Chinglai Yang PhD
- Administration
Affiliate Scientist
- (404) 712-9607
- chyang@emory.edu
-
Emory University School of Medicine
Microbiology and Immunology
CNR 5002
Overview
My research interests focus on vaccine development against three human viral pathogens: 1) the Ebola virus, which causes severe hemorrhagic fever with a high fatality up to 90%; 2) the influenza virus, which poses a great threat by causing influenza pandemics through antigenic shift and inter-species transmission; and 3) HIV, which is the etiologic agent of the AIDS pandemic. Specifically, our group has been pursuing the development and evaluation of novel DNA vaccines and virus-like particle (VLP) vaccines with the goal to improve their efficacy in eliciting protective immune responses against virus infection. Both DNA and VLP vaccines represent new platforms that are under development. They both offer several advantages over other vaccine strategies with respect to: 1) safety, as compared to attenuated viral vaccines; 2) antigenicity, compared to subunit vaccines; 3) utilization for repetitive boosting immunizations, as compared to recombinant viral vaccines; and 4) production cost, as compared to inactivated viral vaccines for viruses of high pathogenicity or low yield. Moreover, both DNA and VLP vaccines can be modified by molecular engineering to further enhance their immunogenicity for eliciting antibody and/or T cell responses. Over the years, we have accumulated extensive experience in the design and evaluation of viral DNA and VLP vaccines and gained substantial knowledge on their respective strength and weakness in eliciting desired immune responses pertaining to the specific need for protection against infection by different viruses.
Academic Appointment
- Assistant Professor, Department of Microbiology and Immunology, Emory University School of Medicine
Education
Degrees
- PhD from University of Alabama at Birmingham
- BS from University of Science and Technology of China
Research
Publications
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Author Correction: Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.
Sci Rep Volume: 13 Page(s): 13705
08/22/2023 Authors: Liu Y; Ye L; Lin F; Gomaa Y; Flyer D; Carrion R; Patterson JL; Prausnitz MR; Smith G; Glenn G -
Corrigendum to "Newcastle disease virus vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs" [Virology 432 (2012) 327-335].
Virology Volume: 573 Page(s): 176 - 177
08/01/2022 Authors: Kong D; Wen Z; Su H; Ge J; Chen W; Wang X; Wu C; Yang C; Chen H; Bu Z -
An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.
Proc Natl Acad Sci U S A Volume: 118
11/09/2021 Authors: Xia D; Jin R; Byagathvalli G; Yu H; Ye L; Lu C-Y; Bhamla MS; Yang C; Prausnitz MR -
Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection.
Front Microbiol Volume: 11 Page(s): 304
01/01/2020 Authors: Liu Y; Wen Z; Carrion R; Nunneley J; Staples H; Ticer A; Patterson JL; Compans RW; Ye L; Yang C -
Intradermal Vaccination With Adjuvanted Ebola Virus Soluble Glycoprotein Subunit Vaccine by Microneedle Patches Protects Mice Against Lethal Ebola Virus Challenge.
J Infect Dis Volume: 218 Page(s): S545 - S552
11/22/2018 Authors: Liu Y; Ye L; Lin F; Gomaa Y; Flyer D; Carrion R; Patterson JL; Prausnitz MR; Smith G; Glenn G -
Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.
Sci Rep Volume: 8 Page(s): 11193
07/25/2018 Authors: Liu Y; Ye L; Lin F; Gomaa Y; Flyer D; Carrion R; Patterson JL; Prausnitz MR; Smith G; Glenn G -
Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice.
Microbes Infect Volume: 19 Page(s): 626 - 634
12/01/2017 Authors: Wen Z; Wang X; Dong K; Zhang H; Bu Z; Ye L; Yang C -
Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/PGA Nanoparticles Administered Using a Microneedle Patch.
Adv Healthc Mater Volume: 6
01/01/2017 Authors: Yang H-W; Ye L; Guo XD; Yang C; Compans RW; Prausnitz MR -
An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene.
Emerg Microbes Infect Volume: 5 Page(s): e65
06/22/2016 Authors: Sun Z; Zhu Y; Wang Q; Ye L; Dai Y; Su S; Yu F; Ying T; Yang C; Jiang S -
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Sci Rep Volume: 6 Page(s): 24897
04/25/2016 Authors: Dye JM; Wu H; Hooper JW; Khurana S; Kuehne AI; Coyle EM; Ortiz RA; Fuentes S; Herbert AS; Golding H