Elizabeth Leslie-Clarkson
- Department of Human Genetics
Associate Professor
- (404) 727-3505
- ejlesli@emory.edu
- Emory Cleft Project Website
- Lab Website
-
615 Michael Street
Suite 305N
Atlanta, GA 30322
Overview
Dr. Leslie's research combines genomics with deep phenotyping to understand the genetic architecture of craniofacial birth defects and fundamental questions of phenotypic heterogeneity, penetrance, and variable expressivity. In addition to identifying new loci for nonsyndromic cleft lip and palate, she is one of the leading experts on Van der Woude syndrome, the most common Mendelian clefting syndrome. She received her PhD in Genetics from the University of Iowa and postdoctoral training at the University of Pittsburgh, where she previously held a faculty position in Oral Biology.
Academic Appointment
- Assistant Professor, Human Genetics, Emory University
Education
Degrees
- PhD from University of Iowa
- BA from St. Olaf College
Research
Publications
-
Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder.
Am J Hum Genet Volume: 112 Page(s): 1388 - 1414
06/05/2025 Authors: Prez Baca MDR; Palomares-Bralo M; Vanhooydonck M; Hamerlinck L; D'haene E; Leimbacher S; Jacobs EZ; De Cock L; D'haenens E; Dheedene A -
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy.
01/17/2025 Authors: Robinson K; Singh SK; Walkup RB; Fawwal DV; Adeyemo WL; Beaty TH; Butali A; Bux CJ; Chung WK; Cutler DJ -
Building a growing genomic repository for maternal and fetal health through the PING Consortium.
Pediatr Res
01/03/2025 Authors: Abdelmalek CM; Singh S; Fasil B; Horvath AR; Mulkey SB; Cur C; Campos M; Cavalcanti DP; Tong VT; Mercado M -
Gene-by-environment interactions involving maternal exposures with orofacial cleft risk in Filipinos.
medRxiv
12/17/2024 Authors: Erdogan-Yildirim Z; Carlson JC; Mukhopadhyay N; Leslie EJ; Padilla C; Murray JC; Beaty TH; Weinberg SM; Marazita ML; Shaffer JR -
Genome-wide study of gene-by-sex interactions identifies risks for cleft palate.
Hum Genet Volume: 143 Page(s): 1341 - 1352
11/01/2024 Authors: Robinson K; Parrish R; Adeyemo WL; Beaty TH; Butali A; Bux CJ; Gowans LJJ; Hecht JT; Moreno Uribe L; Murray JC -
Genome-wide association studies of Down syndrome associated congenital heart defects.
09/06/2024 Authors: Feldman ER; Li Y; Cutler DJ; Rosser TC; Wechsler SB; Sanclemente L; Rachubinski AL; Elliott N; Vyas P; Roberts I -
Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis.
Commun Biol Volume: 7 Page(s): 1040
08/23/2024 Authors: Caetano da Silva C; Macias Trevino C; Mitchell J; Murali H; Tsimbal C; Dalessandro E; Carroll SH; Kochhar S; Curtis SW; Cheng CHE -
Investigating gene functions and single-cell expression profiles of de novo variants in orofacial clefts.
HGG Adv Volume: 5 Page(s): 100313
07/18/2024 Authors: Itai T; Yan F; Liu A; Dai Y; Iwaya C; Curtis SW; Leslie EJ; Simon LM; Jia P; Chen X -
Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis.
bioRxiv
07/02/2024 Authors: da Silva CC; Trevino CM; Mitchell J; Murali H; Tsimbal C; Dalessandro E; Carroll SH; Kochhar S; Curtis SW; Cheng CHE -
Building a growing genomic data repository for maternal and fetal health through the PING Consortium.
medRxiv
05/25/2024 Authors: Abdelmalek CM; Singh S; Fasil B; Horvath AR; Mulkey SB; Cur C; Campos M; Cavalcanti DP; Tong VT; Mercado M