Claire-Anne Gutekunst PhD

Department of Neurosurgery
Associate Professor

(404) 727-1812
cguteku@emory.edu

Emory University
Neurosurgery
101 Woodruff Circle

Academic Appointment

Associate Professor, Neurosurgery, Emory University, Atlanta

Education

Degrees

Maitrise Psychophysiologie from University of Paris-Sud, Orsay
License Physiology from University of Paris-Sud, Orsay
DEUG (Diplôme d'Etudes Universitaires Générales) from University of Paris-Sud, Orsay
BA from Académie de Versailles
PhD from Emory University, Atlanta
MA from Emory University, Atlanta

Research

Focus

Neuropathology and neurobiology of Huntington's Disease. Molecular neuropathology of neurodegenerative disorders. The role of Hap1 and molecular composition and function of Stigmoid Bodies

Publications

Effects of temporal lobe seizures on visual recognition memory in a non-human primate model.
Epilepsy Behav Volume: 168 Page(s): 110428
07/01/2025 Authors: Sproule E; Connolly MJ; Dhillon A; Gutekunst C-A; Gross RE; Devergnas A
Adaptive wheel exercise for mouse models of Parkinson's Disease.
J Neurosci Methods Volume: 414 Page(s): 110314
02/01/2025 Authors: Skelton H; Grogan D; Kotlure A; Berglund K; Gutekunst C-A; Gross R
Non-invasive Temporal Interference Stimulation of the Hippocampus Suppresses Epileptic Biomarkers in Patients with Epilepsy: Biophysical Differences between Kilohertz and Amplitude Modulated Stimulation.
medRxiv
01/14/2025 Authors: Missey F; Acerbo E; Dickey A; Trajlinek J; Studnicka O; Lubrano C; De Araujo E Silva M; Brady E; Vsiansky V; Szabo JP
Organellular imaging in vivo reveals a depletion of endoplasmic reticular calcium during post-ictal cortical spreading depolarization.

09/24/2024 Authors: Stern MA; Cole ER; Gutekunst C-A; Yang JJ; Berglund K; Gross RE
Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization.
Res Sq
09/04/2024 Authors: Sendi MSE; Cole ER; Piallat B; Ellis CA; Eggers TE; Laxpati NG; Mahmoudi B; Gutekunst C-A; Devergnas A; Mayberg H
Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization.
bioRxiv
09/03/2024 Authors: Sendi MSE; Cole ER; Piallat B; Ellis CA; Eggers TE; Laxpati NG; Mahmoudi B; Gutekunst C-A; Devergnas A; Mayberg H
Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures.
Heliyon Volume: 10 Page(s): e34257
07/30/2024 Authors: Connolly MJ; Piallat B; Sendi M; Mahmoudi B; Higgins MK; Gutekunst C-A; Devergnas A; Gross RE
Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.
bioRxiv
04/25/2024 Authors: Connolly MJ; Jiang S; Samuel L; Gutekunst C-A; Gross RE; Devergnas A
Selective Posterior Cerebral Artery Wada Better Predicts Good Memory and Naming Outcomes Following Selective Stereotactic Thermal Ablation for Medial Temporal Lobe Epilepsy Than Internal Carotid Artery Wada.
medRxiv
03/26/2024 Authors: Drane DL; Acerbo E; Rogers A; Pedersen NP; Williamson A; Stern MA; Dickey AS; Howard BM; Bearden DJ; Okada N
An enhancer-AAV approach selectively targeting dentate granule cells of the mouse hippocampus.
Cell Rep Methods Volume: 4 Page(s): 100684
01/22/2024 Authors: Banks E; Gutekunst C-A; Vargish GA; Eaton A; Pelkey KA; McBain CJ; Zheng JQ; Olh VJ; Rowan MJM
Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.
PLoS One Volume: 19 Page(s): e0307906
01/01/2024 Authors: Connolly MJ; Jiang S; Samuel LC; Gutekunst C-A; Gross RE; Devergnas A
A novel enhancer-AAV approach selectively targeting dentate granule cells.
bioRxiv
05/11/2023 Authors: Banks E; Gutekunst C-A; Vargish GA; Eaton A; Pelkey KA; McBain CJ; Zheng JQ; Olh VJ; Rowan MJ
The laterodorsal tegmentum and seizure regulation: Revisiting the evidence.
J Neurosci Res Volume: 101 Page(s): 256 - 262
02/01/2023 Authors: Grogan DP; Skelton HM; Fernandez AM; Gutekunst C-ANE; Gross RE
Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus.
NPJ Parkinsons Dis Volume: 9 Page(s): 9
01/25/2023 Authors: Davin A; Chabards S; Devergnas A; Benstaali C; Gutekunst C-AN; David O; Torres-Martinez N; Piallat B
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy.
Epilepsia Volume: 63 Page(s): 2192 - 2213
09/01/2022 Authors: Cole ER; Grogan DP; Laxpati NG; Fernandez AM; Skelton HM; Isbaine F; Gutekunst C-A; Gross RE
Loss of efferent projections of the hippocampal formation in the mouse intrahippocampal kainic acid model.
Epilepsy Res Volume: 180 Page(s): 106863
02/01/2022 Authors: Fernandez AM; Gutekunst C-A; Grogan DP; Pedersen NP; Gross RE
Applications of Bioluminescence-Optogenetics in Rodent Models.
Methods Mol Biol Volume: 2525 Page(s): 347 - 363
01/01/2022 Authors: Stern MA; Skelton H; Fernandez AM; Gutekunst C-AN; Gross RE; Berglund K
Kinetic monitoring of neuronal stress response to proteostasis dysfunction.
Mol Cell Neurosci Volume: 118 Page(s): 103682
01/01/2022 Authors: Santiago-Lopez AJ; Berglund K; Gross RE; Gutekunst C-AN
Bioluminescence-Optogenetics: A Practical Guide.
Methods Mol Biol Volume: 2525 Page(s): 333 - 346
01/01/2022 Authors: Stern MA; Skelton H; Fernandez AM; Gutekunst C-AN; Berglund K; Gross RE
Challenges in Implementing Relevant Exercise Interventions in Mouse Models of Parkinson's Disease
Volume: 36 Page(s): S277 - S278
09/01/2021 Authors: Grogan D; Skelton H; Rubiano J; Gutekunst C; Gross R
Quantifying Tremor in the R6/2 Mouse model of Huntington's Disease
Volume: 36 Page(s): S109 - S109
09/01/2021 Authors: Skelton H; Grogan D; Rubiano J; Gross R; Gutekunst C
A framework for designing data-driven optimization systems for neural modulation.
J Neural Eng Volume: 18
02/23/2021 Authors: Connolly MJ; Park S-E; Laxpati NG; Zaidi SA; Ghetiya M; Fernandez AM; Gutekunst C-A; Gross RE
In Vivo Assessment of Cell Death and Nigrostriatal Pathway Integrity Following Continuous Expression of C3 Transferase.
Neuroscience Volume: 442 Page(s): 183 - 192
08/21/2020 Authors: Gupta RV; Santiago-Lopez AJ; Berglund K; Gross RE; Gutekunst C-AN
Optimizing neuromodulation based on surrogate neural states for seizure suppression in a rat temporal lobe epilepsy model.
J Neural Eng Volume: 17 Page(s): 046009
07/16/2020 Authors: Park S-E; Connolly MJ; Exarchos I; Fernandez A; Ghetiya M; Gutekunst C-A; Gross RE
Step-function luminopsins for bimodal prolonged neuromodulation.
J Neurosci Res Volume: 98 Page(s): 422 - 436
03/01/2020 Authors: Berglund K; Fernandez AM; Gutekunst C-AN; Hochgeschwender U; Gross RE
NK cells clear -synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of -synucleinopathy.
Proc Natl Acad Sci U S A Volume: 117 Page(s): 1762 - 1771
01/21/2020 Authors: Earls RH; Menees KB; Chung J; Gutekunst C-A; Lee HJ; Hazim MG; Rada B; Wood LB; Lee J-K
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice.
J Neuroinflammation Volume: 16 Page(s): 250
12/03/2019 Authors: Earls RH; Menees KB; Chung J; Barber J; Gutekunst C-A; Hazim MG; Lee J-K
A Machine Learning Approach to Characterize the Modulation of the Hippocampal Rhythms Via Optogenetic Stimulation of the Medial Septum.
Int J Neural Syst Volume: 29 Page(s): 1950020
12/01/2019 Authors: Park S-E; Laxpati NG; Gutekunst C-A; Connolly MJ; Tung J; Berglund K; Mahmoudi B; Gross RE
C3 Transferase Gene Therapy for Continuous RhoA Inhibition.
Methods Mol Biol Volume: 1821 Page(s): 267 - 281
01/01/2018 Authors: Santiago-Lopez AJ; Gutekunst C-A; Gross RE
C3 Transferase Gene Therapy for Neuroprotection and Optic Nerve Regeneration
Volume: 58
06/01/2017 Authors: McDougal ME; Gutekunst C-A; Gross RE
C3 transferase gene therapy for continuous conditional RhoA inhibition.
Neuroscience Volume: 339 Page(s): 308 - 318
12/17/2016 Authors: Gutekunst C-A; Tung JK; McDougal ME; Gross RE
Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans.
J Neurosci Res Volume: 94 Page(s): 850 - 856
09/01/2016 Authors: Norflus F; Bu J; Guyton E; Gutekunst C-A
Bioluminescence imaging in live cells and animals.
Neurophotonics Volume: 3 Page(s): 025001
04/01/2016 Authors: Tung JK; Berglund K; Gutekunst C-A; Hochgeschwender U; Gross RE
Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates.
Neurosci Bull Volume: 31 Page(s): 705 - 713
12/01/2015 Authors: Singh A; Gutekunst CA; Uthayathas S; Finberg JPM; Mewes K; Gross RE; Papa SM; Feld Y
Gene Therapy for Neuroprotection and Axon Regeneration Using a RhoA-Inhibitory C3 Transferase Transgene Adeno-Associated Viral Vector in a Rodent Optic Nerve Crush Model
Volume: 93 Page(s): E523 - E524
11/01/2015 Authors: LaRiviere MJ; McDougal ME; Wang AW; Syrop SL; Robinson R; Lockhart A; Nguyen D; Gutekunst CA; Crocker IR; Gross RE
Inhibitory luminopsins: genetically-encoded bioluminescent opsins for versatile, scalable, and hardware-independent optogenetic inhibition.
Sci Rep Volume: 5 Page(s): 14366
09/24/2015 Authors: Tung JK; Gutekunst C-A; Gross RE
Plexin a4 expression in adult rat cranial nerves.
J Chem Neuroanat Volume: 61-62 Page(s): 13 - 19
11/01/2014 Authors: Gutekunst C-A; Gross RE
Fibroblast transplantion in the internal pallidum reduces L-Dopa-induced dyskinesias in MPTP treated non-human primates
Volume: 29 Page(s): S41 - S41
05/01/2014 Authors: Feld Y; Singh A; Gutekunst C-A; Uthayathas S; Gross RE; Papa SM
Deep brain stimulation macroelectrodes compared to multiple microelectrodes in rat hippocampus.
Front Neuroeng Volume: 7 Page(s): 16
01/01/2014 Authors: Arcot Desai S; Gutekunst C-A; Potter SM; Gross RE
Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter.
Front Neuroeng Volume: 7 Page(s): 40
01/01/2014 Authors: Laxpati NG; Mahmoudi B; Gutekunst C-A; Newman JP; Zeller-Townson R; Gross RE
Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells.
Int J Physiol Pathophysiol Pharmacol Volume: 5 Page(s): 11 - 20
01/01/2013 Authors: Gu H; Yu SP; Gutekunst C-A; Gross RE; Wei L
PlexinA4 distribution in the adult rat spinal cord and dorsal root ganglia.
J Chem Neuroanat Volume: 44 Page(s): 1 - 13
05/01/2012 Authors: Gutekunst C-A; Stewart EN; Franz CK; English AW; Gross RE
Exposure to Sodium 4-phenylbutyrate Does Not Increase Grp78 Levels in C. elegans following ER Stress Treatment.
Volume: 23
01/01/2012 Authors: Le GP; Gutekunst C-A; Gross RE; Norflus F
Construction of different clones of sC3 transferase prior to testing the effectiveness on growth of cells.
Volume: 23
01/01/2012 Authors: Norflus F; Gutekunst C-A; Gross RE
Analyzing neuronal activation with macroelectrode vs. microelectrode array stimulation.
Annu Int Conf IEEE Eng Med Biol Soc Volume: 2012 Page(s): 4144 - 4147
01/01/2012 Authors: Desai SA; Gutekunst C-A; Potter SM; Gross RE
Isolation and Purification of HAP1 Promoter, and Transformation into GFP Producing Plasmid
Volume: 22
01/01/2011 Authors: Mervin A; Dixon N; Gutekunst C-A; Norflus F
Spontaneous and evoked high-frequency oscillations in the tetanus toxin model of epilepsy.
Epilepsia Volume: 51 Page(s): 2289 - 2296
11/01/2010 Authors: Rolston JD; Laxpati NG; Gutekunst C-A; Potter SM; Gross RE
Expression by midbrain dopamine neurons of Sema3A and 3F receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype.
Mol Cell Neurosci Volume: 44 Page(s): 135 - 153
06/01/2010 Authors: Torre ER; Gutekunst C-A; Gross RE
Immunohistochemical Distribution of PlexinA4 in the Adult Rat Central Nervous System.
Front Neuroanat Volume: 4
01/01/2010 Authors: Gutekunst C-A; Stewart EN; Gross RE
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
J Neural Eng Volume: 6 Page(s): 056003
10/01/2009 Authors: McConnell GC; Rees HD; Levey AI; Gutekunst C-A; Gross RE; Bellamkonda RV
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
Neurobiol Dis Volume: 34 Page(s): 417 - 431
06/01/2009 Authors: Mastroberardino PG; Hoffman EK; Horowitz MP; Betarbet R; Taylor G; Cheng D; Na HM; Gutekunst C-A; Gearing M; Trojanowski JQ
A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.
J Mol Neurosci Volume: 37 Page(s): 37 - 49
01/01/2009 Authors: Mercer KB; Szlam SM; Manning E; Gernert KM; Walthall WW; Benian GM; Gutekunst C-A
The role of sema 3A and sema 3F as guidance cues during the development of the meso-telencephalic dopaminergic pathway
Volume: 17 Page(s): 467 - 468
01/01/2008 Authors: Gross RE; Torre E; Gutekunst C-A
Gene therapy for neural regeneration and transplantation: A lentiviral vector expressing C3 transferase increases axon outgrowth in vitro and in vivo
Volume: 85 Page(s): 46 - 47
01/01/2007 Authors: Gross RE; Mei Q; Gutekunst C-A; Torre E
The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies.
Cell Transplant Volume: 16 Page(s): 245 - 262
01/01/2007 Authors: Gross RE; Mei Q; Gutekunst C-A; Torre E
A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
Am J Hum Genet Volume: 78 Page(s): 947 - 960
06/01/2006 Authors: Procaccio V; Salazar G; Ono S; Styers ML; Gearing M; Davila A; Jimenez R; Juncos J; Gutekunst C-A; Meroni G
A lentiviral vector expressing c3 transferase increases axon outgrowth in vitro and in vivo: A gene therapy for neural regeneration and transplantation
Volume: 198 Page(s): 570 - 570
04/01/2006 Authors: Gross RE; Mei Q; Gutekunst CA; Torre E
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Neuron Volume: 44 Page(s): 977 - 986
12/16/2004 Authors: Huang K; Yanai A; Kang R; Arstikaitis P; Singaraja RR; Metzler M; Mullard A; Haigh B; Gauthier-Campbell C; Gutekunst C-A
Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice.
Neurobiol Dis Volume: 17 Page(s): 319 - 325
11/01/2004 Authors: Norflus F; Nanje A; Gutekunst C-A; Shi G; Cohen J; Bejarano M; Fox J; Ferrante RJ; Hersch SM
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Mol Cell Volume: 15 Page(s): 853 - 865
09/24/2004 Authors: Goehler H; Lalowski M; Stelzl U; Waelter S; Stroedicke M; Worm U; Droege A; Lindenberg KS; Knoblich M; Haenig C
Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice.
Exp Neurol Volume: 185 Page(s): 26 - 35
01/01/2004 Authors: Zala D; Bensadoun J-C; Pereira de Almeida L; Leavitt BR; Gutekunst C-A; Aebischer P; Hayden MR; Dglon N
Disruption of the endocytic protein HIP1 results in major neurological deficits and decreased AMPA receptor trafficking
Volume: 73 Page(s): 191 - 191
11/01/2003 Authors: Metzler MM; Gan L; Li B; Georgiou J; Gutekunst CA; Wang Y; Torre E; Wang YT; Roder JC; Raymond LA
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course.
J Immunol Volume: 171 Page(s): 4385 - 4391
10/15/2003 Authors: Tanzola MB; Robbie-Ryan M; Gutekunst CA; Brown MA
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Hum Mol Genet Volume: 12 Page(s): 1555 - 1567
07/01/2003 Authors: Slow EJ; van Raamsdonk J; Rogers D; Coleman SH; Graham RK; Deng Y; Oh R; Bissada N; Hossain SM; Yang Y-Z
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
EMBO J Volume: 22 Page(s): 3254 - 3266
07/01/2003 Authors: Metzler M; Li B; Gan L; Georgiou J; Gutekunst C-A; Wang Y; Torre E; Devon RS; Oh R; Legendre-Guillemin V
Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function.
J Histochem Cytochem Volume: 51 Page(s): 841 - 852
06/01/2003 Authors: Gutekunst C-A; Torre ER; Sheng Z; Yi H; Coleman SH; Riedel IB; Bujo H
A protocol for isolation and biochemical characterization of stigmoid bodies from rat brain.
J Neurosci Methods Volume: 125 Page(s): 27 - 32
05/30/2003 Authors: Torre ER; Coleman S; Yi H; Gutekunst CA
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Hum Mol Genet Volume: 11 Page(s): 2815 - 2828
11/01/2002 Authors: Singaraja RR; Hadano S; Metzler M; Givan S; Wellington CL; Warby S; Yanai A; Gutekunst C-A; Leavitt BR; Yi H
Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia.
Ann Neurol Volume: 52 Page(s): 465 - 476
10/01/2002 Authors: Gearing M; Juncos JL; Procaccio V; Gutekunst C-A; Marino-Rodriguez EM; Gyure KA; Ono S; Santoianni R; Krawiecki NS; Wallace DC
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
J Neurosci Volume: 22 Page(s): 7862 - 7872
09/15/2002 Authors: Wellington CL; Ellerby LM; Gutekunst C-A; Rogers D; Warby S; Graham RK; Loubser O; van Raamsdonk J; Singaraja R; Yang Y-Z
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
Nat Neurosci Volume: 5 Page(s): 731 - 736
08/01/2002 Authors: Panov AV; Gutekunst C-A; Leavitt BR; Hayden MR; Burke JR; Strittmatter WJ; Greenamyre JT
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.
Hum Mol Genet Volume: 11 Page(s): 945 - 959
04/15/2002 Authors: Chan EYW; Nasir J; Gutekunst C-A; Coleman S; Maclean A; Maas A; Metzler M; Gertsenstein M; Ross CA; Nagy A
Kinetics of reconstitution of mast cell-deficient mice
Volume: 16 Page(s): A1054 - A1054
03/22/2002 Authors: Tanzola MB; Robbie M; Gutekunst CA; Brown MA
Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.
Hum Mol Genet Volume: 11 Page(s): 633 - 640
03/15/2002 Authors: Wheeler VC; Gutekunst C-A; Vrbanac V; Lebel L-A; Schilling G; Hersch S; Friedlander RM; Gusella JF; Vonsattel J-P; Borchelt DR
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nat Cell Biol Volume: 4 Page(s): 95 - 105
02/01/2002 Authors: Gervais FG; Singaraja R; Xanthoudakis S; Gutekunst C-A; Leavitt BR; Metzler M; Hackam AS; Tam J; Vaillancourt JP; Houtzager V
HIP1(-/-) mice develop a adult onset phenotype characterized by thoracolumbar kyphosis, alterations in synaptic plasticity and a defect in reproduction
Volume: 12 Page(s): 395A - 395A
11/01/2001 Authors: Metzler MM; Georgiou J; Gutekunst CA; Oh R; Gan L; Rich M; Roder J; Hayden MR
Neurodegeneration and mild gait abnormalities in Huntington's disease knock-in mice.
Volume: 69 Page(s): 551 - 551
10/01/2001 Authors: Wheeler VC; Gutekunst CA; Vrbanac V; Lebel L; Vonsattel JP; Gusella JF; MacDonald ME
Stigmoid bodies in the developing and adult brain of mice and rats.
Volume: 15 Page(s): A130 - A130
03/07/2001 Authors: Gutekunst CANE; Saavedra C; Sheng ZJ; Torre ER
A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level.
J Histochem Cytochem Volume: 49 Page(s): 279 - 284
03/01/2001 Authors: Yi H; Leunissen J; Shi G; Gutekunst C; Hersch S
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
J Biol Chem Volume: 275 Page(s): 41299 - 41308
12/29/2000 Authors: Hackam AS; Yassa AS; Singaraja R; Metzler M; Gutekunst CA; Gan L; Warby S; Wellington CL; Vaillancourt J; Chen N
Accelerating the natural history of neurodegeneration in Huntington disease YAC transgenic mice: Facilitation of in vivo screening of potential therapeutic agents.
Volume: 67 Page(s): 427 - 427
10/01/2000 Authors: Leavitt BR; Gutekunst CA; Oh R; Chan E; Bissada N; Hersch S; Hayden MR
From molecular accomplices to pathways in the pathogenesis of HD: The roles of novel DED containing interacting proteins, HIP1 and Hippi.
Volume: 67 Page(s): 410 - 410
10/01/2000 Authors: Singaraja R; Gervais F; Hackam A; Xanthoudakis S; Houtzager V; Rasper D; Roy S; Leavitt B; Gutekunst CA; Hayden M
Recent advances in Huntington's disease.
Volume: 13 Page(s): 445 - 450
08/01/2000 Authors: Gutekunst CA; Norflus F; Hersch SM
Unusual neuropathology in an identical twin with juvenile-onset dystonia negative for the DYT1 GAG deletion.
Volume: 59 Page(s): 465 - 465
05/01/2000 Authors: Gearing M; Juncos JL; Gutekunst CA; Marino E; Wainer BH
Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis.
J Exp Med Volume: 191 Page(s): 813 - 822
03/06/2000 Authors: Secor VH; Secor WE; Gutekunst CA; Brown MA
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
Hum Mol Genet Volume: 9 Page(s): 503 - 513
03/01/2000 Authors: Wheeler VC; White JK; Gutekunst CA; Vrbanac V; Weaver M; Li XJ; Li SH; Yi H; Vonsattel JP; Gusella JF
Huntington aggregates may not predict neuronal death in Huntington's disease.
Ann Neurol Volume: 46 Page(s): 842 - 849
12/01/1999 Authors: Kuemmerle S; Gutekunst CA; Klein AM; Li XJ; Li SH; Beal MF; Hersch SM; Ferrante RJ
Endogenous huntingtin modulates the cellular toxicity of mutant huntingtin.
Volume: 65 Page(s): A457 - A457
10/01/1999 Authors: Leavitt BR; Hackam A; Gutekunst CA; McCutcheon K; Yassa A; Singaraja R; Kimel G; Hersch S; Vogl W; Hayden MR
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Philos Trans R Soc Lond B Biol Sci Volume: 354 Page(s): 1047 - 1055
06/29/1999 Authors: Hackam AS; Hodgson JG; Singaraja R; Zhang T; Gan L; Gutekunst CA; Hersch SM; Hayden MR
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Neuron Volume: 23 Page(s): 181 - 192
05/01/1999 Authors: Hodgson JG; Agopyan N; Gutekunst CA; Leavitt BR; LePiane F; Singaraja R; Smith DJ; Bissada N; McCutcheon K; Nasir J
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
J Neurosci Volume: 19 Page(s): 2522 - 2534
04/01/1999 Authors: Gutekunst CA; Li SH; Yi H; Mulroy JS; Kuemmerle S; Jones R; Rye D; Ferrante RJ; Hersch SM; Li XJ
Association of HAP1 isoforms with a unique cytoplasmic structure.
J Neurochem Volume: 71 Page(s): 2178 - 2185
11/01/1998 Authors: Li SH; Gutekunst CA; Hersch SM; Li XJ
The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.
J Neurosci Volume: 18 Page(s): 7674 - 7686
10/01/1998 Authors: Gutekunst CA; Li SH; Yi H; Ferrante RJ; Li XJ; Hersch SM
A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.
J Biol Chem Volume: 273 Page(s): 19220 - 19227
07/24/1998 Authors: Li SH; Hosseini SH; Gutekunst CA; Hersch SM; Ferrante RJ; Li XJ
Interaction of huntingtin-associated protein with dynactin P150Glued.
J Neurosci Volume: 18 Page(s): 1261 - 1269
02/15/1998 Authors: Li SH; Gutekunst CA; Hersch SM; Li XJ
Stigmoid bodies contain huntingtin associated protein (HAP-1)
Page(s): 759 - 760
01/01/1998 Authors: Yi H; Li SH; Li XX; Hersch SM; Gutekunst CA
N-terminal fragments of mutant huntingtin form filamentous aggregates in HD brain
Page(s): 843 - 844
01/01/1998 Authors: Yi H; Li SH; Li XJ; Hersch SM; Gutekunst CA
Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.
Cell Volume: 91 Page(s): 753 - 763
12/12/1997 Authors: Ordway JM; Tallaksen-Greene S; Gutekunst CA; Bernstein EM; Cearley JA; Wiener HW; Dure LS; Lindsey R; Hersch SM; Jope RS
Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.
J Neurosci Volume: 17 Page(s): 3052 - 3063
05/01/1997 Authors: Ferrante RJ; Gutekunst CA; Persichetti F; McNeil SM; Kowall NW; Gusella JF; MacDonald ME; Beal MF; Hersch SM
Neostriatal Huntingtin immunoreactivity correlates with vulnerability to neurodegeneration in Huntington's disease.
Volume: 56 Page(s): 68 - 68
05/01/1997 Authors: Hersch SM; Gutekunst CA; Ferrante RJ
Heterogeneous expression of huntingtin immunoreactivity in the normal human neostriatum
Volume: 48 Page(s): 22006 - 22006
03/01/1997 Authors: Ferrante RJ; Gutekunst CA; Persichetti F; Kowall NW; Gusella JF; Beal F; MacDonald ME; Hersch SM
Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes.
J Neurosci Volume: 17 Page(s): 1539 - 1547
03/01/1997 Authors: Feng Y; Gutekunst CA; Eberhart DE; Yi H; Warren ST; Hersch SM
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.
Proc Natl Acad Sci U S A Volume: 92 Page(s): 8710 - 8714
09/12/1995 Authors: Gutekunst CA; Levey AI; Heilman CJ; Whaley WL; Yi H; Nash NR; Rees HD; Madden JJ; Hersch SM
IDENTIFICATION OF THE HUNTINGTONS-DISEASE PROTEIN IN RAT, MONKEY, AND HUMAN USING ANTIFUSION PROTEIN ANTIBODIES
Volume: 38 Page(s): 298 - 298
08/01/1995 Authors: HERSCH SM; LEVEY AI; GUTEKUNST CA
Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents.
J Neurosci Volume: 15 Page(s): 5222 - 5237
07/01/1995 Authors: Hersch SM; Ciliax BJ; Gutekunst CA; Rees HD; Heilman CJ; Yung KK; Bolam JP; Ince E; Yi H; Levey AI
Preoptic and subthalamic connections with the caudal brainstem are important for copulation in the male rat.
Behav Neurosci Volume: 108 Page(s): 758 - 766
08/01/1994 Authors: Maillard-Gutekunst CA; Edwards DA
Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies.
J Neurosci Volume: 14 Page(s): 3351 - 3363
05/01/1994 Authors: Hersch SM; Gutekunst CA; Rees HD; Heilman CJ; Levey AI
Lack of strain differences in spatial learning among seizure-prone and seizure-resistant mice.
Behav Genet Volume: 23 Page(s): 385 - 389
07/01/1993 Authors: Gutekunst CA; Hartney A; Rees HD; Green RC
Excitotoxin lesions of the zona incerta/lateral tegmentum continuum: effects on male sexual behavior in rats.
Behav Brain Res Volume: 46 Page(s): 143 - 149
12/20/1991 Authors: Maillard CA; Edwards DA
Computer-assisted analysis of behavior-brain damage relationships.
Physiol Behav Volume: 48 Page(s): 189 - 193
07/01/1990 Authors: Edwards DA; Maillard CA
Subthalamic and mesencephalic locomotor regions: brain damage augments the importance of female movement for the display of sexual behavior in male rats.
Physiol Behav Volume: 44 Page(s): 803 - 809
01/01/1988 Authors: Edwards DA; Maillard CA
[Subthalamic lesions eliminate sexual behavior in the male rat].
J Physiol (Paris) Volume: 83 Page(s): 50 - 55
01/01/1988 Authors: Maillard CA; Edwards DA

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Claire-Anne Gutekunst PhD

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