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Profile

Susan Wall MD

  • Department of Medicine
    Professor
  • (404) 727-2525
  • smwall@emory.edu
  • Emory University School of Medicine
    Medicine
    101 Woodruff Circle NE
Head shot of Susan Wall

Overview

Dr. Susan Wall received an Honors BS in chemistry from the University of Washington and an MD from St. Louis University School of Medicine. She did her internship and residency at the UCLA San Fernando Valley Program and then completed a clinical and research fellowship in nephrology at UCLA. During her fellowship at UCLA, she became interested in the physiology of the renal regulation of acid-base balance. She extended her laboratory training by doing a second research fellowship at the Kidney and Electrolyte Laboratory of the National Heart, Lung and Blood Institute at the National Institutes of Health. She then joined the Nephrology Division at the University of Texas, Health Science Center at Houston, where she rose from assistant to associate professor. She came to Emory in 2002 and is now a professor of medicine. Her laboratory initially studied the role of ammonium transport along the collecting duct and its role in the renal regulation of acid-base balance. More recently, her research involves the study renal Cl-transporters and their role in the regulation of blood pressure as well as sodium, potassium and chloride balance.

Dr. Walls laboratory has made major contributions to our understanding of the renal regulation of acid-base balance. They were the first to characterize direct, transepithelial transport of ammonium (NH4+) along the collecting duct. Previously it was believed that NH4+ secretion along the collecting duct occurs exclusively through active H+ secretion in parallel with the nonionic diffusion of NH3. Wall and colleagues observed direct NH4+ transport along the collecting duct, mediated by the Na,K-ATPase. She observed that Na,K-ATPase-mediated NH4+ uptake represents 50% of net acid secreted along the terminal inner medullary collecting duct during hypokalemia, which contributes to the metabolic alkalosis observed in this treatment model. Because NH4+ is the major regulatable component of net acid secretion, these observations provide an important and novel mechanism for the renal regulation of net acid secretion.
More recently, Dr. Wall has studied the contribution of renal Cl-transporters to the maintenance of vascular volume, blood pressure as well as sodium, potassium, chloride and acid-base balance. She and her colleagues have localized the Cl-/HCO3- exchanger pendrin (Slc26a4) to the apical region of subpopulations of intercalated cells within the distal nephron. Pendrin, she observed, is upregulated following aldosterone, primarily by changing the subcellular distribution of pendrin from the subapical space to the apical plasma membrane. Pendrin mediates HCO3- secretion and Cl- absorption, which reduces arterial pH and expands vascular volume, thereby increasing blood pressure. The Wall Laboratory first described the novel role of pendrin in blood pressure regulation. Pendrin plays an important role in the hypertensive response to aldosterone by increasing the renal absorption of Cl-. Her laboratory also observed that pendrin modulates the abundance and function of the epithelial sodium channel, ENaC, which helps maintain potassium balance.

Dr. Wall has attended on the renal consult service at Emory University Hospital. Her main clinical interests are in the pathophysiology of acid-base and blood pressure regulation. She is also interested in the removal of drugs through dialysis.

Dr. Wall now serves as a regular member of the National Institutes of Health Kidney Study Sections (CMBK, 2003-2007 and KUFD 2022-2026). She is a member of numerous national medical societies such as the American Society for Clinical Investigation (ASCI), the Association of American Physicians (AAP), the American Society of Nephrology (ASN) and the American Physiological Society (APS). She was chair of the American Society of Nephrology Kidney Week Program Committee (2017). Finally, Dr. Wall has received numerous awards including the American Physiological Society Robert W. Berliner Award (2023), The American Physiological Society Carl W. Gottschalk Distinguished Lectureship Award (2014), The American Heart Association Donald Seldin Lecturer (2020), The American Heart Association Distinguished Achievement Award (2023), and the American Society of Nephrology Barry M. Brenner Endowed Lecturer (2011).

Academic Appointment

  • Professor of Medicine and Physiology with tenure, Emory University School of Medicine
  • Professor of Medicine and Physiology, Emory University School of Medicine

Education

Degrees

  • MD from St. Louis University
  • BS from The University of Washington

Research

Publications

  • Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake.
    Sci Rep Volume: 14 Page(s): 10740
    05/10/2024 Authors: Jung HJ; Pham TD; Su X-T; Grigore TV; Hoenderop JG; Olauson H; Wall SM; Ellison DH; Welling PA; Al-Qusairi L
  • Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.
    Am J Physiol Renal Physiol Volume: 326 Page(s): F202 - F218
    02/01/2024 Authors: Pham TD; Verlander JW; Chen C; Pech V; Kim HI; Kim YH; Weiner ID; Milne GL; Zent R; Bock F
  • Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.
    bioRxiv
    12/06/2023 Authors: Romero CA; Lim J; Wang H; Wynne BM; Ma P; Jing Y; Liotta DC; D'Erasmo M; Traynelis SF; Eaton DC
  • Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect.
    Am J Physiol Renal Physiol Volume: 325 Page(s): F377 - F393
    09/01/2023 Authors: Al-Qusairi L; Ferdaus MZ; Pham TD; Li D; Grimm PR; Zapf AM; Abood DC; Tahaei E; Delpire E; Wall SM
  • Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.
    Am J Physiol Cell Physiol Volume: 324 Page(s): C1171 - C1178
    05/01/2023 Authors: Ferdaus MZ; Terker AS; Koumangoye R; Wall SM; Delpire E
  • Pendrin abundance, subcellular distribution, and function are unaffected by either ENaC gene ablation or by increasing ENaC channel activity.
    Pflugers Arch Volume: 475 Page(s): 607 - 620
    05/01/2023 Authors: Loffing J; Pech V; Loffing-Cueni D; Abood DC; Kim YH; Chen C; Pham TD; Verlander JW; Wall SM
  • Pendrin regulation is prioritized by anion in high-potassium diets.
    Am J Physiol Renal Physiol Volume: 324 Page(s): F256 - F266
    03/01/2023 Authors: Tahaei E; Pham TD; Al-Qusairi L; Grimm R; Wall SM; Welling PA
  • The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis.
    Am J Physiol Renal Physiol Volume: 324 Page(s): F12 - F29
    01/01/2023 Authors: Verlander JW; Lee H-W; Wall SM; Harris AN; Weiner ID
  • Loop-Diuretics Increase Pendrin through alpha-ketoglutarate receptor, Oxgr1.
    FASEB J Volume: 36 Suppl 1
    05/01/2022 Authors: Tahaei SE; Wall S; Welling PA
  • Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC.
    Am J Physiol Renal Physiol Volume: 322 Page(s): F486 - F497
    05/01/2022 Authors: Pham TD; Elengickal AJ; Verlander JW; Al-Qusairi L; Chen C; Abood DC; King SA; Loffing J; Welling PA; Wall SM
  • Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020.
    Hypertension Volume: 79 Page(s): 706 - 716
    04/01/2022 Authors: Wall SM
  • Effects of Roxadustat on Erythropoietin Production in the Rat Body.
    Molecules Volume: 27
    02/08/2022 Authors: Yasuoka Y; Izumi Y; Fukuyama T; Omiya H; Pham TD; Inoue H; Oshima T; Yamazaki T; Uematsu T; Kobayashi N
  • Changing Demographics of NIDDK-Funded Physician-Scientists Doing Kidney Research.
    Clin J Am Soc Nephrol Volume: 16 Page(s): 1337 - 1344
    09/01/2021 Authors: Abood DC; King SA; Eaton DC; Wall SM
  • Thrombocytopenia Induced by Polysulfone Dialysis Membranes.
    Am J Case Rep Volume: 22 Page(s): e932045
    07/03/2021 Authors: Claudio-Gonzalez I; Ravindranathan D; Kempton CL; Bailey JL; Wall SM
  • The Renal Physiology of Pendrin-Positive Intercalated Cells.
    Physiol Rev Volume: 100 Page(s): 1119 - 1147
    07/01/2020 Authors: Wall SM; Verlander JW; Romero CA
  • Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
    J Clin Invest Volume: 130 Page(s): 3734 - 3749
    07/01/2020 Authors: Battistone MA; Mendelsohn AC; Spallanzani RG; Allegretti AS; Liberman RN; Sesma J; Kalim S; Wall SM; Bonventre JV; Lazarowski ER
  • Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor-Dependent and -Independent Mechanisms over a Wide Range in Serum Potassium.
    J Am Soc Nephrol Volume: 31 Page(s): 483 - 499
    03/01/2020 Authors: Pham TD; Verlander JW; Wang Y; Romero CA; Yue Q; Chen C; Thumova M; Eaton DC; Lazo-Fernandez Y; Wall SM
  • Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol.
    Physiol Rep Volume: 6 Page(s): e13904
    11/01/2018 Authors: Park AY; Plotsky PM; Pham TD; Pacak K; Wynne BM; Wall SM; Lazo-Fernandez Y
  • -Ketoglutarate stimulates pendrin-dependent Cl- absorption in the mouse CCD through protein kinase C.
    Am J Physiol Renal Physiol Volume: 315 Page(s): F7 - F15
    07/01/2018 Authors: Lazo-Fernandez Y; Welling PA; Wall SM
  • The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.
    J Am Soc Nephrol Volume: 29 Page(s): 1706 - 1719
    06/01/2018 Authors: Nanami M; Pham TD; Kim YH; Yang B; Sutliff RL; Staub O; Klein JD; Lopez-Cayuqueo KI; Chambrey R; Park AY
  • Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): E351 - E352
    01/16/2018 Authors: Chen L; Lee JW; Chou C-L; Nair AV; Battistone MA; Punescu TG; Merkulova M; Breton S; Verlander JW; Wall SM
  • Renal intercalated cells and blood pressure regulation.
    Kidney Res Clin Pract Volume: 36 Page(s): 305 - 317
    12/01/2017 Authors: Wall SM
  • Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
    Proc Natl Acad Sci U S A Volume: 114 Page(s): E9989 - E9998
    11/14/2017 Authors: Chen L; Lee JW; Chou C-L; Nair AV; Battistone MA; Punescu TG; Merkulova M; Breton S; Verlander JW; Wall SM
  • Alpha-ketoglutarate stimulates Cl- absorption in the mouse CCD through a mechanism dependent on pendrin and protein kinase C
    Volume: 31
    04/01/2017 Authors: Fernandez YL; Welling PA; Wall SM
  • NEDD4-2 reduces electroneutral Cl-/HCO3- exchange in mouse cortical collecting duct
    Volume: 30
    04/01/2016 Authors: Truyen DP; Nanami M; Staub O; Sutliff RL; Klein JD; Eladari D; Chambrey R; Wang X; Verlander JW; Wall SM
  • The role of pendrin in blood pressure regulation.
    Am J Physiol Renal Physiol Volume: 310 Page(s): F193 - F203
    02/01/2016 Authors: Wall SM
  • Pendrin localizes to the adrenal medulla and modulates catecholamine release (vol 309, pg 534, 2015)
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM Volume: 309 Page(s): E885 - E885
    11/15/2015 Authors: Lazo-Fernandez Y; Aguilera G; Pham TD; Park AY; Beierwaltes WH; Sutliff RL; Verlander JW; Pacak K; Osunkoya AO; Ellis CL
  • The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat.
    Exp Physiol Volume: 100 Page(s): 1177 - 1186
    10/01/2015 Authors: West CA; Verlander JW; Wall SM; Baylis C
  • ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion.
    Am J Physiol Renal Physiol Volume: 309 Page(s): F251 - F258
    08/01/2015 Authors: Nanami M; Lazo-Fernandez Y; Pech V; Verlander JW; Agazatian D; Weinstein AM; Bao H-F; Eaton DC; Wall SM
  • ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. II. Bafilomycin-sensitive H+ secretion.
    Am J Physiol Renal Physiol Volume: 309 Page(s): F259 - F268
    08/01/2015 Authors: Nanami M; Pech V; Lazo-Fernandez Y; Weinstein AM; Wall SM
  • Pendrin gene ablation alters ENaC subcellular distribution and open probability.
    Am J Physiol Renal Physiol Volume: 309 Page(s): F154 - F163
    07/15/2015 Authors: Pech V; Wall SM; Nanami M; Bao H-F; Kim YH; Lazo-Fernandez Y; Yue Q; Pham TD; Eaton DC; Verlander JW
  • Integrated compensatory network is activated in the absence of NCC phosphorylation.
    J Clin Invest Volume: 125 Page(s): 2136 - 2150
    05/01/2015 Authors: Grimm PR; Lazo-Fernandez Y; Delpire E; Wall SM; Dorsey SG; Weinman EJ; Coleman R; Wade JB; Welling PA
  • Activation of a Novel Adaptive Mechanism Limits Renal Salt Wasting During Thiazide Inhibition of the Sodium Chloride Cotransporter (NCC)
    Volume: 29
    04/01/2015 Authors: Grimm P; Wall S; Delpire E; Welling P
  • The role of pendrin in renal physiology.
    Annu Rev Physiol Volume: 77 Page(s): 363 - 378
    01/01/2015 Authors: Wall SM; Lazo-Fernandez Y
  • Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.
    Infect Immun Volume: 82 Page(s): 4212 - 4221
    10/01/2014 Authors: Scanlon KM; Gau Y; Zhu J; Skerry C; Wall SM; Soleimani M; Carbonetti NH
  • Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.
    PLoS One Volume: 9 Page(s): e105101
    01/01/2014 Authors: Sutliff RL; Walp ER; Kim YH; Walker LA; El-Ali AM; Ma J; Bonsall R; Ramosevac S; Eaton DC; Verlander JW
  • Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation.
    Am J Physiol Renal Physiol Volume: 305 Page(s): F427 - F438
    08/15/2013 Authors: Wall SM; Weinstein AM
  • Nitric oxide reduces Cl absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.
    Am J Physiol Renal Physiol Volume: 304 Page(s): F1390 - F1397
    06/01/2013 Authors: Pech V; Thumova M; Dikalov SI; Hummler E; Rossier BC; Harrison DG; Wall SM
  • Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
    Am J Physiol Renal Physiol Volume: 303 Page(s): F812 - F820
    09/15/2012 Authors: Thumova M; Pech V; Froehlich O; Agazatian D; Wang X; Verlander JW; Kim YH; Wall SM
  • ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.
    Am J Physiol Renal Physiol Volume: 303 Page(s): F45 - F55
    07/01/2012 Authors: Pech V; Thumova M; Kim YH; Agazatian D; Hummler E; Rossier BC; Weinstein AM; Nanami M; Wall SM
  • Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.
    Am J Physiol Renal Physiol Volume: 301 Page(s): F1314 - F1325
    12/01/2011 Authors: Verlander JW; Hong S; Pech V; Bailey JL; Agazatian D; Matthews SW; Coffman TM; Le T; Inagami T; Whitehill FM
  • Nitric oxide reduces renal pendrin abundance
    Volume: 25
    04/01/2011 Authors: Thumova M; Pech V; Kim YH; Wall SM
  • Pendrin modulates ENaC function by changing luminal HCO3-.
    J Am Soc Nephrol Volume: 21 Page(s): 1928 - 1941
    11/01/2010 Authors: Pech V; Pham TD; Hong S; Weinstein AM; Spencer KB; Duke BJ; Walp E; Kim YH; Sutliff RL; Bao H-F
  • The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.
    J Clin Invest Volume: 120 Page(s): 1627 - 1635
    05/01/2010 Authors: Leviel F; Hbner CA; Houillier P; Morla L; El Moghrabi S; Brideau G; Hassan H; Parker MD; Kurth I; Kougioumtzes A
  • Pendrin regulates ENaC abundance and function by modulating luminal HCO3-concentration
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Pech V; Pham TD; Hong SM; Spencer KB; Duke BJ; Walp E; Kim YH; Sutliff RL; Eaton DC; Wall SM
  • Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland.
    J Physiol Volume: 588 Page(s): 713 - 724
    02/15/2010 Authors: Cataln MA; Nakamoto T; Gonzalez-Begne M; Camden JM; Wall SM; Clarke LL; Melvin JE
  • Pendrin and sodium channels: relevance to hypertension.
    J Nephrol Volume: 23 Suppl 16 Page(s): S118 - S123
    01/01/2010 Authors: Wall SM; Pech V
  • Role of pendrin in iodide balance: going with the flow.
    Am J Physiol Renal Physiol Volume: 297 Page(s): F1069 - F1079
    10/01/2009 Authors: Kim YH; Pham TD; Zheng W; Hong S; Baylis C; Pech V; Beierwaltes WH; Farley DB; Braverman LE; Verlander JW
  • Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.
    J Am Soc Nephrol Volume: 20 Page(s): 2018 - 2024
    09/01/2009 Authors: Wang Y; Klein JD; Blount MA; Martin CF; Kent KJ; Pech V; Wall SM; Sands JM
  • Pendrin gene ablation enhances vascular contractility
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Sutliff RL; Walp ER; Bonsall R; Ramosevac S; Eaton DC; Kim YH; Pham TD; Wall SM
  • Pendrin gene ablation enhances vascular contractility
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Sutliff RL; Walp ER; Bonsall R; Ramosevac S; Eaton DC; Kim YH; Pham TD; Wall SM
  • Salt sensitivity of blood pressure in NKCC1-deficient mice.
    Am J Physiol Renal Physiol Volume: 295 Page(s): F1230 - F1238
    10/01/2008 Authors: Kim SM; Eisner C; Faulhaber-Walter R; Mizel D; Wall SM; Briggs JP; Schnermann J
  • Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
    Am J Pathol Volume: 173 Page(s): 915 - 926
    10/01/2008 Authors: Gongora MC; Lob HE; Landmesser U; Guzik TJ; Martin WD; Ozumi K; Wall SM; Wilson DS; Murthy N; Gravanis M
  • The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct.
    J Physiol Volume: 586 Page(s): 3813 - 3824
    08/15/2008 Authors: Shcheynikov N; Yang D; Wang Y; Zeng W; Karniski LP; So I; Wall SM; Muallem S
  • Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct.
    Am J Physiol Renal Physiol Volume: 295 Page(s): F192 - F201
    07/01/2008 Authors: Chou C-L; Yu M-J; Kassai EM; Morris RG; Hoffert JD; Wall SM; Knepper MA
  • Role of NBCe1 and AE2 in secretory ameloblasts.
    J Dent Res Volume: 87 Page(s): 391 - 395
    04/01/2008 Authors: Paine ML; Snead ML; Wang HJ; Abuladze N; Pushkin A; Liu W; Kao LY; Wall SM; Kim Y-H; Kurtz I
  • Impaired autoregulation and TGF responses in NKCC1-deficient mice
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Oppermann M; Lorenz J; Wall S; Schnermann J
  • Angiotensin II activates H+-ATPase in type A intercalated cells.
    J Am Soc Nephrol Volume: 19 Page(s): 84 - 91
    01/01/2008 Authors: Pech V; Zheng W; Pham TD; Verlander JW; Wall SM
  • The interaction of pendrin and the epithelial sodium channel in blood pressure regulation.
    Curr Opin Nephrol Hypertens Volume: 17 Page(s): 18 - 24
    01/01/2008 Authors: Wall SM; Pech V
  • Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice.
    Am J Physiol Renal Physiol Volume: 293 Page(s): F1314 - F1324
    10/01/2007 Authors: Kim YH; Pech V; Spencer KB; Beierwaltes WH; Everett LA; Green ED; Shin W; Verlander JW; Sutliff RL; Wall SM
  • Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.
    Am J Physiol Heart Circ Physiol Volume: 292 Page(s): H2100 - H2105
    05/01/2007 Authors: Garg P; Martin CF; Elms SC; Gordon FJ; Wall SM; Garland CJ; Sutliff RL; O'Neill WC
  • Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
    Am J Physiol Renal Physiol Volume: 292 Page(s): F1314 - F1321
    05/01/2007 Authors: Nakaya K; Harbidge DG; Wangemann P; Schultz BD; Green ED; Wall SM; Marcus DC
  • Expression of AE2 and NBC1 in secretory ameloblasts
    Volume: 21 Page(s): A1284 - A1284
    04/01/2007 Authors: Paine M; Wang H; Abuladze N; Liu W; Wall SM; Kim Y-H; Kurtz I
  • Telemetrie blood pressure studies in NKCC1-deficient mice
    Volume: 21 Page(s): A503 - A503
    04/01/2007 Authors: Kim SM; Huang Y; Faulliaber-Walter R; Mizel D; Wall SM; Briggs JP; Schuermann J
  • Pendrin, encoded by Slc26 alpha 4, modulates ENaC expression and function
    Volume: 21 Page(s): A902 - A902
    04/01/2007 Authors: Kim Y-H; Pech V; Spencer KB; Beierwaltes WH; Everett LA; Green ED; Shin W; Sutliff RL; Wall SM
  • Role of NKCC1 in vasopressin-induced cell swelling in renal collecting duct cell
    Volume: 21 Page(s): A964 - A964
    04/01/2007 Authors: Chou CL; Morris RG; Yu MJ; Wall SM; Knepper MA
  • Angiotensin II activates H+-ATPase in type A intercalated cells in mouse cortical collecting duct
    Volume: 21 Page(s): A1329 - A1330
    04/01/2007 Authors: Pech V; Zheng W; Pham TD; Verlander JW; Wall SM
  • Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.
    Am J Physiol Renal Physiol Volume: 292 Page(s): F914 - F920
    03/01/2007 Authors: Pech V; Kim YH; Weinstein AM; Everett LA; Pham TD; Wall SM
  • Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney.
    Am J Physiol Renal Physiol Volume: 292 Page(s): F456 - F466
    01/01/2007 Authors: Zheng W; Verlander JW; Lynch IJ; Cash M; Shao J; Stow LR; Cain BD; Weiner ID; Wall SM; Wingo CS
  • Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.
    BMC Med Volume: 4 Page(s): 37
    12/22/2006 Authors: Jabba SV; Oelke A; Singh R; Maganti RJ; Fleming S; Wall SM; Everett LA; Green ED; Wangemann P
  • Dietary Cl(-) restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells.
    Am J Physiol Renal Physiol Volume: 291 Page(s): F833 - F839
    10/01/2006 Authors: Verlander JW; Kim YH; Shin W; Pham TD; Hassell KA; Beierwaltes WH; Green ED; Everett L; Matthews SW; Wall SM
  • Angiotensin II increases chloride absorption in the cortical collecting duct in mice by a pendrin-dependent mechanism
    Volume: 20 Page(s): A1225 - A1225
    03/07/2006 Authors: Pech V; Zheng WC; Pham TD; Verlander JW; Wall SM
  • Pendrin is upregulated with loop diuretics and is critical to the maintenance of fluid and electrolyte balance.
    Volume: 20 Page(s): A1223 - A1223
    03/07/2006 Authors: Kim YH; Wall SM; Pham DT; Pech V
  • Hypotension in NKCC1 null mice: role of the kidneys.
    Am J Physiol Renal Physiol Volume: 290 Page(s): F409 - F416
    02/01/2006 Authors: Wall SM; Knepper MA; Hassell KA; Fischer MP; Shodeinde A; Shin W; Pham TD; Meyer JW; Lorenz JN; Beierwaltes WH
  • The renal physiology of pendrin (SLC26A4) and its role in hypertension.
    Novartis Found Symp Volume: 273 Page(s): 231 - 239
    01/01/2006 Authors: Wall SM
  • Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice.
    Am J Physiol Renal Physiol Volume: 289 Page(s): F1262 - F1272
    12/01/2005 Authors: Kim Y-H; Verlander JW; Matthews SW; Kurtz I; Shin W; Weiner ID; Everett LA; Green ED; Nielsen S; Wall SM
  • Vasopressin increases urea permeability in the initial IMCD from diabetic rats.
    Am J Physiol Renal Physiol Volume: 289 Page(s): F531 - F535
    09/01/2005 Authors: Pech V; Klein JD; Kozlowski SD; Wall SM; Sands JM
  • Recent advances in our understanding of intercalated cells.
    Curr Opin Nephrol Hypertens Volume: 14 Page(s): 480 - 484
    09/01/2005 Authors: Wall SM
  • NKCC1 null mice have reduced blood pressure and are hypochloremic
    Volume: 19 Page(s): A1590 - A1590
    03/07/2005 Authors: Wall SM; Knepper MA; Hassell KA; Fischer M; Shin WK; Lorenz J; Shull G; Kim YH
  • Vasopressin increases urea permeability in initial IMCDs from diabetic rats
    Volume: 19 Page(s): A587 - A587
    03/04/2005 Authors: Pech V; Kozlowski SD; Klein JD; Wall SM; Sands JM
  • NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation.
    Hypertension Volume: 44 Page(s): 982 - 987
    12/01/2004 Authors: Wall SM; Kim YH; Stanley L; Glapion DM; Everett LA; Green ED; Verlander JW
  • AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading.
    Am J Physiol Renal Physiol Volume: 286 Page(s): F1163 - F1170
    06/01/2004 Authors: Frische S; Zolotarev AS; Kim Y-H; Praetorius J; Alper S; Nielsen S; Wall SM
  • Mechanisms of NH4+ and NH3 transport during hypokalemia.
    Acta Physiol Scand Volume: 179 Page(s): 325 - 330
    12/01/2003 Authors: Wall SM
  • Altered expression of renal acid-base transporters in rats with lithium-induced NDI.
    Am J Physiol Renal Physiol Volume: 285 Page(s): F1244 - F1257
    12/01/2003 Authors: Kim Y-H; Kwon T-H; Christensen BM; Nielsen J; Wall SM; Madsen KM; Frkiaer J; Nielsen S
  • Deoxycorticosterone upregulates pds (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension
    Volume: 14 Page(s): 312A - 312A
    11/01/2003 Authors: Wall SM; Hassell KA; Royaux IE; Glapion DM; Wang ME; Everett LA; Green ED; Verlander JW
  • AE2 isoforms in rat kidney: Immunohistochemical localization and regulation in response to chronic NH4Cl loading
    Volume: 14 Page(s): 303A - 303A
    11/01/2003 Authors: Frische S; Zolotarev AS; Praetorius J; Kim YL; Alper S; Nielsen S; Wall SM
  • ANG II reduces net acid secretion in rat outer medullary collecting duct.
    Am J Physiol Renal Physiol Volume: 285 Page(s): F930 - F937
    11/01/2003 Authors: Wall SM; Fischer MP; Glapion DM; De La Calzada M
  • Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension.
    Hypertension Volume: 42 Page(s): 356 - 362
    09/01/2003 Authors: Verlander JW; Hassell KA; Royaux IE; Glapion DM; Wang M-E; Everett LA; Green ED; Wall SM
  • Localization of pendrin in mouse kidney.
    Am J Physiol Renal Physiol Volume: 284 Page(s): F229 - F241
    01/01/2003 Authors: Wall SM; Hassell KA; Royaux IE; Green ED; Chang JY; Shipley GL; Verlander JW
  • Contribution of the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) to transepithelial transport of H(+), NH(4)(+), K(+), and Na(+) in rat outer medullary collecting duct.
    J Am Soc Nephrol Volume: 13 Page(s): 827 - 835
    04/01/2002 Authors: Wall SM; Fischer MP
  • In rat inner medullary collecting duct, NH uptake by the Na,K-ATPase is increased during hypokalemia.
    Am J Physiol Renal Physiol Volume: 282 Page(s): F91 - 102
    01/01/2002 Authors: Wall SM; Fischer MP; Kim G-H; Nguyen B-M; Hassell KA
  • Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD.
    Am J Physiol Renal Physiol Volume: 280 Page(s): F913 - F921
    05/01/2001 Authors: Wall SM; Fischer MP; Mehta P; Hassell KA; Park SJ
  • Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion.
    Proc Natl Acad Sci U S A Volume: 98 Page(s): 4221 - 4226
    03/27/2001 Authors: Royaux IE; Wall SM; Karniski LP; Everett LA; Suzuki K; Knepper MA; Green ED
  • Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion
    FASEB JOURNAL Volume: 15 Page(s): A502 - A502
    03/07/2001 Authors: Royaux IE; Karniski LP; Everett LA; Knepper MA; Green ED; Wall SM
  • Impact of K(+) homeostasis on net acid secretion in rat terminal inner medullary collecting duct: role of the Na,K-ATPase.
    Am J Kidney Dis Volume: 36 Page(s): 1079 - 1088
    11/01/2000 Authors: Wall SM
  • In rat tIMCD, NH4+ uptake by Na+-K+-ATPase is critical to net acid secretion during chronic hypokalemia.
    Am J Physiol Volume: 277 Page(s): F866 - F874
    12/01/1999 Authors: Wall SM; Davis BS; Hassell KA; Mehta P; Park SJ
  • Contrasting functional and regulatory profiles of the renal H+,K+-ATPases.
    Semin Nephrol Volume: 19 Page(s): 399 - 404
    09/01/1999 Authors: Codina J; Wall SM; DuBose TD
  • Dietary K+restriction upregulates total and Sch-28080-sensitive bicarbonate absorption in rat tIMCD.
    Am J Physiol Renal Physiol Volume: 275 Page(s): F543 - F549
    10/01/1998 Authors: Wall SM; Mehta P; DuBose TD
  • The Na-K-2Cl cotransporter mediates net acid secretion in the rat outer medullary collecting duct, inner stripe (OMCDis).
    Volume: 46 Page(s): 63A - 63A
    01/01/1998 Authors: Wall SM
  • Ouabain reduces net acid secretion and increases pHi by inhibiting NH4+ uptake on rat tIMCD Na(+)-K(+)-ATPase.
    Am J Physiol Volume: 273 Page(s): F857 - F868
    12/01/1997 Authors: Wall SM
  • The Na-K-2Cl cotransporter mediates net acid secretion in the rat outer medullary collecting duct, inner stripe (OMCDis).
    Volume: 8 Page(s): A0056 - A0056
    09/01/1997 Authors: Wall SM
  • Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cells.
    Am J Physiol Volume: 273 Page(s): C558 - C571
    08/01/1997 Authors: Guntupalli J; Onuigbo M; Wall S; Alpern RJ; DuBose TD
  • Effective clearance of methotrexate using high-flux hemodialysis membranes.
    Am J Kidney Dis Volume: 28 Page(s): 846 - 854
    12/01/1996 Authors: Wall SM; Johansen MJ; Molony DA; DuBose TD; Jaffe N; Madden T
  • H(+)-K(+)-ATPase mediates net acid secretion in rat terminal inner medullary collecting duct.
    Am J Physiol Volume: 271 Page(s): F1037 - F1044
    11/01/1996 Authors: Wall SM; Truong AV; DuBose TD
  • NH+4 augments net acid secretion by a ouabain-sensitive mechanism in isolated perfused inner medullary collecting ducts.
    Am J Physiol Volume: 270 Page(s): F432 - F439
    03/01/1996 Authors: Wall SM
  • Ammonium transport and the role of the Na,K-ATPase.
    Miner Electrolyte Metab Volume: 22 Page(s): 311 - 317
    01/01/1996 Authors: Wall SM
  • Heterogeneity of NH+4 transport in mouse inner medullary collecting duct cells.
    Am J Physiol Volume: 269 Page(s): F536 - F544
    10/01/1995 Authors: Wall SM; Trinh HN; Woodward KE
  • ADAPTATION TO LOW POTASSIUM IN-VITRO ENHANCES H+,K(+)ATPASE MEDIATED PH(I) REGULATION IN THE OUTER MEDULLARY COLLECTING DUCT CELL-LINE
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 6 Page(s): 313 - 313
    09/01/1995 Authors: ONUIGBO M; GUNTUPALLI J; WALL S; DUBOSE TD
  • NH+4 transport mediated by Na(+)-K(+)-ATPase in rat inner medullary collecting duct.
    Am J Physiol Volume: 267 Page(s): F660 - F670
    10/01/1994 Authors: Wall SM; Koger LM
  • EFFECT OF NA-K-ATPASE MEDIATED NH4+ TRANSPORT ON NET ACID-SECRETION IN ISOLATED-PERFUSED RAT INNER MEDULLARY COLLECTING DUCT (IMCD)
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 264 - 264
    09/01/1994 Authors: WALL SM
  • Mechanism of NH4+ transport in the rat collecting duct.
    Contrib Nephrol Volume: 110 Page(s): 75 - 80
    01/01/1994 Authors: Wall SM
  • Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD.
    Am J Physiol Volume: 262 Page(s): F989 - F998
    06/01/1992 Authors: Wall SM; Han JS; Chou CL; Knepper MA
  • Ammonium and bicarbonate transport in rat outer medullary collecting ducts.
    Am J Physiol Volume: 262 Page(s): F1 - F7
    01/01/1992 Authors: Flessner MF; Wall SM; Knepper MA
  • Regulation of collecting duct water permeability independent of cAMP-mediated AVP response.
    Am J Physiol Volume: 261 Page(s): F554 - F566
    09/01/1991 Authors: Lankford SP; Chou CL; Terada Y; Wall SM; Wade JB; Knepper MA
  • Ammonium transport in the kidney: new physiological concepts and their clinical implications.
    J Am Soc Nephrol Volume: 1 Page(s): 1193 - 1203
    05/01/1991 Authors: DuBose TD; Good DW; Hamm LL; Wall SM
  • Distribution of luminal carbonic anhydrase activity along rat inner medullary collecting duct.
    Am J Physiol Volume: 260 Page(s): F738 - F748
    05/01/1991 Authors: Wall SM; Flessner MF; Knepper MA
  • Permeabilities of rat collecting duct segments to NH3 and NH4+.
    Am J Physiol Volume: 260 Page(s): F264 - F272
    02/01/1991 Authors: Flessner MF; Wall SM; Knepper MA
  • ENDOGENOUS LUMINAL CARBONIC-ANHYDRASE IS PRESENT IN THE INITIAL SUBSEGMENT OF THE RAT INNER MEDULLARY COLLECTING DUCT
    CLINICAL RESEARCH Volume: 38 Page(s): A314 - A314
    04/01/1990 Authors: WALL SM; FLESSNER MF; KNEPPER MA
  • AMMONIUM AND BICARBONATE TRANSPORT IN RAT OUTER MEDULLARY COLLECTING DUCT
    CLINICAL RESEARCH Volume: 38 Page(s): A274 - A274
    04/01/1990 Authors: FLESSNER MF; WALL SM; KNEPPER MA
  • Acid-base transport in the inner medullary collecting duct.
    Semin Nephrol Volume: 10 Page(s): 148 - 158
    03/01/1990 Authors: Wall SM; Knepper MA
  • NH3 AND NH4 PERMEABILITIES OF RENAL MEDULLARY TUBULE SEGMENTS
    KIDNEY INTERNATIONAL Volume: 37 Page(s): 536 - 536
    01/01/1990 Authors: FLESSNER MF; WALL SM; KNEPPER MA
  • Net acid transport by isolated perfused inner medullary collecting ducts.
    Am J Physiol Volume: 258 Page(s): F75 - F84
    01/01/1990 Authors: Wall SM; Sands JM; Flessner MF; Nonoguchi H; Spring KR; Knepper MA
  • Modulation of Na+-H+ exchange activity by intracellular Na+, H+, and Li+ in IMCD cells.
    Am J Physiol Volume: 255 Page(s): F331 - F339
    08/01/1988 Authors: Wall SM; Kraut JA; Muallem S
  • Detection of a Na+-H+ antiporter in cultured rat renal papillary collecting duct cells.
    Am J Physiol Volume: 253 Page(s): F889 - F895
    11/01/1987 Authors: Wall SM; Muallem S; Kraut JA
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