Publications

• Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer.
  Nat Commun Volume: 16 Page(s): 2324
  03/08/2025 Authors: Shu C; Li J; Rui J; Fan D; Niu Q; Bai R; Cicka D; Doyle S; Wahafu A; Zheng X
• Decoding the functional impact of the cancer genome through protein-protein interactions.
  Nat Rev Cancer Volume: 25 Page(s): 189 - 208
  03/01/2025 Authors: Fu H; Mo X; Ivanov AA
• Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook.
  STAR Protoc Volume: 5 Page(s): 103441
  12/20/2024 Authors: Chen H; Revennaugh B; Fu H; Ivanov AA
• Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.
  Cancer Res Volume: 84 Page(s): 3761 - 3771
  11/15/2024 Authors: Koo J; Seong C-S; Parker RE; Herrera A; Dwivedi B; Arthur RA; Dinasarapu AR; Johnston HR; Claussen H; Tucker-Burden C
• AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions.
  iScience Volume: 27 Page(s): 110035
  06/21/2024 Authors: Chen H; Revennaugh B; Fu H; Ivanov AA
• A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4-SMAD3-DNA complex.
  J Mol Cell Biol Volume: 15
  04/10/2024 Authors: Ouyang W; Li Q; Niu Q; Qui M; Fu H; Du Y; Mo X
• Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
  J Biol Chem Volume: 299 Page(s): 105382
  12/01/2023 Authors: Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV
• Fused Tetrahydroquinolines Are Interfering with Your Assay.
  J Med Chem Volume: 66 Page(s): 14434 - 14446
  11/09/2023 Authors: Bashore FM; Annor-Gyamfi J; Du Y; Katis V; Nwogbo F; Flax RG; Frye SV; Pearce KH; Fu H; Willson TM
• A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
  ACS Med Chem Lett Volume: 14 Page(s): 1338 - 1343
  10/12/2023 Authors: Rab A; Yang X; Tracy WF; Hong JS; Joshi D; Manfredi C; Ponnaluri SS; Kolykhalov AA; Qui M; Fu H
• Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models.
  Br J Cancer Volume: 129 Page(s): 884 - 894
  09/01/2023 Authors: Li X; Chen Y; Bai L; Zhao R; Wu Y; Xie Z-R; Wu JM; Bowen NJ; Danaher A; Cook N
• Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia.
  J Control Release Volume: 361 Page(s): 470 - 482
  09/01/2023 Authors: Kelvin JM; Chimenti ML; Zhang DY; Williams EK; Moore SG; Humber GM; Baxter TA; Birnbaum LA; Qui M; Zecca H
• Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML.
  Pharm Res Volume: 40 Page(s): 2133 - 2146
  09/01/2023 Authors: Kelvin JM; Jain J; Thapa A; Qui M; Birnbaum LA; Moore SG; Zecca H; Summers RJ; Switchenko JM; Costanza E
• TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
  J Mol Cell Biol Volume: 15
  08/03/2023 Authors: Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y
• Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models.
  Transl Oncol Volume: 34 Page(s): 101707
  08/01/2023 Authors: Bai L; Li X; Yang Y; Zhao R; White EZ; Danaher A; Bowen NJ; Hinton CV; Cook N; Li D
• Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
  bioRxiv
  07/29/2023 Authors: Bashore FM; Katis VL; Du Y; Sikdar A; Wang D; Bradshaw WJ; Rygiel KA; Leisner TM; Chalk R; Mishra S
• Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.
  bioRxiv
  06/14/2023 Authors: Koo J; Seong C-S; Parker RE; Dwivedi B; Arthur RA; Dinasarapu AR; Johnston HR; Claussen H; Tucker-Burden C; Ramalingam SS
• Cyclosporines Antagonize the Antiviral Activity of IFITMProteins by Redistributing Them toward the Golgi Apparatus.
  Biomolecules Volume: 13
  06/03/2023 Authors: Prikryl D; Marin M; Desai TM; Du Y; Fu H; Melikyan GB
• Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.
  bioRxiv
  05/22/2023 Authors: Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV
• Ligand dependent interaction between PC-TP and PPAR mitigates diet-induced hepatic steatosis in male mice.
  Nat Commun Volume: 14 Page(s): 2748
  05/12/2023 Authors: Druzak SA; Tardelli M; Mays SG; El Bejjani M; Mo X; Maner-Smith KM; Bowen T; Cato ML; Tillman MC; Sugiyama A
• Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML.
  bioRxiv
  03/15/2023 Authors: Kelvin JM; Jain J; Thapa A; Qui M; Birnbaum LA; Moore SG; Zecca H; Summers RJ; Costanza E; Uricoli B
• Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.
  bioRxiv
  01/27/2023 Authors: Seong C-S; Huang C; Boese AC; Hou Y; Koo J; Mouw JK; Rupji M; Joseph G; Johnston HR; Claussen H
• Open drug discovery in Alzheimer's disease.
  Alzheimers Dement (N Y) Volume: 9 Page(s): e12394
  01/01/2023 Authors: Axtman AD; Brennan PE; Frappier-Brinton T; Betarbet R; Carter GW; Fu H; Gileadi O; Greenwood AK; Leal K; Longo FM
• EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer.
  Cell Rep Volume: 41 Page(s): 111827
  12/13/2022 Authors: Kang J; Chun J; Hwang JS; Pan C; Li J; Boese AC; Young I; Malin CM; Kang Y; Gibbons DL
• High-throughput screening strategies for space-based radiation countermeasure discovery.
  Life Sci Space Res (Amst) Volume: 35 Page(s): 88 - 104
  11/01/2022 Authors: Putt KS; Du Y; Fu H; Zhang Z-Y
• Correction for Puckett et al., "Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IB Kinase Cascade".
  Mol Cell Biol Volume: 42 Page(s): e0028222
  10/20/2022 Authors: Puckett MC; Goldman EH; Cockrell LM; Huang B; Kasinski AL; Du Y; Wang C-Y; Lin A; Ichijo H; Khuri F
• Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.
  Acta Pharmacol Sin Volume: 43 Page(s): 2419 - 2428
  09/01/2022 Authors: Shu C; Zheng X; Wuhafu A; Cicka D; Doyle S; Niu Q; Fan D; Qian K; Ivanov AA; Du Y
• Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
  Cell Volume: 185 Page(s): 1974 - 1985.e12
  05/26/2022 Authors: Mo X; Niu Q; Ivanov AA; Tsang YH; Tang C; Shu C; Li Q; Qian K; Wahafu A; Doyle SP
• A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators.
  STAR Protoc Volume: 2 Page(s): 100804
  09/17/2021 Authors: Tang C; Niu Q; Cicka D; Du Y; Mo X; Fu H
• Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
  Bioorg Med Chem Volume: 45 Page(s): 116324
  09/01/2021 Authors: Yang X; Fan D; Troha AH; Ahn HM; Qian K; Liang B; Du Y; Fu H; Ivanov AA
• A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.
  Cancer Discov Volume: 11 Page(s): 1562 - 1581
  06/01/2021 Authors: Lo Y-H; Kolahi KS; Du Y; Chang C-Y; Krokhotin A; Nair A; Sobba WD; Karlsson K; Jones SJ; Longacre TA
• Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF- signaling.
  Cell Chem Biol Volume: 28 Page(s): 636 - 647.e5
  05/20/2021 Authors: Tang C; Mo X; Niu Q; Wahafu A; Yang X; Qui M; Ivanov AA; Du Y; Fu H
• Functional and molecular effects of TNF- on human iPSC-derived cardiomyocytes.
  Stem Cell Res Volume: 52 Page(s): 102218
  04/01/2021 Authors: Saraf A; Rampoldi A; Chao M; Li D; Armand L; Hwang H; Liu R; Jha R; Fu H; Maxwell JT
• An expanded universe of cancer targets.
  Cell Volume: 184 Page(s): 1142 - 1155
  03/04/2021 Authors: Hahn WC; Bader JS; Braun TP; Califano A; Clemons PA; Druker BJ; Ewald AJ; Fu H; Jagu S; Kemp CJ
• YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell-Inflamed Phenotype.
  J Thorac Oncol Volume: 16 Page(s): 464 - 476
  03/01/2021 Authors: Owonikoko TK; Dwivedi B; Chen Z; Zhang C; Barwick B; Ernani V; Zhang G; Gilbert-Ross M; Carlisle J; Khuri FR
• Expression and purification of active human kinases using Pichia pastoris as a general-purpose host.
  Protein Expr Purif Volume: 179 Page(s): 105780
  03/01/2021 Authors: Abdel Aziz MH; Fan Y; Liu L; Moasser MM; Fu H; Jura N; Arkin MR
• Differential Expression of CD44 Variants in Normal and AD Brain
  
  01/01/2021 Authors: Johnson E; Qian K; Betarbet R; Commander R; Gileadi O; Fu H; Levey A
• Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer.
  Theranostics Volume: 11 Page(s): 6873 - 6890
  01/01/2021 Authors: Li X; Gera L; Zhang S; Chen Y; Lou L; Wilson LM; Xie Z-R; Sautto G; Liu D; Danaher A
• High Throughput Screening Methods for PPI Inhibitor Discovery
  Volume: 78 Page(s): 49 - 86
  01/01/2021 Authors: Doyle SP; Mo X; Qian K; Cicka DN; Niu Q; Fu H
• Protein-Protein Interaction Regulators Preface
  Volume: 78 Page(s): VII - IX
  01/01/2021 Authors: Roy S; Fu H
• Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells.
  Stem Cell Res Ther Volume: 11 Page(s): 470
  11/05/2020 Authors: Liu R; Li D; Sun F; Rampoldi A; Maxwell JT; Wu R; Fischbach P; Castellino SM; Du Y; Fu H
• Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.
  J Hematol Oncol Volume: 13 Page(s): 141
  10/21/2020 Authors: Lei K; Gu X; Alvarado AG; Du Y; Luo S; Ahn EH; Kang SS; Ji B; Liu X; Mao H
• High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients.
  J Transl Med Volume: 18 Page(s): 334
  09/01/2020 Authors: Yang X; Amgad M; Cooper LAD; Du Y; Fu H; Ivanov AA
• Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
  J Mol Cell Biol Volume: 12 Page(s): 630 - 643
  08/01/2020 Authors: Du Y; Li X; Niu Q; Mo X; Qui M; Ma T; Kuo CJ; Fu H
• NSD3S stabilizes MYC through hindering its interaction with FBXW7.
  J Mol Cell Biol Volume: 12 Page(s): 438 - 447
  07/03/2020 Authors: Gonzalez-Pecchi V; Kwan AK; Doyle S; Ivanov AA; Du Y; Fu H
• 14-3-3, a novel regulator of the large-conductance Ca2+-activated K+ channel.
  Am J Physiol Renal Physiol Volume: 319 Page(s): F52 - F62
  07/01/2020 Authors: Chen S; Feng X; Chen X; Zhuang Z; Xiao J; Fu H; Klein JD; Wang XH; Hoover RS; Eaton DC
• Human beige adipocytes for drug discovery and cell therapy in metabolic diseases.
  Nat Commun Volume: 11 Page(s): 2758
  06/02/2020 Authors: Singh AM; Zhang L; Avery J; Yin A; Du Y; Wang H; Li Z; Fu H; Yin H; Dalton S
• Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.
  Cancer Gene Ther Volume: 27 Page(s): 399 - 411
  06/01/2020 Authors: Yang X; Cao W; Wang X; Zhang X; Zhang W; Li Z; Fu H
• Online informatics resources to facilitate cancer target and chemical probe discovery.
  RSC Med Chem Volume: 11 Page(s): 611 - 624
  06/01/2020 Authors: Yang X; Fu H; Ivanov AA
• Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.
  Nat Commun Volume: 11 Page(s): 1533
  03/24/2020 Authors: Commander R; Wei C; Sharma A; Mouw JK; Burton LJ; Summerbell E; Mahboubi D; Peterson RJ; Konen J; Zhou W
• Acetylation regulates ribonucleotide reductase activity and cancer cell growth.
  Nat Commun Volume: 10 Page(s): 3213
  07/19/2019 Authors: Chen G; Luo Y; Warncke K; Sun Y; Yu DS; Fu H; Behera M; Ramalingam SS; Doetsch PW; Duong DM
• Discovery and targeting MKK3-MYC protein-protein interaction for therapeutic interrogation in cancer
  Volume: 79
  07/01/2019 Authors: Yang X; Du Y; Fu H; Ivanov AA
• BRAF-V600E DEGRADATION AS A THERAPEUTIC STRATEGY IN BRAF-V600E MUTANT GLIOMAS
  Volume: 21 Page(s): 117 - 117
  04/01/2019 Authors: Zhao G; Muldoon D; Mo X; Tang C; Fu H; Gustafson WC; Weiss WA; Nicolaides T
• HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
  Cell Chem Biol Volume: 26 Page(s): 331 - 339.e3
  03/21/2019 Authors: Mo X; Tang C; Niu Q; Ma T; Du Y; Fu H
• Identification of higenamine as a novel 1 -adrenergic receptor antagonist.
  Phytother Res Volume: 33 Page(s): 708 - 717
  03/01/2019 Authors: Zhang N; Qu K; Wang M; Yin Q; Wang W; Xue L; Fu H; Zhu H; Li Z
• Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
  J Med Chem Volume: 61 Page(s): 10588 - 10601
  12/13/2018 Authors: Horton JR; Woodcock CB; Chen Q; Liu X; Zhang X; Shanks J; Rai G; Mott BT; Jansen DJ; Kales SC
• Polyethylene-glycol-coated gold nanoparticles improve cardiac function after myocardial infarction in mice.
  Can J Physiol Pharmacol Volume: 96 Page(s): 1318 - 1327
  12/01/2018 Authors: Tian A; Yang C; Zhu B; Wang W; Liu K; Jiang Y; Qiao Y; Fu H; Li Z
• Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
  J Mol Cell Biol Volume: 10 Page(s): 549 - 558
  12/01/2018 Authors: Rusnak L; Tang C; Qi Q; Mo X; Fu H
• Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells invitro and invivo by inhibiting the EphA2/Akt signaling pathway.
  Oncol Rep Volume: 40 Page(s): 1339 - 1347
  09/01/2018 Authors: Chen M; Hu C; Guo Y; Jiang R; Jiang H; Zhou Y; Fu H; Wu M; Zhang X
• Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer.
  Mol Cancer Ther Volume: 17 Page(s): 1859 - 1870
  09/01/2018 Authors: Yang Y; Mamouni K; Li X; Chen Y; Kavuri S; Du Y; Fu H; Kucuk O; Wu D
• Potent zwitterionic anticancer agent: Selective killing of cancer by targeting cancer redox metabolism
  Volume: 256
  08/19/2018 Authors: Song J; Mi J; Jin L; Liang B; Jones D; Fu H; Hill C; Nie S
• In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
  Nat Commun Volume: 9 Page(s): 2732
  07/16/2018 Authors: Grzeskowiak CL; Kundu ST; Mo X; Ivanov AA; Zagorodna O; Lu H; Chapple RH; Tsang YH; Moreno D; Mosqueda M
• Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening.
  Sci Rep Volume: 8 Page(s): 10210
  07/05/2018 Authors: Mady ASA; Liao C; Bajwa N; Kump KJ; Abulwerdi FA; Lev KL; Miao L; Grigsby SM; Perdih A; Stuckey JA
• BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.
  Cell Death Dis Volume: 9 Page(s): 458
  05/01/2018 Authors: Sime W; Niu Q; Abassi Y; Masoumi KC; Zarrizi R; Khler JB; Kjellstrm S; Lasorsa VA; Capasso M; Fu H
• Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
  ACS Chem Biol Volume: 13 Page(s): 933 - 941
  04/20/2018 Authors: Huard DJE; Crowley VM; Du Y; Cordova RA; Sun Z; Tomlin MO; Dickey CA; Koren J; Blair L; Fu H
• Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
  J Med Chem Volume: 61 Page(s): 3193 - 3208
  04/12/2018 Authors: Horton JR; Liu X; Wu L; Zhang K; Shanks J; Zhang X; Rai G; Mott BT; Jansen DJ; Kales SC
• The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.
  Bioinformatics Volume: 34 Page(s): 1183 - 1191
  04/01/2018 Authors: Ivanov AA; Revennaugh B; Rusnak L; Gonzalez-Pecchi V; Mo X; Johns MA; Du Y; Cooper LAD; Moreno CS; Khuri FR
• 14-3-3 binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.
  Leukemia Volume: 32 Page(s): 744 - 751
  03/01/2018 Authors: Gu Y; Xu K; Torre C; Samur M; Barwick BG; Rupji M; Arora J; Neri P; Kaufman J; Nooka A
• Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
  Nat Biotechnol Volume: 36 Page(s): 170 - 178
  02/01/2018 Authors: Boettcher M; Tian R; Blau JA; Markegard E; Wagner RT; Wu D; Mo X; Biton A; Zaitlen N; Fu H
• Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.
  Assay Drug Dev Technol Volume: 16 Page(s): 96 - 106
  01/01/2018 Authors: Xiong J; Pecchi VG; Qui M; Ivanov AA; Mo X; Niu Q; Chen X; Fu H; Du Y
• Regulation of ASK1 signaling by scaffold and adaptor proteins.
  Adv Biol Regul Volume: 66 Page(s): 23 - 30
  12/01/2017 Authors: Rusnak L; Fu H
• OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.
  Oncogene Volume: 36 Page(s): 5852 - 5860
  10/19/2017 Authors: Ivanov AA; Gonzalez-Pecchi V; Khuri LF; Niu Q; Wang Y; Xu Y; Bai Y; Mo X; Prochownik EV; Johns MA
• PRAS40 promotes NF-B transcriptional activity through association with p65.
  Oncogenesis Volume: 6 Page(s): e381
  09/25/2017 Authors: Zhu G; Qi Q; Havel JJ; Li Z; Du Y; Zhang X; Fu H
• Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
  J Med Chem Volume: 60 Page(s): 7244 - 7255
  09/14/2017 Authors: Qi Q; Obianyo O; Du Y; Fu H; Li S; Ye K
• Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.
  Oncogene Volume: 36 Page(s): 4562 - 4572
  08/10/2017 Authors: Qi Q; Kang SS; Zhang S; Pham C; Fu H; Brat DJ; Ye K
• Modulation of Bax and mTOR for cancer therapeutics
  Volume: 77
  07/01/2017 Authors: Li R; Ding C; Zhang J; Xie M; Park D; Ding Y; Chen G; Zhang G; Gilbert-Ross M; Zhou W
• Modulation of Bax and mTOR for Cancer Therapeutics.
  Cancer Res Volume: 77 Page(s): 3001 - 3012
  06/01/2017 Authors: Li R; Ding C; Zhang J; Xie M; Park D; Ding Y; Chen G; Zhang G; Gilbert-Ross M; Zhou W
• Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling.
  Oncotarget Volume: 8 Page(s): 28359 - 28372
  04/25/2017 Authors: Umstead M; Xiong J; Qi Q; Du Y; Fu H
• Corrigendum: The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
  Nat Commun Volume: 8 Page(s): 15350
  04/18/2017 Authors: Li Z; Ivanov AA; Su R; Gonzalez-Pecchi V; Qi Q; Liu S; Webber P; McMillan E; Rusnak L; Pham C
• AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay.
  Mol Pharmacol Volume: 91 Page(s): 339 - 347
  04/01/2017 Authors: Mo X; Qi Q; Ivanov AA; Niu Q; Luo Y; Havel J; Goetze R; Bell S; Moreno CS; Cooper LAD
• Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
  Nat Commun Volume: 8 Page(s): 14740
  03/27/2017 Authors: Zhang Z; Obianyo O; Dall E; Du Y; Fu H; Liu X; Kang SS; Song M; Yu S-P; Cabrele C
• Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.
  JCI Insight Volume: 2 Page(s): e90487
  03/09/2017 Authors: Gilbert-Ross M; Konen J; Koo J; Shupe J; Robinson BS; Wiles WG; Huang C; Martin WD; Behera M; Smith GH
• The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
  Nat Commun Volume: 8 Page(s): 14356
  02/16/2017 Authors: Li Z; Ivanov AA; Su R; Gonzalez-Pecchi V; Qi Q; Liu S; Webber P; McMillan E; Rusnak L; Pham C
• Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.
  J Cancer Volume: 8 Page(s): 2449 - 2455
  01/01/2017 Authors: Xiong F; Jiang M; Chen M; Wang X; Zhang S; Zhou J; Li K; Sheng Y; Yin L; Tang Y
• Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.
  Assay Drug Dev Technol Volume: 15 Page(s): 53 - 63
  01/01/2017 Authors: Giroud C; Du Y; Marin M; Min Q; Jui NT; Fu H; Melikyan GB
• MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.
  PLoS One Volume: 12 Page(s): e0170339
  01/01/2017 Authors: Harati S; Cooper LAD; Moran JD; Giuste FO; Du Y; Ivanov AA; Johns MA; Khuri FR; Fu H; Moreno CS
• Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.
  Cancer Cell Volume: 30 Page(s): 623 - 636
  10/10/2016 Authors: Gu L; Zhang H; Liu T; Zhou S; Du Y; Xiong J; Yi S; Qu C-K; Fu H; Zhou M
• Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance.
  Mol Cancer Res Volume: 14 Page(s): 675 - 682
  08/01/2016 Authors: Cancer Target Discovery and Development Network
• Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
  Cell Chem Biol Volume: 23 Page(s): 769 - 781
  07/21/2016 Authors: Horton JR; Liu X; Gale M; Wu L; Shanks JR; Zhang X; Webber PJ; Bell JSK; Kales SC; Mott BT
• Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells.
  Int J Oncol Volume: 49 Page(s): 316 - 324
  07/01/2016 Authors: Chen M; Guo Y; Zhao R; Wang X; Jiang M; Fu H; Zhang X
• Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma
  Volume: 76
  07/01/2016 Authors: Gilbert-Ross M; Konen J; Koo J; Shupe J; Sica GL; Chen Z; Robinson BS; Behera M; Rossi MR; Smith GH
• The regulation of pre-ribosomal RNA synthesis by LKB1
  Volume: 76
  07/01/2016 Authors: Jin R; Liu F; Liu X; Huang H; Wilkinson SC; Zhong D; Khuri FR; Fu H; Marcus AI; He Y
• Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.
  J Mol Cell Biol Volume: 8 Page(s): 271 - 281
  06/01/2016 Authors: Mo X-L; Luo Y; Ivanov AA; Su R; Havel JJ; Li Z; Khuri FR; Du Y; Fu H
• LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.
  Mol Biol Cell Volume: 27 Page(s): 1069 - 1084
  04/01/2016 Authors: Konen J; Wilkinson S; Lee B; Fu H; Zhou W; Jiang Y; Marcus AI
• An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma
  Volume: 76
  04/01/2016 Authors: Gilbert-Ross M; Konen J; Shupe J; Koo J; Sica GL; Ramalingam SS; Fu H; Khuri FR; Zhou W; Marcus AI
• Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
  J Biol Chem Volume: 291 Page(s): 2631 - 2646
  02/05/2016 Authors: Horton JR; Engstrom A; Zoeller EL; Liu X; Shanks JR; Zhang X; Johns MA; Vertino PM; Fu H; Cheng X
• LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions.
  Oncotarget Volume: 7 Page(s): 2519 - 2531
  01/19/2016 Authors: Liu F; Jin R; Liu X; Huang H; Wilkinson SC; Zhong D; Khuri FR; Fu H; Marcus A; He Y
• 2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.
  PLoS One Volume: 11 Page(s): e0168793
  01/01/2016 Authors: Sun L; Liu X; Fu H; Zhou W; Zhong D
• BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer Platform to Monitor Protein-Protein Interactions in Live Cells.
  Methods Mol Biol Volume: 1439 Page(s): 263 - 271
  01/01/2016 Authors: Mo X-L; Fu H
• Predicting the essentialities of protein-protein interactions in cancer
  CANCER RESEARCH Volume: 75
  11/15/2015 Authors: Cooper LAD; Moran JD; Li Z; Du Y; Harati S; Ivanov AA; Webber P; Havel JJ; Johns MA; Fu H
• Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor (FXR) in Stabilizing the Homodimerization of the Receptor.
  J Biol Chem Volume: 290 Page(s): 19888 - 19899
  08/07/2015 Authors: Xu X; Xu X; Liu P; Zhu Z-Y; Chen J; Fu H-A; Chen L-L; Hu L-H; Shen X
• Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.
  Am J Physiol Renal Physiol Volume: 309 Page(s): F71 - F78
  07/01/2015 Authors: Feng X; Li Z; Du Y; Fu H; Klein JD; Cai H; Sands JM; Chen G
• Interview with Haian Fu, PhD.
  Assay Drug Dev Technol Volume: 13 Page(s): 249 - 253
  06/01/2015 Authors: Fu H; Napper AD
• Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-B pathway.
  Int J Cancer Volume: 136 Page(s): 2341 - 2351
  05/15/2015 Authors: Ramachandiran S; Adon A; Guo X; Wang Y; Wang H; Chen Z; Kowalski J; Sunay UR; Young AN; Brown T
• Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3.
  Oncogene Volume: 34 Page(s): 2538 - 2545
  05/07/2015 Authors: Shi Z; Li Z; Li ZJ; Cheng K; Du Y; Fu H; Khuri FR
• A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer.
  Clin Cancer Res Volume: 21 Page(s): 1859 - 1868
  04/15/2015 Authors: Owonikoko TK; Ramalingam SS; Miller DL; Force SD; Sica GL; Mendel J; Chen Z; Rogatko A; Tighiouart M; Harvey RD
• High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.
  Assay Drug Dev Technol Volume: 13 Page(s): 155 - 166
  04/01/2015 Authors: Marin M; Du Y; Giroud C; Kim JH; Qui M; Fu H; Melikyan GB
• Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.
  Oncogene Volume: 34 Page(s): 1487 - 1498
  03/19/2015 Authors: Havel JJ; Li Z; Cheng D; Peng J; Fu H
• Glycyrrhetinic acid induces G1phase cell cycle arrest in human nonsmall cell lung cancer cells through endoplasmic reticulum stress pathway.
  Int J Oncol Volume: 46 Page(s): 981 - 988
  03/01/2015 Authors: Zhu J; Chen M; Chen N; Ma A; Zhu C; Zhao R; Jiang M; Zhou J; Ye L; Fu H
• Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.
  Mol Cell Volume: 57 Page(s): 721 - 734
  02/19/2015 Authors: Yang Q; Li W; She H; Dou J; Duong DM; Du Y; Yang S-H; Seyfried NT; Fu H; Gao G
• Cables1 complex couples survival signaling to the cell death machinery.
  Cancer Res Volume: 75 Page(s): 147 - 158
  01/01/2015 Authors: Shi Z; Park HR; Du Y; Li Z; Cheng K; Sun S-Y; Li Z; Fu H; Khuri FR
• Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways.
  J Cancer Volume: 6 Page(s): 623 - 631
  01/01/2015 Authors: Zhao R; Chen M; Jiang Z; Zhao F; Xi B; Zhang X; Fu H; Zhou K
• Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
  Oncoscience Volume: 2 Page(s): 765 - 776
  01/01/2015 Authors: Webber PJ; Park C; Qui M; Ramalingam SS; Khuri FR; Fu H; Du Y
• Protein-Protein Interactions Methods and Applications Second Edition Preface
  Volume: 1278 Page(s): V - VI
  01/01/2015 Authors: Meyerkord CL; Fu H
• Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.
  Drug Dev Res Volume: 75 Page(s): 455 - 462
  11/01/2014 Authors: Shi Z-H; Li N-G; Tang Y-P; Shi Q-P; Tang H; Li W; Zhang X; Fu H-A; Duan J-A
• Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer.
  Bioorg Med Chem Lett Volume: 24 Page(s): 4424 - 4427
  09/15/2014 Authors: Shi Z-H; Li N-G; Tang Y-P; Shi Q-P; Zhang W; Zhang P-X; Dong Z-X; Li W; Zhang X; Fu H-A
• Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells.
  J Med Chem Volume: 57 Page(s): 5904 - 5918
  07/24/2014 Authors: Tan K-L; Ali A; Du Y; Fu H; Jin H-X; Chin T-M; Khan M; Go M-L
• Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
  Oncotarget Volume: 5 Page(s): 3197 - 3209
  05/30/2014 Authors: Li Z; Park HR; Shi Z; Li Z; Pham CD; Du Y; Khuri FR; Zhang Y; Han Q; Fu H
• The Emory Chemical Biology Discovery Center: leveraging academic innovation to advance novel targets through HTS and beyond.
  Comb Chem High Throughput Screen Volume: 17 Page(s): 290 - 296
  03/01/2014 Authors: Johns MA; Meyerkord-Belton CL; Du Y; Fu H
• A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells.
  Integr Cancer Ther Volume: 13 Page(s): 152 - 160
  03/01/2014 Authors: Xiong F; Jiang M; Huang Z; Chen M; Chen K; Zhou J; Yin L; Tang Y; Wang M; Ye L
• Ligands for glaucoma-associated myocilin discovered by a generic binding assay.
  ACS Chem Biol Volume: 9 Page(s): 517 - 525
  02/21/2014 Authors: Orwig SD; Chi PV; Du Y; Hill SE; Cavitt MA; Suntharalingam A; Turnage KC; Dickey CA; France S; Fu H
• Transcriptional regulation of YWHAZ, the gene encoding 14-3-3.
  PLoS One Volume: 9 Page(s): e93480
  01/01/2014 Authors: Kasinski A; Dong X; Khuri FR; Boss J; Fu H
• Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog.
  PLoS One Volume: 9 Page(s): e107876
  01/01/2014 Authors: Zhou T; Ye L; Bai Y; Sun A; Cox B; Liu D; Li Y; Liotta D; Snyder JP; Fu H
• Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts.
  Curr Cancer Drug Targets Volume: 14 Page(s): 380 - 393
  01/01/2014 Authors: Zhu S; Moore TW; Morii N; Howard RB; Culver D; Arrendale RF; Reddy P; Evers TJ; Zhang H; Sica G
• Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma (vol 11, pg 4757, 2013)
  ORGANIC & BIOMOLECULAR CHEMISTRY Volume: 11 Page(s): 8511 - 8511
  12/28/2013 Authors: Liu K; Zhang D; Chojnacki J; Du Y; Wu J; Fu H; Grant S; Zhang S
• A PHASE IB PREOPERATIVE PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF EVEROLIMUS IN OPERABLE NON SMALL CELL LUNG CANCER
  JOURNAL OF THORACIC ONCOLOGY Volume: 8 Page(s): S628 - S629
  11/01/2013 Authors: Owonikoko TK; Miller DL; Force S; Sica G; Saba NF; Kono SA; Behera M; Lewis C; Chen Z; Pickens A
• Influence of spousal education on partner's self-rated health: cross-sectional study among 1382 married couples in Shanghai, China.
  Asia Pac J Public Health Volume: 25 Page(s): 398 - 408
  09/01/2013 Authors: Li Y; Fu H; Zhao F; Luo J; Kawachi I
• Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.
  Org Biomol Chem Volume: 11 Page(s): 4757 - 4763
  08/07/2013 Authors: Liu K; Zhang D; Chojnacki J; Du Y; Fu H; Grant S; Zhang S
• p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
  Mol Cell Biol Volume: 33 Page(s): 2574 - 2585
  07/01/2013 Authors: Jin L; Li D; Lee JS; Elf S; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J
• Targeting protein-protein interactions as an anticancer strategy.
  Trends Pharmacol Sci Volume: 34 Page(s): 393 - 400
  07/01/2013 Authors: Ivanov AA; Khuri FR; Fu H
• A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.
  Assay Drug Dev Technol Volume: 11 Page(s): 367 - 381
  07/01/2013 Authors: Du Y; Fu RW; Lou B; Zhao J; Qui M; Khuri FR; Fu H
• Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IB kinase cascade.
  Mol Cell Biol Volume: 33 Page(s): 2252 - 2259
  06/01/2013 Authors: Puckett MC; Goldman EH; Cockrell LM; Huang B; Kasinski AL; Du Y; Wang C-Y; Lin A; Ichijo H; Khuri F
• Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
  J Biol Chem Volume: 288 Page(s): 13215 - 13224
  05/10/2013 Authors: Li Y; Wang X; Yue P; Tao H; Ramalingam SS; Owonikoko TK; Deng X; Wang Y; Fu H; Khuri FR
• Identification of novel Mcl-1 inhibitors using integrated screening approach: combining high throughput and virtual screening.
  Volume: 73
  04/15/2013 Authors: Mady A; Liao C; Abulwerdi F; Shen C; Du Y; Stuckey J; Fu H; Nikolovska-Coleska Z
• Computational modeling reveals druggable cavities at the MKK3 and p38 protein interaction interface
  Volume: 73
  04/15/2013 Authors: Ivanov AA; Nim S; Du Y; Fu H
• p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.
  Volume: 73
  04/15/2013 Authors: Jin L; Li D; Lee J; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J; Boggon TJ
• Window of opportunity preoperative interrogation of mTOR pathway in patients with resectable non-small cell lung cancer (NSCLC).
  Volume: 73
  04/15/2013 Authors: Owonikoko TK; Miller DL; Force S; Sica G; Kono S; Behera M; Mendel J; Chen Z; Pickens A; Fu RW
• Screening of novel small molecule inhibitors of NF-(kappa) B activation in lung cancer
  Volume: 27
  04/01/2013 Authors: Umstead M; Du Y; Yoo MH; Khuri F; Fu H
• Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation.
  Oncogene Volume: 32 Page(s): 1030 - 1040
  02/21/2013 Authors: Qi Q; He K; Liu X; Pham C; Meyerkord C; Fu H; Ye K
• Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway.
  Oncol Rep Volume: 29 Page(s): 430 - 436
  02/01/2013 Authors: Chen M; Du Y; Qui M; Wang M; Chen K; Huang Z; Jiang M; Xiong F; Chen J; Zhou J
• Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.
  Bioorg Med Chem Lett Volume: 22 Page(s): 6085 - 6088
  10/01/2012 Authors: Li W; Li N; Tang Y; Li B; Liu L; Zhang X; Fu H; Duan J-A
• Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.
  Chem Biol Volume: 19 Page(s): 752 - 763
  06/22/2012 Authors: Smith SME; Min J; Ganesh T; Diebold B; Kawahara T; Zhu Y; McCoy J; Sun A; Snyder JP; Fu H
• Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis.
  Bioorg Med Chem Lett Volume: 22 Page(s): 4179 - 4181
  06/15/2012 Authors: Yan Y-M; Dai H-Q; Du Y; Schneider B; Guo H; Li D-P; Zhang L-X; Fu H; Dong X-P; Cheng Y-X
• Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts.
  Integr Biol (Camb) Volume: 4 Page(s): 633 - 640
  06/01/2012 Authors: Zhu S; Moore TW; Lin X; Morii N; Mancini A; Howard RB; Culver D; Arrendale RF; Reddy P; Evers TJ
• The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.
  Leuk Res Volume: 36 Page(s): 784 - 790
  06/01/2012 Authors: Ramachandiran S; Cain J; Liao A; He Y; Guo X; Boise LH; Fu H; Ratner L; Khoury HJ; Bernal-Mizrachi L
• A phase I and pharmacokinetic study of multiple schedules of ganetespib (STA-9090), a heat shock protein 90 inhibitor, in combination with docetaxel for subjects with advanced solid tumor malignancies
  Volume: 30
  05/20/2012 Authors: Kauh JS; Harvey RD; Owonikoko TK; El-Rayes BF; Shin DM; Murali S; Lewis CM; Karol MD; Teofilovici F; Du Y
• 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.
  FEBS Lett Volume: 586 Page(s): 1111 - 1119
  04/24/2012 Authors: Bai Y; Zhou T; Fu H; Sun H; Huang B
• An endogenous mTOR inhibitor, PRAS40, is upregulated in lung cancer and contributes to tumor cell invasion and chemoresistance
  CANCER RESEARCH Volume: 72
  04/15/2012 Authors: Li Z; Du Y; Sica G; Ramalingam SS; Gal AA; Pan L; Tighiouart MM; Khuri FRFR; Fu H
• Nuclear PRAS40 regulates the cellular response to nucleolar stress
  CANCER RESEARCH Volume: 72
  04/15/2012 Authors: Havel JJ; Li Z; Fu H
• 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.
  DNA Repair (Amst) Volume: 11 Page(s): 267 - 277
  03/01/2012 Authors: Andersen SD; Keijzers G; Rampakakis E; Engels K; Luhn P; El-Shemerly M; Nielsen FC; Du Y; May A; Bohr VA
• Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.
  J Biol Chem Volume: 287 Page(s): 6113 - 6127
  02/24/2012 Authors: Qi Q; He K; Yoo M-H; Chan C-B; Liu X; Zhang Z; Olson JJ; Xiao G; Wang L; Mao H
• Label-Free Resonant Waveguide Grating (RWG) Biosensor Technology for Noninvasive Detection of Oncogenic Signaling Pathways in Cancer Cells
  Page(s): 171 - 184
  01/01/2012 Authors: Du Y; Qui M; Fu H
• CHEMICAL GENOMICS Preface
  Page(s): XI - XI
  01/01/2012 Authors: Fu H
• Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
  Mol Cell Volume: 44 Page(s): 864 - 877
  12/23/2011 Authors: Hitosugi T; Fan J; Chung T-W; Lythgoe K; Wang X; Xie J; Ge Q; Gu T-L; Polakiewicz RD; Roesel JL
• Ebselen Congeners Inhibit NADPH-oxidase 2 (Nox2)-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits
  Volume: 51 Page(s): S98 - S98
  11/01/2011 Authors: Smith SME; Min J; Ganesh T; Kawahara T; Diebold B; Zhu Y; McCoy J; Sun A; Snyder JP; Fu H
• Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 16212 - 16216
  09/27/2011 Authors: Zhao J; Du Y; Horton JR; Upadhyay AK; Lou B; Bai Y; Zhang X; Du L; Li M; Wang B
• 14-3-3 proteins as potential therapeutic targets.
  Semin Cell Dev Biol Volume: 22 Page(s): 705 - 712
  09/01/2011 Authors: Zhao J; Meyerkord CL; Du Y; Khuri FR; Fu H
• A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.
  J Biomol Screen Volume: 16 Page(s): 836 - 844
  09/01/2011 Authors: Li L; Du Y; Chen W; Fu H; Harrison DG
• NMR spectroscopy of 14-3-3 reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3.
  Biochem J Volume: 437 Page(s): 493 - 503
  08/01/2011 Authors: Williams DM; Ecroyd H; Goodwin KL; Dai H; Fu H; Woodcock JM; Zhang L; Carver JA
• A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.
  Assay Drug Dev Technol Volume: 9 Page(s): 382 - 393
  08/01/2011 Authors: Du Y; Nikolovska-Coleska Z; Qui M; Li L; Lewis I; Dingledine R; Stuckey JA; Krajewski K; Roller PP; Wang S
• Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.
  J Virol Volume: 85 Page(s): 6381 - 6389
  07/01/2011 Authors: Cencic R; Desforges M; Hall DR; Kozakov D; Du Y; Min J; Dingledine R; Fu H; Vajda S; Talbot PJ
• MOLECULAR MECHANISMS OF CHEMOPREVENTIVE COMPOUNDS AND NOVEL APPROACHES (MOLECULAR IMAGING) TO ASSESS EFFICACY
  JOURNAL OF THORACIC ONCOLOGY Volume: 6 Page(s): S115 - S116
  06/01/2011 Authors: Khuri FR; Sun S-Y; Brandes JC; Fu H
• LKB1 negatively regulates IGF-1 induced ERK phosphorylation
  CANCER RESEARCH Volume: 71
  04/15/2011 Authors: Zhong D; Liu X; Fu H; Sun S-Y; Khuri FR; Zhou W
• The Cables1 protein complex couples survival signaling to cell death machinery
  CANCER RESEARCH Volume: 71
  04/15/2011 Authors: Shi Z; Park HR; Du Y; Fu H; Khuri FR
• Discovering small-molecule estrogen receptor /coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.
  ChemMedChem Volume: 6 Page(s): 654 - 666
  04/04/2011 Authors: Sun A; Moore TW; Gunther JR; Kim M-S; Rhoden E; Du Y; Fu H; Snyder JP; Katzenellenbogen JA
• Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 1046 - 1051
  01/18/2011 Authors: Cencic R; Hall DR; Robert F; Du Y; Min J; Li L; Qui M; Lewis I; Kurtkaya S; Dingledine R
• Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-B signaling pathway.
  J Med Chem Volume: 53 Page(s): 8260 - 8273
  12/09/2010 Authors: Qiu X; Du Y; Lou B; Zuo Y; Shao W; Huo Y; Huang J; Yu Y; Zhou B; Du J
• Novel Mcl-1 inhibitors for pancreatic cancer therapy
  Volume: 8 Page(s): 94 - 94
  11/01/2010 Authors: Nikolovska-Coleska Z; Bajwa N; Liu M; Azmi A; Stuckey J; Tomita Y; Mohammad R; Fu H
• Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.
  Biochem Pharmacol Volume: 80 Page(s): 1309 - 1316
  11/01/2010 Authors: Thomas SL; Zhao J; Li Z; Lou B; Du Y; Purcell J; Snyder JP; Khuri FR; Liotta D; Fu H
• 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
  Nat Struct Mol Biol Volume: 17 Page(s): 1124 - 1135
  09/01/2010 Authors: Xu Z; Fulop Z; Wu G; Pone EJ; Zhang J; Mai T; Thomas LM; Al-Qahtani A; White CA; Park S-R
• Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer.
  Cancer Volume: 116 Page(s): 3903 - 3909
  08/15/2010 Authors: Ramalingam SS; Harvey RD; Saba N; Owonikoko TK; Kauh J; Shin DM; Sun S-Y; Strychor S; Tighiouart M; Egorin MJ
• MicroRNA-21 is involved in ionizing radiation-promoted liver carcinogenesis.
  Int J Clin Exp Med Volume: 3 Page(s): 211 - 222
  07/31/2010 Authors: Zhu Y; Yu X; Fu H; Wang H; Wang P; Zheng X; Wang Y
• THE BIOLOGICAL SIGNIFICANCE OF TARGETED THERAPIES: THE DEVELOPMENT OF MTOR INHIBITORS
  JOURNAL OF THORACIC ONCOLOGY Volume: 5 Page(s): S27 - S27
  05/01/2010 Authors: Khuri FR; Ramalingam SS; Owonikoko TK; Sun S-Y; Fu H
• Monitoring GTPCH-1 Interaction with GFRP Using Time-Resolved Fluorescence Resonance Energy Transfer
  FASEB JOURNAL Volume: 24
  04/01/2010 Authors: Li L; Du Y; Fu H; Salerno JC; Chen W; Harrison DG
• Inhibition of ASK1 through phosphorylation of serine 967 by PI3K/Akt-mediated pathways
  Volume: 70
  04/01/2010 Authors: Puckett MC; Goldman E; Cockrell L; Khuri F; Fu H
• Small molecule inhibitors of estrogen receptor a/coactivator binding: Synthesis and in vitro and cell-based biological evaluation
  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 239
  03/21/2010 Authors: Sun A; Moore T; Gunther JR; Kim M-S; Rhoden E; Du Y; Fu H; Snyder JP; Katzenellenbogen JA
• Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5 alpha, 6 beta-triol, with new activities from the marine-derived fungus Trichoderma sp.
  J Ind Microbiol Biotechnol Volume: 37 Page(s): 245 - 252
  03/01/2010 Authors: You J; Dai H; Chen Z; Liu G; He Z; Song F; Yang X; Fu H; Zhang L; Chen X
• Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.
  Oncogene Volume: 29 Page(s): 822 - 830
  02/11/2010 Authors: Cockrell LM; Puckett MC; Goldman EH; Khuri FR; Fu H
• RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.
  Gastroenterology Volume: 138 Page(s): 231-40.e1-5
  01/01/2010 Authors: Yang G; Fu H; Zhang J; Lu X; Yu F; Jin L; Bai L; Huang B; Shen L; Feng Y
• 14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer.
  Clin Cancer Res Volume: 15 Page(s): 7571 - 7581
  12/15/2009 Authors: Titus MA; Tan J-A; Gregory CW; Ford OH; Subramanian RR; Fu H; Wilson EM; Mohler JL; French FS
• Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins.
  Biochem Biophys Res Commun Volume: 389 Page(s): 455 - 460
  11/20/2009 Authors: Wang R; He H; Sun X; Xu J; Marshall FF; Zhau H; Chung LWK; Fu H; He D
• Genomic Stability: A Novel Function of NF-Kb in Lymphomas
  Volume: 114 Page(s): 1255 - 1256
  11/20/2009 Authors: Ramachandiran S; Adone A; Guo X; Liao A; Sunay UR; Ratner L; Fu H; Lossos IS; Saavedra H; Bernal-Mizrachi L
• A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
  J Neurosci Volume: 29 Page(s): 11399 - 11408
  09/09/2009 Authors: Fu H; Cai J; Clevers H; Fast E; Gray S; Greenberg R; Jain MK; Ma Q; Qiu M; Rowitch DH
• Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
  J Biol Chem Volume: 284 Page(s): 24512 - 24525
  09/04/2009 Authors: Jang S-W; Liu X; Fu H; Rees H; Yepes M; Levey A; Ye K
• Induction trial of RAD001 in operable lung cancer
  JOURNAL OF THORACIC ONCOLOGY Volume: 4 Page(s): S43 - S44
  09/01/2009 Authors: Khuri FR; Ramalingam S; Fu H; Sun S-Y
• High throughput screening and the discovery of natural product-derived compounds for cancer prevention
  JOURNAL OF THORACIC ONCOLOGY Volume: 4 Page(s): S214 - S215
  09/01/2009 Authors: Fu H
• Molecular modeling of coactivator binding inhibitors (CBIs) of estrogen receptor alpha
  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 238
  08/16/2009 Authors: Kim M-S; Sun A; Gunther J; Moore T; Rhoden E; Du Y; Fu H; Snyder JP; Katzenellenbogen JA
• 14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen.
  J Biol Chem Volume: 284 Page(s): 22379 - 22389
  08/14/2009 Authors: Maxwell SA; Li Z; Jaya D; Ballard S; Ferrell J; Fu H
• Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
  Mol Cell Volume: 34 Page(s): 497 - 509
  05/14/2009 Authors: Aslan JE; You H; Williamson DM; Endig J; Youker RT; Thomas L; Shu H; Du Y; Milewski RL; Brush MH
• Anticancer activity profiling of a panel of curcumin analogues in head and neck and lung cancer cells
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Lou B; Du Y; Kasinski A; Thomas S; Sun A; Sun S-Y; Chen G; Shin D; Khuri F; Liotta D
• Developing protein interaction biosensor technologies for monitoring 14-3-3 signaling complexes in cancer
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Havel J; Fu H
• Label-free biosensor technology for monitoring oncogenic signaling pathways
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Du Y; Zhao J; Chen ZG; Shin DM; Khui FR; Fu H
• Regulation of the tumor suppressor Cables1 by Akt/PKB-induced 14-3-3 interaction
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Shi Z; Park HR; Li Z; Ho C; Khuri F; Fu H
• Regulation of the tumor suppressor Cablesl by Akt/PKB-induced 14-3-3 interaction
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Shi Z; Park HR; Li Z; Ho C; Khuri F; Fu H
• Anticancer activity profiling of a panel of curcumin analogues in head and neck and lung cancer cells
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Iou B; Du Y; Kasinski A; Thomas S; Sun A; Sun S-Y; Chen G; Shin D; Khuri F; Liotta D
• Identification of the 14-3-3/HIP-55 protein complex as a negative regulator of HPK1 in the Akt signaling
  FASEB JOURNAL Volume: 23
  04/01/2009 Authors: Li Z; Shi Z; Park HR; Li Z; Fu H
• Identification of a Novel Regulatory Element Controlling ASK1-JNK Signaling
  FASEB JOURNAL Volume: 23
  04/01/2009 Authors: Puckett MC; Cockrell LM; DeSimone M; Vellano C; Fu H
• Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.
  Mol Cancer Ther Volume: 8 Page(s): 563 - 570
  03/01/2009 Authors: Bialkowska AB; Du Y; Fu H; Yang VW
• A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding.
  J Biomol Screen Volume: 14 Page(s): 181 - 193
  02/01/2009 Authors: Gunther JR; Du Y; Rhoden E; Lewis I; Revennaugh B; Moore TW; Kim SH; Dingledine R; Fu H; Katzenellenbogen JA
• How does arrestin assemble MAPKs into a signaling complex?
  J Biol Chem Volume: 284 Page(s): 685 - 695
  01/02/2009 Authors: Song X; Coffa S; Fu H; Gurevich VV
• Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells.
  J Recept Signal Transduct Res Volume: 29 Page(s): 182 - 194
  01/01/2009 Authors: Du Y; Li Z; Li L; Chen ZG; Sun S-Y; Chen P; Shin DM; Khuri FR; Fu H
• Novel Regulation of Nox 2 by 14-3-3 Signaling Proteins
  Volume: 47 Page(s): S43 - S43
  01/01/2009 Authors: Diebold BA; Fu H; Lambeth JD
• Cancer and virus leads by HTS, chemical design and SEA data mining.
  Curr Top Med Chem Volume: 9 Page(s): 1159 - 1171
  01/01/2009 Authors: Thepchatri P; Min J; Ganesh T; Du Y; Lewis I; Kurtkaya S; Prussia A; Li L; Sneed B; Plemper RK
• Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy.
  Cancer Biol Ther Volume: 7 Page(s): 1952 - 1958
  12/01/2008 Authors: Wang X; Hawk N; Yue P; Kauh J; Ramalingam SS; Fu H; Khuri FR; Sun S-Y
• A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides.
  Curr Chem Genomics Volume: 2 Page(s): 40 - 47
  11/06/2008 Authors: Du Y; Khuri FR; Fu H
• Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.
  Cancer Res Volume: 68 Page(s): 7409 - 7418
  09/15/2008 Authors: Wang X; Yue P; Kim YA; Fu H; Khuri FR; Sun S-Y
• Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.
  Bioorg Med Chem Lett Volume: 18 Page(s): 4982 - 4987
  09/15/2008 Authors: Ganesh T; Thepchatri P; Li L; Du Y; Fu H; Snyder JP; Sun A
• Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
  Mol Pharmacol Volume: 74 Page(s): 654 - 661
  09/01/2008 Authors: Kasinski AL; Du Y; Thomas SL; Zhao J; Sun S-Y; Khuri FR; Wang C-Y; Shoji M; Sun A; Snyder JP
• Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
  Bioorg Med Chem Volume: 16 Page(s): 6903 - 6910
  07/15/2008 Authors: Ganesh T; Min J; Thepchatri P; Du Y; Li L; Lewis I; Wilson L; Fu H; Chiosis G; Dingledine R
• AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.
  Circ Res Volume: 102 Page(s): 840 - 848
  04/11/2008 Authors: Min W; Lin Y; Tang S; Yu L; Zhang H; Wan T; Luhn T; Fu H; Chen H
• The recurring AGCT motif in S region DNA specifically recruits 14-3-3 adaptor proteins that are critical for the unfolding of CSR
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Xu Z; Fulop Z; Zhang J; Al-Qahtani A; Pone E; Pal Z; Park S-R; Zan H; Fu H; Yates J
• Synergistic Anticancer Potential of the Combination of the Novel Curcumin Analog EF24 and p38 MAPK Inhibitors
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Thomas S; Khuri F; Snyder J; Liotta D; Fu H
• Role of 14-3-3zeta in Anoikis Resistance and Anchorage-independent Growth of Lung Cancer Cells
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Zhao J; Li Z; Du Y; Park HR; Sun S-Y; Khuri F; Fu H
• Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.
  Proc Natl Acad Sci U S A Volume: 105 Page(s): 162 - 167
  01/08/2008 Authors: Li Z; Zhao J; Du Y; Park HR; Sun S-Y; Bernal-Mizrachi L; Aitken A; Khuri FR; Fu H
• Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
  Mol Cell Biol Volume: 27 Page(s): 7405 - 7413
  11/01/2007 Authors: Wang X; Yue P; Chan C-B; Ye K; Ueda T; Watanabe-Fukunaga R; Fukunaga R; Fu H; Khuri FR; Sun S-Y
• High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.
  J Biomol Screen Volume: 12 Page(s): 915 - 924
  10/01/2007 Authors: Du Y; Moulick K; Rodina A; Aguirre J; Felts S; Dingledine R; Fu H; Chiosis G
• 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
  Blood Volume: 110 Page(s): 360 - 369
  07/01/2007 Authors: Dong S; Kang S; Gu T-L; Kardar S; Fu H; Lonial S; Khoury HJ; Khuri F; Chen J
• Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.
  Antimicrob Agents Chemother Volume: 51 Page(s): 2293 - 2303
  07/01/2007 Authors: White LK; Yoon J-J; Lee JK; Sun A; Du Y; Fu H; Snyder JP; Plemper RK
• Identification of FAKTS as a novel 14-3-3-associated nuclear protein.
  Proteins Volume: 67 Page(s): 479 - 489
  05/01/2007 Authors: Luhn P; Wang H; Marcus AI; Fu H
• cAMP/adenylyl cyclase stimulation promotes 14-3-3 binding to UT-A1 urea transporter
  Volume: 21 Page(s): A906 - A906
  04/01/2007 Authors: Chen G; Li Z; Klein JD; Yang Y; Frhlich O; Du Y; Fu H; Sands JM
• 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
  J Biol Chem Volume: 282 Page(s): 4748 - 4756
  02/16/2007 Authors: Rong J; Li S; Sheng G; Wu M; Coblitz B; Li M; Fu H; Li X-J
• Glial cell line-derived neurotrophic factor-mediated enteric neuronal survival involves glycogen synthase kinase-3beta phosphorylation and coupling with 14-3-3.
  Neuroscience Volume: 143 Page(s): 241 - 251
  11/17/2006 Authors: Mwangi S; Anitha M; Fu H; Sitaraman SV; Srinivasan S
• 14-3-3 integrates pro-survival signals in hematopoietic cells transformed by diverse leukemogenic tyrosine kinases, and represents a common target.
  Volume: 108 Page(s): 337A - 337A
  11/16/2006 Authors: Dong S; Kang S; Gu T-L; Kardar S; Lonial S; Khoury HJ; Khuri F; Fu H; Chen J
• Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells.
  J Neurosci Volume: 26 Page(s): 9153 - 9161
  09/06/2006 Authors: Pozdeyev N; Taylor C; Haque R; Chaurasia SS; Visser A; Thazyeen A; Du Y; Fu H; Weller J; Klein DC
• Targeting protein-protein interactions in signaling pathways for therapeutic interventions
  ACTA PHARMACOLOGICA SINICA Volume: 27 Page(s): 26 - 26
  07/01/2006 Authors: Du Y; Luhn P; Park H; Sun S; Khuri FR; Fu H
• Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.
  Semin Cancer Biol Volume: 16 Page(s): 193 - 202
  06/01/2006 Authors: Porter GW; Khuri FR; Fu H
• Monitoring 14-3-3 protein interactions with a homogeneous fluorescence polarization assay.
  J Biomol Screen Volume: 11 Page(s): 269 - 276
  04/01/2006 Authors: Du Y; Masters SC; Khuri FR; Fu H
• 14-3-3 : PRAS40 interaction mediates an Akt proliferative signal
  Volume: 20 Page(s): A691 - A691
  03/06/2006 Authors: Porter G; Fu HA
• SWTY--a general peptide probe for homogeneous solution binding assay of 14-3-3 proteins.
  Anal Biochem Volume: 349 Page(s): 186 - 196
  02/15/2006 Authors: Wu M; Coblitz B; Shikano S; Long S; Cockrell LM; Fu H; Li M
• Targeting mTOR signaling for lung cancer therapy.
  J Thorac Oncol Volume: 1 Page(s): 109 - 111
  02/01/2006 Authors: Sun S-Y; Fu H; Khuri FR
• C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors.
  J Biol Chem Volume: 280 Page(s): 36263 - 36272
  10/28/2005 Authors: Coblitz B; Shikano S; Wu M; Gabelli SB; Cockrell LM; Spieker M; Hanyu Y; Fu H; Amzel LM; Li M
• Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.
  EMBO J Volume: 24 Page(s): 3543 - 3554
  10/19/2005 Authors: Hu Y; Yao J; Liu Z; Liu X; Fu H; Ye K
• Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.
  Cancer Res Volume: 65 Page(s): 7052 - 7058
  08/15/2005 Authors: Sun S-Y; Rosenberg LM; Wang X; Zhou Z; Yue P; Fu H; Khuri FR
• The farnesyltransferase inhibitor Lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of Akt.
  Cancer Biol Ther Volume: 3 Page(s): 1092 - 1098
  11/01/2004 Authors: Sun S-Y; Zhou Z; Wang R; Fu H; Khuri FR
• Raf-1 activation disrupts its binding to keratins during cell stress.
  J Cell Biol Volume: 166 Page(s): 479 - 485
  08/16/2004 Authors: Ku N-O; Fu H; Omary MB
• Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation.
  Blood Volume: 104 Page(s): 535 - 542
  07/15/2004 Authors: Chen J; Williams IR; Kutok JL; Duclos N; Anastasiadou E; Masters SC; Fu H; Gilliland DG
• Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.
  Oncogene Volume: 23 Page(s): 5099 - 5104
  06/24/2004 Authors: Fujii K; Goldman EH; Park HR; Zhang L; Chen J; Fu H
• Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.
  Exp Cell Res Volume: 294 Page(s): 581 - 591
  04/01/2004 Authors: Subramanian RR; Zhang H; Wang H; Ichijo H; Miyashita T; Fu H
• Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation.
  J Biol Chem Volume: 279 Page(s): 10442 - 10449
  03/12/2004 Authors: Goldman EH; Chen L; Fu H
• Targeting 14-3-3/ligand interactions in NSCLC.
  Volume: 9 Page(s): 6242S - 6242S
  12/01/2003 Authors: Park HR; Luhn PA; Zhang HY; Montoya LM; Sun SY; Khuri FR; Fu H
• Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta.
  J Biol Chem Volume: 278 Page(s): 41557 - 41565
  10/17/2003 Authors: Hamaguchi A; Suzuki E; Murayama K; Fujimura T; Hikita T; Iwabuchi K; Handa K; Withers DA; Masters SC; Fu H
• A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCdelta: a preliminary note.
  Biochem Biophys Res Commun Volume: 307 Page(s): 589 - 594
  08/01/2003 Authors: Hamaguchi A; Suzuki E; Murayama K; Fujimura T; Hikita T; Iwabuchi K; Handa K; Withers DA; Masters SC; Fu H
• Interaction of 14-3-3 with MAP3K6, a protein kinase with homology to ASK1
  Volume: 17 Page(s): A1031 - A1031
  03/17/2003 Authors: Montoya LM; Goldman EH; Fu H
• A novel mechanism for reactive oxygen, species-induced activation of ASK1
  Volume: 17 Page(s): A1032 - A1033
  03/17/2003 Authors: Goldman EH; Chen L; Fu H
• Role of the 14-3-3 C-terminal loop in ligand interaction.
  Proteins Volume: 49 Page(s): 321 - 325
  11/15/2002 Authors: Truong AB; Masters SC; Yang H; Fu H
• Survival-promoting functions of 14-3-3 proteins.
  Biochem Soc Trans Volume: 30 Page(s): 360 - 365
  08/01/2002 Authors: Masters SC; Subramanian RR; Truong A; Yang H; Fujii K; Zhang H; Fu H
• Cellular hijacking: a common strategy for microbial infection.
  Trends Biochem Sci Volume: 27 Page(s): 308 - 314
  06/01/2002 Authors: Kahn RA; Fu H; Roy CR
• Molecular basis for the interaction between Raf-1 and Apoptosis Signal-regulating Kinase 1 (ASK1)
  FASEB JOURNAL Volume: 16 Page(s): A581 - A581
  03/20/2002 Authors: Goldman EH; Chen J; Fu H
• 14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
  Mol Pharmacol Volume: 60 Page(s): 1325 - 1331
  12/01/2001 Authors: Masters SC; Yang H; Datta SR; Greenberg ME; Fu H
• 14-3-3 proteins mediate an essential anti-apoptotic signal.
  J Biol Chem Volume: 276 Page(s): 45193 - 45200
  11/30/2001 Authors: Masters SC; Fu H
• Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
  Exp Cell Res Volume: 271 Page(s): 142 - 151
  11/15/2001 Authors: Subramanian RR; Masters SC; Zhang H; Fu H
• Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
  Proc Natl Acad Sci U S A Volume: 98 Page(s): 7783 - 7788
  07/03/2001 Authors: Chen J; Fujii K; Zhang L; Roberts T; Fu H
• The proapoptotic protein Bad binds the amphipathic groove of 14-3-3zeta.
  Biochim Biophys Acta Volume: 1547 Page(s): 313 - 319
  06/11/2001 Authors: Yang H; Masters SC; Wang H; Fu H
• Regulation of intracellular localization of ASK1 by 14-3-3 isoforms
  FASEB JOURNAL Volume: 15 Page(s): A235 - A235
  03/07/2001 Authors: Subramanian RR; Zhang HY; Ichijo H; Fu H
• Isolation and characterization of 14-3-3 mutants that bind hypophosphorylated S136A Bad: Structural implications for 14-3-3 binding
  FASEB JOURNAL Volume: 15 Page(s): A510 - A510
  03/07/2001 Authors: Truong A; Masters SC; Fu HA
• Regulation of apoptotic signal-regulating kinase(ASK)1-induced cell death by Raf-1
  MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 349A - 349A
  12/01/2000 Authors: Chen J; Fu H
• Phosphorylation of Bad on serine 136 is sufficient to induce 14-3-3 binding.
  FASEB JOURNAL Volume: 14 Page(s): A1585 - A1585
  05/11/2000 Authors: Masters SC; Datta SR; Greenberg ME; Fu H
• Modulation of 14-3-3 protein interactions with target polypeptides by physical and metabolic effectors.
  Plant Cell Physiol Volume: 41 Page(s): 523 - 533
  04/01/2000 Authors: Athwal GS; Lombardo CR; Huber JL; Masters SC; Fu H; Huber SC
• 14-3-3 proteins: structure, function, and regulation.
  Annu Rev Pharmacol Toxicol Volume: 40 Page(s): 617 - 647
  01/01/2000 Authors: Fu H; Subramanian RR; Masters SC
• Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.
  Biochemistry Volume: 38 Page(s): 12499 - 12504
  09/21/1999 Authors: Wang B; Yang H; Liu YC; Jelinek T; Zhang L; Ruoslahti E; Fu H
• Residues of 14-3-3 zeta required for activation of exoenzyme S of Pseudomonas aeruginosa.
  Biochemistry Volume: 38 Page(s): 12159 - 12164
  09/30/1999 Authors: Zhang L; Wang H; Masters SC; Wang B; Barbieri JT; Fu H
• Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.
  Proc Natl Acad Sci U S A Volume: 96 Page(s): 8511 - 8515
  07/20/1999 Authors: Zhang L; Chen J; Fu H
• Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosa.
  Biochemistry Volume: 38 Page(s): 5216 - 5221
  04/20/1999 Authors: Masters SC; Pederson KJ; Zhang L; Barbieri JT; Fu H
• 14-3-3 isoforms exhibit common and unique protein associations
  FASEB JOURNAL Volume: 13 Page(s): A467 - A467
  03/12/1999 Authors: Subramanian PR; Masters SC; Zhang L; Fu H
• Structural elements of 14-3-3zeta required for binding to bad
  FASEB JOURNAL Volume: 13 Page(s): A479 - A479
  03/12/1999 Authors: Yang H; Masters SC; Wang H; Fu H
• Regulation of apoptosis signal-regulating kinase (ASK) 1 by phosphorylation
  FASEB JOURNAL Volume: 13 Page(s): A467 - A467
  03/12/1999 Authors: Chen J; Zhang L; Fu H
• Regulation of the AKT/BAD survival pathway by 14-3-3
  FASEB JOURNAL Volume: 13 Page(s): A479 - A479
  03/12/1999 Authors: Masters SC; Datta SR; Greenberg ME; Fu H
• Control of apoptosis signal-regulating kinase 1 by 14-3-3 proteins
  MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 232A - 232A
  11/01/1998 Authors: Zhang LX; Fu HA
• Phosphorylation of 14-3-3 by an ASK1 sensitive protein kinase.
  MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 231A - 231A
  11/01/1998 Authors: Chen J; Zhang L; Fu H
• Modulation of BAD induced cell death by 14-3-3 and Akt.
  MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 108A - 108A
  11/01/1998 Authors: Masters SC; Datta SR; Greenberg ME; Fu H
• A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.
  J Biol Chem Volume: 273 Page(s): 21834 - 21845
  08/21/1998 Authors: Megidish T; Cooper J; Zhang L; Fu H; Hakomori S
• Mutations in the hydrophobic surface of an amphipathic groove of 14-3-3zeta disrupt its interaction with Raf-1 kinase.
  J Biol Chem Volume: 273 Page(s): 16297 - 16304
  06/26/1998 Authors: Wang H; Zhang L; Liddington R; Fu H
• 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
  J Biol Chem Volume: 273 Page(s): 16305 - 16310
  06/26/1998 Authors: Petosa C; Masters SC; Bankston LA; Pohl J; Wang B; Fu H; Liddington RC
• Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1.
  J Biol Chem Volume: 273 Page(s): 1970 - 1981
  01/23/1998 Authors: Fu H; Sadis S; Rubin DM; Glickman M; van Nocker S; Finley D; Vierstra RD
• Structural elements of 14-3-3 zeta required for its interaction with Raf-1 kinase.
  MOLECULAR BIOLOGY OF THE CELL Volume: 8 Page(s): 1414 - 1414
  11/01/1997 Authors: Wang HN; Zhang LX; Liddington R; Fu HA
• Characterization of the 14-3-3/Bad interaction.
  MOLECULAR BIOLOGY OF THE CELL Volume: 8 Page(s): 1452 - 1452
  11/01/1997 Authors: Masters SC; Datta SR; Greenberg ME; Fu H
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Cell Volume: 91 Page(s): 231 - 241
  10/17/1997 Authors: Datta SR; Dudek H; Tao X; Masters S; Fu H; Gotoh Y; Greenberg ME
• 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain.
  J Biol Chem Volume: 272 Page(s): 20990 - 20993
  08/22/1997 Authors: Clark GJ; Drugan JK; Rossman KL; Carpenter JW; Rogers-Graham K; Fu H; Der CJ; Campbell SL
• Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
  J Biol Chem Volume: 272 Page(s): 13717 - 13724
  05/23/1997 Authors: Zhang L; Wang H; Liu D; Liddington R; Fu H
• Selection of diphtheria toxin active-site mutants in yeast. Rediscovery of glutamic acid-148 as a key residue.
  Volume: 419 Page(s): 45 - 52
  01/01/1997 Authors: Fu H; Blanke SR; Mattheakis LC; Collier RJ
• Mutational analysis of the 14-3-3/ligand interactions.
  MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 55 - 55
  12/01/1996 Authors: Wang HN; Zhang LX; Fu H
• Crystal structure of the zeta isoform of the 14-3-3 protein.
  Nature Volume: 376 Page(s): 191 - 194
  07/13/1995 Authors: Liu D; Bienkowska J; Petosa C; Collier RJ; Fu H; Liddington R
• Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
  Science Volume: 266 Page(s): 126 - 129
  10/07/1994 Authors: Fu H; Xia K; Pallas DC; Cui C; Conroy K; Narsimhan RP; Mamon H; Collier RJ; Roberts TM
• Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
  Science Volume: 266 Page(s): 129 - 133
  10/07/1994 Authors: Reuther GW; Fu H; Cripe LD; Collier RJ; Pendergast AM
• Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
  Science Volume: 265 Page(s): 535 - 537
  07/22/1994 Authors: Pallas DC; Fu H; Haehnel LC; Weller W; Collier RJ; Roberts TM
• ACTIVATION OF ADP-RIBOSYLATING EXOENZYME-S OF PSEUDOMONAS-AERUGINOSA BY A EUKARYOTIC 14-3-3 PROTEIN
  Volume: 24 Page(s): 388 - 389
  01/01/1994 Authors: FU H; COBURN J; COLLIER RJ
• The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family.
  Proc Natl Acad Sci U S A Volume: 90 Page(s): 2320 - 2324
  03/15/1993 Authors: Fu H; Coburn J; Collier RJ
• THE RECEPTOR-BINDING DOMAIN OF DIPHTHERIA-TOXIN AS A POTENTIAL IMMUNOGEN AGAINST DIPHTHERIA
  JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 67 - 67
  02/08/1993 Authors: COLLIER RJ; SHEN WH; FU H