; Chang Q; Tang W; Stong B; Lin X
Functional studies reveal new mechanisms for deafness caused by connexin mutations.
Otol Neurotol Volume: 30 Page(s): 237 - 240
02/01/2009 Authors: Chang Q; Tang W; Ahmad S; Stong B; Leu G; Lin X
Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31.
Hum Genet Volume: 125 Page(s): 53 - 62
02/01/2009 Authors: Liu X-Z; Yuan Y; Yan D; Ding EH; Ouyang XM; Fei Y; Tang W; Yuan H; Chang Q; Du LL
Pannexins are new molecular candidates for assembling gap junctions in the cochlea.
Neuroreport Volume: 19 Page(s): 1253 - 1257
08/27/2008 Authors: Tang W; Ahmad S; Shestopalov VI; Lin X
The cochlear pericytes.
Microcirculation Volume: 15 Page(s): 515 - 529
08/01/2008 Authors: Shi X; Han W; Yamamoto H; Tang W; Lin X; Xiu R; Trune DR; Nuttall AL
Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice.
PLoS One Volume: 3 Page(s): e4088
01/01/2008 Authors: Chang Q; Tang W; Ahmad S; Zhou B; Lin X
Analysis of connexin subunits required for the survival of vestibular hair cells.
J Comp Neurol Volume: 504 Page(s): 499 - 507
10/10/2007 Authors: Qu Y; Tang W; Dahlke I; Ding D; Salvi R; Shl G; Willecke K; Chen P; Lin X
Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.
Proc Natl Acad Sci U S A Volume: 104 Page(s): 1337 - 1341
01/23/2007 Authors: Ahmad S; Tang W; Chang Q; Qu Y; Hibshman J; Li Y; Shl G; Willecke K; Chen P; Lin X
A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels.
Laryngoscope Volume: 116 Page(s): 2205 - 2210
12/01/2006 Authors: Stong BC; Chang Q; Ahmad S; Lin X
Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice.
J Neurosci Volume: 26 Page(s): 1991 - 1999
02/15/2006 Authors: Tang W; Zhang Y; Chang Q; Ahmad S; Dahlke I; Yi H; Chen P; Paul DL; Lin X
Neuromodulation in the spiral ganglion: shaping signals from the organ of corti to the CNS.
J Membr Biol Volume: 209 Page(s): 167 - 175
01/01/2006 Authors: Dulon D; Jagger DJ; Lin X; Davis RL
Changes in gap junctional connexin isoforms during prostate cancer progression.
Prostate Volume: 66 Page(s): 19 - 31
01/01/2006 Authors: Tate AW; Lung T; Radhakrishnan A; Lim SD; Lin X; Edlund M
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions.
Proc Natl Acad Sci U S A Volume: 102 Page(s): 15201 - 15206
10/18/2005 Authors: Zhang Y; Tang W; Ahmad S; Sipp JA; Chen P; Lin X
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
Nat Genet Volume: 37 Page(s): 980 - 985
09/01/2005 Authors: Wang J; Mark S; Zhang X; Qian D; Yoo S-J; Radde-Gallwitz K; Zhang Y; Lin X; Collazo A; Wynshaw-Boris A
Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts.
Am J Physiol Cell Physiol Volume: 288 Page(s): C613 - C623
03/01/2005 Authors: Sun J; Ahmad S; Chen S; Tang W; Zhang Y; Chen P; Lin X
Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice.
J Neurosci Volume: 24 Page(s): 10167 - 10175
11/10/2004 Authors: Peng B-G; Ahmad S; Chen S; Chen P; Price MP; Lin X
Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear.
J Comp Neurol Volume: 477 Page(s): 412 - 421
09/27/2004 Authors: Radde-Gallwitz K; Pan L; Gan L; Lin X; Segil N; Chen P
Group I metabotropic glutamate receptors in spiral ganglion neurons contribute to excitatory neurotransmissions in the cochlea.
Neuroscience Volume: 123 Page(s): 221 - 230
01/01/2004 Authors: Peng BG; Li QX; Ren TY; Ahmad S; Chen SP; Chen P; Lin X
Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice.
Biochem Biophys Res Commun Volume: 307 Page(s): 362 - 368
07/25/2003 Authors: Ahmad S; Chen S; Sun J; Lin X
Aspirin selectively augmented N-methyl-D-aspartate types of glutamate responses in cultured spiral ganglion neurons of mice.
Neurosci Lett Volume: 343 Page(s): 21 - 24
05/29/2003 Authors: Peng B-G; Chen S; Lin X
Optical recordings of Ca2+ signaling activities from identified inner ear cells in cochlear slices and hemicochleae.
Brain Res Brain Res Protoc Volume: 11 Page(s): 92 - 100
05/01/2003 Authors: Lin X; Webster P; Li Q; Chen S; Ouyang Y
Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.
Hear Res Volume: 165 Page(s): 85 - 95
03/01/2002 Authors: Huang D; Chen P; Chen S; Nagura M; Lim DJ; Lin X
Computer-simulation studies on roles of potassium currents in neurotransmission of the auditory nerve.
Hear Res Volume: 152 Page(s): 90 - 99
02/01/2001 Authors: Lin X; Hant J
Activation of metabotropic GABAB receptors inhibited glutamate responses in spiral ganglion neurons of mice.
Neuroreport Volume: 11 Page(s): 957 - 961
04/07/2000 Authors: Lin X; Chen S; Chen P
Endogenously generated spontaneous spiking activities recorded from postnatal spiral ganglion neurons in vitro.
Brain Res Dev Brain Res Volume: 119 Page(s): 297 - 305
02/07/2000 Authors: Lin X; Chen S
Effects of quinine on the excitability and voltage-dependent currents of isolated spiral ganglion neurons in culture.
J Neurophysiol Volume: 79 Page(s): 2503 - 2512
05/01/1998 Authors: Lin X; Chen S; Tee D
The mechanism and site of action of lidocaine hydrochloride in guinea pig inner ear.
Acta Otolaryngol Volume: 117 Page(s): 523 - 528
07/01/1997 Authors: Laurikainen E; Lin X; Nuttall AL; Dolan DF
Action potentials and underlying voltage-dependent currents studied in cultured spiral ganglion neurons of the postnatal gerbil.
Hear Res Volume: 108 Page(s): 157 - 179
06/01/1997 Authors: Lin X
Acetylcholine, outer hair cell electromotility, and the cochlear amplifier.
J Neurosci Volume: 17 Page(s): 2212 - 2226
03/15/1997 Authors: Dallos P; He DZ; Lin X; Sziklai I; Mehta S; Evans BN
A novel, simple organotypic culture method to study the organ of Corti from the neonatal gerbil.
ORL J Otorhinolaryngol Relat Spec Volume: 59 Page(s): 243 - 247
01/01/1997 Authors: Liu TC; He DZ; Lin X
Dihydropyridines and verapamil inhibit voltage-dependent K+ current in isolated outer hair cells of the guinea pig.
Hear Res Volume: 88 Page(s): 36 - 46
08/01/1995 Authors: Lin X; Hume RI; Nuttall AL
Polarized-light intravital microscopy for study of cochlear microcirculation.
Microvasc Res Volume: 46 Page(s): 383 - 393
11/01/1993 Authors: Ren T; Lin X; Nuttall AL
Voltage-dependent block by neomycin of the ATP-induced whole cell current of guinea-pig outer hair cells.
J Neurophysiol Volume: 70 Page(s): 1593 - 1605
10/01/1993 Authors: Lin X; Hume RI; Nuttall AL
A receptor that is highly specific for extracellular ATP in developing chick skeletal muscle in vitro.
Br J Pharmacol Volume: 103 Page(s): 1963 - 1969
08/01/1991 Authors: Thomas SA; Zawisa MJ; Lin X; Hume RI

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