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Profile

Janet Klein PhD

  • Department of Medicine
    Associate Professor, Emeritus
  • (404) 727-9933
  • janet.klein@emory.edu
Head shot of Janet Klein

Overview

Dr. Klein received her BS in biochemistry from the University of Scranton and MS and PhD in chemistry from New Mexico State University with a major in biochemistry and a minor in analytical chemistry. Her dissertation described a novel transglutaminase in Physarum polycephalum. Her first postdoctoral position was at the Terre Haute Center for Medical Education, and her second postdoctoral position was with the American Red Cross in Farmington Connecticut. During these postdoctoral fellowships, she studied the protein biochemistry of the coagulation cascade enzymes concentrating on Protein C and Protein S. Her third postdoctoral position brought her to Emory University, working with Dr. Lawrence Philips in the Department of Medicines Division of Endocrinology, Metabolism and Lipids. Following this, she moved to the Division of Renal Medicine and was named an instructor in 1993, an assistant professor of medicine in 1997, and an associate professor of medicine in 2003. Her research interest has always been in protein biochemistry. For the past six years, she has investigated various transport mechanisms in the kidney, with an emphasis on the urea transporters.

1982 present Member, Sigma Xi
2000 2004 Member, International Society of Nephrology
2003 present Member, American Society of Nephrology
1993 2003 Member, American Society for Biochemistry and Molecular Biology
2003 - present Member, American Physiological Society
2004 present Member, Editorial Board, American Journal of Physiology, Renal
2004 2005 Grant Review American Heart Association Peer Review: Molecular Signaling I
2002 present Ext.l Reviewer VA merit award grant applications
2002 present Ext.l Reviewer National Kidney Research Fund Grant Applications UK
2003 present Peer Review AJP, JASN, JBC, KI

The polyuria that occurs in diabetic patients is generally ascribed to an osmotic diuresis. We believe that the mechanisms are more complex. The production of concentrated urine requires complex interactions among the medullary nephron segments and vasculature. A major goal of my research is to identify the cellular and molecular mechanisms that contribute to changes in water and solute homeostasis that occur in uncontrolled diabetes.

Recent reports from the CDC indicate that diabetes mellitus has reached epidemic proportions in the U.S. The polyuria that occurs in diabetic patients is generally ascribed to an osmotic diuresis. We believe that the mechanisms are more complex. Several metabolic and hormonal abnormalities present in diabetes mellitus and could contribute to abnormalities in solute and water handling. A major emphasis of my research is to identify the cellular and molecular mechanisms that contribute to changes in water and solute homeostasis that occur in uncontrolled diabetes. Our recent findings were the first to propose that compensatory changes in renal medullary transport proteins occurred during uncontrolled diabetes. We believe that our research will provide novel insights into the pathophysiology of uncontrolled diabetes. This understanding will be important for designing better therapeutic strategies as new agents, such as selective vasopressin agonists and antagonists, become available for clinical use.

Identifying these mechanisms could provide novel insights into the compensatory mechanisms that must occur in the kidney so that patients with uncontrolled type I diabetes rarely present in hypovolemic shock during conditions associated with volume depletion, such as diabetic ketoacidosis.

Academic Appointment

  • Associate Professor, Medicine - Renal Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from New Mexico State University
  • BS from University of Scranton
  • MS from New Mexico State University

Research

Focus

  • Since becoming a member of the Urea Group at Emory, my research has focused on understanding the kidney transport proteins that are involved in producing a concentrated urine. I particularly want to understand how these proteins contribute to pathologies where the kidney is unable to perform this function.

Publications

  • Aldosterone Contributes to Vasopressin Escape through Changes in Water and Urea Transport.
    Biomedicines Volume: 11
    06/27/2023 Authors: Wang Y; LaRocque LM; Ruiz JA; Rodriguez EL; Sands JM; Klein JD
  • Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts.
    Int J Mol Sci Volume: 24
    03/31/2023 Authors: Wang Y; Klein JD; Sands JM
  • The impact of senescence on muscle wasting in chronic kidney disease.
    J Cachexia Sarcopenia Muscle Volume: 14 Page(s): 126 - 141
    02/01/2023 Authors: Huang Y; Wang B; Hassounah F; Price SR; Klein J; Mohamed TMA; Wang Y; Park J; Cai H; Zhang X
  • Empagliflozin Accelerates Escape from Vasopressin in Rats.
    FASEB J Volume: 36 Suppl 1
    05/01/2022 Authors: Eubanks EE; Rodriguez EL; Klein JD; Sands JM
  • Aldosterone Regulates Vasopressin Escape through Changes in Water and Urea Transporters.
    FASEB J Volume: 36 Suppl 1
    05/01/2022 Authors: Wang Y; LaRocque LM; Sands JM; Klein JD
  • Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure.
    Acta Physiol (Oxf) Volume: 232 Page(s): e13629
    05/01/2021 Authors: Kovarik JJ; Morisawa N; Wild J; Marton A; Takase-Minegishi K; Minegishi S; Daub S; Sands JM; Klein JD; Bailey JL
  • An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus.
    JCI Insight Volume: 6
    04/22/2021 Authors: Klein JD; Khanna I; Pillarisetti R; Hagan RA; LaRocque LM; Rodriguez EL; Sands JM
  • Downregulation of let-7 by Electrical Acupuncture Increases Protein Synthesis in Mice.
    Front Physiol Volume: 12 Page(s): 697139
    01/01/2021 Authors: Huang Y; Yu M; Kuma A; Klein JD; Wang Y; Hassounah F; Cai H; Wang XH
  • Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts.
    Cells Volume: 9
    11/24/2020 Authors: Ma F; Chen G; Rodriguez EL; Klein JD; Sands JM; Wang Y
  • 14-3-3, a novel regulator of the large-conductance Ca2+-activated K+ channel.
    Am J Physiol Renal Physiol Volume: 319 Page(s): F52 - F62
    07/01/2020 Authors: Chen S; Feng X; Chen X; Zhuang Z; Xiao J; Fu H; Klein JD; Wang XH; Hoover RS; Eaton DC
  • Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease.
    FASEB J Volume: 34 Page(s): 8296 - 8309
    06/01/2020 Authors: Kuma A; Wang XH; Klein JD; Tan L; Naqvi N; Rianto F; Huang Y; Yu M; Sands JM
  • UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction.
    Am J Physiol Renal Physiol Volume: 318 Page(s): F1160 - F1166
    05/01/2020 Authors: Rianto F; Kuma A; Ellis CL; Hassounah F; Rodriguez EL; Wang XH; Sands JM; Klein JD
  • Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts.
    Cells Volume: 9
    04/14/2020 Authors: Wang Y; Ma F; Rodriguez EL; Klein JD; Sands JM
  • Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice.
    Hum Gene Ther Volume: 31 Page(s): 367 - 375
    03/01/2020 Authors: Wang B; Wang J; He W; Zhao Y; Zhang A; Liu Y; Hassounah F; Ma F; Klein JD; Wang XH
  • Exogenous miR-26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease.
    FASEB J Volume: 33 Page(s): 13590 - 13601
    12/01/2019 Authors: Zhang A; Wang H; Wang B; Yuan Y; Klein JD; Wang XH
  • High glucose reduces expression of podocin in cultured human podocytes by stimulating TRPC6.
    Am J Physiol Renal Physiol Volume: 317 Page(s): F1605 - F1611
    12/01/2019 Authors: Lu X-Y; Liu B-C; Cao Y-Z; Song C; Su H; Chen G; Klein JD; Zhang H-X; Wang L-H; Ma H-P
  • Regulation of renal urea and water transport: implications for therapy of nephrogenic diabetes insipidus
    Volume: 227 Page(s): 20 - 21
    09/01/2019 Authors: Sands JM; Klein JD
  • Inner Medullary Urea Transporters Contribute to Development of Renal Fibrosis in Mice With Unilateral Ureteral Obstruction
    Volume: 33
    04/01/2019 Authors: Rianto F; Ellis CL; Hassounah F; Wang XH; Klein JD; Sands JM
  • Role of adrenomedullin in mediating water reabsorption in rat inner medullary collecting ducts
    Volume: 33
    04/01/2019 Authors: Wang Y; Ma F; Klein JD
  • Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice.
    Mol Ther Volume: 27 Page(s): 571 - 583
    03/06/2019 Authors: Wang H; Wang B; Zhang A; Hassounah F; Seow Y; Wood M; Ma F; Klein JD; Price SR; Wang XH
  • Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKC-dependent manner.
    FASEB J Volume: 33 Page(s): 3549 - 3561
    03/01/2019 Authors: Zhao L; Bartnikas T; Chu X; Klein J; Yun C; Srinivasan S; He P
  • GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage.
    Am J Physiol Cell Physiol Volume: 316 Page(s): C162 - C174
    02/01/2019 Authors: Okazaki Y; Nakamura K; Takeda S; Yoshizawa I; Yoshida F; Ohshima N; Izumi T; Klein JD; Kumrungsee T; Sands JM
  • MICE LACKING INNER MEDULLARY UREA TRANSPORTERS HAVE REDUCED RENAL FIBROSIS FOLLOWING UNILATERAL URETERAL OBSTRUCTION
    Volume: 67 Page(s): 616 - 616
    02/01/2019 Authors: Rianto F; Ellis CL; Wang XH; Klein JD; Sands JM
  • UPREGULATION OF A UREA TRANSPORTER IN UREMIC HEART IS LINKED TO CARDIAC FIBROSIS
    Volume: 67 Page(s): 617 - 618
    02/01/2019 Authors: Kuma A; Wang XH; Klein JD; Sands JM
  • miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease.
    Theranostics Volume: 9 Page(s): 1864 - 1877
    01/01/2019 Authors: Wang B; Zhang A; Wang H; Klein JD; Tan L; Wang Z-M; Du J; Naqvi N; Liu B-C; Wang XH
  • Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature.
    NMR Biomed Volume: 32 Page(s): e4028
    01/01/2019 Authors: Qi H; Mariager C; Nielsen PM; Schroeder M; Lindhardt J; Nrregaard R; Klein JD; Sands JM; Laustsen C
  • Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181.
    Am J Physiol Renal Physiol Volume: 315 Page(s): F1542 - F1549
    12/01/2018 Authors: Klein JD; Wang XH
  • Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181.
    Am J Physiol Renal Physiol Volume: 315 Page(s): F1542 - F1549
    12/01/2018 Authors: Klein JD; Wang XH
  • miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk.
    J Cachexia Sarcopenia Muscle Volume: 9 Page(s): 755 - 770
    08/01/2018 Authors: Zhang A; Li M; Wang B; Klein JD; Price SR; Wang XH
  • The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.
    J Am Soc Nephrol Volume: 29 Page(s): 1706 - 1719
    06/01/2018 Authors: Nanami M; Pham TD; Kim YH; Yang B; Sutliff RL; Staub O; Klein JD; Lopez-Cayuqueo KI; Chambrey R; Park AY
  • Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.
    J Am Soc Nephrol Volume: 29 Page(s): 1097 - 1107
    04/01/2018 Authors: Kenig-Kozlovsky Y; Scott RP; Onay T; Carota IA; Thomson BR; Gil HJ; Ramirez V; Yamaguchi S; Tanna CE; Heinen S
  • GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.
    J Am Soc Nephrol Volume: 29 Page(s): 857 - 868
    03/01/2018 Authors: Hinze C; Ruffert J; Walentin K; Himmerkus N; Nikpey E; Tenstad O; Wiig H; Mutig K; Yurtdas ZY; Klein JD
  • Protein kinase C deletion causes hypotension and decreased vascular contractility.
    J Hypertens Volume: 36 Page(s): 510 - 519
    03/01/2018 Authors: Wynne BM; McCarthy CG; Szasz T; Molina PA; Chapman AB; Webb RC; Klein JD; Hoover RS
  • Protein Kinase C[alpha] Deletion Causes Hypotension Due to Decreased Vascular Contractility.
    Volume: 70
    09/01/2017 Authors: Wynne BM; McCarthy CG; Szasz T; Klein JD; Webb RC; Martin RS
  • Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle.
    Am J Physiol Renal Physiol Volume: 312 Page(s): F1128 - F1140
    06/01/2017 Authors: Su Z; Klein JD; Du J; Franch HA; Zhang L; Hassounah F; Hudson MB; Wang XH
  • High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
    J Clin Invest Volume: 127 Page(s): 1944 - 1959
    05/01/2017 Authors: Kitada K; Daub S; Zhang Y; Klein JD; Nakano D; Pedchenko T; Lantier L; LaRocque LM; Marton A; Neubert P
  • Muscle-kidney crosstalk through microRNA-29 in chronic kidney disease mouse
    Volume: 31
    04/01/2017 Authors: Wang XH; Escobar EM; Zhang A; Klein JD
  • Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane.
    Am J Physiol Renal Physiol Volume: 311 Page(s): F1189 - F1197
    12/01/2016 Authors: Ren H; Yang B; Ruiz JA; Efe O; Ilori TO; Sands JM; Klein JD
  • Physiological insights into novel therapies for nephrogenic diabetes insipidus.
    Am J Physiol Renal Physiol Volume: 311 Page(s): F1149 - F1152
    12/01/2016 Authors: Sands JM; Klein JD
  • Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats.
    Am J Med Sci Volume: 352 Page(s): 517 - 523
    11/01/2016 Authors: Chen L; LaRocque LM; Efe O; Wang J; Sands JM; Klein JD
  • Urea Transporter B and MicroRNA-200c Differ in Kidney Outer Versus Inner Medulla Following Dehydration.
    Am J Med Sci Volume: 352 Page(s): 296 - 301
    09/01/2016 Authors: Wang J; Wang XH; Wang H; Chen L; Klein JD; Sands JM
  • Urea transport and clinical potential of urearetics.
    Curr Opin Nephrol Hypertens Volume: 25 Page(s): 444 - 451
    09/01/2016 Authors: Klein JD; Sands JM
  • Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.
    JCI Insight Volume: 1
    07/21/2016 Authors: Efe O; Klein JD; LaRocque LM; Ren H; Sands JM
  • Urea transporters and sweat response to uremia.
    Physiol Rep Volume: 4
    06/01/2016 Authors: Keller RW; Bailey JL; Wang Y; Klein JD; Sands JM
  • Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.
    Am J Physiol Renal Physiol Volume: 310 Page(s): F1008 - F1012
    05/15/2016 Authors: Klein JD; Wang Y; Blount MA; Molina PA; LaRocque LM; Ruiz JA; Sands JM
  • Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.
    J Am Soc Nephrol Volume: 27 Page(s): 1448 - 1455
    05/01/2016 Authors: Klein JD; Wang Y; Mistry A; LaRocque LM; Molina PA; Rogers RT; Blount MA; Sands JM
  • Low-Frequency Electrical Stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy by increasing muscle regeneration
    Volume: 30
    04/01/2016 Authors: Wang XH; Klein JD; Wang H
  • NEDD4-2 reduces electroneutral Cl-/HCO3- exchange in mouse cortical collecting duct
    Volume: 30
    04/01/2016 Authors: Truyen DP; Nanami M; Staub O; Sutliff RL; Klein JD; Eladari D; Chambrey R; Wang X; Verlander JW; Wall SM
  • AMPK Stimulates Osmotic Water Permeability in Rat IMCDs
    Volume: 30
    04/01/2016 Authors: Wang Y; Efe O; LaRocque LM; Klein JD; Sands JM
  • Loss of Protein Kinase C Alpha Disrupts Mean Arterial Pressure and Diurnal Rhythm
    Volume: 30
    04/01/2016 Authors: Wynnel BM; Molina P; Klein J; Hoover RS
  • Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy.
    J Appl Physiol (1985) Volume: 120 Page(s): 426 - 436
    02/15/2016 Authors: Su Z; Hu L; Cheng J; Klein JD; Hassounah F; Cai H; Li M; Wang H; Wang XH
  • Activation of protein kinase C increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.
    Am J Physiol Cell Physiol Volume: 309 Page(s): C608 - C615
    11/01/2015 Authors: Blount MA; Cipriani P; Redd SK; Ordas RJ; Black LN; Gumina DL; Hoban CA; Klein JD; Sands JM
  • Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.
    Am J Physiol Renal Physiol Volume: 309 Page(s): F71 - F78
    07/01/2015 Authors: Feng X; Li Z; Du Y; Fu H; Klein JD; Cai H; Sands JM; Chen G
  • AMPK Phosphorylates Urea Transporter A1 and Aquaporin 2 in Rat Inner Medullary Collecting Ducts
    Volume: 29
    04/01/2015 Authors: Ruiz J; Molina P; LaRocque L; Klein J; Sands J
  • ENaC regulation by [Ca2+] i is determined by mitochondrial Ca2+ uptake
    Volume: 29
    04/01/2015 Authors: Thai T; Galarza-Paez L; Yu L; Bao HF; Klein J; Sands J; Eaton D
  • Acupuncture plus Low-Frequency Electrical Stimulation (Acu/LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration
    Volume: 29
    04/01/2015 Authors: Robinson A; Klein J; Wang X
  • AMPK Stimulates Urea Permeability and Urine Osmolality
    Volume: 29
    04/01/2015 Authors: Wang Y; Klein J; Sands J
  • Activation of protein kinase C- and Src kinase increases urea transporter A1 -2, 6 sialylation.
    J Am Soc Nephrol Volume: 26 Page(s): 926 - 934
    04/01/2015 Authors: Li X; Yang B; Chen M; Klein JD; Sands JM; Chen G
  • Low-frequency electrical stimulation attenuates muscle atrophy in CKD--a potential treatment strategy.
    J Am Soc Nephrol Volume: 26 Page(s): 626 - 635
    03/01/2015 Authors: Hu L; Klein JD; Hassounah F; Cai H; Zhang C; Xu P; Wang XH
  • PKC- contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2.
    Am J Physiol Renal Physiol Volume: 308 Page(s): F140 - F148
    01/15/2015 Authors: Wang H; Ferraris JD; Klein JD; Sands JM; Burg MB; Zhou X
  • Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions.
    Front Physiol Volume: 6 Page(s): 310
    01/01/2015 Authors: Chen M; Cai H; Klein JD; Laur O; Chen G
  • NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip.
    PLoS One Volume: 10 Page(s): e0141714
    01/01/2015 Authors: Ren H; Yang B; Molina PA; Sands JM; Klein JD
  • Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration.
    PLoS One Volume: 10 Page(s): e0134511
    01/01/2015 Authors: Su Z; Robinson A; Hu L; Klein JD; Hassounah F; Li M; Wang H; Cai H; Wang XH
  • RNA-seq analysis of glycosylation related gene expression in STZ-induced diabetic rat kidney inner medulla.
    Front Physiol Volume: 6 Page(s): 274
    01/01/2015 Authors: Qian X; Li X; Ilori TO; Klein JD; Hughey RP; Li C-J; Alli AA; Guo Z; Yu P; Song X
  • The Role of PKC-alpha in NCC-Mediated Hypertension
    HYPERTENSION Volume: 64
    09/01/2014 Authors: Wynne BM; Molina P; Klein JD; Hoover RS
  • A letter to a donor: A medical student's perspective after organ procurement.
    Transplantation Volume: 97 Page(s): 1090
    06/15/2014 Authors: Klein J; Kogon BE
  • MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.
    Aging (Albany NY) Volume: 6 Page(s): 160 - 175
    03/01/2014 Authors: Hu Z; Klein JD; Mitch WE; Zhang L; Martinez I; Wang XH
  • ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase C knockout mice.
    Am J Physiol Renal Physiol Volume: 306 Page(s): F309 - F320
    02/01/2014 Authors: Bao H-F; Thai TL; Yue Q; Ma H-P; Eaton AF; Cai H; Klein JD; Sands JM; Eaton DC
  • Aging increases CCN1 expression leading to muscle senescence.
    Am J Physiol Cell Physiol Volume: 306 Page(s): C28 - C36
    01/01/2014 Authors: Du J; Klein JD; Hassounah F; Zhang J; Zhang C; Wang XH
  • Expression of urea transporters and their regulation.
    Subcell Biochem Volume: 73 Page(s): 79 - 107
    01/01/2014 Authors: Klein JD
  • Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor.
    Biochim Biophys Acta Volume: 1833 Page(s): 2143 - 2152
    10/01/2013 Authors: Salyer SA; Parks J; Barati MT; Lederer ED; Clark BJ; Klein JD; Khundmiri SJ
  • Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.
    Am J Physiol Renal Physiol Volume: 305 Page(s): F645 - F652
    09/01/2013 Authors: Ko B; Mistry AC; Hanson L; Mallick R; Wynne BM; Thai TL; Bailey JL; Klein JD; Hoover RS
  • DUPLICATION OF THE UREA TRANSPORTER B GENE (KIDD BLOOD GROUP) IN A KINDRED WITH FAMILIAL AZOTEMIA
    VOX SANGUINIS Volume: 105 Page(s): 30 - 31
    06/01/2013 Authors: Haer-Wigman L; Linthorst GE; Sands JM; Klein JD; Thai TL; Verhoeven AJ; van Zwieten R; Folman C; Jansweijer MC; Knegt LC
  • Increased UT-A1 ubiquitination is partially due to decreased deubiquitination activity in Streptozotocin-induced diabetic rat kidney inner medulla
    Volume: 27
    04/01/2013 Authors: Su H; Ilori TO; Klein JD; Sands JM; Chen G
  • TRANSGENIC MICE EXPRESSING UT-A1, BUT LACKING UT-A3, HAVE INTACT URINE CONCENTRATING ABILITY
    Volume: 27
    04/01/2013 Authors: Klein JD; Froehlich O; Mistry AC; Kent KJ; Martin CF; Sands JM
  • Mice lacking protein kinase C alpha show enhanced membrane localization and activity of the epithelial sodium channel (ENaC) in the renal cortical collecting duct
    Volume: 27
    04/01/2013 Authors: Bao H-F; Yue Q; Thai TL; Klein JD; Sands JM; Eaton DC
  • ACUTE ALDOSTERONE AFFECTS NCC VIA A SPAK-MEDIATED PATHWAY
    Volume: 61 Page(s): 777 - 777
    04/01/2013 Authors: Ko B; Hanson L; Mistry A; Mallick R; Thai T; Bailey J; Klein J; Hoover R
  • Acute Effects of Aldosterone on NCC Are Mediated by SPAK
    Volume: 27
    04/01/2013 Authors: Ko B; Hanson L; Mistry A; Thai TL; Mallick R; Klein JD; Bailey JL; Hoover R
  • Role of protein kinase C- in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts.
    Am J Physiol Renal Physiol Volume: 304 Page(s): F233 - F238
    01/15/2013 Authors: Wang Y; Klein JD; Froehlich O; Sands JM
  • Urine concentration in the diabetic mouse requires both urea and water transporters.
    Am J Physiol Renal Physiol Volume: 304 Page(s): F103 - F111
    01/01/2013 Authors: Ilori TO; Blount MA; Martin CF; Sands JM; Klein JD
  • Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats.
    PLoS One Volume: 8 Page(s): e54738
    01/01/2013 Authors: Bou Matar RN; Klein JD; Sands JM
  • Molecular mechanisms of urea transport in health and disease.
    Pflugers Arch Volume: 464 Page(s): 561 - 572
    12/01/2012 Authors: Klein JD; Blount MA; Sands JM
  • Lack of protein kinase C- leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.
    Am J Physiol Renal Physiol Volume: 303 Page(s): F37 - F44
    07/01/2012 Authors: Thai TL; Blount MA; Klein JD; Sands JM
  • Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs. non-pair-fed rats.
    Am J Physiol Renal Physiol Volume: 302 Page(s): F1545 - F1553
    06/15/2012 Authors: Bou Matar RN; Malik B; Wang XH; Martin CF; Eaton DC; Sands JM; Klein JD
  • Protein kinase C- mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.
    Am J Physiol Renal Physiol Volume: 302 Page(s): F1098 - F1103
    05/01/2012 Authors: Klein JD; Martin CF; Kent KJ; Sands JM
  • Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.
    Am J Physiol Renal Physiol Volume: 302 Page(s): F998 - F1004
    04/15/2012 Authors: Ilori TO; Wang Y; Blount MA; Martin CF; Sands JM; Klein JD
  • Role of PKC alpha in Hypertonicity-stimulated Urea Permeability
    Volume: 26
    04/01/2012 Authors: Wang Y; Klein JD; Froehlich O; Sands JM
  • The urea transporter UT-A1 is phosphorylated at serines 486 and 499 downstream of cyclic AMP production
    Volume: 26
    04/01/2012 Authors: Thai TL; Gumina DL; Ilori TO; Klein JD; Blount MA; Sands JM
  • LACK OF PROTEIN KINASE C alpha LEADS TO IMPAIRED URINE CONCENTRATING ABILITY AND DECREASED AQUAPORIN-2 IN ANGIOTENSIN II-INDUCED HYPERTENSION
    Volume: 60 Page(s): 425 - 425
    01/01/2012 Authors: Thai TL; Blount MA; Klein JD; Sands JM
  • The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus.
    Front Physiol Volume: 3 Page(s): 176
    01/01/2012 Authors: Cipriani P; Kim SL; Klein JD; Sim JH; von Bergen TN; Blount MA
  • ACUTE CALCINEURIN INHIBITION WITH TACROLIMUS INCREASES PHOSPHORYLATION OF UT-A1 AT SERINE 486
    Volume: 60 Page(s): 385 - 385
    01/01/2012 Authors: Ilori TO; Wang Y; Blount MA; Sands J; Klein JD
  • PROTEIN ABUNDANCE OF UREA TRANSPORTERS AND AQUAPORIN 2 CHANGE DIFFERENTLY IN NEPHROTIC PAIR-FED VERSUS NON-PAIR-FED RATS
    Volume: 60 Page(s): 384 - 384
    01/01/2012 Authors: Matar BR; Sands J; Klein J
  • Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization.
    FASEB J Volume: 25 Page(s): 4531 - 4539
    12/01/2011 Authors: Chen G; Howe AG; Xu G; Frhlich O; Klein JD; Sands JM
  • Cyclooxygenase-2 in the kidney: good, BAD, or both?
    Kidney Int Volume: 80 Page(s): 905 - 907
    11/01/2011 Authors: Russ Price S; Klein JD
  • Decreased miR-29 suppresses myogenesis in CKD.
    J Am Soc Nephrol Volume: 22 Page(s): 2068 - 2076
    11/01/2011 Authors: Wang XH; Hu Z; Klein JD; Zhang L; Fang F; Mitch WE
  • N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.
    Am J Physiol Renal Physiol Volume: 301 Page(s): F44 - F54
    07/01/2011 Authors: Sproul A; Steele SL; Thai TL; Yu S; Klein JD; Sands JM; Bell PD
  • The Urea Transporter UT-A1 is Directly Phosphorylated by PKC
    Volume: 25
    04/01/2011 Authors: Redd SK; Cipriani P; Ordas R; Klein JD; Blount MA; Sands JM
  • Urea transport in the kidney.
    Compr Physiol Volume: 1 Page(s): 699 - 729
    04/01/2011 Authors: Klein JD; Blount MA; Sands JM
  • Increases in Aquaporins-2 cannot compensate for the loss of Urea transporters UT-A1 and UT-A3 in Diabetic animals
    Volume: 25
    04/01/2011 Authors: Ilori TO; Denson C; Sands J; Klein J
  • Phosphorylation of UT-A1 at S486 and S499 is a Rapid and Non-Redundant Response to Increased Intercellular cAMP
    Volume: 25
    04/01/2011 Authors: Blount MA; Hoban CA; Gumina DL; Klein JD; Sands JM
  • Lack of PKC alpha leads to Altered Urea Transporter UT-A1 and Aquaporin-2 in Angiotensin II-induced Hypertension
    Volume: 25
    04/01/2011 Authors: Thai TL; Klein JD; Sands JM
  • N-LINKED GLYCOSYLATION IS REQUIRED FOR UT-A1 UREA TRANSPORTER TRAFFICKING INTO THE MEMBRANE LIPID RAFT SUBDOMAINS
    Volume: 25
    04/01/2011 Authors: Chen G; Howe AG; Froehlich O; Klein JD; Sands JM
  • Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor- and its receptor 1.
    Kidney Int Volume: 79 Page(s): 613 - 623
    03/01/2011 Authors: Huang L; Zhang R; Wu J; Chen J; Grosjean F; Satlin LH; Klein JD; Sands JM; Striker GE; Tan J
  • MEMBRANE ACCUMULATION OF THE UREA TRANSPORTER IN THE DIABETIC RAT KIDNEY
    Volume: 59 Page(s): 461 - 462
    02/01/2011 Authors: Ilori TO; Thai T; Martin C; Blount MA; Sands JM; Klein JD
  • DECREASED AQUAPORIN 2 AND UREA TRANSPORTER ABUNDANCES IN A RAT MODEL OF NEPHROTIC SYNDROME
    Volume: 59 Page(s): 530 - 530
    02/01/2011 Authors: Matar BR; Sands J; Klein J
  • Regulation of renal urea transport by vasopressin.
    Trans Am Clin Climatol Assoc Volume: 122 Page(s): 82 - 92
    01/01/2011 Authors: Sands JM; Blount MA; Klein JD
  • Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.
    Am J Physiol Renal Physiol Volume: 299 Page(s): F1401 - F1406
    12/01/2010 Authors: Wang Y; Klein JD; Liedtke CM; Sands JM
  • Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways.
    Am J Physiol Renal Physiol Volume: 299 Page(s): F1389 - F1395
    12/01/2010 Authors: Huang H; Feng X; Zhuang J; Frhlich O; Klein JD; Cai H; Sands JM; Chen G
  • Corin: an ANP protease that may regulate sodium reabsorption in nephrotic syndrome.
    Kidney Int Volume: 78 Page(s): 635 - 637
    10/01/2010 Authors: Klein JD
  • Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
    J Biol Chem Volume: 285 Page(s): 27869 - 27878
    09/03/2010 Authors: He P; Klein J; Yun CC
  • XIAP reduces muscle proteolysis induced by CKD.
    J Am Soc Nephrol Volume: 21 Page(s): 1174 - 1183
    07/01/2010 Authors: Hu J; Du J; Zhang L; Price SR; Klein JD; Wang XH
  • Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.
    Am J Physiol Cell Physiol Volume: 298 Page(s): C1431 - C1437
    06/01/2010 Authors: Mistry AC; Mallick R; Klein JD; Sands JM; Frhlich O
  • Target ranges of oxygen saturation in extremely preterm infants.
    N Engl J Med Volume: 362 Page(s): 1959 - 1969
    05/27/2010 Authors: SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network; Carlo WA; Finer NN; Walsh MC; Rich W; Gantz MG; Laptook AR; Yoder BA; Faix RG; Das A
  • Suppression subtractive hybridization analysis of low-protein diet- and vitamin D-induced gene expression from rat kidney inner medullary base.
    Physiol Genomics Volume: 41 Page(s): 203 - 211
    05/01/2010 Authors: Chen G; Yang Y; Frhlich O; Klein JD; Sands JM
  • Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.
    Am J Physiol Cell Physiol Volume: 298 Page(s): C1018 - C1028
    05/01/2010 Authors: Park HJ; Rajbhandari I; Yang HS; Lee S; Cucoranu D; Cooper DS; Klein JD; Sands JM; Choi I
  • Evidence for Aldosterone-mediated regulation of Na-K ATPase in kidney proximal tubules
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Parks J; Barati MT; Salyer SA; Mandal A; Klein JD; Khundmiri SJ
  • The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure.
    Blood Volume: 115 Page(s): 2704 - 2708
    04/01/2010 Authors: Spellman S; Bray R; Rosen-Bronson S; Haagenson M; Klein J; Flesch S; Vierra-Green C; Anasetti C
  • An SP/TP motif in the N-terminal cytoplasmic domain of UT-A3 as potential activation site of UT-A3-mediated urea transport
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Mistry A; Mallick R; Klein JD; Sands JM; Froehlich O
  • The Role of Nitric Oxide in the Urine Concentration Mechanism in Diabetic Rats
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Cipriani P; Kim SL; Klein JD; Denson CE; Sim JH; Sands JM; Blount MA
  • Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.
    Am J Physiol Renal Physiol Volume: 298 Page(s): F935 - F940
    04/01/2010 Authors: Klein JD; Blount MA; Frhlich O; Denson CE; Tan X; Sim JH; Martin CF; Sands JM
  • Hyperosmolarity stimulates heat shock protein 40 and 70 interaction with UT-A1 urea transporter
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Chen G; Feng X; Frohlich O; Yang Y; Klein JD; Sands JM
  • Hypertonicity Increases Urea Permeability through PKC in Inner Medullary Collecting Ducts
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Wang Y; Klein JD; Sands JM
  • Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment.
    Am J Physiol Renal Physiol Volume: 298 Page(s): F601 - F608
    03/01/2010 Authors: Blount MA; Sim JH; Zhou R; Martin CF; Lu W; Sands JM; Klein JD
  • THE ROLE OF NITRIC OXIDE IN THE URINE CONCENTRATION MECHANISM IN DIABETIC RATS
    Volume: 58 Page(s): 427 - 427
    02/01/2010 Authors: Cipriani P; Kim SL; Klein JD; Denson CE; Sim JH; Sands JM; Blount MA
  • Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function.
    Kidney Int Volume: 76 Page(s): 751 - 759
    10/01/2009 Authors: Wang XH; Du J; Klein JD; Bailey JL; Mitch WE
  • Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.
    J Am Soc Nephrol Volume: 20 Page(s): 2018 - 2024
    09/01/2009 Authors: Wang Y; Klein JD; Blount MA; Martin CF; Kent KJ; Pech V; Wall SM; Sands JM
  • Exposure to tobacco on the internet: content analysis of adolescents' internet use.
    Pediatrics Volume: 124 Page(s): e180 - e186
    08/01/2009 Authors: Jenssen BP; Klein JD; Salazar LF; Daluga NA; DiClemente RJ
  • Syntaxin specificity of aquaporins in the inner medullary collecting duct.
    Am J Physiol Renal Physiol Volume: 297 Page(s): F292 - F300
    08/01/2009 Authors: Mistry AC; Mallick R; Klein JD; Weimbs T; Sands JM; Frhlich O
  • Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane.
    Am J Physiol Renal Physiol Volume: 296 Page(s): F1514 - F1520
    06/01/2009 Authors: Feng X; Huang H; Yang Y; Frhlich O; Klein JD; Sands JM; Chen G
  • Epac Regulation of Urea Transport and the UT-A1 Urea Transporter in Rat Inner Medullary Collecting Duct
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Wang Y; Klein JD; Martin C; Kent K; Wall SM; Sands JM
  • Epac Regulation of Urea Transport and the UT-A1 Urea Transporter in Rat Inner Medullary Collecting Duct
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Wang Y; Klein JD; Martin CF; Kent KJ; Wall SM; Sands JM
  • Cell surface UT-A1 is sequestered in lipid rafts and phosphorylated and ubiquitinated in non-raft membrane domains
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Feng X; Yang Y; Froehlich O; Klein JD; Sands JM; Chen G
  • A global benchmark study using affinity-based biosensors.
    Anal Biochem Volume: 386 Page(s): 194 - 216
    03/15/2009 Authors: Rich RL; Papalia GA; Flynn PJ; Furneisen J; Quinn J; Klein JS; Katsamba PS; Waddell MB; Scott M; Thompson J
  • Candesartan Differentially Regulates Epithelial Sodium Channel in Cortex Versus Medulla of Streptozotocin-Induced Diabetic Rats.
    J Epithel Biol Pharmacol Volume: 2 Page(s): 23
    01/01/2009 Authors: Klein JD; Rash A; Sands JM; Ecelbarger CM; Tiwari S
  • Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.
    Am J Physiol Renal Physiol Volume: 296 Page(s): F67 - F77
    01/01/2009 Authors: Kim Y-M; Kim W-Y; Lee H-W; Kim J; Kwon HM; Klein JD; Sands JM; Kim D
  • Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2.
    J Appl Physiol (1985) Volume: 105 Page(s): 1772 - 1778
    12/01/2008 Authors: Gao Y; Ordas R; Klein JD; Price SR
  • Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice.
    Volume: 295 Page(s): F1715 - F1724
    12/01/2008 Authors: Zhang Y; Sands JM; Kohan DE; Nelson RD; Martin CF; Carlson NG; Kamerath CD; Ge Y; Klein JD; Kishore BK
  • MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.
    Am J Physiol Renal Physiol Volume: 295 Page(s): F1528 - F1534
    11/01/2008 Authors: Chen G; Huang H; Frhlich O; Yang Y; Klein JD; Price SR; Sands JM
  • Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency.
    Endocrinology Volume: 149 Page(s): 5384 - 5390
    11/01/2008 Authors: Hu J; Klein JD; Du J; Wang XH
  • Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.
    Am J Physiol Renal Physiol Volume: 295 Page(s): F1336 - F1341
    11/01/2008 Authors: Blessing NW; Blount MA; Sands JM; Martin CF; Klein JD
  • Phosphorylation of the UT-A1 by PKA at serines 486 and 499 is important to vasopressin regulation of urea transport
    Volume: 52 Page(s): E70 - E70
    10/01/2008 Authors: Blount MA; Mistry AC; Froehlich O; Chen G; Sands JM; Klein JD
  • Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.
    Am J Physiol Renal Physiol Volume: 295 Page(s): F295 - F299
    07/01/2008 Authors: Blount MA; Mistry AC; Frhlich O; Price SR; Chen G; Sands JM; Klein JD
  • Candida infective endocarditis.
    Eur J Clin Microbiol Infect Dis Volume: 27 Page(s): 519 - 529
    07/01/2008 Authors: Baddley JW; Benjamin DK; Patel M; Mir J; Athan E; Barsic B; Bouza E; Clara L; Elliott T; Kanafani Z
  • Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney.
    Am J Physiol Renal Physiol Volume: 294 Page(s): F1448 - F1452
    06/01/2008 Authors: Blount MA; Sands JM; Kent KJ; Smith TD; Price SR; Klein JD
  • Dynamin regulates UT-A1 urea transporter membrane expression
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Huang H; Zhuang J; Froehlich O; Yang Y; Klein JD; Cai H; Sands JM; Chen G
  • AVP causes transient formation of cAMP and activation of phosphodiesterase activity in MDCK cells
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Froehlich O; Blount MA; Yang Y; Klein JD; Sands JM
  • Transport proteins in the inner medullas of diabetic kidneys are further increased by candesartan
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Blount MA; Sands JM; Kent KJ; Smith TD; Klein JD
  • Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.
    Am J Physiol Renal Physiol Volume: 294 Page(s): F812 - F820
    04/01/2008 Authors: Bedford JJ; Leader JP; Jing R; Walker LJ; Klein JD; Sands JM; Walker RJ
  • Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium.
    Am J Physiol Renal Physiol Volume: 294 Page(s): F518 - F524
    03/01/2008 Authors: Frhlich O; Aggarwal D; Klein JD; Kent KJ; Yang Y; Gunn RB; Sands JM
  • Candesartan augments the compensatory changes in medullary transport proteins in the diabetic rat kidney
    Volume: 56 Page(s): 452 - 452
    01/01/2008 Authors: Blount MA; Sands JM; Kent KJ; Smith TD; Klein JD
  • The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.
    J Biol Chem Volume: 282 Page(s): 30097 - 30106
    10/12/2007 Authors: Mistry AC; Mallick R; Frhlich O; Klein JD; Rehm A; Chen G; Sands JM
  • Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.
    Am J Physiol Renal Physiol Volume: 293 Page(s): F1308 - F1313
    10/01/2007 Authors: Blount MA; Klein JD; Martin CF; Tchapyjnikov D; Sands JM
  • X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice.
    Gene Ther Volume: 14 Page(s): 711 - 720
    05/01/2007 Authors: Wang XH; Hu J; Du J; Klein JD
  • The apical membrane is the rate-determining barrier for vasopressin-regulated trans-epithelial urea transport in MDCK-UTA1 cells
    Volume: 21 Page(s): A906 - A906
    04/01/2007 Authors: Froehlich O; Yang Y; Klein JD; Sands JM
  • Candesartan differentially regulates distal sodium transporters and channel subunits in cortex versus medulla in streptozotocin-induced diabetic rats.
    Volume: 21 Page(s): A1331 - A1331
    04/01/2007 Authors: Tiwari S; Halagappa VKM; Klein JD; Sands JM; Ecelbarger CA
  • The role of SNARE proteins in trafficking and function of Urea Transporter UT-A1
    Volume: 21 Page(s): A906 - A906
    04/01/2007 Authors: Mistry AC; Mallick R; Klein JD; Froehlich O; Weimbs T; Chen G; Sands JM
  • UT-A3: is it an apical or basolateral membrane urea transporter?
    Volume: 21 Page(s): A906 - A907
    04/01/2007 Authors: Blount MA; Sands JM; Martin CF; Klein JD
  • cAMP/adenylyl cyclase stimulation promotes 14-3-3 binding to UT-A1 urea transporter
    Volume: 21 Page(s): A906 - A906
    04/01/2007 Authors: Chen G; Li Z; Klein JD; Yang Y; Frhlich O; Du Y; Fu H; Sands JM
  • Increased urinary concentrating ability of P2Y2 receptor null mice is associated with marked increase in protein abundances of AQP2 and UT-A in renal medulla
    Volume: 21 Page(s): A905 - A905
    04/01/2007 Authors: Kishore BK; Sands JM; Kohan DE; Martin CF; Ge Y; Nelson RD; Klein JD
  • Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension.
    Am J Physiol Renal Physiol Volume: 291 Page(s): F952 - F959
    11/01/2006 Authors: Klein JD; Murrell BP; Tucker S; Kim Y-H; Sands JM
  • Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.
    J Am Soc Nephrol Volume: 17 Page(s): 2680 - 2686
    10/01/2006 Authors: Klein JD; Frhlich O; Blount MA; Martin CF; Smith TD; Sands JM
  • Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.
    Am J Physiol Cell Physiol Volume: 291 Page(s): C600 - C606
    10/01/2006 Authors: Frhlich O; Klein JD; Smith PM; Sands JM; Gunn RB
  • Loss of N-linked glycosylation reduces urea transporter UT-A1 response to vasopressin.
    J Biol Chem Volume: 281 Page(s): 27436 - 27442
    09/15/2006 Authors: Chen G; Frhlich O; Yang Y; Klein JD; Sands JM
  • Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism.
    Am J Physiol Renal Physiol Volume: 291 Page(s): F186 - F195
    07/01/2006 Authors: Yang JY; Tam WY; Tam S; Guo H; Wu X; Li G; Chau JFL; Klein JD; Chung SK; Sands JM
  • Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein.
    Am J Physiol Renal Physiol Volume: 291 Page(s): F218 - F224
    07/01/2006 Authors: Cai Q; Keck M; McReynolds MR; Klein JD; Greer K; Sharma K; Hoying JB; Sands JM; Brooks HL
  • Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.
    Am J Physiol Renal Physiol Volume: 290 Page(s): F1443 - F1452
    06/01/2006 Authors: Seshadri RM; Klein JD; Smith T; Sands JM; Handlogten ME; Verlander JW; Weiner ID
  • Tissue distribution of UT-A and UT-B mRNA and protein in rat.
    Am J Physiol Regul Integr Comp Physiol Volume: 290 Page(s): R1446 - R1459
    05/01/2006 Authors: Doran JJ; Klein JD; Kim YH; Smith TD; Kozlowski SD; Gunn RB; Sands JM
  • Ubiquitination regulates urea transporter UT-A1 cell membrane expression
    Volume: 20 Page(s): A1218 - A1218
    03/07/2006 Authors: Chen GP; Frohlich OO; Mistry AC; Yang Y; Klein JD; Price SR; Sands JM
  • Vasopressin increases plasma membrane accumulation of the UT-A1 urea transporter in rat inner medullary collecting ducts
    Volume: 20 Page(s): A1218 - A1218
    03/07/2006 Authors: Klein JD; Froehlich O; Smith TD; Sands JM
  • Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
    Am J Physiol Renal Physiol Volume: 290 Page(s): F397 - F408
    02/01/2006 Authors: Seshadri RM; Klein JD; Kozlowski S; Sands JM; Kim Y-H; Han K-H; Handlogten ME; Verlander JW; Weiner ID
  • Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.
    Kidney Int Volume: 69 Page(s): 304 - 312
    01/01/2006 Authors: Tian Y; Riazi S; Khan O; Klein JD; Sugimura Y; Verbalis JG; Ecelbarger CA
  • Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney.
    J Membr Biol Volume: 212 Page(s): 139 - 144
    01/01/2006 Authors: Klein JD; Kozlowski S; Antoun TA; Sands JM
  • Down-regulation of the urea transporter UT-A1 by mineralocorticoids in the diabetic kidney.
    Volume: 54 Page(s): S311 - S311
    01/01/2006 Authors: Antoun TA; Sands JM; Klein JD
  • Vasopressin increases urea permeability in the initial IMCD from diabetic rats.
    Am J Physiol Renal Physiol Volume: 289 Page(s): F531 - F535
    09/01/2005 Authors: Pech V; Klein JD; Kozlowski SD; Wall SM; Sands JM
  • Mobilizing communities for teen pregnancy prevention: associations between coalition characteristics and perceived accomplishments.
    J Adolesc Health Volume: 37 Page(s): S31 - S41
    09/01/2005 Authors: Kegler MC; Williams CW; Cassell CM; Santelli J; Kegler SR; Montgomery SB; Bell ML; Martinez YG; Klein JD; Mulhall P
  • Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load.
    Am J Physiol Renal Physiol Volume: 289 Page(s): F451 - F458
    08/01/2005 Authors: Inoue H; Kozlowski SD; Klein JD; Bailey JL; Sands JM; Bagnasco SM
  • ALDOSE REDUCTASE PROTECTS RENAL COLLECTING TUBULE EPITHELIAL CELLS FROM HYPEROSMOLALITY-INDUCED DNA DAMAGE
    NEPHROLOGY Volume: 10 Page(s): A344 - A344
    06/01/2005 Authors: Tam WY; Yang JY; Li GH; Guo H; Wu XC; Chau FL; Tam S; Chung SK; Klein JD; Sands JM
  • Vasopressin increases urea permeability in initial IMCDs from diabetic rats
    Volume: 19 Page(s): A587 - A587
    03/04/2005 Authors: Pech V; Kozlowski SD; Klein JD; Wall SM; Sands JM
  • Lithium activates urea transport in UT-A1-expressing MDCK cells
    Volume: 19 Page(s): A589 - A589
    03/04/2005 Authors: Aggarwal D; Gunn RB; Klein JD; Sands JM; Frohlich O
  • Vasopressin activates urea transport by non-PKA mediated pathways
    Volume: 19 Page(s): A589 - A590
    03/04/2005 Authors: Frohlich O; Klein JD; Sands JM; Gunn RB
  • Rab14 GTPase interacts with UT-A1 C-terminus: possible role as a regulatory factor of urea transporter activity
    Volume: 19 Page(s): A589 - A589
    03/04/2005 Authors: Chen GP; Gunn RB; Frohlich O; Yang Y; Klein JD; Smith PM; Sands JM
  • Urea may regulate urea transporter protein abundance during osmotic diuresis.
    Am J Physiol Renal Physiol Volume: 288 Page(s): F188 - F197
    01/01/2005 Authors: Kim D; Klein JD; Racine S; Murrell BP; Sands JM
  • Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon.
    Volume: 287 Page(s): C30 - C35
    07/01/2004 Authors: Inoue H; Jackson SD; Vikulina T; Klein JD; Tomita K; Bagnasco SM
  • Urea transport in MDCK cells that are stably transfected with UT-A1.
    Am J Physiol Cell Physiol Volume: 286 Page(s): C1264 - C1270
    06/01/2004 Authors: Frhlich O; Klein JD; Smith PM; Sands JM; Gunn RB
  • Altered expression of urea transporters in response to ureteral obstruction.
    Am J Physiol Renal Physiol Volume: 286 Page(s): F1154 - F1162
    06/01/2004 Authors: Li C; Klein JD; Wang W; Knepper MA; Nielsen S; Sands JM; Frkiaer J
  • Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B.
    J Am Soc Nephrol Volume: 15 Page(s): 1161 - 1167
    05/01/2004 Authors: Klein JD; Sands JM; Qian L; Wang X; Yang B
  • Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats.
    Am J Physiol Renal Physiol Volume: 286 Page(s): F760 - F766
    04/01/2004 Authors: Kim D; Sands JM; Klein JD
  • Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs.
    J Anim Sci Volume: 82 Page(s): 1157 - 1164
    04/01/2004 Authors: Marini JC; Klein JD; Sands JM; Van Amburgh ME
  • Quantitative measurements of the electroneutral Na/bicarbonate cotransporter (NBCn1) expression in chronic metabolic acidosis
    Volume: 18 Page(s): A1018 - A1018
    03/24/2004 Authors: Cucoranu D; Cooper DS; Shyntum DY; Chen GP; Klein JD; Sands JM; Choi I
  • UT-A1 is expressed in the apical membrane of stably transfected MDCK cells
    Volume: 18 Page(s): A1019 - A1019
    03/24/2004 Authors: Klein JD; Froehlich O; Smith PM; Gunn RB; Sands JM
  • Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in transgenic mice lacking urea transporter UT-B
    Volume: 18 Page(s): A1018 - A1018
    03/24/2004 Authors: Yang BX; Sands JM; Qian LM; Wang XD; Klein JD
  • Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor.
    J Am Soc Nephrol Volume: 15 Page(s): 558 - 565
    03/01/2004 Authors: Gertner RA; Klein JD; Bailey JL; Kim D-U; Luo XH; Bagnasco SM; Sands JM
  • Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium.
    Transplantation Volume: 77 Page(s): 259 - 267
    01/27/2004 Authors: Tong DC; Buck SM; Roberts BR; Klein JD; Tumlin JA
  • Urine urea may regulate the abundance of the UT-A1 urea transporter during osmotic diuresis.
    Volume: 14 Page(s): 74A - 75A
    11/01/2003 Authors: Kim D; Klein JD; Sands JM
  • Urea transport may be regulated by phosphorylation of UT-A1 in stably transfected MDCK cells.
    Volume: 14 Page(s): 74A - 74A
    11/01/2003 Authors: Klein JD; Frohlich O; Smith PM; Bagnasco SM; Gunn RB; Sands JM
  • Glucocorticoids and mineralocorticoids decrease UT-A1 abundance by different pathways.
    Volume: 14 Page(s): 74A - 74A
    11/01/2003 Authors: Gertner RA; Klein JD; Kim D; Bailey JL; Sands JM
  • Urea inhibits UT-A mRNA expression.
    Volume: 14 Page(s): 75A - 75A
    11/01/2003 Authors: Inoue H; Vikulina T; Peng T; Klein J; Sands JM; Bagnasco SM
  • Awareness: Monitoring versus remembering what happened.
    Anesthesiology Volume: 99 Page(s): 570 - 575
    09/01/2003 Authors: Kerssens C; Klein J; Bonke B
  • Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats.
    Am J Physiol Renal Physiol Volume: 285 Page(s): F303 - F309
    08/01/2003 Authors: Kim D; Sands JM; Klein JD
  • Transport of urea across epithelial membranes of MDCK cells expressing UT-A1
    Volume: 122 Page(s): 43A - 43A
    07/01/2003 Authors: Gunn RB; Froehlich OA; Smith PM; Klein JD; Bagnasco SM; Sands JM
  • Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle.
    Hypertension Volume: 41 Page(s): 1131 - 1135
    05/01/2003 Authors: Jiang G; Cobbs S; Klein JD; O'Neill WC
  • Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes.
    Neuroendocrinology Volume: 77 Page(s): 246 - 257
    04/01/2003 Authors: Advis JP; Klein J; Kuljis RO; Sarkar DK; McDonald JM; Conover CA
  • UT-A abundance is increased in rat kidney cortex by a low protein diet
    Volume: 17 Page(s): A484 - A484
    03/14/2003 Authors: Klein JD; Doran JJ; Sands JM
  • UT-A1 is up-regulated by both Diabetes metlitus and vasopressin in the Brattleboro rat
    Volume: 17 Page(s): A484 - A484
    03/14/2003 Authors: Kim D; Sands JM; Gertner RA; Klein JD
  • Aldosterone decreases urea transporter protein in the inner medulla of adrenalectomized rats.
    Volume: 51 Page(s): S295 - S295
    02/01/2003 Authors: Gertner RA; Klein JD; Bailey JL; Sands JM
  • Aldosterone decreases urea transporter protein in the inner medulla of adrenalectomized rats.
    Volume: 51 Page(s): S273 - S274
    02/01/2003 Authors: Gertner RA; Klein JD; Bailey JL; Sands JM
  • Aldosterone decreases UT-A1 urea transporter in the rat inner medulla.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 69A - 69A
    09/01/2002 Authors: Klein JD; Luo XH; Wang XD; Reyes MI; Sands JM
  • Regulation of renal transporter abundances in diabetic rats.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 67A - 67A
    09/01/2002 Authors: Kim DU; Klein JD; Meireles CL; Sands JM
  • Expression of UT-A transcripts in the kidney of acidotic rats.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 69A - 69A
    09/01/2002 Authors: Bagnasco SM; Klavuniemi T; Jackson S; Vikulina T; Klein JD
  • Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport.
    Am J Physiol Renal Physiol Volume: 283 Page(s): F578 - F582
    09/01/2002 Authors: Wagner L; Klein JD; Sands JM; Baylis C
  • Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins.
    Am J Physiol Renal Physiol Volume: 283 Page(s): F517 - F524
    09/01/2002 Authors: Klein JD; Le Quach D; Cole JM; Disher K; Mongiu AK; Wang X; Bernstein KE; Sands JM
  • Molecular and functional characterization of a urea transporter from the kidney of a short-finned pilot whale.
    Am J Physiol Regul Integr Comp Physiol Volume: 282 Page(s): R1490 - R1500
    05/01/2002 Authors: Janech MG; Chen R; Klein J; Nowak MW; McFee W; Paul RV; Fitzgibbon WR; Ploth DW
  • Altered expression of urea transporters in rat kidneys in response to urinary tract obstruction.
    FASEB JOURNAL Volume: 16 Page(s): A843 - A843
    03/22/2002 Authors: Li CL; Klein JD; Wang WD; Knepper MA; Nielsen S; Sands JM; Frokiaer J
  • Aldosterone decreases the abundance of the UT-A1 urea transporter in the rat inner medulla.
    FASEB JOURNAL Volume: 16 Page(s): A890 - A890
    03/22/2002 Authors: Luo XH; Klein JD; Reyes MI; Sands JM
  • Renal UT-A mRNA expression in metabolic acidosis.
    FASEB JOURNAL Volume: 16 Page(s): A52 - A52
    03/20/2002 Authors: Bagnasco SM; Klaavuniemi T; Vikulina T; Deel MJ; Sands JM; Klein JD
  • The urine concentrating defect in ACE.2 mice results from alterations in solute transport.
    FASEB JOURNAL Volume: 16 Page(s): A51 - A51
    03/20/2002 Authors: Klein JD; Le Quach D; Cole JM; Disher K; Mongiu A; Bernstein KE; Sands JM
  • Acidosis mediates the upregulation of UT-A protein in livers from uremic rats.
    J Am Soc Nephrol Volume: 13 Page(s): 581 - 587
    03/01/2002 Authors: Klein JD; Rouillard P; Roberts BR; Sands JM
  • Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats.
    Kidney Int Volume: 61 Page(s): 995 - 1002
    03/01/2002 Authors: Klein JD; Gunn RB; Roberts BR; Sands JM
  • Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA.
    Am J Physiol Renal Physiol Volume: 282 Page(s): F85 - F90
    01/01/2002 Authors: Zhang C; Sands JM; Klein JD
  • Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism.
    Am J Physiol Cell Physiol Volume: 281 Page(s): C1948 - C1953
    12/01/2001 Authors: Jiang G; Klein JD; O'Neill WC
  • Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues.
    Am J Physiol Cell Physiol Volume: 281 Page(s): C1318 - C1325
    10/01/2001 Authors: Timmer RT; Klein JD; Bagnasco SM; Doran JJ; Verlander JW; Gunn RB; Sands JM
  • UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure.
    Circ Res Volume: 89 Page(s): 139 - 145
    07/20/2001 Authors: Duchesne R; Klein JD; Velotta JB; Doran JJ; Rouillard P; Roberts BR; McDonough AA; Sands JM
  • 97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.
    Am J Physiol Renal Physiol Volume: 281 Page(s): F133 - F143
    07/01/2001 Authors: Bradford AD; Terris JM; Ecelbarger CA; Klein JD; Sands JM; Chou CL; Knepper MA
  • Phosphorylation acutely regulates UT-A1 urea transporter activity in both rat tubules and cultured cells.
    FASEB JOURNAL Volume: 15 Page(s): A853 - A853
    03/08/2001 Authors: Klein JD; Froehlich O; Zhang C; Timmer RT; Gunn RB; Sands JM
  • Cloning and characterization of the human UT-A1 area transporter.
    FASEB JOURNAL Volume: 15 Page(s): A852 - A852
    03/08/2001 Authors: Bagnasco SM; Janech MJ; Karakashian A; Peng T; Klein JD
  • UT-A1 urea transporter regulation in lithium-treated rats.
    FASEB JOURNAL Volume: 15 Page(s): A852 - A852
    03/08/2001 Authors: Roberts BR; Klein JD; Gunn RB; Sands JM
  • Growth factors increase cell volume through a novel Cl-dependent activation of the Na-K-2Cl cotransporter NKCC1
    FASEB JOURNAL Volume: 15 Page(s): A441 - A441
    03/07/2001 Authors: O'Neill C; Jiang G; Klein JD
  • Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs.
    Am J Physiol Renal Physiol Volume: 279 Page(s): F835 - F840
    11/01/2000 Authors: Kato A; Klein JD; Zhang C; Sands JM
  • Glucocorticoids alter UT-A urea transporter protein abundances in the kidney.
    FASEB JOURNAL Volume: 14 Page(s): A347 - A347
    03/15/2000 Authors: Klein JD; Rouillard P; Bailey JL; Sands JM
  • Differential response of UT-A glycoproteins to acidosis.
    FASEB JOURNAL Volume: 14 Page(s): A347 - A347
    03/15/2000 Authors: Klein JD; Rouillard P; Duchesne R; Sands JM
  • Glucocorticoids alter UT-A urea transporter protein abundances in the kidney.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 48 Page(s): 192A - 192A
    03/01/2000 Authors: Klein JD; Rouillard P; Bailey JL; Sands JM
  • Differential response of UT-A glycoproteins to acidosis.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 48 Page(s): 192A - 192A
    03/01/2000 Authors: Klein JD; Rouillard P; Duchesne R; Sands JM
  • Effect of age and testosterone on the vasopressin and aquaporin responses to dehydration in Fischer 344/Brown-Norway F1 rats.
    J Gerontol A Biol Sci Med Sci Volume: 55 Page(s): B26 - B34
    01/01/2000 Authors: Catudioc-Vallero J; Sands JM; Klein JD; Sidorowicz HE; Sladek CD
  • UT-A urea transporter protein expressed in liver: upregulation by uremia.
    J Am Soc Nephrol Volume: 10 Page(s): 2076 - 2083
    10/01/1999 Authors: Klein JD; Timmer RT; Rouillard P; Bailey JL; Sands JM
  • JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro.
    Am J Physiol Volume: 277 Page(s): C425 - C431
    09/01/1999 Authors: Klein JD; Lamitina ST; O'Neill WC
  • Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms.
    Biochem Biophys Res Commun Volume: 260 Page(s): 619 - 625
    07/14/1999 Authors: Someren JS; Faber LE; Klein JD; Tumlin JA
  • Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta.
    Am J Physiol Volume: 276 Page(s): C1383 - C1390
    06/01/1999 Authors: Akar F; Skinner E; Klein JD; Jena M; Paul RJ; O'Neill WC
  • The erythrocyte urea transporter UT-B protein is expressed in rat kidney, liver, and heart.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 47 Page(s): 211A - 211A
    04/01/1999 Authors: Timmer RT; Verlander JW; Bagnasco SM; Rouillard P; Klein JD; Stockman B; Sands JM; Gunn RB
  • UT-A urea transporter proteins in rat heart: Regulation by uremia and angiotensin II.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 47 Page(s): 187A - 187A
    04/01/1999 Authors: Duchesne R; Klein JD; Rouillard P; Bailey JL; Lea JP; Sands JM
  • Volume sensitive phosphorylation of NKCC1 in vitro by terminal c-jun kinase.
    FASEB JOURNAL Volume: 13 Page(s): A711 - A711
    03/15/1999 Authors: Klein JD; Lamitina ST; O'Neill WC
  • UT-A urea transporter proteins in rat heart: Regulation by uremia and angiotensin II.
    FASEB JOURNAL Volume: 13 Page(s): A392 - A392
    03/12/1999 Authors: Duchesne R; Klein JD; Rouillard P; Bailey JL; Lea JP; Sands JM
  • The erythrocyte urea transporter UT-B protein is expressed in rat kidney, liver, and heart
    FASEB JOURNAL Volume: 13 Page(s): A391 - A391
    03/12/1999 Authors: Timmer RT; Verlander JW; Bagnasco SM; Rouillard P; Klein JD; Stockman B; Sands JM; Gunn RB
  • Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4.
    J Am Soc Nephrol Volume: 10 Page(s): 230 - 237
    02/01/1999 Authors: Karakashian A; Timmer RT; Klein JD; Gunn RB; Sands JM; Bagnasco SM
  • Abundance of UT-A urea transporter protein isoforms is altered in uremic rats.
    FASEB JOURNAL Volume: 12 Page(s): A331 - A331
    03/17/1998 Authors: Sands JM; Rouillard P; Bailey JL; Klein JD
  • Two isoforms of the UT-A urea transporter are expressed in liver.
    FASEB JOURNAL Volume: 12 Page(s): A423 - A423
    03/17/1998 Authors: Klein JD; Rouillard P; Sands JM
  • Effect of age and testosterone on the vasopressin response to dehydration in F344BNF1 male rats.
    Adv Exp Med Biol Volume: 449 Page(s): 183 - 185
    01/01/1998 Authors: Catudioc-Vallero J; Sands JM; Sidorowicz HE; Klein JD; Sladek CD
  • Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.
    Am J Physiol Volume: 273 Page(s): F949 - F953
    12/01/1997 Authors: Klein JD; Price SR; Bailey JL; Jacobs JD; Sands JM
  • Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.
    Am J Physiol Renal Physiol Volume: 273 Page(s): F949 - F953
    12/01/1997 Authors: Klein JD; Price SR; Bailey JL; Jacobs JD; Sands JM
  • Heterologous expression of the 2.9 and 4.0 kb isoforms of the rat renal urea transporter.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A0123 - A0123
    09/01/1997 Authors: Timmer RT; Bagnasco SM; Karakashian A; Klein JD; Sands JM; Gunn RB
  • Nitric oxide inhibits Na-K-2Cl cotransporter activity and phosphorylation in vascular smooth muscle via a cGMP-independent pathway.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A1526 - A1526
    09/01/1997 Authors: Jena M; Klein JD; ONeill WC
  • Protein kinases that phosphorylate the Na-K-2Cl cotransporter.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A0173 - A0173
    09/01/1997 Authors: Klein JD; Lamitina ST; ONeill WC
  • The vasopressin-regulated urea transporter is phosphorylated in rat inner medulla.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A0094 - A0094
    09/01/1997 Authors: Klein JD; Rouillard P; Kato A; Sands JM
  • Identification of two new mRNA isoforms of the rat renal urea transporter (UT-A) gene.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 8 Page(s): A0070 - A0070
    09/01/1997 Authors: Bagnasco SM; Karakashian A; Timmer RT; Klein JD; Sands JM
  • Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.
    J Am Soc Nephrol Volume: 8 Page(s): 517 - 523
    04/01/1997 Authors: Naruse M; Klein JD; Ashkar ZM; Jacobs JD; Sands JM
  • Heterologous expression and characterization of the 2.9 KB isoform of the rat renal urea transporter.
    BIOPHYSICAL JOURNAL Volume: 72 Page(s): TH384 - TH384
    02/01/1997 Authors: Timmer RT; Gunn RB; Froehlich O; Bagnasco SM; Klein JD; Sands JM
  • Rat facilitated urea transporter protein is decreased in the inner medullary tip of diabetic rats.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 7 Page(s): A0102 - A0102
    09/01/1996 Authors: Klein JD; Price SR; Jacobs JD; Sands JM
  • Glucocorticoids regulate the facilitated urea transporter protein and urea transport in rat terminal IMCDs.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 7 Page(s): A0112 - A0112
    09/01/1996 Authors: Naruse M; Klein JD; Jacobs JD; Sands JM
  • Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet.
    J Clin Invest Volume: 97 Page(s): 2807 - 2814
    06/15/1996 Authors: Sands JM; Naruse M; Jacobs JD; Wilcox JN; Klein JD
  • Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport.
    Am J Physiol Volume: 269 Page(s): C1524 - C1531
    12/01/1995 Authors: Klein JD; O'Neill WC
  • EVIDENCE THAT CHANGES IN AQUAPORIN-2 PROTEIN MAY CONTRIBUTE TO THE URINE CONCENTRATING DEFECT IN RATS FED A LOW-PROTEIN DIET
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 6 Page(s): 329 - 329
    09/01/1995 Authors: SANDS JM; JACOBS JD; WILCOX JN; KLEIN JD
  • PHOSPHORYLATION OF THE NA-K-2CL COTRANSPORT PROTEIN IN AORTIC ENDOTHELIAL-CELLS - CORRELATION WITH COTRANSPORT ACTIVITY
    FASEB JOURNAL Volume: 9 Page(s): A304 - A304
    03/09/1995 Authors: KLEIN JD; STEINBERG D; ONEILL WC
  • The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases.
    Biochem Biophys Res Commun Volume: 200 Page(s): 260 - 267
    04/15/1994 Authors: Paxton WG; Marrero MB; Klein JD; Delafontaine P; Berk BC; Bernstein KE
  • THE ANGIOTENSIN-II AT(1) RECEPTOR IS SERINE AND TYROSINE-PHOSPHORYLATED AND CAN SERVE AS A SUBSTRATE FOR THE SRC FAMILY OF TYROSINE KINASES
    Volume: 8 Page(s): A89 - A89
    03/01/1994 Authors: PAXTON WG; MARRERO MB; KLEIN JD; DELAFONTAINE P; BERK BC; BERNSTEIN KE
  • Regulation by cell volume of Na(+)-K(+)-2Cl- cotransport in vascular endothelial cells: role of protein phosphorylation.
    J Membr Biol Volume: 132 Page(s): 243 - 252
    03/01/1993 Authors: Klein JD; Perry PB; O'Neill WC
  • REGULATION OF VASCULAR ENDOTHELIAL MORPHOLOGY BY PROTEIN-PHOSPHORYLATION
    FASEB JOURNAL Volume: 7 Page(s): A786 - A786
    02/23/1993 Authors: KLEIN JD; ONEILL WC
  • Purification and partial characterization of transglutaminase from Physarum polycephalum.
    J Bacteriol Volume: 174 Page(s): 2599 - 2605
    04/01/1992 Authors: Klein JD; Guzman E; Kuehn GD
  • Regulation of vascular endothelial cell volume by Na-K-2Cl cotransport.
    Am J Physiol Volume: 262 Page(s): C436 - C444
    02/01/1992 Authors: O'Neill WC; Klein JD
  • REGULATION OF VASCULAR ENDOTHELIAL-CELL VOLUME BY NA-K2CL COTRANSPORT
    FASEB JOURNAL Volume: 5 Page(s): A1472 - A1472
    03/19/1991 Authors: ONEILL WC; KLEIN JD; PERRY PB
  • Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells.
    J Biol Chem Volume: 265 Page(s): 22238 - 22242
    12/25/1990 Authors: Klein JD; O'Neill WC
  • Regulation and action of insulin-like growth factors at the cellular level.
    Proc Nutr Soc Volume: 49 Page(s): 451 - 458
    10/01/1990 Authors: Phillips LS; Harp JB; Goldstein S; Klein J; Pao CI
  • MECHANISM OF STIMULATION OF NA-K-2CL COTRANSPORT BY BRADYKININ IN AORTIC ENDOTHELIAL-CELLS
    CLINICAL RESEARCH Volume: 38 Page(s): A442 - A442
    04/01/1990 Authors: KLEIN JD; ONEILL WC
  • UREMIC SERUM GROWTH INHIBITOR
    CLINICAL RESEARCH Volume: 38 Page(s): A33 - A33
    01/01/1990 Authors: PHILLIPS LS; GOLDSTEIN S; KLEIN JD; SULINSKI CM; ELKEBBI IM; ZIEMER DC; POLLET RJ; STULTS J
  • Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).
    Biochemistry Volume: 25 Page(s): 4175 - 4179
    07/29/1986 Authors: Klein JD; Walker FJ
  • PURIFICATION OF A PROTEIN-C ACTIVATOR FROM THE VENOM OF THE COPPERHEAD SNAKE (AKISTRODON-CONTORTRIX-CONTORTRIX)
    Volume: 45 Page(s): 1493 - 1493
    05/01/1986 Authors: KLEIN J; WALKER FJ
  • Membrane-bound H-2 and H-y antigens move independently of each other.
    Nature Volume: 270 Page(s): 352 - 354
    11/24/1977 Authors: Geib R; Goldberg EH; Klein J
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