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Profile

Changsheng Zhao

  • Department of Human Genetics
    Associate Professor
  • changsheng.zhao@emory.edu

  • 1760 Haygood Dr NE, Suite E369A
Head shot of Changsheng Zhao

Overview

Our research primarily utilizes bioinformatics approaches to analyze high-throughput genomic data, aiming to unravel the molecular mechanisms underlying prostate cancer. Over the years, we has garnered extensive experience in Cancer Genomics and Bioinformatics, particularly in analyzing various data types such as Microarray, ChIP-seq, RNA-seq, ATAC-seq, scRNA-seq, scATAT-seq, Hi-C, Spatial Transcriptomics, MeDIP-Seq, BS-Seq, and Nanopore Long-read sequencing.

We have developed numerous computational pipelines for the routine processing of NGS data and are proactive in integrating newly published genomic data and acquiring advanced bioinformatics skills/tools. We are extending our research to other types of urological cancers, such as kidney and bladder cancers. Additionally, Our collaborative skills are well-demonstrated through multiple co-investigator grants and a wealth of co-authored publications.

Academic Appointment

  • Associate Professor, Human Genetics, Emory University School of Medicine

Education

Degrees

  • MD from Peking University
  • MA Math, Computer Science from Eastern Michigan University

Research

Publications

  • Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma.
    Cancer Biol Ther Volume: 25 Page(s): 2364433
    12/31/2024 Authors: Naranjo NM; Kennedy A; Testa A; Verrillo CE; Altieri AD; Kean R; Hooper DC; Yu J; Zhao J; Abinader O
  • Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.
    J Clin Invest Volume: 133
    08/01/2023 Authors: Gritsina G; Fong K-W; Lu X; Lin Z; Xie W; Agarwal S; Lin D; Schiltz GE; Beltran H; Corey E
  • Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
    Oncogene Volume: 42 Page(s): 2126 - 2138
    06/01/2023 Authors: Lin Z; Agarwal S; Tan S; Shi H; Lu X; Tao Z; Dong X; Wu X; Zhao JC; Yu J
  • PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
    Mol Cell Volume: 82 Page(s): 4611 - 4626.e7
    12/15/2022 Authors: Fong K-W; Zhao JC; Lu X; Kim J; Piunti A; Shilatifard A; Yu J
  • FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A.
    Oncogene Volume: 41 Page(s): 4259 - 4270
    09/01/2022 Authors: Wang X; Brea L; Lu X; Gritsina G; Park SH; Xie W; Zhao JC; Yu J
  • HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.
    Nat Genet Volume: 54 Page(s): 670 - 683
    05/01/2022 Authors: Lu X; Fong K-W; Gritsina G; Wang F; Baca SC; Brea LT; Berchuck JE; Spisak S; Ross J; Morrissey C
  • Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
    Sci Adv Volume: 7
    04/01/2021 Authors: Park SH; Fong K-W; Kim J; Wang F; Lu X; Lee Y; Brea LT; Wadosky K; Guo C; Abdulkadir SA
  • Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.
    Nat Commun Volume: 11 Page(s): 4153
    08/19/2020 Authors: Vatapalli R; Sagar V; Rodriguez Y; Zhao JC; Unno K; Pamarthy S; Lysy B; Anker J; Han H; Yoo YA
  • Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
    Cancer Res Volume: 80 Page(s): 2072
    05/15/2020 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Sharp A; Yuan W; Aversa C; Yang XJ
  • Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.
    Cell Res Volume: 29 Page(s): 773 - 775
    09/01/2019 Authors: Xu B; Song B; Lu X; Kim J; Hu M; Zhao JC; Yu J
  • Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
    Cancer Res Volume: 79 Page(s): 2580 - 2592
    05/15/2019 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Sharp A; Yuan W; Aversa C; Yang XJ
  • Targeting FOXA1-mediated repression of TGF- signaling suppresses castration-resistant prostate cancer progression.
    J Clin Invest Volume: 129 Page(s): 569 - 582
    02/01/2019 Authors: Song B; Park S-H; Zhao JC; Fong K-W; Li S; Lee Y; Yang YA; Sridhar S; Lu X; Abdulkadir SA
  • Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.
    Cell Rep Volume: 25 Page(s): 2808 - 2820.e4
    12/04/2018 Authors: Kim J; Lee Y; Lu X; Song B; Fong K-W; Cao Q; Licht JD; Zhao JC; Yu J
  • TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.
    Nat Commun Volume: 9 Page(s): 5007
    11/27/2018 Authors: Fong K-W; Zhao JC; Song B; Zheng B; Yu J
  • Ligand-independent CXCR7 activation of MAPK signaling leads to prostate cancer enzalutamide resistance
    Volume: 78
    07/01/2018 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Yu J
  • A novel role for polycomb group protein BMI1 in prostate cancer
    Volume: 78
    07/01/2018 Authors: Zhu S; Zhang D; Yan L; Jiang W; Liu Q; Wang R; Xia B; Zhao JC; Wang R-F; Shi X
  • PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin 2 expression.
    EMBO Rep Volume: 19
    06/01/2018 Authors: Liu H; Dai X; Cao X; Yan H; Ji X; Zhang H; Shen S; Si Y; Zhang H; Chen J
  • BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.
    Nat Commun Volume: 9 Page(s): 500
    02/05/2018 Authors: Zhu S; Zhao D; Yan L; Jiang W; Kim J-S; Gu B; Liu Q; Wang R; Xia B; Zhao JC
  • Organoids model distinct Vitamin E effects at different stages of prostate cancer evolution.
    Sci Rep Volume: 7 Page(s): 16285
    11/24/2017 Authors: Njoroge RN; Unno K; Zhao JC; Naseem AF; Anker JF; McGee WA; Nonn L; Abdulkadir SA
  • Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism.
    Elife Volume: 6
    10/24/2017 Authors: Putzbach W; Gao QQ; Patel M; van Dongen S; Haluck-Kangas A; Sarshad AA; Bartom ET; Kim K-YA; Scholtens DM; Hafner M
  • FOXA1 inhibits prostate cancer neuroendocrine differentiation.
    Oncogene Volume: 36 Page(s): 4072 - 4080
    07/13/2017 Authors: Kim J; Jin H; Zhao JC; Yang YA; Li Y; Yang X; Dong X; Yu J
  • The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.
    Blood Cancer J Volume: 7 Page(s): e572
    06/16/2017 Authors: Zingariello M; Sancillo L; Martelli F; Ciaffoni F; Marra M; Varricchio L; Rana RA; Zhao C; Crispino JD; Migliaccio AR
  • Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.
    J Clin Invest Volume: 127 Page(s): 1316 - 1320
    04/03/2017 Authors: Gilles L; Arslan AD; Marinaccio C; Wen QJ; Arya P; McNulty M; Yang Q; Zhao JC; Konstantinoff K; Lasho T
  • CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.
    Cell Rep Volume: 18 Page(s): 2373 - 2386
    03/07/2017 Authors: Qadir AS; Ceppi P; Brockway S; Law C; Mu L; Khodarev NN; Kim J; Zhao JC; Putzbach W; Murmann AE
  • Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer.
    Cancer Res Volume: 77 Page(s): 412 - 422
    01/15/2017 Authors: Fong K-W; Zhao JC; Kim J; Li S; Yang YA; Song B; Rittie L; Hu M; Yang X; Perbal B
  • FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
    Nucleic Acids Res Volume: 44 Page(s): 8153 - 8164
    09/30/2016 Authors: Yang YA; Zhao JC; Fong K-W; Kim J; Li S; Song C; Song B; Zheng B; He C; Yu J
  • FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
    Oncogene Volume: 35 Page(s): 4335 - 4344
    08/18/2016 Authors: Zhao JC; Fong K-W; Jin H-J; Yang YA; Kim J; Yu J
  • The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.
    BMC Genomics Volume: 17 Page(s): 335
    05/04/2016 Authors: Zhao J; Li X; Guo M; Yu J; Yan C
  • LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.
    Oncogene Volume: 35 Page(s): 2746 - 2755
    05/01/2016 Authors: Xue X; Yang YA; Zhang A; Fong K-W; Kim J; Song B; Li S; Zhao JC; Yu J
  • LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.
    Cell Rep Volume: 13 Page(s): 209 - 221
    10/06/2015 Authors: Zhang A; Zhao JC; Kim J; Fong K-W; Yang YA; Chakravarti D; Mo Y-Y; Yu J
  • A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.
    Cell Res Volume: 25 Page(s): 997 - 1012
    09/01/2015 Authors: Shen S; Guo X; Yan H; Lu Y; Ji X; Li L; Liang T; Zhou D; Feng X-H; Zhao JC
  • TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.
    Oncogene Volume: 33 Page(s): 5183 - 5192
    10/30/2014 Authors: Kim J; Wu L; Zhao JC; Jin H-J; Yu J
  • Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.
    Nat Commun Volume: 5 Page(s): 3972
    05/30/2014 Authors: Jin H-J; Zhao JC; Wu L; Kim J; Yu J
  • ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer.
    Cancer Res Volume: 73 Page(s): 6068 - 6079
    10/01/2013 Authors: Wu L; Zhao JC; Kim J; Jin H-J; Wang C-Y; Yu J
  • Androgen receptor-independent function of FoxA1 in prostate cancer metastasis.
    Cancer Res Volume: 73 Page(s): 3725 - 3736
    06/15/2013 Authors: Jin H-J; Zhao JC; Ogden I; Bergan RC; Yu J
  • BRCA1 is a negative modulator of the PRC2 complex.
    EMBO J Volume: 32 Page(s): 1584 - 1597
    05/29/2013 Authors: Wang L; Zeng X; Chen S; Ding L; Zhong J; Zhao JC; Wang L; Sarver A; Koller A; Zhi J
  • Cooperation between Polycomb and androgen receptor during oncogenic transformation.
    Genome Res Volume: 22 Page(s): 322 - 331
    02/01/2012 Authors: Zhao JC; Yu J; Runkle C; Wu L; Hu M; Wu D; Liu JS; Wang Q; Qin ZS; Yu J
  • LARALink: a web application for cytogenetic linkage analysis.
    Clin Genet Volume: 67 Page(s): 314 - 321
    04/01/2005 Authors: Fayz B; Moldenhauer JS; Wang D; Zhao C; Yao B; Liu D; Weinsheimer S; Gardner L; Johnson A; Womble DD
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