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Jinhu Wang Ph.D.

  • Department of Medicine
    Assistant Professor
Head shot of Jinhu Wang

Overview

Dr. Wang is an assistant professor in Emory University School of Medicine. He received his PhD in Developmental Biology in Chinese Academy of Science. he got his postdoctoral research training in Dr. Kenneth Posss Lab at Duke University. His broad research goal is to understand how regenerative responses to injury have been optimized in non-mammalian vertebrates like zebrafish, to discover new targets that underline the regenerative deficiencies in mammals.

In the past several years, his work was focused on investigating regenerative biology of two major adult cardiac tissues: the myocardium and the epicardium. Using a new Cre-loxP mediated myocardial ablation approach, he and his colleagues showed that depleting up to 60% of myofibers in adult zebrafish heart caused classic indicators of heart failure: gasping, lethargy and reduced exercise capacity. They found that adult zebrafish can fully regenerate lost myocardium and reverse the signs of heart failure within several days, through massive cardiomyocyte proliferation detected throughout the heart. Using a new bacterial nitroreductase ablation system, He and his colleagues demonstrated that the epicardium is required for heart regeneration. Furthermore, their work showed that the epicardium itself has high capacity for renewal and fully regenerates even after 90% loss of epicardial cells.

Academic Appointment

  • Assistant Professor of Medicine, Department of Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from Chinese Academy of Science

Research

Publications

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