Changsheng Zhao
- Department of Human Genetics
Associate Professor
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1760 Haygood Dr NE, Suite E369A
Overview
Our research primarily utilizes bioinformatics approaches to analyze high-throughput genomic data, aiming to unravel the molecular mechanisms underlying prostate cancer. Over the years, we has garnered extensive experience in Cancer Genomics and Bioinformatics, particularly in analyzing various data types such as Microarray, ChIP-seq, RNA-seq, ATAC-seq, scRNA-seq, scATAT-seq, Hi-C, Spatial Transcriptomics, MeDIP-Seq, BS-Seq, and Nanopore Long-read sequencing.
We have developed numerous computational pipelines for the routine processing of NGS data and are proactive in integrating newly published genomic data and acquiring advanced bioinformatics skills/tools. We are extending our research to other types of urological cancers, such as kidney and bladder cancers. Additionally, Our collaborative skills are well-demonstrated through multiple co-investigator grants and a wealth of co-authored publications.
Academic Appointment
- Associate Professor, Human Genetics, Emory University School of Medicine
Education
Degrees
- MD from Peking University
- MA Math, Computer Science from Eastern Michigan University
Research
Publications
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Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma.
Cancer Biol Ther Volume: 25 Page(s): 2364433
12/31/2024 Authors: Naranjo NM; Kennedy A; Testa A; Verrillo CE; Altieri AD; Kean R; Hooper DC; Yu J; Zhao J; Abinader O -
Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.
J Clin Invest Volume: 133
08/01/2023 Authors: Gritsina G; Fong K-W; Lu X; Lin Z; Xie W; Agarwal S; Lin D; Schiltz GE; Beltran H; Corey E -
Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
Oncogene Volume: 42 Page(s): 2126 - 2138
06/01/2023 Authors: Lin Z; Agarwal S; Tan S; Shi H; Lu X; Tao Z; Dong X; Wu X; Zhao JC; Yu J -
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
Mol Cell Volume: 82 Page(s): 4611 - 4626.e7
12/15/2022 Authors: Fong K-W; Zhao JC; Lu X; Kim J; Piunti A; Shilatifard A; Yu J -
FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A.
Oncogene Volume: 41 Page(s): 4259 - 4270
09/01/2022 Authors: Wang X; Brea L; Lu X; Gritsina G; Park SH; Xie W; Zhao JC; Yu J -
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.
Nat Genet Volume: 54 Page(s): 670 - 683
05/01/2022 Authors: Lu X; Fong K-W; Gritsina G; Wang F; Baca SC; Brea LT; Berchuck JE; Spisak S; Ross J; Morrissey C -
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
Sci Adv Volume: 7
04/01/2021 Authors: Park SH; Fong K-W; Kim J; Wang F; Lu X; Lee Y; Brea LT; Wadosky K; Guo C; Abdulkadir SA -
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.
Nat Commun Volume: 11 Page(s): 4153
08/19/2020 Authors: Vatapalli R; Sagar V; Rodriguez Y; Zhao JC; Unno K; Pamarthy S; Lysy B; Anker J; Han H; Yoo YA -
Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
Cancer Res Volume: 80 Page(s): 2072
05/15/2020 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Sharp A; Yuan W; Aversa C; Yang XJ -
Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.
Cell Res Volume: 29 Page(s): 773 - 775
09/01/2019 Authors: Xu B; Song B; Lu X; Kim J; Hu M; Zhao JC; Yu J