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Profile

Martha Diaz Hernandez

  • Department of Orthopaedics
    Instructor
  • (404) 321-6111
  • martha.elena.diaz.hernandez@emory.edu
  • Google Scholar
  • LinkedIn
  • ResearchGate
  • Emory Musculoskeletal Institute
    Orthopaedics
    21 Ortho Lane
Head shot of Martha Diaz Hernandez

Overview

My research focuses on repair and regeneration of intervertebral disc using an integrative approach of stem cell and growth factor. Our research approach involves areas of developmental biology, stem cell differentiation, disc homeostasis and disease. We explore in vitro and in vivo systems to answer complex questions related to disc degeneration and how to promote repair mechanism to prevent degenerative disc disease. Our research used an innovative approach of notochordal differentiation using several genetic and epigenetic approaches. We interrogate the disc cells (Annulus Fibrosus and Nucleus Pulposus) by using culture of stem cells, primary disc cells and transgenic mice models to explore in a wide of events during disc degeneration and repair.

Academic Appointment

  • Instructor, Orthopaedics, Emory University School of Medicine

Education

Degrees

  • PhD from National Autonomous University of Mexico

Research

Publications

  • Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs.
    Cells Volume: 13
    09/04/2024 Authors: Diaz-Hernandez ME; Murakami K; Murata S; Khan NM; Shenoy SPV; Henke K; Yamada H; Drissi H
  • Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health.
    JOR Spine Volume: 7 Page(s): e1306
    03/01/2024 Authors: Zhang C; Gordon MD; Joseph KM; Diaz-Hernandez ME; Drissi H; Illien-Jnger S
  • Efficient Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Mesenchymal Progenitors Into Adipocytes and Osteoblasts.
    Bio Protoc Volume: 13 Page(s): e4885
    11/20/2023 Authors: Diaz-Hernandez ME; Khan NM; Drissi H
  • Differentiation of Human Induced Pluripotent Stem Cells (iPSCs)-derived Mesenchymal Progenitors into Chondrocytes.
    Bio Protoc Volume: 13 Page(s): e4874
    11/05/2023 Authors: Khan NM; Diaz-Hernandez ME; Drissi H
  • DIMETHYL FUMARATE AS A POTENTIAL DISEASE MODIFYING AGENT FOR THE TREATMENT OF KNEE OSTEOARTHRITIS
    Volume: 31 Page(s): S337 - S337
    03/01/2023 Authors: Khan NM; Kaiser J; Diaz-Hernandez ME; Chihab S; Eng T; Drissi H
  • Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures.
    Elife Volume: 12
    01/30/2023 Authors: Khan NM; Diaz-Hernandez ME; Chihab S; Priyadarshani P; Bhattaram P; Mortensen LJ; Guzzo RM; Drissi H
  • pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression.
    PeerJ Volume: 11 Page(s): e16553
    01/01/2023 Authors: Khan NM; Diaz-Hernandez ME; Martin WN; Patel B; Chihab S; Drissi H
  • PHLPP1 deficiency protects against age-related intervertebral disc degeneration.
    JOR Spine Volume: 5 Page(s): e1224
    12/01/2022 Authors: Zhang C; Joseph KM; Khan NM; Diaz-Hernandez ME; Drissi H; Illien-Junger S
  • Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors.
    Endocrinology Volume: 163
    09/01/2022 Authors: Daz-Hernndez ME; Kinter CW; Watson SR; Mella-Velazquez G; Kaiser J; Liu G; Khan NM; Roberts JL; Lorenzo J; Drissi H
  • Runx1 regulates osteoclast differentiation by modulation of redox signaling.
    Volume: 37 Page(s): 300 - 300
    02/01/2022 Authors: Diaz-Hernandez ME; Kinter CW; Mella G; Drissi H; Roberts JL; Khan NM
  • Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers.
    Front Cell Dev Biol Volume: 10 Page(s): 874323
    01/01/2022 Authors: Robinson H; Ali SI; Diaz-Hernandez ME; Lopez-Gonzalez R
  • Activation of the WNT-BMP-FGF Regulatory Network Induces the Onset of Cell Death in Anterior Mesodermal Cells to Establish the ANZ.
    Front Cell Dev Biol Volume: 9 Page(s): 703836
    01/01/2021 Authors: Daz-Hernndez ME; Galvn-Hernndez CI; Marn-Llera JC; Camargo-Sosa K; Bustamante M; Wischin S; Chimal-Monroy J
  • Inhibition of WNT/-catenin is necessary and sufficient to induce Scx expression in developing tendons of chicken limb.
    Int J Dev Biol Volume: 65 Page(s): 395 - 401
    01/01/2021 Authors: Garcia-Lee V; Daz-Hernandez ME; Chimal-Monroy J
  • Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.
    Biomed Pharmacother Volume: 132 Page(s): 110831
    12/01/2020 Authors: Roberts JL; Liu G; Darby TM; Fernandes LM; Diaz-Hernandez ME; Jones RM; Drissi H
  • Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells.
    Sci Rep Volume: 10 Page(s): 15263
    09/17/2020 Authors: Fernandes LM; Khan NM; Trochez CM; Duan M; Diaz-Hernandez ME; Presciutti SM; Gibson G; Drissi H
  • Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration.
    Genes (Basel) Volume: 11
    07/09/2020 Authors: Khan NM; Diaz-Hernandez ME; Presciutti SM; Drissi H
  • Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics.
    J Cell Physiol Volume: 235 Page(s): 5241 - 5255
    06/01/2020 Authors: Diaz-Hernandez ME; Khan NM; Trochez CM; Yoon T; Maye P; Presciutti SM; Gibson G; Drissi H
  • Deletion of Runx1 in osteoclasts impairs murine fracture healing through progressive woven bone loss and delayed cartilage remodeling.
    J Orthop Res Volume: 38 Page(s): 1007 - 1015
    05/01/2020 Authors: Paglia DN; Diaz-Hernandez ME; Roberts JL; Kalinowski J; Lorenzo J; Drissi H
  • Transient transgenesis of the tapeworm Taenia crassiceps.
    Springerplus Volume: 4 Page(s): 496
    01/01/2015 Authors: Moguel B; Moreno-Mendoza N; Bobes RJ; Carrero JC; Chimal-Monroy J; Daz-Hernndez ME; Herrera-Estrella L; Laclette JP
  • The role of plant metabolism in the mutagenic and cytotoxic effects of four organophosphorus insecticides in Salmonella typhimurium and in human cell lines.
    Chemosphere Volume: 92 Page(s): 1117 - 1125
    08/01/2013 Authors: Corts-Eslava J; Gmez-Arroyo S; Arenas-Huertero F; Flores-Maya S; Daz-Hernndez ME; Caldern-Segura ME; Valencia-Quintana R; Espinosa-Aguirre JJ; Villalobos-Pietrini R
  • Irx1 and Irx2 are coordinately expressed and regulated by retinoic acid, TGF and FGF signaling during chick hindlimb development.
    PLoS One Volume: 8 Page(s): e58549
    01/01/2013 Authors: Daz-Hernndez ME; Bustamante M; Galvn-Hernndez CI; Chimal-Monroy J
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