Michael Epstein PhD
- Department of Human Genetics
Professor
- (404) 712-8289
- mpepste@emory.edu
- Epstein Lab
- Emory Center for Computational and Quantitative Genetics
- Google Scholar
-
615 Michael Street
Suite 305L
Atlanta, GA 30322
Overview
My research focuses on statistical techniques for human gene mapping of complex traits. This work involves two synergistic components: a methodological component focused on developing novel statistical techniques for improved gene mapping and an applied component focused on using existing methods to map genes involved in diseases such as schizophrenia, epilepsy, and post-traumatic stress disorder.
I am also Director of the Center for Computational and Quantitative Genetics at Emory. The Center's focus is on development and application of quantitative tools for mapping genes involved in human traits.
Academic Appointment
- Professor, Department of Human Genetics, Emory University
- Adjunct Professor, Department of Biostatistics and Bioinformatics, Emory University
Education
Degrees
- PhD from University of Michigan
- M.S. from University of Michigan
- BS from Duke University
Research
Focus
- My research focuses on statistical techniques for human gene mapping of complex traits. This work involves two synergistic components: a methodological component focused on developing novel statistical techniques for improved gene mapping and an applied component focused on using existing methods to map genes involved in diseases such as schizophrenia.
Publications
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Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.
Alzheimers Res Ther Volume: 17 Page(s): 135
06/18/2025 Authors: Hu T; Liu Q; Dai Q; Buchman AS; Bennett DA; Tasaki S; Wang Y; Seyfried NT; De Jager PL; Epstein MP -
CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data.
Am J Hum Genet
06/10/2025 Authors: Head ST; Dai Q; Schildkraut J; Cutler DJ; Yang J; Epstein MP -
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies.
Epilepsia Volume: 66 Page(s): 2036 - 2045
06/01/2025 Authors: Ellis CA; Ottman R; Epstein MP; Epi4K Consortium; Berkovic SF; Oliver KL -
Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response.
Genes (Basel) Volume: 16
05/14/2025 Authors: Chen J; Epstein MP; Schildkraut JM; Kar SP -
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy.
01/17/2025 Authors: Robinson K; Singh SK; Walkup RB; Fawwal DV; Adeyemo WL; Beaty TH; Butali A; Bux CJ; Chung WK; Cutler DJ -
A powerful framework for differential co-expression analysis of general risk factors.
12/03/2024 Authors: Bass AJ; Cutler DJ; Epstein MP -
Investigating the effect of polygenic background on epilepsy phenotype in 'monogenic' families.
EBioMedicine Volume: 109 Page(s): 105404
11/01/2024 Authors: Oliver KL; Scheffer IE; Ellis CA; Grinton BE; Epi4K Consortium; Berkovic SF; Bahlo M -
Genome-wide study of gene-by-sex interactions identifies risks for cleft palate.
Hum Genet Volume: 143 Page(s): 1341 - 1352
11/01/2024 Authors: Robinson K; Parrish R; Adeyemo WL; Beaty TH; Butali A; Bux CJ; Gowans LJJ; Hecht JT; Moreno Uribe L; Murray JC -
Diet and Survival in Black Women With Epithelial Ovarian Cancer.
JAMA Netw Open Volume: 7 Page(s): e2440279
10/01/2024 Authors: Armidie TA; Bandera EV; Johnson CE; Peres LC; Haller K; Terry P; Akonde M; Peters ES; Cote ML; Hastert TA -
SCAMPI: A scalable statistical framework for genome-wide interaction testing harnessing cross-trait correlations.
09/14/2024 Authors: Bian S; Bass AJ; Liu Y; Wingo AP; Wingo T; Cutler DJ; Epstein MP