Chia-shi Wang

SOM: Peds: Nephrology
Associate Professor

chia-shi.wang@emory.edu

Overview

Dr. Wang is currently an Assistant Professor of Pediatrics in the Division of Pediatric Nephrology. She completed her residency training at Wake Forest University School of Medicine and her pediatric nephrology fellowship at Emory University School of Medicine. She has formal clinical research training with a Masters of Science in Clinical Research degree from Emory University. Her research focus is childhood nephrotic syndrome disease epidemiology, outcomes, and treatment. She has received career development funding (K23) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to test a novel mobile app for nephrotic syndrome management that she developed with engineers from the Georgia Tech Research Institute (UrApp). She has led and successfully completed a multicenter clinical drug trial (ATLANTIS, NCT02132195) and is an active site investigator of two large National Institute of Health sponsored clinical research networks - Cure Glomerulonephropathy (CureGN) and Nephrotic Syndrome Study Network (NEPTUNE). Within the Division of Pediatric Nephrology, Dr. Wang directs the Journal Club curriculum to enhance the scientific basis for acquiring medical knowledge and mentors fellows in clinical research and quality improvement initiatives.

Academic Appointment

Assistant Professor, Division of Pediatric Nephrology, Emory University School of Medicine

Education

Degrees

MSc from Emory University
MD from Wake Forest University, Winston-Salem
BA from University of Chicago

Research

Focus

Clinical Research
My research has focused predominantly in childhood nephrotic syndrome. I have described nephrotic syndrome disease epidemiology, risk factors, and outcomes using our center's database as well as national disease registries / networks. I have examined the efficacy of novel drug therapies for the treatment of nephrotic syndrome, including designing and leading a multicenter clinical trial. To improve nephrotic syndrome management, I have examined the role of mobile health for disease monitoring and management. I have tested text messaging in nephrotic syndrome and have created a novel mobile app in conjunction with Georgia Tech Research Institute. My ongoing efforts are to more fully understand nephrotic syndrome disease burden and factors in poor outcomes and successfully disseminate and implement evidence-based interventions for nephrotic syndrome management.

Publications

New Index Demonstrates Association between Social Vulnerability, Environmental Burden, and Kidney Failure Risk among Individuals with Glomerular Disease.
Clin J Am Soc Nephrol
01/17/2025 Authors: Dass LW; Smith AR; Krissberg J; Wang C-S; Robinson BM; Gbadegesin RA; Dave G; Gibson KL
Pediatric contributions and lessons learned from the NEPTUNE cohort study.
Pediatr Nephrol Volume: 39 Page(s): 2555 - 2568
09/01/2024 Authors: Modi ZJ; Zhai Y; Yee J; Desmond H; Hao W; Sampson MG; Sethna CB; Wang C-S; Gipson DS; Trachtman H
Growth in children with nephrotic syndrome: a post hoc analysis of the NEPTUNE study.
Pediatr Nephrol Volume: 39 Page(s): 2691 - 2701
09/01/2024 Authors: Maniar A; Gipson DS; Brady T; Srivastava T; Selewski DT; Greenbaum LA; Dell KM; Kaskel F; Massengill S; Tran C
Longitudinal analysis of blood pressure and lipids in childhood nephrotic syndrome.
Pediatr Nephrol Volume: 39 Page(s): 2161 - 2170
07/01/2024 Authors: Carboni J; Thomas E; Gipson DS; Brady TM; Srivastava T; Selewski DT; Greenbaum LA; Wang C-S; Dell KM; Kaskel F
Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today.
Kidney Int Volume: 105 Page(s): 218 - 230
02/01/2024 Authors: Trachtman H; Desmond H; Williams AL; Mariani LH; Eddy S; Ju W; Barisoni L; Ascani HK; Uhlmann WR; Spino C
Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study.
Am J Kidney Dis Volume: 83 Page(s): 37 - 46
01/01/2024 Authors: Wang C-S; Glenn DA; Helmuth M; Smith AR; Bomback AS; Canetta PA; Coppock GM; Khalid M; Tuttle KR; Bou-Matar R
Design of a User-Centered Electronic Health Tool for Glomerular Disease Management.
Glomerular Dis Volume: 4 Page(s): 105 - 118
01/01/2024 Authors: Oliverio AL; Peagler A; Mitchell R; Martinez A; Denham M; Mariani LH; Cobb J; Oommen AA; Alter G; Anzai M
The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.
Pediatr Nephrol Volume: 38 Page(s): 3297 - 3308
10/01/2023 Authors: Hingorani S; Gibson KL; Xie Y; Wang Y; Eddy S; Hartman J; Sampson M; Cassol C; Thomas D; Gipson DS
Treatment of edema in childhood nephrotic syndrome
Volume: 38 Page(s): 2467 - 2467
07/01/2023 Authors: Sullivan M; Londeree J; Wang C-S
Improving Hepatitis B Screening Prior to Rituximab: A Quality Improvement Project.
Children (Basel) Volume: 10
06/30/2023 Authors: Villacis-Nunez DS; Orenstein E; Selvaggio P; Rouster-Stevens K; Wang C-S; Thakral A
Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network.
Am J Kidney Dis Volume: 81 Page(s): 695 - 706.e1
06/01/2023 Authors: Chen DP; Helmuth ME; Smith AR; Canetta PA; Ayoub I; Mucha K; Kallash M; Kopp JB; Gbadegesin R; Gillespie BW
Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease.
Am J Kidney Dis Volume: 81 Page(s): 318 - 328.e1
03/01/2023 Authors: Krissberg JR; O'Shaughnessy MM; Smith AR; Helmuth ME; Almaani S; Aviles DH; Brathwaite KE; Cai Y; Cattran D; Gbadegesin R
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome.
Pediatr Nephrol Volume: 38 Page(s): 877 - 919
03/01/2023 Authors: Trautmann A; Boyer O; Hodson E; Bagga A; Gipson DS; Samuel S; Wetzels J; Alhasan K; Banerjee S; Bhimma R
Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis.
Kidney Int Volume: 103 Page(s): 565 - 579
03/01/2023 Authors: Mariani LH; Eddy S; AlAkwaa FM; McCown PJ; Harder JL; Nair V; Eichinger F; Martini S; Ademola AD; Boima V
Vaccine Attitudes and COVID-19 Vaccine Intention Among Parents of Children With Kidney Disease or Primary Hypertension.
Am J Kidney Dis Volume: 81 Page(s): 25 - 35.e1
01/01/2023 Authors: Wang C-S; Doma R; Westbrook AL; Johnson J; Anderson EJ; Greenbaum LA; Rana SA; George RP; Garro R; Khanna-Farber A
Glomerular B7-1 staining: toward precision medicine for treatment of recurrent focal segmental glomerulosclerosis.
Pediatr Nephrol Volume: 38 Page(s): 13 - 15
01/01/2023 Authors: Wang C-S; Smoyer WE; Cara-Fuentes G
Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis.
JAMA Netw Open Volume: 5 Page(s): e2228701
08/01/2022 Authors: Gipson DS; Troost JP; Spino C; Attalla S; Tarnoff J; Massengill S; Lafayette R; Vega-Warner V; Adler S; Gipson P
Determinants of medication adherence in childhood nephrotic syndrome and associations of adherence with clinical outcomes.
Pediatr Nephrol Volume: 37 Page(s): 1585 - 1595
07/01/2022 Authors: Wang C-S; Troost JP; Wang Y; Greenbaum LA; Gibson K; Trachtman H; Srivastava T; Reidy K; Kaskel F; Sethna CB
A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis.
Kidney Int Volume: 102 Page(s): 136 - 148
07/01/2022 Authors: McNulty MT; Fermin D; Eichinger F; Jang D; Kretzler M; Burtt NP; Pollak MR; Flannick J; Weins A; Friedman DJ
Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis.
J Am Soc Nephrol Volume: 33 Page(s): 1411 - 1426
07/01/2022 Authors: Zee J; Liu Q; Smith AR; Hodgin JB; Rosenberg A; Gillespie BW; Holzman LB; Barisoni L; Mariani LH; Nephrotic Syndrome Study Network (NEPTUNE)
IMPROVING ALLOGRAFT SURVIVAL BY INFORMING DONOR SELECTION IN KIDNEY TRANSPLANT RECIPIENTS UNDER 5 YEARS OLD
Volume: 36 Page(s): 3344 - 3345
10/01/2021 Authors: Barayre FM; Greenbaum LA; Garro R; Wang C-S; Winterberg PD; Patzer R; Hogan J
APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.
Pediatr Nephrol Volume: 36 Page(s): 2747 - 2757
09/01/2021 Authors: Zee J; McNulty MT; Hodgin JB; Zhdanova O; Hingorani S; Jefferson JA; Gibson KL; Trachtman H; Fornoni A; Dell KM
Grip Strength in Adults and Children with Cystinosis.
Kidney Int Rep Volume: 6 Page(s): 389 - 395
02/01/2021 Authors: Iyob-Tessema H; Wang C-S; Kennedy S; Reyes L; Shin S; Greenbaum LA; Hogan J
Plasma exchange in ANCA-associated vasculitis: the pro position.
Nephrol Dial Transplant Volume: 36 Page(s): 227 - 231
01/25/2021 Authors: Kronbichler A; Shin JI; Wang C-S; Szpirt WM; Segelmark M; Tesar V
Development and evaluation of deep learning-based segmentation of histologic structures in the kidney cortex with multiple histologic stains.
Kidney Int Volume: 99 Page(s): 86 - 101
01/01/2021 Authors: Jayapandian CP; Chen Y; Janowczyk AR; Palmer MB; Cassol CA; Sekulic M; Hodgin JB; Zee J; Hewitt SM; O'Toole J
Association of Obesity with Cardiovascular Risk Factors and Kidney Disease Outcomes in Primary Proteinuric Glomerulopathies.
Nephron Volume: 145 Page(s): 245 - 255
01/01/2021 Authors: Shah PP; Brady TM; Meyers KEC; O'Shaughnessy MM; Gibson KL; Srivastava T; Zee J; Cattran D; Tuttle KR; Gadegbeku C
Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study.
Kidney Int Rep Volume: 5 Page(s): 1679 - 1689
10/01/2020 Authors: Murphy SL; Mahan JD; Troost JP; Srivastava T; Kogon AJ; Cai Y; Davis TK; Fernandez H; Fornoni A; Gbadegesin RA
The longitudinal relationship between patient-reported outcomes and clinical characteristics among patients with focal segmental glomerulosclerosis in the Nephrotic Syndrome Study Network.
Clin Kidney J Volume: 13 Page(s): 597 - 606
08/01/2020 Authors: Troost JP; Waldo A; Carlozzi NE; Murphy S; Modersitzki F; Trachtman H; Nachman PH; Reidy KJ; Selewski DT; Herreshoff EG
eHealth in kidney care.
Nat Rev Nephrol Volume: 16 Page(s): 368 - 370
07/01/2020 Authors: Wang C-S; Ku E
A dual efficacy-implementation trial of a novel mobile application for childhood nephrotic syndrome management: the UrApp for childhood nephrotic syndrome management pilot study protocol (UrApp pilot study).
BMC Nephrol Volume: 21 Page(s): 125
04/09/2020 Authors: Wang C-S; Escoffery C; Patzer RE; McCracken C; Ross D; Rheault MN; Al-Uzri A; Greenbaum LA
Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome.
Kidney Int Rep Volume: 5 Page(s): 414 - 425
04/01/2020 Authors: Gipson DS; Trachtman H; Waldo A; Gibson KL; Eddy S; Dell KM; Srivastava T; Lemley KV; Greenbaum LA; Hingorani S
Treatment Patterns Among Adults and Children With Membranous Nephropathy in the Cure Glomerulonephropathy Network (CureGN).
Kidney Int Rep Volume: 4 Page(s): 1725 - 1734
12/01/2019 Authors: O'Shaughnessy MM; Troost JP; Bomback AS; Hladunewich MA; Ashoor IF; Gibson KL; Matar RB; Selewski DT; Srivastava T; Rheault MN
Renal allograft loss due to renal vascular thrombosis in the US pediatric renal transplantation.
Pediatr Nephrol Volume: 34 Page(s): 1545 - 1555
09/01/2019 Authors: Wang C-S; Greenbaum LA; Patzer RE; Garro R; Warshaw B; George RP; Winterberg PD; Patel K; Hogan J
Text Messaging for Disease Monitoring inChildhood Nephrotic Syndrome.
Kidney Int Rep Volume: 4 Page(s): 1066 - 1074
08/01/2019 Authors: Wang C-S; Troost JP; Greenbaum LA; Srivastava T; Reidy K; Gibson K; Trachtman H; Piette JD; Sethna CB; Meyers K
Development of a novel mobile application to detect urine protein for nephrotic syndrome disease monitoring.
BMC Med Inform Decis Mak Volume: 19 Page(s): 105
05/30/2019 Authors: Wang C-S; Boyd R; Mitchell R; Wright WD; McCracken C; Escoffery C; Patzer RE; Greenbaum LA
Health-related quality of life in glomerular disease.
Kidney Int Volume: 95 Page(s): 1209 - 1224
05/01/2019 Authors: Canetta PA; Troost JP; Mahoney S; Kogon AJ; Carlozzi N; Bartosh SM; Cai Y; Davis TK; Fernandez H; Fornoni A
Nephrotic Syndrome.
Pediatr Clin North Am Volume: 66 Page(s): 73 - 85
02/01/2019 Authors: Wang C-S; Greenbaum LA
Plasma Zonulin Levels in Childhood Nephrotic Syndrome.
Front Pediatr Volume: 7 Page(s): 197
01/01/2019 Authors: Trachtman H; Gipson DS; Lemley KV; Troost JP; Faul C; Morrison DJ; Vento SM; Ahn D-H; Goldberg JD
Adrenocorticotropic Hormone for Childhood Nephrotic Syndrome: The ATLANTIS Randomized Trial.
Clin J Am Soc Nephrol Volume: 13 Page(s): 1859 - 1865
12/07/2018 Authors: Wang C-S; Travers C; McCracken C; Leong T; Gbadegesin R; Quiroga A; Benfield MR; Hidalgo G; Srivastava T; Lo M
An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome.
Am J Hum Genet Volume: 103 Page(s): 232 - 244
08/02/2018 Authors: Gillies CE; Putler R; Menon R; Otto E; Yasutake K; Nair V; Hoover P; Lieb D; Li S; Eddy S
Mortality and Allograft Loss Trends Among US Pediatric Kidney Transplant Recipients With and Without Focal Segmental Glomerulosclerosis.
Am J Kidney Dis Volume: 71 Page(s): 392 - 398
03/01/2018 Authors: Wang C-S; Gander J; Patzer RE; Greenbaum LA
Ofatumumab for the treatment of childhood nephrotic syndrome.
Pediatr Nephrol Volume: 32 Page(s): 835 - 841
05/01/2017 Authors: Wang C-S; Liverman RS; Garro R; George RP; Glumova A; Karp A; Jernigan S; Warshaw B
RECURRENT FOCAL SEGMENTAL GLOMERULOSCLEROSIS AFTER PEDIATRIC RENAL TRANSPLANTATION SUCCESSFULLY TREATED WITH OFATUMUMAB: A NOVEL DRUG WITH PROMISING RESULTS.
Volume: 21 Page(s): 62 - 62
05/01/2017 Authors: Garro R; Glumova A; Wang C-S; Jernigan S
Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis.
Int J Nephrol Volume: 2017 Page(s): 2029583
01/01/2017 Authors: Wang C-S; Yan J; Palmer R; Bost J; Wolf MF; Greenbaum LA

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