Randy Hall PhD

Department of Pharmacology & Chemical Biology
Professor

Emory University School of Medicine
Department of Pharmacology
1510 Clifton Rd.

Overview

Research Area:

Mechanisms of signal transduction by neurotransmitter and hormone receptors

Research Interests:

Our research is focused on the mechanisms of signal transduction by neurotransmitter and hormone receptors. In particular, we study receptor interactions with cytoplasmic proteins that may act as mediators of receptor signaling and/or as scaffold proteins involved in the regulation of receptor trafficking and localization. We also study receptor interactions with other receptors, which can strongly regulate receptor trafficking and may underlie many unexplained examples of cross-talk between different neurotransmitter systems. Understanding the mechanisms of signal transduction and trafficking of neurotransmitter and hormone receptors is of paramount clinical importance, since such receptors are extremely common targets for therapeutic

Academic Appointment

Professor, Emory University School of Medicine

Education

Degrees

Postdoctoral Fellow from Howard Hughes Medical Institute, Duke Medical Center
Postdoctoral Fellow from Vollum Institute, Oregon Health Sciences University
PhD from University of California at Irvine

Research

Publications

GPR37L1 controls maturation and organization of cortical astrocytes during development.
Glia Volume: 71 Page(s): 1921 - 1946
08/01/2023 Authors: Nguyen TT; Camp CR; Doan JK; Traynelis SF; Sloan SA; Hall RA
Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity.
J Biol Chem Volume: 298 Page(s): 102685
12/01/2022 Authors: Lala T; Doan JK; Takatsu H; Hartzell HC; Shin H-W; Hall RA
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology.
Physiol Rev Volume: 102 Page(s): 1587 - 1624
10/01/2022 Authors: Lala T; Hall RA
Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development.
Exp Neurol Volume: 351 Page(s): 113994
05/01/2022 Authors: Shiu FH; Wong JC; Yamamoto T; Lala T; Purcell RH; Owino S; Zhu D; Van Meir EG; Hall RA; Escayg A
GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.
Exp Neurol Volume: 342 Page(s): 113719
08/01/2021 Authors: Owino S; Giddens MM; Jiang JG; Nguyen TT; Shiu FH; Lala T; Gearing M; McCrary MR; Gu X; Wei L
Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1.
J Proteome Res Volume: 19 Page(s): 744 - 755
02/07/2020 Authors: Nguyen TT; Dammer EB; Owino SA; Giddens MM; Madaras NS; Duong DM; Seyfried NT; Hall RA
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Ann N Y Acad Sci Volume: 1456 Page(s): 5 - 25
11/01/2019 Authors: Morgan RK; Anderson GR; Ara D; Aust G; Balenga N; Boucard A; Bridges JP; Engel FB; Formstone CJ; Glitsch MD
Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice.
FASEB J Volume: 33 Page(s): 10680 - 10691
10/01/2019 Authors: McCrary MR; Jiang MQ; Giddens MM; Zhang JY; Owino S; Wei ZZ; Zhong W; Gu X; Xin H; Hall RA
Ultrastructural localization of DREADDs in monkeys.
Eur J Neurosci Volume: 50 Page(s): 2801 - 2813
09/01/2019 Authors: Galvan A; Raper J; Hu X; Par J-F; Bonaventura J; Richie CT; Michaelides M; Mueller SAL; Roseboom PH; Oler JA
Adhesion G Protein-Coupled Receptors as Drug Targets.
Annu Rev Pharmacol Toxicol Volume: 58 Page(s): 429 - 449
01/06/2018 Authors: Purcell RH; Hall RA
A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity.
Hum Mutat Volume: 38 Page(s): 1751 - 1760
12/01/2017 Authors: Purcell RH; Toro C; Gahl WA; Hall RA
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Neurobiol Dis Volume: 106 Page(s): 181 - 190
10/01/2017 Authors: Giddens MM; Wong JC; Schroeder JP; Farrow EG; Smith BM; Owino S; Soden SE; Meyer RC; Saunders C; LePichon JB
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
Sci Rep Volume: 7 Page(s): 11771
09/18/2017 Authors: Wang Y; Hall RA; Lee M; Kamgar-Parsi A; Bi X; Baudry M
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
Neuroscience Volume: 358 Page(s): 49 - 57
09/01/2017 Authors: Smith BM; Giddens MM; Neil J; Owino S; Nguyen TT; Duong D; Li F; Hall RA
Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.
Neuroscience Volume: 353 Page(s): 58 - 75
06/14/2017 Authors: Ritter-Makinson SL; Paquet M; Bogenpohl JW; Rodin RE; Chris Yun C; Weinman EJ; Smith Y; Hall RA
Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling.
J Biol Chem Volume: 292 Page(s): 9711 - 9720
06/09/2017 Authors: Kishore A; Hall RA
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.
Nat Neurosci Volume: 19 Page(s): 443 - 453
03/01/2016 Authors: Knafo S; Snchez-Puelles C; Palomer E; Delgado I; Draffin JE; Mingo J; Wahle T; Kaleka K; Mou L; Pereda-Perez I
Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1).
J Biol Chem Volume: 291 Page(s): 3385 - 3394
02/12/2016 Authors: Kishore A; Purcell RH; Nassiri-Toosi Z; Hall RA
Chronic loss of noradrenergic tone produces -arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.
Addict Biol Volume: 21 Page(s): 35 - 48
01/01/2016 Authors: Gaval-Cruz M; Goertz RB; Puttick DJ; Bowles DE; Meyer RC; Hall RA; Ko D; Paladini CA; Weinshenker D
Versatile Signaling Activity of Adhesion GPCRs.
Handb Exp Pharmacol Volume: 234 Page(s): 127 - 146
01/01/2016 Authors: Kishore A; Hall RA
BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
J Clin Invest Volume: 125 Page(s): 1497 - 1508
04/01/2015 Authors: Zhu D; Li C; Swanson AM; Villalba RM; Guo J; Zhang Z; Matheny S; Murakami T; Stephenson JR; Daniel S
D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold.
Protein Sci Volume: 24 Page(s): 105 - 116
01/01/2015 Authors: Sarma GN; Moody IS; Ilouz R; Phan RH; Sankaran B; Hall RA; Taylor SS
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Pharmacol Rev Volume: 67 Page(s): 338 - 367
01/01/2015 Authors: Hamann J; Aust G; Ara D; Engel FB; Formstone C; Fredriksson R; Hall RA; Harty BL; Kirchhoff C; Knapp B
Studying protein-protein interactions via blot overlay/far western blot.
Methods Mol Biol Volume: 1278 Page(s): 371 - 379
01/01/2015 Authors: Hall RA
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.
Ann N Y Acad Sci Volume: 1333 Page(s): 43 - 64
12/01/2014 Authors: Liebscher I; Ackley B; Ara D; Ariestanti DM; Aust G; Bae B-I; Bista BR; Bridges JP; Duman JG; Engel FB
The protective role of prosaposin and its receptors in the nervous system.
Brain Res Volume: 1585 Page(s): 1 - 12
10/17/2014 Authors: Meyer RC; Giddens MM; Coleman BM; Hall RA
Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins.
Physiol Rep Volume: 2
05/01/2014 Authors: Lee HJ; Kwon MH; Lee S; Hall RA; Yun CC; Choi I
The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond.
Trends Pharmacol Sci Volume: 35 Page(s): 208 - 215
04/01/2014 Authors: Stephenson JR; Purcell RH; Hall RA
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1.
J Biol Chem Volume: 289 Page(s): 1649 - 1661
01/17/2014 Authors: Jiang JY; Nagaraju M; Meyer RC; Zhang L; Hamelberg D; Hall RA; Brown EM; Conn PJ; Yang JJ
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Mol Biol Cell Volume: 24 Page(s): 2849 - 2860
09/01/2013 Authors: Monteiro AC; Sumagin R; Rankin CR; Leoni G; Mina MJ; Reiter DM; Stehle T; Dermody TS; Schaefer SA; Hall RA
Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.
J Biol Chem Volume: 288 Page(s): 22248 - 22256
08/02/2013 Authors: Stephenson JR; Paavola KJ; Schaefer SA; Kaur B; Van Meir EG; Hall RA
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 9529 - 9534
06/04/2013 Authors: Meyer RC; Giddens MM; Schaefer SA; Hall RA
Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.
J Biol Chem Volume: 288 Page(s): 15023 - 15034
05/24/2013 Authors: Dunn HA; Walther C; Godin CM; Hall RA; Ferguson SSG
JAM-A -mediated regulation of epithelial barrier function is dependent on a complex with ZO-2, Afadin and PDZ-GEF1 that modulates Rap2c activity
Volume: 27
04/01/2013 Authors: Monteiro A; Sumagin R; Rankin CR; Leoni G; Reiter D; Stehle T; Dermody T; Hall RA; Nusrat A; Parkos CA
SAP97 promotes the stability of Nax channels at the plasma membrane.
FEBS Lett Volume: 586 Page(s): 3805 - 3812
11/02/2012 Authors: Matsumoto M; Fujikawa A; Suzuki R; Shimizu H; Kuboyama K; Hiyama TY; Hall RA; Noda M
Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation.
Mol Pharmacol Volume: 82 Page(s): 777 - 783
11/01/2012 Authors: Paavola KJ; Hall RA
Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactions.
Mol Cell Volume: 46 Page(s): 226 - 237
04/27/2012 Authors: Chen Y; Sheng R; Kllberg M; Silkov A; Tun MP; Bhardwaj N; Kurilova S; Hall RA; Honig B; Lu H
Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum.
J Comp Neurol Volume: 520 Page(s): 570 - 589
02/15/2012 Authors: Bogenpohl JW; Ritter SL; Hall RA; Smith Y
A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism.
PLoS One Volume: 7 Page(s): e34764
01/01/2012 Authors: Courbebaisse M; Leroy C; Bakouh N; Salan C; Beck L; Grandchamp B; Planelles G; Hall RA; Friedlander G; Pri D
Protein kinase C promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1).
J Biol Chem Volume: 286 Page(s): 43559 - 43568
12/16/2011 Authors: O'Neill AK; Gallegos LL; Justilien V; Garcia EL; Leitges M; Fields AP; Hall RA; Newton AC
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 cells: identification of PACAP 6-38 as a CART receptor antagonist.
Neuropeptides Volume: 45 Page(s): 351 - 358
10/01/2011 Authors: Lin Y; Hall RA; Kuhar MJ
The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.
J Biol Chem Volume: 286 Page(s): 28914 - 28921
08/19/2011 Authors: Paavola KJ; Stephenson JR; Ritter SL; Alter SP; Hall RA
The GPR56 N-Terminus Controls Receptor Signaling Activity
Volume: 25
04/01/2011 Authors: Paavola KJ; Stephenson JR; Hall RA
Regulation and Signaling of the Orphan GPCR Brain Angiogenesis Inhibitor-1
Volume: 25
04/01/2011 Authors: Stephenson JR; Paavola KJ; Hall RA
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Gastroenterology Volume: 140 Page(s): 924 - 934
03/01/2011 Authors: Lee S-J; Ritter SL; Zhang H; Shim H; Hall RA; Yun CC
Autonomic modulation of olfactory signaling.
Sci Signal Volume: 4 Page(s): pe1
01/11/2011 Authors: Hall RA
GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2.
Neurosci Lett Volume: 487 Page(s): 3 - 7
01/03/2011 Authors: Ritter SL; Asay MJ; Paquet M; Paavola KJ; Reiff RE; Yun CC; Hall RA
Detection and characterization of receptor interactions with PDZ domains.
Methods Mol Biol Volume: 756 Page(s): 345 - 356
01/01/2011 Authors: Ritter SL; Hall RA
Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.
Cell Microbiol Volume: 12 Page(s): 1718 - 1731
12/01/2010 Authors: Martinez E; Schroeder GN; Berger CN; Lee SF; Robinson KS; Badea L; Simpson N; Hall RA; Hartland EL; Crepin VF
Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.
J Biol Chem Volume: 285 Page(s): 33463 - 33474
10/22/2010 Authors: Jiang Y; Huang Y; Wong H-C; Zhou Y; Wang X; Yang J; Hall RA; Brown EM; Yang JJ
Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.
J Biol Chem Volume: 285 Page(s): 26976 - 26986
08/27/2010 Authors: Wang B; Ardura JA; Romero G; Yang Y; Hall RA; Friedman PA
Fine-tuning of GPCR activity by receptor-interacting proteins.
Nat Rev Mol Cell Biol Volume: 10 Page(s): 819 - 830
12/01/2009 Authors: Ritter SL; Hall RA
GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.
Biochemistry Volume: 48 Page(s): 10286 - 10297
11/03/2009 Authors: Dunham JH; Meyer RC; Garcia EL; Hall RA
Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo.
J Thromb Haemost Volume: 7 Page(s): 1886 - 1896
11/01/2009 Authors: Stalker TJ; Wu J; Morgans A; Traxler EA; Wang L; Chatterjee MS; Lee D; Quertermous T; Hall RA; Hammer DA
Take it to heart: talking drugs, supplements, and cardiovascular health with Bob Lefkowitz. Interview by Randy A. Hall.
Mol Interv Volume: 9 Page(s): 220 - 225
10/01/2009 Authors: Lefkowitz B
The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.
J Biol Chem Volume: 284 Page(s): 24653 - 24661
09/04/2009 Authors: Kunkel MT; Garcia EL; Kajimoto T; Hall RA; Newton AC
Enhancement of the surface expression of G protein-coupled receptors.
Trends Biotechnol Volume: 27 Page(s): 541 - 545
09/01/2009 Authors: Dunham JH; Hall RA
Olfactory receptor interactions with other receptors.
Ann N Y Acad Sci Volume: 1170 Page(s): 147 - 149
07/01/2009 Authors: Hall RA
Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.
Chem Biol Volume: 16 Page(s): 644 - 656
06/26/2009 Authors: Jang S-W; Liu X; Chan C-B; Weinshenker D; Hall RA; Xiao G; Ye K
Olfactory Receptor Interactions with Other Receptors
Volume: 1170 Page(s): 147 - 149
01/01/2009 Authors: Hall RA
Olfactory receptor trafficking to the plasma membrane.
Cell Mol Life Sci Volume: 65 Page(s): 2289 - 2295
08/01/2008 Authors: Bush CF; Hall RA
Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system.
Mol Cell Proteomics Volume: 7 Page(s): 1362 - 1377
07/01/2008 Authors: Gisler SM; Kittanakom S; Fuster D; Wong V; Bertic M; Radanovic T; Hall RA; Murer H; Biber J; Markovich D
Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonism.
Eur J Neurosci Volume: 27 Page(s): 1647 - 1658
04/01/2008 Authors: Raju DV; Ahern TH; Shah DJ; Wright TM; Standaert DG; Hall RA; Smith Y
A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium.
Cell Microbiol Volume: 10 Page(s): 499 - 513
02/01/2008 Authors: Lee SF; Kelly M; McAlister A; Luck SN; Garcia EL; Hall RA; Robins-Browne RM; Frankel G; Hartland EL
Specificity of olfactory receptor interactions with other G protein-coupled receptors.
J Biol Chem Volume: 282 Page(s): 19042 - 19051
06/29/2007 Authors: Bush CF; Jones SV; Lyle AN; Minneman KP; Ressler KJ; Hall RA
Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion.
J Neurosci Volume: 27 Page(s): 6249 - 6260
06/06/2007 Authors: Kuwajima M; Dehoff MH; Furuichi T; Worley PF; Hall RA; Smith Y
Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet.
Epilepsy Res Volume: 74 Page(s): 232 - 236
05/01/2007 Authors: Bough KJ; Paquet M; Par J-F; Hassel B; Smith Y; Hall RA; Dingledine R
GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function.
J Biol Chem Volume: 282 Page(s): 4162 - 4171
02/09/2007 Authors: Balasubramanian S; Fam SR; Hall RA
Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit.
J Neurosci Volume: 27 Page(s): 1374 - 1385
02/07/2007 Authors: Calin-Jageman I; Yu K; Hall RA; Mei L; Lee A
MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Cell Signal Volume: 19 Page(s): 261 - 268
02/01/2007 Authors: Zhang H; Wang D; Sun H; Hall RA; Yun CC
Design of a selective chemical probe for class I PDZ domains.
Bioorg Med Chem Lett Volume: 17 Page(s): 546 - 548
01/15/2007 Authors: Fujii N; Shelat A; Hall RA; Guy RK
Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in rats.
J Comp Neurol Volume: 499 Page(s): 231 - 243
11/10/2006 Authors: Raju DV; Shah DJ; Wright TM; Hall RA; Smith Y
The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.
J Biol Chem Volume: 281 Page(s): 29949 - 29961
10/06/2006 Authors: Paquet M; Asay MJ; Fam SR; Inuzuka H; Castleberry AM; Oller H; Smith Y; Yun CC; Traynelis SF; Hall RA
Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors.
J Pharmacol Exp Ther Volume: 318 Page(s): 974 - 981
09/01/2006 Authors: Prinster SC; Holmqvist TG; Hall RA
GABA(B) receptors in the centromedian/parafascicular thalamic nuclear complex: an ultrastructural analysis of GABA(B)R1 and GABA(B)R2 in the monkey thalamus.
J Comp Neurol Volume: 496 Page(s): 269 - 287
05/10/2006 Authors: Villalba RM; Raju DV; Hall RA; Smith Y
Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.
J Biol Chem Volume: 281 Page(s): 12414 - 12420
05/05/2006 Authors: Chen Z; Hague C; Hall RA; Minneman KP
Heterodimers of alpha1B and alpha1D-adrenergic receptors form a single functional entity
Volume: 20 Page(s): A253 - A254
03/06/2006 Authors: Hague C; Lee SE; Chen ZJ; Prinster SC; Hall RA; Minneman KP
Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brain.
J Comp Neurol Volume: 494 Page(s): 752 - 762
02/10/2006 Authors: Paquet M; Kuwajima M; Yun CC; Smith Y; Hall RA
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.
J Biol Chem Volume: 281 Page(s): 2820 - 2827
02/03/2006 Authors: He J; Bellini M; Inuzuka H; Xu J; Xiong Y; Yang X; Castleberry AM; Hall RA
Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity.
Mol Pharmacol Volume: 69 Page(s): 45 - 55
01/01/2006 Authors: Hague C; Lee SE; Chen Z; Prinster SC; Hall RA; Minneman KP
The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.
Annu Rev Physiol Volume: 68 Page(s): 491 - 505
01/01/2006 Authors: Weinman EJ; Hall RA; Friedman PA; Liu-Chen L-Y; Shenolikar S
Heterodimerization of g protein-coupled receptors: specificity and functional significance.
Pharmacol Rev Volume: 57 Page(s): 289 - 298
09/01/2005 Authors: Prinster SC; Hague C; Hall RA
Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors.
Neurosci Lett Volume: 384 Page(s): 198 - 202
08/12/2005 Authors: Lakatos A; Prinster S; Vicentic A; Hall RA; Kuhar MJ
LPA2 receptor mediates mitogenic signals in human colon cancer cells.
Am J Physiol Cell Physiol Volume: 289 Page(s): C2 - 11
07/01/2005 Authors: Yun CC; Sun H; Wang D; Rusovici R; Castleberry A; Hall RA; Shim H
P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2.
Proc Natl Acad Sci U S A Volume: 102 Page(s): 8042 - 8047
05/31/2005 Authors: Fam SR; Paquet M; Castleberry AM; Oller H; Lee CJ; Traynelis SF; Smith Y; Yun CC; Hall RA
Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors.
J Pharmacol Exp Ther Volume: 313 Page(s): 16 - 23
04/01/2005 Authors: Uberti MA; Hague C; Oller H; Minneman KP; Hall RA
Olfactory receptor localization and function: an emerging role for GPCR heterodimerization.
Mol Interv Volume: 4 Page(s): 321 - 322
12/01/2004 Authors: Hague C; Hall RA; Minneman KP
Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.
J Biol Chem Volume: 279 Page(s): 50190 - 50196
11/26/2004 Authors: He J; Bellini M; Xu J; Castleberry AM; Hall RA
Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins.
Am J Physiol Gastrointest Liver Physiol Volume: 287 Page(s): G1100 - G1107
11/01/2004 Authors: Wang L; Kolachala V; Walia B; Balasubramanian S; Hall RA; Merlin D; Sitaraman SV
Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor.
Proc Natl Acad Sci U S A Volume: 101 Page(s): 13672 - 13676
09/14/2004 Authors: Hague C; Uberti MA; Chen Z; Bush CF; Jones SV; Ressler KJ; Hall RA; Minneman KP
An electron microscope immunocytochemical study of GABA(B) R2 receptors in the monkey basal ganglia: a comparative analysis with GABA(B) R1 receptor distribution.
J Comp Neurol Volume: 476 Page(s): 65 - 79
08/09/2004 Authors: Charara A; Galvan A; Kuwajima M; Hall RA; Smith Y
Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus.
J Comp Neurol Volume: 474 Page(s): 589 - 602
07/05/2004 Authors: Kuwajima M; Hall RA; Aiba A; Smith Y
kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins.
J Biol Chem Volume: 279 Page(s): 25002 - 25009
06/11/2004 Authors: Huang P; Steplock D; Weinman EJ; Hall RA; Ding Z; Li J; Wang Y; Liu-Chen L-Y
Beta-adrenergic receptors and their interacting proteins.
Semin Cell Dev Biol Volume: 15 Page(s): 281 - 288
06/01/2004 Authors: Hall RA
Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking.
J Biol Chem Volume: 279 Page(s): 18840 - 18850
04/30/2004 Authors: Balasubramanian S; Teissre JA; Raju DV; Hall RA
Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.
J Biol Chem Volume: 279 Page(s): 15541 - 15549
04/09/2004 Authors: Hague C; Uberti MA; Chen Z; Hall RA; Minneman KP
Studying protein-protein interactions via blot overlay or Far Western blot.
Methods Mol Biol Volume: 261 Page(s): 167 - 174
01/01/2004 Authors: Hall RA
Subtype-specific dimerization of alpha 1-adrenoceptors: effects on receptor expression and pharmacological properties.
Mol Pharmacol Volume: 64 Page(s): 1379 - 1390
12/01/2003 Authors: Uberti MA; Hall RA; Minneman KP
Cell cycle-dependent phosphorylation of Disabled-2 by cdc2.
Oncogene Volume: 22 Page(s): 4524 - 4530
07/17/2003 Authors: He J; Xu J; Xu X-X; Hall RA
Heterodimerization of alpha 2A- and beta 1-adrenergic receptors.
J Biol Chem Volume: 278 Page(s): 10770 - 10777
03/21/2003 Authors: Xu J; He J; Castleberry AM; Balasubramanian S; Lau AG; Hall RA
Regulation of G protein-coupled receptor signaling by scaffold proteins.
Circ Res Volume: 91 Page(s): 672 - 680
10/18/2002 Authors: Hall RA; Lefkowitz RJ
Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization.
Biochem Biophys Res Commun Volume: 297 Page(s): 565 - 572
09/27/2002 Authors: He J; Xu J; Castleberry AM; Lau AG; Hall RA
Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2.
J Biol Chem Volume: 277 Page(s): 29268 - 29274
08/09/2002 Authors: McClatchy DB; Knudsen CR; Clark BF; Kahn RA; Hall RA; Levey AI
Interaction between metabotropic glutamate receptor 7 and alpha tubulin.
J Neurochem Volume: 80 Page(s): 980 - 988
03/01/2002 Authors: Saugstad JA; Yang S; Pohl J; Hall RA; Conn PJ
Identification of novel G protein-coupled receptor-interacting proteins.
Methods Enzymol Volume: 343 Page(s): 611 - 621
01/01/2002 Authors: Premont RT; Hall RA
Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase.
J Biol Chem Volume: 276 Page(s): 41559 - 41565
11/09/2001 Authors: He J; Lau AG; Yaffe MB; Hall RA
beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.
J Biol Chem Volume: 276 Page(s): 41310 - 41317
11/02/2001 Authors: Xu J; Paquet M; Lau AG; Wood JD; Ross CA; Hall RA
Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylation.
Biochemistry Volume: 40 Page(s): 8572 - 8580
07/24/2001 Authors: Lau AG; Hall RA
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
EMBO J Volume: 19 Page(s): 6778 - 6791
12/15/2000 Authors: Kanai F; Marignani PA; Sarbassova D; Yagi R; Hall RA; Donowitz M; Hisaminato A; Fujiwara T; Ito Y; Cantley LC
beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
J Biol Chem Volume: 275 Page(s): 38659 - 38666
12/08/2000 Authors: Hu LA; Tang Y; Miller WE; Cong M; Lau AG; Lefkowitz RJ; Hall RA
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
Mol Cell Biol Volume: 20 Page(s): 8352 - 8363
11/01/2000 Authors: Maudsley S; Zamah AM; Rahman N; Blitzer JT; Luttrell LM; Lefkowitz RJ; Hall RA
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
Proc Natl Acad Sci U S A Volume: 96 Page(s): 12559 - 12564
10/26/1999 Authors: Tang Y; Hu LA; Miller WE; Ringstad N; Hall RA; Pitcher JA; DeCamilli P; Lefkowitz RJ
G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
J Biol Chem Volume: 274 Page(s): 24328 - 24334
08/20/1999 Authors: Hall RA; Spurney RF; Premont RT; Rahman N; Blitzer JT; Pitcher JA; Lefkowitz RJ
Heptahelical receptor signaling: beyond the G protein paradigm.
J Cell Biol Volume: 145 Page(s): 927 - 932
05/31/1999 Authors: Hall RA; Premont RT; Lefkowitz RJ
Heparin modulates the single channel kinetics of reconstituted AMPA receptors from rat brain.
Synapse Volume: 31 Page(s): 203 - 209
03/01/1999 Authors: Sinnarajah S; Suppiramaniam V; Kumar KP; Hall RA; Bahr BA; Vodyanoy V
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
Proc Natl Acad Sci U S A Volume: 95 Page(s): 8496 - 8501
07/21/1998 Authors: Hall RA; Ostedgaard LS; Premont RT; Blitzer JT; Rahman N; Welsh MJ; Lefkowitz RJ
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
J Biol Chem Volume: 273 Page(s): 17749 - 17755
07/10/1998 Authors: Snow BE; Hall RA; Krumins AM; Brothers GM; Bouchard D; Brothers CA; Chung S; Mangion J; Gilman AG; Lefkowitz RJ
Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).
J Clin Invest Volume: 101 Page(s): 2199 - 2206
05/15/1998 Authors: Weinman EJ; Steplock D; Tate K; Hall RA; Spurney RF; Shenolikar S
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
J Biol Chem Volume: 273 Page(s): 12316 - 12324
05/15/1998 Authors: Pitcher JA; Hall RA; Daaka Y; Zhang J; Ferguson SS; Hester S; Miller S; Caron MG; Lefkowitz RJ; Barak LS
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Nature Volume: 392 Page(s): 626 - 630
04/09/1998 Authors: Hall RA; Premont RT; Chow CW; Blitzer JT; Pitcher JA; Claing A; Stoffel RH; Barak LS; Shenolikar S; Weinman EJ
Quantitation of AMPA receptor surface expression in cultured hippocampal neurons.
Neuroscience Volume: 78 Page(s): 361 - 371
05/01/1997 Authors: Hall RA; Soderling TR
Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons.
J Biol Chem Volume: 272 Page(s): 4135 - 4140
02/14/1997 Authors: Hall RA; Soderling TR
Surface expression of the AMPA receptor subunits GluR1, GluR2, and GluR4 in stably transfected baby hamster kidney cells.
J Neurochem Volume: 68 Page(s): 625 - 630
02/01/1997 Authors: Hall RA; Hansen A; Andersen PH; Soderling TR
Effects of heparin on the properties of solubilized and reconstituted rat brain AMPA receptors.
Neurosci Lett Volume: 217 Page(s): 179 - 183
10/18/1996 Authors: Hall RA; Vodyanoy V; Quan A; Sinnarajah S; Suppiramaniam V; Kessler M; Bahr BA
Distinct distributions of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits and a related 53,000 M(R) antigen (GR53) in brain tissue.
Neuroscience Volume: 74 Page(s): 707 - 721
10/01/1996 Authors: Bahr BA; Hoffman KB; Kessler M; Hennegriff M; Park GY; Yamamoto RS; Kawasaki BT; Vanderklish PW; Hall RA; Lynch G
Ultraviolet radiation, thiol reagents, and solubilization enhance AMPA receptor binding affinity via a common mechanism.
Neurochem Res Volume: 21 Page(s): 963 - 968
08/01/1996 Authors: Hall RA; Quan A; Kessler M; Lynch G
Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices.
Hippocampus Volume: 5 Page(s): 425 - 439
01/01/1995 Authors: Bahr BA; Kessler M; Rivera S; Vanderklish PW; Hall RA; Mutneja MS; Gall C; Hoffman KB
AMPA receptor development in rat telencephalon: [3H]AMPA binding and western blot studies.
J Neurochem Volume: 63 Page(s): 1658 - 1665
11/01/1994 Authors: Hall RA; Bahr BA
Kainate binding to the AMPA receptor in rat brain.
Neurochem Res Volume: 19 Page(s): 777 - 782
06/01/1994 Authors: Hall RA; Kessler M; Lynch G
Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus.
Neuroreport Volume: 5 Page(s): 389 - 392
01/12/1994 Authors: Larson J; Le TT; Hall RA; Lynch G
Cyclothiazide decreases [3H]AMPA binding to rat brain membranes: evidence that AMPA receptor desensitization increases agonist affinity.
Brain Res Volume: 628 Page(s): 345 - 348
11/19/1993 Authors: Hall RA; Kessler M; Quan A; Ambros-Ingerson J; Lynch G
Thiocyanate equally increases affinity for two DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor states.
Mol Pharmacol Volume: 43 Page(s): 459 - 464
03/01/1993 Authors: Hall RA; Massicotte G; Kessler M; Baudry M; Lynch G
Single channel recordings of reconstituted AMPA receptors reveal low and high conductance states.
Neurosci Lett Volume: 150 Page(s): 80 - 84
02/05/1993 Authors: Vodyanoy V; Bahr BA; Suppiramaniam V; Hall RA; Baudry M; Lynch G
Evidence that high- and low-affinity DL-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding sites reflect membrane-dependent states of a single receptor.
J Neurochem Volume: 59 Page(s): 1997 - 2004
12/01/1992 Authors: Hall RA; Kessler M; Lynch G
Functional reconstitution of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors from rat brain.
J Neurochem Volume: 59 Page(s): 1979 - 1982
11/01/1992 Authors: Bahr BA; Vodyanoy V; Hall RA; Suppiramaniam V; Kessler M; Sumikawa K; Lynch G
Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers.
Brain Res Volume: 589 Page(s): 320 - 326
09/04/1992 Authors: Bahr BA; Godshall AC; Hall RA; Lynch G
Lipoprotein subfraction composition in non-insulin-dependent diabetes treated by diet, sulphonylurea, and insulin.
Metabolism Volume: 38 Page(s): 850 - 857
09/01/1989 Authors: Billingham MS; Milles JJ; Bailey CJ; Hall RA
Apolipoprotein assays: methodological considerations and studies in non-insulin-dependent diabetes treated by diet, glibenclamide and insulin.
Scand J Clin Lab Invest Volume: 49 Page(s): 239 - 247
05/01/1989 Authors: Billingham MS; Milles JJ; Green A; Bailey CJ; Hall RA
Lipoprotein subfraction composition in non-obese newly diagnosed non-insulin dependent diabetes after treatment with diet and glibenclamide.
Diabetes Res Volume: 11 Page(s): 13 - 20
05/01/1989 Authors: Billingham MS; Milles JJ; Bailey CJ; Hall RA
High density lipoprotein cholesterol and apolipoprotein a-1 concentrations in non-insulin dependent diabetics treated by diet and chlorpropamide.
Diabete Metab Volume: 8 Page(s): 229 - 233
09/01/1982 Authors: Billingham MS; Leatherdale BA; Hall RA; Bailey CJ
Plasma high density lipoprotein cholesterol in streptozotocin diabetic and non-diabetic mice after prolonged administration of glibenclamide, chlorpropamide and metformin.
Diabete Metab Volume: 7 Page(s): 271 - 274
12/01/1981 Authors: Billingham MS; Hall RA; Simpson S; Bailey CJ
Lack of effect of glibenclamide, chlorpropamide and metformin on plasma cholesterol and HDL-cholesterol in non-diabetic rats.
Horm Metab Res Volume: 12 Page(s): 340 - 341
07/01/1980 Authors: Billingham MS; Hall RA; Simpson S; Bailey CJ

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